MCID: CLN003
MIFTS: 42

Clonorchiasis

Categories: Cancer diseases, Gastrointestinal diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Clonorchiasis

MalaCards integrated aliases for Clonorchiasis:

Name: Clonorchiasis 12 3 44 15 17 70 32
Oriental Liver Fluke Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13767
ICD9CM 34 121.1
MeSH 44 D003003
SNOMED-CT 67 11938002
ICD10 32 B66.1
UMLS 70 C0009021

Summaries for Clonorchiasis

CDC : 3 Clonorchis is a liver fluke parasite that humans can get by eating raw or undercooked fish, crabs, or crayfish from areas where the parasite is found. Found across parts of Asia, Clonorchis is also known as the Chinese or oriental liver fluke. Liver flukes infect the liver, gallbladder, and bile duct in humans. While most infected persons do not show any symptoms, infections that last a long time can result in severe symptoms and serious illness. Untreated, infections may persist for up to 25–30 years, the lifespan of the parasite. Diagnosis of Clonorchis infection is based on microscopic identification of the parasite's eggs in stool specimens. Safe and effective medication is available to treat Clonorchis infections. Adequately freezing or cooking fish will kill the parasite.

MalaCards based summary : Clonorchiasis, also known as oriental liver fluke disease, is related to cholangitis and opisthorchiasis. An important gene associated with Clonorchiasis is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include liver, skin and pancreas, and related phenotypes are liver/biliary system and neoplasm

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Clonorchis sinensis. The symptoms include abdominal pain, nausea, diarrhea, and eosinophilia. In long-standing infections, cholangitis, cholelithiasis, pancreatitis, and cholangiocarcinoma can develop.

Wikipedia : 73 Clonorchiasis is an infectious disease caused by the Chinese liver fluke (Clonorchis sinensis) and two... more...

Related Diseases for Clonorchiasis

Diseases related to Clonorchiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 470)
# Related Disease Score Top Affiliating Genes
1 cholangitis 30.8 TNF IL2 IL10 CXCL8
2 opisthorchiasis 30.6 TNF GRN CXCL8 CTSF
3 obstructive jaundice 30.6 TNF IL2 CXCL8
4 schistosomiasis 30.5 TNF IL2 IL10 IGHE IFNG
5 hypereosinophilic syndrome 30.3 IL2 IGHE IFNG CXCL8
6 cysticercosis 30.2 MT-CO1 IL10 IGHE CTSL
7 exanthem 30.1 TNF IL2 IL10 IFNG CXCL8
8 paragonimiasis 30.1 PRSS16 MT-CO1 IGHE CTSL
9 atrophic gastritis 30.0 TNF IL10 CXCL8
10 echinococcosis 30.0 TNF MT-CO1 IL10 IFNG
11 intestinal schistosomiasis 30.0 TNF MT-CO1 IL2 IL10
12 amebiasis 30.0 TNF IL10 CXCL8 CD79A
13 pulmonary tuberculosis 30.0 TNF IL2 IL10 IFNG
14 cystic echinococcosis 29.9 MT-CO1 IL10 IFNG
15 urticaria 29.9 TNF IL10 IGHE CXCL8
16 disease by infectious agent 29.9 TNF IL2 IL10 IFNG
17 parasitic helminthiasis infectious disease 29.8 TNF MT-CO1 IL2 IL10 CTSL
18 toxoplasmosis 29.8 TNF TGFB1 IL10 IFNG CD79A
19 ancylostomiasis 29.8 PRSS16 MT-CO1
20 lung disease 29.8 TNF TGFB1 IL10 IFNG CXCL8
21 acute pancreatitis 29.8 TNF IL10 CXCL8 CTSB
22 sparganosis 29.7 PRSS16 MT-CO1 CTSL
23 taeniasis 29.7 TNF MT-CO1 IL2 IL10 CTSL
24 liver cirrhosis 29.5 TNF TGFB1 IL2 IL10 IFNG CXCL8
25 fascioliasis 29.3 MT-CO1 IL10 IFNG GRN CTSL CTSF
26 cholangiocarcinoma 10.6
27 intrahepatic cholangiocarcinoma 10.6
28 punctate inner choroidopathy 10.4 TNF IL10
29 beryllium disease 10.4 TNF TGFB1
30 tropical endomyocardial fibrosis 10.4 TNF IL10
31 juvenile myasthenia gravis 10.4 TGFB1 IL10
32 multifocal choroiditis 10.4 TNF IL10
33 autoimmune myocarditis 10.4 TNF IFNG
34 palladium allergic contact dermatitis 10.4 TNF IL10
35 polyarticular juvenile idiopathic arthritis 10.4 TNF IFNG
36 idiopathic anterior uveitis 10.4 TNF CXCL8
37 chromium allergic contact dermatitis 10.4 IL2 IL10
38 skeletal tuberculosis 10.4 TNF IFNG
39 acute transverse myelitis 10.4 IL10 CXCL8
40 pericardial tuberculosis 10.4 IL10 IFNG
41 fixed drug eruption 10.4 IL2 IFNG
42 exercise-induced anaphylaxis 10.4 IGHE CD79A
43 acute cervicitis 10.4 IL10 CXCL8
44 acute gonococcal cervicitis 10.4 IL10 CXCL8
45 tertiary syphilis 10.4 TNF IL10
46 immunoglobulin g deficiency 10.4 IGHE CD79A
47 opportunistic bacterial infectious disease 10.4 TNF IFNG
48 neurosyphilis 10.3 IL10 CXCL8
49 leukoregulin 10.3 TGFB1 CXCL8
50 nocardiosis 10.3 TNF IFNG

