CTEV
MCID: CLB002
MIFTS: 47

Clubfoot (CTEV)

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Clubfoot

MalaCards integrated aliases for Clubfoot:

Name: Clubfoot 12 74 52 54 43 15
Talipes 52 29 6
Congenital Talipes Equinovarus 12 52
Congenital Clubfoot 12 36
Equinovarus Deformity of Foot 12
Congenital Equinovarus 12
Talipes Equinovarus 52
Club Foot 54
Ctev 52

Classifications:



External Ids:

Disease Ontology 12 DOID:11836
KEGG 36 H00903
ICD9CM 34 754.51
MeSH 43 D003025
NCIt 49 C84641
SNOMED-CT 67 15169008 33163000
ICD10 32 Q66.0 Q66.89
UMLS 71 C0009081

Summaries for Clubfoot

NIH Rare Diseases : 52 Talipes equinovarus is a congenital (present from birth) condition where the foot turns inward and downward . The cause of this condition is not known, although it may be passed down through families in some cases. This condition occurs in about 1 out of every 1,000 births. Treatment may involve moving the foot into the correct position and using a cast to keep it there. This process is done in small increments over a period of time. In severe cases, surgery may be needed.

MalaCards based summary : Clubfoot, also known as talipes, is related to arthrogryposis, distal, type 2b1 and brachydactyly, type a4. An important gene associated with Clubfoot is SLC26A2 (Solute Carrier Family 26 Member 2), and among its related pathways/superpathways are Cardiac conduction and Striated Muscle Contraction. The drugs Acetylcholine and incobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and brain, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 A bone development disease where one or both are inclined inwards, axially rotated outwards, and pointing downwards with concomitant soft tissue abnormalities.

KEGG : 36 Congenital clubfoot is an idiopathic deformity of the lower limb that consists of malalignment of the bones and joints of the foot and ankle. It is defined as a fixation of the foot in a hand-like orientation. The calcaneus, navicular and cuboid bones are medially rotated in relation to talus. PITX1 haploinsufficiency accounts for the disease by causing developmental field defect during embryogenesis.

Wikipedia : 74 Clubfoot is a birth defect where one or both feet are rotated inward and downward. The affected foot and... more...

Related Diseases for Clubfoot

Diseases related to Clubfoot via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 267)
# Related Disease Score Top Affiliating Genes
1 arthrogryposis, distal, type 2b1 32.5 TPM2 TNNT3 MYH3
2 brachydactyly, type a4 32.0 HOXD13 HOXD12
3 spondyloepiphyseal dysplasia with congenital joint dislocations 31.6 SLC26A2 COL2A1 CHST3 CHST14
4 larsen syndrome 31.4 SLC26A2 CHST3 CHST14
5 congenital contractures 30.8 TNNT3 CHST14
6 chromosome 17q23.1-q23.2 deletion syndrome 30.4 TBX4 PITX1
7 distal arthrogryposis 30.1 TPM2 TNNT3 TGFB3 MYH8 MYH3 MYBPC1
8 brachydactyly 29.7 HOXD13 HOXD12 HOXD10 COL2A1
9 multiple pterygium syndrome, escobar variant 29.6 TPM2 TNNT3 MYH8 MYH3 ECEL1
10 clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly 12.8
11 esophageal atresia coloboma talipes 12.2
12 familial clubfoot with or without associated lower limb anomalies 12.2
13 robin sequence with cleft mandible and limb anomalies 12.1
14 musculocontractural ehlers-danlos syndrome 12.0
15 arthrogryposis, distal, type 3 11.9
16 tarp syndrome 11.9
17 ehlers-danlos syndrome, musculocontractural type, 1 11.8
18 crane-heise syndrome 11.7
19 chromosome 17q23.1-q23.2 duplication syndrome 11.6
20 arthrogryposis, distal, type 1a 11.6
21 alkuraya-kucinskas syndrome 11.5
22 cyprus facial neuromusculoskeletal syndrome 11.5
23 radial defect robin sequence 11.4
24 popliteal pterygium syndrome 11.4
25 dyssegmental dysplasia, silverman-handmaker type 11.4
26 acromelic frontonasal dysostosis 11.4
27 epiphyseal dysplasia, multiple, 4 11.4
28 vertical talus, congenital 11.4
29 myopathy, congenital, bailey-bloch 11.4
30 moebius syndrome 11.4
31 arthrogryposis, distal, type 2a 11.4
32 myotonic dystrophy 11.4
33 spondyloepimetaphyseal dysplasia, strudwick type 11.3
34 lambert syndrome 11.3
35 atelosteogenesis, type ii 11.3
36 genitopatellar syndrome 11.3
37 arthrogryposis, distal, type 7 11.3
38 charge syndrome 11.3
39 pseudoainhum 11.3
40 aase-smith syndrome i 11.2
41 diastrophic dysplasia 11.2
42 pseudodiastrophic dysplasia 11.2
43 arthrogryposis, distal, type 5d 11.2
44 loeys-dietz syndrome 5 11.2
45 saul-wilson syndrome 11.2
46 catel-manzke syndrome 11.1
47 karak syndrome 11.1
48 brachydactyly-distal symphalangism syndrome 11.0
49 kniest dysplasia 11.0
50 spondyloepiphyseal dysplasia congenita 11.0

