MCID: CLS010
MIFTS: 46

Cluster Headache

Categories: Rare diseases, Neuronal diseases, Genetic diseases

Aliases & Classifications for Cluster Headache

MalaCards integrated aliases for Cluster Headache:

Name: Cluster Headache 53 37 55 73

Classifications:



External Ids:

KEGG 37 H01588
ICD10 33 G44.0
UMLS 73 C0009088

Summaries for Cluster Headache

NIH Rare Diseases : 53 Cluster headaches are a form of headache notable for their extreme pain and their pattern of occurring in "clusters", usually at the same time(s) of the day for several weeks. The headaches are accompanied by autonomic symptoms, and some people experience restlessness and agitation. A cluster headache begins with severe pain strictly on one side of the head, often behind or around one eye. In some people, it may be preceded by a migraine-like "aura." The pain usually peaks over the next 5 to 10 minutes, and then continues at that intensity for up to three hours before going away. Typical attacks may strike up to eight times a day and are relatively short-lived. On average, a cluster period lasts 6 to 12 weeks. Autonomic symptoms may include: conjunctival injection (bloodshot eyes), swelling under or around the eye, excessive tearing of the eyes, drooping of the eyelid, runny nose and/or nasal congestion, and forehead and facial sweating. These symptoms generally occur only during the pain attack and are on the same side as the headache pain. Cluster headaches usually begin between the ages of 20 and 50, although they can start at any age. Males are more commonly affected than females. Treatment can be divided into acute therapy aimed at stopping symptoms once they have started and preventive therapy aimed at preventing recurrent attacks during the cluster period.

MalaCards based summary : Cluster Headache is related to sleep disorder and restless legs syndrome, and has symptoms including headache and recurrent paroxysmal headache. An important gene associated with Cluster Headache is HCRTR2 (Hypocretin Receptor 2), and among its related pathways/superpathways are Myometrial Relaxation and Contraction Pathways and Neuroscience. The drugs Betamethasone and Sumatriptan have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and hypothalamus, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Wikipedia : 76 Cluster headache (CH) is a neurological disorder characterized by recurrent, severe headaches on one... more...

Related Diseases for Cluster Headache

Diseases in the Cluster Headache family:

Cluster Headache, Familial

Diseases related to Cluster Headache via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 sleep disorder 29.4 HCRT HCRTR2
2 restless legs syndrome 27.2 CACNA1A CLOCK HCRT NOS1
3 cluster headache, familial 12.3
4 headache 11.6
5 paroxysmal hemicrania 11.5
6 hemicrania continua 10.7
7 wdha syndrome 10.3 CALCA VIP
8 familial hemiplegic migraine 10.3 CACNA1A CALCA
9 leprosy 2 10.3 CALCA VIP
10 hemiplegic migraine 10.2 CACNA1A CALCA
11 vasomotor rhinitis 10.2 CALCA VIP
12 pancreatic cholera 10.2 CALCA VIP
13 somatostatinoma 10.2 CALCA VIP
14 rohhad 10.2 HCRT HCRTR2
15 diffuse pulmonary fibrosis 10.2 CALCA VIP
16 islet cell tumor 10.2 CALCA VIP
17 hemiplegia 10.1 CACNA1A CALCA
18 alternating hemiplegia of childhood 10.1 CACNA1A CALCA
19 carotid artery dissection 10.0
20 sleep apnea 10.0
21 cervicitis 10.0
22 apnea, obstructive sleep 9.9
23 cerebritis 9.9
24 depression 9.9
25 acute thyroiditis 9.9 CALCA NOS1
26 advanced sleep phase syndrome 9.9 CLOCK HCRT
27 horner's syndrome 9.9
28 multiple sclerosis 9.8
29 aging 9.8
30 cataract 9.8
31 sinusitis 9.8
32 migraine with aura 9.8
33 migraine without aura 9.8
34 acute maxillary sinusitis 9.8
35 maxillary sinusitis 9.8
36 retinitis 9.8
37 meningitis 9.8
38 glioblastoma 9.8
39 harlequin syndrome 9.8
40 aneurysm 9.8
41 head injury 9.8
42 hemifacial spasm 9.8
43 endocrine gland cancer 9.8 CALCA VIP
44 urticaria pigmentosa 9.8 CALCA IL2RA VIP
45 glioma susceptibility 1 9.6
46 parkinson disease, late-onset 9.6
47 thrombophilia due to thrombin defect 9.6
48 trigeminal neuralgia 9.6
49 lung cancer 9.6
50 factor xii deficiency 9.6