Graphical network of the top 20 diseases related to Clonorchiasis:



Diseases related to Clonorchiasis

Symptoms & Phenotypes for Clonorchiasis

MGI Mouse Phenotypes related to Clonorchiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.5 CD79A GRN IFNG IL10 IL2 TGFB1
2 neoplasm MP:0002006 9.17 CD79A CTSB IFNG IL10 IL2 TGFB1

Drugs & Therapeutics for Clonorchiasis

Search Clinical Trials , NIH Clinical Center for Clonorchiasis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Albendazole
Praziquantel

Cochrane evidence based reviews: clonorchiasis

Genetic Tests for Clonorchiasis

Anatomical Context for Clonorchiasis

MalaCards organs/tissues related to Clonorchiasis:

40
Liver, Skin, Pancreas, Bone Marrow, Spleen, B Cells

Publications for Clonorchiasis

Articles related to Clonorchiasis:

(show top 50) (show all 757)
# Title Authors PMID Year
1
The dynamics of select cellular responses and cytokine expression profiles in mice infected with juvenile Clonorchis sinensis. 61
33548205 2021
2
Epidemiology and determinants of clonorchiasis in school children in southeastern China. 61
33188749 2021
3
An investigation of Human Clonorchiasis prevalence in an Endemic County in Guangxi Zhuang Autonomous Region, China, 2016. 61
33681487 2021
4
High-quality reference genome for Clonorchis sinensis. 61
33677057 2021
5
Foodborne zoonotic parasites of the family Opisthorchiidae. 61
33158552 2021
6
Effectiveness of a community-based integrated strategy to control soil-transmitted helminthiasis and clonorchiasis in the People's Republic of China. 61
32805214 2021
7
Severe hepatobiliary morbidity is associated with Clonorchis sinensis infection: The evidence from a cross-sectional community study. 61
33507969 2021
8
Human microRNAs in host-parasite interaction: a review. 61
33178551 2020
9
Serodiagnostic antigens of Clonorchis sinensis identified and evaluated by high-throughput proteogenomics. 61
33370333 2020
10
The characteristics of CD4+T-helper cell subset differentiation in experimental Clonorchis sinensis-infected FVB mice. 61
33489026 2020
11
Recombinant CsHscB of carcinogenic liver fluke Clonorchis sinensis induces IL-10 production by binding with TLR2. 61
33044969 2020
12
Bile Ductal Transcriptome Identifies Key Pathways and Hub Genes in Clonorchis sinensis-Infected Sprague-Dawley Rats. 61
33202503 2020
13
Evaluation of immune response to Bacillus subtilis spores expressing Clonorchis sinensis serpin3. 61
32404215 2020
14
Recent Progress in the Development of Liver Fluke and Blood Fluke Vaccines. 61
32971734 2020
15
Marked mitochondrial genetic variation in individuals and populations of the carcinogenic liver fluke Clonorchis sinensis. 61
32813714 2020
16
Prevalence and risk factors associated with Clonorchis sinensis infections in rural communities in northern Vietnam. 61
32745095 2020
17
High endemicity of Clonorchis sinensis infection in Binyang County, southern China. 61
32776933 2020
18
High prevalence of Clonorchis sinensis infections and coinfection with hepatitis virus in riverside villages in northeast China. 61
32678224 2020
19
Rapid screening of Clonorchis sinensis infection: Performance of a method based on raw-freshwater fish-eating practice. 61
32007446 2020
20
Intraductal papillary neoplasia of the bile duct (IPNB): case report and literature review. 61
33181817 2020
21
Review of the control of clonorchiasis in Shandong Province, China from 1962 to 2015. 61
32344009 2020
22