Graphical network of the top 20 diseases related to Clubfoot:



Diseases related to Clubfoot

Symptoms & Phenotypes for Clubfoot

GenomeRNAi Phenotypes related to Clubfoot according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 10.03 HOXC13
2 Decreased viability GR00240-S-1 10.03 MYH3
3 Decreased viability GR00381-A-1 10.03 MYH3 SLC26A2
4 Decreased viability GR00402-S-2 10.03 CHST14 CHST3 COL2A1 ECEL1 GDAP1 HOXC12
5 no effect GR00402-S-1 9.62 CHST14 CHST3 COL2A1 ECEL1 GDAP1 HOXC12

MGI Mouse Phenotypes related to Clubfoot:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.77 CHST14 COL2A1 GDAP1 HOXC12 HOXC13 HOXD10
2 skeleton MP:0005390 9.44 CHST14 CHST3 COL2A1 ECEL1 HOXC13 HOXD10

Drugs & Therapeutics for Clubfoot

Drugs for Clubfoot (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
2 incobotulinumtoxinA Phase 4
3 Acetylcholine Release Inhibitors Phase 4
4 Neuromuscular Agents Phase 4
5 abobotulinumtoxinA Phase 4
6 Botulinum Toxins Phase 4
7 Cholinergic Agents Phase 4
8 Botulinum Toxins, Type A Phase 4
9
Ketamine Approved, Vet_approved Phase 2, Phase 3 6740-88-1 3821
10
Bupivacaine Approved, Investigational Phase 2, Phase 3 38396-39-3, 2180-92-9 2474
11 Anesthetics Phase 3
12 Anesthetics, Local Phase 2, Phase 3
13 Anesthetics, General Phase 2, Phase 3
14 Anesthetics, Dissociative Phase 2, Phase 3
15 Anesthetics, Intravenous Phase 2, Phase 3
16 Central Nervous System Depressants Phase 2, Phase 3
17 Excitatory Amino Acids Phase 2, Phase 3
18 Excitatory Amino Acid Antagonists Phase 2, Phase 3
19 Hemagglutinins Phase 2
20
Adenosine Approved, Investigational 58-61-7 60961
21 Astragalus
22 Neuroserpin
23 Neurotransmitter Agents
24 Pharmaceutical Solutions
25 Analgesics
26 Anti-Arrhythmia Agents
27 Vasodilator Agents

