MCID: CLC003
MIFTS: 37

Cloacogenic Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cloacogenic Carcinoma

MalaCards integrated aliases for Cloacogenic Carcinoma:

Name: Cloacogenic Carcinoma 12 15 73
Cloacogenic Anal Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7173
MeSH 44 C563020
NCIt 50 C8255
SNOMED-CT 68 84570003
UMLS 73 C0334273

Summaries for Cloacogenic Carcinoma

MalaCards based summary : Cloacogenic Carcinoma, also known as cloacogenic anal carcinoma, is related to rectal cloacogenic carcinoma and hymenolepiasis. An important gene associated with Cloacogenic Carcinoma is KERA (Keratocan), and among its related pathways/superpathways is G alpha (s) signalling events. The drugs Cisplatin and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include prostate, lung and kidney, and related phenotypes are craniofacial and digestive/alimentary

Related Diseases for Cloacogenic Carcinoma

Diseases related to Cloacogenic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 rectal cloacogenic carcinoma 12.2
2 hymenolepiasis 10.3 KRT4 KRT5
3 breast squamous cell carcinoma 10.2 KRT5 PTHLH
4 extraskeletal chondroma 10.2 PTH PTHLH
5 sclerosing hepatic carcinoma 10.2 PTH PTHLH
6 central nervous system germ cell tumor 10.2 POMC SOX2
7 invasive malignant thymoma 10.2 PTH PTHLH
8 hypocalciuric hypercalcemia, familial, type iii 10.2 PTH PTHLH
9 clear cell adenoma 10.2 PTH PTHLH
10 scleredema adultorum 10.2 POMC PTH
11 oncogenic osteomalacia 10.2 PTH PTHLH
12 sensory organ benign neoplasm 10.2 ENO2 KRT5
13 middle ear adenoma 10.2 ENO2 KRT5
14 benign mesothelioma 10.2 HBA1 KRT5
15 cervical clear cell adenocarcinoma 10.2 ENO2 KRT5
16 atypical choroid plexus papilloma 10.2 KRT5 SOX2
17 lymphocytic hypophysitis 10.2 ENO2 POMC
18 lipoadenoma 10.2 KRT5 PTH
19 corneal dystrophy, posterior amorphous 10.2 KERA PTPRC
20 gastric squamous cell carcinoma 10.2 ENO2 KRT5
21 bronchus cancer 10.2 ENO2 POMC
22 thyroid crisis 10.2 POMC PTH
23 breast adenomyoepithelioma 10.2 ENO2 KRT5
24 breast myoepithelial neoplasm 10.2 ENO2 KRT5
25 olfactory nerve neoplasm 10.2 ENO2 POMC
26 primitive neuroectodermal tumor of the cervix uteri 10.2 ENO2 PTPRC
27 vascular hemostatic disease 10.2 F12 HBA1
28 lymphoepithelioma-like carcinoma 10.1 ENO2 KRT5
29 venous hemangioma 10.1 HBA1 SOX2
30 chorioangioma 10.1 HBA1 PTHLH
31 epidural neoplasm 10.1 CD27 KRT5 PTPRC
32 conventional fibrosarcoma 10.1 ENO2 PTPRC
33 kidney rhabdoid cancer 10.1 ENO2 PTPRC
34 endometrial small cell carcinoma 10.1 ENO2 PTPRC
35 brain sarcoma 10.1 HBA1 PTPRC
36 gastric small cell carcinoma 10.1 ENO2 PTPRC
37 glomeruloid hemangioma 10.1 HBA1 PTPRC
38 drug-induced lupus erythematosus 10.1 F12 HBA1
39 solitary osseous plasmacytoma 10.1 B2M CD27
40 prostate squamous cell carcinoma 10.1 B2M KRT5
41 dowling-degos disease 1 10.1 KRT5 POMC
42 tibial neuropathy 10.1 B2M POMC
43 large cell carcinoma 10.1 ENO2 KRT5 PTHLH
44 tarsal tunnel syndrome 10.1 B2M POMC
45 connective tissue benign neoplasm 10.1 ENO2 PTH
46 thymus lipoma 10.1 PTH PTPRC
47 extraskeletal ewing sarcoma 10.1 ENO2 PTPRC
48 uremic neuropathy 10.1 B2M PTH
49 chondroid lipoma 10.1 ENO2 HBA1
50 spondylosis 10.1 ENO2 PTH

Graphical network of the top 20 diseases related to Cloacogenic Carcinoma:



Diseases related to Cloacogenic Carcinoma

Symptoms & Phenotypes for Cloacogenic Carcinoma

MGI Mouse Phenotypes related to Cloacogenic Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.43 ENO2 KRT4 KRT5 PTH PTHLH SOX2
2 digestive/alimentary MP:0005381 9.1 B2M KRT4 KRT5 PTHLH PTPRC SOX2

