MCID: CLN003
MIFTS: 44

Clonorchiasis

Categories: Cancer diseases, Gastrointestinal diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Clonorchiasis

MalaCards integrated aliases for Clonorchiasis:

Name: Clonorchiasis 12 3 43 15 17 71 32
Oriental Liver Fluke Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13767
ICD9CM 34 121.1
MeSH 43 D003003
SNOMED-CT 67 11938002
ICD10 32 B66.1
UMLS 71 C0009021

Summaries for Clonorchiasis

CDC : 3 Clonorchis is a liver fluke parasite that humans can get by eating raw or undercooked fish, crabs, or crayfish from areas where the parasite is found. Found across parts of Asia, Clonorchis is also known as the Chinese or oriental liver fluke. Liver flukes infect the liver, gallbladder, and bile duct in humans. While most infected persons do not show any symptoms, infections that last a long time can result in severe symptoms and serious illness. Untreated, infections may persist for up to 25–30 years, the lifespan of the parasite. Diagnosis of Clonorchis infection is based on microscopic identification of the parasite's eggs in stool specimens. Safe and effective medication is available to treat Clonorchis infections. Adequately freezing or cooking fish will kill the parasite.

MalaCards based summary : Clonorchiasis, also known as oriental liver fluke disease, is related to metagonimiasis and cholangitis. An important gene associated with Clonorchiasis is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include liver, testes and skin, and related phenotypes are cellular and growth/size/body region

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Clonorchis sinensis. The symptoms include abdominal pain, nausea, diarrhea, and eosinophilia. In long-standing infections, cholangitis, cholelithiasis, pancreatitis, and cholangiocarcinoma can develop.

Wikipedia : 74 Clonorchiasis is an infectious disease caused by the Chinese liver fluke, Clonorchis sinensis, and two... more...

Related Diseases for Clonorchiasis

Diseases related to Clonorchiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 422)
# Related Disease Score Top Affiliating Genes
1 metagonimiasis 31.2 PARVA EPGN
2 cholangitis 31.2 TNF IL2 IL10 CXCL8
3 schistosomiasis 30.8 TNF IL2 IL10 IGHE IFNG
4 obstructive jaundice 30.8 TNF TGFB1 IL2 CXCL8
5 hypereosinophilic syndrome 30.5 IL2 IL10 IGHE IFNG CXCL8
6 amebiasis 30.5 TNF CXCL8 CD79A
7 exanthem 30.4 TNF IL2 IL10 IFNG CXCL8
8 atrophic gastritis 30.4 TNF IL10 CXCL8
9 pulmonary tuberculosis 30.3 TNF IL2 IL10 IFNG
10 ancylostomiasis 30.3 MT-CO1 EPGN
11 sparganosis 30.2 MT-CO1 CTSL
12 urticaria 30.2 TNF IL10 IGHE
13 cysticercosis 30.1 STH MT-CO1 IL10 IGHE
14 toxoplasmosis 30.1 TNF TGFB1 IL10 IFNG CD79A
15 opisthorchiasis 30.1 TNF GRN EPGN CXCL8 CTSF
16 lung disease 30.0 TNF TGFB1 IL10 IFNG CXCL8
17 paragonimiasis 30.0 STH MT-CO1 IGHE EPGN CTSL
18 acute pancreatitis 30.0 TNF IL10 CXCL8 CTSB
19 ascaris lumbricoides infection 29.9 STH IL10 IFNG EPGN CXCL8
20 echinococcosis 29.9 TNF MT-CO1 IL10 IGHE IFNG
21 cystic echinococcosis 29.9 MT-CO1 IL10 IGHE IFNG
22 diarrhea 29.8 TNF TGFB1 IL2 IL10 IFNG CXCL8
23 intestinal schistosomiasis 29.7 STH MT-CO1 IL10 EPGN
24 trichuriasis 29.7 TNF STH IL10 EPGN CXCL8
25 taeniasis 29.4 TNF STH MT-CO1 IL10 CTSL
26 parasitic helminthiasis infectious disease 28.8 TNF STH MT-CO1 IL2 IL10 EPGN
27 fascioliasis 28.2 MT-CO1 IL10 IFNG GRN EPGN CTSL
28 cholangiocarcinoma 10.7
29 intrahepatic cholangiocarcinoma 10.7
30 punctate inner choroidopathy 10.6 TNF IL10
31 tropical endomyocardial fibrosis 10.6 TNF IL10
32 multifocal choroiditis 10.5 TNF IL10
33 immunoglobulin g deficiency 10.5 IGHE CD79A
34 juvenile myasthenia gravis 10.5 TGFB1 IL10
35 autoimmune myocarditis 10.5 TNF IFNG
36 exercise-induced anaphylaxis 10.5 IGHE CD79A
37 idiopathic anterior uveitis 10.5 TNF CXCL8
38 palladium allergic contact dermatitis 10.5 TNF IL10
39 acute transverse myelitis 10.5 IL10 CXCL8
40 polyarticular juvenile idiopathic arthritis 10.5 TNF IFNG
41 fixed drug eruption 10.5 IL2 IFNG
42 neurosyphilis 10.5 IL10 CXCL8
43 chronic beryllium disease 10.5 TNF IFNG
44 chronic graft versus host disease 10.5 IL10 IFNG CD79A
45 spotted fever 10.5 TNF IL10 IFNG
46 spotted fever rickettsiosis 10.5 TNF IL10 IFNG
47 leukoregulin 10.5 TGFB1 CXCL8
48 ocular toxoplasmosis 10.5 IGHE CD79A
49 haemophilus influenzae 10.5 TNF CXCL8
50 sporotrichosis 10.4 IL10 IFNG CD79A

