MCID: CLN003
MIFTS: 48

Clonorchiasis

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Clonorchiasis

MalaCards integrated aliases for Clonorchiasis:

Name: Clonorchiasis 12 3 45 15 17 74
Oriental Liver Fluke Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13767
ICD9CM 36 121.1
MeSH 45 D003003
SNOMED-CT 69 11938002
ICD10 34 B66.1
UMLS 74 C0009021

Summaries for Clonorchiasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Clonorchis sinensis. The symptoms include abdominal pain, nausea, diarrhea, and eosinophilia. In long-standing infections, cholangitis, cholelithiasis, pancreatitis, and cholangiocarcinoma can develop.

MalaCards based summary : Clonorchiasis, also known as oriental liver fluke disease, is related to fascioliasis and opisthorchiasis. An important gene associated with Clonorchiasis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include liver, lung and bone, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

CDC : 3 Diagnosis of Clonorchis infection is based on microscopic identification of the parasite’s eggs in stool specimens. Safe and effective medication is available to treat Clonorchis infections. Adequately freezing or cooking fish will kill the parasite.

Wikipedia : 77 Clonorchiasis is an infectious disease caused by the Chinese liver fluke, Clonorchis sinensis, and two... more...

Related Diseases for Clonorchiasis

Diseases related to Clonorchiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 270)
# Related Disease Score Top Affiliating Genes
1 fascioliasis 30.8 IFNG IL10
2 opisthorchiasis 30.5 CTSF CXCL8 TNF
3 schistosomiasis 30.2 IFNG IL10 IL2 TNF
4 parasitic helminthiasis infectious disease 30.1 IL10 IL2 TNF
5 lung disease 29.7 CXCL8 IL10 TGFB1 TNF
6 cholangiocarcinoma 10.5
7 hypersensitivity reaction type iii disease 10.4 CD79A TNF
8 osteosclerotic myeloma 10.4 CD79A TNF
9 post-transplant lymphoproliferative disease 10.4 IL10 TNF
10 autoimmune disease of eyes, ear, nose and throat 10.4 IL10 TNF
11 trachoma 10.4 IL10 TNF
12 choroiditis 10.4 IL10 TNF
13 trichuriasis 10.4 IL10 TNF
14 scrub typhus 10.4 IL10 TNF
15 multidrug-resistant tuberculosis 10.4 IL10 TNF
16 transient hypogammaglobulinemia 10.4 IL10 TNF
17 mucocutaneous leishmaniasis 10.4 IL10 TNF
18 vulvovaginal candidiasis 10.4 CD79A IL2
19 idiopathic achalasia 10.4 IL10 TNF
20 paragonimiasis 10.4
21 multifocal choroiditis 10.4 IL10 TNF
22 farmer's lung 10.4 IL2 TNF
23 burning mouth syndrome 10.4 IL2 TNF
24 gaucher disease, type ii 10.4 IL10 IL2
25 trichosporonosis 10.4 IFNG TNF
26 cytomegalovirus retinitis 10.4 IFNG TNF
27 scleritis 10.4 IFNG TNF
28 central nervous system vasculitis 10.4 IFNG TNF
29 lichen disease 10.4 IFNG TNF
30 tuberculous peritonitis 10.4 IFNG TNF
31 miliary tuberculosis 10.4 IFNG TNF
32 autoimmune myocarditis 10.4 IFNG TNF
33 soft tissue sarcoma 10.4 IFNG TNF
34 buruli ulcer 10.4 IFNG IL10
35 chronic beryllium disease 10.4 IFNG TNF
36 nickel allergic contact dermatitis 10.4 IFNG IL10
37 baylisascariasis 10.4 IFNG IL10
38 multicentric castleman disease 10.4 IFNG IL10
39 hand, foot and mouth disease 10.4 IFNG IL10
40 fungal meningitis 10.4 IFNG IL10
41 giardiasis 10.4 CD79A TGFB1
42 peanut allergy 10.4 IFNG IL10
43 pericardial tuberculosis 10.4 IFNG IL10
44 berylliosis 10.3 IFNG IL2
45 laryngitis 10.3 TGFB1 TNF
46 posterior urethral valves 10.3 TGFB1 TNF
47 oligoarticular juvenile idiopathic arthritis 10.3 TGFB1 TNF
48 atopic keratoconjunctivitis 10.3 IFNG IL2
49 fixed drug eruption 10.3 IFNG IL2
50 bacteriuria 10.3 CD79A CXCL8

