MCID: CCN002
MIFTS: 51

Cocaine Abuse

Categories: Mental diseases

Aliases & Classifications for Cocaine Abuse

MalaCards integrated aliases for Cocaine Abuse:

Name: Cocaine Abuse 12 55 15 73
Cocaine-Related Disorders 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:809
ICD10 33 F14.1
ICD9CM 35 305.6 305.60
MeSH 44 D019970
SNOMED-CT 68 78267003

Summaries for Cocaine Abuse

Disease Ontology : 12 A substance abuse that involves the recurring use of cocaine despite negative consequences.

MalaCards based summary : Cocaine Abuse, also known as cocaine-related disorders, is related to eating disorder and personality disorder. An important gene associated with Cocaine Abuse is SLC6A3 (Solute Carrier Family 6 Member 3), and among its related pathways/superpathways are Circadian entrainment and Neuroscience. The drugs Cocaine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and placenta, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Cocaine Abuse

Diseases related to Cocaine Abuse via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 eating disorder 30.3 DRD2 SLC6A3 SLC6A4
2 personality disorder 30.0 DRD2 PRL SLC6A3 SLC6A4
3 cocaine dependence 30.0 DBH DRD2 SLC6A3 SLC6A4
4 antisocial personality disorder 29.9 DRD2 SLC6A3 SLC6A4
5 alcohol abuse 29.9 DRD2 PRL SLC6A4
6 substance abuse 29.8 DBH DRD2 PRL SLC6A3 SLC6A4
7 attention deficit-hyperactivity disorder 29.8 DBH DRD2 SLC18A2 SLC6A2 SLC6A3 SLC6A4
8 panic disorder 29.8 HTR3A SLC6A2 SLC6A4
9 conduct disorder 29.7 DBH DRD2 SLC6A3 SLC6A4
10 alcohol dependence 29.7 DBH DRD2 HTR3A SLC6A3 SLC6A4
11 schizophrenia 29.4 DBH DRD2 HTR3A PRL SLC18A2 SLC6A2
12 bipolar disorder 29.0 DBH DRD2 GRK3 HTR3A PRL SLC18A2
13 myocardial infarction 10.4
14 ischemia 10.3
15 thrombosis 10.2
16 vasculitis 10.2
17 galactorrhea 10.2 DRD2 PRL
18 schizophreniform disorder 10.2 DRD2 PRL
19 prolactin producing pituitary tumor 10.2 DRD2 PRL
20 acute myocardial infarction 10.2
21 peripartum cardiomyopathy 10.2 DRD2 PRL
22 periodic limb movement disorder 10.2 DRD2 SLC6A4
23 functioning pituitary adenoma 10.2 DRD2 PRL
24 rem sleep behavior disorder 10.2 SLC6A3 SNCA
25 alexithymia 10.2 DRD2 SLC6A4
26 dilated cardiomyopathy 10.2
27 sinusitis 10.2
28 intermittent explosive disorder 10.2 PRL SLC6A4
29 alcohol-induced mental disorder 10.1 DRD2 SLC6A3 SLC6A4
30 alcoholic psychosis 10.1 DRD2 SLC6A3 SLC6A4
31 amphetamine abuse 10.1 SLC6A2 SLC6A3
32 pathological gambling 10.1 DRD2 SLC6A3 SLC6A4
33 agoraphobia 10.1 SLC6A2 SLC6A4
34 separation anxiety disorder 10.1 PRL SLC6A3
35 sexual disorder 10.1 PRL SLC6A4
36 striatonigral degeneration 10.1 DRD2 SLC6A3 SNCA
37 migraine without aura 10.1 DRD2 PRL SLC6A4
38 substance dependence 10.1 DRD2 SLC6A3 SLC6A4
39 tobacco addiction 10.1 DRD2 SLC6A3 SLC6A4
40 schizoaffective disorder 10.1 DRD2 PRL SLC6A4
41 placental abruption 10.1
42 supranuclear palsy, progressive, 1 10.1 DRD2 SLC6A3 SNCA
43 stuttering 10.1 DBH DRD2 SLC6A3
44 tic disorder 10.1 DRD2 SLC18A2 SLC6A3
45 specific developmental disorder 10.1 SLC6A2 SLC6A3 SLC6A4
46 restless legs syndrome 10.1 DRD2 SLC6A3 SNCA
47 narcolepsy 10.1 DRD2 SLC6A2 SLC6A3
48 premature ejaculation 10.1 HTR3A SLC6A3 SLC6A4
49 fibromyalgia 10.1 HTR3A PRL SLC6A4
50 thrombophilia due to thrombin defect 10.1

