Co-Trimoxazole Allergy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CTR186 MIFTS: 28	Co-Trimoxazole Allergy Categories: Immune diseases
Genes Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Co-Trimoxazole Allergy

MalaCards integrated aliases for Co-Trimoxazole Allergy:

Name: Co-Trimoxazole Allergy ¹² ¹⁵

Trimethoprim/sulfamethoxazole Allergy ¹²

Cotrimoxazol Allergy ¹²

Bactrim Allergy ¹²

Tmp/smx Allergy ¹²

Classifications:

MalaCards categories:
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0040070

SNOMED-CT ⁶⁷ 294594004

UMLS ⁷¹ C0571504

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Summaries for Co-Trimoxazole Allergy

Disease Ontology : ¹² A drug allergy that has allergic trigger co-trimoxazole.

MalaCards based summary : Co-Trimoxazole Allergy, also known as trimethoprim/sulfamethoxazole allergy, is related to cephalosporin allergy and pseudomembranous conjunctivitis. An important gene associated with Co-Trimoxazole Allergy is FRK (Fyn Related Src Family Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Co-Trimoxazole Allergy

Diseases related to Co-Trimoxazole Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)

#	Related Disease	Score	Top Affiliating Genes
1	cephalosporin allergy	10.3	PPL ENPP3
2	pseudomembranous conjunctivitis	10.2	PPL HSPG2
3	ceruminous adenocarcinoma	10.1	KIT HCK
4	purpura	10.1
5	vasculitis	10.1
6	nut allergy	10.0	STAT6 ENPP3
7	vaginal endometrial stromal sarcoma	10.0	STAT6 KIT
8	primary mediastinal b-cell lymphoma	9.9	SYK STAT6 LYN
9	hantavirus pulmonary syndrome	9.8	SYK LYN
10	vagina sarcoma	9.8	STAT6 KIT
11	autoimmune cardiomyopathy	9.6	LCK FYN
12	cd45 deficiency	9.6	LYN LCK FYN
13	benign fibrous mesothelioma	9.5	STAT6 LCK KIT
14	allergic hypersensitivity disease	9.4	SYK GZMB CD69
15	severe combined immunodeficiency	9.1	STAT6 LCK KIT FYN
16	common variable immunodeficiency	9.0	LCK GZMB CD69 BLK
17	human immunodeficiency virus type 1	8.9	LCK HCK FYN CD69
18	leukemia, chronic lymphocytic	8.9	SYK LYN LCK KIT CD69
19	carbapenem allergy	8.9	SYK STAT6 PPL GZMB ENPP3 CD69
20	leukemia, chronic myeloid	8.9	LYN LCK KIT HCK GZMB

Graphical network of the top 20 diseases related to Co-Trimoxazole Allergy:

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Symptoms & Phenotypes for Co-Trimoxazole Allergy

GenomeRNAi Phenotypes related to Co-Trimoxazole Allergy according to GeneCards Suite gene sharing:

²⁶ (show top 50) (show all 73)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-1	11.17	PIK3C2A SYK
2	Decreased viability	GR00055-A-2	11.17	PIK3C2A SYK
3	Decreased viability	GR00055-A-3	11.17	PIK3C2A LCK
4	Decreased viability	GR00221-A-1	11.17	PIK3C2A LCK SYK HCK FYN KIT
5	Decreased viability	GR00221-A-2	11.17	PIK3C2A LCK SYK YES1 FGR HCK
6	Decreased viability	GR00221-A-3	11.17	LYN LCK SYK YES1
7	Decreased viability	GR00221-A-4	11.17	PIK3C2A YES1 BLK FGR HCK
8	Decreased viability	GR00240-S-1	11.17	PIK3C2A FYN
9	Decreased viability	GR00249-S	11.17	PIK3C2A SYK
10	Decreased viability	GR00301-A	11.17	LCK KIT
11	Decreased viability	GR00342-S-1	11.17	PIK3C2A LCK
12	Decreased viability	GR00342-S-2	11.17	PIK3C2A
13	Decreased viability	GR00342-S-3	11.17	PIK3C2A LCK FGR
14	Decreased viability	GR00386-A-1	11.17	LCK SYK
15	Decreased viability	GR00402-S-2	11.17	SYK BLK
16	Decreased substrate adherent cell growth	GR00193-A-1	10.57	BLK FRK HCK KIT
17	Decreased substrate adherent cell growth	GR00193-A-2	10.57	KIT LCK YES1 FYN SYK
18	Decreased substrate adherent cell growth	GR00193-A-3	10.57	LCK YES1
19	Decreased substrate adherent cell growth	GR00193-A-4	10.57	BLK KIT LCK YES1
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-106	10.51	LYN
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-127	10.51	LCK
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-139	10.51	YES1
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-140	10.51	YES1
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-145	10.51	YES1
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-15	10.51	FRK
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-152	10.51	KIT
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-157	10.51	KIT
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-170	10.51	KIT
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-176	10.51	FRK
30	Increased shRNA abundance (Z-score > 2)	GR00366-A-179	10.51	HCK
31	Increased shRNA abundance (Z-score > 2)	GR00366-A-198	10.51	LCK
32	Increased shRNA abundance (Z-score > 2)	GR00366-A-2	10.51	HCK
33	Increased shRNA abundance (Z-score > 2)	GR00366-A-201	10.51	FRK
34	Increased shRNA abundance (Z-score > 2)	GR00366-A-211	10.51	FRK
35	Increased shRNA abundance (Z-score > 2)	GR00366-A-25	10.51	FYN
36	Increased shRNA abundance (Z-score > 2)	GR00366-A-30	10.51	KIT
37	Increased shRNA abundance (Z-score > 2)	GR00366-A-41	10.51	LYN
38	Increased shRNA abundance (Z-score > 2)	GR00366-A-5	10.51	FRK
39	Increased shRNA abundance (Z-score > 2)	GR00366-A-60	10.51	FYN HCK LYN YES1
40	Increased shRNA abundance (Z-score > 2)	GR00366-A-61	10.51	KIT
41	Increased shRNA abundance (Z-score > 2)	GR00366-A-83	10.51	LYN
42	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	10.51	FRK FYN HCK KIT LCK LYN
43	Increased shRNA abundance (Z-score > 2)	GR00366-A-9	10.51	KIT
44	Increased shRNA abundance (Z-score > 2)	GR00366-A-98	10.51	LCK
45	Increased shRNA abundance (Z-score > 2)	GR00366-A-99	10.51	HCK KIT
46	Decreased shRNA abundance (Z-score < -2)	GR00366-A-111	10.39	HCK
47	Decreased shRNA abundance (Z-score < -2)	GR00366-A-113	10.39	FYN
48	Decreased shRNA abundance (Z-score < -2)	GR00366-A-114	10.39	YES1
49	Decreased shRNA abundance (Z-score < -2)	GR00366-A-126	10.39	HCK
50	Decreased shRNA abundance (Z-score < -2)	GR00366-A-130	10.39	HCK

MGI Mouse Phenotypes related to Co-Trimoxazole Allergy:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.17	BLK CD69 ENPP3 FGR FYN HCK
2	immune system	MP:0005387	10.13	BLK CD69 ENPP3 FGR FYN HCK
3	integument	MP:0010771	9.76	FGR FYN HSPG2 KIT LYN PPL
4	renal/urinary system	MP:0005367	9.56	FYN KIT LYN PIK3C2A PPL STAT6
5	respiratory system	MP:0005388	9.28	ENPP3 HCK HSPG2 KIT LYN OGA

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Drugs & Therapeutics for Co-Trimoxazole Allergy

Search Clinical Trials , NIH Clinical Center for Co-Trimoxazole Allergy

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Genetic Tests for Co-Trimoxazole Allergy

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Anatomical Context for Co-Trimoxazole Allergy