Graphical network of the top 20 diseases related to Clonorchiasis:



Diseases related to Clonorchiasis

Symptoms & Phenotypes for Clonorchiasis

GenomeRNAi Phenotypes related to Clonorchiasis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 CXCL8 IL10 IL2 TGFB1 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 CXCL8 IL10 IL2 TGFB1 TNF

MGI Mouse Phenotypes related to Clonorchiasis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.95 CTSF EPG5 IFNG IL10 IL2 TGFB1
2 hematopoietic system MP:0005397 9.91 CD79A EPG5 IFNG IL10 IL2 TGFB1
3 immune system MP:0005387 9.87 CD79A EPG5 IFNG IL10 IL2 TGFB1
4 liver/biliary system MP:0005370 9.8 CD79A EPG5 IFNG IL10 IL2 TGFB1
5 neoplasm MP:0002006 9.63 CD79A IFNG IL10 IL2 TGFB1 TNF
6 nervous system MP:0003631 9.5 CD79A CTSF EPG5 IFNG IL10 TGFB1
7 no phenotypic analysis MP:0003012 9.02 CD79A IFNG IL10 IL2 TNF

Drugs & Therapeutics for Clonorchiasis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study for the Ocular Toxocariasis Patients With the Pulmonary Toxocariasis, and Ocular Toxocariasis Cohort Recruiting NCT03814837

Search NIH Clinical Center for Clonorchiasis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: clonorchiasis

Genetic Tests for Clonorchiasis

Anatomical Context for Clonorchiasis

MalaCards organs/tissues related to Clonorchiasis:

42
Liver, Lung, Bone, Testes, Skin, Pancreas, Bone Marrow

Publications for Clonorchiasis

Articles related to Clonorchiasis:

(show top 50) (show all 227)
# Title Authors Year
1
A retrospective administrative database analysis of the association between clonorchiasis or helminthiasis and the development of cholelithiasis. ( 30071748 )
2019
2
Clonorchis sinensis omega-class glutathione transferases are reliable biomarkers for serodiagnosis of clonorchiasis and opisthorchiasis. ( 29649604 )
2019
3
Clonorchiasis sinensis detected by laparoscopic exploration of biliary tracts in two patients with obstructive jaundice. ( 30621611 )
2019
4
A co-infection case report of Taenia saginata in a patient with subclinical clonorchiasis confirmed by the combination of diagnostic tools. ( 30727977 )
2019
5
Mathematical modeling the dynamics of Clonorchiasis in Guangzhou City of China. ( 30861670 )
2019
6
Clonorchiasis or Paragonimiasis? ( 29483404 )
2018
7
Reply to "Clonorchiasis or Paragonimiasis?" ( 29483405 )
2018
8
Recombinant adenylate kinase 3 from liver fluke Clonorchis sinensis for histochemical analysis and serodiagnosis of clonorchiasis. ( 29580315 )
2018
9
Characteristic imaging features of clonorchiasis. ( 29658489 )
2018
10
Clonorchis sinensis and Clonorchiasis: The Relevance of Exploring Genetic Variation. ( 29753338 )
2018
11
Modeling the Transmission Dynamics of Clonorchiasis in Foshan, China. ( 30310106 )
2018
12
Never seen before? Opisthorchiasis and Clonorchiasis. ( 30466135 )
2018
13
Risk mapping of clonorchiasis in the People's Republic of China: A systematic review and Bayesian geostatistical analysis. ( 28253272 )
2017
14
A new method for estimating the prevalence of clonorchiasis in Korea: A proposal to replace arbitrary riverside sampling. ( 28353615 )
2017
15
Epidemiological and Clinical Parameters Features of Patients with Clonorchiasis in the Geum River Basin, Republic of Korea. ( 28529523 )
2017
16
Sequence analysis and characterization of pyruvate kinase from Clonorchis sinensis, a 53.1-kDa homopentamer, implicated immune protective efficacy against clonorchiasis. ( 29121987 )
2017
17
Clonorchiasis Complicated with Diffuse Parenchymal Lung Disease in Children. ( 29176155 )
2017
18
Clonorchiasis. ( 26299184 )
2016
19
Current status of Clonorchis sinensis and clonorchiasis in China. ( 26740359 )
2016
20
Current status and perspectives of Clonorchis sinensis and clonorchiasis: epidemiology, pathogenesis, omics, prevention and control. ( 27384714 )
2016
21
Ultrasonic diagnosis of patients with clonorchiasis and preliminary study of pathogenic mechanism. ( 27393100 )
2016
22
Advanced enzymology, expression profile and immune response of Clonorchis sinensis hexokinase show its application potential for prevention and control of clonorchiasis. ( 25799453 )
2015
23
Mapping of the putative epitope domain of Clonorchis sinensis paramyosin (CsPmy) recognized by CsPmy-specific immunoglobulin G in sera of human clonorchiasis. ( 26099940 )
2015
24
Identification and characterization of Clonorchis sinensis cathepsin B proteases in the pathogenesis of clonorchiasis. ( 26691339 )
2015
25
Recognizing clonorchiasis: A foodborne illness leading to significant hepatobiliary disease. ( 31040986 )
2015
26
In vivo diagnosis of clonorchiasis during cholangioscopy for workup of suspected cholangiocarcinoma (with video). ( 24731267 )
2014
27
Identification of risk and prognostic factors for patients with clonorchiasis-associated intrahepatic cholangiocarcinoma. ( 24781504 )
2014
28
The serological diagnosis of human clonorchiasis by time-resolved fluoroimmunoassay based on GST2-specific IgG4 detection. ( 24169809 )
2014
29
Correlation between clonorchiasis incidences and climatic factors in Guangzhou, China. ( 24428903 )
2014
30
Control of clonorchiasis in Korea: effectiveness of health education for community leaders and individuals in an endemic area. ( 24862476 )
2014
31
A misdiagnosis of clonorchiasis as gallstone, leading to an unnecessary cholecystectomy: a case report. ( 24881515 )
2014
32
Clonorchiasis control: starting from awareness. ( 25243069 )
2014
33
Prevalence and risk factors of clonorchiasis among residents of riverside areas in Muju-gun, Jeollabuk-do, Korea. ( 25246718 )
2014
34
Increasing prevalence and intensity of foodborne clonorchiasis, Hengxian County, China, 1989-2011. ( 25340976 )
2014
35
Trends in prevalence of clonorchiasis among patients in Heilongjiang province, Northeast China (2009-2012): implications for monitoring and control. ( 24260354 )
2013
36
Risk factors for and prevalence of clonorchiasis in Miaoli County, Taiwan. ( 24450231 )
2013
37
Prevalence and Risk Factors of Clonorchiasis among the Populations Served by Primary Healthcare Posts along Five Major Rivers in South Korea. ( 24159525 )
2013
38
Time to tackle clonorchiasis in China. ( 23849773 )
2013
39
Clonorchis sinensis and clonorchiasis, an update. ( 21741496 )
2012
40
Clonorchiasis--a historical review of contributions of Japanese parasitologists. ( 21749930 )
2012
41
The current status of opisthorchiasis and clonorchiasis in the Mekong Basin. ( 21893213 )
2012
42
Molecular characterization and expression of a cysteine protease from Clonorchis sinensis and its application for serodiagnosis of clonorchiasis. ( 22170263 )
2012
43
Serological diagnosis of clonorchiasis: using a recombinant propeptide of cathepsin L proteinase from Clonorchis sinensis as a candidate antigen. ( 22173451 )
2012
44
A review of the control of clonorchiasis sinensis and Taenia solium taeniasis/cysticercosis in China. ( 23052782 )
2012
45
The global epidemiology of clonorchiasis and its relation with cholangiocarcinoma. ( 23849183 )
2012
46
A combination of the Kato-Katz methods and ELISA to improve the diagnosis of clonorchiasis in an endemic area, China. ( 23056547 )
2012
47
Oriental cholangiohepatitis (clonorchiasis infestation) caused by Clonorchis sinensis. ( 19959317 )
2012
48
Multiple recombinant antigens of Clonorchis sinensis for serodiagnosis of human clonorchiasis. ( 21125293 )
2011
49
Obstructive jaundice caused by Clonorchiasis-associated duodenal papillitis: a case report. ( 21218042 )
2011
50
Influencing factors for cure of clonorchiasis by praziquantel therapy: infection burden and CYP3A5 gene polymorphism. ( 21461268 )
2011

