MCID: CTR186
MIFTS: 28

Co-Trimoxazole Allergy

Categories: Immune diseases

Aliases & Classifications for Co-Trimoxazole Allergy

MalaCards integrated aliases for Co-Trimoxazole Allergy:

Name: Co-Trimoxazole Allergy 12 15
Trimethoprim/sulfamethoxazole Allergy 12
Cotrimoxazol Allergy 12
Bactrim Allergy 12
Tmp/smx Allergy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0040070
SNOMED-CT 67 294594004
UMLS 71 C0571504

Summaries for Co-Trimoxazole Allergy

Disease Ontology : 12 A drug allergy that has allergic trigger co-trimoxazole.

MalaCards based summary : Co-Trimoxazole Allergy, also known as trimethoprim/sulfamethoxazole allergy, is related to cephalosporin allergy and pseudomembranous conjunctivitis. An important gene associated with Co-Trimoxazole Allergy is FRK (Fyn Related Src Family Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Related phenotypes are Decreased viability and Decreased viability

Related Diseases for Co-Trimoxazole Allergy

Graphical network of the top 20 diseases related to Co-Trimoxazole Allergy:



Diseases related to Co-Trimoxazole Allergy

Symptoms & Phenotypes for Co-Trimoxazole Allergy

GenomeRNAi Phenotypes related to Co-Trimoxazole Allergy according to GeneCards Suite gene sharing:

26 (show top 50) (show all 73)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 11.17 PIK3C2A SYK
2 Decreased viability GR00055-A-2 11.17 PIK3C2A SYK
3 Decreased viability GR00055-A-3 11.17 PIK3C2A LCK
4 Decreased viability GR00221-A-1 11.17 PIK3C2A LCK SYK HCK FYN KIT
5 Decreased viability GR00221-A-2 11.17 PIK3C2A LCK SYK YES1 FGR HCK
6 Decreased viability GR00221-A-3 11.17 LYN LCK SYK YES1
7 Decreased viability GR00221-A-4 11.17 PIK3C2A YES1 BLK FGR HCK
8 Decreased viability GR00240-S-1 11.17 PIK3C2A FYN
9 Decreased viability GR00249-S 11.17 PIK3C2A SYK
10 Decreased viability GR00301-A 11.17 LCK KIT
11 Decreased viability GR00342-S-1 11.17 PIK3C2A LCK
12 Decreased viability GR00342-S-2 11.17 PIK3C2A
13 Decreased viability GR00342-S-3 11.17 PIK3C2A LCK FGR
14 Decreased viability GR00386-A-1 11.17 LCK SYK
15 Decreased viability GR00402-S-2 11.17 SYK BLK
16 Decreased substrate adherent cell growth GR00193-A-1 10.57 BLK FRK HCK KIT
17 Decreased substrate adherent cell growth GR00193-A-2 10.57 KIT LCK YES1 FYN SYK
18 Decreased substrate adherent cell growth GR00193-A-3 10.57 LCK YES1
19 Decreased substrate adherent cell growth GR00193-A-4 10.57 BLK KIT LCK YES1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-106 10.51 LYN
21 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.51 LCK
22 Increased shRNA abundance (Z-score > 2) GR00366-A-139 10.51 YES1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-140 10.51 YES1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-145 10.51 YES1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-15 10.51 FRK
26 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.51 KIT
27 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.51 KIT
28 Increased shRNA abundance (Z-score > 2) GR00366-A-170 10.51 KIT
29 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.51 FRK
30 Increased shRNA abundance (Z-score > 2) GR00366-A-179 10.51 HCK
31 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.51 LCK
32 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.51 HCK
33 Increased shRNA abundance (Z-score > 2) GR00366-A-201 10.51 FRK
34 Increased shRNA abundance (Z-score > 2) GR00366-A-211 10.51 FRK
35 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.51 FYN
36 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.51 KIT
37 Increased shRNA abundance (Z-score > 2) GR00366-A-41 10.51 LYN
38 Increased shRNA abundance (Z-score > 2) GR00366-A-5 10.51 FRK
39 Increased shRNA abundance (Z-score > 2) GR00366-A-60 10.51 FYN HCK LYN YES1
40 Increased shRNA abundance (Z-score > 2) GR00366-A-61 10.51 KIT
41 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.51 LYN
42 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.51 FRK FYN HCK KIT LCK LYN
43 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.51 KIT
44 Increased shRNA abundance (Z-score > 2) GR00366-A-98 10.51 LCK
45 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.51 HCK KIT
46 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 10.39 HCK
47 Decreased shRNA abundance (Z-score < -2) GR00366-A-113 10.39 FYN
48 Decreased shRNA abundance (Z-score < -2) GR00366-A-114 10.39 YES1
49 Decreased shRNA abundance (Z-score < -2) GR00366-A-126 10.39 HCK
50 Decreased shRNA abundance (Z-score < -2) GR00366-A-130 10.39 HCK

