MCID: CLS010
MIFTS: 46

Cluster Headache

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Cluster Headache

MalaCards integrated aliases for Cluster Headache:

Name: Cluster Headache 53 37 55 73

Classifications:



External Ids:

KEGG 37 H01588
ICD10 33 G44.0
UMLS 73 C0009088

Summaries for Cluster Headache

NIH Rare Diseases : 53 Cluster headaches are a form of headache notable for their extreme pain and their pattern of occurring in "clusters", usually at the same time(s) of the day for several weeks. The headaches are accompanied by autonomic symptoms, and some people experience restlessness and agitation. A cluster headache begins with severe pain strictly on one side of the head, often behind or around one eye. In some people, it may be preceded by a migraine-like "aura." The pain usually peaks over the next 5 to 10 minutes, and then continues at that intensity for up to three hours before going away. Typical attacks may strike up to eight times a day and are relatively short-lived. On average, a cluster period lasts 6 to 12 weeks. Autonomic symptoms may include: conjunctival injection (bloodshot eyes), swelling under or around the eye, excessive tearing of the eyes, drooping of the eyelid, runny nose and/or nasal congestion, and forehead and facial sweating. These symptoms generally occur only during the pain attack and are on the same side as the headache pain. Cluster headaches usually begin between the ages of 20 and 50, although they can start at any age. Males are more commonly affected than females. Treatment can be divided into acute therapy aimed at stopping symptoms once they have started and preventive therapy aimed at preventing recurrent attacks during the cluster period.

MalaCards based summary : Cluster Headache is related to migraine with or without aura 1 and migraine without aura, and has symptoms including headache and recurrent paroxysmal headache. An important gene associated with Cluster Headache is HCRTR2 (Hypocretin Receptor 2), and among its related pathways/superpathways are Neuroscience and Myometrial Relaxation and Contraction Pathways. The drugs Sumatriptan and Betamethasone have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and hypothalamus, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Wikipedia : 76 Cluster headache (CH) is a neurological disorder characterized by recurrent severe headaches on one side... more...

Related Diseases for Cluster Headache

Diseases in the Cluster Headache family:

Cluster Headache, Familial

Diseases related to Cluster Headache via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 migraine with or without aura 1 29.8 CACNA1A CALCA VIP
2 migraine without aura 29.7 CACNA1A PRL
3 restless legs syndrome 29.4 CACNA1A CLOCK NOS1
4 bipolar disorder 28.9 CLOCK NOS1 PRL
5 cluster headache, familial 12.5
6 headache 11.8
7 paroxysmal hemicrania 11.6
8 hemicrania continua 10.9
9 carotid artery dissection 10.1
10 familial hemiplegic migraine 10.1 CACNA1A CALCA
11 hemiplegic migraine 10.1 CACNA1A CALCA
12 wdha syndrome 10.1 CALCA VIP
13 sleep apnea 10.1
14 leprosy 2 10.1 CALCA VIP
15 vasomotor rhinitis 10.1 CALCA VIP
16 pancreatic cholera 10.1 CALCA VIP
17 somatostatinoma 10.1 CALCA VIP
18 diffuse pulmonary fibrosis 10.1 CALCA VIP
19 hemiplegia 10.1 CACNA1A CALCA
20 islet cell tumor 10.1 CALCA VIP
21 acute thyroiditis 10.1 CALCA NOS1
22 alternating hemiplegia of childhood 10.1 CACNA1A CALCA
23 horner's syndrome 10.0
24 depression 10.0
25 prolactin producing pituitary tumor 10.0 CALCA PRL
26 ovarian cystic teratoma 10.0 CALCA PRL
27 constipation 10.0 CALCA VIP
28 anisocoria 10.0
29 multiple sclerosis 10.0
30 temporal arteritis 10.0
31 achalasia 9.9 NOS1 VIP
32 endocrine organ benign neoplasm 9.9 CALCA PRL
33 sleep disorder 9.9 HCRTR2 PRL
34 fibrous dysplasia 9.9 CALCA PRL
35 thyroid gland disease 9.9 CALCA PRL
36 tetrahydrobiopterin deficiency 9.9 NOS1 PRL
37 sexual disorder 9.9 NOS1 PRL
38 myositis 9.9
39 trigeminal neuralgia 9.9
40 lung cancer 9.9
41 cataract 9.9
42 sinusitis 9.9
43 thrombosis 9.9
44 migraine with aura 9.9
45 neuritis 9.9
46 acute maxillary sinusitis 9.9
47 maxillary sinusitis 9.9
48 glioblastoma 9.9
49 harlequin syndrome 9.9
50 head injury 9.9