Graphical network of the top 20 diseases related to Clonorchiasis:



Diseases related to Clonorchiasis

Symptoms & Phenotypes for Clonorchiasis

MGI Mouse Phenotypes related to Clonorchiasis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.11 CD79A CTSB EPG5 GRN IFNG IL10
2 growth/size/body region MP:0005378 10.1 CTSB CTSF EPG5 GRN IFNG IL10
3 immune system MP:0005387 10 CD79A CTSB EPG5 EPGN GRN IFNG
4 liver/biliary system MP:0005370 9.76 CD79A EPG5 GRN IFNG IL10 IL2
5 muscle MP:0005369 9.56 EPG5 IFNG IL10 MT-CO1 PARVA R3HDML
6 neoplasm MP:0002006 9.17 CD79A CTSB IFNG IL10 IL2 TGFB1

Drugs & Therapeutics for Clonorchiasis

Search Clinical Trials , NIH Clinical Center for Clonorchiasis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Albendazole
Praziquantel

Cochrane evidence based reviews: clonorchiasis

Genetic Tests for Clonorchiasis

Anatomical Context for Clonorchiasis

MalaCards organs/tissues related to Clonorchiasis:

40
Liver, Testes, Skin, Pancreas, Bone Marrow, Bone, Lung

Publications for Clonorchiasis

Articles related to Clonorchiasis:

(show top 50) (show all 736)
# Title Authors PMID Year
1
Effectiveness of health education in improving knowledge, practice and belief related to clonorchiasis in children. 61
32278640 2020
2
Rapid screening of Clonorchis sinensis infection: Performance of a method based on raw-freshwater fish-eating practice. 61
32007446 2020
3
Fungal and Parasitic Infections of the Liver. 61
32389369 2020
4
Evaluation of immune response to Bacillus subtilis spores expressing Clonorchis sinensis serpin3. 61
32404215 2020
5
In vivo and in vitro studies using Clonorchis sinensis adult-derived total protein (CsTP) on cellular function and inflammatory effect in mouse and cell model. 61
32285266 2020
6
Amino acids serve as an important energy source for adult flukes of Clonorchis sinensis. 61
32352979 2020
7
Clonorchis sinensis secretory protein CsAg17 vaccine induces immune protection. 61
32334611 2020
8
Familial assimilation in transmission of raw-freshwater fish-eating practice leading to clonorchiasis. 61
32352962 2020
9
Review of the control of clonorchiasis in Shandong Province, China from 1962 to 2015. 61
32344009 2020
10
Surveillance of clonorchiasis in China in 2016. 61
31877282 2020
11
Clonorchis sinensis and clonorchiasis. 61
31862466 2020
12
Assessment of control strategies against Clonorchis sinensis infection based on a multi-group dynamic transmission model. 61
32218570 2020
13
Dopaminergic antagonists inhibit bile chemotaxis of adult Clonorchis sinensis and its egg production. 61
32226018 2020
14
Molecular characterization of a Trichinella spiralis elastase-1 and its potential as a diagnostic antigen for trichinellosis. 61
32093735 2020
15
The control of clonorchiasis in Guangdong province, southern China. 61
31672488 2020
16
[Value of discriminant analysis for screening of clonorchiasis sinensis]. 61
32458613 2020
17
From awareness to action: NIPD's engagement in the control of food-borne clonorchiasis. 61
32563327 2020
18
Clonorchiasis in Patients with Biliary and Pancreatic Diseases: Diagnosis and Risk Factors. 61
32185201 2020
19
Partial Characterization of Two Cathepsin D Family Aspartic Peptidases of Clonorchis sinensis. 61
31914521 2019
20
Acute shock caused by Clonorchis sinensis infection: a case report. 61
31783809 2019
21
Development of an Immunochromatographic Point-of-Care Test for Serodiagnosis of Opisthorchiasis and Clonorchiasis. 61
31482789 2019
22
Neglected tropical diseases in the People's Republic of China: progress towards elimination. 61
31578147 2019
23
[Investigation of epidemic status of clonorchiasis sinensis in western regions of Jilin Province]. 61
32468799 2019
24
Cytokine Production in Cholangiocarcinoma Cells in Response to Clonorchis sinensis Excretory-Secretory Products and Their Putative Protein Components. 61
31533404 2019
25
Harmful Parasitoses on the Russian Southern Far East under Climatic and Demographic Changes. 61
31571077 2019
26
Improving diagnostic performance of the Kato-Katz method for Clonorchis sinensis infection through multiple samples. 61
31287026 2019
27
Progress on the development of rapid diagnostic tests for foodborne neglected zoonotic helminthiases: A systematic review. 61
30946810 2019
28
[Clinical value of transient elastography (FibroScan) in detection of clonorchiasis]. 61
31544417 2019
29
A Clonorchiasis Case of a Leopard Cat, Prionailurus bengalensis euptilurus, Diagnosed by Ultrasonography and Egg Detection in Republic of Korea. 61
31284354 2019
30
[Investigation on capacity of provincial parasitic diseases control institutions in main clonorchiasis-endemic areas of China]. 61
31184056 2019
31
New insights from Opisthorchis felineus genome: update on genomics of the epidemiologically important liver flukes. 61
31117933 2019
32
Membrane-bound IgE on B cells is increased during Clonorchis sinensis infection. 61
30987761 2019
33
A retrospective administrative database analysis of the association between clonorchiasis or helminthiasis and the development of cholelithiasis. 61
30071748 2019
34
A co-infection case report of Taenia saginata in a patient with subclinical clonorchiasis confirmed by the combination of diagnostic tools. 61
30727977 2019
35
Clonorchiasis sinensis detected by laparoscopic exploration of biliary tracts in two patients with obstructive jaundice. 61
30621611 2019
36
Liver Flukes: Clonorchis and Opisthorchis. 61
31297762 2019
37
Parasitic infections and medical expenses according to Health Insurance Review Assessment claims data in South Korea, 2011-2018. 61
31770393 2019
38
Preface: Sustained cooperation on research and control of neglected tropical diseases among multisectors and multipartners across borders in Southeast Asia. 61
31530398 2019
39
Multi-disciplinary integration of networking through the RNAS+: Research on other target diseases. 61
31530397 2019
40
Mathematical modeling the dynamics of Clonorchiasis in Guangzhou City of China. 61
30861670 2019
41
Clonorchis sinensis omega-class glutathione transferases are reliable biomarkers for serodiagnosis of clonorchiasis and opisthorchiasis. 61
29649604 2019
42
Never seen before? Opisthorchiasis and Clonorchiasis. 61
30466135 2018
43
[Epidemiological survey on clonorchiasis and awareness of prevention and control knowledge in Xinfeng County of Jiangxi Province]. 61
30567020 2018
44
[Establishment and role of national clonorchiasis surveillance system in China]. 61
30462961 2018
45
[Analysis of current drug treatment against clonorchiasis in China]. 61
30567021 2018
46
Recombinant adenylate kinase 3 from liver fluke Clonorchis sinensis for histochemical analysis and serodiagnosis of clonorchiasis. 61
29580315 2018
47
Bile acids drive chemotaxis of Clonorchis sinensis juveniles to the bile duct. 61
30273341 2018
48
Modeling the Transmission Dynamics of Clonorchiasis in Foshan, China. 61
30310106 2018
49
Cs1, a Clonorchis sinensis-derived serodiagnostic antigen containing tandem repeats and a signal peptide. 61
30070987 2018
50
Venom allergen-like protein 28 in Clonorchis sinensis: four epitopes on its surface and the potential role of Cys124 for its conformational stability. 61
29876859 2018