Graphical network of the top 20 diseases related to Cluster Headache:



Diseases related to Cluster Headache

Symptoms & Phenotypes for Cluster Headache

UMLS symptoms related to Cluster Headache:


headache, recurrent paroxysmal headache

MGI Mouse Phenotypes related to Cluster Headache:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.63 CACNA1A CLOCK HCRT HCRTR2 NOS1 VIP
2 endocrine/exocrine gland MP:0005379 9.35 CACNA1A CLOCK IL2RA NOS1 VIP
3 respiratory system MP:0005388 9.02 CACNA1A HCRT IL2RA NOS1 VIP

Drugs & Therapeutics for Cluster Headache

Drugs for Cluster Headache (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 134)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
2
Sumatriptan Approved, Investigational Phase 4,Phase 3,Not Applicable 103628-46-2 5358
3
Rizatriptan Approved Phase 4 145202-66-0, 144034-80-0 5078
4
Bupivacaine Approved, Investigational Phase 4,Not Applicable,Early Phase 1 2180-92-9, 38396-39-3 2474
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
6
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
7
Zolmitriptan Approved, Investigational Phase 4 139264-17-8 441240 60857
8
Topiramate Approved Phase 4 97240-79-4 5284627
9 Betamethasone Valerate Phase 4 2152-44-5
10 glucocorticoids Phase 4
11 Respiratory System Agents Phase 4,Not Applicable
12 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
13 Serotonin 5-HT1 Receptor Agonists Phase 4,Phase 3
14 Serotonin Agents Phase 4,Phase 3
15 Gastrointestinal Agents Phase 4,Phase 1,Phase 2,Not Applicable
16 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
17 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
18 Hormone Antagonists Phase 4,Phase 2
19 Anesthetics, Local Phase 4,Phase 2,Not Applicable,Early Phase 1
20 Hormones Phase 4,Phase 2
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
22 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2,Not Applicable
23 Anti-Asthmatic Agents Phase 4,Not Applicable
24 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
25 Antiemetics Phase 4,Phase 1,Phase 2,Not Applicable
26 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Not Applicable
27 Autonomic Agents Phase 4,Phase 1,Phase 2,Not Applicable
28 Betamethasone benzoate Phase 4
29 Betamethasone sodium phosphate Phase 4
30 Betamethasone-17,21-dipropionate Phase 4
31 Antineoplastic Agents, Hormonal Phase 4,Phase 1,Phase 2
32
protease inhibitors Phase 4,Phase 2
33 HIV Protease Inhibitors Phase 4,Phase 2
34 Anticonvulsants Phase 4,Not Applicable
35 triamcinolone acetonide Phase 4
36 Dexamethasone acetate Phase 4 1177-87-3
37 Triamcinolone diacetate Phase 4
38 Triamcinolone hexacetonide Phase 4
39 Immunosuppressive Agents Phase 4
40 BB 1101 Phase 4
41 Oxazolidinones Phase 4
42 Anti-Infective Agents Phase 4
43 Neuroprotective Agents Phase 4
44 Anti-Obesity Agents Phase 4
45 Protective Agents Phase 4
46
Serotonin Investigational, Nutraceutical Phase 4,Phase 3 50-67-9 5202
47
Sodium oxybate Approved Phase 3 502-85-2 5360545
48
Verapamil Approved Phase 2, Phase 3 52-53-9 2520
49
Capsaicin Approved Phase 3 404-86-4 1548943
50 Cortivazol Investigational Phase 2, Phase 3 1110-40-3

Interventional clinical trials:

