MCID: CLS010
MIFTS: 45

Cluster Headache

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Cluster Headache

MalaCards integrated aliases for Cluster Headache:

Name: Cluster Headache 54 38 56 74

Classifications:



External Ids:

KEGG 38 H01588
ICD10 34 G44.0
UMLS 74 C0009088

Summaries for Cluster Headache

NIH Rare Diseases : 54 Cluster headaches are a form of headache notable for their extreme pain and their pattern of occurring in "clusters", usually at the same time(s) of the day for several weeks. The headaches are accompanied by autonomic symptoms, and some people experience restlessness and agitation. A cluster headache begins with severe pain strictly on one side of the head, often behind or around one eye. In some people, it may be preceded by a migraine-like "aura." The pain usually peaks over the next 5 to 10 minutes, and then continues at that intensity for up to three hours before going away. Typical attacks may strike up to eight times a day and are relatively short-lived. On average, a cluster period lasts 6 to 12 weeks. Autonomic symptoms may include: conjunctival injection (bloodshot eyes), swelling under or around the eye, excessive tearing of the eyes, drooping of the eyelid, runny nose and/or nasal congestion, and forehead and facial sweating. These symptoms generally occur only during the pain attack and are on the same side as the headache pain. Cluster headaches usually begin between the ages of 20 and 50, although they can start at any age. Males are more commonly affected than females. Treatment can be divided into acute therapy aimed at stopping symptoms once they have started and preventive therapy aimed at preventing recurrent attacks during the cluster period.

MalaCards based summary : Cluster Headache is related to migraine with or without aura 1 and migraine without aura, and has symptoms including headache and recurrent paroxysmal headache. An important gene associated with Cluster Headache is HCRTR2 (Hypocretin Receptor 2), and among its related pathways/superpathways is Signaling events mediated by PTP1B. The drugs Sumatriptan and Zolmitriptan have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and pituitary, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Wikipedia : 77 Cluster headache (CH) is a neurological disorder characterized by recurrent severe headaches on one side... more...

Related Diseases for Cluster Headache

Diseases in the Cluster Headache family:

Cluster Headache, Familial

Diseases related to Cluster Headache via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 migraine with or without aura 1 30.5 CACNA1A CALCA VIP
2 migraine without aura 29.9 CACNA1A PRL
3 cluster headache, familial 12.5
4 headache 11.9
5 paroxysmal hemicrania 11.7
6 hemicrania continua 10.9
7 familial hemiplegic migraine 10.2 CACNA1A CALCA
8 hemiplegic migraine 10.2 CACNA1A CALCA
9 wdha syndrome 10.2 CALCA VIP
10 hemiplegia 10.2 CACNA1A CALCA
11 leprosy 2 10.2 CALCA VIP
12 vasomotor rhinitis 10.2 CALCA VIP
13 sleep apnea 10.2
14 alternating hemiplegia of childhood 10.2 CACNA1A CALCA
15 pancreatic cholera 10.2 CALCA VIP
16 diffuse pulmonary fibrosis 10.2 CALCA VIP
17 carotid artery dissection 10.1
18 prolactin producing pituitary tumor 10.1 CALCA PRL
19 trigeminal neuralgia 10.1
20 ovarian cystic teratoma 10.1 CALCA PRL
21 depression 10.1
22 fibrous dysplasia 10.1 CALCA PRL
23 sinusitis 10.0
24 arteriovenous malformation 10.0
25 horner's syndrome 10.0
26 head injury 10.0
27 duodenal somatostatinoma 10.0 CALCA INS
28 plethora of newborn 10.0 CALCA INS
29 autonomic nervous system disease 10.0 CALCA INS
30 constipation 10.0 CALCA VIP
31 anisocoria 10.0
32 multiple sclerosis 10.0
33 angina pectoris 10.0
34 herpes simplex 10.0
35 inflammatory and toxic neuropathy 10.0 ADH4 INS
36 hyperprolactinemia 10.0 PRL VIP
37 postgastrectomy syndrome 9.9 INS VIP
38 impotence 9.9 PRL VIP
39 gastrinoma 9.9 INS VIP
40 myositis 9.9
41 lung cancer 9.9
42 cataract 9.9
43 thrombosis 9.9
44 migraine with aura 9.9
45 acute retrobulbar neuritis 9.9
46 neuritis 9.9
47 acute maxillary sinusitis 9.9
48 maxillary sinusitis 9.9
49 peptic ulcer disease 9.9
50 orbital plasma cell granuloma 9.9