Comorbidity relations with Cocaine Abuse via Phenotypic Disease Network (PDN):


Alcohol Abuse

Graphical network of the top 20 diseases related to Cocaine Abuse:



Diseases related to Cocaine Abuse

Symptoms & Phenotypes for Cocaine Abuse

MGI Mouse Phenotypes related to Cocaine Abuse:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.17 CARTPT DBH DRD2 HTR3A PRL SLC17A8
2 homeostasis/metabolism MP:0005376 10.06 BCHE CARTPT DBH DRD2 HTR3A PRL
3 growth/size/body region MP:0005378 10.02 CARTPT DBH DRD2 HTR3A SLC18A2 SLC6A2
4 endocrine/exocrine gland MP:0005379 10.01 CARTPT DBH DRD2 HTR3A PRL SLC6A3
5 integument MP:0010771 9.91 DBH DRD2 HTR3A PRL SLC17A8 SLC6A2
6 mortality/aging MP:0010768 9.81 BCHE DBH DRD2 HTR3A SLC18A2 SLC6A2
7 nervous system MP:0003631 9.65 DBH DRD2 HTR3A PRL SLC17A8 SLC18A2
8 taste/olfaction MP:0005394 9.02 DRD2 GRK3 SLC18A2 SLC6A3 SNCA

Drugs & Therapeutics for Cocaine Abuse

Drugs for Cocaine Abuse (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 159)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cocaine Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 50-36-2 5760 446220
2
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 51-61-6, 62-31-7 681
3
Amphetamine Approved, Illicit, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 300-62-9 5826 3007
4
Risperidone Approved, Investigational Phase 4,Phase 2 106266-06-2 5073
5 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
6 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
7 Central Nervous System Stimulants Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
8 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
9 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
10 Tranquilizing Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
11 Antipsychotic Agents Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1
12 Serotonin Agents Phase 4,Phase 2,Phase 1,Not Applicable
13 Anesthetics, Local Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
14 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
15 Serotonin Antagonists Phase 4,Phase 2,Not Applicable
16 Dopamine Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
17 Dopamine Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
18 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
19 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
20 Adrenergic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
21 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
22 Sympathomimetics Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
23 Quetiapine Fumarate Phase 4,Not Applicable 111974-72-2
24 Dopamine Antagonists Phase 4,Phase 2,Early Phase 1
25
Serotonin Investigational, Nutraceutical Phase 4,Phase 2,Phase 1,Not Applicable 50-67-9 5202
26
Lithium carbonate Approved Phase 3 554-13-2
27
Valproic Acid Approved, Investigational Phase 3 99-66-1 3121
28
Choline Approved, Nutraceutical Phase 3 62-49-7 305
29 Antidepressive Agents Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
30 Cytidine Diphosphate Choline Phase 3
31 Nootropic Agents Phase 3,Phase 2,Not Applicable
32 Antidepressive Agents, Second-Generation Phase 3,Phase 2,Phase 1,Not Applicable
33 adderall Phase 2, Phase 3
34 Anticonvulsants Phase 3,Phase 2,Not Applicable
35 GABA Agents Phase 3,Phase 2
36 Antimanic Agents Phase 3
37
Ethanol Approved Phase 2,Phase 1,Early Phase 1,Not Applicable 64-17-5 702
38
Baclofen Approved Phase 2,Early Phase 1 1134-47-0 2284
39
Ondansetron Approved Phase 2,Not Applicable 99614-02-5 4595
40
Mazindol Approved, Investigational Phase 2 22232-71-9 4020
41
Disulfiram Approved Phase 2,Phase 1 97-77-8 3117
42
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 2,Phase 1 52485-79-7 40400 644073
43
Desipramine Approved, Investigational Phase 2 50-47-5 2995
44
Methadone Approved Phase 2,Phase 1,Not Applicable 76-99-3 4095
45
Fluoxetine Approved, Vet_approved Phase 2 54910-89-3 3386
46
Norepinephrine Approved Phase 2 51-41-2 439260
47
Doxazosin Approved Phase 2,Phase 1 74191-85-8 3157
48
Galantamine Approved Phase 2,Not Applicable 357-70-0 9651
49
Guaifenesin Approved, Investigational, Vet_approved Phase 2,Phase 1,Not Applicable 93-14-1 3516
50
Haloperidol Approved Phase 2 52-86-8 3559

