MCID: CLN003
MIFTS: 48

Clonorchiasis

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Clonorchiasis

MalaCards integrated aliases for Clonorchiasis:

Name: Clonorchiasis 12 3 44 15 73
Oriental Liver Fluke Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13767
ICD10 33 B66.1
ICD9CM 35 121.1
MeSH 44 D003003
SNOMED-CT 68 11938002
UMLS 73 C0009021

Summaries for Clonorchiasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Clonorchis sinensis. The symptoms include abdominal pain, nausea, diarrhea, and eosinophilia. In long-standing infections, cholangitis, cholelithiasis, pancreatitis, and cholangiocarcinoma can develop.

MalaCards based summary : Clonorchiasis, also known as oriental liver fluke disease, is related to opisthorchiasis and fascioliasis. An important gene associated with Clonorchiasis is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include liver, testes and lung, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

CDC : 3  

Wikipedia : 76 Clonorchiasis is an infectious disease caused by the Chinese liver fluke, Clonorchis sinensis, and two... more...

Related Diseases for Clonorchiasis

Diseases related to Clonorchiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 268)
# Related Disease Score Top Affiliating Genes
1 opisthorchiasis 30.6 CTSF CXCL8 TNF
2 fascioliasis 30.6 IFNG IL10
3 schistosomiasis 30.1 IFNG IL10 IL2 TNF
4 parasitic helminthiasis infectious disease 30.0 IL10 IL2 TNF
5 lung disease 29.8 CXCL8 IL10 TGFB1 TNF
6 cholangiocarcinoma 10.5
7 paragonimiasis 10.4
8 hypersensitivity reaction type iii disease 10.3 CD79A TNF
9 osteosclerotic myeloma 10.3 CD79A TNF
10 post-transplant lymphoproliferative disease 10.3 IL10 TNF
11 autoimmune disease of eyes, ear, nose and throat 10.3 IL10 TNF
12 trachoma 10.3 IL10 TNF
13 choroiditis 10.3 IL10 TNF
14 scrub typhus 10.3 IL10 TNF
15 multidrug-resistant tuberculosis 10.3 IL10 TNF
16 transient hypogammaglobulinemia 10.3 IL10 TNF
17 mucocutaneous leishmaniasis 10.3 IL10 TNF
18 microscopic polyangiitis 10.3 IL10 TNF
19 multifocal choroiditis 10.3 IL10 TNF
20 idiopathic achalasia 10.3 IL10 TNF
21 sebaceous gland disease 10.3 CD79A CXCL8
22 endometrial disease 10.3 CXCL8 TNF
23 louse-borne relapsing fever 10.3 CXCL8 TNF
24 dental pulp disease 10.3 CXCL8 TNF
25 glaucomatocyclitic crisis 10.3 CXCL8 TNF
26 periodontosis 10.3 CXCL8 TNF
27 haemophilus influenzae 10.3 CXCL8 TNF
28 mycobacterium abscessus 10.2 CXCL8 TNF
29 vulvovaginal candidiasis 10.2 CD79A IL2
30 funisitis 10.2 CXCL8 IL10
31 vulvovaginitis 10.2 CXCL8 IL10
32 necatoriasis 10.2 CXCL8 IL10
33 scabies 10.2 CXCL8 IL10
34 farmer's lung 10.2 IL2 TNF
35 mycetoma 10.2 CXCL8 IL10
36 neurosyphilis 10.2 CXCL8 IL10
37 burning mouth syndrome 10.2 IL2 TNF
38 acute transverse myelitis 10.2 CXCL8 IL10
39 pouchitis 10.2 CXCL8 IL10
40 gaucher disease, type ii 10.2 IL10 IL2
41 trichosporonosis 10.2 IFNG TNF
42 cytomegalovirus retinitis 10.2 IFNG TNF
43 scleritis 10.2 IFNG TNF
44 metagonimiasis 10.2
45 central nervous system vasculitis 10.2 IFNG TNF
46 capillary leak syndrome 10.2 CXCL8 IL2
47 lichen disease 10.2 IFNG TNF
48 trichomoniasis 10.2 CXCL8 IL2
49 cervicitis 10.2 CXCL8 IL2
50 tuberculous peritonitis 10.2 IFNG TNF

