MCID: CLS016
MIFTS: 47

Clostridium Difficile Colitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Clostridium Difficile Colitis

MalaCards integrated aliases for Clostridium Difficile Colitis:

Name: Clostridium Difficile Colitis 12 55 15 73
Pseudomembranous Colitis 12 73
Enterocolitis, Pseudomembranous 44
Clostridium Difficile Infection 73
Colitis Pseudomembranous 55

Classifications:



Summaries for Clostridium Difficile Colitis

Disease Ontology : 12 A colitis characterized by an overgrowth of Clostridium difficile bacteria.

MalaCards based summary : Clostridium Difficile Colitis, also known as pseudomembranous colitis, is related to toxic megacolon and chemical colitis, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Clostridium Difficile Colitis is IL1B (Interleukin 1 Beta), and among its related pathways/superpathways are Prolactin Signaling Pathway and Signaling by Slit. The drugs Vancomycin and Ceftazidime have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and skin.

Related Diseases for Clostridium Difficile Colitis

Diseases related to Clostridium Difficile Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 toxic megacolon 31.3 ATP12A ATP4A
2 chemical colitis 11.4
3 perinatal necrotizing enterocolitis 11.2
4 colitis 10.9
5 haemophilus influenzae 10.7 IL1B LTF
6 fungal esophagitis 10.5 ATP12A ATP4A
7 bladder calculus 10.5 ATP12A ATP4A
8 gastrointestinal neuroendocrine benign tumor 10.5 ATP12A ATP4A
9 neonatal candidiasis 10.5 ATP12A ATP4A
10 photoallergic dermatitis 10.5 ATP12A ATP4A
11 squamous papillomatosis 10.5 ATP12A ATP4A
12 acute laryngitis 10.5 ATP12A ATP4A
13 gastroduodenal crohn's disease 10.5 ATP12A ATP4A
14 gastric neuroendocrine neoplasm 10.4 ATP12A ATP4A
15 aspiration pneumonitis 10.4 ATP12A ATP4A
16 postsurgical hypothyroidism 10.4 ATP12A ATP4A
17 gastric antral vascular ectasia 10.4 ATP12A ATP4A
18 esophageal candidiasis 10.4 ATP12A ATP4A
19 duodenitis 10.4 ATP12A ATP4A
20 erdheim-chester disease 10.4 CCR6 IL1B
21 rumination disorder 10.4 ATP12A ATP4A
22 bile reflux 10.4 ATP12A ATP4A
23 granulomatous gastritis 10.4 ATP12A ATP4A
24 active peptic ulcer disease 10.4 ATP12A ATP4A
25 laryngeal disease 10.4 ATP12A ATP4A
26 ischemic neuropathy 10.4 ATP12A ATP4A
27 capillary disease 10.4 ATP12A ATP4A
28 duodenal disease 10.4 ATP12A ATP4A
29 dyskinesia of esophagus 10.4 ATP12A ATP4A
30 megacolon 10.4
31 hernia, hiatus 10.4 ATP12A ATP4A
32 congenital disorder of deglycosylation 10.4 ATP12A ATP4A
33 anismus 10.4 ATP12A ATP4A
34 esophageal atresia/tracheoesophageal fistula 10.4 ATP12A ATP4A
35 laryngeal tuberculosis 10.4 ATP12A ATP4A
36 lymphocytic colitis 10.4 ATP12A ATP4A
37 lower urinary tract calculus 10.4 ATP12A ATP4A
38 aspiration pneumonia 10.3 ATP12A ATP4A
39 diarrhea 1, secretory chloride, congenital 10.3 ATP12A ATP4A
40 chronic laryngitis 10.3 ATP12A ATP4A
41 chronic intestinal vascular insufficiency 10.3 ATP12A ATP4A
42 eosinophilic gastritis 10.3 ATP12A ATP4A
43 polyposis, skin pigmentation, alopecia, and fingernail changes 10.3 ATP12A ATP4A
44 esophageal varix 10.3 ATP12A ATP4A
45 esophagus adenocarcinoma 10.3 ATP12A ATP4A
46 myopathy, x-linked, with excessive autophagy 10.3 ATP12A ATP4A
47 keratoconjunctivitis sicca 10.3 IL1B LTF
48 gastric lymphoma 10.3 ATP12A ATP4A
49 pancreatic steatorrhea 10.3 ATP12A ATP4A
50 arthritis 10.2

