MCID: CLC003
MIFTS: 39

Cloacogenic Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cloacogenic Carcinoma

MalaCards integrated aliases for Cloacogenic Carcinoma:

Name: Cloacogenic Carcinoma 12 15 74
Cloacogenic Anal Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7173
MeSH 45 C563020
NCIt 51 C8255
SNOMED-CT 69 84570003
UMLS 74 C0334273

Summaries for Cloacogenic Carcinoma

MalaCards based summary : Cloacogenic Carcinoma, also known as cloacogenic anal carcinoma, is related to rectal cloacogenic carcinoma and extraskeletal chondroma. An important gene associated with Cloacogenic Carcinoma is KERA (Keratocan), and among its related pathways/superpathways are NF-kappaB Signaling and G alpha (s) signalling events. The drugs Fluorouracil and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, breast and prostate, and related phenotypes are cellular and craniofacial

Related Diseases for Cloacogenic Carcinoma

Diseases related to Cloacogenic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
# Related Disease Score Top Affiliating Genes
1 rectal cloacogenic carcinoma 12.3
2 extraskeletal chondroma 10.4 PTH PTHLH
3 sclerosing hepatic carcinoma 10.4 PTH PTHLH
4 invasive malignant thymoma 10.4 PTH PTHLH
5 hypocalciuric hypercalcemia, familial, type iii 10.4 PTH PTHLH
6 hymenolepiasis 10.4 KRT4 KRT5
7 scleredema adultorum 10.4 POMC PTH
8 oncogenic osteomalacia 10.4 PTH PTHLH
9 breast squamous cell carcinoma 10.4 KRT5 PTHLH
10 central nervous system germ cell tumor 10.3 POMC SOX2
11 sensory organ benign neoplasm 10.3 ENO2 KRT5
12 middle ear adenoma 10.3 ENO2 KRT5
13 lymphocytic hypophysitis 10.3 ENO2 POMC
14 primitive neuroectodermal tumor of the cervix uteri 10.3 ENO2 PTPRC
15 angiomyoma 10.3 ENO2 PTHLH
16 thyroid crisis 10.3 POMC PTH
17 bronchus cancer 10.3 ENO2 POMC
18 malignant acrospiroma 10.3 CEACAM5 KRT5
19 esophageal adenosquamous carcinoma 10.3 CEACAM5 KRT5
20 uremic neuropathy 10.3 B2M PTH
21 malignant spiradenoma 10.3 CEACAM5 KRT5
22 cervical clear cell adenocarcinoma 10.3 ENO2 KRT5
23 bile duct mucoepidermoid carcinoma 10.3 CEACAM5 KRT5
24 lipoadenoma 10.2 KRT5 PTH
25 conventional fibrosarcoma 10.2 ENO2 PTPRC
26 olfactory nerve neoplasm 10.2 ENO2 POMC
27 kidney rhabdoid cancer 10.2 ENO2 PTPRC
28 endometrial small cell carcinoma 10.2 ENO2 PTPRC
29 gastric squamous cell carcinoma 10.2 ENO2 KRT5
30 epidural neoplasm 10.2 CD27 KRT5 PTPRC
31 fibrogenesis imperfecta ossium 10.2 CALCA PTH
32 liver sarcoma 10.2 CEACAM5 PTHLH
33 orbital cyst 10.2 CEACAM5 SOX2
34 tibial neuropathy 10.2 B2M POMC
35 tarsal tunnel syndrome 10.2 B2M POMC
36 malignant biphasic mesothelioma 10.2 CEACAM5 KRT5
37 tuberculous empyema 10.2 CEACAM5 POMC
38 solitary osseous plasmacytoma 10.2 B2M CD27
39 melanotic medulloblastoma 10.2 CEACAM5 ENO2
40 connective tissue benign neoplasm 10.2 ENO2 PTH
41 lymphoepithelioma-like carcinoma 10.2 ENO2 KRT5
42 corneal dystrophy, posterior amorphous 10.2 KERA PTPRC
43 ovarian lymphoma 10.2 CEACAM5 PTPRC
44 pericardial tuberculosis 10.2 CEACAM5 POMC
45 extraskeletal ewing sarcoma 10.2 ENO2 PTPRC
46 reflex sympathetic dystrophy 10.2 CALCA NPS
47 clear cell adenoma 10.1 CEACAM5 PTH PTHLH
48 rete testis adenocarcinoma 10.1 CEACAM5 ENO2
49 thymus lipoma 10.1 PTH PTPRC
50 pancreatic somatostatinoma 10.1 CALCA ENO2