(show top 50) (show all 80)
# Name Status NCT ID Phase Drugs
1 Sumatriptan 4 mg Statdose in the Acute Treatment of Cluster Headache Unknown status NCT00399243 Phase 4 Sumatriptan 4mg Statdose injection
2 GON-block in Chronic Migraine: a Randomized, Double- Blind, Placebo-controlled Study Unknown status NCT02686983 Phase 4 Betamethasone and local anesthetic
3 Rizatriptan in Acute Treatment of Migraine in Patients With Unilateral Trigeminal-autonomic Symptoms. Completed NCT00753311 Phase 4 rizatriptan or placebo
4 A Comparison of Dexamethasone and Triamcinolone for Ultrasound-guided Occipital C2 Nerve Blocks Recruiting NCT02655523 Phase 4 Triamcinolone;Dexamethasone;Normal Saline;Bupivacaine
5 Efficacy and Safety of Zolmitriptan by Sublingual Administration Not yet recruiting NCT03377257 Phase 4 zolmitriptan by sublingual administration;zolmitriptan by oral
6 A Double-Blind, Placebo-Controlled Study Examining the Use of Topiramate in the Treatment of Cluster Headache Terminated NCT00203190 Phase 4 Topiramate
7 Sodium Oxybate in Patients With Episodic and Chronic Cluster Headache Unknown status NCT02637648 Phase 3 Sodium Oxybate;Placebo
8 Anodal Transcranial Direct Stimulation (tDCS) for the Treatment of Chronic Cluster Headache Completed NCT02462395 Phase 2, Phase 3
9 Cluster Headache Cortivazol Injection (CHCI) Completed NCT00804895 Phase 2, Phase 3 ALTIM, cortivazol injections;PROAMP, subcutaneous serum physiological saline;Verapamil
10 Intranasal Civamide for Episodic Cluster Headache Completed NCT00069082 Phase 3 Civamide (Zucapsaicin);Sodium Chloride
11 A Phase III Study of Civamide Nasal Solution (Zucapsaicin) for the Treatment of Episodic Cluster Headache Completed NCT00033839 Phase 3 Civamide (Zucapsaicin)
12 Study Of Sumatriptan Succinate Injection Kit In Patients With Migraine or Cluster Headache In Japan Completed NCT00356603 Phase 3 Sumatriptan Succinate
13 A Study Comparing the Efficacy and Safety of TEV-48125 (Fremanezumab) for the Prevention of Chronic Cluster Headache (CCH) Recruiting NCT02964338 Phase 3 Fremanezumab- A;Fremanezumab- B;Placebo
14 A Study to Evaluate the Efficacy and Safety of TEV-48125 (Fremanezumab) for the Prevention of Episodic Cluster Headache (ECH) Recruiting NCT02945046 Phase 3 Fremanezumab - A;Fremanezumab - B;Placebo
15 A Study of LY2951742 in Participants With Episodic Cluster Headache Active, not recruiting NCT02397473 Phase 3 LY2951742;Placebo
16 A Study of LY2951742 in Participants With Chronic Cluster Headache Active, not recruiting NCT02438826 Phase 3 LY2951742;Placebo
17 Occipital Nerve Stimulation in Medically Intractable Chronic Cluster Headache Active, not recruiting NCT01151631 Phase 3
18 A Study of LY2951742 (Galcanezumab) in Participants With Cluster Headache Enrolling by invitation NCT02797951 Phase 3 Galcanezumab
19 A Study to Explore the Long-Term Safety of TEV-48125 (Fremanezumab) for the Prevention of Cluster Headache Enrolling by invitation NCT03107052 Phase 3 Fremanezumab
20 Civamide Nasal Solution for Cluster Headache Not yet recruiting NCT01341548 Phase 3 Civamide nasal solution 0.01%
21 Randomized Evaluation of Octreotide Versus Compazine for Emergency Department Treatment of Migraine Headache Unknown status NCT00274170 Phase 1, Phase 2 Octreotide
22 Botox Injection in Treatment of Cluster Headache Completed NCT02019017 Phase 1, Phase 2 Botulinum Toxin Type A 25 IU;Botulinum Toxin Type A 50 IU