Effectiveness of health education in improving knowledge, practice and belief related to clonorchiasis in children. 61
32278640 2020
23
Fungal and Parasitic Infections of the Liver. 61
32389369 2020
24
In vivo and in vitro studies using Clonorchis sinensis adult-derived total protein (CsTP) on cellular function and inflammatory effect in mouse and cell model. 61
32285266 2020
25
Clonorchis sinensis secretory protein CsAg17 vaccine induces immune protection. 61
32334611 2020
26
Amino acids serve as an important energy source for adult flukes of Clonorchis sinensis. 61
32352979 2020
27
Familial assimilation in transmission of raw-freshwater fish-eating practice leading to clonorchiasis. 61
32352962 2020
28
Surveillance of clonorchiasis in China in 2016. 61
31877282 2020
29
Clonorchis sinensis and clonorchiasis. 61
31862466 2020
30
Dopaminergic antagonists inhibit bile chemotaxis of adult Clonorchis sinensis and its egg production. 61
32226018 2020
31
Assessment of control strategies against Clonorchis sinensis infection based on a multi-group dynamic transmission model. 61
32218570 2020
32
Molecular characterization of a Trichinella spiralis elastase-1 and its potential as a diagnostic antigen for trichinellosis. 61
32093735 2020
33
The control of clonorchiasis in Guangdong province, southern China. 61
31672488 2020
34
Perturbations of Metabolomic Profiling of Spleen From Rats Infected With Clonorchis sinensis Determined by LC-MS/MS Method. 61
33134312 2020
35
From awareness to action: NIPD's engagement in the control of food-borne clonorchiasis. 61
32563327 2020
36
[Value of discriminant analysis for screening of clonorchiasis sinensis]. 61
32458613 2020
37
Clonorchiasis in Patients with Biliary and Pancreatic Diseases: Diagnosis and Risk Factors. 61
32185201 2020
38
Identification and Analysis of the Tegument Protein and Excretory-Secretory Products of the Carcinogenic Liver Fluke Clonorchis sinensis. 61
33072014 2020
39
Partial Characterization of Two Cathepsin D Family Aspartic Peptidases of Clonorchis sinensis. 61
31914521 2019
40
Development of an Immunochromatographic Point-of-Care Test for Serodiagnosis of Opisthorchiasis and Clonorchiasis. 61
31482789 2019
41
Acute shock caused by Clonorchis sinensis infection: a case report. 61
31783809 2019
42
Neglected tropical diseases in the People's Republic of China: progress towards elimination. 61
31578147 2019
43
[Investigation of epidemic status of clonorchiasis sinensis in western regions of Jilin Province]. 61
32468799 2019
44
Cytokine Production in Cholangiocarcinoma Cells in Response to Clonorchis sinensis Excretory-Secretory Products and Their Putative Protein Components. 61
31533404 2019
45
Harmful Parasitoses on the Russian Southern Far East under Climatic and Demographic Changes. 61
31571077 2019
46
Improving diagnostic performance of the Kato-Katz method for Clonorchis sinensis infection through multiple samples. 61
31287026 2019
47
Progress on the development of rapid diagnostic tests for foodborne neglected zoonotic helminthiases: A systematic review. 61
30946810 2019
48
A Clonorchiasis Case of a Leopard Cat, Prionailurus bengalensis euptilurus, Diagnosed by Ultrasonography and Egg Detection in Republic of Korea. 61
31284354 2019
49
[Clinical value of transient elastography (FibroScan) in detection of clonorchiasis]. 61
31544417 2019
50
[Investigation on capacity of provincial parasitic diseases control institutions in main clonorchiasis-endemic areas of China]. 61
31184056 2019

