MCID: CLV002
MIFTS: 33

Clivus Chordoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Clivus Chordoma

MalaCards integrated aliases for Clivus Chordoma:

Name: Clivus Chordoma 12 15
Chordoma of Clivus 12 72

Classifications:



External Ids:

Disease Ontology 12 DOID:6312
NCIt 50 C5412
UMLS 72 C1333071

Summaries for Clivus Chordoma

Disease Ontology : 12 A chordoma of skull base that is located in the clivus.

MalaCards based summary : Clivus Chordoma, also known as chordoma of clivus, is related to chordoma and tuberous sclerosis, and has symptoms including headache An important gene associated with Clivus Chordoma is HOXA10 (Homeobox A10), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. The drug Pharmaceutical Solutions has been mentioned in the context of this disorder. Affiliated tissues include bone, brain and cortex, and related phenotypes are hematopoietic system and endocrine/exocrine gland

Related Diseases for Clivus Chordoma

Diseases related to Clivus Chordoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 chordoma 10.9
2 tuberous sclerosis 10.3
3 spastic paraplegia 25, autosomal recessive 10.3 FGF2 FGF13
4 diffuse glomerulonephritis 10.3 FGF2 FGF13
5 gastric signet ring cell adenocarcinoma 10.3 FGF2 FGF13
6 dedifferentiated liposarcoma 10.2 IGF1R CDK4
7 chondroid chordoma 10.2
8 dysphagia 10.2
9 brachydactyly, type b2 10.2 FGF2 FGF13
10 disuse amblyopia 10.2 FGF2 FGF13
11 brachydactyly, type b1 10.2 FGF2 FGF13
12 cornea cancer 10.2 FGF2 CDK4
13 infiltrating lipoma 10.1 FGF2 CDK4
14 carbuncle 10.1 FGF2 CDK4
15 corneal neovascularization 10.1 FGF2 CXCL12
16 otitis media 10.1
17 tuberous sclerosis 1 10.1
18 branchiootic syndrome 1 10.1
19 meningioma, radiation-induced 10.1
20 meningioma, familial 10.1
21 hydrops, lactic acidosis, and sideroblastic anemia 10.1
22 hydrocephalus 10.1
23 spinal meningioma 10.1
24 locked-in syndrome 10.1
25 quadriplegia 10.1
26 cranial nerve palsy 10.1
27 secretory meningioma 10.1
28 lymphoplasmacyte-rich meningioma 10.1
29 clivus meningioma 10.1
30 herpes simplex 10.1
31 meningitis 10.1
32 pathologic nystagmus 10.1
33 arachnoid cysts 10.1
34 cerebrospinal fluid leak 10.1
35 congenital hydrocephalus 10.1
36 headache 10.1
37 rare tumor 10.1
38 rare surgical neurologic disease 10.1
39 crouzon syndrome 10.1 FGF2 FGF13
40 limb ischemia 10.1 FGF2 CXCL12
41 connective tissue cancer 10.0 FGF2 CDK4
42 muenke syndrome 10.0 FGF2 FGF13
43 lipomatosis, multiple 10.0 PTEN CDK4
44 skeletal muscle cancer 9.9 IGF1R CDK4
45 acute t cell leukemia 9.9 PTEN CXCL12
46 myxoid liposarcoma 9.8 IGF1R CDK4
47 myeloma, multiple 9.8 FGF2 CXCL12 CDK4
48 endometrial adenocarcinoma 9.7 PTEN HOXA10 FGF2
49 glioblastoma multiforme 9.6 PTEN IGF1R CDK4
50 adamantinoma of long bones 9.6 PTEN FGF2 CDK4

Graphical network of the top 20 diseases related to Clivus Chordoma:



Diseases related to Clivus Chordoma

Symptoms & Phenotypes for Clivus Chordoma

UMLS symptoms related to Clivus Chordoma:


headache

MGI Mouse Phenotypes related to Clivus Chordoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.87 CDK4 CXCL12 FGF2 HOXA7 HOXA9 IGF1R
2 endocrine/exocrine gland MP:0005379 9.85 CDK4 HOXA10 HOXA7 HOXA9 IGF1R PTEN
3 nervous system MP:0003631 9.7 CDK4 CXCL12 FGF13 FGF2 HOXA10 IGF1R
4 muscle MP:0005369 9.65 CDK4 CXCL12 FGF2 IGF1R PTEN
5 reproductive system MP:0005389 9.5 CDK4 CXCL12 FGF2 HOXA10 HOXA9 IGF1R
6 skeleton MP:0005390 9.1 FGF2 HOXA10 HOXA7 HOXA9 IGF1R PTEN

