MCID: CLN003
MIFTS: 47

Clonorchiasis

Categories: Infectious diseases, Endocrine diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Clonorchiasis

MalaCards integrated aliases for Clonorchiasis:

Name: Clonorchiasis 12 3 44 15 73
Oriental Liver Fluke Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13767
ICD10 33 B66.1
ICD9CM 35 121.1
MeSH 44 D003003
SNOMED-CT 68 11938002
UMLS 73 C0009021

Summaries for Clonorchiasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Clonorchis sinensis. The symptoms include abdominal pain, nausea, diarrhea, and eosinophilia. In long-standing infections, cholangitis, cholelithiasis, pancreatitis, and cholangiocarcinoma can develop.

MalaCards based summary : Clonorchiasis, also known as oriental liver fluke disease, is related to opisthorchiasis and taeniasis. An important gene associated with Clonorchiasis is CD79A (CD79a Molecule), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include liver, testes and skin, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

CDC : 3  

Wikipedia : 76 Clonorchiasis is an infectious disease caused by the Chinese liver fluke, Clonorchis sinensis, and two... more...

Related Diseases for Clonorchiasis

Diseases related to Clonorchiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 275)
# Related Disease Score Top Affiliating Genes
1 opisthorchiasis 30.6 CTSF CXCL8
2 taeniasis 30.3 CD79A CTSL
3 fascioliasis 30.2 CTSL IFNG IL10
4 obstructive jaundice 30.1 CD79A CXCL8 TNF
5 schistosomiasis 29.3 CD79A IFNG IL10 IL2 TNF
6 lung disease 29.1 CXCL8 IL10 TGFB1 TNF
7 gastrointestinal system disease 28.9 CD79A CXCL8 IFNG IL10 TNF
8 punctate inner choroidopathy 10.8 IL10 TNF
9 tropical endomyocardial fibrosis 10.8 IL10 TNF
10 immunoglobulin a deficiency 1 10.8 CD79A IL10
11 neuroschistosomiasis 10.7 CD79A IFNG
12 microscopic polyangiitis 10.7 IL10 TNF
13 multifocal choroiditis 10.7 IL10 TNF
14 endomyocardial fibrosis 10.7 IL10 TNF
15 transient hypogammaglobulinemia 10.7 IL10 TNF
16 oral tuberculosis 10.7 IL2 TNF
17 cow milk allergy 10.7 CD79A IL10
18 staphylococcal toxic shock syndrome 10.7 IFNG TNF
19 choroiditis 10.7 IL10 TNF
20 idiopathic achalasia 10.7 IL10 TNF
21 hyperlucent lung 10.7 IFNG IL10
22 trichosporonosis 10.7 IFNG TNF
23 mucocutaneous leishmaniasis 10.7 IL10 TNF
24 osteosclerotic myeloma 10.7 CD79A TNF
25 chronic beryllium disease 10.7 IFNG TNF
26 exudative glomerulonephritis 10.7 CD79A CXCL8
27 baylisascariasis 10.6 IFNG IL10
28 variola major 10.6 IFNG IL2
29 trachoma 10.6 IL10 TNF
30 erythema elevatum diutinum 10.6 CD79A CXCL8
31 jejunoileitis 10.6 CD79A TNF
32 pericardial tuberculosis 10.6 IFNG IL10
33 fixed drug eruption 10.6 IFNG IL2
34 berylliosis 10.6 IFNG IL2
35 cervicitis 10.6 CD79A IL2
36 listeriosis 10.6 IL10 TNF
37 acute transverse myelitis 10.6 CXCL8 IL10
38 acute salpingitis 10.6 CD79A TNF
39 soft tissue sarcoma 10.6 IFNG TNF
40 pouchitis 10.6 CXCL8 IL10
41 burning mouth syndrome 10.6 IL2 TNF
42 buruli ulcer 10.6 IFNG IL10
43 cytomegalovirus retinitis 10.6 IFNG TNF
44 scabies 10.5 CXCL8 IL10
45 neurosyphilis 10.5 CXCL8 IL10
46 atopic keratoconjunctivitis 10.5 IFNG IL2
47 necatoriasis 10.5 CXCL8 IL10
48 haemophilus influenzae 10.5 CXCL8 TNF
49 juvenile myasthenia gravis 10.5 IL10 TGFB1
50 vulvovaginitis 10.5 CXCL8 IL10