Interventional clinical trials:

(show top 50) (show all 100)
# Name Status NCT ID Phase Drugs
1 Seroquel Therapy for Substance Use Disorders Comorbid With Schizophrenia Completed NCT00208143 Phase 4 Quetiapine;Risperidone
2 Trial of Citicoline Therapy in Patients With Mania or Hypomania and Cocaine Abuse/Dependence Completed NCT00223236 Phase 3 Citicoline;Placebo
3 Effect of Nefazodone on Relapse in Females With Cocaine Abuse - 10 Completed NCT00000293 Phase 3 Nefazodone
4 Study of Adderall-XR for the Treatment of Adult Attention Deficit Hyperactivity Disorder and Cocaine Dependence Completed NCT00553319 Phase 2, Phase 3 Placebo;Adderall-XR;Adderall-XR
5 Lithium and Divalproex for the Treatment of Comorbid Rapid Cycling Bipolar Disorder and Substance Abuse Disorder Completed NCT00194129 Phase 3 Lithium;Divalproex;Placebo
6 Treating Cocaine Abuse: A Behavioral Approach Unknown status NCT01822327 Phase 2
7 Atomoxetine for Treating Cocaine Abuse in Adults With Attention Deficit Hyperactivity Disorder (ADHD) Completed NCT00218543 Phase 2 Atomoxetine
8 Pemoline for Cocaine Abuse - 7 Completed NCT00000282 Phase 2 Pemoline
9 Mazindol for Cocaine Abuse - 2 Completed NCT00000277 Phase 2 Mazindol
10 Disulfiram for Cocaine Abuse in Buprenorphine Treatment Completed NCT00913484 Phase 2 Disulfiram;Placebo
11 Evaluation of a Desipramine Ceiling in Cocaine Abuse - 1 Completed NCT00000245 Phase 2 Desipramine
12 The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual Opioid and Cocaine Abuse - 1 Completed NCT00158288 Phase 2
13 Disulfiram for Cocaine Abuse Completed NCT00395850 Phase 2 Disulfiram
14 Cocaine Abuse and ADHD - 10 Completed NCT00000275 Phase 2 Flupenthixol
15 IV Cocaine Abuse: A Laboratory Model - 4 Completed NCT00000215 Phase 2 Pergolide
16 IV Cocaine Abuse: A Laboratory Model - 3 Completed NCT00000214 Phase 2 Buprenorphine
17 IV Cocaine Abuse: A Laboratory Model - 2 Completed NCT00000213 Phase 2 Fluoxetine
18 IV Cocaine Abuse: A Laboratory Model - 1 Completed NCT00000212 Phase 2 Desipramine
19 Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse Completed NCT01953432 Phase 2 Doxazosin;Placebo
20 New Approaches to Cocaine Abuse Medications (A) - 6 Completed NCT00000271 Phase 2 Desipramine;Placebo
21 Galantamine to Enhance Cognitive Behavioral Therapy for Cocaine Abuse Completed NCT00809835 Phase 2 Galantamine
22 Tryptophan and Behavior Therapy for Cocaine Abuse - 1 Completed NCT00000324 Phase 2 Tryptophan
23 Flupenthixol and Haloperidol for Treating Cocaine Abuse Schizophrenics - 9 Completed NCT00000274 Phase 2 Flupenthixol
24 Disulfiram for Treating Cocaine Dependence in Individuals Maintained on Methadone Completed NCT00218608 Phase 2 Disulfiram
25 Effects of Aripiprazole on Cocaine Craving and Self-Administration Completed NCT00373880 Phase 2 Aripiprazole + Cocaine;Placebo + Cocaine
26 A Randomized, 4-sequence, 2-period, Double-blind, Placebo Controlled Study With a DSM-IV-TR Diagnosis of Cocaine Abuse Completed NCT01846481 Phase 2 RBP-8000 100 mg;Placebo;Cocaine;RBP-8000 200 mg
27 Rapid Evaluation of Baclofen for Treatment of Cocaine Abuse/Dependence - 6 Completed NCT00000303 Phase 2 Baclofen