Graphical network of the top 20 diseases related to Cluster Headache:



Diseases related to Cluster Headache

Symptoms & Phenotypes for Cluster Headache

UMLS symptoms related to Cluster Headache:


headache, recurrent paroxysmal headache

MGI Mouse Phenotypes related to Cluster Headache:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.63 CACNA1A CLOCK HCRTR2 INS PRL VIP
2 endocrine/exocrine gland MP:0005379 9.35 CACNA1A CLOCK INS PRL VIP
3 reproductive system MP:0005389 9.02 CACNA1A CLOCK INS PRL VIP

Drugs & Therapeutics for Cluster Headache

Drugs for Cluster Headache (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 146)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sumatriptan Approved, Investigational Phase 4,Phase 3,Not Applicable 103628-46-2 5358
2
Zolmitriptan Approved, Investigational Phase 4 139264-17-8 60857 441240
3
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
4
Rizatriptan Approved Phase 4 144034-80-0, 145202-66-0 5078
5
Bupivacaine Approved, Investigational Phase 4,Not Applicable,Early Phase 1 38396-39-3, 2180-92-9 2474
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
7
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
8
Triamcinolone Approved, Vet_approved Phase 4,Not Applicable 124-94-7 31307
9
Topiramate Approved Phase 4 97240-79-4 5284627
10 Serotonin Agents Phase 4,Phase 3,Phase 2
11 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2,Not Applicable
12 Serotonin 5-HT1 Receptor Agonists Phase 4,Phase 3
13 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
14 Serotonin Receptor Agonists Phase 4,Phase 3,Phase 2
15 Anti-Infective Agents Phase 4
16 Oxazolidinones Phase 4
17 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
18 Anesthetics, Local Phase 4,Phase 2,Not Applicable,Early Phase 1
19 Betamethasone Valerate Phase 4 2152-44-5
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
21 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
22 Respiratory System Agents Phase 4,Not Applicable
23 glucocorticoids Phase 4
24 Hormone Antagonists Phase 4,Phase 2
25 Betamethasone-17,21-dipropionate Phase 4
26 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Not Applicable
27 Betamethasone sodium phosphate Phase 4
28 Betamethasone benzoate Phase 4
29 Hormones Phase 4,Phase 2,Phase 3,Not Applicable
30 Anti-Asthmatic Agents Phase 4,Not Applicable
31 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
32 Antineoplastic Agents, Hormonal Phase 4,Phase 1,Phase 2
33 Autonomic Agents Phase 4,Phase 1,Phase 2,Not Applicable
34 Antiemetics Phase 4,Phase 1,Phase 2,Not Applicable
35 Gastrointestinal Agents Phase 4,Phase 1,Phase 2,Not Applicable
36 Immunologic Factors Phase 4,Phase 3
37 HIV Protease Inhibitors Phase 4,Phase 2
38
protease inhibitors Phase 4,Phase 2
39 Anticonvulsants Phase 4,Not Applicable
40 BB 1101 Phase 4
41 Triamcinolone hexacetonide Phase 4,Not Applicable
42 Immunosuppressive Agents Phase 4
43 triamcinolone acetonide Phase 4,Not Applicable
44 Triamcinolone diacetate Phase 4,Not Applicable
45 Hypoglycemic Agents Phase 4
46
Serotonin Investigational, Nutraceutical Phase 4,Phase 3,Phase 2 50-67-9 5202
47
Sodium oxybate Approved Phase 3 502-85-2 5360545
48
Verapamil Approved Phase 2, Phase 3 52-53-9 2520
49
Capsaicin Approved Phase 3,Phase 1 404-86-4 1548943
50
Acetylcholine Approved, Investigational Phase 3,Phase 1,Phase 2 51-84-3 187