Graphical network of the top 20 diseases related to Clonorchiasis:



Diseases related to Clonorchiasis

Symptoms & Phenotypes for Clonorchiasis

GenomeRNAi Phenotypes related to Clonorchiasis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 TNF CXCL8 IL10 IL2 TGFB1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 TNF CXCL8 IL10 IL2 TGFB1

MGI Mouse Phenotypes related to Clonorchiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 IL10 IL2 TGFB1 TNF CTSF EPG5
2 hematopoietic system MP:0005397 9.8 IL10 IL2 TGFB1 CD79A TNF EPG5
3 immune system MP:0005387 9.7 IL10 IL2 TGFB1 CD79A TNF EPG5
4 liver/biliary system MP:0005370 9.5 IL2 TGFB1 CD79A TNF EPG5 IFNG
5 neoplasm MP:0002006 9.1 IL2 TGFB1 CD79A TNF IFNG IL10

Drugs & Therapeutics for Clonorchiasis

Search Clinical Trials , NIH Clinical Center for Clonorchiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: clonorchiasis

Genetic Tests for Clonorchiasis

Anatomical Context for Clonorchiasis

MalaCards organs/tissues related to Clonorchiasis:

41
Liver, Testes, Skin, Pancreas, Lung, Bone, Bone Marrow

Publications for Clonorchiasis

Articles related to Clonorchiasis:

(show top 50) (show all 216)
# Title Authors Year
1
Characteristic imaging features of clonorchiasis. ( 29658489 )
2018
2
Clonorchiasis or Paragonimiasis? ( 29483404 )
2018
3
Reply to "Clonorchiasis or Paragonimiasis?" ( 29483405 )
2018
4
Clonorchis sinensis and Clonorchiasis: The Relevance of Exploring Genetic Variation. ( 29753338 )
2018
5
Recombinant adenylate kinase 3 from liver fluke Clonorchis sinensis for histochemical analysis and serodiagnosis of clonorchiasis. ( 29580315 )
2018
6
Clonorchis sinensis omega-class glutathione transferases are reliable biomarkers for serodiagnosis of clonorchiasis and opisthorchiasis. ( 29649604 )
2018
7
Sequence analysis and characterization of pyruvate kinase from Clonorchis sinensis, a 53.1-kDa homopentamer, implicated immune protective efficacy against clonorchiasis. ( 29121987 )
2017
8
Epidemiological and Clinical Parameters Features of Patients with Clonorchiasis in the Geum River Basin, Republic of Korea. ( 28529523 )
2017
9
A new method for estimating the prevalence of clonorchiasis in Korea: A proposal to replace arbitrary riverside sampling. ( 28353615 )
2017
10
Risk mapping of clonorchiasis in the People's Republic of China: A systematic review and Bayesian geostatistical analysis. ( 28253272 )
2017
11
Clonorchiasis Complicated with Diffuse Parenchymal Lung Disease in Children. ( 29176155 )
2017
12
Ultrasonic diagnosis of patients with clonorchiasis and preliminary study of pathogenic mechanism. ( 27393100 )
2016
13
Current status of Clonorchis sinensis and clonorchiasis in China. ( 26740359 )
2016
14
Current status and perspectives of Clonorchis sinensis and clonorchiasis: epidemiology, pathogenesis, omics, prevention and control. ( 27384714 )
2016
15
Advanced Enzymology, Expression Profile and Immune Response of Clonorchis sinensis Hexokinase Show Its Application Potential for Prevention and Control of Clonorchiasis. ( 25799453 )
2015
16
Clonorchiasis. ( 26299184 )
2015
17
Mapping of the putative epitope domain of Clonorchis sinensis paramyosin (CsPmy) recognized by CsPmy-specific immunoglobulin G in sera of human clonorchiasis. ( 26099940 )
2015
18
Identification and characterization of Clonorchis sinensis cathepsin B proteases in the pathogenesis of clonorchiasis. ( 26691339 )
2015
19
In vivo diagnosis of clonorchiasis during cholangioscopy for workup of suspected cholangiocarcinoma (with video). ( 24731267 )
2014
20
Increasing prevalence and intensity of foodborne clonorchiasis, hengxian county, china, 1989-2011. ( 25340976 )
2014
21
Clonorchiasis control: starting from awareness. ( 25243069 )
2014
22
Correlation between clonorchiasis incidences and climatic factors in Guangzhou, China. ( 24428903 )
2014
23
The serological diagnosis of human clonorchiasis by time-resolved fluoroimmunoassay based on GST2-specific IgG4 detection. ( 24169809 )
2014
24
Identification of risk and prognostic factors for patients with clonorchiasis-associated intrahepatic cholangiocarcinoma. ( 24781504 )
2014
25
Control of clonorchiasis in Korea: effectiveness of health education for community leaders and individuals in an endemic area. ( 24862476 )
2014
26
Prevalence and risk factors of clonorchiasis among residents of riverside areas in Muju-gun, Jeollabuk-do, Korea. ( 25246718 )
2014
27
A misdiagnosis of clonorchiasis as gallstone, leading to an unnecessary cholecystectomy: a case report. ( 24881515 )
2014
28
Prevalence and Risk Factors of Clonorchiasis among the Populations Served by Primary Healthcare Posts along Five Major Rivers in South Korea. ( 24159525 )
2013
29
Risk factors for and prevalence of clonorchiasis in Miaoli County, Taiwan. ( 24450231 )
2013
30
Trends in prevalence of clonorchiasis among patients in Heilongjiang province, Northeast China (2009-2012): implications for monitoring and control. ( 24260354 )
2013
31
Time to tackle clonorchiasis in China. ( 23849773 )
2013
32
Serological diagnosis of clonorchiasis: using a recombinant propeptide of cathepsin L proteinase from Clonorchis sinensis as a candidate antigen. ( 22173451 )
2012
33
Oriental cholangiohepatitis (clonorchiasis infestation) caused by Clonorchis sinensis. ( 19959317 )
2012
34
The global epidemiology of clonorchiasis and its relation with cholangiocarcinoma. ( 23849183 )
2012
35
A review of the control of clonorchiasis sinensis and Taenia solium taeniasis/cysticercosis in China. ( 23052782 )
2012
36
Clonorchiasis--a historical review of contributions of Japanese parasitologists. ( 21749930 )
2012
37
A combination of the Kato-Katz methods and ELISA to improve the diagnosis of clonorchiasis in an endemic area, China. ( 23056547 )
2012
38
The current status of opisthorchiasis and clonorchiasis in the Mekong Basin. ( 21893213 )
2012
39
Clonorchis sinensis and clonorchiasis, an update. ( 21741496 )
2012
40
Molecular characterization and expression of a cysteine protease from Clonorchis sinensis and its application for serodiagnosis of clonorchiasis. ( 22170263 )
2012
41
Overview of human clonorchiasis sinensis in China. ( 21710843 )
2011
42
Obstructive jaundice caused by Clonorchiasis-associated duodenal papillitis: a case report. ( 21218042 )
2011
43
A case of clonorchiasis with focal intrahepatic duct dilatation mimicking an intrahepatic cholangiocarcinoma. ( 22741114 )
2011
44
Correlation between discharged worms and fecal egg counts in human clonorchiasis. ( 21991401 )
2011
45
Molecular characterization of cathepsin B from Clonorchis sinensis excretory/secretory products and assessment of its potential for serodiagnosis of clonorchiasis. ( 21794140 )
2011
46
Influencing factors for cure of clonorchiasis by praziquantel therapy: infection burden and CYP3A5 gene polymorphism. ( 21461268 )
2011
47
Multiple recombinant antigens of Clonorchis sinensis for serodiagnosis of human clonorchiasis. ( 21125293 )
2011
48
Hypersensitive reaction to praziquantel in a clonorchiasis patient. ( 22072827 )
2011
49
Effect of control strategies on prevalence, incidence and re-infection of clonorchiasis in endemic areas of China. ( 20169061 )
2010
50
Descriptive epidemiology of cholangiocarcinoma and clonorchiasis in Korea. ( 20592891 )
2010

