MCID: CLS010
MIFTS: 46

Cluster Headache

Categories: Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Cluster Headache

MalaCards integrated aliases for Cluster Headache:

Name: Cluster Headache 54 38 56 74

Classifications:



External Ids:

KEGG 38 H01588
ICD10 34 G44.0
UMLS 74 C0009088

Summaries for Cluster Headache

NIH Rare Diseases : 54 Cluster headaches are a form of headache notable for their extreme pain and their pattern of occurring in "clusters", usually at the same time(s) of the day for several weeks. The headaches are accompanied by autonomic symptoms, and some people experience restlessness and agitation. A cluster headache begins with severe pain strictly on one side of the head, often behind or around one eye. In some people, it may be preceded by a migraine-like "aura." The pain usually peaks over the next 5 to 10 minutes, and then continues at that intensity for up to three hours before going away. Typical attacks may strike up to eight times a day and are relatively short-lived. On average, a cluster period lasts 6 to 12 weeks. Autonomic symptoms may include: conjunctival injection (bloodshot eyes), swelling under or around the eye, excessive tearing of the eyes, drooping of the eyelid, runny nose and/or nasal congestion, and forehead and facial sweating. These symptoms generally occur only during the pain attack and are on the same side as the headache pain. Cluster headaches usually begin between the ages of 20 and 50, although they can start at any age. Males are more commonly affected than females. Treatment can be divided into acute therapy aimed at stopping symptoms once they have started and preventive therapy aimed at preventing recurrent attacks during the cluster period.

MalaCards based summary : Cluster Headache is related to migraine with or without aura 1 and migraine without aura, and has symptoms including headache and recurrent paroxysmal headache. An important gene associated with Cluster Headache is HCRTR2 (Hypocretin Receptor 2), and among its related pathways/superpathways is Signaling events mediated by PTP1B. The drugs Sumatriptan and Betamethasone have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Wikipedia : 77 Cluster headache (CH) is a neurological disorder characterized by recurrent severe headaches on one side... more...

Related Diseases for Cluster Headache

Diseases in the Cluster Headache family:

Cluster Headache, Familial

Diseases related to Cluster Headache via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 migraine with or without aura 1 30.3 CACNA1A CALCA VIP
2 migraine without aura 29.9 CACNA1A PRL
3 cluster headache, familial 12.5
4 headache 11.8
5 paroxysmal hemicrania 11.6
6 hemicrania continua 10.9
7 familial hemiplegic migraine 10.2 CACNA1A CALCA
8 hemiplegic migraine 10.2 CACNA1A CALCA
9 wdha syndrome 10.2 CALCA VIP
10 hemiplegia 10.2 CACNA1A CALCA
11 leprosy 2 10.2 CALCA VIP
12 vasomotor rhinitis 10.2 CALCA VIP
13 sleep apnea 10.2
14 alternating hemiplegia of childhood 10.2 CACNA1A CALCA
15 pancreatic cholera 10.2 CALCA VIP
16 diffuse pulmonary fibrosis 10.2 CALCA VIP
17 carotid artery dissection 10.1
18 prolactin producing pituitary tumor 10.1 CALCA PRL
19 trigeminal neuralgia 10.1
20 ovarian cystic teratoma 10.1 CALCA PRL
21 depression 10.1
22 fibrous dysplasia 10.1 CALCA PRL
23 sinusitis 10.0
24 arteriovenous malformation 10.0
25 horner's syndrome 10.0
26 duodenal somatostatinoma 10.0 CALCA INS
27 plethora of newborn 10.0 CALCA INS
28 autonomic nervous system disease 10.0 CALCA INS
29 constipation 10.0 CALCA VIP
30 anisocoria 10.0
31 multiple sclerosis 10.0
32 angina pectoris 10.0
33 herpes simplex 10.0
34 head injury 10.0
35 pauci-immune glomerulonephritis without anca 10.0
36 hyperprolactinemia 9.9 PRL VIP
37 inflammatory and toxic neuropathy 9.9 ADH4 INS
38 postgastrectomy syndrome 9.9 INS VIP
39 impotence 9.9 PRL VIP
40 gastrinoma 9.9 INS VIP
41 myositis 9.9
42 lung cancer 9.9
43 cataract 9.9
44 thrombosis 9.9
45 migraine with aura 9.9
46 neuritis 9.9
47 acute maxillary sinusitis 9.9
48 maxillary sinusitis 9.9
49 peptic ulcer disease 9.9
50 orbital plasma cell granuloma 9.9