Graphical network of the top 20 diseases related to Clonorchiasis:



Diseases related to Clonorchiasis

Symptoms & Phenotypes for Clonorchiasis

GenomeRNAi Phenotypes related to Clonorchiasis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 CXCL8 IL10 IL2 TGFB1 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 CXCL8 IL10 IL2 TGFB1 TNF

MGI Mouse Phenotypes related to Clonorchiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.95 CTSF EPG5 IFNG IL10 IL2 TGFB1
2 hematopoietic system MP:0005397 9.91 CD79A EPG5 IFNG IL10 IL2 TGFB1
3 immune system MP:0005387 9.87 CD79A EPG5 IFNG IL10 IL2 TGFB1
4 liver/biliary system MP:0005370 9.8 CD79A EPG5 IFNG IL10 IL2 TGFB1
5 neoplasm MP:0002006 9.63 CD79A IFNG IL10 IL2 TGFB1 TNF
6 nervous system MP:0003631 9.5 CD79A CTSF EPG5 IFNG IL10 TGFB1
7 no phenotypic analysis MP:0003012 9.02 CD79A IFNG IL10 IL2 TNF

Drugs & Therapeutics for Clonorchiasis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study for the Ocular Toxocariasis Patients With the Pulmonary Toxocariasis, and Ocular Toxocariasis Cohort Recruiting NCT03814837

Search NIH Clinical Center for Clonorchiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: clonorchiasis

Genetic Tests for Clonorchiasis

Anatomical Context for Clonorchiasis

MalaCards organs/tissues related to Clonorchiasis:

41
Liver, Testes, Lung, Skin, Bone, Heart, Eye

Publications for Clonorchiasis

Articles related to Clonorchiasis:

(show top 50) (show all 223)
# Title Authors Year
1
Characteristic imaging features of clonorchiasis. ( 29658489 )
2018
2
Clonorchiasis or Paragonimiasis? ( 29483404 )
2018
3
Reply to "Clonorchiasis or Paragonimiasis?" ( 29483405 )
2018
4
Clonorchis sinensis and Clonorchiasis: The Relevance of Exploring Genetic Variation. ( 29753338 )
2018
5
Recombinant adenylate kinase 3 from liver fluke Clonorchis sinensis for histochemical analysis and serodiagnosis of clonorchiasis. ( 29580315 )
2018
6
Clonorchis sinensis omega-class glutathione transferases are reliable biomarkers for serodiagnosis of clonorchiasis and opisthorchiasis. ( 29649604 )
2018
7
A retrospective administrative database analysis of the association between clonorchiasis or helminthiasis and the development of cholelithiasis. ( 30071748 )
2018
8
Modeling the Transmission Dynamics of Clonorchiasis in Foshan, China. ( 30310106 )
2018
9
Never seen before? Opisthorchiasis and Clonorchiasis. ( 30466135 )
2018
10
Sequence analysis and characterization of pyruvate kinase from Clonorchis sinensis, a 53.1-kDa homopentamer, implicated immune protective efficacy against clonorchiasis. ( 29121987 )
2017
11
Epidemiological and Clinical Parameters Features of Patients with Clonorchiasis in the Geum River Basin, Republic of Korea. ( 28529523 )
2017
12
A new method for estimating the prevalence of clonorchiasis in Korea: A proposal to replace arbitrary riverside sampling. ( 28353615 )
2017
13
Risk mapping of clonorchiasis in the People's Republic of China: A systematic review and Bayesian geostatistical analysis. ( 28253272 )
2017
14
Clonorchiasis Complicated with Diffuse Parenchymal Lung Disease in Children. ( 29176155 )
2017
15
Ultrasonic diagnosis of patients with clonorchiasis and preliminary study of pathogenic mechanism. ( 27393100 )
2016
16
Current status of Clonorchis sinensis and clonorchiasis in China. ( 26740359 )
2016
17
Current status and perspectives of Clonorchis sinensis and clonorchiasis: epidemiology, pathogenesis, omics, prevention and control. ( 27384714 )
2016
18
Advanced Enzymology, Expression Profile and Immune Response of Clonorchis sinensis Hexokinase Show Its Application Potential for Prevention and Control of Clonorchiasis. ( 25799453 )
2015
19
Clonorchiasis. ( 26299184 )
2015
20
Mapping of the putative epitope domain of Clonorchis sinensis paramyosin (CsPmy) recognized by CsPmy-specific immunoglobulin G in sera of human clonorchiasis. ( 26099940 )
2015
21
Identification and characterization of Clonorchis sinensis cathepsin B proteases in the pathogenesis of clonorchiasis. ( 26691339 )
2015
22
In vivo diagnosis of clonorchiasis during cholangioscopy for workup of suspected cholangiocarcinoma (with video). ( 24731267 )
2014
23
Increasing prevalence and intensity of foodborne clonorchiasis, hengxian county, china, 1989-2011. ( 25340976 )
2014
24
Clonorchiasis control: starting from awareness. ( 25243069 )
2014
25
Correlation between clonorchiasis incidences and climatic factors in Guangzhou, China. ( 24428903 )
2014
26
The serological diagnosis of human clonorchiasis by time-resolved fluoroimmunoassay based on GST2-specific IgG4 detection. ( 24169809 )
2014
27
Identification of risk and prognostic factors for patients with clonorchiasis-associated intrahepatic cholangiocarcinoma. ( 24781504 )
2014
28
Control of clonorchiasis in Korea: effectiveness of health education for community leaders and individuals in an endemic area. ( 24862476 )
2014
29
Prevalence and risk factors of clonorchiasis among residents of riverside areas in Muju-gun, Jeollabuk-do, Korea. ( 25246718 )
2014
30
A misdiagnosis of clonorchiasis as gallstone, leading to an unnecessary cholecystectomy: a case report. ( 24881515 )
2014
31
Prevalence and Risk Factors of Clonorchiasis among the Populations Served by Primary Healthcare Posts along Five Major Rivers in South Korea. ( 24159525 )
2013
32
Risk factors for and prevalence of clonorchiasis in Miaoli County, Taiwan. ( 24450231 )
2013
33
Trends in prevalence of clonorchiasis among patients in Heilongjiang province, Northeast China (2009-2012): implications for monitoring and control. ( 24260354 )
2013
34
Time to tackle clonorchiasis in China. ( 23849773 )
2013
35
Serological diagnosis of clonorchiasis: using a recombinant propeptide of cathepsin L proteinase from Clonorchis sinensis as a candidate antigen. ( 22173451 )
2012
36
Oriental cholangiohepatitis (clonorchiasis infestation) caused by Clonorchis sinensis. ( 19959317 )
2012
37
The global epidemiology of clonorchiasis and its relation with cholangiocarcinoma. ( 23849183 )
2012
38
A review of the control of clonorchiasis sinensis and Taenia solium taeniasis/cysticercosis in China. ( 23052782 )
2012
39
Clonorchiasis--a historical review of contributions of Japanese parasitologists. ( 21749930 )
2012
40
A combination of the Kato-Katz methods and ELISA to improve the diagnosis of clonorchiasis in an endemic area, China. ( 23056547 )
2012
41
The current status of opisthorchiasis and clonorchiasis in the Mekong Basin. ( 21893213 )
2012
42
Clonorchis sinensis and clonorchiasis, an update. ( 21741496 )
2012
43
Molecular characterization and expression of a cysteine protease from Clonorchis sinensis and its application for serodiagnosis of clonorchiasis. ( 22170263 )
2012
44
Overview of human clonorchiasis sinensis in China. ( 21710843 )
2011
45
Obstructive jaundice caused by Clonorchiasis-associated duodenal papillitis: a case report. ( 21218042 )
2011
46
A case of clonorchiasis with focal intrahepatic duct dilatation mimicking an intrahepatic cholangiocarcinoma. ( 22741114 )
2011
47
Correlation between discharged worms and fecal egg counts in human clonorchiasis. ( 21991401 )
2011
48
Molecular characterization of cathepsin B from Clonorchis sinensis excretory/secretory products and assessment of its potential for serodiagnosis of clonorchiasis. ( 21794140 )
2011
49
Influencing factors for cure of clonorchiasis by praziquantel therapy: infection burden and CYP3A5 gene polymorphism. ( 21461268 )
2011
50
Multiple recombinant antigens of Clonorchis sinensis for serodiagnosis of human clonorchiasis. ( 21125293 )
2011