Variations for Clonorchiasis

Expression for Clonorchiasis

Search GEO for disease gene expression data for Clonorchiasis.

Pathways for Clonorchiasis

Pathways related to Clonorchiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 CD79A CTSF CXCL8 IFNG IL10 IL2
2
Show member pathways
13.54 CXCL8 IFNG IL10 IL2 TGFB1 TNF
3
Show member pathways
13.42 CXCL8 IFNG IL10 IL2 TGFB1 TNF
4
Show member pathways
13.26 CXCL8 IFNG IL10 IL2 TGFB1 TNF
5
Show member pathways
13.18 CXCL8 IL10 IL2 TGFB1 TNF
6
Show member pathways
13 CXCL8 IFNG IL10 IL2 TGFB1 TNF
7
Show member pathways
12.77 CXCL8 IFNG IL10 IL2 TGFB1 TNF
8 12.74 CXCL8 IFNG IL2 TGFB1
9
Show member pathways
12.57 CD79A IFNG IL10 IL2 TNF
10
Show member pathways
12.53 IFNG IL10 IL2 TGFB1 TNF
11
Show member pathways
12.52 IFNG IL10 IL2 TNF
12 12.48 CD79A IFNG IL10 IL2 TNF
13
Show member pathways
12.47 IFNG IL10 IL2 TGFB1 TNF
14
Show member pathways
12.24 IFNG IL2 TNF
15
Show member pathways
12.23 CXCL8 IFNG TNF
16
Show member pathways
12.21 IFNG IL10 TGFB1 TNF
17 12.18 IFNG IL10 TGFB1 TNF
18
Show member pathways
12.14 CXCL8 IFNG IL10 IL2 TGFB1 TNF
19
Show member pathways
12.13 IL10 IL2 TNF
20
Show member pathways
12.11 CXCL8 IFNG TNF
21 12.11 IFNG TGFB1 TNF
22 12.1 CXCL8 IL10 TNF
23
Show member pathways
12.02 CXCL8 IFNG IL10 IL2 TGFB1
24 11.99 IFNG TGFB1 TNF
25
Show member pathways
11.94 IFNG IL10 IL2 TGFB1 TNF
26 11.93 CXCL8 IL10 TGFB1 TNF
27 11.89 CXCL8 IFNG TGFB1
28 11.88 CXCL8 IFNG IL2 TGFB1 TNF
29 11.87 CXCL8 TGFB1 TNF
30 11.83 CXCL8 IL2 TGFB1
31 11.83 IFNG TGFB1 TNF
32 11.83 CD79A IFNG IL10 IL2 TNF
33 11.82 IFNG IL10 IL2
34 11.81 CXCL8 IFNG TGFB1 TNF
35 11.77 CXCL8 IFNG IL2
36 11.73 CXCL8 IL10 TNF
37 11.73 IFNG IL10 IL2 TNF
38 11.7 CXCL8 IFNG IL10 TGFB1 TNF
39
Show member pathways
11.69 CXCL8 IFNG IL2 TNF
40 11.66 IFNG IL2 TGFB1
41 11.64 CXCL8 TGFB1 TNF
42
Show member pathways
11.62 IFNG IL2 TNF
43 11.6 IFNG TGFB1 TNF
44
Show member pathways
11.6 CXCL8 IFNG IL2 TNF
45 11.53 IFNG IL2 TNF
46 11.52 IFNG IL10 IL2 TGFB1 TNF
47 11.51 CXCL8 IL10 TNF
48 11.48 IFNG IL10 IL2
49 11.46 IFNG IL2 TGFB1 TNF
50 11.4 IFNG IL10 IL2 TGFB1 TNF