Graphical network of the top 20 diseases related to Cluster Headache:



Diseases related to Cluster Headache

Symptoms & Phenotypes for Cluster Headache

UMLS symptoms related to Cluster Headache:


headache, recurrent paroxysmal headache

MGI Mouse Phenotypes related to Cluster Headache:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.63 CACNA1A CLOCK HCRTR2 INS PRL VIP
2 endocrine/exocrine gland MP:0005379 9.35 CACNA1A CLOCK INS PRL VIP
3 reproductive system MP:0005389 9.02 CACNA1A CLOCK INS PRL VIP

Drugs & Therapeutics for Cluster Headache

Drugs for Cluster Headache (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 146)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sumatriptan Approved, Investigational Phase 4,Phase 3,Not Applicable 103628-46-2 5358
2
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
3
Rizatriptan Approved Phase 4 145202-66-0, 144034-80-0 5078
4
Bupivacaine Approved, Investigational Phase 4,Not Applicable,Early Phase 1 2180-92-9, 38396-39-3 2474
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
6
Triamcinolone Approved, Vet_approved Phase 4,Not Applicable 124-94-7 31307
7
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
8
Zolmitriptan Approved, Investigational Phase 4 139264-17-8 441240 60857
9
Topiramate Approved Phase 4 97240-79-4 5284627
10 Serotonin 5-HT1 Receptor Agonists Phase 4,Phase 3
11 Serotonin Receptor Agonists Phase 4,Phase 3,Phase 2
12 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2,Not Applicable
13 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
14 Serotonin Agents Phase 4,Phase 3,Phase 2
15 Betamethasone benzoate Phase 4
16 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
17 Anesthetics, Local Phase 4,Phase 2,Not Applicable,Early Phase 1
18 Betamethasone sodium phosphate Phase 4
19 Hormones Phase 4,Phase 2,Phase 3,Not Applicable
20 Anti-Asthmatic Agents Phase 4,Not Applicable
21 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Not Applicable
22 Betamethasone-17,21-dipropionate Phase 4
23 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
24 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
25 Betamethasone Valerate Phase 4 2152-44-5
26 Hormone Antagonists Phase 4,Phase 2
27 Respiratory System Agents Phase 4,Not Applicable
28 glucocorticoids Phase 4
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
30 Autonomic Agents Phase 4,Phase 1,Phase 2,Not Applicable
31 Antineoplastic Agents, Hormonal Phase 4,Phase 1,Phase 2
32 Antiemetics Phase 4,Phase 1,Phase 2,Not Applicable
33 Gastrointestinal Agents Phase 4,Phase 1,Phase 2,Not Applicable
34
protease inhibitors Phase 4,Phase 2
35 HIV Protease Inhibitors Phase 4,Phase 2
36 Immunologic Factors Phase 4,Phase 3
37 Anticonvulsants Phase 4,Not Applicable
38 Immunosuppressive Agents Phase 4
39 BB 1101 Phase 4
40 Triamcinolone hexacetonide Phase 4,Not Applicable
41 Triamcinolone diacetate Phase 4,Not Applicable
42 triamcinolone acetonide Phase 4,Not Applicable
43 Oxazolidinones Phase 4
44 Anti-Infective Agents Phase 4
45 Hypoglycemic Agents Phase 4
46
Serotonin Investigational, Nutraceutical Phase 4,Phase 3,Phase 2 50-67-9 5202
47
Sodium oxybate Approved Phase 3 502-85-2 5360545
48
Verapamil Approved Phase 2, Phase 3 52-53-9 2520
49
Capsaicin Approved Phase 3,Phase 1 404-86-4 1548943
50
Calcium Approved, Nutraceutical Phase 2, Phase 3,Not Applicable 7440-70-2 271