Graphical network of the top 20 diseases related to Clostridium Difficile Colitis:



Diseases related to Clostridium Difficile Colitis

Symptoms & Phenotypes for Clostridium Difficile Colitis

UMLS symptoms related to Clostridium Difficile Colitis:


abdominal pain, constipation, diarrhea, dyspepsia, fever, heartburn, icterus, nausea and vomiting, pruritus, gastrointestinal gas

Drugs & Therapeutics for Clostridium Difficile Colitis

Drugs for Clostridium Difficile Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 176)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vancomycin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1404-90-6 441141 14969
2
Ceftazidime Approved Phase 4,Phase 2,Phase 3 78439-06-2, 72558-82-8 5481173
3
Meropenem Approved, Investigational Phase 4 119478-56-7 64778 441130
4
Piperacillin Approved Phase 4 66258-76-2 43672
5
Tazobactam Approved Phase 4 89786-04-9 123630
6
Ciprofloxacin Approved, Investigational Phase 4,Not Applicable 85721-33-1 2764
7
Cilastatin Approved, Investigational Phase 4 82009-34-5 5280454 6435415
8
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
9
Rifaximin Approved, Investigational Phase 4 80621-81-4 6436173
10
Pantoprazole Approved Phase 4,Phase 3,Not Applicable 102625-70-7 4679
11
Cefazolin Approved Phase 4,Phase 2,Phase 3,Not Applicable 25953-19-9 656510 33255
12
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
13
Fosfomycin Approved Phase 4 23155-02-4 446987
14
Sulfamethoxazole Approved Phase 4,Not Applicable 723-46-6 5329
15
Trimethoprim Approved, Vet_approved Phase 4,Not Applicable 738-70-5 5578
16
Metronidazole Approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 443-48-1 4173
17
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
18
Ceftriaxone Approved Phase 4,Phase 3,Phase 2 73384-59-5 5479530 5361919
19
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
20
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
21
Pancrelipase Approved, Investigational Phase 4 53608-75-6
22
Iron Approved Phase 4 7439-89-6 23925
23 Titanium dioxide Approved Phase 4 13463-67-7
24
Loperamide Approved Phase 4,Phase 2,Phase 3 53179-11-6 3955
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 59-30-3 6037
26
leucovorin Approved, Nutraceutical Phase 4,Not Applicable 58-05-9 143 6006
27 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
28 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
29 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Cathartics Phase 4,Phase 2,Phase 3
31 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Laxatives Phase 4,Phase 2,Phase 3
33 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Polyethylene glycol 3350 Phase 4,Phase 2,Phase 3,Not Applicable
35 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
36 beta-Lactamase Inhibitors Phase 4,Phase 3,Phase 2
37 beta-Lactams Phase 4
38 Lactams Phase 4
39 Penicillanic Acid Phase 4
40 penicillins Phase 4,Phase 3,Phase 2,Not Applicable
41 Piperacillin, tazobactam drug combination Phase 4
42 Thienamycins Phase 4
43 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3,Not Applicable
44 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Not Applicable
45 Fluoroquinolones Phase 4,Phase 3,Phase 1
46 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 1,Not Applicable
47 HIV Protease Inhibitors Phase 4
48
protease inhibitors Phase 4
49 Antacids Phase 4,Phase 3,Phase 1,Not Applicable
50 Anti-Ulcer Agents Phase 4,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 258)
# Name Status NCT ID Phase Drugs
1 Vancomycin Prophylaxis in Recurrent Clostridium Difficile Infection Unknown status NCT02237859 Phase 4 Vancomycin
2 Clostridial Infection and Oral Lavage -Improving Treatment Before Illness Becomes Severe Unknown status NCT01630096 Phase 4 Nu-Lytely