Variations for Clonorchiasis

Expression for Clonorchiasis

Search GEO for disease gene expression data for Clonorchiasis.

Pathways for Clonorchiasis

Pathways related to Clonorchiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 CD79A CTSF CXCL8 IFNG IL10 IL2
2
Show member pathways
13.54 CXCL8 IFNG IL10 IL2 TGFB1 TNF
3
Show member pathways
13.42 CXCL8 IFNG IL10 IL2 TGFB1 TNF
4
Show member pathways
13.26 CXCL8 IFNG IL10 IL2 TGFB1 TNF
5
Show member pathways
13.19 CXCL8 IL10 IL2 TGFB1 TNF
6
Show member pathways
12.91 CXCL8 IFNG IL10 IL2 TGFB1 TNF
7
Show member pathways
12.77 CXCL8 IFNG IL10 IL2 TGFB1 TNF
8 12.74 CXCL8 IFNG IL2 TGFB1
9
Show member pathways
12.7 CXCL8 IFNG IL2 TNF
10
Show member pathways
12.57 CD79A IFNG IL10 IL2 TNF
11
Show member pathways
12.53 IFNG IL10 IL2 TGFB1 TNF
12
Show member pathways
12.52 IFNG IL10 IL2 TNF
13 12.48 CD79A IFNG IL10 IL2 TNF
14
Show member pathways
12.34 IFNG IL10 IL2 TGFB1 TNF
15
Show member pathways
12.24 IFNG IL2 TNF
16
Show member pathways
12.24 CXCL8 IFNG TNF
17
Show member pathways
12.21 IFNG IL10 TGFB1 TNF
18 12.18 IFNG IL10 TGFB1 TNF
19
Show member pathways
12.14 CXCL8 IFNG IL10 IL2 TGFB1 TNF
20
Show member pathways
12.13 IL10 IL2 TNF
21
Show member pathways
12.11 CXCL8 IFNG TNF
22 12.11 IFNG TGFB1 TNF
23 12.1 CXCL8 IL10 TNF
24
Show member pathways
12.02 CXCL8 IFNG IL10 IL2 TGFB1
25 11.99 IFNG TGFB1 TNF
26
Show member pathways
11.94 IFNG IL10 IL2 TGFB1 TNF
27 11.93 CXCL8 IL10 TGFB1 TNF
28 11.89 CXCL8 IFNG TGFB1
29 11.88 CXCL8 IFNG IL2 TGFB1 TNF
30 11.86 CXCL8 TGFB1 TNF
31 11.83 CXCL8 IL2 TGFB1
32 11.83 CD79A IFNG IL10 IL2 TNF
33 11.82 IFNG IL10 IL2
34 11.8 CXCL8 IFNG TGFB1 TNF
35 11.78 IFNG TGFB1 TNF
36 11.77 CXCL8 IFNG IL2
37 11.73 CXCL8 IL10 TNF
38 11.73 IFNG IL10 IL2 TNF
39 11.7 CXCL8 IFNG IL10 TGFB1 TNF
40
Show member pathways
11.69 CXCL8 IFNG IL2 TNF
41 11.66 IFNG IL2 TGFB1
42 11.64 CXCL8 TGFB1 TNF
43
Show member pathways
11.62 IFNG IL2 TNF
44 11.6 IFNG TGFB1 TNF
45
Show member pathways
11.6 CXCL8 IFNG IL2 TNF
46 11.53 IFNG IL2 TNF
47 11.52 IFNG IL10 IL2 TGFB1 TNF
48 11.51 CXCL8 IL10 TNF
49 11.48 IFNG IL10 IL2
50 11.46 IFNG IL2 TGFB1 TNF