Graphical network of the top 20 diseases related to Cluster Headache:



Diseases related to Cluster Headache

Symptoms & Phenotypes for Cluster Headache

UMLS symptoms related to Cluster Headache:


headache, recurrent paroxysmal headache

MGI Mouse Phenotypes related to Cluster Headache:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.63 CACNA1A CLOCK HCRTR2 NOS1 PRL VIP
2 endocrine/exocrine gland MP:0005379 9.35 CACNA1A CLOCK NOS1 PRL VIP
3 reproductive system MP:0005389 9.02 CACNA1A CLOCK NOS1 PRL VIP

Drugs & Therapeutics for Cluster Headache

Drugs for Cluster Headache (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 140)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sumatriptan Approved, Investigational Phase 4,Phase 3,Not Applicable 103628-46-2 5358
2
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
3
Rizatriptan Approved Phase 4 145202-66-0, 144034-80-0 5078
4
Bupivacaine Approved, Investigational Phase 4,Not Applicable,Early Phase 1 2180-92-9, 38396-39-3 2474
5
Triamcinolone Approved, Vet_approved Phase 4,Not Applicable 124-94-7 31307
6
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
7
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
8
Zolmitriptan Approved, Investigational Phase 4 139264-17-8 441240 60857
9
Topiramate Approved Phase 4 97240-79-4 5284627
10 Serotonin Agents Phase 4,Phase 3
11 Serotonin 5-HT1 Receptor Agonists Phase 4,Phase 3
12 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
13 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2,Not Applicable
14 Anesthetics, Local Phase 4,Phase 2,Not Applicable,Early Phase 1
15 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
16 Hormone Antagonists Phase 4,Phase 2
17 Anti-Asthmatic Agents Phase 4,Not Applicable
18 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
19 Betamethasone benzoate Phase 4
20 Betamethasone sodium phosphate Phase 4
21 Respiratory System Agents Phase 4,Not Applicable
22 Hormones Phase 4,Phase 2
23 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
24 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Not Applicable
25 Betamethasone-17,21-dipropionate Phase 4
26 Betamethasone Valerate Phase 4 2152-44-5
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
28 glucocorticoids Phase 4
29 Antineoplastic Agents, Hormonal Phase 4,Phase 1,Phase 2
30 Autonomic Agents Phase 4,Phase 1,Phase 2,Not Applicable
31 Antiemetics Phase 4,Phase 1,Phase 2,Not Applicable
32 Gastrointestinal Agents Phase 4,Phase 1,Phase 2,Not Applicable
33 HIV Protease Inhibitors Phase 4,Phase 2
34
protease inhibitors Phase 4,Phase 2
35 Anticonvulsants Phase 4,Not Applicable
36 Triamcinolone diacetate Phase 4,Not Applicable
37 Immunosuppressive Agents Phase 4
38 Immunologic Factors Phase 4
39 triamcinolone acetonide Phase 4,Not Applicable
40 Triamcinolone hexacetonide Phase 4,Not Applicable
41 BB 1101 Phase 4
42 Anti-Infective Agents Phase 4
43 Oxazolidinones Phase 4
44 Neuroprotective Agents Phase 4
45 Anti-Obesity Agents Phase 4
46 Protective Agents Phase 4
47
Serotonin Investigational, Nutraceutical Phase 4,Phase 3 50-67-9 5202
48
Sodium oxybate Approved Phase 3 502-85-2 5360545
49
Verapamil Approved Phase 2, Phase 3 52-53-9 2520
50
Capsaicin Approved Phase 3,Phase 1 404-86-4 1548943

Interventional clinical trials:

