MCID: CLV002
MIFTS: 27

Clivus Chordoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Clivus Chordoma

MalaCards integrated aliases for Clivus Chordoma:

Name: Clivus Chordoma 12 15
Chordoma of Clivus 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:6312
NCIt 49 C5412
UMLS 71 C1333071

Summaries for Clivus Chordoma

Disease Ontology : 12 A chordoma of skull base that is located in the clivus.

MalaCards based summary : Clivus Chordoma, also known as chordoma of clivus, is related to chordoma and tuberous sclerosis, and has symptoms including headache An important gene associated with Clivus Chordoma is COTL1 (Coactosin Like F-Actin Binding Protein 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and MET promotes cell motility. The drug Pharmaceutical Solutions has been mentioned in the context of this disorder. Affiliated tissues include bone, brain and cortex.

Related Diseases for Clivus Chordoma

Graphical network of the top 20 diseases related to Clivus Chordoma:



Diseases related to Clivus Chordoma

Symptoms & Phenotypes for Clivus Chordoma

UMLS symptoms related to Clivus Chordoma:


headache

Drugs & Therapeutics for Clivus Chordoma

Drugs for Clivus Chordoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sperimentazione Clinica Del Sistema INSIDE - Innovative SolutIons for DosimEtry in Hadrontherapy - Per il Monitoraggio Del Trattamento in Adroterapia Not yet recruiting NCT03662373

Search NIH Clinical Center for Clivus Chordoma

Genetic Tests for Clivus Chordoma

Anatomical Context for Clivus Chordoma

MalaCards organs/tissues related to Clivus Chordoma:

40
Bone, Brain, Cortex, Hypothalamus

Publications for Clivus Chordoma

Articles related to Clivus Chordoma:

(show top 50) (show all 78)
# Title Authors PMID Year
1
The Effect of Endoscopic Endonasal Transsphenoidal Skull Base Surgery on Cochlear Function. 61
31750046 2019
2
Clivus Intraosseous Meningioma Mimicking Chordoma. 61
31449204 2019
3
CLIVUS CHORDOMA. 61
32010364 2019
4
Radiation-Induced Moyamoya Syndrome After Proton Therapy in Child with Clival Chordoma: Natural History and Surgical Treatment. 61
30583132 2019
5
The High Cervical Anterolateral Retropharyngeal Approach. 61
30610315 2019
6
Identification of therapeutic targets in chordoma through comprehensive genomic and transcriptomic analyses. 61
30322893 2018
7
A Staged Strategy for Craniocervical Junction Chordoma with Combination of Endoscopic Endonasal Approach and Far Lateral Approach with Endoscopic Assistance: Case Report. 61
30210992 2018
8
Cranial Chordoma: A New Preoperative Grading System. 61
29126120 2018
9
Cardiac Metastasis from Clivus Chordoma. 61
29454123 2018
10
Maximum surgical resection and adjuvant intensity-modulated radiotherapy with simultaneous integrated boost for skull base chordoma. 61
27502775 2017
11
HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas. 61
28515451 2017
12
An unusual case of acquired pedophilic behavior following compression of orbitofrontal cortex and hypothalamus by a Clivus Chordoma. 61
27159984 2016
13
Tumour seeding in the surgical pathway after resection of skull base chordoma. 61
27330428 2016
14
Bone invasiveness is associated with prognosis in clivus chordomas. 61
26810468 2016
15
Establishment of clival chordoma cell line MUG-CC1 and lymphoblastoid cells as a model for potential new treatment strategies. 61
27072875 2016
16
Experimental study on differences in clivus chordoma bone invasion: an iTRAQ-based quantitative proteomic analysis. 61
25793716 2015
17
Sustained response of a clivus chordoma to erlotinib after imatinib failure. 61
25762924 2015
18
Benign and malignant diseases of the clivus. 61
25168701 2014
19
Augmented reality-assisted skull base surgery. 61
25245926 2014
20
A case of chordoma invading multiple neuroaxial bones: report of ten years follow up. 61
24101282 2013
21
[A case of clivus chordoma with first appearance of sudden deafness]. 61
23002653 2012
22
WE-G-BRCD-02: Speed Up Standard Optimization of IMPT Treatment Planning Through the Application of GPUs. 61
28519616 2012
23
On "clivus chordoma: is it enough to image the primary site?" (skull base 2010;20:111-113). 61
22470272 2011
24
The transnasal transclival approach for clivus chordoma. 61
21302187 2010
25
Clivus chordoma: is it enough to image the primary site? 61
20808536 2010
26
[Intracranial tumors in patients referred for optical coherence tomography examination as glaucoma suspects: case report]. 61
20027414 2009
27
Clivus metastases: report of seven patients and literature review. 61
19259614 2009
28
Clivus chordoma in continuity with a large pontine cyst. 61
19721775 2009
29
[Endoscopic endonasal surgery for extrasellar tumors: case presentation and its future perspective]. 61
19306643 2009
30
Fusions at the craniovertebral junction. 61
18389260 2008
31
Surgical approaches: postoperative care and complications "posterolateral-far lateral transcondylar approach to the ventral foramen magnum and upper cervical spinal canal". 61
18365213 2008
32
[Limitation of medical treatment and ethics in chronic recurrent Clivus chordoma]. 61
19165442 2008
33
[A preliminary study of endoscopic transoral trans-posteriorwall pharynx resection of hypo-clivus chordoma]. 61
17923047 2007
34
Infantile clivus chordoma without clivus involvement: case report and review of the literature. 61
16565853 2006
35
Recurrent and metastatic clivus chordoma: systemic palliative therapy retards disease progression. 61
16222158 2005
36
Clivus chordoma associated with a pontine arachnoid cyst. 61
15992705 2005
37
Visual complications of proton beam therapy for clival chordoma. 61
12724692 2003
38
Endoscopic endonasal transsphenoidal approach: outcome analysis of 100 consecutive procedures. 61
12494353 2002
39
Endoscopically assisted transoral-transpharyngeal approach to the craniovertebral junction. 61
12234431 2002
40
Candida albicans granuloma imitate clivus chordoma. 61
12111509 2002
41
Photophobia as the presenting visual symptom of chiasmal compression. 61
11937897 2002
42
Does the tuberous sclerosis complex include clivus chordoma? A case report. 61
11271387 2001
43
A tumor suppressor locus in familial and sporadic chordoma maps to 1p36. 61
10861454 2000
44
[Transoral microsurgical treatment of craniocervical malformation]. 61
11832004 2000
45
[Intradural clivus chordoma: surgical treatment with no tumor regrowth 12 years after surgery]. 61
10909291 2000
46
First cytogenetic study of a recurrent familial chordoma of the clivus. 61
10077147 1999
47
Possibilities and limitations of endoscopic management of nasal and paranasal sinus malignancies. 61
10635393 1999
48
Clinical results of the transoral operation for lesions of the craniovertebral junction and its abnormalities. 61
9952118 1999
49
Clivus chordoma. 61
9322379 1997
50
[Preservation of olfaction in frontal transbasal approach]. 61
9218255 1997

Variations for Clivus Chordoma

Expression for Clivus Chordoma

Search GEO for disease gene expression data for Clivus Chordoma.

Pathways for Clivus Chordoma

GO Terms for Clivus Chordoma

Cellular components related to Clivus Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.13 NID2 LAMB1 LAMA4
2 basement membrane GO:0005604 8.8 NID2 LAMB1 LAMA4

Biological processes related to Clivus Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anterior/posterior pattern specification GO:0009952 9.26 HOXA7 HOXA2
2 regulation of cell migration GO:0030334 9.16 NEXN LAMA4
3 embryonic skeletal system morphogenesis GO:0048704 8.96 HOXA7 HOXA2
4 extracellular matrix organization GO:0030198 8.8 NID2 LAMB1 LAMA4

Molecular functions related to Clivus Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 8.8 NID2 LAMB1 LAMA4

Sources for Clivus Chordoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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