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Publications for Co-Trimoxazole Allergy

Articles related to Co-Trimoxazole Allergy:

#	Title	Authors	PMID	Year
1	Probable loop diuretic-induced pancreatitis in a sulfonamide-allergic patient. ⁶¹	Juang P...Zolty R	16352777	2006

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Genes for Co-Trimoxazole Allergy

Genes related to Co-Trimoxazole Allergy (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	FRK	Fyn Related Src Family Tyrosine Kinase	Protein Coding	4.86	DISEASES inferred ¹⁵
2	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	4.69	DISEASES inferred ¹⁵
3	BLK	BLK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	4.59	DISEASES inferred ¹⁵
4	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	4.59	DISEASES inferred ¹⁵
5	FGR	FGR Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	4.54	DISEASES inferred ¹⁵
6	ENPP3	Ectonucleotide Pyrophosphatase/Phosphodiesterase 3	Protein Coding	4.53	DISEASES inferred ¹⁵
7	PPL	Periplakin	Protein Coding	4.41	DISEASES inferred ¹⁵
8	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	4.24	DISEASES inferred ¹⁵
9	OGA	O-GlcNAcase	Protein Coding	4.06	DISEASES inferred ¹⁵
10	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3.96	DISEASES inferred ¹⁵
11	HSPG2	Heparan Sulfate Proteoglycan 2	Protein Coding	3.95	DISEASES inferred ¹⁵
12	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3.88	DISEASES inferred ¹⁵
13	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	3.85	DISEASES inferred ¹⁵
14	HCK	HCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3.8	DISEASES inferred ¹⁵
15	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	3.75	DISEASES inferred ¹⁵
16	CD69	CD69 Molecule	Protein Coding	3.66	DISEASES inferred ¹⁵
17	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3.65	DISEASES inferred ¹⁵
18	GZMB	Granzyme B	Protein Coding	3.52	DISEASES inferred ¹⁵

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Variations for Co-Trimoxazole Allergy

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Expression for Co-Trimoxazole Allergy

Search GEO for disease gene expression data for Co-Trimoxazole Allergy.

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Pathways for Co-Trimoxazole Allergy

Pathways related to Co-Trimoxazole Allergy according to GeneCards Suite gene sharing:

(show top 50) (show all 54)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	14	YES1 SYK STAT6 PPL LYN LCK
2	Class I MHC mediated antigen processing and presentation ⁶⁵ Show member pathways Adaptive Immune System ⁶⁵ Antigen processing- Ubiquitination and Proteasome degradation ⁶⁵	13.42	YES1 SYK PPL LYN LCK KIT
3	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.34	YES1 SYK STAT6 LYN LCK KIT
4	Response to elevated platelet cytosolic Ca2+ ⁶⁵ Show member pathways Disinhibition of SNARE formation ⁶⁵ Hemostasis ⁶⁵ Platelet activation, signaling and aggregation ⁶⁵ Platelet degranulation ⁶⁵	13.27	YES1 SYK LYN LCK FYN FGR
5	IL-2 Pathway ⁶³ Show member pathways ErbB Family Pathway ⁶³ ErbB2-ErbB3 Heterodimers ⁶³ ErbB4 Pathway ⁶³ Growth Hormone Signaling ⁶³ HMGB1 Pathway ⁶³ IL-4 Pathway ⁶³ LPS Stimulated MAPK Signaling ⁶³ PACAP Signaling ⁶³ PI3K Signaling in B-Lymphocyte ⁶³ Prolactin Signaling ⁶³ Thrombopoietin Pathway ⁶³ TREM1 Pathway ⁶³ UVC-Induced MAPK Signaling ⁶³	13.18	SYK STAT6 PIK3C2A LYN LCK FYN
6	Phospholipase-C Pathway ⁶³ Show member pathways PTEN Pathway ⁶³	13.03	SYK LYN LCK KIT HSPG2 FYN
7	TCR Signaling (Qiagen) ⁶³ Show member pathways ITK and TCR Signaling ⁶³ PDGF Pathway ⁶³ PKC-Theta Pathway ⁶³ TCR Signaling ⁶³	12.87	SYK STAT6 LYN LCK FYN
8	MAPK Erk Pathway ⁶⁶ Show member pathways Actin Dynamics Signaling Pathway ⁶⁶ G Protein coupled Receptors Signaling ⁶⁶	12.83	YES1 LYN LCK FYN BLK
9	Development Angiotensin activation of ERK ²² Show member pathways Cell adhesion Integrin inside-out signaling ²² Development ACM2 and ACM4 activation of ERK ²² Development Angiotensin signaling via PYK2 ²² Development EDNRB signaling ²² Development EPO-induced MAPK pathway ²² Development G-Proteins mediated regulation MARK-ERK signaling ²² Signal transduction IP3 signaling ²²	12.78	SYK LYN KIT FYN
10	Downstream signaling events of B Cell Receptor (BCR) ⁶⁵ Show member pathways Activation of RAS in B cells ⁶⁵ Signaling by the B Cell Receptor (BCR) ⁶⁵	12.72	SYK LYN LCK KIT FYN BLK
11	NF-kappaB Signaling ⁴	12.68	SYK STAT6 LYN LCK KIT HCK
12	S45 mutants of beta-catenin arent phosphorylated ⁶⁵ Show member pathways AMER1 mutants destabilize the destruction complex ⁶⁵ APC truncation mutants are not K63 polyubiquitinated ⁶⁵ APC truncation mutants have impaired AXIN binding ⁶⁵ AXIN missense mutants destabilize the destruction complex ⁶⁵ AXIN mutants destabilize the destruction complex, activating WNT signaling ⁶⁵ Beta-catenin phosphorylation cascade ⁶⁵ Canonical Wnt signaling pathway ¹ CTLA4 inhibitory signaling ⁶⁵ Disassembly