MCID: CLS016
MIFTS: 50

Clostridium Difficile Colitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Clostridium Difficile Colitis

MalaCards integrated aliases for Clostridium Difficile Colitis:

Name: Clostridium Difficile Colitis 12 55 15 73
Pseudomembranous Colitis 12 73
Enterocolitis, Pseudomembranous 44
Clostridium Difficile Infection 73
Colitis Pseudomembranous 55

Classifications:



External Ids:

Disease Ontology 12 DOID:0060185
ICD10 33 A04.7
MeSH 44 D004761
NCIt 50 C128347
SNOMED-CT 68 51180003

Summaries for Clostridium Difficile Colitis

CDC : 3 People getting medical care can catch serious infections called healthcare-associated infections (HAIs). One type of HAI – caused by the germ C. difficile – was estimated to cause almost half a million infections in the United States in 2011, and 29,000 died within 30 days of the initial diagnosis. Those most at risk are people, especially older adults, who take antibiotics and also get medical care. CDC provides guidelines and tools to the healthcare community to help prevent Clostridium difficile infections as well as provides resources to help the public safeguard their own health.

MalaCards based summary : Clostridium Difficile Colitis, also known as pseudomembranous colitis, is related to toxic megacolon and gastrointestinal system disease, and has symptoms including nausea and vomiting, constipation and fever. An important gene associated with Clostridium Difficile Colitis is LTF (Lactotransferrin), and among its related pathways/superpathways are Prolactin Signaling Pathway and Defensins. The drugs Vancomycin and Meropenem have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and lung.

Disease Ontology : 12 A colitis characterized by an overgrowth of Clostridium difficile bacteria.

Wikipedia : 76 Clostridioides difficile infection (CDI or C-diff), also known as Clostridium difficile infection, is a... more...

Related Diseases for Clostridium Difficile Colitis

Diseases related to Clostridium Difficile Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)
# Related Disease Score Top Affiliating Genes
1 toxic megacolon 31.0 ATP12A ATP4A
2 gastrointestinal system disease 29.7 ATP12A ATP4A IL1B LTF
3 chemical colitis 11.6
4 colitis 11.3
5 megacolon 10.5
6 diarrhea 10.5
7 cystic fibrosis 10.4
8 arthritis 10.4
9 ulcerative colitis 10.3
10 reactive arthritis 10.3
11 hemolytic-uremic syndrome 10.3
12 haemophilus influenzae 10.2 IL1B LTF
13 intussusception 10.2
14 enterocolitis 10.2
15 leukemia 10.2
16 spinal cord injury 10.2
17 infant botulism 10.2
18 lymphoma 10.2
19 ischemic colitis 10.2
20 pneumonia 10.2
21 peritonitis 10.2
22 appendicitis 10.2
23 cytomegalovirus infection 10.2
24 peptic ulcer disease 10.2 ATP4A IL1B
25 fungal esophagitis 10.1 ATP12A ATP4A
26 diclofenac allergy 10.1 ATP12A ATP4A
27 gastroduodenal crohn's disease 10.1 ATP12A ATP4A
28 neonatal candidiasis 10.1 ATP12A ATP4A
29 photoallergic dermatitis 10.1 ATP12A ATP4A
30 squamous papillomatosis 10.1 ATP12A ATP4A
31 aspiration pneumonitis 10.1 ATP12A ATP4A
32 gastrointestinal neuroendocrine benign tumor 10.1 ATP12A ATP4A
33 gastric antral vascular ectasia 10.1 ATP12A ATP4A
34 granulomatous gastritis 10.1 ATP12A ATP4A
35 esophageal candidiasis 10.1 ATP12A ATP4A
36 gastric neuroendocrine neoplasm 10.1 ATP12A ATP4A
37 acute laryngitis 10.1 ATP12A ATP4A
38 duodenitis 10.1 ATP12A ATP4A
39 rumination disorder 10.1 ATP12A ATP4A
40 active peptic ulcer disease 10.1 ATP12A ATP4A
41 aseptic meningitis 10.1 IL1B LTF
42 congenital disorder of deglycosylation 10.1 ATP12A ATP4A
43 bladder calculus 10.1 ATP12A ATP4A
44 ischemic neuropathy 10.1 ATP12A ATP4A
45 bile reflux 10.1 ATP12A ATP4A
46 capillary disease 10.1 ATP12A ATP4A
47 dyskinesia of esophagus 10.1 ATP12A ATP4A
48 hernia, hiatus 10.1 ATP12A ATP4A
49 anismus 10.1 ATP12A ATP4A
50 postsurgical hypothyroidism 10.1 ATP12A ATP4A

Graphical network of the top 20 diseases related to Clostridium Difficile Colitis:



Diseases related to Clostridium Difficile Colitis

Symptoms & Phenotypes for Clostridium Difficile Colitis

UMLS symptoms related to Clostridium Difficile Colitis:


nausea and vomiting, constipation, fever, abdominal pain, pruritus, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas

Drugs & Therapeutics for Clostridium Difficile Colitis

Drugs for Clostridium Difficile Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 182)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vancomycin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1404-90-6 14969 441141
2
Meropenem Approved, Investigational Phase 4 119478-56-7 64778 441130
3
Tazobactam Approved Phase 4 89786-04-9 123630
4
Piperacillin Approved Phase 4 66258-76-2 43672
5
Ceftazidime Approved Phase 4,Phase 2,Phase 3 78439-06-2, 72558-82-8 5481173
6
Ciprofloxacin Approved, Investigational Phase 4,Not Applicable 85721-33-1 2764
7
Cilastatin Approved, Investigational Phase 4 82009-34-5 6435415 5280454
8
Imipenem Approved Phase 4 74431-23-5, 64221-86-9 104838
9
Rifaximin Approved, Investigational Phase 4,Phase 2,Phase 3 80621-81-4 6436173
10
Pantoprazole Approved Phase 4,Phase 3,Not Applicable 102625-70-7 4679
11
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
12
Cefazolin Approved Phase 4,Phase 2,Phase 3,Not Applicable 25953-19-9 656510 33255
13
Sulfamethoxazole Approved Phase 4,Not Applicable 723-46-6 5329
14
leucovorin Approved Phase 4,Not Applicable 58-05-9 6006 143
15
Fosfomycin Approved Phase 4 23155-02-4 446987
16
Trimethoprim Approved, Vet_approved Phase 4,Not Applicable 738-70-5 5578
17
Metronidazole Approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 443-48-1 4173
18
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
19
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
20
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
21
Ceftriaxone Approved Phase 4,Phase 3,Phase 2 73384-59-5 5479530 5361919
22
Iron Approved Phase 4 7439-89-6 23925
23
Titanium dioxide Approved Phase 4 13463-67-7
24
Loperamide Approved Phase 4,Phase 2,Phase 3 53179-11-6 3955
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 59-30-3 6037
26 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
27 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
28 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
29 Laxatives Phase 4,Phase 2,Phase 3,Not Applicable
30 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Cathartics Phase 4,Phase 2,Phase 3,Not Applicable
33 Polyethylene glycol 3350 Phase 4,Phase 2,Phase 3,Not Applicable
34 penicillins Phase 4,Phase 3,Phase 2,Not Applicable
35 beta-Lactamase Inhibitors Phase 4,Phase 3,Phase 2
36 Penicillanic Acid Phase 4
37 Piperacillin, tazobactam drug combination Phase 4
38 Antitubercular Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
39 beta-Lactams Phase 4
40 Lactams Phase 4
41 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Not Applicable
42 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3,Not Applicable
43 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 1,Not Applicable
44 Fluoroquinolones Phase 4,Phase 3,Phase 1,Not Applicable
45 HIV Protease Inhibitors Phase 4
46
protease inhibitors Phase 4
47 Thienamycins Phase 4
48 Anti-Ulcer Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Antacids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Proton Pump Inhibitors Phase 4,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 286)
# Name Status NCT ID Phase Drugs
1 Vancomycin Prophylaxis in Recurrent Clostridium Difficile Infection Unknown status NCT02237859 Phase 4 Vancomycin
2 Clostridial Infection and Oral Lavage -Improving Treatment Before Illness Becomes Severe Unknown status NCT01630096 Phase 4 Nu-Lytely
3 Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropenia Unknown status NCT02463747 Phase 4 Piperacillin/tazobactam;Ceftazidim;Meropenem;Vancomycin
4 Ciprofloxacin for Prevention of BK Infection Unknown status NCT01789203 Phase 4 Ciprofloxacin;placebo
5 Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO Unknown status NCT02149329 Phase 4 Discontinuation of imipenem-cilastatin or meropenem
6 Oral Vancomyin for Primary Clostridium Difficile Infection Prophylaxis in Patients Receiving High-Risk Antibiotics Completed NCT02951702 Phase 4 Vancomycin Oral
7 Study to Evaluate the Pharmacokinetics of Fidaxomicin in Inflammatory Bowel Disease (IBD) Subjects With Clostridium Difficile Infection (CDI) Completed NCT02437591 Phase 4 fidaxomicin
8 Study to Assess Inhibition of Spore Production in Patients With C. Difficile Infections: Fidaxomicin Versus Vancomycin Completed NCT01818141 Phase 4 Vancomycin;Fidaxomicin
9 A Phase IIIB/IV Study to Compare the Efficacy of Vancomycin Therapy to Extended Duration of Fidaxomicin Therapy in the Clinical Cure of Clostridium Difficile Infection (CDI) in an Older Population Completed NCT02254967 Phase 4 Fidaxomicin;Vancomycin
10 Rifaximin for Preventing Relapse of Clostridium Associated Diarrhoea Completed NCT01670149 Phase 4 Rifaximin;Placebo
11 Stress Ulcer Prophylaxis in the Intensive Care Unit Completed NCT02467621 Phase 4 Pantoprazole
12 Postoperative Antibiotic Requirements Following Immediate Breast Reconstruction Completed NCT01244698 Phase 4 Cefadroxil discontinued early;Cefadroxil until drain removal
13 Perioperative Fosfomycin in the Prophylaxis of Urinary Tract Infection in Kidney Transplant Recipients Completed NCT03235947 Phase 4 Fosfomycin disodium;Trimethoprim / Sulfamethoxazole;Intravenous placebo
14 Screening to Prophylax Against Clostridium Difficile Infection - Recruiting NCT02996487 Phase 4 Vancomycin
15 A Comparison of Fidaxomicin and Vancomycin in Patients With CDI Receiving Antibiotics for Concurrent Infections Recruiting NCT02692651 Phase 4 Fidaxomicin;Vancomycin
16 Optimal Treatment for Recurrent Clostridium Difficile Recruiting NCT02667418 Phase 4 Fidaxomicin;Vancomycin with Taper/Pulse;Vancomycin
17 C. Difficile and Ursodiol Recruiting NCT02748616 Phase 4 Ursodiol
18 Standardized Fecal Microbiota Transplantation for Crohn&Apos;s Diseases Recruiting NCT01793831 Phase 4
19 Seven Versus Fourteen Days of Treatment in Uncomplicated Staphylococcus Aureus Bacteremia Recruiting NCT03514446 Phase 4 Antibiotic therapy duration for 7 days
20 Antibiotics to Decrease Post ERCP Cholangitis Recruiting NCT03087656 Phase 4 Ceftriaxone;Levofloxacin
21 GRam Stain-guided Antibiotics ChoicE for Ventilator-Associated Pneumonia (GRACE-VAP) Trial Recruiting NCT03506113 Phase 4 Gram stain-guided antibiotic choice;Guidelines-based antibiotics choice
22 Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial Recruiting NCT02462590 Phase 4 L. rhamnosus GG - Probiotic;Placebo - Microcrystalline Cellulose
23 Oral Vancomycin to Prevent Recurrent C Difficile Infection With Antibiotics Enrolling by invitation NCT03466502 Phase 4 Oral Vancomycin
24 Oral Vancomycin for Preventing Clostridium Difficile Recurrence Enrolling by invitation NCT03200093 Phase 4 Oral Vancomycin;Placebo
25 TOX NEG Trial: Clostridium Difficile Diagnosis and Treatment Enrolling by invitation NCT03388268 Phase 4 Oral Vancomycin;Placebo
26 Treatment of Clostridium Difficile in Colonized Patients in the Hematology Oncology Population Not yet recruiting NCT03030248 Phase 4 Vancomycin Oral Capsule;Placebo Oral Capsule
27 Efficacy of Loperamide for C. Difficile Colitis and Other Diarrheal Diseases Associated With Antibiotic Therapy Suspended NCT00591357 Phase 4 loperamide;placebo
28 Study of Bio-K+® in the Reduction of the Risk of Clostridium Difficile Infection and Antibiotic Associated Diarrhea Terminated NCT01972932 Phase 4
29 Use Of Oral Fidaxomicin Vs. Oral Vancomycin For Clostridium Difficile Infection In Patients With Spinal Cord Injury Terminated NCT02355938 Phase 4 Fidaxomicin 200 mg;Placebo;Vancomycin
30 A Post-marketing, Blinded Study to Investigate How Effective Fidaxomicin is Compared to Vancomycin in the Sustained Cure of Clostridium Difficile Infection in Adults That Are Receiving Therapy to Suppress the Immune System Terminated NCT01775397 Phase 4 Fidaxomicin;Vancomycin;Placebo
31 Efficacy of Metronidazole Prophylaxis Against Clostridium Difficile-Associated Diarrhea in High Risk Adult Patients Terminated NCT02200328 Phase 4 Metronidazole;Placebo
32 Fidaxomicin Versus Standard of Care Therapy in Solid Organ Transplant Recipients With Clostridium Difficile Infection Withdrawn NCT02464306 Phase 4 fidaxomicin
33 Use of Bismuth Subsalicylate in Clostridium Difficile Colitis Withdrawn NCT03592082 Phase 4 Bismuth Subsalicylate;standard antibiotic therapy
34 Fidaxomicin to Prevent Clostridium Difficile Colonization Withdrawn NCT01552668 Phase 4 Fidaxomicin;Placebo
35 Addition of Lactobacillus to Metronidazole in Treatment of CDAD Withdrawn NCT00304863 Phase 4 Lactobacillus GG
36 Temocillin Use in Complicated Urinary Tract Infections Due to Extended Spectrum Beta-Lactamases (ESBL)/AmpC Enterobacteriaceae Withdrawn NCT01543347 Phase 4 Temocillin
37 Transplantation of Fecal Microbiota for Clostridium Difficile Infection Unknown status NCT01958463 Phase 3
38 Randomized Controlled Trial Comparing Long and Short Duration of Antibiotic Prophylaxis for Patients Undergoing Sinus Lift Surgery Unknown status NCT02764710 Phase 3 Amoxicillin-Potassium Clavulanate Combination
39 A Study of MK-3415, MK-6072, and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-001) Completed NCT01241552 Phase 3 SOC
40 A Study of MK-6072 and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-002) Completed NCT01513239 Phase 3 SOC
41 Compassionate Use of Nitazoxanide for the Treatment of Clostridium Difficile Infection Completed NCT00304356 Phase 3 Nitazoxanide
42 Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile-associated Diarrhea Completed NCT01983683 Phase 3 Cadazolid;Vancomycin;Cadazolid-matching placebo;Vancomycin-matching placebo
43 Efficacy and Safety of Cadazolid Versus Vancomycin in Subjects With Clostridium Difficile - Associated Diarrhea Completed NCT01987895 Phase 3 Cadazolid;Vancomycin;Cadazolid-matching placebo;Vancomycin-matching placebo
44 A Study of CB-183,315 in Participants With Clostridium Difficile Associated Diarrhea (MK-4261-006) Completed NCT01598311 Phase 3 CB-183,315;Vancomycin;Placebo
45 Study of CB-183,315 in Participants With Clostridium Difficile Associated Diarrhea (MK-4261-005) Completed NCT01597505 Phase 3 Surotomycin;Vancomycin;Placebo
46 Probiotic Lactobacillus Reuteri to Prevent Antibiotic-associated Diarrhea and Clostridium Difficile-related Infections in Hospitalized Children Completed NCT01295918 Phase 3
47 A Study of GT267-004 Versus Vancomycin and GT267-004 Versus Metronidazole in Patients With C.Difficile - Associated Diarrhea Completed NCT00106509 Phase 3 tolevamer potassium-sodium (GT267-004)
48 Re-Evaluating the Inhibition of Stress Erosions: Gastrointestinal Bleeding Prophylaxis In ICU Completed NCT02290327 Phase 3 Pantoprazole;Placebo
49 Efficacy of Metronidazole Versus Metronidazole and Rifampin in CDAD Treatment Completed NCT00182429 Phase 3 Metronidazole and Rifampin
50 Prospective Randomized Trial of Seminal Vesicle-Sparing Prostatectomy and Nerve-Sparing Radical Prostatectomy in Men With Clinically Localized Prostate Cancer Completed NCT01825642 Phase 2, Phase 3

Search NIH Clinical Center for Clostridium Difficile Colitis

Cochrane evidence based reviews: enterocolitis, pseudomembranous

Genetic Tests for Clostridium Difficile Colitis

Anatomical Context for Clostridium Difficile Colitis

MalaCards organs/tissues related to Clostridium Difficile Colitis:

41
Colon, Liver, Lung, Spinal Cord, Prostate, Skin, Kidney

Publications for Clostridium Difficile Colitis

Articles related to Clostridium Difficile Colitis:

(show top 50) (show all 859)
# Title Authors Year
1
How Common-and How Serious- Is Clostridium difficile Colitis After Geriatric Hip Fracture? Findings from the NSQIP Dataset. ( 29443839 )
2018
2
Editor's Spotlight/Take 5: How Common-and How Serious-Is Clostridium difficile Colitis After Geriatric Hip Fracture? Findings from the NSQIP Dataset. ( 29443838 )
2018
3
Frailty Predicts Morbidity and Mortality after Colectomy for Clostridium difficile Colitis. ( 29966560 )
2018
4
A case report of successful management of clostridium difficile colitis with antegrade Fidaxomicin through a mucous fistula obviating the need for subtotal colectomy. ( 29227855 )
2018
5
Reducing Clostridium difficile Colitis Rates Via Cost-Saving Diagnostic Stewardship. ( 29611494 )
2018
6
Prolonged antibiotic use leading to Clostridium difficile colitis in an ill returned traveller with acute fascioliasis. ( 29608740 )
2018
7
Clostridium difficile colitis and zoonotic origins-a narrative review. ( 30151199 )
2018
8
A Case of Concomitant Emphysematous Cystitis and Clostridium difficile Colitis with Pneumoperitoneum. ( 30181931 )
2018
9
A Prospective Program to Reduce the Clinical Incidence of Clostridium Difficile Colitis Infection after Cystectomy. ( 30218764 )
2018
10
No survival advantage exists for patients undergoing loop ileostomy for clostridium difficile colitis. ( 30266417 )
2018
11
Infant progressive colonic stenosis caused by antibiotic-related Clostridium difficile colitis - a case report and literature review. ( 30301467 )
2018
12
Bezlotoxumab use as adjunctive therapy with the third fecal microbiota transplant in refractory recurrent Clostridium difficile colitis; a case report and concise literature review. ( 30521856 )
2018
13
Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis. ( 30451870 )
2018
14
Pseudomembranous colitis presenting as a mechanical large bowel obstruction. ( 27457536 )
2018
15
Pseudomembranous colitis in acute lymphoblastic leukaemia. ( 29500180 )
2018
16
Serum-Derived Bovine Immunoglobulin as Novel Adjunct in Complicated Clostridium difficile Colitis Treatment. ( 28516109 )
2017
17
Acute Appendicitis: An Extracolonic Manifestation of Clostridium difficile Colitis. ( 28757875 )
2017
18
Can Procalcitonin Contribute to the Diagnosis of Clostridium difficile Colitis? ( 28513121 )
2017
19
Clostridium difficile colitis: A clinical review. ( 28131326 )
2017
20
Effects of a New Hospital-Wide Surgical Consultation Protocol in Patients with Clostridium difficile Colitis. ( 28557651 )
2017
21
Polyethylene glycol intestinal lavage in addition to usual antibiotic treatment for severe Clostridium difficile colitis: a randomised controlled pilot study. ( 28760801 )
2017
22
Clostridium Difficile, Colitis, and Colonoscopy: Pediatric Perspective. ( 28707191 )
2017
23
Differentiating Clostridium difficile Colitis from Clostridium difficile Colonization in Ulcerative Colitis: A Role for Procalcitonin. ( 29032373 )
2017
24
Protection of Hamsters from Mortality by Reducing Fecal Moxifloxacin Concentration with DAV131A in a Model of Moxifloxacin-Induced Clostridium difficile Colitis. ( 28739791 )
2017
25
Intracolonic Vancomycin Through Laprascopic Appendicostomy for Treatment of Severe Clostridium difficile Colitis Does Not Get Systemic Absorption. ( 28301334 )
2017
26
Incidence, Risk Factors, and Impact of Clostridium difficile Colitis Following Primary Total Hip and Knee Arthroplasty. ( 28870746 )
2017
27
The risk for Clostridium difficile colitis during hospitalization in asymptomatic carriers. ( 28202190 )
2017
28
IVIG - A cure to severe refractory NAP-1 Clostridium difficile colitis? A case of successful treatment of severe infection, which failed standard therapy including fecal microbiota transplants and fidaxomicin. ( 28331803 )
2017
29
Incidence, Risk Factors, and Impact of Clostridium Difficile Colitis After Spine Surgery: An Analysis of a National Database. ( 28953711 )
2017
30
Risk Factors and Costs Associated With Clostridium difficile Colitis in Patients With Prosthetic Joint Infection Undergoing Revision Total Hip Arthroplasty. ( 29273290 )
2017
31
Use of tigecycline for the management of Clostridium difficile colitis in oncology patients and case series of breakthrough infections. ( 28153556 )
2017
32
A Curiously Rare Case of Septic Shock From Clostridium difficile Colitis. ( 26221790 )
2017
33
Pseudomembranous colitis from cytomegalovirus infection. ( 28397703 )
2017
34
An unusual case of Escherichia coli O157:H7 infection with pseudomembranous colitis-like lesions associated with haemolytic-uraemic syndrome and neurological sequelae. ( 28630239 )
2017
35
Pseudomembranous colitis. ( 29025036 )
2017
36
Successful Therapy of Severe Pseudomembranous Clostridium difficile Colitis using Combination of Fecal Microbiota Therapy and Fidaxomicin. ( 27978522 )
2016
37
Clostridium difficile colitis: pathogenesis and host defence. ( 27573580 )
2016
38
Vesicoileal fistula and Clostridium difficile colitis in a child with acute lymphoblastic leukemia. ( 27842209 )
2016
39
Novel therapies for severe Clostridium difficile colitis. ( 26771898 )
2016
40
A case of reactive arthritis due to Clostridium difficile colitis. ( 26908381 )
2016
41
Identification of Signet Ring Cell Change in Colonic Subserosa in the Setting of Clostridium difficile Colitis: Report of a Nonneoplastic Mimicker of Signet Ring Cell Carcinoma. ( 27562801 )
2016
42
Blastocystis sp. Infection Mimicking Clostridium Difficile Colitis. ( 27247810 )
2016
43
Preclinical development of Ramizol, an antibiotic belonging to a new class, for the treatment of Clostridium difficile colitis. ( 27189122 )
2016
44
Coexisting cytomegalovirus infection in immunocompetent patients with Clostridium difficile colitis. ( 26850320 )
2016
45
The efficacy of intracolonic vancomycin for severe Clostridium difficile colitis: a case series. ( 27388627 )
2016
46
Adult Intussusception Caused by Ileocecal Clostridium difficile Pseudomembranous Colitis. ( 27457842 )
2016
47
Adult Intussusception Caused by Ileocecal Clostridium difficile Pseudomembranous Colitis. ( 30454305 )
2016
48
Recurrent Pseudomembranous Colitis in an Ovarian Cancer Patient Undergoing Carboplatin Chemotherapy. ( 27051544 )
2016
49
"Clostridium difficile associated pseudomembranous colitis: An under-recognized threat" - Scenario from a Tertiary Care Hospital. ( 27080803 )
2016
50
Pseudomembranous colitis secondary to methicillin-resistant Staphylococcus aureus (MRSA). ( 27165998 )
2016

