MCID: CLN003
MIFTS: 43

Clonorchiasis

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Clonorchiasis

MalaCards integrated aliases for Clonorchiasis:

Name: Clonorchiasis 12 3 43 15 17 71 32
Oriental Liver Fluke Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13767
ICD9CM 34 121.1
MeSH 43 D003003
SNOMED-CT 67 11938002
ICD10 32 B66.1
UMLS 71 C0009021

Summaries for Clonorchiasis

CDC : 3 Clonorchis is a liver fluke parasite that humans can get by eating raw or undercooked fish, crabs, or crayfish from areas where the parasite is found. Found across parts of Asia, Clonorchis is also known as the Chinese or oriental liver fluke. Liver flukes infect the liver, gallbladder, and bile duct in humans. While most infected persons do not show any symptoms, infections that last a long time can result in severe symptoms and serious illness. Untreated, infections may persist for up to 25–30 years, the lifespan of the parasite. Diagnosis of Clonorchis infection is based on microscopic identification of the parasite's eggs in stool specimens. Safe and effective medication is available to treat Clonorchis infections. Adequately freezing or cooking fish will kill the parasite.

MalaCards based summary : Clonorchiasis, also known as oriental liver fluke disease, is related to paragonimiasis and metagonimiasis. An important gene associated with Clonorchiasis is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include liver, testes and lung, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Clonorchis sinensis. The symptoms include abdominal pain, nausea, diarrhea, and eosinophilia. In long-standing infections, cholangitis, cholelithiasis, pancreatitis, and cholangiocarcinoma can develop.

Wikipedia : 74 Clonorchiasis is an infectious disease caused by the Chinese liver fluke, Clonorchis sinensis, and two... more...

Related Diseases for Clonorchiasis

Diseases related to Clonorchiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 388)
# Related Disease Score Top Affiliating Genes
1 paragonimiasis 31.3 IGHE EPGN CTSF
2 metagonimiasis 31.2 PARVA EPGN
3 cholangitis 31.1 TNF IL2 IL10 CXCL8
4 opisthorchiasis 30.9 TNF EPGN CXCL8 CTSF
5 obstructive jaundice 30.9 TNF IL2 CXCL8
6 cysticercosis 30.9 IL10 IGHE CTSL
7 ascaris lumbricoides infection 30.6 IFNG EPGN CXCL8
8 exanthem 30.6 TNF IL2 IL10 CXCL8
9 amebiasis 30.5 TNF CXCL8 CD79A
10 hypereosinophilic syndrome 30.5 IL2 IL10 IGHE IFNG CXCL8
11 cystic echinococcosis 30.5 IL10 IGHE IFNG
12 trichuriasis 30.4 TNF IL10 EPGN
13 atrophic gastritis 30.4 TNF IL10 CXCL8
14 echinococcosis 30.3 TNF IL10 IGHE IFNG CD79A
15 pulmonary tuberculosis 30.2 TNF IL2 IL10 IFNG
16 toxoplasmosis 30.0 TNF TGFB1 IL10 IFNG CD79A
17 lung disease 30.0 TNF TGFB1 IL10 IFNG CXCL8
18 parasitic helminthiasis infectious disease 29.7 TNF IL2 IL10 IFNG EPGN CTSL
19 diarrhea 29.7 TNF TGFB1 IL2 IL10 IFNG CXCL8
20 schistosomiasis 29.7 TNF TGFB1 LGMN IL2 IL10 IGHE
21 acute pancreatitis 29.6 TNF IL10 CXCL8 CTSB
22 fascioliasis 29.3 IL10 IFNG EPGN CTSL CTSF CTSB
23 cholangiocarcinoma 10.7
24 intrahepatic cholangiocarcinoma 10.7
25 punctate inner choroidopathy 10.6 TNF IL10
26 tropical endomyocardial fibrosis 10.6 TNF IL10
27 immunoglobulin g deficiency 10.5 IGHE CD79A
28 exercise-induced anaphylaxis 10.5 IGHE CD79A
29 multifocal choroiditis 10.5 TNF IL10
30 juvenile myasthenia gravis 10.5 TGFB1 IL10
31 dermatitis, atopic, 8 10.5 IL10 CXCL8
32 idiopathic anterior uveitis 10.5 TNF CXCL8
33 polyarticular juvenile idiopathic arthritis 10.5 TNF IFNG
34 acute transverse myelitis 10.5 IL10 CXCL8
35 autoimmune myocarditis 10.5 TNF IFNG
36 palladium allergic contact dermatitis 10.5 TNF IL10
37 angelucci's syndrome 10.5 IFNG CXCL8
38 neurosyphilis 10.5 IL10 CXCL8
39 fixed drug eruption 10.5 IL2 IFNG
40 leukoregulin 10.4 TGFB1 CXCL8
41 chronic graft versus host disease 10.4 IL10 IFNG CD79A
42 spotted fever 10.4 TNF IL10 IFNG
43 spotted fever rickettsiosis 10.4 TNF IL10 IFNG
44 haemophilus influenzae 10.4 TNF CXCL8
45 ocular toxoplasmosis 10.4 IGHE CD79A
46 chronic beryllium disease 10.4 TNF IFNG
47 transverse myelitis 10.4 TNF IL10 CXCL8
48 myelitis 10.4 TNF IL10 CXCL8
49 chlamydia pneumonia 10.4 TNF IL10 CXCL8
50 eales disease 10.4 TNF IL10 IFNG