of the destruction complex and recruitment of AXIN to the membrane ⁶⁵ Misspliced GSK3beta mutants stabilize beta-catenin ⁶⁵ phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex ⁶⁵ S33 mutants of beta-catenin arent phosphorylated ⁶⁵ S37 mutants of beta-catenin arent phosphorylated ⁶⁵ Signaling by WNT in cancer ⁶⁵ T41 mutants of beta-catenin arent phosphorylated ⁶⁵ truncated APC mutants destabilize the destruction complex ⁶⁵ Truncations of AMER1 destabilize the destruction complex ⁶⁵	12.49	YES1 LYN LCK FYN
13	Immune response Role of DAP12 receptors in NK cells ²² Show member pathways Immune response CD16 signaling in NK cells ²² Natural killer cell mediated cytotoxicity ³⁶	12.47	SYK LCK GZMB FYN
14	JAK-STAT signaling pathway ³⁶ Show member pathways B-Cell Development ⁶³ IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴ Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴ Type III interferon signaling ¹	12.47	YES1 STAT6 LYN LCK FYN BLK
15	B cell receptor signaling pathway (KEGG) ³⁶ Show member pathways B Cell Receptor Signaling Pathway ¹ BCR signaling pathway ¹	12.4	SYK LYN LCK FYN BLK
16	Regulation of actin dynamics for phagocytic cup formation ⁶⁵ Show member pathways Fcgamma receptor (FCGR) dependent phagocytosis ⁶⁵ RHO GTPases Activate WASPs and WAVEs ⁶⁵	12.36	YES1 SYK LYN HCK FYN FGR
17	RhoGDI Pathway ⁶³ Show member pathways Fc-GammaR-Mediated Phagocytosis in Macrophages ⁶³	12.35	SYK LYN HCK GZMB
18	ICos-ICosL Pathway in T-Helper Cell ⁶³ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶³ CD28 Signaling in T-Helper Cell ⁶³	12.35	SYK PIK3C2A LCK FYN
19	Kit receptor signaling pathway ¹ Show member pathways IL-3 Signaling Pathway ¹ Signaling events mediated by Stem cell factor receptor (c-Kit) ¹	12.33	SYK LYN KIT HCK FYN ENPP3
20	Cell surface interactions at the vascular wall ⁶⁵ Show member pathways Fibronectin matrix formation ⁶⁵ PECAM1 interactions ⁶⁵ Tie2 Signaling ⁶⁵	12.21	YES1 LYN LCK FYN
21	CD28 co-stimulation ⁶⁵ Show member pathways Activation of AKT2 ⁶⁵ CD28 dependent PI3K/Akt signaling ⁶⁵ CD28 dependent Vav1 pathway ⁶⁵ Costimulation by the CD28 family ⁶⁵ VEGFR2 mediated vascular permeability ⁶⁵	12.19	YES1 LYN LCK FYN
22	Tyrosine Kinases / Adaptors ⁴	12.19	YES1 SYK LYN LCK KIT HCK
23	EPHA forward signaling ¹ Show member pathways EPHA-mediated growth cone collapse ⁶⁵ Ephrin A reverse signaling ¹ EphrinA-EPHA pathway ¹ EphrinA-EphR Signaling ⁶³	12.15	YES1 LYN LCK HCK FYN FGR
24	G beta-gamma signalling through PI3Kgamma ⁶⁵ Show member pathways G-protein beta-gamma signalling ⁶⁵ GPVI-mediated activation cascade ⁶⁵	12.13	SYK LYN LCK FYN