Variations for Clonorchiasis

Expression for Clonorchiasis

Search GEO for disease gene expression data for Clonorchiasis.

Pathways for Clonorchiasis

Pathways related to Clonorchiasis according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 TNF TGFB1 IL2 IL10 IGHE IFNG
2
Show member pathways
13.33 TNF TGFB1 IL2 IL10 IGHE IFNG
3
Show member pathways
13.03 TNF TGFB1 IL2 IL10 IFNG CXCL8
4
Show member pathways
12.6 TNF IL2 IL10 IGHE IFNG CD79A
5
Show member pathways
12.6 TNF TGFB1 IL2 IL10 IFNG CXCL8
6
Show member pathways
12.57 TNF TGFB1 IL2 IL10 IFNG
7
Show member pathways
12.56 TNF TGFB1 IL2 IL10 IFNG
8 12.53 TNF IL2 IL10 IFNG CD79A
9
Show member pathways
12.31 TNF IL2 IL10 CXCL8
10
Show member pathways
12.23 TNF TGFB1 IL10 IFNG
11
Show member pathways
12.22 TNF TGFB1 IL2 IL10 IFNG CXCL8
12 12.2 TNF TGFB1 IL10 IFNG
13
Show member pathways
12.14 TNF IFNG CXCL8 CTSL CTSB
14 11.98 TNF IL2 IL10 CXCL8
15 11.97 TNF TGFB1 IL2 IFNG CXCL8
16 11.94 TNF IL2 IL10 IFNG CD79A
17 11.91 TNF TGFB1 IL10 IGHE CXCL8
18
Show member pathways
11.86 TNF TGFB1 IL2 IL10 IFNG
19 11.84 TNF TGFB1 IFNG
20 11.83 TGFB1 IL2 CXCL8
21 11.81 TNF TGFB1 IL10 IFNG CXCL8
22 11.78 TNF IL2 IL10 IFNG
23 11.77 IL2 IFNG CXCL8
24 11.74 TNF IL10 CXCL8
25
Show member pathways
11.74 TNF IL2 IFNG CXCL8
26 11.73 TNF TGFB1 IFNG CXCL8 CTSL
27 11.72 TGFB1 PARVA CTSL
28 11.66 TGFB1 IL2 IFNG
29
Show member pathways
11.65 TNF IL2 IFNG CXCL8
30 11.64 TNF TGFB1 CXCL8
31
Show member pathways
11.62 TNF IL2 IFNG
32 11.59 TNF TGFB1 IFNG
33 11.59 TNF TGFB1 IL2 IL10 IFNG
34 11.53 TNF IL2 IFNG
35 11.5 TNF IL10 CXCL8
36 11.49 TNF TGFB1 IL2 IFNG
37 11.47 IL2 IL10 IFNG
38 11.36 TNF IL10 IFNG
39 11.25 TNF TGFB1 IL10 IFNG CXCL8
40 11.21 TGFB1 IL2 IFNG
41 11.17 IL2 IL10 IFNG
42 10.99 TNF TGFB1 IL2 IL10 CXCL8
43
Show member pathways
10.91 TNF TGFB1 IL2 IL10 IFNG
44 10.48 TNF TGFB1 IL2 IL10 IFNG