MGI Mouse Phenotypes related to Co-Trimoxazole Allergy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.17 BLK CD69 ENPP3 FGR FYN HCK
2 immune system MP:0005387 10.13 BLK CD69 ENPP3 FGR FYN HCK
3 integument MP:0010771 9.76 FGR FYN HSPG2 KIT LYN PPL
4 renal/urinary system MP:0005367 9.56 FYN KIT LYN PIK3C2A PPL STAT6
5 respiratory system MP:0005388 9.28 ENPP3 HCK HSPG2 KIT LYN OGA

Drugs & Therapeutics for Co-Trimoxazole Allergy

Search Clinical Trials , NIH Clinical Center for Co-Trimoxazole Allergy

Genetic Tests for Co-Trimoxazole Allergy

Anatomical Context for Co-Trimoxazole Allergy

Publications for Co-Trimoxazole Allergy

Articles related to Co-Trimoxazole Allergy:

# Title Authors PMID Year
1
Probable loop diuretic-induced pancreatitis in a sulfonamide-allergic patient. 61
16352777 2006

Variations for Co-Trimoxazole Allergy

Expression for Co-Trimoxazole Allergy

Search GEO for disease gene expression data for Co-Trimoxazole Allergy.

Pathways for Co-Trimoxazole Allergy

Pathways related to Co-Trimoxazole Allergy according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14 YES1 SYK STAT6 PPL LYN LCK
2
Show member pathways
13.42 YES1 SYK PPL LYN LCK KIT
3
Show member pathways
13.34 YES1 SYK STAT6 LYN LCK KIT
4
Show member pathways
13.27 YES1 SYK LYN LCK FYN FGR
5
Show member pathways
13.18 SYK STAT6 PIK3C2A LYN LCK FYN
6
Show member pathways
13.03 SYK LYN LCK KIT HSPG2 FYN
7
Show member pathways
12.87 SYK STAT6 LYN LCK FYN
8
Show member pathways
12.83 YES1 LYN LCK FYN BLK
9
Show member pathways
12.78 SYK LYN KIT FYN
10
Show member pathways
12.72 SYK LYN LCK KIT FYN BLK
11 12.68 SYK STAT6 LYN LCK KIT HCK
12
Show member pathways
12.49 YES1 LYN LCK FYN
13
Show member pathways
12.47 SYK LCK GZMB FYN
14
Show member pathways
12.47 YES1 STAT6 LYN LCK FYN BLK
15
Show member pathways
12.4 SYK LYN LCK FYN BLK
16
Show member pathways
12.36 YES1 SYK LYN HCK FYN FGR
17
Show member pathways
12.35 SYK LYN HCK GZMB