Variations for Clonorchiasis

Expression for Clonorchiasis

Search GEO for disease gene expression data for Clonorchiasis.

Pathways for Clonorchiasis

Pathways related to Clonorchiasis according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 TNF TGFB1 IL2 IL10 IGHE IFNG
2
Show member pathways
13.31 TNF TGFB1 IL2 IL10 IGHE IFNG
3
Show member pathways
13.16 TNF TGFB1 IL2 IL10 IFNG CXCL8
4
Show member pathways
12.6 TNF TGFB1 IL2 IL10 IFNG CXCL8
5
Show member pathways
12.59 TNF IL2 IL10 IGHE IFNG CD79A
6
Show member pathways
12.57 TNF TGFB1 IL2 IL10 IFNG
7
Show member pathways
12.56 TNF TGFB1 IL2 IL10 IFNG
8 12.52 TNF IL2 IL10 IFNG CD79A
9
Show member pathways
12.3 TNF IL2 IL10 CXCL8
10
Show member pathways
12.23 TNF TGFB1 IL10 IFNG
11
Show member pathways
12.21 TNF TGFB1 IL2 IL10 IFNG CXCL8
12 12.2 TNF TGFB1 IL10 IFNG
13
Show member pathways
12.15 TNF IFNG CXCL8 CTSL CTSB
14 12.05 TNF IL2 IL10 CXCL8
15 11.97 TNF TGFB1 IL2 IFNG CXCL8
16 11.94 TNF IL2 IL10 IFNG CD79A
17 11.91 TNF TGFB1 IL10 IGHE CXCL8
18 11.9 TGFB1 IFNG CXCL8
19 11.89 CTSL CTSF CTSB
20 11.87 TNF TGFB1 CXCL8
21 11.84 TNF TGFB1 IFNG
22 11.84 TNF TGFB1 IL10 IFNG CXCL8
23 11.83 TGFB1 IL2 CXCL8
24 11.78 TNF IL2 IL10 IFNG
25 11.77 IL2 IFNG CXCL8
26 11.77 TNF TGFB1 IFNG CXCL8 CTSL
27
Show member pathways
11.75 TNF IL2 IFNG CXCL8
28 11.74 TNF IL10 CXCL8
29 11.67 TGFB1 IL2 IFNG
30 11.67 TNF TGFB1 IL10
31
Show member pathways
11.65 TNF IL2 IFNG CXCL8
32
Show member pathways
11.65 TNF TGFB1 IL2 IL10 IFNG
33 11.64 TNF TGFB1 CXCL8
34
Show member pathways
11.62 TNF IL2 IFNG
35 11.59 TNF TGFB1 IFNG
36 11.59 TNF TGFB1 IL2 IL10 IFNG
37 11.53 TNF IL2 IFNG
38 11.5 TNF IL10 CXCL8
39 11.49 TNF TGFB1 IL2 IFNG
40 11.47 IL2 IL10 IFNG
41 11.36 TNF IL10 IFNG
42 11.25 TNF TGFB1 IL10 IFNG CXCL8
43 11.22 TGFB1 IL2 IFNG
44 11.18 IL2 IL10 IFNG
45 10.99 TNF TGFB1 IL2 IL10 CXCL8
46
Show member pathways
10.91 TNF TGFB1 IL2 IL10 IFNG
47 10.84 TNF TGFB1
48 10.48 TNF TGFB1 IL2 IL10 IFNG