Drugs & Therapeutics for Clivus Chordoma

Drugs for Clivus Chordoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sperimentazione Clinica Del Sistema INSIDE - Innovative SolutIons for DosimEtry in Hadrontherapy - Per il Monitoraggio Del Trattamento in Adroterapia Not yet recruiting NCT03662373

Search NIH Clinical Center for Clivus Chordoma

Genetic Tests for Clivus Chordoma

Anatomical Context for Clivus Chordoma

MalaCards organs/tissues related to Clivus Chordoma:

41
Bone, Brain, Cortex, Hypothalamus

Publications for Clivus Chordoma

Articles related to Clivus Chordoma:

(show top 50) (show all 75)
# Title Authors PMID Year
1
Radiation-Induced Moyamoya Syndrome After Proton Therapy in Child with Clival Chordoma: Natural History and Surgical Treatment. 38
30583132 2019
2
The High Cervical Anterolateral Retropharyngeal Approach. 38
30610315 2019
3
Identification of therapeutic targets in chordoma through comprehensive genomic and transcriptomic analyses. 38
30322893 2018
4
A Staged Strategy for Craniocervical Junction Chordoma with Combination of Endoscopic Endonasal Approach and Far Lateral Approach with Endoscopic Assistance: Case Report. 38
30210992 2018
5
Cranial Chordoma: A New Preoperative Grading System. 38
29126120 2018
6
Cardiac Metastasis from Clivus Chordoma. 38
29454123 2018
7
Maximum surgical resection and adjuvant intensity-modulated radiotherapy with simultaneous integrated boost for skull base chordoma. 38
27502775 2017
8
HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas. 38
28515451 2017
9
An unusual case of acquired pedophilic behavior following compression of orbitofrontal cortex and hypothalamus by a Clivus Chordoma. 38
27159984 2016
10
Tumour seeding in the surgical pathway after resection of skull base chordoma. 38
27330428 2016
11
Bone invasiveness is associated with prognosis in clivus chordomas. 38
26810468 2016
12
Establishment of clival chordoma cell line MUG-CC1 and lymphoblastoid cells as a model for potential new treatment strategies. 38
27072875 2016
13
Sustained response of a clivus chordoma to erlotinib after imatinib failure. 38
25762924 2015
14
Experimental study on differences in clivus chordoma bone invasion: an iTRAQ-based quantitative proteomic analysis. 38
25793716 2015
15
Benign and malignant diseases of the clivus. 38
25168701 2014
16
Augmented reality-assisted skull base surgery. 38
25245926 2014
17
A case of chordoma invading multiple neuroaxial bones: report of ten years follow up. 38
24101282 2013
18
[A case of clivus chordoma with first appearance of sudden deafness]. 38
23002653 2012
19
WE-G-BRCD-02: Speed Up Standard Optimization of IMPT Treatment Planning Through the Application of GPUs. 38
28519616 2012
20
On "clivus chordoma: is it enough to image the primary site?" (skull base 2010;20:111-113). 38
22470272 2011
21
The transnasal transclival approach for clivus chordoma. 38
21302187 2010
22
Clivus chordoma: is it enough to image the primary site? 38
20808536 2010
23
[Intracranial tumors in patients referred for optical coherence tomography examination as glaucoma suspects: case report]. 38
20027414 2009
24
Clivus metastases: report of seven patients and literature review. 38
19259614 2009
25
Clivus chordoma in continuity with a large pontine cyst. 38
19721775 2009
26
[Endoscopic endonasal surgery for extrasellar tumors: case presentation and its future perspective]. 38
19306643 2009
27
Surgical approaches: postoperative care and complications "posterolateral-far lateral transcondylar approach to the ventral foramen magnum and upper cervical spinal canal". 38
18365213 2008
28
Fusions at the craniovertebral junction. 38
18389260 2008
29
[Limitation of medical treatment and ethics in chronic recurrent Clivus chordoma]. 38
19165442 2008
30
[A preliminary study of endoscopic transoral trans-posteriorwall pharynx resection of hypo-clivus chordoma]. 38
17923047 2007
31
Infantile clivus chordoma without clivus involvement: case report and review of the literature. 38
16565853 2006
32
Recurrent and metastatic clivus chordoma: systemic palliative therapy retards disease progression. 38
16222158 2005
33
Clivus chordoma associated with a pontine arachnoid cyst. 38
15992705 2005
34
Visual complications of proton beam therapy for clival chordoma. 38
12724692 2003
35
Endoscopic endonasal transsphenoidal approach: outcome analysis of 100 consecutive procedures. 38
12494353 2002
36
Endoscopically assisted transoral-transpharyngeal approach to the craniovertebral junction. 38
12234431 2002
37
Candida albicans granuloma imitate clivus chordoma. 38
12111509 2002
38
Photophobia as the presenting visual symptom of chiasmal compression. 38
11937897 2002
39
Does the tuberous sclerosis complex include clivus chordoma? A case report. 38
11271387 2001
40
A tumor suppressor locus in familial and sporadic chordoma maps to 1p36. 38
10861454 2000
41
[Transoral microsurgical treatment of craniocervical malformation]. 38
11832004 2000
42
[Intradural clivus chordoma: surgical treatment with no tumor regrowth 12 years after surgery]. 38
10909291 2000
43
First cytogenetic study of a recurrent familial chordoma of the clivus. 38
10077147 1999
44
Clinical results of the transoral operation for lesions of the craniovertebral junction and its abnormalities. 38
9952118 1999
45
Possibilities and limitations of endoscopic management of nasal and paranasal sinus malignancies. 38
10635393 1999
46
Clivus chordoma. 38
9322379 1997
47
[Preservation of olfaction in frontal transbasal approach]. 38
9218255 1997
48
Herpes simplex meningitis after surgical removal of a clivus chordoma. 38
9177973 1997
49
[Chordoma of the throat: twenty years later]. 38
9489387 1997
50
Closure of clival cerebrospinal fluid fistula with biocompatible osteoconductive polymer. 38
8166981 1994

Variations for Clivus Chordoma

Expression for Clivus Chordoma

Search GEO for disease gene expression data for Clivus Chordoma.

Pathways for Clivus Chordoma

Pathways related to Clivus Chordoma according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 PTEN IGF1R FGF2 FGF13 CXCL12 CDK4
2
Show member pathways
13.08 PTEN IGF1R FGF2 FGF13 CXCL12
3
Show member pathways
12.96 PTEN IGF1R FGF2 FGF13 CXCL12
4
Show member pathways
12.92 PTEN IGF1R FGF2 FGF13 CXCL12
5
Show member pathways
12.77 IGF1R FGF2 FGF13 CXCL12
6
Show member pathways
12.7 PTEN IGF1R FGF2 CDK4
7
Show member pathways
12.69 PTEN FGF2 CXCL12 CDK4
8
Show member pathways
12.45 PTEN IGF1R FGF2 FGF13 CXCL12
9
Show member pathways
12.34 PTEN IGF1R FGF2 CDK4
10
Show member pathways
12.3 PTEN IGF1R FGF2 CDK4
11
Show member pathways
12.03 IGF1R FGF2 FGF13 CXCL12
12 11.97 IGF1R HOXA9 HOXA10
13
Show member pathways
11.94 PTEN IGF1R CDK4
14 11.84 PTEN IGF1R CDK4
15
Show member pathways
11.77 IGF1R FGF2 FGF13 CXCL12
16 11.74 PTEN IGF1R FGF2 CXCL12 CDK4
17 11.54 PTEN IGF1R CDK4
18 11.27 IGF1R FGF2
19 11.26 PTEN CDK4
20 11.05 FGF2 CXCL12
21 11.04 PTEN IGF1R
22 10.95 IGF1R FGF2 FGF13 CXCL12
23 10.7 IGF1R FGF2 FGF13 CXCL12

GO Terms for Clivus Chordoma

Cellular components related to Clivus Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.8 HOXA9 HOXA10 CDK4

Biological processes related to Clivus Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.54 PTEN HOXA7 FGF2
2 regulation of gene expression GO:0010468 9.5 HOXA9 HOXA10 CDK4
3 animal organ regeneration GO:0031100 9.43 CXCL12 CDK4
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.4 PTEN FGF2
5 proximal/distal pattern formation GO:0009954 9.26 HOXA9 HOXA10
6 uterus development GO:0060065 9.16 HOXA9 HOXA10
7 anterior/posterior pattern specification GO:0009952 9.13 HOXA9 HOXA7 HOXA10
8 positive regulation of cell proliferation GO:0008284 9.02 PTEN IGF1R FGF2 CXCL12 CDK4

Molecular functions related to Clivus Chordoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.8 FGF2 FGF13 CXCL12

Sources for Clivus Chordoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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