MCID: CTR186
MIFTS: 30

Co-Trimoxazole Allergy

Categories: Immune diseases
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Aliases & Classifications for Co-Trimoxazole Allergy

MalaCards integrated aliases for Co-Trimoxazole Allergy:

Name: Co-Trimoxazole Allergy 11 14
Trimethoprim/sulfamethoxazole Allergy 11
Cotrimoxazol Allergy 11
Bactrim Allergy 11
Tmp/smx Allergy 11

Classifications:



External Ids:

Disease Ontology 11 DOID:0040070
SNOMED-CT 68 294594004
UMLS 71 C0571504

Summaries for Co-Trimoxazole Allergy

Disease Ontology: 11 A drug allergy that has allergic trigger co-trimoxazole.

MalaCards based summary: Co-Trimoxazole Allergy, also known as trimethoprim/sulfamethoxazole allergy, is related to cephalosporin allergy and beta-lactam allergy. An important gene associated with Co-Trimoxazole Allergy is ENPP3 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 3), and among its related pathways/superpathways are Innate Immune System and Disease. Related phenotypes are Decreased viability and Decreased viability

Related Diseases for Co-Trimoxazole Allergy

Diseases related to Co-Trimoxazole Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 cephalosporin allergy 10.3 HLA-B ENPP3
2 beta-lactam allergy 10.3 HLA-B ENPP3
3 solitary mastocytoma of the skin 10.2 KIT ENPP3
4 chlorhexidine allergy 10.2 SYK ENPP3
5 ceftazidime allergy 10.2 HLA-B ENPP3
6 abacavir allergy 10.2 HLA-B CYP2B6
7 intravascular fasciitis 10.1 KIT GCLC
8 aggressive systemic mastocytosis 10.1 LYN KIT ENPP3
9 acute basophilic leukemia 10.1 KIT ENPP3
10 benign fibrous mesothelioma 10.1 STAT6 KIT
11 vaginal endometrial stromal sarcoma 10.1 STAT6 KIT
12 penicillin allergy 10.1 HLA-B ENPP3
13 hantavirus pulmonary syndrome 10.1 SYK LYN
14 urticaria 10.0 SYK KIT ENPP3
15 exanthem 10.0 PIK3C2A KIT HLA-B
16 vagina sarcoma 10.0 STAT6 KIT
17 pneumocystosis 10.0
18 purpura 10.0
19 vasculitis 10.0
20 crohn's disease 10.0
21 hypersensitivity vasculitis 10.0
22 phenytoin allergy 10.0 SYK STAT6 HLA-B
23 autoimmune glomerulonephritis 9.9 SYK LYN
24 leukemia, acute lymphoblastic 9.8 SYK LYN KIT HLA-B HCK
25 common variable immunodeficiency 9.7 LCK HLA-B CD69 BLK
26 allergic asthma 9.7 SYK STAT6 CD69
27 carbapenem allergy 9.6 SYK STAT6 HLA-B ENPP3 CD69
28 cd45 deficiency 9.5 SYK LYN LCK HCK FYN FGR
29 dermatitis, atopic 9.5 SYK STAT6 CXCL9 CD69
30 immune deficiency disease 9.3 SYK STAT6 LCK HLA-B HCK CD69
31 skin disease 9.3 STAT6 KIT HLA-B CXCL9 CD69
32 systemic lupus erythematosus 9.0 SYK LYN LCK FYN CXCL9 CD69
33 asthma 8.8 SYK STAT6 LYN LCK HLA-B FYN
34 thrombocytopenia 8.8 YES1 SYK PIK3C2A LYN LCK KIT

Graphical network of the top 20 diseases related to Co-Trimoxazole Allergy:



Diseases related to Co-Trimoxazole Allergy

Symptoms & Phenotypes for Co-Trimoxazole Allergy

GenomeRNAi Phenotypes related to Co-Trimoxazole Allergy according to GeneCards Suite gene sharing:

25 (show top 50) (show all 57)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 11.27 SYK PIK3C2A
2 Decreased viability GR00055-A-2 11.27 SYK PIK3C2A
3 Decreased viability GR00055-A-3 11.27 LCK PIK3C2A
4 Decreased viability GR00221-A-1 11.27 LCK SYK HCK PIK3C2A FYN KIT
5 Decreased viability GR00221-A-2 11.27 LCK SYK YES1 FGR HCK PIK3C2A
6 Decreased viability GR00221-A-3 11.27 LCK LYN SYK YES1
7 Decreased viability GR00221-A-4 11.27 YES1 BLK FGR HCK PIK3C2A
8 Decreased viability GR00240-S-1 11.27 PIK3C2A FYN
9 Decreased viability GR00249-S 11.27 SYK PIK3C2A
10 Decreased viability GR00301-A 11.27 LCK KIT
11 Decreased viability GR00342-S-1 11.27 LCK PIK3C2A
12 Decreased viability GR00342-S-2 11.27 PIK3C2A
13 Decreased viability GR00342-S-3 11.27 LCK FGR PIK3C2A
14 Decreased viability GR00386-A-1 11.27 LCK SYK
15 Decreased viability GR00402-S-2 11.27 SYK BLK
16 Increased shRNA abundance (Z-score > 2) GR00366-A-106 10.59 LYN
17 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.59 LCK
18 Increased shRNA abundance (Z-score > 2) GR00366-A-139 10.59 YES1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-140 10.59 YES1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-145 10.59 YES1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-15 10.59 FRK
22 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.59 KIT
23 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.59 KIT
24 Increased shRNA abundance (Z-score > 2) GR00366-A-170 10.59 KIT
25 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.59 FRK
26 Increased shRNA abundance (Z-score > 2) GR00366-A-179 10.59 HCK
27 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.59 LCK
28 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.59 HCK
29 Increased shRNA abundance (Z-score > 2) GR00366-A-201 10.59 FRK
30 Increased shRNA abundance (Z-score > 2) GR00366-A-211 10.59 FRK
31 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.59 FYN
32 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.59 KIT
33 Increased shRNA abundance (Z-score > 2) GR00366-A-41 10.59 LYN
34 Increased shRNA abundance (Z-score > 2) GR00366-A-5 10.59 FRK
35 Increased shRNA abundance (Z-score > 2) GR00366-A-60 10.59 FYN HCK LYN YES1
36 Increased shRNA abundance (Z-score > 2) GR00366-A-61 10.59 KIT
37 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.59 LYN
38 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.59 FYN HCK LYN YES1 FRK KIT
39 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.59 KIT
40 Increased shRNA abundance (Z-score > 2) GR00366-A-98 10.59 LCK
41 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.59 HCK KIT
42 Decreased substrate adherent cell growth GR00193-A-1 10.57 BLK FRK HCK KIT
43 Decreased substrate adherent cell growth GR00193-A-2 10.57 KIT LCK YES1 FYN SYK
44 Decreased substrate adherent cell growth GR00193-A-3 10.57 LCK YES1
45 Decreased substrate adherent cell growth GR00193-A-4 10.57 BLK KIT LCK YES1
46 no effect GR00402-S-1 10.18 BLK CD276 CD69 CXCL9 CYP2B6 ENPP3
47 no effect GR00402-S-2 10.18 CD276 CD69 ENPP3 FGR FRK FYN
48 Increased viability GR00342-S-1 9.8 LYN
49 Increased viability GR00342-S-2 9.8 FRK LYN
50 Increased viability GR00342-S-3 9.8 LYN

MGI Mouse Phenotypes related to Co-Trimoxazole Allergy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.22 CYP2B6 ENPP3 FYN GCLC HCK HLA-B
2 immune system MP:0005387 10.22 BLK CD276 CD69 CXCL9 ENPP3 FGR
3 endocrine/exocrine gland MP:0005379 10.07 BLK CYP2B6 FYN HCK HLA-B KIT
4 hematopoietic system MP:0005397 9.89 BLK CD276 CD69 CXCL9 CYP2B6 ENPP3
5 respiratory system MP:0005388 9.86 ENPP3 HCK KIT LYN OGA STAT6
6 skeleton MP:0005390 9.81 CD276 CD69 CYP2B6 FGR HCK KIT
7 mortality/aging MP:0010768 9.44 CXCL9 ENPP3 FYN GCLC HCK HLA-B

Drugs & Therapeutics for Co-Trimoxazole Allergy

Search Clinical Trials, NIH Clinical Center for Co-Trimoxazole Allergy

Genetic Tests for Co-Trimoxazole Allergy

Anatomical Context for Co-Trimoxazole Allergy

Publications for Co-Trimoxazole Allergy

Articles related to Co-Trimoxazole Allergy:

# Title Authors PMID Year
1
Nocardiosis in Immunocompromised Patients on Alternative Pneumocystis Prophylaxis. 62
34545802 2021
2
Cross-reactivity between darunavir and trimethoprim-sulfamethoxazole in HIV-infected patients. 62
25985401 2015
3
Treatment of brucellosis in a young child with trimethoprim/sulfamethoxazole anaphylaxis. 62
25182510 2014
4
Sulfonamide allergies and outcomes related to use of potentially cross-reactive drugs in hospitalized patients. 62
16553515 2006
5
Probable loop diuretic-induced pancreatitis in a sulfonamide-allergic patient. 62
16352777 2006
6
Toxicity and efficacy of daily dapsone as Pneumocystis jiroveci prophylaxis after hematopoietic stem cell transplantation: a case-control study. 62
15983552 2005
7
Randomized controlled trial of 3 vs 10 days of trimethoprim/sulfamethoxazole for acute maxillary sinusitis. 62
7897784 1995
8
[A case from practice (173). AIDS IV C-1 with Isospora belli enteritis. Status following Pneumocystis carinii pneumonia. Bactrim allergy]. 62
2349414 1990
9
[Allergic vasculitis with arthritis due to bactrim allergy (author's transl)]. 62
408630 1977

Variations for Co-Trimoxazole Allergy

Expression for Co-Trimoxazole Allergy

Search GEO for disease gene expression data for Co-Trimoxazole Allergy.

Pathways for Co-Trimoxazole Allergy

Pathways related to Co-Trimoxazole Allergy according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 YES1 SYK STAT6 LYN LCK HLA-B
2
Show member pathways
13.72 FGR FYN GCLC HCK HLA-B KIT
3 13.71 YES1 SYK STAT6 LYN LCK KIT
4
Show member pathways
13.46 YES1 SYK LYN LCK HLA-B FYN
5
Show member pathways
13.41 SYK STAT6 PIK3C2A LYN LCK FYN
6
Show member pathways
13.23 YES1 SYK STAT6 LYN LCK HLA-B
7
Show member pathways
13.22 YES1 SYK LYN LCK FYN FGR
8
Show member pathways
13.19 FGR FYN HCK LYN SYK YES1
9
Show member pathways
12.84 SYK STAT6 LYN LCK FYN
10 12.75 YES1 STAT6 LYN LCK KIT FYN
11
Show member pathways
12.67 YES1 LYN LCK FYN BLK
12
Show member pathways
12.54 YES1 SYK LYN HCK FYN FGR
13
Show member pathways
12.52 YES1 SYK LYN HCK FYN FGR
14
Show member pathways
12.51 SYK LYN LCK FYN
15
Show member pathways
12.48 YES1 STAT6 LYN LCK KIT HLA-B
16
Show member pathways
12.4 YES1 LYN LCK FYN
17 12.32 SYK STAT6 LYN LCK KIT HCK
18
Show member pathways
12.31 FYN LCK LYN SYK YES1
19 12.22 HCK FYN FGR BLK
20
Show member pathways
12.19 FYN LCK PIK3C2A SYK
21
Show member pathways
12.14 YES1 LYN LCK FYN
22
Show member pathways
12.12 SYK LCK HLA-B FYN
23
Show member pathways
12.03 SYK LCK HCK FYN
24
Show member pathways
12.02 YES1 SYK LYN LCK HCK FYN
25 11.99 YES1 LYN FYN
26
Show member pathways
11.98 SYK LYN HCK
27
Show member pathways
11.94 SYK LCK FYN
28 11.89 YES1 KIT FYN
29 11.88 FYN HCK LCK LYN YES1
30
Show member pathways
11.8 YES1 LYN LCK KIT FYN
31 11.78 YES1 SYK LYN LCK KIT HCK
32
Show member pathways
11.76 FYN HCK LCK
33
Show member pathways
11.7 SYK LCK HLA-B FYN
34
Show member pathways
11.69 YES1 LYN FYN
35
Show member pathways
11.65 SYK LYN FYN
36
Show member pathways
11.61 FYN HCK LCK LYN PIK3C2A SYK
37
Show member pathways
11.53 SYK LYN HCK
38 11.52 SYK LYN LCK FYN
39
Show member pathways
11.35 YES1 GCLC FYN
40
Show member pathways
11.35 SYK LYN FYN BLK
41 11.01 LYN FYN
42 10.81 SYK LCK
43 10.79 YES1 LYN LCK HCK FYN FRK
44 10.65 LCK FYN

GO Terms for Co-Trimoxazole Allergy

Cellular components related to Co-Trimoxazole Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extrinsic component of cytoplasmic side of plasma membrane GO:0031234 9.58 YES1 SYK LYN LCK HCK FYN