Variations for Clonorchiasis

Expression for Clonorchiasis

Search GEO for disease gene expression data for Clonorchiasis.

Pathways for Clonorchiasis

Pathways related to Clonorchiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 CD79A CTSF CTSL CXCL8 IFNG IL10
2
Show member pathways
13.54 CXCL8 IFNG IL10 IL2 TGFB1 TNF
3
Show member pathways
13.4 CXCL8 IFNG IL10 IL2 TGFB1 TNF
4
Show member pathways
13.25 CXCL8 IFNG IL10 IL2 TGFB1 TNF
5
Show member pathways
13.18 CXCL8 IL10 IL2 TGFB1 TNF
6
Show member pathways
12.91 CXCL8 IFNG IL10 IL2 TGFB1 TNF
7 12.74 CXCL8 IFNG IL2 TGFB1
8
Show member pathways
12.72 CTSL CXCL8 IFNG IL10 IL2 TGFB1
9
Show member pathways
12.7 CD79A IFNG IL2 TNF
10
Show member pathways
12.69 CXCL8 IFNG IL2 TNF
11
Show member pathways
12.55 CXCL8 IFNG IL10 IL2 TNF
12
Show member pathways
12.52 IFNG IL10 IL2 TNF
13 12.49 CD79A IFNG IL10 IL2 TNF
14
Show member pathways
12.37 IFNG IL10 IL2 TGFB1 TNF
15
Show member pathways
12.34 IFNG IL10 IL2 TGFB1 TNF
16
Show member pathways
12.24 IFNG IL2 TNF
17
Show member pathways
12.24 CXCL8 IFNG TNF
18
Show member pathways
12.21 IFNG IL10 TGFB1 TNF
19 12.2 CTSL TGFB1 TNF
20
Show member pathways
12.18 CXCL8 IFNG TNF
21 12.18 IFNG IL10 TGFB1 TNF
22
Show member pathways
12.15 IFNG IL10 IL2 TGFB1 TNF
23
Show member pathways
12.14 CTSL CXCL8 IFNG TNF
24
Show member pathways
12.13 IL10 IL2 TNF
25 12.1 IFNG TGFB1 TNF
26 12.1 CXCL8 IL10 TNF
27 12.02 CTSL IFNG TNF
28
Show member pathways
12.02 CXCL8 IFNG IL10 IL2 TGFB1
29 11.98 IFNG TGFB1 TNF
30 11.93 CXCL8 IL10 TGFB1 TNF
31 11.89 CXCL8 IFNG TGFB1
32 11.88 CXCL8 IFNG IL2 TGFB1 TNF
33 11.86 CXCL8 TGFB1 TNF
34 11.83 CD79A IFNG IL10 IL2 TNF
35 11.82 IFNG IL10 IL2
36 11.82 CXCL8 IL2 TGFB1
37 11.78 IFNG TGFB1 TNF
38 11.76 CXCL8 IFNG IL2
39 11.73 CXCL8 IL10 TNF
40 11.73 IFNG IL10 IL2 TNF
41 11.7 CXCL8 IFNG IL10 TGFB1 TNF
42
Show member pathways
11.69 CXCL8 IFNG IL2 TNF
43 11.66 IFNG IL2 TGFB1
44 11.63 CXCL8 TGFB1 TNF
45
Show member pathways
11.62 IFNG IL2 TNF
46 11.61 CTSL CXCL8 IFNG TGFB1 TNF
47
Show member pathways
11.6 CXCL8 IFNG IL2 TNF
48 11.59 IFNG TGFB1 TNF
49 11.53 IFNG IL2 TNF
50 11.51 CXCL8 IL10 TNF