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 Effects of Repeated Use of Botulinum Neurotoxin Type A (BoNT/A) Free of Complexing Proteins in the Spastic Equinovarus Foot in Stroke Patients: A Randomized Clinical Trial Completed NCT03044080 Phase 4 IncobotulinumtoxinA;OnabotulinumtoxinA
2 Video and Temporal Spatial Parameters Assessment of Gait After Dysport Treatment. A Pilot Study Recruiting NCT03501043 Phase 4 Dysport
3 Study of the Efficacy of the Selective Neurotomy in the Treatment of the Spastic Equinovarus Foot Among Adult Hemiplegic Patient Following the ICF Model. A Prospective, Randomized, Controlled Single Blind Study Completed NCT00825097 Phase 3 Botulinum toxin injection
4 Infra-orbital Nerve Block for Post Operative Analgesia in Young Children Undergoing Pediatric Cleft Lip Surgery. Completed NCT02514980 Phase 2, Phase 3 Bupivacaine;Ketamine
5 Multi-center Open Comparative Randomized Trial of Clinical and Neurophysiological Efficacy and Safety of Xeomin (Botulinum Toxin Type A) vs. Botox (Complex of Botulinum Toxin Type A and Hemagglutinin) in Children With Spastic Equine and Equinovarus Foot Deformation in Pediatric Cerebral Palsy Completed NCT02188277 Phase 2 Xeomin;Botox®
6 Treatment of Idiopathic Clubfoot Utilizing Botulinum Toxin A: A New Treatment for Correction Unknown status NCT00152334 Botox
7 A Retrospective Multicenter Analysis on Treatment of Congenital Idiopathic Clubfoot With Minimally Invasive Carroll's Technique Unknown status NCT02815215 Early Phase 1
8 Effectiveness of Sucrose Analgesia in Infants Undergoing Casting for Club Foot Unknown status NCT01050088
9 Natural History and Effectiveness of Parents' Manipulation in Newborn With Talipes Calcaneovalgus,a Randomized Controlled Trial Unknown status NCT01767662
10 Pedobarographic Assessments of Clubfoot Treated Patients Unknown status NCT00175708
11 Do Physical Manipulation Exercises With EPAT Improve Ankle Dorsiflexion and Reduce Dynamic Plantar Forefoot Pressure in Diabetic Subjects With Equinus?: A Pilot RCT Unknown status NCT02233140
12 Prospective Randomized Controlled Trial Comparing Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer. Unknown status NCT01751503
13 Genetic Disease Gene Identification Unknown status NCT00916903
14 The Pma Mouse and the Developmental Basis of Clubfoot: MRI Anatomical Modelling of Human ICTEV (Clubfoot) Completed NCT01088828
15 Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot) Completed NCT00474344
16 Polyaxial Brace Fixing for the Treatment of Congenital Clubfoot in Newborns and Infants Completed NCT02815306
17 Clubfoot DNA Repository Completed NCT00607191
18 A Double-Blind, Randomized Control Trial Comparing Botulinum Toxin Type A (Botox) and Placebo in the Treatment of Idiopathic Clubfoot Completed NCT00152347 Botox
19 Genetic and Clinical Studies of Congenital Anomaly Syndromes Completed NCT00001404
20 Comparison of Two Different Cast Materials for the Treatment of Congenital Idiopathic Clubfoot Using the Ponseti Method: A Prospective Randomized Controlled Trial Completed NCT01067651
21 Measurement of Compliance in Clubfoot Bracing Via a Novel Pressure Sensor Completed NCT01481324
22 A Post Marketing Surveillance Study of Dysport Formulated With a Batch of Bulk Active Substance From a New Primary Manufacturing Facility at the Centre for Applied Microbiology & Research. Completed NCT00210431
23 Normalization of Forefoot Supination After Tibialis Anterior Tendon Transfer for Dynamic Clubfoot Recurrence Completed NCT03953430