3 Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropenia Unknown status NCT02463747 Phase 4 Piperacillin/tazobactam;Ceftazidim;Meropenem;Vancomycin
4 Ciprofloxacin for Prevention of BK Infection Unknown status NCT01789203 Phase 4 Ciprofloxacin;placebo
5 Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO Unknown status NCT02149329 Phase 4 Discontinuation of imipenem-cilastatin or meropenem
6 Oral Vancomyin for Primary Clostridium Difficile Infection Prophylaxis in Patients Receiving High-Risk Antibiotics Completed NCT02951702 Phase 4 Vancomycin Oral
7 Study to Evaluate the Pharmacokinetics of Fidaxomicin in Inflammatory Bowel Disease (IBD) Subjects With Clostridium Difficile Infection (CDI) Completed NCT02437591 Phase 4 fidaxomicin
8 Study to Assess Inhibition of Spore Production in Patients With C. Difficile Infections: Fidaxomicin Versus Vancomycin Completed NCT01818141 Phase 4 Vancomycin;Fidaxomicin
9 A Phase IIIB/IV Study to Compare the Efficacy of Vancomycin Therapy to Extended Duration of Fidaxomicin Therapy in the Clinical Cure of Clostridium Difficile Infection (CDI) in an Older Population Completed NCT02254967 Phase 4 Fidaxomicin;Vancomycin
10 Rifaximin for Preventing Relapse of Clostridium Associated Diarrhoea Completed NCT01670149 Phase 4 Rifaximin;Placebo
11 Stress Ulcer Prophylaxis in the Intensive Care Unit Completed NCT02467621 Phase 4 Pantoprazole
12 Postoperative Antibiotic Requirements Following Immediate Breast Reconstruction Completed NCT01244698 Phase 4 Cefadroxil discontinued early;Cefadroxil until drain removal
13 Perioperative Fosfomycin in the Prophylaxis of Urinary Tract Infection in Kidney Transplant Recipients Completed NCT03235947 Phase 4 Fosfomycin disodium;Trimethoprim / Sulfamethoxazole;Intravenous placebo
14 Screening to Prophylax Against Clostridium Difficile Infection - Recruiting NCT02996487 Phase 4 Vancomycin
15 Oral Vancomycin for Preventing Clostridium Difficile Recurrence Recruiting NCT03200093 Phase 4 Oral Vancomycin;Placebo
16 A Comparison of Fidaxomicin and Vancomycin in Patients With CDI Receiving Antibiotics for Concurrent Infections Recruiting NCT02692651 Phase 4 Fidaxomicin;Vancomycin
17 Optimal Treatment for Recurrent Clostridium Difficile Recruiting NCT02667418 Phase 4 Fidaxomicin;Vancomycin with Taper/Pulse;Vancomycin
18 C. Difficile and Ursodiol Recruiting NCT02748616 Phase 4 Ursodiol
19 Antibiotics to Decrease Post ERCP Cholangitis Recruiting NCT03087656 Phase 4 Ceftriaxone;Levofloxacin
20 GRam Stain-guided Antibiotics ChoicE for Ventilator-Associated Pneumonia (GRACE-VAP) Trial Recruiting NCT03506113 Phase 4 Gram stain-guided antibiotic choice;Guidelines-based antibiotics choice
21 Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial Recruiting NCT02462590 Phase 4 L. rhamnosus GG - Probiotic;Placebo - Microcrystalline Cellulose
22 Oral Vancomycin to Prevent Recurrent C Difficile Infection With Antibiotics Enrolling by invitation NCT03466502 Phase 4 Oral Vancomycin
23 TOX NEG Trial: Clostridium Difficile Diagnosis and Treatment Enrolling by invitation NCT03388268 Phase 4 Oral Vancomycin;Placebo
24 Fidaxomicin Versus Standard of Care Therapy in Solid Organ Transplant Recipients With Clostridium Difficile Infection Not yet recruiting NCT02464306 Phase 4 fidaxomicin
25 Treatment of Clostridium Difficile in Colonized Patients in the Hematology Oncology Population Not yet recruiting NCT03030248 Phase 4 Vancomycin Oral Capsule;Placebo Oral Capsule
26 Seven Versus Fourteen Days of Treatment in Uncomplicated Staphylococcus Aureus Bacteremia Not yet recruiting NCT03514446 Phase 4 Antibiotic therapy duration for 7 days
27 Efficacy of Loperamide for C. Difficile Colitis and Other Diarrheal Diseases Associated With Antibiotic Therapy Suspended NCT00591357 Phase 4 loperamide;placebo
28 Study of Bio-K+® in the Reduction of the Risk of Clostridium Difficile Infection and Antibiotic Associated Diarrhea Terminated NCT01972932 Phase 4
29 Use Of Oral Fidaxomicin Vs. Oral Vancomycin For Clostridium Difficile Infection In Patients With Spinal Cord Injury Terminated NCT02355938 Phase 4 Fidaxomicin 200 mg;Placebo;Vancomycin
30 A Post-marketing, Blinded Study to Investigate How Effective Fidaxomicin is Compared to Vancomycin in the Sustained Cure of Clostridium Difficile Infection in Adults That Are Receiving Therapy to Suppress the Immune System Terminated NCT01775397 Phase 4 Fidaxomicin;Vancomycin;Placebo
31 Efficacy of Metronidazole Prophylaxis Against Clostridium Difficile-Associated Diarrhea in High Risk Adult Patients Terminated NCT02200328 Phase 4 Metronidazole;Placebo
32 Fidaxomicin to Prevent Clostridium Difficile Colonization Withdrawn NCT01552668 Phase 4 Fidaxomicin;Placebo
33 Addition of Lactobacillus to Metronidazole in Treatment of CDAD Withdrawn NCT00304863 Phase 4 Lactobacillus GG
34 Temocillin Use in Complicated Urinary Tract Infections Due to Extended Spectrum Beta-Lactamases (ESBL)/AmpC Enterobacteriaceae Withdrawn NCT01543347 Phase 4 Temocillin
35 Transplantation of Fecal Microbiota for Clostridium Difficile Infection Unknown status NCT01958463 Phase 3
36 Hospital Design and Risk of Nosocomial Infections: A Prospective Controlled Trial Unknown status NCT00563186 Phase 3
37 Randomized Controlled Trial Comparing Long and Short Duration of Antibiotic Prophylaxis for Patients Undergoing Sinus Lift Surgery Unknown status NCT02764710 Phase 3 Amoxicillin-Potassium Clavulanate Combination
38 A Study of MK-3415, MK-6072, and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-001) Completed NCT01241552 Phase 3 SOC
39 A Study of MK-6072 and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-002) Completed NCT01513239 Phase 3 SOC
40 Compassionate Use of Nitazoxanide for the Treatment of Clostridium Difficile Infection Completed NCT00304356 Phase 3 Nitazoxanide
41 Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile-associated Diarrhea Completed NCT01983683 Phase 3 Cadazolid;Vancomycin;Cadazolid-matching placebo;Vancomycin-matching placebo
42 Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile - Associated Diarrhea Completed NCT01987895 Phase 3 Cadazolid;Vancomycin;Cadazolid-matching placebo;Vancomycin-matching placebo
43 A Study of CB-183,315 in Participants With Clostridium Difficile Associated Diarrhea (MK-4261-006) Completed NCT01598311 Phase 3 CB-183,315;Vancomycin;Placebo
44 Study of CB-183,315 in Participants With Clostridium Difficile Associated Diarrhea (MK-4261-005) Completed NCT01597505 Phase 3 Surotomycin;Vancomycin;Placebo
45 Probiotic Lactobacillus Reuteri to Prevent Antibiotic-associated Diarrhea and Clostridium Difficile-related Infections in Hospitalized Children Completed NCT01295918 Phase 3
46 A Study of GT267-004 Versus Vancomycin and GT267-004 Versus Metronidazole in Patients With C.Difficile - Associated Diarrhea Completed NCT00106509 Phase 3 tolevamer potassium-sodium (GT267-004)
47 Re-Evaluating the Inhibition of Stress Erosions: Gastrointestinal Bleeding Prophylaxis In ICU Completed NCT02290327 Phase 3 Pantoprazole;Placebo
48 Efficacy of Metronidazole Versus Metronidazole and Rifampin in CDAD Treatment Completed NCT00182429 Phase 3 Metronidazole and Rifampin
49 Prospective Randomized Trial of Seminal Vesicle-Sparing Prostatectomy and Nerve-Sparing Radical Prostatectomy in Men With Clinically Localized Prostate Cancer Completed NCT01825642 Phase 2, Phase 3
50 A Study of GT267-004 Versus Vancomycin and GT267-004 Versus Metronidazole in Patients With C. Difficile-Associated Diarrhea Completed NCT00196794 Phase 3 Tolevamer potassium-sodium (GT267-004)

Search NIH Clinical Center for Clostridium Difficile Colitis

Cochrane evidence based reviews: enterocolitis, pseudomembranous

Genetic Tests for Clostridium Difficile Colitis

Anatomical Context for Clostridium Difficile Colitis

MalaCards organs/tissues related to Clostridium Difficile Colitis:

41
Colon, Kidney, Skin, Breast, Prostate, Liver, Spinal Cord

Publications for Clostridium Difficile Colitis

Articles related to Clostridium Difficile Colitis:

(show top 50) (show all 93)
# Title Authors Year
1
How Common-and How Serious- Is Clostridium difficile Colitis After Geriatric Hip Fracture? Findings from the NSQIP Dataset. ( 29443839 )
2018
2
Editor's Spotlight/Take 5: How Common-and How Serious-Is Clostridium difficile Colitis After Geriatric Hip Fracture? Findings from the NSQIP Dataset. ( 29443838 )
2018
3
Frailty Predicts Morbidity and Mortality after Colectomy for Clostridium difficile Colitis. ( 29966560 )
2018
4
A case report of successful management of clostridium difficile colitis with antegrade Fidaxomicin through a mucous fistula obviating the need for subtotal colectomy. ( 29227855 )
2018
5
Reducing Clostridium difficile Colitis Rates Via Cost-Saving Diagnostic Stewardship. ( 29611494 )
2018
6
Prolonged antibiotic use leading to Clostridium difficile colitis in an ill returned traveller with acute fascioliasis. ( 29608740 )
2018
7
Serum-Derived Bovine Immunoglobulin as Novel Adjunct in Complicated Clostridium difficile Colitis Treatment. ( 28516109 )
2017
8
Acute Appendicitis: An Extracolonic Manifestation of Clostridium difficile Colitis. ( 28757875 )
2017
9
Can Procalcitonin Contribute to the Diagnosis of Clostridium difficile Colitis? ( 28513121 )
2017
10
Clostridium difficile colitis: A clinical review. ( 28131326 )
2017
11
Effects of a New Hospital-Wide Surgical Consultation Protocol in Patients with Clostridium difficile Colitis. ( 28557651 )
2017
12
Polyethylene glycol intestinal lavage in addition to usual antibiotic treatment for severe Clostridium difficile colitis: a randomised controlled pilot study. ( 28760801 )
2017
13
Clostridium Difficile, Colitis, and Colonoscopy: Pediatric Perspective. ( 28707191 )
2017
14
Differentiating Clostridium difficile Colitis from Clostridium difficile Colonization in Ulcerative Colitis: A Role for Procalcitonin. ( 29032373 )
2017
15
Protection of Hamsters from Mortality by Reducing Fecal Moxifloxacin Concentration with DAV131A in a Model of Moxifloxacin-Induced Clostridium difficile Colitis. ( 28739791 )
2017
16
Intracolonic Vancomycin Through Laprascopic Appendicostomy for Treatment of Severe Clostridium difficile Colitis Does Not Get Systemic Absorption. ( 28301334 )
2017
17
Incidence, Risk Factors, and Impact of Clostridium difficile Colitis Following Primary Total Hip and Knee Arthroplasty. ( 28870746 )
2017
18
The risk for Clostridium difficile colitis during hospitalization in asymptomatic carriers. ( 28202190 )
2017
19
IVIG - A cure to severe refractory NAP-1 Clostridium difficile colitis? A case of successful treatment of severe infection, which failed standard therapy including fecal microbiota transplants and fidaxomicin. ( 28331803 )
2017
20
Incidence, Risk Factors, and Impact of Clostridium Difficile Colitis After Spine Surgery: An Analysis of a National Database. ( 28953711 )
2017
21
Risk Factors and Costs Associated With Clostridium difficile Colitis in Patients With Prosthetic Joint Infection Undergoing Revision Total Hip Arthroplasty. ( 29273290 )
2017
22
Use of tigecycline for the management of Clostridium difficile colitis in oncology patients and case series of breakthrough infections. ( 28153556 )
2017
23
Successful Therapy of Severe Pseudomembranous Clostridium difficile Colitis using Combination of Fecal Microbiota Therapy and Fidaxomicin. ( 27978522 )
2016
24
Clostridium difficile colitis: pathogenesis and host defence. ( 27573580 )
2016
25
Vesicoileal fistula and Clostridium difficile colitis in a child with acute lymphoblastic leukemia. ( 27842209 )
2016
26
Novel therapies for severe Clostridium difficile colitis. ( 26771898 )
2016
27
A case of reactive arthritis due to Clostridium difficile colitis. ( 26908381 )
2016
28
Identification of Signet Ring Cell Change in Colonic Subserosa in the Setting of Clostridium difficile Colitis: Report of a Nonneoplastic Mimicker of Signet Ring Cell Carcinoma. ( 27562801 )