GO Terms for Clonorchiasis

Cellular components related to Clonorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CTSL CXCL8 IFNG IL10 IL2 TGFB1
2 extracellular space GO:0005615 9.23 CTSF CTSL CXCL8 IFNG IL10 IL2

Biological processes related to Clonorchiasis according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.92 CXCL8 IFNG IL10 IL2 TNF
2 inflammatory response GO:0006954 9.91 CXCL8 IL10 TGFB1 TNF
3 adaptive immune response GO:0002250 9.84 CD79A CTSL IFNG IL2
4 cell cycle arrest GO:0007050 9.81 CXCL8 IFNG TGFB1
5 cellular response to lipopolysaccharide GO:0071222 9.8 CXCL8 IL10 TNF
6 response to organic substance GO:0010033 9.75 IL10 TGFB1 TNF
7 positive regulation of protein phosphorylation GO:0001934 9.73 IFNG IL2 TGFB1 TNF
8 lipopolysaccharide-mediated signaling pathway GO:0031663 9.66 TGFB1 TNF
9 osteoclast differentiation GO:0030316 9.66 TGFB1 TNF
10 positive regulation of cytokine secretion GO:0050715 9.65 IL10 TNF
11 negative regulation of interleukin-6 production GO:0032715 9.65 IL10 TNF
12 negative regulation of myoblast differentiation GO:0045662 9.65 TGFB1 TNF
13 positive regulation of osteoclast differentiation GO:0045672 9.64 IFNG TNF
14 embryonic digestive tract development GO:0048566 9.64 CXCL8 TNF
15 extrinsic apoptotic signaling pathway GO:0097191 9.63 IFNG TGFB1 TNF
16 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 IFNG TNF
17 negative regulation of growth of symbiont in host GO:0044130 9.62 IL10 TNF
18 response to molecule of bacterial origin GO:0002237 9.61 CXCL8 IL10
19 positive regulation of interleukin-17 production GO:0032740 9.6 IL2 TGFB1
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.59 IL10 TNF
21 negative regulation of interleukin-17 production GO:0032700 9.58 IFNG TGFB1
22 negative regulation of mitotic cell cycle GO:0045930 9.58 IL10 TGFB1 TNF
23 positive regulation of regulatory T cell differentiation GO:0045591 9.57 IL2 TGFB1
24 endothelial cell apoptotic process GO:0072577 9.56 IL10 TNF
25 negative regulation of cytokine secretion involved in immune response GO:0002740 9.55 IL10 TNF
26 cytokine-mediated signaling pathway GO:0019221 9.55 CXCL8 IL10 IL2 TGFB1 TNF
27 receptor biosynthetic process GO:0032800 9.51 IL10 TNF
28 protein import into nucleus, translocation GO:0000060 9.5 IFNG TGFB1 TNF
29 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 IFNG TNF
30 positive regulation of mononuclear cell migration GO:0071677 9.48 TGFB1 TNF
31 positive regulation of protein complex assembly GO:0031334 9.43 IFNG TGFB1 TNF
32 positive regulation of vitamin D biosynthetic process GO:0060557 9.37 IFNG TNF
33 regulation of regulatory T cell differentiation GO:0045589 9.13 IFNG IL2 TGFB1
34 regulation of signaling receptor activity GO:0010469 9.1 CXCL8 IFNG IL10 IL2 TGFB1 TNF

Molecular functions related to Clonorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 IL10 IL2 TGFB1
2 cytokine activity GO:0005125 9.1 CXCL8 IFNG IL10 IL2 TGFB1 TNF

Sources for Clonorchiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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