Drugs & Therapeutics for Cloacogenic Carcinoma

Drugs for Cloacogenic Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2 15663-27-1 2767 441203 84093
2
Fluorouracil Approved Phase 3,Phase 2 51-21-8 3385
3 Immunosuppressive Agents Phase 3,Phase 2
4 Antimetabolites Phase 3,Phase 2
5 Immunologic Factors Phase 3,Phase 2
6 Antimetabolites, Antineoplastic Phase 3,Phase 2
7 Anti-Bacterial Agents Phase 3,Phase 2
8 Antibiotics, Antitubercular Phase 3,Phase 2
9 Mitomycins Phase 3,Phase 2
10 Alkylating Agents Phase 3,Phase 2
11 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
12
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
13
Nivolumab Approved Phase 2 946414-94-4
14
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
15
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
16
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
17 Antibodies Phase 2
18 Antibodies, Monoclonal Phase 2
19 Immunoglobulins Phase 2
20 Antineoplastic Agents, Phytogenic Phase 2
21 Antimitotic Agents Phase 2
22 Albumin-Bound Paclitaxel Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Unknown status NCT00003652 Phase 3 cisplatin;fluorouracil
2 Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Completed NCT00003596 Phase 3 cisplatin;fluorouracil;mitomycin C
3 Radiation Therapy Plus Fluorouracil With or Without Additional Chemotherapy in Treating Patients With Primary Anal Cancer Completed NCT00025090 Phase 3 cisplatin;fluorouracil;mitomycin C
4 Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer Completed NCT00423293 Phase 2 fluorouracil;mitomycin C
5 Combined Modality Therapy for Patients With With HIV and Stage I, Stage II, or Stage III Anal Cancer Completed NCT00324415 Phase 2 cisplatin;fluorouracil
6 Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer Recruiting NCT03233711 Phase 2
7 Cisplatin and Fluorouracil Compared With Carboplatin and Paclitaxel in Treating Patients With Inoperable Locally Recurrent or Metastatic Anal Cancer Active, not recruiting NCT02560298 Phase 2 Capecitabine;Carboplatin;Cisplatin;Fluorouracil;Paclitaxel
8 Cetuximab, Cisplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Anal Cancer Active, not recruiting NCT00316888 Phase 2 cisplatin;fluorouracil

Search NIH Clinical Center for Cloacogenic Carcinoma

Genetic Tests for Cloacogenic Carcinoma

Anatomical Context for Cloacogenic Carcinoma

MalaCards organs/tissues related to Cloacogenic Carcinoma:

41
Prostate, Lung, Kidney, Bone, Breast, Cervix, Thyroid

Publications for Cloacogenic Carcinoma

Articles related to Cloacogenic Carcinoma:

(show top 50) (show all 51)
# Title Authors Year
1
Molecular and immunohistochemical profile of a basaloid (cloacogenic) carcinoma of the sigmoid colon: possible predictive value for clinical outcomes. ( 24584270 )
2014
2
What is the clinicopathological characteristic of cloacogenic carcinoma outside the anorectal zone? ( 21510286 )
2011
3
Aggressive treatment approach for cloacogenic carcinoma of the anorectum: report from a single cancer center. ( 20689291 )
2010
4
Basaloid (Cloacogenic) Carcinoma Mimicking Intraabdominal Abscess: Report of a Case and Review of the Literature. ( 21103283 )
2009
5
Case report of long term survivor of metastatic cloacogenic carcinoma of the anal canal with chemotherapy. ( 20084726 )
2007
6
An unusual location of cloacogenic carcinoma. ( 10096758 )
1998
7
Inflammatory cutaneous metastases from cloacogenic carcinoma of the anus. ( 7633821 )
1995
8
Mixed cloacogenic carcinoma of male urethra. ( 1737633 )
1992
9
Transitional cloacogenic carcinoma of the female urethra treated with external irradiation and afterloading with cobalt-60. ( 2024362 )
1991
10
Cloacogenic carcinoma of the anal canal and associated viral lesions. An in situ hybridization study for human papilloma virus. ( 1657356 )
1991
11
Cytokeratin polypeptide expression in a cloacogenic carcinoma and in the normal anal canal epithelium. ( 1709765 )
1991
12
Multicentric cloacogenic carcinoma: report of a case with anogenital pruritus at presentation. ( 2229531 )
1990
13
Neurologic complications of cloacogenic carcinoma. ( 2389732 )
1990
14
Prostatic acid phosphatase in cloacogenic carcinoma. ( 2223150 )
1990
15
Simultaneous cloacogenic carcinoma in dizygotic twins. ( 3815298 )
1987
16
Small cell neuroendocrine carcinoma of the colon and rectum: clinical, histologic, and ultrastructural study and immunohistochemical comparison with cloacogenic carcinoma. ( 2434408 )
1987
17
Basal cell carcinoma of the anus: clinical and pathological distinction from cloacogenic carcinoma. ( 6501831 )
1984
18
Regression of pulmonary metastases from cloacogenic carcinoma after cis-platinum/5-fluorouracil treatment. ( 6539351 )
1984
19
An unusual type of cytokeratin filament in cells of a human cloacogenic carcinoma derived from the anorectal transition zone. ( 6179812 )
1982
20
Cloacogenic carcinoma: a study of six cases and review of literature. ( 7081171 )
1982
21
Response of metastatic cloacogenic carcinoma to treatment with semustine. ( 7306917 )
1981
22
Anal cloacogenic carcinoma: classification and clinical behavior. ( 7213001 )
1981
23
Cloacogenic carcinoma. ( 7338617 )
1981
24
Perianal Paget's disease associated with cloacogenic carcinoma: report of a case. ( 6271515 )
1981
25
Cloacogenic carcinoma of the anus. ( 7392643 )
1980
26
Results of treatment in transitional cloacogenic carcinoma. ( 7397647 )
1980
27
Ectopic Cushing's syndrome in cloacogenic carcinoma of the anal canal: a case demonstrating APUD characteristics. ( 6113712 )
1980
28
Colonoscopic inversion in the diagnosis of cloacogenic carcinoma. ( 510887 )
1979
29
Cloacogenic carcinoma of the anorectum in homosexual men: an observation of four cases. ( 527449 )
1979
30
Cloacogenic carcinoma of the vagina. ( 761463 )
1979
31
Transitional cloacogenic carcinoma of the anus and rectum: report of three cases. ( 448760 )
1979
32
Cloacogenic carcinoma. ( 666378 )
1978
33
Histogenesis of cloacogenic carcinoma. Fine structure of anal transitional epithelium and cloacogenic carcinoma. ( 711233 )
1978
34
Metastatic cloacogenic carcinoma of the anus: sequential responses to adriamycin and cis-dichlorodiammineplatinum(II). ( 627000 )
1978
35
Transitional cloacogenic carcinoma of the anus. ( 832555 )
1977
36
Basosquamous (transitional cloacogenic) carcinoma of the sigmoid colon. ( 198090 )
1977
37
Cloacogenic carcinoma. ( 966304 )
1976
38
Transitional-cell cloacogenic carcinoma of the anal canal: Case report. ( 1159269 )
1975
39
Value of lymphography in detecting metastatic cloacogenic carcinoma. ( 4842493 )
1974
40
Radiation therapy in transitional cloacogenic carcinoma of the anorectal junction. ( 4718581 )
1973
41
Transitional cloacogenic carcinoma of the urethra. ( 4736268 )
1973
42
Cloacogenic carcinoma of the anorectal junction. Roentgenologic diagnosis. ( 5037801 )
1972
43
Cloacogenic carcinoma of the anal canal. ( 5013777 )
1972
44
Transitional-cell cloacogenic carcinoma of the perianal region, anal canal, and rectum: report of seven cases. ( 5172130 )
1971
45
The basal cell nature of the so-called transitional cloacogenic carcinoma of anus as revealed by electron microscopy. ( 5796777 )
1969
46
Cloacogenic carcinoma. ( 5811555 )
1969
47
Some unusual adult male urogenital tumors with dysontogenetic features. Reports of mesonephroma, MA1llerian carcinosarcoma, transitional cloacogenic carcinoma and nephroblastoma. ( 4289492 )
1967
48
Transitional cloacogenic carcinoma of the anal canal. Clinicopathologic study of three hundred seventy-three cases. ( 6058180 )
1967
49
Cloacogenic carcinoma of the anorectal junction. ( 5853526 )
1965
50
Transitional cell carcinoma of the rectum (cloacogenic carcinoma). Report of a case. ( 5839639 )
1965

Variations for Cloacogenic Carcinoma

Expression for Cloacogenic Carcinoma

Search GEO for disease gene expression data for Cloacogenic Carcinoma.

Pathways for Cloacogenic Carcinoma

Pathways related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.19 CALCA NPS POMC PTH PTHLH

GO Terms for Cloacogenic Carcinoma

Cellular components related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 B2M CALCA ENO2 F12 HBA1 POMC
2 extracellular region GO:0005576 9.32 B2M CALCA CD27 F12 HBA1 KERA

Biological processes related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.8 CALCA POMC PTH PTHLH
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.5 CALCA PTH PTHLH
3 leukocyte cell-cell adhesion GO:0007159 9.48 CALCA PTPRC
4 response to cadmium ion GO:0046686 9.46 B2M PTH
5 cell-cell signaling GO:0007267 9.46 CALCA POMC PTH PTHLH
6 positive regulation of T cell mediated cytotoxicity GO:0001916 9.43 B2M PTPRC
7 neuropeptide signaling pathway GO:0007218 9.43 CALCA NPS POMC
8 positive regulation of T cell differentiation GO:0045582 9.4 CD27 PTPRC
9 negative regulation of chondrocyte differentiation GO:0032331 9.37 PTH PTHLH
10 regulation of gene expression GO:0010468 9.26 PTH PTHLH PTPRC SOX2
11 cAMP metabolic process GO:0046058 8.62 PTH PTHLH

Molecular functions related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide hormone receptor binding GO:0051428 8.96 PTH PTHLH
2 hormone activity GO:0005179 8.92 CALCA POMC PTH PTHLH

Sources for Cloacogenic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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