23 Prevention and Acute Treatment of Chronic Cluster Headache Compared to Standard of Care Completed NCT01701245 Phase 2
24 Prophylactic Treatment of Episodic Cluster Headache Completed NCT00184587 Phase 2 candesartan cilexetil;placebo
25 Occipital Nerve Stimulation to Treat Chronic Headaches Completed NCT00205894 Phase 1, Phase 2
26 Safety and Efficacy Study of SOM230 s.c. in Cluster Headache Recruiting NCT02619617 Phase 2 SOM230;Placebo
27 Botulinum Toxin Type A Block of the Otic Ganglion in Chronic Cluster Headache: Safety Issues Recruiting NCT03066635 Phase 1, Phase 2 Botulinum Toxin Type A 25 IU;Botulinum Toxin Type A 12.5 IU
28 Psilocybin-facilitated Treatment for Cocaine Use Recruiting NCT02037126 Phase 2 Psilocybin;Diphenhydramine
29 Pilot Study Evaluating the Use of Nasal Carbon Dioxide for the Treatment of Cluster Headache Terminated NCT02381795 Phase 2 Nasal Carbon Dioxide
30 R-Verapamil for the Prophylaxis of Episodic Cluster Headache Terminated NCT02209155 Phase 2 R-verapamil 75 mg tablet;Placebo
31 A Pilot Study of Demand Valve Oxygen Inhalation Therapy for Cluster Headache Unknown status NCT01298921 Phase 1 Oxygen;Oxygen
32 Psilocybin for the Treatment of Cluster Headache Recruiting NCT02981173 Phase 1 0.143 mg/kg Psilocybin;0.0143 mg/kg Psilocybin;Placebo
33 Pain Biomarker Study Active, not recruiting NCT03511846 Phase 1 Oral capsaicin;Topical capsaicin;Intranasal capsaicin;Low Flow Oxygen;High Flow Oxygen
34 Cluster Headache, Addictions and Vascular Function Unknown status NCT02640105
35 Cerebral Metabolism in Patients With Refractory Chronic Cluster Headache Treated by Occipital Nerve Stimulation Unknown status NCT02081482 Not Applicable
36 Physiotherapy Program for Cluster Headache Unknown status NCT02460003 Not Applicable
37 Baclofen in the Treatment of Muscle Cramps in Patients With Cirrhosis Unknown status NCT02221570 Not Applicable Baclofen
38 French Database of Occipital Nerves Stimulation in the Treatment of Refractory Chronic Headache Disorders Unknown status NCT01842763
39 Analysis of the Prevalence and Characteristics of Concomitant Sleep and Headache Disorders, and the Efficacy of CPAP Treatment for Headache Among Those Patients Diagnosed With Obstructive Sleep Apnea Unknown status NCT00520156
40 Inflammatory Markers Identification in Migraine Patients Unknown status NCT01618201
41 Identification of Inflammatory Markers in Migraine Patients Unknown status NCT00969995
42 Sleep in Cluster Headache: Sleep Parameters in- and Outside a Cluster Bout Completed NCT03439722
43 Circadian Rhythm and Attack-timing in Episodic Cluster Headache Patients in- and Outside of Bout: an Actigraphic Study Completed NCT02853487
44 Sleep, Circadian Rhythms and Cluster Headache Completed NCT01447641
45 Intranasal Cooling for Cluster Headache and Migraine Completed NCT01898455 Not Applicable
46 Non-invasive Neurostimulation of the Vagus Nerve for the Treatment of Cluster Headache Completed NCT01792817 Not Applicable
47 Cluster Headache and SPINK-1 Gene Completed NCT02585739 Not Applicable
48 Sphenopalatine Ganglion Stimulation for the Acute Treatment of Cluster Headache Completed NCT01255813 Not Applicable
49 Evaluation of Efficacity and Safety of Deep Brain Stimulation (DBS) in Chronic and Treatment-Resistant Cluster Headache(CH) Completed NCT00662935 Not Applicable
50 A Research Study to Examine Cutaneous Allodynia and Cluster Headache Completed NCT00329836