GO Terms for Clonorchiasis

Cellular components related to Clonorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TNF TGFB1 R3HDML IL2 IL10 IGHE
2 lysosome GO:0005764 9.65 PRSS16 GRN CTSL CTSF CTSB
3 extracellular space GO:0005615 9.36 TNF TGFB1 R3HDML IL2 IL10 IFNG
4 endolysosome lumen GO:0036021 9.16 CTSL CTSB

Biological processes related to Clonorchiasis according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.97 IL2 IGHE IFNG CTSL CD79A
2 negative regulation of gene expression GO:0010629 9.94 TNF TGFB1 IFNG CXCL8
3 positive regulation of protein phosphorylation GO:0001934 9.86 TNF TGFB1 IL2 IFNG
4 positive regulation of inflammatory response GO:0050729 9.8 TNF IL2 IFNG
5 response to organic substance GO:0010033 9.79 TNF TGFB1 IL10
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.76 TNF IL2 IFNG
7 positive regulation of protein complex assembly GO:0031334 9.7 TNF TGFB1 IFNG
8 positive regulation of cytokine production GO:0001819 9.69 TNF IL10 IFNG
9 proteolysis involved in cellular protein catabolic process GO:0051603 9.67 CTSL CTSF CTSB
10 extrinsic apoptotic signaling pathway GO:0097191 9.65 TNF TGFB1 IFNG
11 cellular response to thyroid hormone stimulus GO:0097067 9.64 CTSL CTSB
12 positive regulation of signaling receptor activity GO:2000273 9.63 IL10 IFNG
13 positive regulation of regulatory T cell differentiation GO:0045591 9.63 TGFB1 IL2
14 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.63 TNF TGFB1 IL10
15 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.61 TNF TGFB1
16 negative regulation of amyloid-beta clearance GO:1900222 9.61 TNF IFNG
17 negative regulation of mitotic cell cycle GO:0045930 9.61 TNF TGFB1 IL10
18 positive regulation of MHC class II biosynthetic process GO:0045348 9.6 IL10 IFNG
19 response to molecule of bacterial origin GO:0002237 9.59 IL10 CXCL8
20 endothelial cell apoptotic process GO:0072577 9.58 TNF IL10
21 positive regulation of mononuclear cell migration GO:0071677 9.55 TNF TGFB1
22 negative regulation of cytokine production involved in immune response GO:0002719 9.54 TNF IL10
23 cytokine-mediated signaling pathway GO:0019221 9.43 TNF TGFB1 IL2 IL10 IGHE CXCL8
24 positive regulation of plasma cell differentiation GO:1900100 9.4 IL2 IL10
25 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 TNF IFNG
26 regulation of regulatory T cell differentiation GO:0045589 9.33 TGFB1 IL2 IFNG
27 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 TNF IFNG
28 positive regulation of nitrogen compound metabolic process GO:0051173 9.26 TNF IFNG
29 immune response GO:0006955 9.17 TNF IL2 IL10 IGHE IFNG CXCL8

Molecular functions related to Clonorchiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cysteine-type endopeptidase activity GO:0004197 9.33 CTSL CTSF CTSB
2 proteoglycan binding GO:0043394 9.26 CTSL CTSB
3 growth factor activity GO:0008083 9.26 TGFB1 IL2 IL10 GRN
4 cytokine activity GO:0005125 9.17 TNF TGFB1 IL2 IL10 IFNG GRN

Sources for Clonorchiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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