MCID: CLC003
MIFTS: 26

Cloacogenic Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases
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Aliases & Classifications for Cloacogenic Carcinoma

MalaCards integrated aliases for Cloacogenic Carcinoma:

Name: Cloacogenic Carcinoma 11 14 71
Cloacogenic Anal Carcinoma 11

Classifications:



External Ids:

Disease Ontology 11 DOID:7173
NCIt 49 C8255
SNOMED-CT 68 84570003
UMLS 71 C0334273

Summaries for Cloacogenic Carcinoma

MalaCards based summary: Cloacogenic Carcinoma, also known as cloacogenic anal carcinoma, is related to basaloid squamous cell carcinoma and neuroendocrine carcinoma. An important gene associated with Cloacogenic Carcinoma is KERA (Keratocan). The drugs Carboplatin and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and skin.

Related Diseases for Cloacogenic Carcinoma

Diseases related to Cloacogenic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 206)
# Related Disease Score Top Affiliating Genes
1 basaloid squamous cell carcinoma 30.3 SYP KRT5 ENO2
2 neuroendocrine carcinoma 30.1 SYP ENO2
3 basal cell carcinoma 29.8 SYP KRT5 ENO2
4 wilms tumor 1 29.7 SYP KRT5 ENO2
5 rectal cloacogenic carcinoma 11.3
6 anal canal carcinoma 10.5
7 rare tumor 10.3
8 squamous cell carcinoma 10.2
9 rectum cancer 10.2
10 papilloma 10.2
11 transitional cell carcinoma 10.2
12 parietal lobe neoplasm 10.2 KRT5 ENO2
13 vulvar apocrine adenocarcinoma 10.2 KRT5 ENO2
14 spindle cell thymoma 10.1 KRT5 ENO2
15 breast leiomyosarcoma 10.1 KRT5 ENO2
16 olfactory neuroblastoma 10.1 SYP ENO2
17 blastoma 10.1 SYP ENO2
18 malignant melanocytic neoplasm of the peripheral nerve sheath 10.1 SYP ENO2
19 anal neuroendocrine tumor 10.1 SYP ENO2
20 cerebral neuroblastoma 10.1 SYP ENO2
21 neuronal intestinal dysplasia, type b 10.1 SYP ENO2
22 thymus small cell carcinoma 10.1 SYP ENO2
23 gastric small cell carcinoma 10.1 SYP ENO2
24 optic nerve astrocytoma 10.1 SYP ENO2
25 breast neuroendocrine neoplasm 10.1 SYP ENO2
26 pineal region teratoma 10.1 SYP ENO2
27 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.1 SYP ENO2
28 cauda equina neoplasm 10.1 SYP ENO2
29 colon neuroendocrine neoplasm 10.1 SYP ENO2
30 bile duct mucinous adenocarcinoma 10.1 SYP ENO2
31 ampulla of vater benign neoplasm 10.1 SYP ENO2
32 partial cryptophthalmia 10.1 SYP ENO2
33 carotid body cancer 10.1 SYP ENO2
34 pineal region choriocarcinoma 10.1 SYP ENO2
35 neurohypophysis granular cell tumor 10.1 SYP ENO2
36 granular cell tumor 10.1 SYP ENO2
37 intracranial primitive neuroectodermal tumor 10.1 SYP ENO2
38 cerebellopontine angle primitive neuroectodermal tumor 10.1 SYP ENO2
39 auditory system cancer 10.1 SYP ENO2
40 cerebellar liponeurocytoma 10.1 SYP ENO2
41 nodular ganglioneuroblastoma 10.1 SYP ENO2
42 rectal benign neoplasm 10.1
43 ganglioneuroblastoma 10.1 SYP ENO2
44 frontal lobe neoplasm 10.1 SYP ENO2
45 lipoma of spermatic cord 10.1 SYP ENO2
46 pineocytoma 10.1 SYP ENO2
47 appendix carcinoid tumor 10.1 SYP ENO2
48 urinary bladder small cell neuroendocrine carcinoma 10.1 SYP ENO2
49 jejunal neoplasm 10.1 SYP ENO2
50 melanotic neuroectodermal tumor 10.1 SYP ENO2

Graphical network of the top 20 diseases related to Cloacogenic Carcinoma:



Diseases related to Cloacogenic Carcinoma

Symptoms & Phenotypes for Cloacogenic Carcinoma

Drugs & Therapeutics for Cloacogenic Carcinoma

Drugs for Cloacogenic Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3 41575-94-4 10339178 38904
2
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
3
Nivolumab Approved Phase 3 946414-94-4
4 Albumin-Bound Paclitaxel Phase 3
5 Antimitotic Agents Phase 3
6 Tubulin Modulators Phase 3
7 Immune Checkpoint Inhibitors Phase 3
8 Antineoplastic Agents, Immunological Phase 3
9
Mitomycin Approved Phase 2 50-07-7 5746
10
Cisplatin Approved Phase 2 15663-27-1 2767 5702198 441203
11
Fluorouracil Approved Phase 2 51-21-8 3385
12
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
13 Anti-Bacterial Agents Phase 2
14 Alkylating Agents Phase 2
15 Antibiotics, Antitubercular Phase 2
16 Antimetabolites Phase 2
17 Immunosuppressive Agents Phase 2
18 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Phase III Study of Immune Checkpoint Inhibition With Chemotherapy in Treatment-Na�ve Metastatic Anal Cancer Patients Recruiting NCT04444921 Phase 3 Carboplatin;Paclitaxel
2 A Randomized Phase III Study of Nivolumab After Combined Modality Therapy (CMT) in High Risk Anal Cancer Active, not recruiting NCT03233711 Phase 3
3 A Randomized Phase II Study De-Intensified ChemoRadiation for Early-Stage Anal Squamous Cell Carcinoma (DECREASE) Recruiting NCT04166318 Phase 2 Capecitabine;Fluorouracil;Mitomycin
4 Risk-Adapted Therapy for HIV-Associated Anal Cancer Recruiting NCT04929028 Phase 2 Capecitabine;Fluorouracil;Mitomycin
5 InterAACT - An International Multicentre Open Label Randomised Phase II Advanced Anal Cancer Trial Comparing Cisplatin Plus 5-Fluorouracil Versus Carboplatin Plus Weekly Paclitaxel in Patients With Inoperable Locally Recurrent or Metastatic Disease Active, not recruiting NCT02560298 Phase 2 Capecitabine;Carboplatin;Cisplatin;Fluorouracil;Paclitaxel

Search NIH Clinical Center for Cloacogenic Carcinoma

Genetic Tests for Cloacogenic Carcinoma

Anatomical Context for Cloacogenic Carcinoma

Organs/tissues related to Cloacogenic Carcinoma:

MalaCards : Colon, Liver, Skin

Publications for Cloacogenic Carcinoma

Articles related to Cloacogenic Carcinoma:

(show top 50) (show all 117)
# Title Authors PMID Year
1
A rare case of a superficial squamous cell carcinoma (so-called cloacogenic carcinoma) of the rectum. 62
36306057 2022
2
Role of local therapy in the management of patients with metastatic anal squamous cell carcinoma: a National Cancer Database study. 62
36388688 2022
3
HPV related cloacogenic carcinoma of the anal canal with divergent histomorphology. 62
31361242 2019
4
Survival rate variation with different histological subtypes of poor prognostic male anal squamous cell carcinoma: a population-based study. 62
29137429 2017
5
Basaloid Squamous Cell Carcinoma of the Anus Revisited. 62
26866355 2016
6
The rising incidence of anal cancer in England 1990-2010: a population-based study. 62
24410872 2014
7
Molecular and immunohistochemical profile of a basaloid (cloacogenic) carcinoma of the sigmoid colon: possible predictive value for clinical outcomes. 62
24584270 2014
8
[Hepatic cyst in a patient with anorectal cloacogenic carcinoma: metastasis or benign liver disease?]. 62
22177268 2012
9
What is the clinicopathological characteristic of cloacogenic carcinoma outside the anorectal zone? 62
21510286 2011
10
FDG-PET/CT imaging for staging and target volume delineation in conformal radiotherapy of anal carcinoma. 62
20137093 2010
11
Aggressive treatment approach for cloacogenic carcinoma of the anorectum: report from a single cancer center. 62
20689291 2010
12
Basaloid (Cloacogenic) Carcinoma Mimicking Intraabdominal Abscess: Report of a Case and Review of the Literature. 62
21103283 2009
13
PNET/Ewing's sarcoma of the rectum: a case report and review of the literature. 62
21691396 2009
14
[Protruding isolated rectal and anal neoplastic polyps removed by local transanal excision: our experience with 16 cases]. 62
18689170 2008
15
Anal canal carcinoma: experience from a single Korean institution. 62
17963341 2007
16
Case report of long term survivor of metastatic cloacogenic carcinoma of the anal canal with chemotherapy. 62
20084726 2007
17
The demographics, histopathology and patterns of treatment of anal cancer in Connecticut: 1980-2000. 62
16114640 2005
18
Chemotherapy and radiation of anal canal cancer: the first approach. 62
15137959 2004
19
HIV-positive patients with anal carcinoma have poorer treatment tolerance and outcome than HIV-negative patients. 62
11598480 2001
20
Anal carcinoma: a 15-year retrospective analysis. 62
11145292 2000
21
Extrauterine malignancies. Role of Pap smears in diagnosis and management. 62
10518134 1999
22
Cloacogenic adenocarcinoma of the vulva. 62
10419750 1999
23
An unusual location of cloacogenic carcinoma. 62
10096758 1998
24
Diagnosis and differential diagnosis of small-cell lesions of the liver. 62
9664180 1998
25
[Cancer of the anal canal]. 62
9480525 1997
26
Skin cancers associated with acquired immunodeficiency syndrome. 62
7630215 1995
27
Inflammatory cutaneous metastases from cloacogenic carcinoma of the anus. 62
7633821 1995
28
Transanal excision of rectal carcinoma. 62
7618812 1995
29
[A cloacogenic anal carcinoma in an adolescent]. 62
7612375 1995
30
Cloacogenic anal carcinoma presenting with humoral hypercalcemia: report of a case. 62
8640024 1995
31
[Cloacogenic carcinoma with reference to malignant tumors of the anal canal]. 62
7837635 1994
32
[The prognostic factors following the simultaneous radiochemotherapy of anal canal carcinoma in a multicenter series of 139 patients]. 62
8052938 1994
33
[Surgical treatment of anorectal disorders in 32 HIV-seropositive patients]. 62
8015620 1994
34
[Perianal basal cell carcinoma. Apropos of 2 cases]. 62
7702280 1994
35
[Adenocarcinoma of anal canal. Report of a case and review of the literature]. 62
7701908 1994
36
[Cloacogenic carcinoma with reference to malignant tumors of the anal canal]. 62
7736207 1994
37
[Heterotopic cloacogenic carcinoma of the lower lip]. 62
7979028 1994
38
Irradiation in the management of anal cancer with literature review. 62
8320504 1993
39
External radiation therapy without chemotherapy in the management of anal cancer. 62
8448738 1993
40
Perianal basal cell carcinoma. 62
1458647 1992
41
Surgical treatment of female urethral carcinoma. 62
1574827 1992
42
Mixed cloacogenic carcinoma of male urethra. 62
1737633 1992
43
Cloacogenic carcinoma of the anal canal and associated viral lesions. An in situ hybridization study for human papilloma virus. 62
1657356 1991
44
Newer variants and simulants of basal cell carcinoma. 62
1885825 1991
45
[Spontaneous regression of liver metastases in neuroendocrine tumors of the abdomen]. 62
2057755 1991
46
Cytokeratin polypeptide expression in a cloacogenic carcinoma and in the normal anal canal epithelium. 62
1709765 1991
47
Transitional cloacogenic carcinoma of the female urethra treated with external irradiation and afterloading with cobalt-60. 62
2024362 1991
48
Multicentric cloacogenic carcinoma: report of a case with anogenital pruritus at presentation. 62
2229531 1990
49
Neurologic complications of cloacogenic carcinoma. 62
2389732 1990
50
[A case of cloacogenic carcinoma with extra-visceral localization]. 62
2392255 1990

Variations for Cloacogenic Carcinoma

Expression for Cloacogenic Carcinoma

Search GEO for disease gene expression data for Cloacogenic Carcinoma.

Pathways for Cloacogenic Carcinoma

GO Terms for Cloacogenic Carcinoma

Molecular functions related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of skin epidermis GO:0030280 8.92 KRT5 KRT4

Sources for Cloacogenic Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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