(show top 50) (show all 82)
# Name Status NCT ID Phase Drugs
1 Sumatriptan 4 mg Statdose in the Acute Treatment of Cluster Headache Unknown status NCT00399243 Phase 4 Sumatriptan 4mg Statdose injection
2 GON-block in Chronic Migraine: a Randomized, Double- Blind, Placebo-controlled Study Unknown status NCT02686983 Phase 4 Betamethasone and local anesthetic
3 Rizatriptan in Acute Treatment of Migraine in Patients With Unilateral Trigeminal-autonomic Symptoms. Completed NCT00753311 Phase 4 rizatriptan or placebo
4 A Comparison of Dexamethasone and Triamcinolone for Ultrasound-guided Occipital C2 Nerve Blocks Recruiting NCT02655523 Phase 4 Triamcinolone;Dexamethasone;Normal Saline;Bupivacaine
5 Efficacy and Safety of Zolmitriptan by Sublingual Administration Not yet recruiting NCT03377257 Phase 4 zolmitriptan by sublingual administration;zolmitriptan by oral
6 A Double-Blind, Placebo-Controlled Study Examining the Use of Topiramate in the Treatment of Cluster Headache Terminated NCT00203190 Phase 4 Topiramate
7 Sodium Oxybate in Patients With Episodic and Chronic Cluster Headache Unknown status NCT02637648 Phase 3 Sodium Oxybate;Placebo
8 A Study of LY2951742 in Participants With Episodic Cluster Headache Completed NCT02397473 Phase 3 LY2951742;Placebo
9 Anodal Transcranial Direct Stimulation (tDCS) for the Treatment of Chronic Cluster Headache Completed NCT02462395 Phase 2, Phase 3
10 Cluster Headache Cortivazol Injection (CHCI) Completed NCT00804895 Phase 2, Phase 3 ALTIM, cortivazol injections;PROAMP, subcutaneous serum physiological saline;Verapamil
11 Intranasal Civamide for Episodic Cluster Headache Completed NCT00069082 Phase 3 Civamide (Zucapsaicin);Sodium Chloride
12 A Phase III Study of Civamide Nasal Solution (Zucapsaicin) for the Treatment of Episodic Cluster Headache Completed NCT00033839 Phase 3 Civamide (Zucapsaicin)
13 Study Of Sumatriptan Succinate Injection Kit In Patients With Migraine or Cluster Headache In Japan Completed NCT00356603 Phase 3 Sumatriptan Succinate
14 A Study to Evaluate the Efficacy and Safety of TEV-48125 (Fremanezumab) for the Prevention of Episodic Cluster Headache (ECH) Recruiting NCT02945046 Phase 3 Fremanezumab - A;Fremanezumab - B;Placebo
15 A Study of LY2951742 in Participants With Chronic Cluster Headache Active, not recruiting NCT02438826 Phase 3 LY2951742;Placebo
16 Occipital Nerve Stimulation in Medically Intractable Chronic Cluster Headache Active, not recruiting NCT01151631 Phase 3
17 A Study of LY2951742 (Galcanezumab) in Participants With Cluster Headache Enrolling by invitation NCT02797951 Phase 3 Galcanezumab
18 A Study to Explore the Long-Term Safety of TEV-48125 (Fremanezumab) for the Prevention of Cluster Headache Enrolling by invitation NCT03107052 Phase 3 Fremanezumab
19 Civamide Nasal Solution for Cluster Headache Not yet recruiting NCT01341548 Phase 3 Civamide nasal solution 0.01%
20 A Study Comparing the Efficacy and Safety of TEV-48125 (Fremanezumab) for the Prevention of Chronic Cluster Headache (CCH) Terminated NCT02964338 Phase 3 Fremanezumab- A;Fremanezumab- B;Placebo
21 Randomized Evaluation of Octreotide Versus Compazine for Emergency Department Treatment of Migraine Headache Unknown status NCT00274170 Phase 1, Phase 2 Octreotide
22 Botox Injection in Treatment of Cluster Headache Completed NCT02019017 Phase 1, Phase 2 Botulinum Toxin Type A 25 IU;Botulinum Toxin Type A 50 IU