28 Rapid Evaluation of Amantadine for Treatment of Cocaine Abuse/Dependence - 4 Completed NCT00000301 Phase 2 Amantadine
29 Effectiveness of GABA Agonists in Reducing the Reinforcing Effects of Cocaine Completed NCT00218166 Phase 2 GABA Agonists
30 Medications for Stopping Cocaine Dependence and Preventing Relapse Completed NCT00218023 Phase 2 Modafinil;Levodopa/Carbidopa;Naltrexone HCl;Placebo
31 Use of Donepezil for Treatment of Cocaine Dependence Completed NCT00467389 Phase 2 Donepezil, 5 mg daily
32 Behavioral Therapy Combined With Carbidopa/Levodopa for the Treatment of Cocaine Dependence Completed NCT00218075 Phase 2 Levodopa;Carbidopa
33 Buprenorphine Maintenance for Opioid Addicts - 2 Completed NCT00000203 Phase 2 Buprenorphine
34 Treatment of Cocaine Dependence: Comparison of Three Doses of Dextro-Amphetamine Sulfate and Placebo Completed NCT00218348 Phase 2 Dextro-Amphetamine Sulfate
35 Therapeutic Substance Abuse Treatment in Pregnancy - 1 Completed NCT00227903 Phase 2
36 Modafinil and Naltrexone to Reduce Cocaine and Alcohol Dependence Completed NCT00142818 Phase 2 Naltrexone;Modafinil;Placebo
37 Abstinence-Linked Money Management Multisite Completed NCT01327586 Phase 2
38 Contingency Management for Persons With Severe Mental Illness Completed NCT01478815 Phase 2
39 A Placebo-Controlled Study of Mixed Amphetamine Salts and Topiramate for the Treatment of Cocaine Dependence Completed NCT00421603 Phase 2 Adderall-XR and Topiramate;Placebo
40 Effectiveness of Tiagabine for Cocaine Dependence in Methadone-Maintained Individuals - 1 Completed NCT00129298 Phase 2 Tiagabine
41 New Medication Treatment for Stimulant Dependence Completed NCT00689572 Phase 2 Ondansetron;Placebo
42 Clinical Trial of Abstinence-Linked Money Management Completed NCT00536900 Phase 2
43 Efficacy of N-acetylcysteine on the Craving Symptoms of Abstinent Hospitalized Patients With Cocaine Addiction Not yet recruiting NCT03423667 Phase 2 N-acetylcysteine;Lactose powder
44 Pharmacotherapy Dosing Regimen in Cocaine and Opiate Dependent Individuals - 8 Terminated NCT00218036 Phase 2 Modafinil 200mg;Modafinil 400mg;Citalopram 20mg;Citalopram 40mg;Placebo
45 Serotonin/Dopamine Antagonism of Cocaine Effect: 1 - 1 Terminated NCT00000309 Phase 2 Risperidone
46 Glutaminergic Agents for Cocaine Abuse - 5 Completed NCT00000280 Phase 1 Nimodipine
47 Human Dopamine Transported Imaging in Cocaine Abuse: 2 - 2 Completed NCT00000316 Phase 1 Cocaine
48 Human Dopamine Transported Imaging in Cocaine Abuse: 1 - 1 Completed NCT00000315 Phase 1 Cocaine
49 Methylphenidate Treatment for Cocaine Abuse and ADHD - 1 Completed NCT00136734 Phase 1 Methylphenidate
50 Study to Assess Potential Interactions Between Intravenous Cocaine and Oral Lorcaserin Completed NCT02393599 Phase 1 Lorcaserin;Placebo;Cocaine Infusion

Search NIH Clinical Center for Cocaine Abuse

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: cocaine-related disorders

Genetic Tests for Cocaine Abuse

Anatomical Context for Cocaine Abuse

MalaCards organs/tissues related to Cocaine Abuse:

41
Brain, Testes, Placenta, Lung, Liver, Pituitary, Pancreas

Publications for Cocaine Abuse

Articles related to Cocaine Abuse:

(show top 50) (show all 717)
# Title Authors Year
1
Cocaine abuse: Longitudinal MR imaging of lasting diffused leukoencephalopathy. ( 29400600 )
2018
2
Moyamoya tipping point: fatal bilateral MCA territory infarction following cocaine abuse. ( 29351941 )
2018
3
Mucocutaneous manifestations of cocaine abuse: a review. ( 29512202 )
2018
4
Hypocretin/orexin deficiency decreases cocaine abuse liability. ( 29454841 )
2018
5
Aortic dissection in cocaine abuse: A fatal case. ( 30005338 )
2018
6
From Traumatic Childhood to Cocaine Abuse: The Critical Function of the Immune System. ( 30029767 )
2018
7
Valsalva retinopathy associated with intranasal cocaine abuse: A case report. ( 30207173 )
2018
8
Chemogenetic Manipulations of Ventral Tegmental Area Dopamine Neurons Reveal Multifaceted Roles in Cocaine Abuse. ( 30446532 )
2018
9
Activation of the Immune System During a Developmental Window May Provide a Link Between Early Life Stress and Future Susceptibility to Cocaine Abuse. ( 30466507 )
2018
10
Role of Sigma-1 Receptor in Cocaine Abuse and Neurodegenerative Disease. ( 28315271 )
2017
11
Resting state brain connectivity patterns before eventual relapse into cocaine abuse. ( 28057531 )
2017
12
A tip from the nose: rhinocerebral mucormycosis in a patient with alcoholic liver cirrhosis and cocaine abuse, an uncommon association. ( 28784893 )
2017
13
Chronic orbital inflammatory disease and optic neuropathy associated with long-term intranasal cocaine abuse: 2 cases and literature review. ( 28812909 )
2017
14
Multi-System Complications after Intravenous Cocaine Abuse. ( 28507634 )
2017
15
The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic. ( 28266501 )
2017
16
Impact on Cortical Function of Cocaine Abuse Co-Occurring with HIV. ( 27909321 )
2017
17
Cocaine abuse determination by ion mobility spectrometry using molecular imprinting. ( 28012589 )
2017
18
Quadricuspid Aortic Valve Or a Rare Complication of Cocaine Abuse? ( 29122430 )
2017
19
Botryoid nuclei resulting from cocaine abuse. ( 28439943 )
2017
20
The Use of Intraoperative Transesophageal Echocardiography in Thoracic Aortic Dissection Due to Chronic Cocaine Abuse. ( 28920034 )
2017
21
Cocaine Abuse, Traumatic Brain Injury, and Preexisting Brain Lesions as Risk Factors for Bupropion-Associated Psychosis. ( 28590371 )
2017
22
Towards an automatic lab-on-valve-ion mobility spectrometric system for detection of cocaine abuse. ( 28712550 )
2017
23
Internuclear Ophthalmoplegia Secondary to Cocaine Abuse. ( 28265477 )
2017
24
Heparan sulfate: Resilience factor and therapeutic target for cocaine abuse. ( 29066725 )
2017
25
Increased MFG-E8 expression and its implications in the vascular pathophysiology of cocaine abuse. ( 27182119 )
2016
26
Multiple Pyoderma Gangrenosum Ulcers Associated with Cocaine Abuse. ( 28003907 )
2016
27
The Ventral Pallidum: Proposed Integrator of Positive and Negative Factors in Cocaine Abuse. ( 27710789 )
2016
28
Cocaine abuse and effects in the serum levels of cytokines IL-6 and IL-10. ( 26679059 )
2016
29
Plasma Selenium Levels in Chronic Cocaine Abuse. ( 27349018 )
2016
30
A case of iloperidone overdose in a 27-year-old man with cocaine abuse. ( 27570623 )
2016
31
Relationship between coronary artery ectasia, cocaine abuse and acute coronary syndromes. ( 27231522 )
2016
32
Adolescent d-amphetamine treatment in a rodent model of attention deficit/hyperactivity disorder: impact on cocaine abuse vulnerability in adulthood. ( 27600990 )
2016
33
Multifocal and refractory pyoderma gangrenosum: Possible role of cocaine abuse. ( 27250583 )
2016
34
Cocaine abuse that presents with acute scrotal pain and mimics testicular torsion. ( 27583357 )
2016
35
Behaviour of hygrine and cuscohygrine in illicit cocaine production establishes their use as markers for chewing coca leaves in contrast with cocaine abuse. ( 27004438 )
2016
36
Cocaine Abuse: An Unusual Association. ( 27805341 )
2016
37
Plant expression of cocaine hydrolase-Fc fusion protein for treatment of cocaine abuse. ( 27756365 )
2016
38
Cocaine and crack cocaine abuse by pregnant or lactating mothers and analysis of its biomarkers in meconium and breast milk by LC-MS-A review. ( 26827634 )
2016
39
Extensive Necrotic Purpura in Levamisole-Adulterated Cocaine Abuse - A Case Report. ( 27500987 )
2016
40
Platelet Activation in Human Immunodeficiency Virus Type-1 Patients Is Not Altered with Cocaine Abuse. ( 26076359 )
2015
41
The most dangerous complication of intranasal cocaine abuse in a young man: cardiac arrest. ( 26778640 )
2015
42
Cocaine abuse, retiform purpura and antiphospholipid syndrome. ( 26070938 )
2015
43
Cocaine Abuse in Later Life: A Case Series and Review of the Literature. ( 26445694 )
2015
44
Atraumatic splenic rupture and ileal volvulus following cocaine abuse. ( 26324218 )
2015
45
Effectiveness of secondary prevention and treatment interventions for crack-cocaine abuse: A comprehensive narrative overview of English-language studies. ( 25662894 )
2015
46
The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens. ( 26239290 )
2015
47
Investigating the potential influence of cause of death and cocaine levels on the differential expression of genes associated with cocaine abuse. ( 25658879 )
2015
48
Impact of cocaine abuse on HIV pathogenesis. ( 26539167 )
2015
49
Neuropsychological impairments associated with the relation between cocaine abuse and violence: neurological facilitation mechanisms. ( 25879478 )
2015
50
Assessing cocaine abuse using LC-MS/MS measurements in biological specimens. ( 26168256 )
2015