Search NIH Clinical Center for Cluster Headache

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Cluster Headache

Anatomical Context for Cluster Headache

MalaCards organs/tissues related to Cluster Headache:

41
Eye, Brain, Hypothalamus, Testes, Endothelial, Bone, Spinal Cord

Publications for Cluster Headache

Articles related to Cluster Headache:

(show top 50) (show all 720)
# Title Authors Year
1
High dosage of methylprednisolone in cluster headache. ( 29904864 )
2018
2
If you want to understand what it really means to live with cluster headache, imagine... fostering empathy through European patients' own stories of their experiences. ( 29633698 )
2018
3
Sphenopalatine ganglion stimulation for cluster headache, results from a large, open-label European registry. ( 29349561 )
2018
4
Cluster Headache Is in Part a Disorder of the Circadian System. ( 29800013 )
2018
5
Genetic association of HCRTR2, ADH4 and CLOCK genes with cluster headache: a Chinese population-based case-control study. ( 29318394 )
2018
6
Defective functional connectivity between posterior hypothalamus and regions of the diencephalic-mesencephalic junction in chronic cluster headache. ( 29517304 )
2018
7
Treatment of Cluster Headache. ( 29720813 )
2018
8
Cluster Headache Clinical Phenotypes: Tobacco Nonexposed (Never Smoker and No Parental Secondary Smoke Exposure as a Child) versus Tobacco-Exposed: Results from the United States Cluster Headache Survey. ( 29536529 )
2018
9
Managing cluster headache with sphenopalatine ganglion stimulation: a review. ( 29497328 )
2018
10
Chronorisk in cluster headache: A tool for individualised therapy? ( 29635936 )
2018
11
Population-Based Analysis of Cluster Headache-Associated Genetic Polymorphisms. ( 29959630 )
2018
12
Diagnosis, pathophysiology, and management of cluster headache. ( 29174963 )
2018
13
Aura in Cluster Headache: A Cross-Sectional Study. ( 29933513 )
2018
14
Changes in medication cost observed in chronic cluster headache patients treated with sphenopalatine ganglion (SPG) stimulation: Analysis based on 1-year data from the Pathway R-1 Registry. ( 29921140 )
2018
15
Trigeminal Nerve Sheath Tumor Presenting as a Cluster Headache. ( 29782034 )
2018
16
Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache. ( 29850313 )
2018
17
Cluster headache. ( 29493575 )
2018
18
Noninvasive neuromodulation in migraine and cluster headache. ( 29601305 )
2018
19
Greater Occipital Nerve Injection versus Oral Steroids for Short Term Prophylaxis of Cluster Headache: A Retrospective Comparative Study. ( 29782047 )
2018
20
Cluster Headache: Epidemiology, Pathophysiology, Clinical Features, and Diagnosis. ( 29720812 )
2018
21
OnabotulinumtoxinA in the treatment of refractory chronic cluster headache. ( 29915913 )
2018
22
Cluster headache: new targets and options for treatment. ( 29623198 )
2018
23
Societal burden of cluster headache in the United States: a descriptive economic analysis. ( 29125368 )
2018
24
Systematic review of the safety and effectiveness of peripheral neurostimulation of the sphenopalatine ganglion for the treatment of refractory chronic cluster headache. ( 29338934 )
2018
25
Cluster headache is associated with unhealthy lifestyle and lifestyle-related comorbid diseases: Results from the Danish Cluster Headache Survey. ( 29933701 )
2018
26
STN DBS for Advanced Parkinson Disease Simultaneously Alleviates Cluster Headache. ( 29422851 )
2017
27
Clinical Characteristics and Treatment Patterns Among Patients Diagnosed With Cluster Headache in U.S. Healthcare Claims Data. ( 28581025 )
2017
28
Personality disorders in cluster headache: a study using the Millon Clinical Multiaxial Inventory-III. ( 28527059 )
2017
29
Pre-attack signs and symptoms in cluster headache: Characteristics and time profile. ( 28816505 )
2017
30
Calcitonin Gene-Related Peptide-Targeted Therapies for Migraine and Cluster Headache: A Review. ( 28644160 )
2017
31
Sphenopalatine ganglion stimulation induces changes in cardiac autonomic regulation in cluster headache. ( 29105279 )
2017
32
Economics of Inhaled Oxygen Use as an Acute Therapy for Cluster Headache in the United States of America. ( 28842974 )
2017
33
Cost-effectiveness of gammaCore (non-invasive vagus nerve stimulation) for acute treatment of episodic cluster headache. ( 29144720 )
2017
34
Cranial parasympathetic activation induces autonomic symptoms but no cluster headache attacks. ( 29082824 )
2017
35
CGRP, a target for preventive therapy in migraine and cluster headache: Systematic review of clinical data. ( 29110503 )
2017
36
Pathogenesis of chronic cluster headache and bouts: role of tryptamine, arginine metabolism and I+1-agonists. ( 28527056 )
2017
37
Naratriptan in the Prophylactic Treatment of Cluster Headache. ( 28883254 )
2017
38
Peripheral provocation of cranial autonomic symptoms is not sufficient to trigger cluster headache attacks. ( 29082823 )
2017
39
Clomiphene treatment may be effective in refractory episodic and chronic cluster headache. ( 28977141 )
2017
40
Oxygen for Cluster Headache. ( 28967120 )
2017
41
Childhood-Onset Cluster Headache: Observations From a Personal Case-Series and Review of the Literature. ( 29226466 )
2017
42
Non-invasive vagus nerve stimulation for the acute treatment of episodic and chronic cluster headache: A randomized, double-blind, sham-controlled ACT2 study. ( 29231763 )
2017
43
Cluster headache - clinical pattern and a new severity scale in a Swedish cohort. ( 28906127 )
2017
44
The pathophysiology of episodic cluster headache: Insights from recent neuroimaging research. ( 28677993 )
2017
45
Ketamine Infusion Combined With Magnesium as a Therapy for Intractable Chronic Cluster Headache: Report of Two Cases. ( 28670718 )
2017
46
Improved surgical procedure using intraoperative navigation for the implantation of the SPG microstimulator in patients with chronic cluster headache. ( 28083804 )
2017
47
Cluster headache and middle meningeal artery dural arteriovenous fistulas: A case report. ( 29199428 )
2017
48
Carotid dissection presenting as a prolonged cluster-like headache in a patient with episodic cluster headache. ( 28765481 )
2017
49
The comorbidity burden of patients with cluster headache: a population-based study. ( 28741257 )
2017
50
Naratriptan May Become an Alternative Prophylactic Option for Patients with Cluster Headache. ( 28883259 )
2017