Biological processes related to Co-Trimoxazole Allergy according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 10.49 YES1 SYK LYN LCK HCK FYN
2 innate immune response GO:0045087 10.4 BLK FGR FRK FYN HCK HLA-B
3 intracellular signal transduction GO:0035556 10.35 SYK LYN LCK KIT FYN BLK
4 protein phosphorylation GO:0006468 10.27 YES1 SYK LYN LCK KIT HCK
5 protein autophosphorylation GO:0046777 10.26 SYK LYN KIT HCK FYN FGR
6 regulation of cell shape GO:0008360 10.25 KIT HCK FYN FGR
7 B cell receptor signaling pathway GO:0050853 10.21 SYK LYN LCK BLK
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10.14 LYN KIT FYN
9 ephrin receptor signaling pathway GO:0048013 10.12 YES1 LYN FYN
10 T cell costimulation GO:0031295 10.11 YES1 LYN LCK FYN
11 immune system process GO:0002376 10.1 SYK LYN HLA-B HCK FYN FGR
12 phosphorylation GO:0016310 10.1 BLK FGR FRK FYN HCK KIT
13 leukocyte migration GO:0050900 10.06 YES1 LYN LCK FYN
14 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 10.04 LYN KIT FGR
15 negative regulation of inflammatory response to antigenic stimulus GO:0002862 10.03 YES1 SYK LYN HCK FYN FGR
16 stimulatory C-type lectin receptor signaling pathway GO:0002223 10.02 FYN LYN SYK
17 regulation of phagocytosis GO:0050764 10 SYK HCK FGR
18 regulation of platelet aggregation GO:0090330 9.97 BLK LYN SYK
19 positive regulation of mast cell degranulation GO:0043306 9.96 SYK FGR
20 growth hormone receptor signaling pathway via JAK-STAT GO:0060397 9.96 STAT6 LYN
21 peptidyl-tyrosine phosphorylation GO:0018108 9.96 BLK FGR FRK FYN HCK KIT
22 regulation of mast cell degranulation GO:0043304 9.95 LYN BLK
23 platelet degranulation GO:0002576 9.94 BLK LYN
24 immune response-regulating cell surface receptor signaling pathway GO:0002768 9.93 FGR LYN
25 regulation of B cell receptor signaling pathway GO:0050855 9.93 BLK LYN
26 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 9.93 YES1 SYK LYN HCK FYN FGR
27 tolerance induction to self antigen GO:0002513 9.92 LYN BLK
28 regulation of B cell apoptotic process GO:0002902 9.91 BLK LYN
29 negative regulation of mast cell proliferation GO:0070667 9.91 LYN ENPP3 BLK
30 positive regulation of mast cell cytokine production GO:0032765 9.9 KIT SYK
31 positive regulation of mast cell proliferation GO:0070668 9.89 KIT LYN
32 positive regulation of dendritic cell apoptotic process GO:2000670 9.88 BLK LYN
33 Fc receptor mediated stimulatory signaling pathway GO:0002431 9.86 LYN BLK
34 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.62 YES1 SYK LYN LCK KIT HCK

Molecular functions related to Co-Trimoxazole Allergy according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 10.54 BLK FGR FRK FYN GCLC HCK
2 signaling receptor binding GO:0005102 10.3 YES1 SYK LYN LCK HLA-B HCK
3 transferase activity GO:0016740 10.17 YES1 SYK PIK3C2A LYN LCK KIT
4 nucleotide binding GO:0000166 10.15 YES1 SYK PIK3C2A LYN LCK KIT
5 phosphotyrosine residue binding GO:0001784 10.1 FGR HCK LCK SYK YES1
6 protein kinase activity GO:0004672 10.06 BLK FGR FRK FYN HCK KIT
7 scaffold protein binding GO:0097110 10 SYK LYN FYN
8 SH2 domain binding GO:0042169 9.97 SYK LCK KIT
9 protein tyrosine kinase activity GO:0004713 9.96 BLK FGR FRK FYN HCK KIT
10 phospholipase binding GO:0043274 9.95 SYK LCK FYN
11 kinase activity GO:0016301 9.93 BLK FGR FRK FYN HCK KIT
12 phospholipase activator activity GO:0016004 9.81 LCK FYN
13 non-membrane spanning protein tyrosine kinase activity GO:0004715 9.58 YES1 SYK LYN LCK HCK FYN

Sources for Co-Trimoxazole Allergy

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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