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MCID: CLC003
MIFTS: 34

Cloacogenic Carcinoma

Categories: Gastrointestinal diseases, Cancer diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cloacogenic Carcinoma

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MalaCards integrated aliases for Cloacogenic Carcinoma:

Name: Cloacogenic Carcinoma 12 15 73
Cloacogenic Anal Carcinoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:7173
MeSH 44 C563020
NCIt 50 C8255
SNOMED-CT 68 84570003
UMLS 73 C0334273
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Summaries for Cloacogenic Carcinoma

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MalaCards based summary : Cloacogenic Carcinoma, also known as cloacogenic anal carcinoma, is related to rectal cloacogenic carcinoma and extraskeletal chondroma. An important gene associated with Cloacogenic Carcinoma is KERA (Keratocan), and among its related pathways/superpathways is G alpha (s) signalling events. The drugs Cisplatin and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include colon and prostate, and related phenotype is craniofacial.

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Related Diseases for Cloacogenic Carcinoma

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Diseases related to Cloacogenic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 rectal cloacogenic carcinoma 12.1
2 extraskeletal chondroma 10.8 PTH PTHLH
3 sclerosing hepatic carcinoma 10.8 PTH PTHLH
4 hymenolepiasis 10.8 KRT4 KRT5
5 central nervous system germ cell tumor 10.8 POMC SOX2
6 invasive malignant thymoma 10.8 PTH PTHLH
7 sensory organ benign neoplasm 10.7 ENO2 KRT5
8 breast squamous cell carcinoma 10.7 KRT5 PTHLH
9 middle ear adenoma 10.7 ENO2 KRT5
10 scleredema adultorum 10.7 POMC PTH
11 hypocalciuric hypercalcemia, familial, type iii 10.7 PTH PTHLH
12 thyroid crisis 10.7 POMC PTH
13 lymphocytic hypophysitis 10.7 ENO2 POMC
14 sarcomatoid squamous cell skin carcinoma 10.7 KRT5 PTPRC
15 pleomorphic adenoma carcinoma 10.6 ENO2 PTHLH
16 oncogenic osteomalacia 10.6 PTH PTHLH
17 esophageal adenosquamous carcinoma 10.6 CEACAM5 KRT5
18 primitive neuroectodermal tumor of the cervix uteri 10.6 ENO2 PTPRC
19 malignant spiradenoma 10.6 CEACAM5 KRT5
20 bile duct mucoepidermoid carcinoma 10.6 CEACAM5 KRT5
21 gastric squamous cell carcinoma 10.5 ENO2 KRT5
22 kidney rhabdoid cancer 10.5 ENO2 PTPRC
23 venous hemangioma 10.5 HBA1 SOX2
24 epidural neoplasm 10.5 CD27 KRT5 PTPRC
25 conventional fibrosarcoma 10.4 ENO2 PTPRC
26 liver sarcoma 10.4 CEACAM5 PTHLH
27 glomeruloid hemangioma 10.4 HBA1 PTPRC
28 tuberculous empyema 10.4 CEACAM5 POMC
29 orbital cyst 10.4 CEACAM5 SOX2
30 melanotic medulloblastoma 10.4 CEACAM5 ENO2
31 endometrial small cell carcinoma 10.4 ENO2 PTPRC
32 tibial neuropathy 10.4 B2M POMC
33 brain sarcoma 10.4 HBA1 PTPRC
34 extraosseous osteosarcoma 10.4 HBA1 PTPRC
35 tarsal tunnel syndrome 10.4 B2M POMC
36 uremic neuropathy 10.4 B2M PTH
37 jaw cancer 10.4 PTH PTHLH
38 solitary osseous plasmacytoma 10.4 B2M CD27
39 acquired metabolic disease 10.4 POMC PTH PTHLH
40 chorioangioma 10.4 HBA1 PTHLH
41 atypical choroid plexus papilloma 10.4 KRT5 SOX2
42 fibrogenesis imperfecta ossium 10.4 CALCA PTH
43 reflex sympathetic dystrophy 10.3 CALCA NPS
44 malignant biphasic mesothelioma 10.3 CEACAM5 KRT5
45 pancreatic somatostatinoma 10.3 CALCA ENO2
46 rete testis adenocarcinoma 10.3 CEACAM5 ENO2
47 pericardial tuberculosis 10.3 CEACAM5 POMC
48 secondary hypertrophic osteoarthropathy 10.3 CALCA POMC
49 duodenal somatostatinoma 10.3 CALCA ENO2
50 ovarian lymphoma 10.3 CEACAM5 PTPRC

Graphical network of the top 20 diseases related to Cloacogenic Carcinoma:



Diseases related to Cloacogenic Carcinoma
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Symptoms & Phenotypes for Cloacogenic Carcinoma

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MGI Mouse Phenotypes related to Cloacogenic Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.1 ENO2 KRT4 KRT5 PTH PTHLH SOX2
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Drugs & Therapeutics for Cloacogenic Carcinoma