Graphical network of the top 20 diseases related to Clonorchiasis:



Diseases related to Clonorchiasis

Symptoms & Phenotypes for Clonorchiasis

MGI Mouse Phenotypes related to Clonorchiasis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.96 CD79A EPG5 EPGN IFNG IL10 IL2
2 immune system MP:0005387 9.9 CD79A CTSB EPG5 EPGN IFNG IL10
3 liver/biliary system MP:0005370 9.56 CD79A EPG5 IFNG IL10 IL2 LGMN
4 neoplasm MP:0002006 9.17 CD79A CTSB IFNG IL10 IL2 TGFB1

Drugs & Therapeutics for Clonorchiasis

Search Clinical Trials , NIH Clinical Center for Clonorchiasis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Albendazole
Praziquantel

Cochrane evidence based reviews: clonorchiasis

Genetic Tests for Clonorchiasis

Anatomical Context for Clonorchiasis

MalaCards organs/tissues related to Clonorchiasis:

40
Liver, Testes, Lung, Bone, Skin, Eye, Thyroid

Publications for Clonorchiasis

Articles related to Clonorchiasis:

(show top 50) (show all 721)
# Title Authors PMID Year
1
The control of clonorchiasis in Guangdong province, southern China. 61
31672488 2020
2
Rapid screening of Clonorchis sinensis infection: performance of a method based on raw-freshwater fish-eating practice. 61
32007446 2020
3
Partial Characterization of Two Cathepsin D Family Aspartic Peptidases of Clonorchis sinensis. 61
31914521 2019
4
nSurveillance of clonorchiasis in China in 2016. 61
31877282 2019
5
Clonorchis sinensis and clonorchiasis. 61
31862466 2019
6
Acute shock caused by Clonorchis sinensis infection: a case report. 61
31783809 2019
7
Development of an Immunochromatographic Point-of-Care Test for Serodiagnosis of Opisthorchiasis and Clonorchiasis. 61
31482789 2019
8
Neglected tropical diseases in the People's Republic of China: progress towards elimination. 61
31578147 2019
9
Cytokine Production in Cholangiocarcinoma Cells in Response to Clonorchis sinensis Excretory-Secretory Products and Their Putative Protein Components. 61
31533404 2019
10
Harmful Parasitoses on the Russian Southern Far East under Climatic and Demographic Changes. 61
31571077 2019
11
Improving diagnostic performance of the Kato-Katz method for Clonorchis sinensis infection through multiple samples. 61
31287026 2019
12
Progress on the development of rapid diagnostic tests for foodborne neglected zoonotic helminthiases: A systematic review. 61
30946810 2019
13
[Clinical value of transient elastography (FibroScan) in detection of clonorchiasis]. 61
31544417 2019
14
A Clonorchiasis Case of a Leopard Cat, Prionailurus bengalensis euptilurus, Diagnosed by Ultrasonography and Egg Detection in Republic of Korea. 61
31284354 2019
15
[Investigation on capacity of provincial parasitic diseases control institutions in main clonorchiasis-endemic areas of China]. 61
31184056 2019
16
New insights from Opisthorchis felineus genome: update on genomics of the epidemiologically important liver flukes. 61
31117933 2019
17
Membrane-bound IgE on B cells is increased during Clonorchis sinensis infection. 61
30987761 2019
18
A retrospective administrative database analysis of the association between clonorchiasis or helminthiasis and the development of cholelithiasis. 61
30071748 2019
19
A co-infection case report of Taenia saginata in a patient with subclinical clonorchiasis confirmed by the combination of diagnostic tools. 61
30727977 2019
20
Liver Flukes: Clonorchis and Opisthorchis. 61
31297762 2019
21
Clonorchiasis sinensis detected by laparoscopic exploration of biliary tracts in two patients with obstructive jaundice. 61