Variations for Clostridium Difficile Colitis

Expression for Clostridium Difficile Colitis

Search GEO for disease gene expression data for Clostridium Difficile Colitis.

Pathways for Clostridium Difficile Colitis

Pathways related to Clostridium Difficile Colitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.78 CDC42 IL1B LEPR
2
Show member pathways
11.49 CCR6 DEFA3 LTF
3 10.13 IL1B TOX

GO Terms for Clostridium Difficile Colitis

Cellular components related to Clostridium Difficile Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 8.8 CDC42 IL1B LTF

Biological processes related to Clostridium Difficile Colitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 humoral immune response GO:0006959 9.55 CCR6 LTF
2 antimicrobial humoral response GO:0019730 9.54 DEFA3 LTF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.54 IL1B LTF PSMA6
4 positive regulation of neuron apoptotic process GO:0043525 9.52 CDC42 IL1B
5 killing of cells of other organism GO:0031640 9.51 DEFA3 LTF
6 potassium ion import across plasma membrane GO:1990573 9.49 ATP12A ATP4A
7 potassium ion import GO:0010107 9.48 ATP12A ATP4A
8 antibacterial humoral response GO:0019731 9.46 DEFA3 LTF
9 ATP hydrolysis coupled proton transport GO:0015991 9.43 ATP12A ATP4A
10 innate immune response in mucosa GO:0002227 9.4 DEFA3 LTF
11 cellular sodium ion homeostasis GO:0006883 9.32 ATP12A ATP4A
12 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.26 ATP12A ATP4A
13 cellular potassium ion homeostasis GO:0030007 9.16 ATP12A ATP4A
14 sodium ion export across plasma membrane GO:0036376 8.96 ATP12A ATP4A
15 membrane disruption in other organism GO:0051673 8.62 DEFA3 LTF

Molecular functions related to Clostridium Difficile Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Clostridium Difficile Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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