Interventional clinical trials:

(show top 50) (show all 82)
# Name Status NCT ID Phase Drugs
1 Sumatriptan 4 mg Statdose in the Acute Treatment of Cluster Headache Unknown status NCT00399243 Phase 4 Sumatriptan 4mg Statdose injection
2 GON-block in Chronic Migraine: a Randomized, Double- Blind, Placebo-controlled Study Unknown status NCT02686983 Phase 4 Betamethasone and local anesthetic
3 Rizatriptan in Acute Treatment of Migraine in Patients With Unilateral Trigeminal-autonomic Symptoms. Completed NCT00753311 Phase 4 rizatriptan or placebo
4 A Comparison of Dexamethasone and Triamcinolone for Ultrasound-guided Occipital C2 Nerve Blocks Recruiting NCT02655523 Phase 4 Triamcinolone;Dexamethasone;Normal Saline;Bupivacaine
5 Efficacy and Safety of Zolmitriptan by Sublingual Administration Not yet recruiting NCT03377257 Phase 4 zolmitriptan by sublingual administration;zolmitriptan by oral
6 A Double-Blind, Placebo-Controlled Study Examining the Use of Topiramate in the Treatment of Cluster Headache Terminated NCT00203190 Phase 4 Topiramate
7 Sodium Oxybate in Patients With Episodic and Chronic Cluster Headache Unknown status NCT02637648 Phase 3 Sodium Oxybate;Placebo
8 A Study Of Galcanezumab In Participants With Episodic Cluster Headache Completed NCT02397473 Phase 3 Galcanezumab;Placebo
9 Anodal Transcranial Direct Stimulation (tDCS) for the Treatment of Chronic Cluster Headache Completed NCT02462395 Phase 2, Phase 3
10 A Study Comparing the Efficacy and Safety of TEV-48125 (Fremanezumab) for the Prevention of Chronic Cluster Headache (CCH) Completed NCT02964338 Phase 3 Fremanezumab- A;Fremanezumab- B;Placebo
11 Cluster Headache Cortivazol Injection (CHCI) Completed NCT00804895 Phase 2, Phase 3 ALTIM, cortivazol injections;PROAMP, subcutaneous serum physiological saline;Verapamil
12 Intranasal Civamide for Episodic Cluster Headache Completed NCT00069082 Phase 3 Civamide (Zucapsaicin);Sodium Chloride
13 A Phase III Study of Civamide Nasal Solution (Zucapsaicin) for the Treatment of Episodic Cluster Headache Completed NCT00033839 Phase 3 Civamide (Zucapsaicin)
14 Study Of Sumatriptan Succinate Injection Kit In Patients With Migraine or Cluster Headache In Japan Completed NCT00356603 Phase 3 Sumatriptan Succinate
15 A Study to Evaluate the Efficacy and Safety of TEV-48125 (Fremanezumab) for the Prevention of Episodic Cluster Headache (ECH) Recruiting NCT02945046 Phase 3 Fremanezumab - A;Fremanezumab - B;Placebo
16 A Study of LY2951742 in Participants With Chronic Cluster Headache Active, not recruiting NCT02438826 Phase 3 LY2951742;Placebo
17 Occipital Nerve Stimulation in Medically Intractable Chronic Cluster Headache Active, not recruiting NCT01151631 Phase 3
18 A Study of LY2951742 (Galcanezumab) in Participants With Cluster Headache Enrolling by invitation NCT02797951 Phase 3 Galcanezumab
19 A Study to Explore the Long-Term Safety of TEV-48125 (Fremanezumab) for the Prevention of Cluster Headache Enrolling by invitation NCT03107052 Phase 3 Fremanezumab
20 Civamide Nasal Solution for Cluster Headache Not yet recruiting NCT01341548 Phase 3 Civamide nasal solution 0.01%
21 Randomized Evaluation of Octreotide Versus Compazine for Emergency Department Treatment of Migraine Headache Unknown status NCT00274170 Phase 1, Phase 2 Octreotide
22 Botox Injection in Treatment of Cluster Headache Completed NCT02019017 Phase 1, Phase 2 Botulinum Toxin Type A 25 IU;Botulinum Toxin Type A 50 IU
