MCID: CLV002
MIFTS: 36

Clivus Chordoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Clivus Chordoma

MalaCards integrated aliases for Clivus Chordoma:

Name: Clivus Chordoma 12 15
Chordoma of Clivus 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:6312
NCIt 51 C5412
UMLS 74 C1333071

Summaries for Clivus Chordoma

Disease Ontology : 12 A chordoma of skull base that is located in the clivus.

MalaCards based summary : Clivus Chordoma, also known as chordoma of clivus, is related to chordoma and tuberous sclerosis, and has symptoms including headache An important gene associated with Clivus Chordoma is HOXA10 (Homeobox A10), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. Affiliated tissues include bone, brain and cortex, and related phenotypes are hematopoietic system and endocrine/exocrine gland

Related Diseases for Clivus Chordoma

Diseases related to Clivus Chordoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 chordoma 10.8
2 tuberous sclerosis 10.2
3 spastic paraplegia 25, autosomal recessive 10.2 FGF13 FGF2
4 diffuse glomerulonephritis 10.2 FGF13 FGF2
5 gastric signet ring cell adenocarcinoma 10.2 FGF13 FGF2
6 dedifferentiated liposarcoma 10.1 CDK4 IGF1R
7 brachydactyly, type b2 10.1 FGF13 FGF2
8 brachydactyly, type b1 10.1 FGF13 FGF2
9 disuse amblyopia 10.1 FGF13 FGF2
10 cornea cancer 10.1 CDK4 FGF2
11 tuberous sclerosis 1 10.1
12 quadriplegia 10.1
13 herpes simplex 10.1
14 meningitis 10.1
15 arachnoid cysts 10.1
16 infiltrating lipoma 10.1 CDK4 FGF2
17 corneal neovascularization 10.1 CXCL12 FGF2
18 carbuncle 10.1 CDK4 FGF2
19 crouzon syndrome 10.0 FGF13 FGF2
20 limb ischemia 10.0 CXCL12 FGF2
21 muenke syndrome 10.0 FGF13 FGF2
22 connective tissue cancer 10.0 CDK4 FGF2
23 lipomatosis, multiple 10.0 CDK4 PTEN
24 skeletal muscle cancer 10.0 CDK4 IGF1R
25 myxoid liposarcoma 9.9 CDK4 IGF1R
26 acute t cell leukemia 9.9 CXCL12 PTEN
27 myeloma, multiple 9.9 CDK4 CXCL12 FGF2
28 endometrial adenocarcinoma 9.8 FGF2 HOXA10 PTEN
29 glioblastoma multiforme 9.8 CDK4 IGF1R PTEN
30 adamantinoma of long bones 9.7 CDK4 FGF2 PTEN
31 squamous cell carcinoma, head and neck 9.7 CDK4 FGF2 PTEN
32 brain cancer 9.7 CDK4 FGF2 PTEN
33 grade iii astrocytoma 9.7 CDK4 PTEN
34 glioma 9.6 CDK4 FGF2 PTEN
35 endometrial cancer 9.6 CDK4 HOXA10 IGF1R PTEN
36 large intestine cancer 9.6 CDK4 CXCL12 IGF1R PTEN
37 esophageal cancer 9.5 CDK4 FGF2 IGF1R PTEN
38 leukemia, acute myeloid 9.5 CXCL12 HOXA10 HOXA7 HOXA9

Graphical network of the top 20 diseases related to Clivus Chordoma:



Diseases related to Clivus Chordoma

Symptoms & Phenotypes for Clivus Chordoma

UMLS symptoms related to Clivus Chordoma:


headache

MGI Mouse Phenotypes related to Clivus Chordoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.87 CDK4 CXCL12 FGF2 HOXA7 HOXA9 IGF1R
2 endocrine/exocrine gland MP:0005379 9.85 CDK4 HOXA10 HOXA7 HOXA9 IGF1R PTEN
3 nervous system MP:0003631 9.7 CDK4 CXCL12 FGF13 FGF2 HOXA10 IGF1R
4 muscle MP:0005369 9.65 CDK4 CXCL12 FGF2 IGF1R PTEN
5 reproductive system MP:0005389 9.5 CDK4 CXCL12 FGF2 HOXA10 HOXA9 IGF1R
6 skeleton MP:0005390 9.1 FGF2 HOXA10 HOXA7 HOXA9 IGF1R PTEN

Drugs & Therapeutics for Clivus Chordoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 HSV1716 in Patients With Non-Central Nervous System (Non-CNS) Solid Tumors Completed NCT00931931 Phase 1

Search NIH Clinical Center for Clivus Chordoma

Genetic Tests for Clivus Chordoma

Anatomical Context for Clivus Chordoma

MalaCards organs/tissues related to Clivus Chordoma:

42
Bone, Brain, Cortex, Hypothalamus, Skeletal Muscle, T Cells, Myeloid

Publications for Clivus Chordoma

Articles related to Clivus Chordoma:

(show all 29)
# Title Authors Year
1
Cardiac Metastasis from Clivus Chordoma. ( 29454123 )
2018
2
An unusual case of acquired pedophilic behavior following compression of orbitofrontal cortex and hypothalamus by a Clivus Chordoma. ( 27159984 )
2016
3
Sustained response of a clivus chordoma to erlotinib after imatinib failure. ( 25762924 )
2015
4
Experimental study on differences in clivus chordoma bone invasion: an iTRAQ-based quantitative proteomic analysis. ( 25793716 )
2015
5
On "clivus chordoma: is it enough to image the primary site?" (skull base 2010;20:111-113). ( 22470272 )
2011
6
Clivus chordoma: is it enough to image the primary site? ( 20808536 )
2010
7
The transnasal transclival approach for clivus chordoma. ( 21302187 )
2010
8
Clivus chordoma in continuity with a large pontine cyst. ( 19721775 )
2009
9
[Limitation of medical treatment and ethics in chronic recurrent Clivus chordoma]. ( 19165442 )
2008
10
Infantile clivus chordoma without clivus involvement: case report and review of the literature. ( 16565853 )
2006
11
Clivus chordoma associated with a pontine arachnoid cyst. ( 15992705 )
2005
12
Recurrent and metastatic clivus chordoma: systemic palliative therapy retards disease progression. ( 16222158 )
2005
13
Candida albicans granuloma imitate clivus chordoma. ( 12111509 )
2002
14
Does the tuberous sclerosis complex include clivus chordoma? A case report. ( 11271387 )
2001
15
Herpes simplex meningitis after surgical removal of a clivus chordoma. ( 9177973 )
1997
16
Clivus chordoma. ( 9322379 )
1997
17
Proton radiation therapy for clivus chordoma--case report. ( 7683125 )
1993
18
Congenital clivus chordoma. ( 8517337 )
1993
19
Transoral transpalatal removal of a giant premesencephalic clivus chordoma. ( 1776517 )
1991
20
Clivus chordoma: a report of 12 recent cases and review of the literature. ( 17170837 )
1991
21
Surgical access for clivus chordoma. The University of California, San Francisco, experience. ( 2917064 )
1989
22
Clivus chordoma in a 9-year-old child: case report and review of the literature. ( 3152925 )
1987
23
Clivus chordoma in childhood. ( 3589943 )
1987
24
Clivus chordoma in a child with tuberous sclerosis: CT and MR demonstration. ( 3805419 )
1987
25
Bilateral abducens nerve palsies from clivus chordoma. ( 7258964 )
1981
26
Clivus chordoma with distinct vascularity demonstrated by angiography. ( 896037 )
1977
27
Clivus chordoma with unusual bone sclerosis and brainstem invasion. A case report with review of the radiology of cranial chordomas. ( 1212128 )
1975
28
Transcervical removal of a clivus chordoma in a 2-year-old child. Reversal of quadriplegia and bulbar paralysis. ( 5531855 )
1970
29
A transcervical transclival approach to the ventral surface of the brain stem for removal of a clivus chordoma. ( 5295919 )
1966

Variations for Clivus Chordoma

Expression for Clivus Chordoma

Search GEO for disease gene expression data for Clivus Chordoma.

Pathways for Clivus Chordoma

Pathways related to Clivus Chordoma according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 CDK4 CXCL12 FGF13 FGF2 IGF1R PTEN
2
Show member pathways
13.08 CXCL12 FGF13 FGF2 IGF1R PTEN
3
Show member pathways
12.98 CXCL12 FGF13 FGF2 IGF1R PTEN
4
Show member pathways
12.92 CXCL12 FGF13 FGF2 IGF1R PTEN
5
Show member pathways
12.77 CXCL12 FGF13 FGF2 IGF1R
6
Show member pathways
12.7 CDK4 FGF2 IGF1R PTEN
7
Show member pathways
12.69 CDK4 CXCL12 FGF2 PTEN
8
Show member pathways
12.45 CXCL12 FGF13 FGF2 IGF1R PTEN
9
Show member pathways
12.34 CDK4 FGF2 IGF1R PTEN
10
Show member pathways
12.3 CDK4 FGF2 IGF1R PTEN
11
Show member pathways
12.03 CXCL12 FGF13 FGF2 IGF1R
12 11.97 HOXA10 HOXA9 IGF1R
13
Show member pathways
11.94 CDK4 IGF1R PTEN
14 11.84 CDK4 IGF1R PTEN
15
Show member pathways
11.77 CXCL12 FGF13 FGF2 IGF1R
16 11.75 CDK4 CXCL12 FGF2 IGF1R PTEN
17 11.54 CDK4 IGF1R PTEN
18 11.27 CDK4 PTEN
19 11.26 FGF2 IGF1R
20 11.05 IGF1R PTEN
21 11.04 CXCL12 FGF2
22 10.95 CXCL12 FGF13 FGF2 IGF1R
23 10.68 CXCL12 FGF13 FGF2 IGF1R

GO Terms for Clivus Chordoma

Cellular components related to Clivus Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.8 CDK4 HOXA10 HOXA9

Biological processes related to Clivus Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.54 FGF2 HOXA7 PTEN
2 regulation of gene expression GO:0010468 9.5 CDK4 HOXA10 HOXA9
3 animal organ regeneration GO:0031100 9.43 CDK4 CXCL12
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.4 FGF2 PTEN
5 proximal/distal pattern formation GO:0009954 9.26 HOXA10 HOXA9
6 uterus development GO:0060065 9.16 HOXA10 HOXA9
7 anterior/posterior pattern specification GO:0009952 9.13 HOXA9 HOXA10 HOXA7
8 positive regulation of cell proliferation GO:0008284 9.02 CDK4 IGF1R FGF2 CXCL12 PTEN

Molecular functions related to Clivus Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.8 CXCL12 FGF13 FGF2

Sources for Clivus Chordoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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