2016
29
Blastocystis sp. Infection Mimicking Clostridium Difficile Colitis. ( 27247810 )
2016
30
Preclinical development of Ramizol, an antibiotic belonging to a new class, for the treatment of Clostridium difficile colitis. ( 27189122 )
2016
31
Coexisting cytomegalovirus infection in immunocompetent patients with Clostridium difficile colitis. ( 26850320 )
2016
32
The efficacy of intracolonic vancomycin for severe Clostridium difficile colitis: a case series. ( 27388627 )
2016
33
Hospitalized Patients with Cirrhosis Should Be Screened for Clostridium difficile Colitis. ( 25986524 )
2015
34
Acute graft-versus-host disease, invasive aspergillosis and Clostridium difficile colitis after peripheral blood stem cell transplantation: A complex network of causalities and a challenge for prevention. ( 25749258 )
2015
35
Loss of Vancomycin-Resistant Enterococcus Fecal Dominance in an Organ Transplant Patient With Clostridium difficile Colitis After Fecal Microbiota Transplant. ( 26180828 )
2015
36
Antibiotic Regimen after a Total Abdominal Colectomy with Ileostomy for Fulminant Clostridium difficile Colitis: A Multi-Institutional Study. ( 26069992 )
2015
37
Persistent and Recurrent Clostridium difficile Colitis. ( 26034401 )
2015
38
Fecal Microbiota Transplant for Clostridium difficile Colitis-Induced Toxic Megacolon. ( 25942309 )
2015
39
Proton pump inhibitor exposure aggravates Clostridium difficile colitis: evidences from a mouse model. ( 25805751 )
2015
40
IL-23, Independent of IL-17 and IL-22, Drives Neutrophil Recruitment and Innate Inflammation During Clostridium difficile Colitis in Mice. ( 26455347 )
2015
41
A Curiously Rare Case of Septic Shock From Clostridium difficile Colitis. ( 26221790 )
2015
42
Concomitant CMV and Clostridium difficile colitis in an immunocompetent patient treated with Ganciclovir and fecal transplantation. ( 24949617 )
2014
43
Fidaxomicin for Clostridium difficile Colitis in a peritoneal dialysis patient with underlying mitochondriopathy. ( 24525607 )
2014
44
Acute Oxalate Nephropathy Associated With Clostridium difficile Colitis. ( 24183111 )
2014
45
Saccharomyces cerevisiae fungemia, a possible consequence of the treatment of Clostridium difficile colitis with a probioticum. ( 24674691 )
2014
46
Fecal Microbiota Transplantation for Refractory Clostridium difficile Colitis in Solid Organ Transplant Recipients. ( 24433460 )
2014
47
The Role of Gr-1(+) Cells and TNFI+ Signaling During Clostridium difficile Colitis in Mice. ( 25399934 )
2014
48
Life after colectomy for fulminant Clostridium difficile colitis: a 7-year follow up study. ( 24674828 )
2014
49
Clostridium difficile colitis in patients undergoing lumbar spine surgery. ( 24979408 )
2014
50
Fecal Transplant for Treatment of Toxic Megacolon Associated With Clostridium Difficile Colitis in a Patient With Duchenne Muscular Dystrophy. ( 24858336 )
2014

Variations for Clostridium Difficile Colitis

Expression for Clostridium Difficile Colitis

Search GEO for disease gene expression data for Clostridium Difficile Colitis.

Pathways for Clostridium Difficile Colitis

Pathways related to Clostridium Difficile Colitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.78 CDC42 IL1B LEPR
2 10.64 CDC42 CLASP2
3 10.13 IL1B TOX

GO Terms for Clostridium Difficile Colitis

Biological processes related to Clostridium Difficile Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 establishment or maintenance of cell polarity GO:0007163 9.46 CDC42 CLASP2
2 potassium ion import GO:0010107 9.43 ATP12A ATP4A
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.43 IL1B LTF PSMA6
4 positive regulation of epithelial cell migration GO:0010634 9.4 CCR6 CLASP2
5 ATP hydrolysis coupled proton transport GO:0015991 9.37 ATP12A ATP4A
6 cellular sodium ion homeostasis GO:0006883 9.32 ATP12A ATP4A
7 cellular potassium ion homeostasis GO:0030007 9.16 ATP12A ATP4A
8 sodium ion export across plasma membrane GO:0036376 8.96 ATP12A ATP4A
9 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP12A ATP4A

Molecular functions related to Clostridium Difficile Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Clostridium Difficile Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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