23 Prevention and Acute Treatment of Chronic Cluster Headache Compared to Standard of Care Completed NCT01701245 Phase 2
24 Prophylactic Treatment of Episodic Cluster Headache Completed NCT00184587 Phase 2 candesartan cilexetil;placebo
25 Occipital Nerve Stimulation to Treat Chronic Headaches Completed NCT00205894 Phase 1, Phase 2
26 Lysergic Acid Diethylamide (LSD) as Treatment for Cluster Headache Recruiting NCT03781128 Phase 2 Lysergic Acid Diethylamide;Placebo
27 Botulinum Toxin Type A Block of the Otic Ganglion in Chronic Cluster Headache: Safety Issues Recruiting NCT03066635 Phase 1, Phase 2 Botulinum Toxin Type A 25 IU;Botulinum Toxin Type A 12.5 IU
28 Psilocybin-facilitated Treatment for Cocaine Use Recruiting NCT02037126 Phase 2 Psilocybin;Diphenhydramine
29 Safety and Efficacy Study of SOM230 s.c. in Cluster Headache Terminated NCT02619617 Phase 2 SOM230;Placebo
30 Pilot Study Evaluating the Use of Nasal Carbon Dioxide for the Treatment of Cluster Headache Terminated NCT02381795 Phase 2 Nasal Carbon Dioxide
31 R-Verapamil for the Prophylaxis of Episodic Cluster Headache Terminated NCT02209155 Phase 2 R-verapamil 75 mg tablet;Placebo
32 A Pilot Study of Demand Valve Oxygen Inhalation Therapy for Cluster Headache Unknown status NCT01298921 Phase 1 Oxygen;Oxygen
33 Psilocybin for the Treatment of Cluster Headache Recruiting NCT02981173 Phase 1 0.143 mg/kg Psilocybin;0.0143 mg/kg Psilocybin;Placebo
34 Pain Biomarker Study Active, not recruiting NCT03511846 Phase 1 Oral capsaicin;Topical capsaicin;Intranasal capsaicin;Low Flow Oxygen;High Flow Oxygen
35 Cluster Headache, Addictions and Vascular Function Unknown status NCT02640105
36 Cerebral Metabolism in Patients With Refractory Chronic Cluster Headache Treated by Occipital Nerve Stimulation Unknown status NCT02081482 Not Applicable
37 Physiotherapy Program for Cluster Headache Unknown status NCT02460003 Not Applicable
38 Baclofen in the Treatment of Muscle Cramps in Patients With Cirrhosis Unknown status NCT02221570 Not Applicable Baclofen
39 French Database of Occipital Nerves Stimulation in the Treatment of Refractory Chronic Headache Disorders Unknown status NCT01842763
40 Analysis of the Prevalence and Characteristics of Concomitant Sleep and Headache Disorders, and the Efficacy of CPAP Treatment for Headache Among Those Patients Diagnosed With Obstructive Sleep Apnea Unknown status NCT00520156
41 Inflammatory Markers Identification in Migraine Patients Unknown status NCT01618201
42 Identification of Inflammatory Markers in Migraine Patients Unknown status NCT00969995
43 Sleep in Cluster Headache: Sleep Parameters in- and Outside a Cluster Bout Completed NCT03439722
44 Circadian Rhythm and Attack-timing in Episodic Cluster Headache Patients in- and Outside of Bout: an Actigraphic Study Completed NCT02853487
45 Sleep, Circadian Rhythms and Cluster Headache Completed NCT01447641
46 Intranasal Cooling for Cluster Headache and Migraine Completed NCT01898455 Not Applicable
47 Non-invasive Neurostimulation of the Vagus Nerve for the Treatment of Cluster Headache Completed NCT01792817 Not Applicable
48 Cluster Headache and SPINK-1 Gene Completed NCT02585739 Not Applicable
49 Actigraphy and Nocturnal Heartrate Variability in Cluster Headache Patients Completed NCT03010189 Not Applicable
50 Sphenopalatine Ganglion Stimulation for the Acute Treatment of Cluster Headache Completed NCT01255813 Not Applicable