23 Prevention and Acute Treatment of Chronic Cluster Headache Compared to Standard of Care Completed NCT01701245 Phase 2
24 Prophylactic Treatment of Episodic Cluster Headache Completed NCT00184587 Phase 2 candesartan cilexetil;placebo
25 Occipital Nerve Stimulation to Treat Chronic Headaches Completed NCT00205894 Phase 1, Phase 2
26 Lysergic Acid Diethylamide (LSD) as Treatment for Cluster Headache Recruiting NCT03781128 Phase 2 Lysergic Acid Diethylamide;Placebo
27 Safety and Efficacy Study of SOM230 s.c. in Cluster Headache Recruiting NCT02619617 Phase 2 SOM230;Placebo
28 Botulinum Toxin Type A Block of the Otic Ganglion in Chronic Cluster Headache: Safety Issues Recruiting NCT03066635 Phase 1, Phase 2 Botulinum Toxin Type A 25 IU;Botulinum Toxin Type A 12.5 IU
29 Psilocybin-facilitated Treatment for Cocaine Use Recruiting NCT02037126 Phase 2 Psilocybin;Diphenhydramine
30 Pilot Study Evaluating the Use of Nasal Carbon Dioxide for the Treatment of Cluster Headache Terminated NCT02381795 Phase 2 Nasal Carbon Dioxide
31 R-Verapamil for the Prophylaxis of Episodic Cluster Headache Terminated NCT02209155 Phase 2 R-verapamil 75 mg tablet;Placebo
32 A Pilot Study of Demand Valve Oxygen Inhalation Therapy for Cluster Headache Unknown status NCT01298921 Phase 1 Oxygen;Oxygen
33 Psilocybin for the Treatment of Cluster Headache Recruiting NCT02981173 Phase 1 0.143 mg/kg Psilocybin;0.0143 mg/kg Psilocybin;Placebo
34 Pain Biomarker Study Active, not recruiting NCT03511846 Phase 1 Oral capsaicin;Topical capsaicin;Intranasal capsaicin;Low Flow Oxygen;High Flow Oxygen
35 Cluster Headache, Addictions and Vascular Function Unknown status NCT02640105
36 Cerebral Metabolism in Patients With Refractory Chronic Cluster Headache Treated by Occipital Nerve Stimulation Unknown status NCT02081482 Not Applicable
37 Physiotherapy Program for Cluster Headache Unknown status NCT02460003 Not Applicable
38 Baclofen in the Treatment of Muscle Cramps in Patients With Cirrhosis Unknown status NCT02221570 Not Applicable Baclofen
39 French Database of Occipital Nerves Stimulation in the Treatment of Refractory Chronic Headache Disorders Unknown status NCT01842763
40 Analysis of the Prevalence and Characteristics of Concomitant Sleep and Headache Disorders, and the Efficacy of CPAP Treatment for Headache Among Those Patients Diagnosed With Obstructive Sleep Apnea Unknown status NCT00520156
41 Inflammatory Markers Identification in Migraine Patients Unknown status NCT01618201
42 Identification of Inflammatory Markers in Migraine Patients Unknown status NCT00969995
43 Sleep in Cluster Headache: Sleep Parameters in- and Outside a Cluster Bout Completed NCT03439722
44 Circadian Rhythm and Attack-timing in Episodic Cluster Headache Patients in- and Outside of Bout: an Actigraphic Study Completed NCT02853487
45 Sleep, Circadian Rhythms and Cluster Headache Completed NCT01447641
46 Intranasal Cooling for Cluster Headache and Migraine Completed NCT01898455 Not Applicable
47 Non-invasive Neurostimulation of the Vagus Nerve for the Treatment of Cluster Headache Completed NCT01792817 Not Applicable
48 Cluster Headache and SPINK-1 Gene Completed NCT02585739 Not Applicable
49 Sphenopalatine Ganglion Stimulation for the Acute Treatment of Cluster Headache Completed NCT01255813 Not Applicable
50 Evaluation of Efficacity and Safety of Deep Brain Stimulation (DBS) in Chronic and Treatment-Resistant Cluster Headache(CH) Completed NCT00662935 Not Applicable