Variations for Cocaine Abuse

Expression for Cocaine Abuse

Search GEO for disease gene expression data for Cocaine Abuse.

Pathways for Cocaine Abuse

Pathways related to Cocaine Abuse according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 DRD2 GRK3 SLC17A8 SLC18A2 SLC6A3
2 12.16 CARTPT DBH GRK3 SNCA
4 11.81 SLC6A2 SLC6A3 SLC6A4
5
Show member pathways
11.7 DRD2 SLC18A2 SLC6A3
6 11.67 HTR3A SLC18A2 SLC6A4
7
Show member pathways
11.64 SLC17A8 SLC18A2 SLC6A4
8 11.02 SLC6A3 SNCA
9 10.97 SLC18A2 SLC6A3
10 10.88 HTR3A SLC18A2 SLC6A4
11
Show member pathways
10.75 BCHE SLC6A3 SLC6A4
12
Show member pathways
10.56 DBH SLC6A2 SLC6A3 SLC6A4
13 10.49 DBH SLC18A2 SLC6A2

GO Terms for Cocaine Abuse

Cellular components related to Cocaine Abuse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.88 DRD2 HTR3A SLC18A2 SLC6A2 SLC6A3 SLC6A4
2 neuronal cell body GO:0043025 9.76 HTR3A SLC17A8 SLC6A3 SNCA
3 axon GO:0030424 9.73 DRD2 HTR3A SLC6A3 SNCA
4 neuron projection GO:0043005 9.72 HTR3A SLC17A8 SLC6A2 SLC6A3 SLC6A4
5 membrane raft GO:0045121 9.65 SLC6A2 SLC6A3 SLC6A4
6 synaptic vesicle membrane GO:0030672 9.56 DRD2 SLC17A8 SLC18A2 SNCA
7 axon terminus GO:0043679 9.54 DRD2 SLC17A8 SNCA
8 dopaminergic synapse GO:0098691 9.33 DRD2 SLC18A2 SLC6A3
9 integral component of presynaptic membrane GO:0099056 9.26 DRD2 HTR3A SLC6A3 SLC6A4
10 integral component of postsynaptic membrane GO:0099055 8.92 DRD2 HTR3A SLC6A3 SLC6A4

Biological processes related to Cocaine Abuse according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.93 SLC17A8 SLC18A2 SLC6A2 SLC6A3 SLC6A4
2 response to toxic substance GO:0009636 9.77 DRD2 SLC18A2 SLC6A4
3 response to nutrient GO:0007584 9.73 BCHE PRL SLC6A4
4 chemical synaptic transmission GO:0007268 9.73 CARTPT DBH HTR3A SLC18A2 SLC6A2 SNCA
5 response to ethanol GO:0045471 9.71 DRD2 HTR3A PRL SLC6A3
6 excitatory postsynaptic potential GO:0060079 9.7 DRD2 HTR3A SNCA
7 response to drug GO:0042493 9.7 BCHE DRD2 PRL SLC6A2 SLC6A3 SLC6A4
8 locomotory behavior GO:0007626 9.67 DBH DRD2 SLC18A2 SLC6A3
9 positive regulation of multicellular organism growth GO:0040018 9.65 DRD2 SLC6A3
10 associative learning GO:0008306 9.64 DBH DRD2
11 regulation of long-term neuronal synaptic plasticity GO:0048169 9.64 DRD2 SNCA
12 behavioral response to cocaine GO:0048148 9.63 DRD2 SNCA
13 response to pain GO:0048265 9.63 DBH SLC6A2
14 response to iron ion GO:0010039 9.62 DRD2 SLC6A3
15 synaptic transmission, dopaminergic GO:0001963 9.62 DRD2 SNCA
16 response to cocaine GO:0042220 9.62 DRD2 HTR3A SLC6A3 SNCA
17 dopamine metabolic process GO:0042417 9.61 DRD2 SNCA
18 prepulse inhibition GO:0060134 9.61 DRD2 SLC6A3
19 response to amphetamine GO:0001975 9.61 DBH DRD2 SLC18A2
20 neurotransmitter biosynthetic process GO:0042136 9.6 SLC6A3 SLC6A4
21 dopamine biosynthetic process GO:0042416 9.58 SLC6A3 SNCA
22 adenohypophysis development GO:0021984 9.58 DRD2 SLC6A3
23 behavioral response to ethanol GO:0048149 9.57 DBH DRD2
24 dopamine catabolic process GO:0042420 9.55 DBH SLC6A3
25 dopamine transport GO:0015872 9.51 SLC18A2 SLC6A3
26 neurotransmitter loading into synaptic vesicle GO:0098700 9.49 SLC17A8 SLC18A2
27 dopamine uptake involved in synaptic transmission GO:0051583 9.48 SLC6A2 SNCA
28 serotonin uptake GO:0051610 9.46 SLC18A2 SLC6A4
29 neurotransmitter transport GO:0006836 9.35 SLC17A8 SLC18A2 SLC6A2 SLC6A3 SLC6A4
30 monoamine transport GO:0015844 8.92 SLC18A2 SLC6A2 SLC6A3 SLC6A4

Molecular functions related to Cocaine Abuse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 beta-tubulin binding GO:0048487 9.46 SLC6A2 SNCA
2 symporter activity GO:0015293 9.46 SLC17A8 SLC6A2 SLC6A3 SLC6A4
3 alpha-tubulin binding GO:0043014 9.43 SLC6A2 SNCA
4 dopamine binding GO:0035240 9.4 DRD2 SLC6A3
5 serotonin binding GO:0051378 9.37 HTR3A SLC6A4
6 dopamine:sodium symporter activity GO:0005330 9.32 SLC6A2 SLC6A3
7 serotonin:sodium symporter activity GO:0005335 9.26 SLC18A2 SLC6A4
8 neurotransmitter:sodium symporter activity GO:0005328 9.13 SLC6A2 SLC6A3 SLC6A4
9 monoamine transmembrane transporter activity GO:0008504 8.92 SLC18A2 SLC6A2 SLC6A3 SLC6A4

Sources for Cocaine Abuse

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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