Graphical network of the top 20 diseases related to Cloacogenic Carcinoma:



Diseases related to Cloacogenic Carcinoma

Symptoms & Phenotypes for Cloacogenic Carcinoma

MGI Mouse Phenotypes related to Cloacogenic Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.91 B2M CD27 ENO2 PECAM1 POMC PTH
2 craniofacial MP:0005382 9.63 ENO2 KRT4 KRT5 PTH PTHLH SOX2
3 digestive/alimentary MP:0005381 9.5 B2M KRT4 KRT5 PECAM1 PTHLH PTPRC
4 immune system MP:0005387 9.28 B2M CD27 KERA PECAM1 POMC PTH

Drugs & Therapeutics for Cloacogenic Carcinoma

Drugs for Cloacogenic Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 3,Phase 2 51-21-8 3385
2
Cisplatin Approved Phase 3,Phase 2 15663-27-1 2767 441203 84093
3 Antimetabolites, Antineoplastic Phase 3,Phase 2
4 Immunosuppressive Agents Phase 3,Phase 2
5 Immunologic Factors Phase 3,Phase 2
6 Antimetabolites Phase 3,Phase 2
7 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
8 Alkylating Agents Phase 3,Phase 2
9 Anti-Bacterial Agents Phase 3,Phase 2
10 Mitomycins Phase 3,Phase 2
11 Antibiotics, Antitubercular Phase 3,Phase 2
12
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
13
nivolumab Approved Phase 2 946414-94-4
14
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
15
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
16
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
17 Antineoplastic Agents, Immunological Phase 2
18 Albumin-Bound Paclitaxel Phase 2
19 Antineoplastic Agents, Phytogenic Phase 2
20 Antimitotic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Unknown status NCT00003652 Phase 3 cisplatin;fluorouracil
2 Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Completed NCT00003596 Phase 3 cisplatin;fluorouracil;mitomycin C
3 Radiation Therapy Plus Fluorouracil With or Without Additional Chemotherapy in Treating Patients With Primary Anal Cancer Completed NCT00025090 Phase 3 cisplatin;fluorouracil;mitomycin C
4 Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer Completed NCT00423293 Phase 2 fluorouracil;mitomycin C
5 Combined Modality Therapy for Patients With With HIV and Stage I, Stage II, or Stage III Anal Cancer Completed NCT00324415 Phase 2 cisplatin;fluorouracil
6 Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer Recruiting NCT03233711 Phase 2
7 Cisplatin and Fluorouracil Compared With Carboplatin and Paclitaxel in Treating Patients With Inoperable Locally Recurrent or Metastatic Anal Cancer Active, not recruiting NCT02560298 Phase 2 Capecitabine;Carboplatin;Cisplatin;Fluorouracil;Paclitaxel
8 Cetuximab, Cisplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Anal Cancer Active, not recruiting NCT00316888 Phase 2 cisplatin;fluorouracil

Search NIH Clinical Center for Cloacogenic Carcinoma

Genetic Tests for Cloacogenic Carcinoma

Anatomical Context for Cloacogenic Carcinoma

MalaCards organs/tissues related to Cloacogenic Carcinoma:

42
Thyroid, Breast, Prostate, Lung, Kidney, Testis, Colon

Publications for Cloacogenic Carcinoma

Articles related to Cloacogenic Carcinoma:

(show top 50) (show all 52)
# Title Authors Year
1
Molecular and immunohistochemical profile of a basaloid (cloacogenic) carcinoma of the sigmoid colon: possible predictive value for clinical outcomes. ( 24584270 )
2014
2
What is the clinicopathological characteristic of cloacogenic carcinoma outside the anorectal zone? ( 21510286 )
2011
3
Aggressive treatment approach for cloacogenic carcinoma of the anorectum: report from a single cancer center. ( 20689291 )
2010
4
Basaloid (Cloacogenic) Carcinoma Mimicking Intraabdominal Abscess: Report of a Case and Review of the Literature. ( 21103283 )
2009
5
Case report of long term survivor of metastatic cloacogenic carcinoma of the anal canal with chemotherapy. ( 20084726 )
2007
6
An unusual location of cloacogenic carcinoma. ( 10096758 )
1998
7
Inflammatory cutaneous metastases from cloacogenic carcinoma of the anus. ( 7633821 )
1995
8
Cloacogenic anal carcinoma presenting with humoral hypercalcemia: report of a case. ( 8640024 )
1995
9
Mixed cloacogenic carcinoma of male urethra. ( 1737633 )
1992
10
Cloacogenic carcinoma of the anal canal and associated viral lesions. An in situ hybridization study for human papilloma virus. ( 1657356 )
1991
11
Cytokeratin polypeptide expression in a cloacogenic carcinoma and in the normal anal canal epithelium. ( 1709765 )
1991
12
Transitional cloacogenic carcinoma of the female urethra treated with external irradiation and afterloading with cobalt-60. ( 2024362 )
1991
13
Prostatic acid phosphatase in cloacogenic carcinoma. ( 2223150 )
1990
14
Multicentric cloacogenic carcinoma: report of a case with anogenital pruritus at presentation. ( 2229531 )
1990
15
Neurologic complications of cloacogenic carcinoma. ( 2389732 )
1990
16
Small cell neuroendocrine carcinoma of the colon and rectum: clinical, histologic, and ultrastructural study and immunohistochemical comparison with cloacogenic carcinoma. ( 2434408 )
1987
17
Simultaneous cloacogenic carcinoma in dizygotic twins. ( 3815298 )
1987
18
Basal cell carcinoma of the anus: clinical and pathological distinction from cloacogenic carcinoma. ( 6501831 )
1984
19
Regression of pulmonary metastases from cloacogenic carcinoma after cis-platinum/5-fluorouracil treatment. ( 6539351 )
1984
20
An unusual type of cytokeratin filament in cells of a human cloacogenic carcinoma derived from the anorectal transition zone. ( 6179812 )
1982
21
Cloacogenic carcinoma: a study of six cases and review of literature. ( 7081171 )
1982
22
Perianal Paget's disease associated with cloacogenic carcinoma: report of a case. ( 6271515 )
1981
23
Anal cloacogenic carcinoma: classification and clinical behavior. ( 7213001 )
1981
24
Response of metastatic cloacogenic carcinoma to treatment with semustine. ( 7306917 )
1981
25
Cloacogenic carcinoma. ( 7338617 )
1981
26
Ectopic Cushing's syndrome in cloacogenic carcinoma of the anal canal: a case demonstrating APUD characteristics. ( 6113712 )
1980
27
Cloacogenic carcinoma of the anus. ( 7392643 )
1980
28
Results of treatment in transitional cloacogenic carcinoma. ( 7397647 )
1980
29
Transitional cloacogenic carcinoma of the anus and rectum: report of three cases. ( 448760 )
1979
30
Colonoscopic inversion in the diagnosis of cloacogenic carcinoma. ( 510887 )
1979
31
Cloacogenic carcinoma of the anorectum in homosexual men: an observation of four cases. ( 527449 )
1979
32
Cloacogenic carcinoma of the vagina. ( 761463 )
1979
33
Metastatic cloacogenic carcinoma of the anus: sequential responses to adriamycin and cis-dichlorodiammineplatinum(II). ( 627000 )
1978
34
Cloacogenic carcinoma. ( 666378 )
1978
35
Histogenesis of cloacogenic carcinoma. Fine structure of anal transitional epithelium and cloacogenic carcinoma. ( 711233 )
1978
36
Basosquamous (transitional cloacogenic) carcinoma of the sigmoid colon. ( 198090 )
1977
37
Transitional cloacogenic carcinoma of the anus. ( 832555 )
1977
38
Cloacogenic carcinoma. ( 966304 )
1976
39
Transitional-cell cloacogenic carcinoma of the anal canal: Case report. ( 1159269 )
1975
40
Value of lymphography in detecting metastatic cloacogenic carcinoma. ( 4842493 )
1974
41
Radiation therapy in transitional cloacogenic carcinoma of the anorectal junction. ( 4718581 )
1973
42
Transitional cloacogenic carcinoma of the urethra. ( 4736268 )
1973
43
Cloacogenic carcinoma of the anal canal. ( 5013777 )
1972
44
Cloacogenic carcinoma of the anorectal junction. Roentgenologic diagnosis. ( 5037801 )
1972
45
Transitional-cell cloacogenic carcinoma of the perianal region, anal canal, and rectum: report of seven cases. ( 5172130 )
1971
46
The basal cell nature of the so-called transitional cloacogenic carcinoma of anus as revealed by electron microscopy. ( 5796777 )
1969
47
Cloacogenic carcinoma. ( 5811555 )
1969
48
Some unusual adult male urogenital tumors with dysontogenetic features. Reports of mesonephroma, Müllerian carcinosarcoma, transitional cloacogenic carcinoma and nephroblastoma. ( 4289492 )
1967
49
Transitional cloacogenic carcinoma of the anal canal. Clinicopathologic study of three hundred seventy-three cases. ( 6058180 )
1967
50
Transitional cell carcinoma of the rectum (cloacogenic carcinoma). Report of a case. ( 5839639 )
1965