Search NIH Clinical Center for Cluster Headache

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Cluster Headache

Anatomical Context for Cluster Headache

MalaCards organs/tissues related to Cluster Headache:

41
Eye, Brain, Hypothalamus, Spinal Cord, Pituitary, Lung, Testes

Publications for Cluster Headache

Articles related to Cluster Headache:

(show top 50) (show all 1032)
# Title Authors Year
1
Neurostimulation for the treatment of chronic migraine and cluster headache. ( 30291633 )
2019
2
High dosage of methylprednisolone in cluster headache. ( 29904864 )
2018
3
If you want to understand what it really means to live with cluster headache, imagine... fostering empathy through European patients' own stories of their experiences. ( 29633698 )
2018
4
Sphenopalatine ganglion stimulation for cluster headache, results from a large, open-label European registry. ( 29349561 )
2018
5
Cluster Headache Is in Part a Disorder of the Circadian System. ( 29800013 )
2018
6
Genetic association of HCRTR2, ADH4 and CLOCK genes with cluster headache: a Chinese population-based case-control study. ( 29318394 )
2018
7
Defective functional connectivity between posterior hypothalamus and regions of the diencephalic-mesencephalic junction in chronic cluster headache. ( 29517304 )
2018
8
Treatment of Cluster Headache. ( 29720813 )
2018
9
Cluster Headache Clinical Phenotypes: Tobacco Nonexposed (Never Smoker and No Parental Secondary Smoke Exposure as a Child) versus Tobacco-Exposed: Results from the United States Cluster Headache Survey. ( 29536529 )
2018
10
Managing cluster headache with sphenopalatine ganglion stimulation: a review. ( 29497328 )
2018
11
Chronorisk in cluster headache: A tool for individualised therapy? ( 29635936 )
2018
12
Population-Based Analysis of Cluster Headache-Associated Genetic Polymorphisms. ( 29959630 )
2018
13
Diagnosis, pathophysiology, and management of cluster headache. ( 29174963 )
2018
14
Aura in Cluster Headache: A Cross-Sectional Study. ( 29933513 )
2018
15
Changes in medication cost observed in chronic cluster headache patients treated with sphenopalatine ganglion (SPG) stimulation: Analysis based on 1-year data from the Pathway R-1 Registry. ( 29921140 )
2018
16
Trigeminal Nerve Sheath Tumor Presenting as a Cluster Headache. ( 29782034 )
2018
17
Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache. ( 29850313 )
2018
18
Cluster headache. ( 29493575 )
2018
19
Noninvasive neuromodulation in migraine and cluster headache. ( 29601305 )
2018
20
Greater Occipital Nerve Injection versus Oral Steroids for Short Term Prophylaxis of Cluster Headache: A Retrospective Comparative Study. ( 29782047 )
2018
21
Cluster Headache: Epidemiology, Pathophysiology, Clinical Features, and Diagnosis. ( 29720812 )
2018
22
OnabotulinumtoxinA in the treatment of refractory chronic cluster headache. ( 29915913 )
2018
23
Cluster headache: new targets and options for treatment. ( 29623198 )
2018
24
Societal burden of cluster headache in the United States: a descriptive economic analysis. ( 29125368 )
2018
25
Systematic review of the safety and effectiveness of peripheral neurostimulation of the sphenopalatine ganglion for the treatment of refractory chronic cluster headache. ( 29338934 )
2018
26
Cluster headache is associated with unhealthy lifestyle and lifestyle-related comorbid diseases: Results from the Danish Cluster Headache Survey. ( 29933701 )
2018
27
Natural course of untreated cluster headache: A retrospective cohort study. ( 28409524 )
2018
28
Macro- and microstructural alterations of the subcortical structures in episodic cluster headache. ( 28425325 )
2018
29
A genetic CLOCK variant associated with cluster headache causing increased mRNA levels. ( 28466652 )
2018
30
Efficacy of Modified Atkins Ketogenic Diet in Chronic Cluster Headache: An Open-Label, Single-Arm, Clinical Trial. ( 29483892 )
2018
31
Cluster headache. ( 29493566 )
2018
32
Effect of Infusion of Calcitonin Gene-Related Peptide on Cluster Headache Attacks: A Randomized Clinical Trial. ( 29987329 )
2018
33
Cluster Headache and Calcitonin Gene-Related Peptide-More on Quantum Therapeutics in Headache Medicine. ( 29987331 )
2018
34
Linking Cigarette Smoking/Tobacco Exposure and Cluster Headache: A Pathogenesis Theory. ( 30011061 )
2018
35
Vitamin D deficiency in patients with cluster headache: a preliminary study. ( 30019090 )
2018
36
Editors' note: Optimal deep brain stimulation site and target connectivity for chronic cluster headache. ( 30037918 )
2018
37
Reader response: Optimal deep brain stimulation site and target connectivity for chronic cluster headache. ( 30037919 )
2018
38
Author response: Optimal deep brain stimulation site and target connectivity for chronic cluster headache. ( 30037920 )
2018
39
Cluster headache beyond the pain phase: A prospective study of 500 attacks. ( 30054443 )
2018
40
Long-Term Results of Deep Brain Stimulation of the Mamillotegmental Fasciculus in Chronic Cluster Headache. ( 30064130 )
2018
41
Epidemiologic study of cluster headache prevalence in a medium-size city in Brazil. ( 30066798 )
2018
42
Cluster Headache and Other Trigeminal Autonomic Cephalalgias. ( 30074553 )
2018
43
Correction to: Population-Based Analysis of Cluster Headache-Associated Genetic Polymorphisms. ( 30091080 )
2018
44
Cluster headache: pathophysiology, diagnosis and treatment. ( 30120560 )
2018
45
Anodal frontal tDCS for chronic cluster headache treatment: a proof-of-concept trial targeting the anterior cingulate cortex and searching for nociceptive correlates. ( 30128947 )
2018
46
Evidence mounts for anti-CGRP treatment in cluster headache. ( 30143795 )
2018
47
High-Volume Anesthetic Suboccipital Nerve Blocks for Treatment Refractory Chronic Cluster Headache With Long-Term Efficacy Data: An Observational Case Series Study. ( 30144049 )
2018
48
Health Care Utilization and Direct Costs Among Patients Diagnosed with Cluster Headache in U.S. Health Care Claims Data. ( 30156448 )
2018
49
Impact of cluster headache on employment status and job burden: a prospective cross-sectional multicenter study. ( 30178397 )
2018
50
Recurrent Reversible Cognitive Impairment in a Cluster Headache Patient: A Case Report. ( 30178567 )
2018