18
Show member pathways
12.35 SYK PIK3C2A LCK FYN
19
Show member pathways
12.33 SYK LYN KIT HCK FYN ENPP3
20
Show member pathways
12.21 YES1 LYN LCK FYN
21
Show member pathways
12.19 YES1 LYN LCK FYN
22 12.19 YES1 SYK LYN LCK KIT HCK
23
Show member pathways
12.15 YES1 LYN LCK HCK FYN FGR
24
Show member pathways
12.13 SYK LYN LCK FYN
25
Show member pathways
12.07 SYK LYN LCK FYN
26 12.04 YES1 LYN LCK HCK FYN
27
Show member pathways
12 SYK LYN HCK
28 11.99 SYK LCK FYN
29 11.97 SYK LYN FYN
30
Show member pathways
11.95 SYK LYN FYN BLK
31
Show member pathways
11.93 STAT6 LCK GZMB
32 11.92 SYK LYN LCK FYN
33 11.92 YES1 LYN LCK HCK FYN FGR
34
Show member pathways
11.91 SYK LYN FYN
35 11.89 SYK LYN LCK
36 11.83 SYK LYN HCK
37
Show member pathways
11.8 LCK HCK FYN
38
Show member pathways
11.8 YES1 SYK LYN HCK FYN FGR
39 11.75 YES1 LYN LCK HCK FYN FGR
40 11.7 YES1 LYN LCK HCK FYN FGR
41 11.69 SYK LCK FYN
42 11.67 YES1 STAT6 LYN LCK HCK FYN
43 11.66 YES1 LYN LCK HCK FYN FGR
44 11.56 YES1 LYN LCK HCK FYN FGR
45 11.3 YES1 LYN LCK HCK FYN FGR
46 11.22 YES1 LYN LCK HCK FYN FGR
47 11.21 YES1 SYK LYN HCK FYN
48 11.21 YES1 SYK LYN LCK HCK FYN
49 11.14 YES1 LYN LCK KIT FYN
50 11.13 YES1 LYN LCK HCK FYN FGR

GO Terms for Co-Trimoxazole Allergy

Cellular components related to Co-Trimoxazole Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.28 YES1 SYK PPL PIK3C2A OGA LYN
2 cytoplasm GO:0005737 10.21 YES1 SYK STAT6 PPL PIK3C2A OGA
3 plasma membrane GO:0005886 10 YES1 SYK PPL PIK3C2A LYN LCK
4 extracellular exosome GO:0070062 9.97 YES1 PPL PIK3C2A LYN LCK HSPG2
5 cytosol GO:0005829 9.8 YES1 SYK STAT6 PPL PIK3C2A OGA
6 membrane raft GO:0045121 9.73 STAT6 LYN LCK FYN
7 actin filament GO:0005884 9.63 YES1 HCK FYN
8 mast cell granule GO:0042629 9.48 LYN KIT
9 extrinsic component of cytoplasmic side of plasma membrane GO:0031234 9.28 YES1 SYK LYN LCK HCK FYN
10 postsynaptic specialization, intracellular component GO:0099091 9.26 YES1 LYN