30621611 2019
22
Parasitic infections and medical expenses according to Health Insurance Review Assessment claims data in South Korea, 2011-2018. 61
31770393 2019
23
Preface: Sustained cooperation on research and control of neglected tropical diseases among multisectors and multipartners across borders in Southeast Asia. 61
31530398 2019
24
Multi-disciplinary integration of networking through the RNAS+: Research on other target diseases. 61
31530397 2019
25
Mathematical modeling the dynamics of Clonorchiasis in Guangzhou City of China. 61
30861670 2019
26
Clonorchis sinensis omega-class glutathione transferases are reliable biomarkers for serodiagnosis of clonorchiasis and opisthorchiasis. 61
29649604 2019
27
Never seen before? Opisthorchiasis and Clonorchiasis. 61
30466135 2018
28
[Establishment and role of national clonorchiasis surveillance system in China]. 61
30462961 2018
29
[Analysis of current drug treatment against clonorchiasis in China]. 61
30567021 2018
30
[Epidemiological survey on clonorchiasis and awareness of prevention and control knowledge in Xinfeng County of Jiangxi Province]. 61
30567020 2018
31
Recombinant adenylate kinase 3 from liver fluke Clonorchis sinensis for histochemical analysis and serodiagnosis of clonorchiasis. 61
29580315 2018
32
Bile acids drive chemotaxis of Clonorchis sinensis juveniles to the bile duct. 61
30273341 2018
33
Modeling the Transmission Dynamics of Clonorchiasis in Foshan, China. 61
30310106 2018
34
Cs1, a Clonorchis sinensis-derived serodiagnostic antigen containing tandem repeats and a signal peptide. 61
30070987 2018
35
Venom allergen-like protein 28 in Clonorchis sinensis: four epitopes on its surface and the potential role of Cys124 for its conformational stability. 61
29876859 2018
36
Improved genomic resources and new bioinformatic workflow for the carcinogenic parasite Clonorchis sinensis: Biotechnological implications. 61
29454982 2018
37
Screening US Vietnam Veterans for Liver Fluke Exposure 5 Decades After the End of the War. 61
30034207 2018
38
Infections of Soil-Transmitted Helminth in Refugees from North Korea. 61
29996634 2018
39
Snail-borne parasitic diseases: an update on global epidemiological distribution, transmission interruption and control methods. 61
29628017 2018
40
Characteristic imaging features of clonorchiasis. 61
29658489 2018
41
Clonorchiasis or Paragonimiasis? 61
29483404 2018
42
Reply to "Clonorchiasis or Paragonimiasis?" 61
29483405 2018
43
[Stratified sampling survey of major human parasitic diseases in Henan province]. 61
29609247 2018
44
Bacillus subtilis spore with surface display of paramyosin from Clonorchis sinensis potentializes a promising oral vaccine candidate. 61
29514667 2018
45
Clonorchis sinensis adult-derived proteins elicit Th2 immune responses by regulating dendritic cells via mannose receptor. 61
29505573 2018
46
[Prevalence of Clonorchis sinensis infection and effect of albendazole treatment among residents in two communities of Zhongshan City]. 61
29770671 2018
47
Altered Gut Microbiota Composition in Subjects Infected With Clonorchis sinensis. 61
30323795 2018
48
Clonorchis sinensis and Clonorchiasis: The Relevance of Exploring Genetic Variation. 61
29753338 2018
49
Performance evaluation of existing immunoassays for Clonorchis sinensis infection in China. 61
29334990 2018
50
The geographical vector in distribution of genetic diversity for Clonorchis sinensis. 61
29167987 2018