Search NIH Clinical Center for Cluster Headache

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Cluster Headache

Anatomical Context for Cluster Headache

MalaCards organs/tissues related to Cluster Headache:

42
Eye, Brain, Testes, Hypothalamus, Heart, Pituitary, Endothelial

Publications for Cluster Headache

Articles related to Cluster Headache:

(show top 50) (show all 1591)
# Title Authors Year
1
Neurostimulation for the treatment of chronic migraine and cluster headache. ( 30291633 )
2019
2
Systematic literature review on the delays in the diagnosis and misdiagnosis of cluster headache. ( 30306398 )
2019
3
Repetitive transcranial magnetic stimulation in cluster headache. ( 30573324 )
2019
4
Pourfour du Petit Syndrome: A Rare Association With Cluster Headache. ( 30614949 )
2019
5
Development and Validation of the Cluster Headache Screening Questionnaire. ( 30618222 )
2019
6
Effectiveness of Oxygen and Other Acute Treatments for Cluster Headache: Results From the Cluster Headache Questionnaire, an International Survey. ( 30632614 )
2019
7
Analysis of HCRTR2 Gene Variants and Cluster Headache in Sweden. ( 30652302 )
2019
8
Alterations of structural connectivity in episodic cluster headache: A graph theoretical analysis. ( 30655236 )
2019
9
Update on the pathophysiology of cluster headache: imaging and neuropeptide studies. ( 30655693 )
2019
10
Device for Cluster Headache. ( 30667491 )
2019
11
Changes in grey matter volume and functional connectivity in cluster headache versus migraine. ( 30762158 )
2019
12
Cluster headache in relation to different age groups. ( 30796624 )
2019
13
Anti-CGRP in cluster headache therapy. ( 30820761 )
2019
14
Non-invasive neuromodulation for migraine and cluster headache: a systematic review of clinical trials. ( 30824632 )
2019
15
The role of neurotransmitters and neuromodulators in the pathogenesis of cluster headache: a review. ( 30825019 )
2019
16
Deep brain stimulation modulates hypothalamic-brainstem fibers in cluster headache: case report. ( 30835692 )
2019
17
The influence of lifestyle and gender on cluster headache. ( 30844861 )
2019
18
Calcitonin-gene related peptide and disease activity in cluster headache. ( 30854880 )
2019
19
Field testing the diagnostic criteria of cluster headache in the third edition of the International Classification of Headache Disorders: A cross-sectional multicentre study. ( 30857402 )
2019
20
Hemiplegic cluster headache: A case report and review of the literature. ( 30860139 )
2019
21
Endogenous Neurostimulation and Physiotherapy in Cluster Headache: A Clinical Case. ( 30870974 )
2019
22
Cluster headache: crosspoint between otologists and neurologists-treatment of the sphenopalatine ganglion and systematic review. ( 30877613 )
2019
23
Emerging treatments for cluster headache: hopes and disappointments. ( 30893102 )
2019
24
Ventral tegmental area deep brain stimulation for chronic cluster headache: Effects on cognition, mood, pain report behaviour and quality of life. ( 30897944 )
2019
25
Multicentre, prospective, randomised, controlled, blinded-endpoint study to evaluate the efficacy and safety of pterygopalatine ganglion pulsed radiofrequency treatment for cluster headache: study protocol. ( 30904875 )
2019
26
Some aspects on the pathophysiology of migraine and a review of device therapies for migraine and cluster headache. ( 30906962 )
2019
27
Clinical features of cluster headache in relation to age of onset: results from a retrospective study of a large case series. ( 30906965 )
2019
28
Behavioral and psychological aspects of cluster headache: an overview. ( 30906966 )
2019
29
The spectrum of cluster headache: A case report of 4600 attacks. ( 30913909 )
2019
30