Variations for Cluster Headache

Expression for Cluster Headache

Search GEO for disease gene expression data for Cluster Headache.

Pathways for Cluster Headache

Pathways related to Cluster Headache according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.62 CACNA1A CALCA NOS1
2 11.46 CALCA HCRT NOS1 VIP
3 10.93 CACNA1A NOS1

GO Terms for Cluster Headache

Biological processes related to Cluster Headache according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor signaling pathway GO:0007186 9.85 CALCA HCRT HCRTR2 VIP
2 regulation of signaling receptor activity GO:0010469 9.73 CALCA HCRT VIP
3 chemical synaptic transmission GO:0007268 9.63 CACNA1A HCRT HCRTR2
4 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.54 CALCA VIP
5 regulation of insulin secretion GO:0050796 9.52 CACNA1A CLOCK
6 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 9.51 HCRT HCRTR2
7 positive regulation of cytosolic calcium ion concentration GO:0007204 9.5 CACNA1A CALCA HCRT
8 response to heat GO:0009408 9.49 CALCA NOS1
9 regulation of cytosolic calcium ion concentration GO:0051480 9.48 CALCA HCRTR2
10 negative regulation of blood pressure GO:0045776 9.43 CALCA NOS1
11 vasodilation GO:0042311 9.4 CALCA NOS1
12 response to pain GO:0048265 9.37 CACNA1A CALCA
13 neuropeptide signaling pathway GO:0007218 9.33 CALCA HCRT HCRTR2
14 negative regulation of potassium ion transport GO:0043267 9.26 HCRT NOS1
15 negative regulation of calcium ion transport into cytosol GO:0010523 8.96 CALCA NOS1
16 feeding behavior GO:0007631 8.8 CALCA HCRT HCRTR2

Molecular functions related to Cluster Headache according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 8.62 HCRT VIP

Sources for Cluster Headache

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
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49 NCI
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51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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