MCID: CCN009
MIFTS: 30

Cocaine Intoxication

Categories: Rare diseases

Aliases & Classifications for Cocaine Intoxication

Summaries for Cocaine Intoxication

MalaCards based summary : Cocaine Intoxication is related to substance abuse and metabolic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration. An important gene associated with Cocaine Intoxication is BCHE (Butyrylcholinesterase). Affiliated tissues include kidney, whole blood and brain, and related phenotypes are hyperhidrosis and hypertension

Wikipedia : 73 Cocaine intoxication refers to the subjective and objective, desired and adverse, effects of cocaine on... more...

Related Diseases for Cocaine Intoxication

Diseases related to Cocaine Intoxication via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 substance abuse 29.3 GPT BCHE
2 metabolic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 10.4
3 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.4
4 cocaine abuse 10.3
5 acute kidney failure 10.3
6 kidney disease 10.2
7 ventricular fibrillation, paroxysmal familial, 1 10.1
8 pre-eclampsia 10.1
9 ocular motor apraxia 10.0
10 diabetes mellitus, ketosis-prone 10.0
11 cardiac arrest 10.0
12 aortic dissection 10.0
13 disseminated intravascular coagulation 10.0
14 eclampsia 10.0
15 status epilepticus 10.0
16 subacute delirium 10.0
17 placental abruption 10.0
18 tremor 10.0
19 intussusception 9.9
20 graves disease 1 9.9
21 hepatitis c virus 9.9
22 pulmonary hypertension 9.9
23 brugada syndrome 9.9
24 metabolic acidosis 9.9
25 atrioventricular block 9.9
26 third-degree atrioventricular block 9.9
27 thrombosis 9.9
28 respiratory failure 9.9
29 pulmonary edema 9.9
30 goiter 9.9
31 alcoholic hepatitis 9.9
32 graves' disease 9.9
33 hepatic coma 9.9
34 severe pre-eclampsia 9.9
35 hepatic encephalopathy 9.9
36 hyperglycemia 9.9
37 brain edema 9.9
38 pneumonia 9.9
39 learning disability 9.9
40 cocaine dependence 9.9
41 hypoglycemia 9.9
42 anoxia 9.9
43 cerebral hypoxia 9.9
44 seizure disorder 9.9
45 syncope 9.9
46 acute liver failure 9.9
47 esophageal varix 9.7 GPT BCHE
48 thrombocytopenia 9.6 GPT BCHE
49 body mass index quantitative trait locus 11 9.6 GPT BCHE
50 type 2 diabetes mellitus 9.5 GPT BCHE

Graphical network of the top 20 diseases related to Cocaine Intoxication:



Diseases related to Cocaine Intoxication

Symptoms & Phenotypes for Cocaine Intoxication

Human phenotypes related to Cocaine Intoxication:

58 31 (show top 50) (show all 66)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hyperhidrosis 58 31 frequent (33%) Frequent (79-30%) HP:0000975
2 hypertension 58 31 frequent (33%) Frequent (79-30%) HP:0000822
3 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
4 chest pain 58 31 frequent (33%) Frequent (79-30%) HP:0100749
5 tachycardia 58 31 frequent (33%) Frequent (79-30%) HP:0001649
6 mydriasis 58 31 frequent (33%) Frequent (79-30%) HP:0011499
7 psychotic episodes 58 31 frequent (33%) Frequent (79-30%) HP:0000725
8 paranoia 58 31 frequent (33%) Frequent (79-30%) HP:0011999
9 agitation 58 31 frequent (33%) Frequent (79-30%) HP:0000713
10 mania 58 31 frequent (33%) Frequent (79-30%) HP:0100754
11 proteinuria 58 31 occasional (7.5%) Occasional (29-5%) HP:0000093
12 vomiting 58 31 occasional (7.5%) Occasional (29-5%) HP:0002013
13 myocardial infarction 58 31 occasional (7.5%) Occasional (29-5%) HP:0001658
14 elevated serum creatine kinase 58 31 occasional (7.5%) Occasional (29-5%) HP:0003236
15 supraventricular arrhythmia 58 31 occasional (7.5%) Occasional (29-5%) HP:0005115
16 abdominal pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0002027
17 cough 58 31 occasional (7.5%) Occasional (29-5%) HP:0012735
18 tachypnea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002789
19 pneumothorax 58 31 occasional (7.5%) Occasional (29-5%) HP:0002107
20 pulmonary infiltrates 58 31 occasional (7.5%) Occasional (29-5%) HP:0002113
21 auditory hallucinations 58 31 occasional (7.5%) Occasional (29-5%) HP:0008765
22 pulmonary edema 58 31 occasional (7.5%) Occasional (29-5%) HP:0100598
23 nausea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002018
24 wheezing 58 31 occasional (7.5%) Occasional (29-5%) HP:0030828
25 delirium 58 31 occasional (7.5%) Occasional (29-5%) HP:0031258
26 flank pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0030157
27 pneumomediastinum 58 31 occasional (7.5%) Occasional (29-5%) HP:0025421
28 vivid hallucinations 58 31 occasional (7.5%) Occasional (29-5%) HP:0006803
29 increased lactate dehydrogenase level 31 occasional (7.5%) HP:0025435
30 tremor 58 31 very rare (1%) Very rare (<4-1%) HP:0001337
31 hypotension 58 31 very rare (1%) Very rare (<4-1%) HP:0002615
32 prolonged qt interval 58 31 very rare (1%) Very rare (<4-1%) HP:0001657
33 aortic dissection 58 31 very rare (1%) Very rare (<4-1%) HP:0002647
34 hematuria 58 31 very rare (1%) Very rare (<4-1%) HP:0000790
35 hemoptysis 58 31 very rare (1%) Very rare (<4-1%) HP:0002105
36 gastrointestinal infarctions 58 31 very rare (1%) Very rare (<4-1%) HP:0005244
37 subarachnoid hemorrhage 58 31 very rare (1%) Very rare (<4-1%) HP:0002138
38 cerebral hemorrhage 58 31 very rare (1%) Very rare (<4-1%) HP:0001342
39 coma 58 31 very rare (1%) Very rare (<4-1%) HP:0001259
40 respiratory distress 58 31 very rare (1%) Very rare (<4-1%) HP:0002098
41 tubulointerstitial nephritis 58 31 very rare (1%) Very rare (<4-1%) HP:0001970
42 focal-onset seizure 58 31 very rare (1%) Very rare (<4-1%) HP:0007359
43 acute kidney injury 58 31 very rare (1%) Very rare (<4-1%) HP:0001919
44 colitis 58 31 very rare (1%) Very rare (<4-1%) HP:0002583
45 disseminated intravascular coagulation 58 31 very rare (1%) Very rare (<4-1%) HP:0005521
46 hyperventilation 58 31 very rare (1%) Very rare (<4-1%) HP:0002883
47 glomerulonephritis 58 31 very rare (1%) Very rare (<4-1%) HP:0000099
48 ischemic stroke 58 31 very rare (1%) Very rare (<4-1%) HP:0002140
49 hypovolemia 58 31 very rare (1%) Very rare (<4-1%) HP:0011106
50 ventricular arrhythmia 58 31 very rare (1%) Very rare (<4-1%) HP:0004308

Drugs & Therapeutics for Cocaine Intoxication

Search Clinical Trials , NIH Clinical Center for Cocaine Intoxication

Genetic Tests for Cocaine Intoxication

Anatomical Context for Cocaine Intoxication

MalaCards organs/tissues related to Cocaine Intoxication:

40
Kidney, Whole Blood, Brain, Liver, Heart

Publications for Cocaine Intoxication

Articles related to Cocaine Intoxication:

(show top 50) (show all 283)
# Title Authors PMID Year
1
An improved cocaine hydrolase: the A328Y mutant of human butyrylcholinesterase is 4-fold more efficient. 61 54
9882701 1999
2
The influence of plasma butyrylcholinesterase concentration on the in vitro hydrolysis of cocaine in human plasma. 61 54
9673783 1998
3
Therapeutic use of butyrylcholinesterase for cocaine intoxication. 54 61
9266811 1997
4
Cocaine detoxification by human plasma butyrylcholinesterase. 61 54
9266810 1997
5
Role of Stent Versus Thrombolysis in Management of Cocaine-Induced ST-Elevation Myocardial Infarction. 61
32923253 2020
6
Cocaine and Alcohol Co-Ingestion-Induced Severe Rhabdomyolysis With Acute Kidney Injury Culminating in Hemodialysis-Dependent End-Stage Renal Disease: A Case Report and Literature Review. 61
32676236 2020
7
Substance use disorders: diagnosis and management for hospitalists. 61
32850046 2020
8
[Update - intoxications in critical care medicine]. 61
32018289 2020
9
Brugada syndrome, Brugada phenocopy, or simply arrythmia induced by cocaine intoxication? 61
31909923 2020
10
Protective effects of minocycline, doxycycline and tetracycline on seizure and lethality in a mice cocaine toxicity model. 61
30638629 2019
11
Cocaine Decreases Spontaneous Neuronal Activity and Increases Low-Frequency Neuronal and Hemodynamic Cortical Oscillations. 61
29912298 2019
12
In-Hospital and Long-Term Outcomes of Beta-Blocker Treatment in Cocaine Users: A Systematic Review and Meta-analysis. 61
30834058 2019
13
Surgical care for ingested cocaine packets: Case report and literature review. 61
30716708 2019
14
Lethal Fentanyl and Cocaine Intoxication. 61
30380395 2018
15
A patient full of surprises: a body packer with cocaine intoxication, pneumococcal pneumonia and HIV infection. 61
30180803 2018
16
Death by "Snow"! A Fatal Forensic Case of Cocaine Leakage in a "Drug Mule" on Postmortem Computed and Magnetic Resonance Tomography Compared With Autopsy. 61
28737525 2017
17
Automated segmentation and quantification of OCT angiography for tracking angiogenesis progression. 61
29296491 2017
18
Love Death-A Retrospective and Prospective Follow-Up Mortality Study Over 45 Years. 61
28916405 2017
19
Global cocaine intoxication research trends during 1975-2015: a bibliometric analysis of Web of Science publications. 61
28153037 2017
20
Extensive Necrotic Purpura in Levamisole-Adulterated Cocaine Abuse - A Case Report. 61
27500987 2016
21
Gamma-hydroxybutyrate and cocaine intoxication in a Danish child. 61
27014439 2016
22
Cocaine and benzoylecgonine oral fluid on-site screening and confirmation. 61
26968560 2016
23
An Acute Butyr-Fentanyl Fatality: A Case Report with Postmortem Concentrations. 61
26683128 2016
24
Fatal cocaine intoxication in a body packer. 61
27071289 2016
25
Sudden Cardiac Death of a Body Packer Due to Cocaine Cardiotoxicity. 61
27932899 2016
26
Euglycemic Diabetic Ketoacidosis in a Patient with Cocaine Intoxication. 61
27579186 2016
27
Malignant hypertension-associated thrombotic microangiopathy following cocaine use. 61
26787585 2016
28
Atraumatic splenic rupture and ileal volvulus following cocaine abuse. 61
26324218 2015
29
Sudden Death Due To Acute Cocaine Toxicity-Excited Delirium in a Body Packer. 61
26294349 2015
30
Emotion recognition during cocaine intoxication. 61
26328908 2015
31
Cannabidiol, a Cannabis sativa constituent, inhibits cocaine-induced seizures in mice: Possible role of the mTOR pathway and reduction in glutamate release. 61
26283212 2015
32
Out-of-hospital cardiac arrest after acute cocaine intoxication associated with Brugada ECG patterns: Insights into physiopathologic mechanisms and implications for therapy. 61
26048386 2015
33
Enhancement of endocannabinoid signaling protects against cocaine-induced neurotoxicity. 61
25933444 2015
34
Cardiac depression induced by cocaine or cocaethylene is alleviated by lipid emulsion more effectively than by sulfobutylether-β-cyclodextrin. 61
25908403 2015
35
Bilateral hippocampal stroke secondary to acute cocaine intoxication. 61
26634127 2015
36
Significance of alanine aminotransferase levels in patients admitted for cocaine intoxication. 61
24518798 2015
37
Effects of cocaine-positive urine screens on serum thyrotropin levels in patients admitted to an inpatient mental health unit. 61
25688900 2015
38
Cocaine-induced agitated delirium: a case report and review. 61
24212597 2015
39
Cannabidiol rescues acute hepatic toxicity and seizure induced by cocaine. 61
25999668 2015
40
[The association between cognitive deficits and different outcomes of schizophrenia]. 61
25717480 2014
41
Cocaine Intoxication and Thyroid Storm: Similarity in Presentation and Implications for Treatment. 61
26425625 2014
42
Pretreatment with intravenous lipid emulsion reduces mortality from cocaine toxicity in a rat model. 61
24342818 2014
43
Managing combined critical hypothermia, diabetic ketoacidosis and cocaine intoxication noninvasively. 61
24342869 2014
44
Acute cocaine-related health problems in patients presenting to an urban emergency department in Switzerland: a case series. 61
24666782 2014
45
Cocaine-induced psychotic disorders: presentation, mechanism, and management. 61
25392252 2014
46
A randomized, double-blind, placebo-controlled trial of RBP-8000 in cocaine abusers: pharmacokinetic profile of rbp-8000 and cocaine and effects of RBP-8000 on cocaine-induced physiological effects. 61
25299069 2014
47
Early cannabis use is associated with severity of Cocaine-Induced Psychosis among cocaine smokers in Martinique, French West Indies. 61
24481081 2014
48
Severe chronic hepatitis secondary to prolonged use of ecstasy and cocaine. 61
23910059 2013
49
Chronic cocaine dampens dopamine signaling during cocaine intoxication and unbalances D1 over D2 receptor signaling. 61
24089490 2013
50
Post-mortem cardiac 3-T magnetic resonance imaging: visualization of sudden cardiac death? 61
23563129 2013

Variations for Cocaine Intoxication

Expression for Cocaine Intoxication

Search GEO for disease gene expression data for Cocaine Intoxication.

Pathways for Cocaine Intoxication

GO Terms for Cocaine Intoxication

Molecular functions related to Cocaine Intoxication according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 catalytic activity GO:0003824 8.62 GPT BCHE

Sources for Cocaine Intoxication

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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