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Drugs for Cloacogenic Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2 15663-27-1 84093 441203 2767
2
Fluorouracil Approved Phase 3,Phase 2 51-21-8 3385
3 Immunosuppressive Agents Phase 3,Phase 2
4 Antimetabolites Phase 3,Phase 2
5 Antimetabolites, Antineoplastic Phase 3,Phase 2
6 Alkylating Agents Phase 3,Phase 2
7 Mitomycins Phase 3,Phase 2
8 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
9 Anti-Bacterial Agents Phase 3,Phase 2
10 Antibiotics, Antitubercular Phase 3,Phase 2
11
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
12
nivolumab Approved Phase 2 946414-94-4
13
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
14
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
15
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
16 Antibodies Phase 2
17 Immunoglobulins Phase 2
18 Antibodies, Monoclonal Phase 2
19 Albumin-Bound Paclitaxel Phase 2
20 Antimitotic Agents Phase 2
21 Antineoplastic Agents, Phytogenic Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Unknown status NCT00003652 Phase 3 cisplatin;fluorouracil
2 Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Completed NCT00003596 Phase 3 cisplatin;fluorouracil;mitomycin C
3 Radiation Therapy Plus Fluorouracil With or Without Additional Chemotherapy in Treating Patients With Primary Anal Cancer Completed NCT00025090 Phase 3 cisplatin;fluorouracil;mitomycin C
4 Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer Completed NCT00423293 Phase 2 fluorouracil;mitomycin C
5 Combined Modality Therapy for Patients With With HIV and Stage I, Stage II, or Stage III Anal Cancer Completed NCT00324415 Phase 2 cisplatin;fluorouracil
6 Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer Recruiting NCT03233711 Phase 2
7 Cisplatin and Fluorouracil Compared With Carboplatin and Paclitaxel in Treating Patients With Inoperable Locally Recurrent or Metastatic Anal Cancer Active, not recruiting NCT02560298 Phase 2 Capecitabine;Carboplatin;Cisplatin;Fluorouracil;Paclitaxel
8 Cetuximab, Cisplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Anal Cancer Active, not recruiting NCT00316888 Phase 2 cisplatin;fluorouracil

Search NIH Clinical Center for Cloacogenic Carcinoma

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Genetic Tests for Cloacogenic Carcinoma

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Anatomical Context for Cloacogenic Carcinoma

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MalaCards organs/tissues related to Cloacogenic Carcinoma:

41
Colon, Prostate
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Publications for Cloacogenic Carcinoma

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Articles related to Cloacogenic Carcinoma:

(show all 50)
# Title Authors Year
1
Molecular and immunohistochemical profile of a basaloid (cloacogenic) carcinoma of the sigmoid colon: possible predictive value for clinical outcomes. ( 24584270 )
2014
2
What is the clinicopathological characteristic of cloacogenic carcinoma outside the anorectal zone? ( 21510286 )
2011
3
Aggressive treatment approach for cloacogenic carcinoma of the anorectum: report from a single cancer center. ( 20689291 )
2010
4
Basaloid (Cloacogenic) Carcinoma Mimicking Intraabdominal Abscess: Report of a Case and Review of the Literature. ( 21103283 )
2009
5
Case report of long term survivor of metastatic cloacogenic carcinoma of the anal canal with chemotherapy. ( 20084726 )
2007
6
An unusual location of cloacogenic carcinoma. ( 10096758 )
1998
7
Inflammatory cutaneous metastases from cloacogenic carcinoma of the anus. ( 7633821 )
1995
8
Mixed cloacogenic carcinoma of male urethra. ( 1737633 )
1992
9
Transitional cloacogenic carcinoma of the female urethra treated with external irradiation and afterloading with cobalt-60. ( 2024362 )
1991
10
Cloacogenic carcinoma of the anal canal and associated viral lesions. An in situ hybridization study for human papilloma virus. ( 1657356 )
1991
11
Cytokeratin polypeptide expression in a cloacogenic carcinoma and in the normal anal canal epithelium. ( 1709765 )
1991
12
Multicentric cloacogenic carcinoma: report of a case with anogenital pruritus at presentation. ( 2229531 )
1990
13
Neurologic complications of cloacogenic carcinoma. ( 2389732 )
1990
14
Prostatic acid phosphatase in cloacogenic carcinoma. ( 2223150 )
1990
15
Simultaneous cloacogenic carcinoma in dizygotic twins. ( 3815298 )
1987
16
Small cell neuroendocrine carcinoma of the colon and rectum: clinical, histologic, and ultrastructural study and immunohistochemical comparison with cloacogenic carcinoma. ( 2434408 )
1987
17
Basal cell carcinoma of the anus: clinical and pathological distinction from cloacogenic carcinoma. ( 6501831 )
1984
18
Regression of pulmonary metastases from cloacogenic carcinoma after cis-platinum/5-fluorouracil treatment. ( 6539351 )
1984
19
An unusual type of cytokeratin filament in cells of a human cloacogenic carcinoma derived from the anorectal transition zone. ( 6179812 )
1982
20
Cloacogenic carcinoma: a study of six cases and review of literature. ( 7081171 )
1982
21
Response of metastatic cloacogenic carcinoma to treatment with semustine. ( 7306917 )
1981
22
Anal cloacogenic carcinoma: classification and clinical behavior. ( 7213001 )
1981
23
Cloacogenic carcinoma. ( 7338617 )
1981
24
Perianal Paget's disease associated with cloacogenic carcinoma: report of a case. ( 6271515 )
1981
25
Cloacogenic carcinoma of the anus. ( 7392643 )
1980
26
Results of treatment in transitional cloacogenic carcinoma. ( 7397647 )
1980
27
Ectopic Cushing's syndrome in cloacogenic carcinoma of the anal canal: a case demonstrating APUD characteristics. ( 6113712 )
1980
28
Colonoscopic inversion in the diagnosis of cloacogenic carcinoma. ( 510887 )
1979
29
Cloacogenic carcinoma of the anorectum in homosexual men: an observation of four cases. ( 527449 )
1979
30
Cloacogenic carcinoma of the vagina. ( 761463 )
1979
31
Transitional cloacogenic carcinoma of the anus and rectum: report of three cases. ( 448760 )
1979
32
Cloacogenic carcinoma. ( 666378 )
1978
33
Histogenesis of cloacogenic carcinoma. Fine structure of anal transitional epithelium and cloacogenic carcinoma. ( 711233 )
1978
34
Metastatic cloacogenic carcinoma of the anus: sequential responses to adriamycin and cis-dichlorodiammineplatinum(II). ( 627000 )
1978
35
Transitional cloacogenic carcinoma of the anus. ( 832555 )
1977
36
Basosquamous (transitional cloacogenic) carcinoma of the sigmoid colon. ( 198090 )
1977
37
Cloacogenic carcinoma. ( 966304 )
1976
38
Transitional-cell cloacogenic carcinoma of the anal canal: Case report. ( 1159269 )
1975
39
Value of lymphography in detecting metastatic cloacogenic carcinoma. ( 4842493 )
1974
40
Radiation therapy in transitional cloacogenic carcinoma of the anorectal junction. ( 4718581 )
1973
41
Transitional cloacogenic carcinoma of the urethra. ( 4736268 )
1973
42
Cloacogenic carcinoma of the anorectal junction. Roentgenologic diagnosis. ( 5037801 )
1972
43
Cloacogenic carcinoma of the anal canal. ( 5013777 )
1972
44
Transitional-cell cloacogenic carcinoma of the perianal region, anal canal, and rectum: report of seven cases. ( 5172130 )
1971
45
The basal cell nature of the so-called transitional cloacogenic carcinoma of anus as revealed by electron microscopy. ( 5796777 )
1969
46
Cloacogenic carcinoma. ( 5811555 )
1969
47
Some unusual adult male urogenital tumors with dysontogenetic features. Reports of mesonephroma, MA1llerian carcinosarcoma, transitional cloacogenic carcinoma and nephroblastoma. ( 4289492 )
1967
48
Transitional cloacogenic carcinoma of the anal canal. Clinicopathologic study of three hundred seventy-three cases. ( 6058180 )
1967
49
Cloacogenic carcinoma of the anorectal junction. ( 5853526 )
1965
50
Transitional cell carcinoma of the rectum (cloacogenic carcinoma). Report of a case. ( 5839639 )
1965
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Variations for Cloacogenic Carcinoma

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Expression for Cloacogenic Carcinoma

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Search GEO for disease gene expression data for Cloacogenic Carcinoma.
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Pathways for Cloacogenic Carcinoma

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Pathways related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
G alpha (s) signalling events 66
11.19 CALCA NPS POMC PTH PTHLH
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GO Terms for Cloacogenic Carcinoma

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Cellular components related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 B2M CALCA ENO2 F12 HBA1 KERA
2 extracellular region GO:0005576 9.36 B2M CALCA CD27 CEACAM5 F12 HBA1

Biological processes related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.67 CALCA POMC PTH PTHLH
2 negative regulation of chondrocyte differentiation GO:0032331 9.4 PTH PTHLH
3 neuropeptide signaling pathway GO:0007218 9.33 CALCA NPS POMC
4 positive regulation of ossification GO:0045778 9.32 CALCA PTH
5 obsolete positive regulation of cAMP biosynthetic process GO:0030819 9.26 PTH PTHLH
6 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.13 CALCA PTH PTHLH
7 cAMP metabolic process GO:0046058 8.62 PTH PTHLH

Molecular functions related to Cloacogenic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide hormone receptor binding GO:0051428 8.96 PTH PTHLH
2 hormone activity GO:0005179 8.92 CALCA POMC PTH PTHLH
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Sources for Cloacogenic Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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