25	IL-2 Signaling Pathway ¹ Show member pathways IL2-mediated signaling events ¹ IL-5 Signaling Pathway ¹	12.07	SYK LYN LCK FYN
26	MAP Kinase Signaling ⁴	12.04	YES1 LYN LCK HCK FYN
27	Fc-GammaR Pathway ⁶³ Show member pathways Fc-Gamma-RIIB Signaling in B-Cells ⁶³	12	SYK LYN HCK
28	Osteoclast differentiation ³⁶	11.99	SYK LCK FYN
29	Platelet activation ³⁶	11.97	SYK LYN FYN
30	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers ⁶⁵ Show member pathways B-Cell Receptor Complex ⁶³ CD22 mediated BCR regulation ⁶⁵ CLEC7A (Dectin-1) induces NFAT activation ⁶⁵ FCERI mediated Ca+2 mobilization ⁶⁵	11.95	SYK LYN FYN BLK
31	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	11.93	STAT6 LCK GZMB
32	NF-kB(NFkB) Pathway ⁶⁶	11.92	SYK LYN LCK FYN
33	CXCR4-mediated signaling events ¹	11.92	YES1 LYN LCK HCK FYN FGR
34	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) ⁶⁵ Show member pathways Dectin-2 family ⁶⁵ Defective GALNT12 causes colorectal cancer 1 (CRCS1) ⁶⁵ Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) ⁶⁵ Termination of O-glycan biosynthesis ⁶⁵	11.91	SYK LYN FYN
35	NF-kappa B signaling pathway ³⁶	11.89	SYK LYN LCK
36	Fc gamma R-mediated phagocytosis ³⁶	11.83	SYK LYN HCK
37	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters ⁶⁵ Show member pathways Nef and signal transduction ⁶⁵ Nef Mediated CD4 Down-regulation ⁶⁵ Nef Mediated CD8 Down-regulation ⁶⁵ Nef mediated downregulation of CD28 cell surface expression ⁶⁵ Nef mediated downregulation of MHC class I complex cell surface expression ⁶⁵ The role of Nef in HIV-1 replication and disease pathogenesis ⁶⁵	11.8	LCK HCK FYN
38	Role of phospholipids in phagocytosis ⁶⁵ Show member pathways FCGR activation ⁶⁵	11.8	YES1 SYK LYN HCK FYN FGR
39	PDGFR-beta signaling pathway ¹	11.75	YES1 LYN LCK HCK FYN FGR
40	Signaling events mediated by PTP1B ¹	11.7	YES1 LYN LCK HCK FYN FGR
41	CTLA4 Signaling ⁶³	11.69	SYK LCK FYN
42	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway ¹	11.67	YES1 STAT6 LYN LCK HCK FYN
43	amb2 Integrin signaling ¹	11.66	YES1 LYN LCK HCK FYN FGR
44	Class I PI3K signaling events ¹	11.56	YES1 LYN LCK HCK FYN FGR
45	Regulation of p38-alpha and p38-beta ¹	11.3	YES1 LYN LCK HCK FYN FGR
46	Glypican 1 network ¹	11.22	YES1 LYN LCK HCK FYN FGR
47	Regulation of signaling by CBL ⁶⁵	11.21	YES1 SYK LYN HCK FYN
48	Thromboxane A2 receptor signaling ¹	11.21	YES1 SYK LYN LCK HCK FYN
49	Regulation of KIT signaling ⁶⁵	11.14	YES1 LYN LCK KIT FYN
50	Ephrin B reverse signaling ¹	11.13	YES1 LYN LCK HCK FYN FGR