Biological processes related to Co-Trimoxazole Allergy according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 10.16 YES1 SYK LYN LCK HSPG2 HCK
2 innate immune response GO:0045087 10.09 YES1 SYK LYN LCK HCK FYN
3 viral process GO:0016032 10.07 SYK OGA LYN LCK HCK FYN
4 protein phosphorylation GO:0006468 10.07 YES1 SYK LYN LCK KIT HCK
5 phosphorylation GO:0016310 10.06 YES1 SYK PIK3C2A LYN LCK KIT
6 intracellular signal transduction GO:0035556 10.04 SYK LYN KIT FYN BLK
7 cytokine-mediated signaling pathway GO:0019221 9.97 STAT6 KIT HCK FYN
8 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 9.95 YES1 SYK LYN HCK FYN FGR
9 protein autophosphorylation GO:0046777 9.95 YES1 SYK LYN KIT HCK FYN
10 leukocyte migration GO:0050900 9.93 YES1 LYN LCK FYN
11 regulation of cell shape GO:0008360 9.92 KIT HCK FYN FGR
12 peptidyl-tyrosine phosphorylation GO:0018108 9.91 YES1 SYK LYN LCK KIT HCK
13 B cell receptor signaling pathway GO:0050853 9.88 SYK LYN LCK BLK
14 platelet activation GO:0030168 9.86 SYK LYN LCK FYN
15 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.85 SYK LYN FYN
16 integrin-mediated signaling pathway GO:0007229 9.85 SYK HCK FGR
17 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.85 LYN KIT FYN FGR
18 ephrin receptor signaling pathway GO:0048013 9.84 YES1 LYN FYN
19 T cell costimulation GO:0031295 9.84 YES1 LYN LCK FYN
20 hemopoiesis GO:0030097 9.82 LYN LCK KIT
21 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.82 LYN KIT FYN
22 peptidyl-tyrosine autophosphorylation GO:0038083 9.81 YES1 SYK LYN LCK HCK FYN
23 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.75 LYN KIT FGR
24 regulation of defense response to virus by virus GO:0050690 9.74 LCK HCK FYN
25 regulation of phagocytosis GO:0050764 9.7 SYK HCK FGR
26 regulation of platelet aggregation GO:0090330 9.69 SYK LYN BLK
27 negative regulation of B cell proliferation GO:0030889 9.68 LYN BLK
28 dendritic cell differentiation GO:0097028 9.67 LYN BLK
29 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.67 STAT6 LYN
30 negative regulation of mast cell proliferation GO:0070667 9.67 LYN ENPP3 BLK
31 regulation of B cell receptor signaling pathway GO:0050855 9.66 LYN BLK
32 positive regulation of mast cell degranulation GO:0043306 9.65 SYK FGR
33 regulation of mast cell degranulation GO:0043304 9.65 LYN BLK
34 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.65 YES1 SYK LYN LCK KIT HCK
35 immune response-regulating cell surface receptor signaling pathway GO:0002768 9.63 LYN FGR
36 positive regulation of dendritic cell apoptotic process GO:2000670 9.62 LYN BLK
37 regulation of B cell apoptotic process GO:0002902 9.61 LYN BLK
38 tolerance induction to self antigen GO:0002513 9.61 LYN BLK
39 Fc receptor mediated stimulatory signaling pathway GO:0002431 9.6 LYN BLK
40 regulation of cell proliferation GO:0042127 9.36 YES1 SYK STAT6 LYN LCK KIT

Molecular functions related to Co-Trimoxazole Allergy according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 transferase activity GO:0016740 10.2 YES1 SYK PIK3C2A LYN LCK KIT
2 nucleotide binding GO:0000166 10.17 YES1 SYK PIK3C2A LYN LCK KIT
3 ATP binding GO:0005524 10.14 YES1 SYK PIK3C2A LYN LCK KIT
4 signaling receptor binding GO:0005102 9.97 YES1 SYK LYN LCK HCK FYN
5 protein kinase activity GO:0004672 9.96 YES1 SYK LYN LCK KIT HCK
6 kinase activity GO:0016301 9.9 YES1 SYK PIK3C2A LYN LCK KIT
7 phosphotyrosine residue binding GO:0001784 9.77 YES1 SYK LCK HCK FGR
8 ion channel binding GO:0044325 9.71 YES1 LYN FYN
9 SH2 domain binding GO:0042169 9.65 SYK LCK KIT
10 non-membrane spanning protein tyrosine kinase activity GO:0004715 9.61 YES1 SYK LYN LCK HCK FYN
11 phosphatidylinositol 3-kinase binding GO:0043548 9.55 LCK FYN
12 CD4 receptor binding GO:0042609 9.52 LCK FYN
13 T cell receptor binding GO:0042608 9.51 LCK FYN
14 CD8 receptor binding GO:0042610 9.49 LCK FYN
15 protein tyrosine kinase activity GO:0004713 9.32 YES1 SYK LYN LCK KIT HCK

Sources for Co-Trimoxazole Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....