Variations for Clonorchiasis

Expression for Clonorchiasis

Search GEO for disease gene expression data for Clonorchiasis.

Pathways for Clonorchiasis

Pathways related to Clonorchiasis according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 TNF TGFB1 LGMN IL2 IL10 IGHE
2
Show member pathways
13.34 TNF TGFB1 IL2 IL10 IGHE IFNG
3
Show member pathways
13.1 TNF TGFB1 IL2 IL10 IFNG CXCL8
4
Show member pathways
12.6 TNF IL2 IL10 IGHE IFNG CD79A
5
Show member pathways
12.58 TNF TGFB1 IL2 IL10 IFNG
6
Show member pathways
12.57 TNF TGFB1 IL2 IL10 IFNG
7 12.55 TNF IL2 IL10 IFNG CD79A
8
Show member pathways
12.35 TNF TGFB1 LGMN IL2 IL10 IFNG
9
Show member pathways
12.31 TNF IL2 IL10 CXCL8
10
Show member pathways
12.24 TNF TGFB1 IL10 IFNG
11
Show member pathways
12.22 TNF TGFB1 IL2 IL10 IFNG CXCL8
12 12.21 TNF TGFB1 IL10 IFNG
13
Show member pathways
12.14 TNF IFNG CXCL8 CTSL CTSB
14
Show member pathways
12.02 TNF IFNG CTSL CTSB
15 12.01 LGMN CTSL CTSF CTSB
16
Show member pathways
12.01 TNF TGFB1 IL2 IL10 IFNG
17 11.99 TNF IL2 IL10 CXCL8
18 11.95 TNF TGFB1 IL2 IFNG CXCL8
19 11.92 TNF IL2 IL10 IFNG CD79A
20 11.9 LGMN CTSL CTSF CTSB
21 11.89 TNF TGFB1 IL10 IGHE CXCL8
22 11.88 TNF TGFB1 CXCL8
23 11.85 TNF TGFB1 IFNG
24 11.84 TGFB1 IL2 CXCL8
25 11.81 TNF TGFB1 IL10 IFNG CXCL8
26 11.78 IL2 IFNG CXCL8
27 11.78 TNF IL2 IL10 IFNG
28 11.75 TNF IL10 CXCL8
29
Show member pathways
11.74 TNF IL2 IFNG CXCL8
30 11.73 TGFB1 PARVA CTSL
31 11.73 TNF TGFB1 IFNG CXCL8 CTSL
32 11.67 TGFB1 IL2 IFNG
33 11.65 TNF TGFB1 CXCL8
34
Show member pathways
11.65 TNF IL2 IFNG CXCL8
35
Show member pathways
11.63 TNF IL2 IFNG
36 11.61 TNF TGFB1 IFNG
37 11.59 TNF TGFB1 IL2 IL10 IFNG
38 11.54 TNF IL2 IFNG
39 11.52 TNF IL10 CXCL8
40 11.51 TNF TGFB1 IL2 IL10 IFNG
41 11.49 IL2 IL10 IFNG
42 11.49 TNF TGFB1 IL2 IFNG
43 11.37 TNF IL10 IFNG
44 11.25 TNF TGFB1 IL10 IFNG CXCL8
45 11.22 TGFB1 IL2 IFNG
46 11.18 IL2 IL10 IFNG
47 11 TNF TGFB1 IL2 IL10 CXCL8
48 10.85 TNF TGFB1
49 10.48 TNF TGFB1 IL2 IL10 IFNG