Interventional clinical trials:

(show top 50) (show all 83)
# Name Status NCT ID Phase Drugs
1 Sumatriptan 4 mg Statdose in the Acute Treatment of Cluster Headache Unknown status NCT00399243 Phase 4 Sumatriptan 4mg Statdose injection
2 Efficacy and Safety of Zolmitriptan by Sublingual Administration Unknown status NCT03377257 Phase 4 zolmitriptan by sublingual administration;zolmitriptan by oral
3 GON-block in Chronic Migraine: a Randomized, Double- Blind, Placebo-controlled Study Unknown status NCT02686983 Phase 4 Betamethasone and local anesthetic
4 Rizatriptan in Acute Treatment of Migraine in Patients With Unilateral Trigeminal-autonomic Symptoms. Completed NCT00753311 Phase 4 rizatriptan or placebo
5 A Comparison of Dexamethasone and Triamcinolone for Ultrasound-guided Occipital C2 Nerve Blocks Recruiting NCT02655523 Phase 4 Triamcinolone;Dexamethasone;Normal Saline;Bupivacaine
6 A Double-Blind, Placebo-Controlled Study Examining the Use of Topiramate in the Treatment of Cluster Headache Terminated NCT00203190 Phase 4 Topiramate
7 Sodium Oxybate in Patients With Episodic and Chronic Cluster Headache Unknown status NCT02637648 Phase 3 Sodium Oxybate;Placebo
8 A Study Of Galcanezumab In Participants With Episodic Cluster Headache Completed NCT02397473 Phase 3 Galcanezumab;Placebo
9 Anodal Transcranial Direct Stimulation (tDCS) for the Treatment of Chronic Cluster Headache Completed NCT02462395 Phase 2, Phase 3
10 A Study Comparing the Efficacy and Safety of TEV-48125 (Fremanezumab) for the Prevention of Chronic Cluster Headache (CCH) Completed NCT02964338 Phase 3 Fremanezumab- A;Fremanezumab- B;Placebo
11 Cluster Headache Cortivazol Injection (CHCI) Completed NCT00804895 Phase 2, Phase 3 ALTIM, cortivazol injections;PROAMP, subcutaneous serum physiological saline;Verapamil
12 Intranasal Civamide for Episodic Cluster Headache Completed NCT00069082 Phase 3 Civamide (Zucapsaicin);Sodium Chloride
13 A Phase III Study of Civamide Nasal Solution (Zucapsaicin) for the Treatment of Episodic Cluster Headache Completed NCT00033839 Phase 3 Civamide (Zucapsaicin)
14 Study Of Sumatriptan Succinate Injection Kit In Patients With Migraine or Cluster Headache In Japan Completed NCT00356603 Phase 3 Sumatriptan Succinate
15 A Study to Evaluate the Efficacy and Safety of TEV-48125 (Fremanezumab) for the Prevention of Episodic Cluster Headache (ECH) Recruiting NCT02945046 Phase 3 Fremanezumab - A;Fremanezumab - B;Placebo
16 A Study of LY2951742 in Participants With Chronic Cluster Headache Active, not recruiting NCT02438826 Phase 3 LY2951742;Placebo
17 Occipital Nerve Stimulation in Medically Intractable Chronic Cluster Headache Active, not recruiting NCT01151631 Phase 3
18 A Study of LY2951742 (Galcanezumab) in Participants With Cluster Headache Enrolling by invitation NCT02797951 Phase 3 Galcanezumab
19 A Study to Explore the Long-Term Safety of TEV-48125 (Fremanezumab) for the Prevention of Cluster Headache Enrolling by invitation NCT03107052 Phase 3 Fremanezumab
20 Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Cluster Headache Not yet recruiting NCT03944876 Phase 3 Botulinum toxin type A;placebo
21 Civamide Nasal Solution for Cluster Headache Not yet recruiting NCT01341548 Phase 3 Civamide nasal solution 0.01%
22 Randomized Evaluation of Octreotide Versus Compazine for Emergency Department Treatment of Migraine Headache Unknown status NCT00274170 Phase 1, Phase 2 Octreotide