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GO Terms for Co-Trimoxazole Allergy

Cellular components related to Co-Trimoxazole Allergy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	membrane	GO:0016020	10.28	YES1 SYK PPL PIK3C2A OGA LYN
2	cytoplasm	GO:0005737	10.21	YES1 SYK STAT6 PPL PIK3C2A OGA
3	plasma membrane	GO:0005886	10	YES1 SYK PPL PIK3C2A LYN LCK
4	extracellular exosome	GO:0070062	9.97	YES1 PPL PIK3C2A LYN LCK HSPG2
5	cytosol	GO:0005829	9.8	YES1 SYK STAT6 PPL PIK3C2A OGA
6	membrane raft	GO:0045121	9.73	STAT6 LYN LCK FYN
7	actin filament	GO:0005884	9.63	YES1 HCK FYN
8	mast cell granule	GO:0042629	9.48	LYN KIT
9	extrinsic component of cytoplasmic side of plasma membrane	GO:0031234	9.28	YES1 SYK LYN LCK HCK FYN
10	postsynaptic specialization, intracellular component	GO:0099091	9.26	YES1 LYN

Biological processes related to Co-Trimoxazole Allergy according to GeneCards Suite gene sharing:

(show all 40)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell differentiation	GO:0030154	10.16	YES1 SYK LYN LCK HSPG2 HCK
2	innate immune response	GO:0045087	10.09	YES1 SYK LYN LCK HCK FYN
3	viral process	GO:0016032	10.07	SYK OGA LYN LCK HCK FYN
4	protein phosphorylation	GO:0006468	10.07	YES1 SYK LYN LCK KIT HCK
5	phosphorylation	GO:0016310	10.06	YES1 SYK PIK3C2A LYN LCK KIT
6	intracellular signal transduction	GO:0035556	10.04	SYK LYN KIT FYN BLK
7	cytokine-mediated signaling pathway	GO:0019221	9.97	STAT6 KIT HCK FYN
8	Fc-gamma receptor signaling pathway involved in phagocytosis	GO:0038096	9.95	YES1 SYK LYN HCK FYN FGR
9	protein autophosphorylation	GO:0046777	9.95	YES1 SYK LYN KIT HCK FYN
10	leukocyte migration	GO:0050900	9.93	YES1 LYN LCK FYN
11	regulation of cell shape	GO:0008360	9.92	KIT HCK FYN FGR
12	peptidyl-tyrosine phosphorylation	GO:0018108	9.91	YES1 SYK LYN LCK KIT HCK
13	B cell receptor signaling pathway	GO:0050853	9.88	SYK LYN LCK BLK
14	platelet activation	GO:0030168	9.86	SYK LYN LCK FYN
15	stimulatory C-type lectin receptor signaling pathway	GO:0002223	9.85	SYK LYN FYN
16	integrin-mediated signaling pathway	GO:0007229	9.85	SYK HCK FGR
17	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.85	LYN KIT FYN FGR
18	ephrin receptor signaling pathway	GO:0048013	9.84	YES1 LYN FYN
19	T cell costimulation	GO:0031295	9.84	YES1 LYN LCK FYN
20	hemopoiesis	GO:0030097	9.82	LYN LCK KIT
21	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.82	LYN KIT FYN
22	peptidyl-tyrosine autophosphorylation	GO:0038083	9.81	YES1 SYK LYN LCK HCK FYN
23	positive regulation of phosphatidylinositol 3-kinase activity	GO:0043552	9.75	LYN KIT FGR
24	regulation of defense response to virus by virus	GO:0050690	9.74	LCK HCK FYN
25	regulation of phagocytosis	GO:0050764	9.7	SYK HCK FGR
26	regulation of platelet aggregation	GO:0090330	9.69	SYK LYN BLK
27	negative regulation of B cell proliferation	GO:0030889	9.68	LYN BLK
28	dendritic cell differentiation	GO:0097028	9.67	LYN BLK
29	JAK-STAT cascade involved in growth hormone signaling pathway	GO:0060397	9.67	STAT6 LYN
30	negative regulation of mast cell proliferation	GO:0070667	9.67	LYN ENPP3 BLK
31	regulation of B cell receptor signaling pathway	GO:0050855	9.66	LYN BLK
32	positive regulation of mast cell degranulation	GO:0043306	9.65	SYK FGR
33	regulation of mast cell degranulation	GO:0043304	9.65	LYN BLK
34	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.65	YES1 SYK LYN LCK KIT HCK
35	immune response-regulating cell surface receptor signaling pathway	GO:0002768	9.63	LYN FGR
36	positive regulation of dendritic cell apoptotic process	GO:2000670	9.62	LYN BLK
37	regulation of B cell apoptotic process	GO:0002902	9.61	LYN BLK
38	tolerance induction to self antigen	GO:0002513	9.61	LYN BLK
39	Fc receptor mediated stimulatory signaling pathway	GO:0002431	9.6	LYN BLK
40	regulation of cell proliferation	GO:0042127	9.36	YES1 SYK STAT6 LYN LCK KIT

Molecular functions related to Co-Trimoxazole Allergy according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	transferase activity	GO:0016740	10.2	YES1 SYK PIK3C2A LYN LCK KIT
2	nucleotide binding	GO:0000166	10.17	YES1 SYK PIK3C2A LYN LCK KIT
3	ATP binding	GO:0005524	10.14	YES1 SYK PIK3C2A LYN LCK KIT
4	signaling receptor binding	GO:0005102	9.97	YES1 SYK LYN LCK HCK FYN
5	protein kinase activity	GO:0004672	9.96	YES1 SYK LYN LCK KIT HCK
6	kinase activity	GO:0016301	9.9	YES1 SYK PIK3C2A LYN LCK KIT
7	phosphotyrosine residue binding	GO:0001784	9.77	YES1 SYK LCK HCK FGR
8	ion channel binding	GO:0044325	9.71	YES1 LYN FYN
9	SH2 domain binding	GO:0042169	9.65	SYK LCK KIT
10	non-membrane spanning protein tyrosine kinase activity	GO:0004715	9.61	YES1 SYK LYN LCK HCK FYN
11	phosphatidylinositol 3-kinase binding	GO:0043548	9.55	LCK FYN
12	CD4 receptor binding	GO:0042609	9.52	LCK FYN
13	T cell receptor binding	GO:0042608	9.51	LCK FYN
14	CD8 receptor binding	GO:0042610	9.49	LCK FYN
15	protein tyrosine kinase activity	GO:0004713	9.32	YES1 SYK LYN LCK KIT HCK

Sources

Sources for Co-Trimoxazole Allergy

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia