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MCID: CLC003
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Cloacogenic Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cloacogenic Carcinoma

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MalaCards integrated aliases for Cloacogenic Carcinoma:

Name: Cloacogenic Carcinoma 12 15 74
Cloacogenic Anal Carcinoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:7173
MeSH 45 C563020
NCIt 51 C8255
SNOMED-CT 69 84570003
UMLS 74 C0334273
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Summaries for Cloacogenic Carcinoma

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MalaCards based summary : Cloacogenic Carcinoma, also known as cloacogenic anal carcinoma, is related to rectal cloacogenic carcinoma and extraskeletal chondroma. An important gene associated with Cloacogenic Carcinoma is KERA (Keratocan), and among its related pathways/superpathways is G alpha (s) signalling events. The drugs Fluorouracil and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include colon and prostate, and related phenotypes are cellular and craniofacial

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Related Diseases for Cloacogenic Carcinoma

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Diseases related to Cloacogenic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 rectal cloacogenic carcinoma 12.3
2 extraskeletal chondroma 10.4 PTH PTHLH
3 sclerosing hepatic carcinoma 10.4 PTH PTHLH
4 invasive malignant thymoma 10.4 PTH PTHLH
5 hypocalciuric hypercalcemia, familial, type iii 10.4 PTH PTHLH
6 hymenolepiasis 10.4 KRT4 KRT5
7 clear cell adenoma 10.4 PTH PTHLH
8 scleredema adultorum 10.4 POMC PTH
9 oncogenic osteomalacia 10.4 PTH PTHLH
10 breast squamous cell carcinoma 10.4 KRT5 PTHLH
11 central nervous system germ cell tumor 10.3 POMC SOX2
12 lipoadenoma 10.3 KRT5 PTH
13 thyroid crisis 10.3 POMC PTH
14 sensory organ benign neoplasm 10.3 ENO2 KRT5
15 middle ear adenoma 10.3 ENO2 KRT5
16 atypical choroid plexus papilloma 10.3 KRT5 SOX2
17 corneal dystrophy, posterior amorphous 10.3 KERA PTPRC
18 angiomyoma 10.3 ENO2 PTHLH
19 lymphocytic hypophysitis 10.3 ENO2 POMC
20 cervical clear cell adenocarcinoma 10.3 ENO2 KRT5
21 bronchus cancer 10.2 ENO2 POMC
22 thymus lipoma 10.2 PTH PTPRC
23 gastric squamous cell carcinoma 10.2 ENO2 KRT5
24 olfactory nerve neoplasm 10.2 ENO2 POMC
25 connective tissue benign neoplasm 10.2 ENO2 PTH
26 primitive neuroectodermal tumor of the cervix uteri 10.2 ENO2 PTPRC
27 breast adenomyoepithelioma 10.2 ENO2 KRT5
28 breast myoepithelial neoplasm 10.2 ENO2 KRT5
29 lymphoepithelioma-like carcinoma 10.2 ENO2 KRT5
30 conventional fibrosarcoma 10.2 ENO2 PTPRC
31 dowling-degos disease 1 10.2 KRT5 POMC
32 kidney rhabdoid cancer 10.2 ENO2 PTPRC
33 endometrial small cell carcinoma 10.2 ENO2 PTPRC
34 uremic neuropathy 10.2 B2M PTH
35 spondylosis 10.2 ENO2 PTH
36 gastric small cell carcinoma 10.2 ENO2 PTPRC
37 epidural neoplasm 10.2 CD27 KRT5 PTPRC
38 solitary osseous plasmacytoma 10.2 B2M CD27
39 extraskeletal ewing sarcoma 10.2 ENO2 PTPRC
40 tibial neuropathy 10.2 B2M POMC
41 tarsal tunnel syndrome 10.2 B2M POMC
42 prostate squamous cell carcinoma 10.1 B2M KRT5
43 large cell carcinoma 10.1 ENO2 KRT5 PTHLH
44 cervix small cell carcinoma 10.1 ENO2 POMC
45 fibrogenesis imperfecta ossium 10.1 CALCA PTH
46 meningeal melanomatosis 10.0 B2M ENO2
47 hypophosphatasia, adult 10.0 CALCA PTH
48 secondary hypertrophic osteoarthropathy 10.0 CALCA POMC
49 urinary system disease 10.0 B2M POMC PTH
50 reflex sympathetic dystrophy 10.0 CALCA NPS

Graphical network of the top 20 diseases related to Cloacogenic Carcinoma:



Diseases related to Cloacogenic Carcinoma
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Symptoms & Phenotypes for Cloacogenic Carcinoma

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MGI Mouse Phenotypes related to Cloacogenic Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 B2M CD27 ENO2 PECAM1 POMC PTH
2 craniofacial MP:0005382 9.73 ENO2 KRT4 KRT5 PTH PTHLH SOX2
3 digestive/alimentary MP:0005381 9.7 B2M KRT4 KRT5 PECAM1 PTHLH PTPRC
4 growth/size/body region MP:0005378 9.61 B2M ENO2 KRT4 KRT5 POMC PTH
5 immune system MP:0005387 9.28 B2M CD27 KERA PECAM1 POMC PTH
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Drugs & Therapeutics for Cloacogenic Carcinoma

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Drugs for Cloacogenic Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 3,Phase 2 51-21-8 3385
2
Cisplatin Approved Phase 3,Phase 2 15663-27-1 441203 84093 2767
3 Antimetabolites Phase 3,Phase 2
4 Immunosuppressive Agents Phase 3,Phase 2
5 Antimetabolites, Antineoplastic Phase 3,Phase 2
6 Immunologic Factors Phase 3,Phase 2
7 Alkylating Agents Phase 3,Phase 2
8 Antibiotics, Antitubercular Phase 3,Phase 2
9 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
10 Mitomycins Phase 3,Phase 2
11 Anti-Bacterial Agents Phase 3,Phase 2
12
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
13
nivolumab Approved Phase 2 946414-94-4
14
Carboplatin Approved Phase 2 41575-94-4 38904 10339178 498142
15
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
16
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
17 Antineoplastic Agents, Immunological Phase 2
18 Antimitotic Agents Phase 2
19 Albumin-Bound Paclitaxel Phase 2
20 Antineoplastic Agents, Phytogenic Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Unknown status NCT00003652 Phase 3 cisplatin;fluorouracil
2 Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Completed NCT00003596 Phase 3 cisplatin;fluorouracil;mitomycin C
3 Radiation Therapy Plus Fluorouracil With or Without Additional Chemotherapy in Treating Patients With Primary Anal Cancer Completed NCT00025090 Phase 3 cisplatin;fluorouracil;mitomycin C
4 Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer Completed NCT00423293 Phase 2 fluorouracil;mitomycin C
5 Combined Modality Therapy for Patients With With HIV and Stage I, Stage II, or Stage III Anal Cancer Completed NCT00324415 Phase 2 cisplatin;fluorouracil
6 Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer Recruiting NCT03233711 Phase 2
7 Cisplatin and Fluorouracil Compared With Carboplatin and Paclitaxel in Treating Patients With Inoperable Locally Recurrent or Metastatic Anal Cancer Active, not recruiting NCT02560298 Phase 2 Capecitabine;Carboplatin;Cisplatin;Fluorouracil;Paclitaxel
8 Cetuximab, Cisplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Anal Cancer Active, not recruiting NCT00316888 Phase 2 cisplatin;fluorouracil

Search NIH Clinical Center for Cloacogenic Carcinoma

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Genetic Tests for Cloacogenic Carcinoma

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Anatomical Context for Cloacogenic Carcinoma

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MalaCards organs/tissues related to Cloacogenic Carcinoma:

42
Colon, Prostate
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Publications for Cloacogenic Carcinoma

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Articles related to Cloacogenic Carcinoma:

(show top 50) (show all 51)
# Title Authors Year
1
Molecular and immunohistochemical profile of a basaloid (cloacogenic) carcinoma of the sigmoid colon: possible predictive value for clinical outcomes. ( 24584270 )
2014
2
What is the clinicopathological characteristic of cloacogenic carcinoma outside the anorectal zone? ( 21510286 )
2011
3
Aggressive treatment approach for cloacogenic carcinoma of the anorectum: report from a single cancer center. ( 20689291 )
2010
4
Basaloid (Cloacogenic) Carcinoma Mimicking Intraabdominal Abscess: Report of a Case and Review of the Literature. ( 21103283 )
2009
5
Case report of long term survivor of metastatic cloacogenic carcinoma of the anal canal with chemotherapy. ( 20084726 )
2007
6
An unusual location of cloacogenic carcinoma. ( 10096758 )
1998
7
Inflammatory cutaneous metastases from cloacogenic carcinoma of the anus. ( 7633821 )
1995
8
Mixed cloacogenic carcinoma of male urethra. ( 1737633 )
1992
9
Transitional cloacogenic carcinoma of the female urethra treated with external irradiation and afterloading with cobalt-60. ( 2024362 )
1991
10
Cloacogenic carcinoma of the anal canal and associated viral lesions. An in situ hybridization study for human papilloma virus. ( 1657356 )
1991
11
Cytokeratin polypeptide expression in a cloacogenic carcinoma and in the normal anal canal epithelium. ( 1709765 )
1991
12
Multicentric cloacogenic carcinoma: report of a case with anogenital pruritus at presentation. ( 2229531 )
1990
13
Neurologic complications of cloacogenic carcinoma. ( 2389732 )
1990
14
Prostatic acid phosphatase in cloacogenic carcinoma. ( 2223150 )
1990
15
Simultaneous cloacogenic carcinoma in dizygotic twins. ( 3815298 )
1987
16
Small cell neuroendocrine carcinoma of the colon and rectum: clinical, histologic, and ultrastructural study and immunohistochemical comparison with cloacogenic carcinoma. ( 2434408 )
1987
17
Basal cell carcinoma of the anus: clinical and pathological distinction from cloacogenic carcinoma. ( 6501831 )
1984
18
Regression of pulmonary metastases from cloacogenic carcinoma after cis-platinum/5-fluorouracil treatment. ( 6539351 )
1984
19
An unusual type of cytokeratin filament in cells of a human cloacogenic carcinoma derived from the anorectal transition zone. ( 6179812 )
1982
20
Cloacogenic carcinoma: a study of six cases and review of literature. ( 7081171 )
1982
21
Response of metastatic cloacogenic carcinoma to treatment with semustine. ( 7306917 )
1981
22
Anal cloacogenic carcinoma: classification and clinical behavior. ( 7213001 )
1981
23
Cloacogenic carcinoma. ( 7338617 )
1981
24
Perianal Paget's disease associated with cloacogenic carcinoma: report of a case. ( 6271515 )
1981
25
Cloacogenic carcinoma of the anus. ( 7392643 )
1980
26
Results of treatment in transitional cloacogenic carcinoma. ( 7397647 )
1980
27
Ectopic Cushing's syndrome in cloacogenic carcinoma of the anal canal: a case demonstrating APUD characteristics. ( 6113712 )
1980
28
Colonoscopic inversion in the diagnosis of cloacogenic carcinoma. ( 510887 )
1979
29
Cloacogenic carcinoma of the anorectum in homosexual men: an observation of four cases. ( 527449 )
1979
30
Cloacogenic carcinoma of the vagina. ( 761463 )
1979
31
Transitional cloacogenic carcinoma of the anus and rectum: report of three cases. ( 448760 )
1979
32
Cloacogenic carcinoma. ( 666378 )
1978
33
Histogenesis of cloacogenic carcinoma. Fine structure of anal transitional epithelium and cloacogenic carcinoma. ( 711233 )
1978
34
Metastatic cloacogenic carcinoma of the anus: sequential responses to adriamycin and cis-dichlorodiammineplatinum(II). ( 627000 )
1978
35
Transitional cloacogenic carcinoma of the anus. ( 832555 )
1977
36
Basosquamous (transitional cloacogenic) carcinoma of the sigmoid colon. ( 198090 )
1977
37
Cloacogenic carcinoma. ( 966304 )
1976
38
Transitional-cell cloacogenic carcinoma of the anal canal: Case report. ( 1159269 )
1975
39
Value of lymphography in detecting metastatic cloacogenic carcinoma. ( 4842493 )
1974
40
Radiation therapy in transitional cloacogenic carcinoma of the anorectal junction. ( 4718581 )
1973
41
Transitional cloacogenic carcinoma of the urethra. ( 4736268 )
1973
42
Cloacogenic carcinoma of the anorectal junction. Roentgenologic diagnosis. ( 5037801 )
1972
43
Cloacogenic carcinoma of the anal canal. ( 5013777 )
1972
44
Transitional-cell cloacogenic carcinoma of the perianal region, anal canal, and rectum: report of seven cases. ( 5172130 )
1971
45
The basal cell nature of the so-called transitional cloacogenic carcinoma of anus as revealed by electron microscopy. ( 5796777 )
1969
46
Cloacogenic carcinoma. ( 5811555 )
1969
47
Some unusual adult male urogenital tumors with dysontogenetic features. Reports of mesonephroma, MA1llerian carcinosarcoma, transitional cloacogenic carcinoma and nephroblastoma. ( 4289492 )
1967
48
Transitional cloacogenic carcinoma of the anal canal. Clinicopathologic study of three hundred seventy-three cases. ( 6058180 )
1967
49
Cloacogenic carcinoma of the anorectal junction. ( 5853526 )
1965
50
Transitional cell carcinoma of the rectum (cloacogenic carcinoma). Report of a case. ( 5839639 )
1965
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Variations for Cloacogenic Carcinoma