23 Botox Injection in Treatment of Cluster Headache Completed NCT02019017 Phase 1, Phase 2 Botulinum Toxin Type A 25 IU;Botulinum Toxin Type A 50 IU
24 Prevention and Acute Treatment of Chronic Cluster Headache Compared to Standard of Care Completed NCT01701245 Phase 2
25 Prophylactic Treatment of Episodic Cluster Headache Completed NCT00184587 Phase 2 candesartan cilexetil;placebo
26 Occipital Nerve Stimulation to Treat Chronic Headaches Completed NCT00205894 Phase 1, Phase 2
27 Lysergic Acid Diethylamide (LSD) as Treatment for Cluster Headache Recruiting NCT03781128 Phase 2 Lysergic Acid Diethylamide;Placebo
28 Botulinum Toxin Type A Block of the Otic Ganglion in Chronic Cluster Headache: Safety Issues Recruiting NCT03066635 Phase 1, Phase 2 Botulinum Toxin Type A 25 IU;Botulinum Toxin Type A 12.5 IU
29 Psilocybin-facilitated Treatment for Cocaine Use Recruiting NCT02037126 Phase 2 Psilocybin;Diphenhydramine
30 Safety and Efficacy Study of SOM230 s.c. in Cluster Headache Terminated NCT02619617 Phase 2 SOM230;Placebo
31 Pilot Study Evaluating the Use of Nasal Carbon Dioxide for the Treatment of Cluster Headache Terminated NCT02381795 Phase 2 Nasal Carbon Dioxide
32 R-Verapamil for the Prophylaxis of Episodic Cluster Headache Terminated NCT02209155 Phase 2 R-verapamil 75 mg tablet;Placebo
33 A Pilot Study of Demand Valve Oxygen Inhalation Therapy for Cluster Headache Completed NCT01298921 Phase 1 Oxygen;Oxygen
34 Psilocybin for the Treatment of Cluster Headache Recruiting NCT02981173 Phase 1 0.143 mg/kg Psilocybin;0.0143 mg/kg Psilocybin;Placebo
35 Pain Biomarker Study Active, not recruiting NCT03511846 Phase 1 Oral capsaicin;Topical capsaicin;Intranasal capsaicin;Low Flow Oxygen;High Flow Oxygen
36 Cluster Headache, Addictions and Vascular Function Unknown status NCT02640105
37 Cerebral Metabolism in Patients With Refractory Chronic Cluster Headache Treated by Occipital Nerve Stimulation Unknown status NCT02081482 Not Applicable
38 Physiotherapy Program for Cluster Headache Unknown status NCT02460003 Not Applicable
39 Baclofen in the Treatment of Muscle Cramps in Patients With Cirrhosis Unknown status NCT02221570 Not Applicable Baclofen
40 French Database of Occipital Nerves Stimulation in the Treatment of Refractory Chronic Headache Disorders Unknown status NCT01842763
41 Analysis of the Prevalence and Characteristics of Concomitant Sleep and Headache Disorders, and the Efficacy of CPAP Treatment for Headache Among Those Patients Diagnosed With Obstructive Sleep Apnea Unknown status NCT00520156
42 Inflammatory Markers Identification in Migraine Patients Unknown status NCT01618201
43 Identification of Inflammatory Markers in Migraine Patients Unknown status NCT00969995
44 Sleep in Cluster Headache: Sleep Parameters in- and Outside a Cluster Bout Completed NCT03439722
45 Circadian Rhythm and Attack-timing in Episodic Cluster Headache Patients in- and Outside of Bout: an Actigraphic Study Completed NCT02853487
46 Sleep, Circadian Rhythms and Cluster Headache Completed NCT01447641
47 Intranasal Cooling for Cluster Headache and Migraine Completed NCT01898455 Not Applicable
48 Non-invasive Neurostimulation of the Vagus Nerve for the Treatment of Cluster Headache Completed NCT01792817 Not Applicable
49 Cluster Headache and SPINK-1 Gene Completed NCT02585739 Not Applicable
50 Actigraphy and Nocturnal Heartrate Variability in Cluster Headache Patients Completed NCT03010189 Not Applicable