Variations for Cluster Headache

Expression for Cluster Headache

Search GEO for disease gene expression data for Cluster Headache.

Pathways for Cluster Headache

Pathways related to Cluster Headache according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.67 CALCA NOS1 VIP
2
Show member pathways
11.29 CACNA1A CALCA NOS1
3 10.93 CACNA1A NOS1

GO Terms for Cluster Headache

Biological processes related to Cluster Headache according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.69 CALCA PRL VIP
2 circadian rhythm GO:0007623 9.52 CLOCK PRL
3 regulation of insulin secretion GO:0050796 9.49 CACNA1A CLOCK
4 response to heat GO:0009408 9.48 CALCA NOS1
5 regulation of cytosolic calcium ion concentration GO:0051480 9.46 CALCA HCRTR2
6 feeding behavior GO:0007631 9.43 CALCA HCRTR2
7 negative regulation of blood pressure GO:0045776 9.4 CALCA NOS1
8 positive regulation of blood vessel diameter GO:0097755 9.37 CALCA VIP
9 response to pain GO:0048265 9.32 CACNA1A CALCA
10 vasodilation GO:0042311 9.26 CALCA NOS1
11 negative regulation of potassium ion transport GO:0043267 9.16 NOS1 VIP
12 multicellular organismal response to stress GO:0033555 8.96 NOS1 PRL
13 negative regulation of calcium ion transport into cytosol GO:0010523 8.62 CALCA NOS1

Molecular functions related to Cluster Headache according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CALCA PRL VIP

Sources for Cluster Headache

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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