GO Terms for Clonorchiasis

Cellular components related to Clonorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TNF TGFB1 R3HDML IL2 IL10 IGHE
2 lysosome GO:0005764 9.65 GRN EPG5 CTSL CTSF CTSB
3 extracellular space GO:0005615 9.4 TNF TGFB1 R3HDML IL2 IL10 IFNG
4 endolysosome lumen GO:0036021 9.16 CTSL CTSB

Biological processes related to Clonorchiasis according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.99 IL2 IGHE IFNG CTSL CD79A
2 MAPK cascade GO:0000165 9.94 TNF TGFB1 IL2 EPGN
3 positive regulation of protein phosphorylation GO:0001934 9.87 TNF TGFB1 IL2 IFNG
4 positive regulation of inflammatory response GO:0050729 9.82 TNF IL2 IFNG
5 response to organic substance GO:0010033 9.82 TNF TGFB1 IL10
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.79 TNF IL2 IFNG
7 positive regulation of epithelial cell proliferation GO:0050679 9.76 TGFB1 GRN EPGN
8 positive regulation of MAP kinase activity GO:0043406 9.75 TNF TGFB1 EPGN
9 proteolysis involved in cellular protein catabolic process GO:0051603 9.71 CTSL CTSF CTSB
10 positive regulation of protein complex assembly GO:0031334 9.7 TNF TGFB1 IFNG
11 extrinsic apoptotic signaling pathway GO:0097191 9.67 TNF TGFB1 IFNG
12 cellular response to thyroid hormone stimulus GO:0097067 9.66 CTSL CTSB
13 positive regulation of regulatory T cell differentiation GO:0045591 9.65 TGFB1 IL2
14 positive regulation of chemokine biosynthetic process GO:0045080 9.65 TNF IFNG
15 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.65 TNF TGFB1 IL10
16 response to molecule of bacterial origin GO:0002237 9.63 IL10 CXCL8
17 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.63 TNF TGFB1
18 negative regulation of mitotic cell cycle GO:0045930 9.63 TNF TGFB1 IL10
19 negative regulation of amyloid-beta clearance GO:1900222 9.62 TNF IFNG
20 positive regulation of MHC class II biosynthetic process GO:0045348 9.62 IL10 IFNG
21 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.61 TNF IFNG
22 endothelial cell apoptotic process GO:0072577 9.6 TNF IL10
23 positive regulation of mononuclear cell migration GO:0071677 9.56 TNF TGFB1
24 negative regulation of cytokine production involved in immune response GO:0002719 9.55 TNF IL10
25 positive regulation of cytokine secretion GO:0050715 9.54 TNF IL10 IFNG
26 negative regulation of cytokine secretion involved in immune response GO:0002740 9.51 TNF IL10
27 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 TNF IFNG
28 cytokine-mediated signaling pathway GO:0019221 9.43 TNF TGFB1 IL2 IL10 IGHE CXCL8
29 receptor biosynthetic process GO:0032800 9.4 TNF IL10
30 regulation of regulatory T cell differentiation GO:0045589 9.33 TGFB1 IL2 IFNG
31 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 TNF IFNG
32 positive regulation of nitrogen compound metabolic process GO:0051173 9.26 TNF IFNG
33 immune response GO:0006955 9.17 TNF IL2 IL10 IGHE IFNG CXCL8

Molecular functions related to Clonorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.35 TGFB1 IL2 IL10 GRN EPGN
2 cytokine activity GO:0005125 9.17 TNF TGFB1 IL2 IL10 IFNG GRN

Sources for Clonorchiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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