Search NIH Clinical Center for Cluster Headache

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Cluster Headache

Anatomical Context for Cluster Headache

MalaCards organs/tissues related to Cluster Headache:

42
Eye, Brain, Pituitary, Heart, Testes, Hypothalamus, Endothelial

Publications for Cluster Headache

Articles related to Cluster Headache:

(show top 50) (show all 1602)
# Title Authors Year
1
Pourfour du Petit Syndrome: A Rare Association With Cluster Headache. ( 30614949 )
2019
2
Development and Validation of the Cluster Headache Screening Questionnaire. ( 30618222 )
2019
3
Effectiveness of Oxygen and Other Acute Treatments for Cluster Headache: Results From the Cluster Headache Questionnaire, an International Survey. ( 30632614 )
2019
4
Analysis of HCRTR2 Gene Variants and Cluster Headache in Sweden. ( 30652302 )
2019
5
Alterations of structural connectivity in episodic cluster headache: A graph theoretical analysis. ( 30655236 )
2019
6
Update on the pathophysiology of cluster headache: imaging and neuropeptide studies. ( 30655693 )
2019
7
Device for Cluster Headache. ( 30667491 )
2019
8
Changes in grey matter volume and functional connectivity in cluster headache versus migraine. ( 30762158 )
2019
9
Cluster headache in relation to different age groups. ( 30796624 )
2019
10
Anti-CGRP in cluster headache therapy. ( 30820761 )
2019
11
Non-invasive neuromodulation for migraine and cluster headache: a systematic review of clinical trials. ( 30824632 )
2019
12
The role of neurotransmitters and neuromodulators in the pathogenesis of cluster headache: a review. ( 30825019 )
2019
13
Deep brain stimulation modulates hypothalamic-brainstem fibers in cluster headache: case report. ( 30835692 )
2019
14
The influence of lifestyle and gender on cluster headache. ( 30844861 )
2019
15
Calcitonin-gene related peptide and disease activity in cluster headache. ( 30854880 )
2019
16
Field testing the diagnostic criteria of cluster headache in the third edition of the International Classification of Headache Disorders: A cross-sectional multicentre study. ( 30857402 )
2019
17
Hemiplegic cluster headache: A case report and review of the literature. ( 30860139 )
2019
18
Endogenous Neurostimulation and Physiotherapy in Cluster Headache: A Clinical Case. ( 30870974 )
2019
19
Cluster headache: crosspoint between otologists and neurologists-treatment of the sphenopalatine ganglion and systematic review. ( 30877613 )
2019
20
Emerging treatments for cluster headache: hopes and disappointments. ( 30893102 )
2019
21
Ventral tegmental area deep brain stimulation for chronic cluster headache: Effects on cognition, mood, pain report behaviour and quality of life. ( 30897944 )
2019
22
Multicentre, prospective, randomised, controlled, blinded-endpoint study to evaluate the efficacy and safety of pterygopalatine ganglion pulsed radiofrequency treatment for cluster headache: study protocol. ( 30904875 )
2019
23
Some aspects on the pathophysiology of migraine and a review of device therapies for migraine and cluster headache. ( 30906962 )
2019
24
Clinical features of cluster headache in relation to age of onset: results from a retrospective study of a large case series. ( 30906965 )
2019
25
Behavioral and psychological aspects of cluster headache: an overview. ( 30906966 )
2019
26
The spectrum of cluster headache: A case report of 4600 attacks. ( 30913909 )
2019
27
Genetics of cluster headache. ( 30917683 )
2019
28
Cluster headache: insights from resting-state functional magnetic resonance imaging. ( 30941629 )
2019
29
Cluster Headache in Subjects With Substance Use Disorder: A Case Series and a Review of the Literature. ( 30957220 )
2019
30