GO Terms for Clonorchiasis

Cellular components related to Clonorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CTSF CXCL8 IFNG IL10 IL2 TGFB1

Biological processes related to Clonorchiasis according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.92 CXCL8 IFNG IL10 IL2 TNF
2 inflammatory response GO:0006954 9.87 CXCL8 IL10 TGFB1 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.81 CXCL8 IL10 TNF
4 cell cycle arrest GO:0007050 9.8 CXCL8 IFNG TGFB1
5 response to organic substance GO:0010033 9.73 IL10 TGFB1 TNF
6 positive regulation of protein phosphorylation GO:0001934 9.73 IFNG IL2 TGFB1 TNF
7 extrinsic apoptotic signaling pathway GO:0097191 9.69 IFNG TGFB1 TNF
8 osteoclast differentiation GO:0030316 9.67 TGFB1 TNF
9 negative regulation of interleukin-6 production GO:0032715 9.66 IL10 TNF
10 positive regulation of cytokine secretion GO:0050715 9.66 IL10 TNF
11 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.65 IL10 TGFB1
12 regulation of synapse organization GO:0050807 9.65 IL10 TNF
13 negative regulation of myoblast differentiation GO:0045662 9.65 TGFB1 TNF
14 leukocyte chemotaxis GO:0030595 9.64 CXCL8 IL10
15 positive regulation of osteoclast differentiation GO:0045672 9.63 IFNG TNF
16 embryonic digestive tract development GO:0048566 9.63 CXCL8 TNF
17 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 IFNG TNF
18 negative regulation of growth of symbiont in host GO:0044130 9.61 IL10 TNF
19 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL10 TNF
20 positive regulation of interleukin-17 production GO:0032740 9.6 IL2 TGFB1
21 negative regulation of interleukin-17 production GO:0032700 9.59 IFNG TGFB1
22 positive regulation of regulatory T cell differentiation GO:0045591 9.58 IL2 TGFB1
23 response to molecule of bacterial origin GO:0002237 9.58 CXCL8 IL10
24 negative regulation of mitotic cell cycle GO:0045930 9.58 IL10 TGFB1 TNF
25 endothelial cell apoptotic process GO:0072577 9.55 IL10 TNF
26 cytokine-mediated signaling pathway GO:0019221 9.55 CXCL8 IL10 IL2 TGFB1 TNF
27 negative regulation of cytokine secretion involved in immune response GO:0002740 9.54 IL10 TNF
28 positive regulation of protein complex assembly GO:0031334 9.5 IFNG TGFB1 TNF
29 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 IFNG TNF
30 positive regulation of mononuclear cell migration GO:0071677 9.48 TGFB1 TNF
31 receptor biosynthetic process GO:0032800 9.46 IL10 TNF
32 protein import into nucleus, translocation GO:0000060 9.43 IFNG TGFB1 TNF
33 positive regulation of vitamin D biosynthetic process GO:0060557 9.37 IFNG TNF
34 regulation of regulatory T cell differentiation GO:0045589 9.13 IFNG IL2 TGFB1
35 regulation of signaling receptor activity GO:0010469 9.1 CXCL8 IFNG IL10 IL2 TGFB1 TNF

Molecular functions related to Clonorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 IL10 IL2 TGFB1
2 cytokine activity GO:0005125 9.1 CXCL8 IFNG IL10 IL2 TGFB1 TNF

Sources for Clonorchiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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