High dosage of methylprednisolone in cluster headache. ( 29904864 )
2018
31
If you want to understand what it really means to live with cluster headache, imagine... fostering empathy through European patients' own stories of their experiences. ( 29633698 )
2018
32
Sphenopalatine ganglion stimulation for cluster headache, results from a large, open-label European registry. ( 29349561 )
2018
33
Cluster Headache Is in Part a Disorder of the Circadian System. ( 29800013 )
2018
34
Genetic association of HCRTR2, ADH4 and CLOCK genes with cluster headache: a Chinese population-based case-control study. ( 29318394 )
2018
35
Defective functional connectivity between posterior hypothalamus and regions of the diencephalic-mesencephalic junction in chronic cluster headache. ( 29517304 )
2018
36
Treatment of Cluster Headache. ( 29720813 )
2018
37
Cluster Headache Clinical Phenotypes: Tobacco Nonexposed (Never Smoker and No Parental Secondary Smoke Exposure as a Child) versus Tobacco-Exposed: Results from the United States Cluster Headache Survey. ( 29536529 )
2018
38
Managing cluster headache with sphenopalatine ganglion stimulation: a review. ( 29497328 )
2018
39
Chronorisk in cluster headache: A tool for individualised therapy? ( 29635936 )
2018
40
Population-Based Analysis of Cluster Headache-Associated Genetic Polymorphisms. ( 29959630 )
2018
41
Diagnosis, pathophysiology, and management of cluster headache. ( 29174963 )
2018
42
Aura in Cluster Headache: A Cross-Sectional Study. ( 29933513 )
2018
43
Changes in medication cost observed in chronic cluster headache patients treated with sphenopalatine ganglion (SPG) stimulation: Analysis based on 1-year data from the Pathway R-1 Registry. ( 29921140 )
2018
44
Trigeminal Nerve Sheath Tumor Presenting as a Cluster Headache. ( 29782034 )
2018
45
Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache. ( 29850313 )
2018
46
Cluster headache. ( 29493575 )
2018
47
Noninvasive neuromodulation in migraine and cluster headache. ( 29601305 )
2018
48
Greater Occipital Nerve Injection versus Oral Steroids for Short Term Prophylaxis of Cluster Headache: A Retrospective Comparative Study. ( 29782047 )
2018
49
Cluster Headache: Epidemiology, Pathophysiology, Clinical Features, and Diagnosis. ( 29720812 )
2018
50
OnabotulinumtoxinA in the treatment of refractory chronic cluster headache. ( 29915913 )
2018

Variations for Cluster Headache

Expression for Cluster Headache

Search GEO for disease gene expression data for Cluster Headache.

Pathways for Cluster Headache

Pathways related to Cluster Headache according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.32 INS PRL

GO Terms for Cluster Headache

Cellular components related to Cluster Headache according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.62 INS PRL

Biological processes related to Cluster Headache according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.76 CALCA HCRTR2 INS VIP
2 regulation of insulin secretion GO:0050796 9.43 CACNA1A CLOCK
3 cellular protein metabolic process GO:0044267 9.43 CALCA INS PRL
4 regulation of protein localization GO:0032880 9.4 INS VIP
5 regulation of cytosolic calcium ion concentration GO:0051480 9.37 CALCA HCRTR2
6 feeding behavior GO:0007631 9.32 CALCA HCRTR2
7 regulation of signaling receptor activity GO:0010469 9.26 CALCA INS PRL VIP
8 response to pain GO:0048265 9.16 CACNA1A CALCA
9 positive regulation of blood vessel diameter GO:0097755 8.8 CALCA INS VIP

Molecular functions related to Cluster Headache according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 CALCA INS PRL VIP

Sources for Cluster Headache

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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