GO Terms for Clonorchiasis

Cellular components related to Clonorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CTSF CXCL8 IFNG IL10 IL2 TGFB1

Biological processes related to Clonorchiasis according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.91 CXCL8 IFNG IL10 IL2 TNF
2 inflammatory response GO:0006954 9.86 CXCL8 IL10 TGFB1 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.81 CXCL8 IL10 TNF
4 cell cycle arrest GO:0007050 9.79 CXCL8 IFNG TGFB1
5 response to organic substance GO:0010033 9.72 IL10 TGFB1 TNF
6 positive regulation of protein phosphorylation GO:0001934 9.71 IFNG IL2 TGFB1 TNF
7 extrinsic apoptotic signaling pathway GO:0097191 9.67 IFNG TGFB1 TNF
8 osteoclast differentiation GO:0030316 9.66 TGFB1 TNF
9 negative regulation of interleukin-6 production GO:0032715 9.66 IL10 TNF
10 positive regulation of cytokine secretion GO:0050715 9.65 IL10 TNF
11 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.65 IL10 TGFB1
12 regulation of synapse organization GO:0050807 9.65 IL10 TNF
13 negative regulation of myoblast differentiation GO:0045662 9.64 TGFB1 TNF
14 leukocyte chemotaxis GO:0030595 9.64 CXCL8 IL10
15 positive regulation of osteoclast differentiation GO:0045672 9.63 IFNG TNF
16 embryonic digestive tract development GO:0048566 9.62 CXCL8 TNF
17 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IFNG TNF
18 negative regulation of growth of symbiont in host GO:0044130 9.61 IL10 TNF
19 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.6 IL10 TNF
20 positive regulation of interleukin-17 production GO:0032740 9.59 IL2 TGFB1
21 negative regulation of interleukin-17 production GO:0032700 9.58 IFNG TGFB1
22 positive regulation of regulatory T cell differentiation GO:0045591 9.58 IL2 TGFB1
23 response to molecule of bacterial origin GO:0002237 9.57 CXCL8 IL10
24 cytokine-mediated signaling pathway GO:0019221 9.55 CXCL8 IL10 IL2 TGFB1 TNF
25 endothelial cell apoptotic process GO:0072577 9.54 IL10 TNF
26 negative regulation of mitotic cell cycle GO:0045930 9.54 IL10 TGFB1 TNF
27 negative regulation of cytokine secretion involved in immune response GO:0002740 9.52 IL10 TNF
28 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.48 IFNG TNF
29 positive regulation of mononuclear cell migration GO:0071677 9.46 TGFB1 TNF
30 receptor biosynthetic process GO:0032800 9.43 IL10 TNF
31 positive regulation of protein complex assembly GO:0031334 9.43 IFNG TGFB1 TNF
32 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 IFNG TNF
33 regulation of regulatory T cell differentiation GO:0045589 9.13 IFNG IL2 TGFB1
34 regulation of signaling receptor activity GO:0010469 9.1 CXCL8 IFNG IL10 IL2 TGFB1 TNF

Molecular functions related to Clonorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 IL10 IL2 TGFB1
2 cytokine activity GO:0005125 9.1 CXCL8 IFNG IL10 IL2 TGFB1 TNF

Sources for Clonorchiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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