24 Results of Gait Analysis Including Oxford Foot Model in Children With Clubfoot Treated With the Ponseti Method Completed NCT02022267
25 A Randomized Controlled Trial of Three Non-pharmacologic Analgesic Techniques for Casting of Clubfoot Infants Completed NCT02395185
26 Development of Child With Equinus Deformity Idiopathic Completed NCT03382028
27 Treatment of Spastic Equinovarus Foot After Stroke. Efficacy: Association Between Ankle Foot Orthosis and Botulinum Toxin A (BTA) Injection Completed NCT00199589 Botulinic toxin (Botox)
28 Efficiency of Botulinum Toxin Injection for Spastic Equinovarus Foot in Post Stroke Hemiparetic Patients Randomized Controlled Trial Versus Placebo Completed NCT03405948 Intra muscular injection of Botulinum toxin
29 Study of the Efficacy and Safety of the Neuro-orthopaedic Surgery in the Treatment of the Spastic Equinovarus Foot With ICF Assessment Completed NCT01265238
30 Children Born With Club Feet: Ultrasound Diagnosis and Antenatal Assessment Completed NCT03671863
31 Determination of the Pathophysicologic Collagen Changes in the Diabetic Achilles Tendon. Completed NCT01382628
32 Impairments of Oral Language in Subjects With the Möbius Sequence Completed NCT00856531
33 Customized Orthosis for Children With Clubfoot Following Ponseti Casting Recruiting NCT03853811
34 Efficacy of Botox in Patients With Idiopathic Clubfoot Recruiting NCT00474032 Botulinum Toxin (Type A) injection (10 U/Kg)
35 Trial Readiness and Endpoint Assessment in Congenital Myotonic Dystrophy Recruiting NCT03059264
36 Prospective Evaluation of Treatment for Clubfoot Recruiting NCT02257229
37 Efficacy of a New Design of Foot Abduction Brace (FAB) Compared to Standard FAB During Ponseti Treatment of Idiopathic Clubfoot by Measuring Rate of Recurrence and Compliance Using Novel Touch Sensors Recruiting NCT03249805
38 In Vivo Dynamic Evaluation of Ankle Joint and Muscle Mechanics in Children With Spastic Equinus Deformity Due to Cerebral Palsy: Implications for Recurrent Equinus. Recruiting NCT02814786
39 Efficacy and Safety of Nerve Root Axial Decompression Surgery in The Treatment of Tethered Cord Syndrome: A Conservative Treatment- Controlled, Randomized, Clinical Study Recruiting NCT03262844
40 Duration of Brace Wear in Clubfoot Treatment - A Prospective Randomized Trail Active, not recruiting NCT01551264
41 Bracing Compliance and Personality Traits: A Compliance Assessment Program for Scoliosis and Clubfeet Active, not recruiting NCT02755766
42 Osteopathic Approach Into Neonatology Ward: the NE-O Model Available NCT01902563
43 Rate Of Residual Clubfoot Deformity With Correlation To Absence Of Peroneus Tertius Muscle: A Prospective Study Not yet recruiting NCT03749265
44 Ankle Equinus Contracture Treated With Dynamic Splinting in a Randomized, Controlled Trial Terminated NCT01238484
45 The Effect of Botulinum Toxin A Injections on Ankle Dorsiflexion Following Internal Fixation of Tibial Plafond (Pilon) Fractures: A Pilot Study Terminated NCT02051933 Botox;Placebo
46 Freeman-Sheldon Syndrome Quality of Life Study (FSS-QLS): Cross-sectional Study of Concomitant Disorder-Specific Contributors to Quality of Life and Clinical Outcome Terminated NCT01307475
47 Comparison of Ponseti Method Versus Older Treatments in Talipes Equinovarus Through Gait Analysis and Clinical Results Withdrawn NCT03580746
48 Economic Evaluation of Clubfoot Treatment: One Centre's Experience Withdrawn NCT00475631
49 Surgical Treatment of Plantar Fasciitis: Instep Plantar Fasciotomy With and Without Gastrocnemius Recession Withdrawn NCT02287714

Search NIH Clinical Center for Clubfoot

Cochrane evidence based reviews: clubfoot

Genetic Tests for Clubfoot

Genetic tests related to Clubfoot:

# Genetic test Affiliating Genes
1 Talipes 29

Anatomical Context for Clubfoot

MalaCards organs/tissues related to Clubfoot:

40
Bone, Heart, Brain, Skin, Skeletal Muscle, Testes, Spinal Cord

Publications for Clubfoot

Articles related to Clubfoot:

(show top 50) (show all 3102)
# Title Authors PMID Year
1
Progressive aortic root and pulmonary artery aneurysms in a neonate with Loeys-Dietz syndrome type 1B. 54 61
20101701 2010
2
DTDST mutations are not a frequent cause of idiopathic talipes equinovarus (club foot). 54 61
11950872 2002
3
A mutation in COL9A1 causes multiple epiphyseal dysplasia: further evidence for locus heterogeneity. 54 61
11565064 2001
4
Clubfoot for the primary care physician: frequently asked questions. 61
31815780 2020
5
A comparative study of pedobarography and ankle kinematics between children with idiopathic clubfoot after a soft tissue release procedure and controls. 61
31796992 2020
6
Forefoot malformations, deformities and other congenital defects in children. 61
31648997 2020
7
The 5-Year Outcome of the Ponseti Method in Children With Idiopathic Clubfoot and Arthrogryposis. 61
32032217 2020
8
Difficulties During Ponseti Casting for the Treatment of Idiopathic Clubfoot. 61
31757753 2020
9
Comparison of two different methods in preoperative planning of the amount of lengthening in Z achilloplasty technique. 61
31425334 2020
10
Generation and characterization of a human iPSC line derived from congenital clubfoot amniotic fluid cells. 61
31986484 2020
11
Lower extremity characteristics in recurrent clubfoot: Clinical and gait analysis findings that may influence decisions for additional surgery. 61
31627119 2020
12
Confirmation of Tenotomy Healing at 3 Weeks Using the Ponseti Protocol. 61
31952922 2020
13
Perinatal outcomes of infants with congenital limb malformations: an observational study from a tertiary referral center in Central Europe. 61
31931744 2020
14
Can Repeated Ponseti Management for Relapsed Clubfeet Produce the Outcome Comparable With the Case Without Relapse? A Clinical Study in Term of Gait Analysis. 61
31815859 2020
15
Prevalence of Hip Dysplasia and Associated Conditions in Children Treated for Idiopathic Early-onset Scoliosis-Don't Just Look at the Spine. 61
30994578 2020
16
Integrated bioinformatics analysis of potential pathway biomarkers using abnormal proteins in clubfoot. 61
31998564 2020
17
Calpainopathy: Description of a Novel Mutation and Clinical Presentation with Early Severe Contractures. 61
31991774 2020
18
Value of routine ultrasound examination at 35-37 weeks' gestation in diagnosis of fetal abnormalities. 61
31595569 2020
19
Brace Yourselves: Outcomes of Ponseti Casting and Foot Abduction Orthosis Bracing in Idiopathic Congenital Talipes Equinovarus. 61
30969199 2020
20
Assessment of the talar deformity and alignment in congenital clubfoot using three-dimensional MRI after Ponseti method. 61
31866017 2019
21
Arthrodesis of the Foot or Ankle in Adult Patients with Congenital Clubfoot. 61
32025426 2019
22
Early Radiographic Changes in the Lateral Talocalcaneal Angle Following Achilles Tenotomy in Children With Idiopathic Clubfoot. 61
31855081 2019
23
Ten year challenge with Ponseti method for clubfoot: our experience. 61
31821296 2019
24
X-linked duplication copy number variation in a familial overgrowth condition. 61
31762227 2019
25
Associations between embryo grading and congenital malformations in IVF/ICSI pregnancies. 61
31606300 2019
26
Conjoined twins presenting with foot deformities: insights to management and challenges. 61
31826902 2019
27
Congenital talipes equinovarus (clubfoot). 61
31787157 2019
28
Septo-optic dysplasia with amniotic band syndrome sequence: a case report. 61
31839004 2019
29
Orthopedic findings in arthrogryposis and congenital Zika syndrome: A case series. 61
31891236 2019
30
Developing pathways to clarify pathogenicity of unclassified variants in Osteogenesis Imperfecta genetic analysis. 61
31568717 2019
31
Subclinical in utero Zika virus infection is associated with interferon alpha sequelae and sex-specific molecular brain pathology in asymptomatic porcine offspring. 61
31725819 2019
32
A Modified Ponseti Method for the Treatment of Rigid Idiopathic Congenital Clubfoot. 61
31679671 2019
33
Incidence and risk factors for iatrogenic distal tibia/fibula fracture during Ponseti technique of clubfoot treatment. 61
30741748 2019
34
YouTube as an information source for clubfoot: a quality analysis of video content. 61
31725533 2019
35
Complex Clubfoot Treatment With Ponseti Method: A Latin American Multicentric Study. 61
31688820 2019
36
A Long-term Follow-up of Young Adults With Idiopathic Clubfoot: Does Foot Morphology Relate to Pain? 61
31599864 2019
37
The Ponseti Method Decreased the Surgical Incidence in Children with Congenital Clubfoot: A Population-Based, 8 Birth-Year Cohort Study. 61
31567679 2019
38
A new anchoring technique for tibialis anterior tendon transfer. 61
31725537 2019
39
Outcome of isolated fetal talipes: A systematic review and meta-analysis. 61
31034582 2019
40
Management of pediatric foot deformities: an imaging review. 61
31686173 2019
41
A CARE-compliant article: A case report of scoliosis complicated with multicentric carpotarsal osteolysis. 61
31770198 2019
42
Genome-wide association studies of structural birth defects: A review and commentary. 61
31654503 2019
43
National population-based estimates for major birth defects, 2010-2014. 61
31580536 2019
44
[Surgical treatment of limb deformity and disability: a statistical analysis of 35 075 cases from QIN Sihe orthopaedic team between May 25, 1978 and December 31, 2018]. 61
31650744 2019
45
Factors Related to Early Recurrence of Idiopathic Clubfoot Post the Ponseti Method. 61
31890107 2019
46
Simultaneous lateral column shortening along with differential distraction by Joshi's external stabilization system for rigid neglected clubfoot correction. 61
30702637 2019
47
Bart syndrome associated with skeletal deformities: An uncommon case report. 61
31631476 2019
48
The Validity of Patient-reported Outcome Measurement Information System (PROMIS) Parent Proxy Instruments to Assess Function in Children With Talipes Equinovarus. 61
30913133 2019
49
Assessing public awareness of clubfoot and knowledge about the importance of early childhood treatment: a cross-sectional survey. 61
31623581 2019
50
Standing and walking age in children with idiopathic clubfoot: French physiotherapy versus Ponseti method. 61
31695814 2019

Variations for Clubfoot

ClinVar genetic disease variations for Clubfoot:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 46;XX;t(7;13)(p13;q34)dnTranslocation Pathogenic 267841

Expression for Clubfoot

Search GEO for disease gene expression data for Clubfoot.

Pathways for Clubfoot

GO Terms for Clubfoot

Cellular components related to Clubfoot according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.63 TBX4 PITX1 HOXD13 HOXD12 HOXD10 HOXC13
2 muscle myosin complex GO:0005859 9.26 MYH8 MYH3
3 myofibril GO:0030016 9.13 MYH8 MYH3 MYBPC1
4 myosin filament GO:0032982 8.8 MYH8 MYH3 MYBPC1

Biological processes related to Clubfoot according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 10.04 TBX4 PITX1 HOXD13 HOXD12 HOXD10 HOXC13
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.99 TGFB3 TBX4 PITX1 HOXD13 HOXD10 HOXC13
3 multicellular organism development GO:0007275 9.95 TBX4 PITX1 HOXD13 HOXD12 HOXD10 HOXC13
4 muscle contraction GO:0006936 9.67 TPM2 TNNT3 MYH8 MYBPC1
5 anterior/posterior pattern specification GO:0009952 9.65 HOXD13 HOXD10 HOXC13
6 skeletal muscle contraction GO:0003009 9.5 TNNT3 MYH8 MYH3
7 hindlimb morphogenesis GO:0035137 9.46 PITX1 HOXD10
8 embryonic limb morphogenesis GO:0030326 9.46 TBX4 MYH3 HOXD13 HOXD10
9 regulation of ATPase activity GO:0043462 9.43 TPM2 TNNT3
10 limb morphogenesis GO:0035108 9.43 TBX4 HOXD13 COL2A1
11 skeletal system development GO:0001501 9.35 PITX1 HOXD13 HOXD12 HOXD10 COL2A1
12 muscle filament sliding GO:0030049 9.02 TPM2 TNNT3 MYH8 MYH3 MYBPC1

Molecular functions related to Clubfoot according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 10.03 ZNF664 TBX4 PITX1 HOXD13 HOXD12 HOXD10
2 sequence-specific DNA binding GO:0043565 9.8 PITX1 HOXD13 HOXD12 HOXD10 HOXC13 HOXC12
3 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.8 TBX4 PITX1 HOXD13 HOXD12 HOXD10 HOXC13
4 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.77 TBX4 PITX1 HOXD13 HOXD10 HOXC13
5 actin binding GO:0003779 9.55 TPM2 TNNT3 MYH8 MYH3 MYBPC1
6 microfilament motor activity GO:0000146 9.4 MYH8 MYH3
7 structural constituent of muscle GO:0008307 9.13 TPM2 MYH8 MYBPC1
8 myosin phosphatase activity GO:0017018 8.62 MYH8 MYH3

Sources for Clubfoot

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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