Variations for Cloacogenic Carcinoma

Expression for Cloacogenic Carcinoma

Search GEO for disease gene expression data for Cloacogenic Carcinoma.

Pathways for Cloacogenic Carcinoma

Pathways related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.77 B2M CEACAM5 PECAM1 PTPRC
2 11.19 CALCA NPS POMC PTH PTHLH

GO Terms for Cloacogenic Carcinoma

Cellular components related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 B2M CALCA ENO2 PECAM1 POMC PTH
2 external side of plasma membrane GO:0009897 9.46 B2M CD27 PECAM1 PTPRC
3 cell surface GO:0009986 9.35 B2M CD27 CEACAM5 KRT4 PTPRC
4 extracellular region GO:0005576 9.28 B2M CALCA CD27 CEACAM5 KERA NPS

Biological processes related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.8 CALCA POMC PTH PTHLH
2 cell-cell signaling GO:0007267 9.56 CALCA POMC PTH PTHLH
3 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.54 CALCA PTH PTHLH
4 response to cadmium ion GO:0046686 9.48 B2M PTH
5 positive regulation of T cell mediated cytotoxicity GO:0001916 9.46 B2M PTPRC
6 regulation of gene expression GO:0010468 9.46 PTH PTHLH PTPRC SOX2
7 positive regulation of T cell differentiation GO:0045582 9.43 CD27 PTPRC
8 negative regulation of chondrocyte differentiation GO:0032331 9.4 PTH PTHLH
9 neuropeptide signaling pathway GO:0007218 9.32 NPS POMC
10 cAMP metabolic process GO:0046058 8.96 PTH PTHLH
11 leukocyte cell-cell adhesion GO:0007159 8.8 CALCA PECAM1 PTPRC

Molecular functions related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide hormone receptor binding GO:0051428 8.96 PTH PTHLH
2 hormone activity GO:0005179 8.92 CALCA POMC PTH PTHLH

Sources for Cloacogenic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
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31 HGMD
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34 ICD10
35 ICD10 via Orphanet
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45 MeSH
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59 OMIM via Orphanet
63 PubMed
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70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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