GO Terms for Clonorchiasis

Cellular components related to Clonorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.85 TNF TGFB1 IL2 IL10 IFNG EPGN
2 extracellular region GO:0005576 9.7 TNF TGFB1 LGMN IL2 IL10 IGHE
3 lysosome GO:0005764 9.65 LGMN EPG5 CTSL CTSF CTSB
4 lysosomal lumen GO:0043202 9.5 LGMN CTSL CTSF
5 endolysosome lumen GO:0036021 8.8 LGMN CTSL CTSB

Biological processes related to Clonorchiasis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 10.01 TGFB1 LGMN IL2 IFNG EPGN
2 negative regulation of gene expression GO:0010629 9.93 TNF TGFB1 LGMN IFNG
3 MAPK cascade GO:0000165 9.9 TNF TGFB1 IL2 EPGN
4 positive regulation of protein phosphorylation GO:0001934 9.84 TNF TGFB1 IL2 IFNG
5 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.82 LGMN CTSL CTSF
6 response to organic substance GO:0010033 9.8 TNF TGFB1 IL10
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.75 TNF IL2 IFNG
8 positive regulation of MAP kinase activity GO:0043406 9.73 TNF TGFB1 EPGN
9 immune response GO:0006955 9.73 TNF IL2 IL10 IFNG CXCL8 IGHE
10 extrinsic apoptotic signaling pathway GO:0097191 9.69 TNF TGFB1 IFNG
11 toll-like receptor signaling pathway GO:0002224 9.67 LGMN CTSL CTSB
12 positive regulation of interleukin-17 production GO:0032740 9.65 TGFB1 IL2
13 negative regulation of interleukin-17 production GO:0032700 9.65 TGFB1 IFNG
14 positive regulation of protein complex assembly GO:0031334 9.65 TNF TGFB1 IFNG
15 cellular response to thyroid hormone stimulus GO:0097067 9.64 CTSL CTSB
16 receptor catabolic process GO:0032801 9.64 TGFB1 LGMN
17 negative regulation of mitotic cell cycle GO:0045930 9.63 TNF TGFB1 IL10
18 positive regulation of regulatory T cell differentiation GO:0045591 9.62 TGFB1 IL2
19 response to molecule of bacterial origin GO:0002237 9.62 IL10 CXCL8
20 positive regulation of chemokine biosynthetic process GO:0045080 9.61 TNF IFNG
21 negative regulation of amyloid-beta clearance GO:1900222 9.59 TNF IFNG
22 positive regulation of MHC class II biosynthetic process GO:0045348 9.58 IL10 IFNG
23 endothelial cell apoptotic process GO:0072577 9.57 TNF IL10
24 negative regulation of cytokine secretion involved in immune response GO:0002740 9.55 TNF IL10
25 positive regulation of mononuclear cell migration GO:0071677 9.52 TNF TGFB1
26 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 TNF IFNG
27 receptor biosynthetic process GO:0032800 9.4 TNF IL10
28 positive regulation of vitamin D biosynthetic process GO:0060557 9.37 TNF IFNG
29 regulation of regulatory T cell differentiation GO:0045589 9.33 TGFB1 IL2 IFNG
30 positive regulation of nitrogen compound metabolic process GO:0051173 9.32 TNF IFNG
31 proteolysis involved in cellular protein catabolic process GO:0051603 9.26 LGMN CTSL CTSF CTSB
32 cytokine-mediated signaling pathway GO:0019221 9.1 TNF TGFB1 IL2 IL10 IGHE CXCL8

Molecular functions related to Clonorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 TGFB1 IL2 IL10 EPGN
2 cysteine-type peptidase activity GO:0008234 9.46 LGMN CTSL CTSF CTSB
3 cysteine-type endopeptidase activity GO:0004197 9.26 LGMN CTSL CTSF CTSB
4 cytokine activity GO:0005125 9.1 TNF TGFB1 IL2 IL10 IFNG CXCL8

Sources for Clonorchiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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