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Expression for Cloacogenic Carcinoma

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Search GEO for disease gene expression data for Cloacogenic Carcinoma.
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Pathways for Cloacogenic Carcinoma

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Pathways related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
G alpha (s) signalling events 67
11.19 CALCA NPS POMC PTH PTHLH
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GO Terms for Cloacogenic Carcinoma

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Cellular components related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 B2M CALCA ENO2 PECAM1 POMC PTH
2 external side of plasma membrane GO:0009897 9.46 B2M CD27 PECAM1 PTPRC
3 extracellular region GO:0005576 9.23 B2M CALCA CD27 KERA NPS POMC

Biological processes related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.78 CALCA POMC PTH PTHLH
2 cell-cell signaling GO:0007267 9.56 CALCA POMC PTH PTHLH
3 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.54 CALCA PTH PTHLH
4 neuropeptide signaling pathway GO:0007218 9.5 CALCA NPS POMC
5 response to cadmium ion GO:0046686 9.49 B2M PTH
6 positive regulation of T cell mediated cytotoxicity GO:0001916 9.46 B2M PTPRC
7 regulation of gene expression GO:0010468 9.46 PTH PTHLH PTPRC SOX2
8 positive regulation of T cell differentiation GO:0045582 9.43 CD27 PTPRC
9 negative regulation of chondrocyte differentiation GO:0032331 9.4 PTH PTHLH
10 cAMP metabolic process GO:0046058 8.96 PTH PTHLH
11 leukocyte cell-cell adhesion GO:0007159 8.8 CALCA PECAM1 PTPRC

Molecular functions related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide hormone receptor binding GO:0051428 8.96 PTH PTHLH
2 hormone activity GO:0005179 8.92 CALCA POMC PTH PTHLH
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Sources for Cloacogenic Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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