Hyperalgesia and Central Sensitization Signs in Patients with Cluster Headache: A Cross-Sectional Study. ( 30958885 )
2019
31
Increased suicidality in patients with cluster headache. ( 31018651 )
2019
32
Associated Factors and Clinical Implication of Cutaneous Allodynia in Patients with Cluster Headache: A Prospective Multicentre Study. ( 31024044 )
2019
33
Zonisamide for Cluster Headache Prophylaxis: A Case Series. ( 31038740 )
2019
34
More precise phenotyping of cluster headache using prospective attack reports. ( 31059165 )
2019
35
Greater Occipital Nerve Infiltration During Pregnancy in Cluster Headache: A Case Report. ( 31106401 )
2019
36
A case of remitting hemicrania continua with seasonal variation and clustering: a diagnostic confusion with cluster headache. ( 31110069 )
2019
37
CGRP, a target for preventive therapy in migraine and cluster headache: Systematic review of clinical data. ( 29110503 )
2019
38
Cluster headache is associated with unhealthy lifestyle and lifestyle-related comorbid diseases: Results from the Danish Cluster Headache Survey. ( 29933701 )
2019
39
Cluster headache: pathophysiology, diagnosis and treatment. ( 30120560 )
2019
40
High-Volume Anesthetic Suboccipital Nerve Blocks for Treatment Refractory Chronic Cluster Headache With Long-Term Efficacy Data: An Observational Case Series Study. ( 30144049 )
2019
41
Increased use of illicit drugs in a Dutch cluster headache population. ( 30290701 )
2019
42
Neurostimulation for the treatment of chronic migraine and cluster headache. ( 30291633 )
2019
43
Disturbed sleep in cluster headache is not the result of transient processes associated with the cluster period. ( 30300455 )
2019
44
Systematic literature review on the delays in the diagnosis and misdiagnosis of cluster headache. ( 30306398 )
2019
45
Efficacy of Sphenopalatine Ganglion Radiofrequency in Refractory Chronic Cluster Headache. ( 30315985 )
2019
46
Sleep in cluster headache revisited: Results from a controlled actigraphic study. ( 30470143 )
2019
47
Cognitive Performance in Episodic Cluster Headache. ( 30534998 )
2019
48
Vidian Neurectomy for Management of Chronic Cluster Headache. ( 30535031 )
2019
49
Repetitive transcranial magnetic stimulation in cluster headache. ( 30573324 )
2018
50
Sensory function in cluster headache: an observational study comparing the symptomatic and asymptomatic sides. ( 30573960 )
2018

Variations for Cluster Headache

Expression for Cluster Headache

Search GEO for disease gene expression data for Cluster Headache.

Pathways for Cluster Headache

Pathways related to Cluster Headache according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.32 INS PRL

GO Terms for Cluster Headache

Cellular components related to Cluster Headache according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.62 INS PRL

Biological processes related to Cluster Headache according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.76 CALCA HCRTR2 INS VIP
2 regulation of insulin secretion GO:0050796 9.43 CACNA1A CLOCK
3 cellular protein metabolic process GO:0044267 9.43 CALCA INS PRL
4 regulation of protein localization GO:0032880 9.4 INS VIP
5 regulation of cytosolic calcium ion concentration GO:0051480 9.37 CALCA HCRTR2
6 regulation of signaling receptor activity GO:0010469 9.26 CALCA INS PRL VIP
7 feeding behavior GO:0007631 9.02 HCRTR2
8 response to pain GO:0048265 8.85 CACNA1A
9 positive regulation of blood vessel diameter GO:0097755 8.8 CALCA INS VIP

Molecular functions related to Cluster Headache according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 CALCA INS PRL VIP

Sources for Cluster Headache

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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