Categories: Gastrointestinal diseases, Immune diseases, Infectious diseases

Aliases & Classifications for Coccidiosis

MalaCards integrated aliases for Coccidiosis:

Name: Coccidiosis 12 44 15 17 70
Intestinal Coccidiosis 12
Enteric Coccidiosis 70


External Ids:

Disease Ontology 12 DOID:2113
MeSH 44 D003048
NCIt 50 C34493
SNOMED-CT 67 186125004
UMLS 70 C0009187 C1299919

Summaries for Coccidiosis

Disease Ontology : 12 A parasitic protozoa infectious disease that occurs in the intestinal tract of animals and humans caused by Coccidia protozoa. Immunocompromised persons are at greater risk of developing the infection.

MalaCards based summary : Coccidiosis, also known as intestinal coccidiosis, is related to coccidioidomycosis and cryptosporidiosis. An important gene associated with Coccidiosis is CD4 (CD4 Molecule), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Fluconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include small intestine, skin and bone, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 73 Coccidiosis is a parasitic disease of the intestinal tract of animals caused by coccidian protozoa. The... more...

Related Diseases for Coccidiosis

Diseases related to Coccidiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 913)
# Related Disease Score Top Affiliating Genes
1 coccidioidomycosis 32.6 IL17A CD4 CCR6
2 cryptosporidiosis 32.0 IFNG DHFR CEMP1 CD8A CD4
3 cyclosporiasis 31.8 MT-CYB CD4
4 toxoplasmosis 31.6 TNF MYD88 IL6 IL4 IL1B IL10
5 diarrhea 30.7 TNF IL6 IL2 IL1B IL10 IFNG
6 histoplasmosis 30.6 TNF IFNG CD4 CCR6
7 duodenitis 30.5 TNF CD8A CD4 ALB
8 tracheitis 30.5 TNF IL6 IL1B CD8A
9 cholera 30.4 TNF IL6 IL4 IL1B IL10
10 dysentery 30.3 TNF IL6 IL1B IL10 H2AC18 CD4
11 endometritis 30.3 TNF IL6 IL1B
12 ostertagiasis 30.3 IL10 ALB
13 genital herpes 30.3 IL4 IL10 CD8A CD4 CCR6
14 giardiasis 30.2 IL17A IL10 CD8A CD4 ALB
15 human immunodeficiency virus type 1 30.2 TNF IL2 IL10 IFNG CD4
16 myositis 30.2 TNF IL6 IL2 IL1B IL17A IFNG
17 gastroenteritis 30.1 TNF IL6 IL4 IL1B IL10 IFNG
18 allergic disease 30.1 TNF IL6 IL4 IL2 IL1B IL10
19 bronchopneumonia 30.1 TNF IL6 IL1B IL17A IL10 CD8A
20 myocarditis 30.0 TNF IL6 IL4 IL2 IL1B IL17A
21 meningoencephalitis 30.0 TNF IL6 IL10 CD8A CD4 CCR6
22 acquired immunodeficiency syndrome 30.0 TNF IL6 IL2 IL1B IL10 IFNG
23 tularemia 30.0 TNF MYD88 IL1B IL17A CD8A CD4
24 amebiasis 29.9 TNF IL4 IL1B IL17A IL10 CD4
25 bacterial infectious disease 29.9 TNF MYD88 IL6 IL1B IL17A IL10
26 herpes zoster 29.9 TNF IL2 IL10 IFNG ICOSLG DHFR
27 leishmaniasis 29.8 TNF IL6 IL4 IL2 IL1B IL17A
28 candidiasis 29.8 TNF IL6 IL4 IL2 IL1B IL17A
29 listeriosis 29.7 TNF MYD88 IL6 IL1B IL10 ICOSLG
30 deficiency anemia 29.7 TNF MT-CYB IL6 ICOSLG H2AC18 DHFR
31 bacterial pneumonia 29.6 TNF IL6 IL1B IL17A IL10 ICOSLG
32 dermatitis 29.5 TNF IL6 IL4 IL2 IL1B IL17A
33 fungal infectious disease 29.1 TNF MYD88 IL6 IL4 IL2 IL1B
34 malaria 28.9 TNF MYD88 MT-CYB IL6 IL4 IL2
35 parasitic protozoa infectious disease 28.8 TNF MYD88 MT-CYB IL6 IL4 IL2
36 sarcocystosis 11.0
37 cystoisosporiasis 10.9
38 neurosyphilis 10.6 IL17A IL10
39 punctate inner choroidopathy 10.5 TNF IL10
40 enterocolitis 10.5 TNF IL6 IL10
41 external pathological resorption 10.5 TNF IL6
42 early yaws 10.5 CD8A CD4
43 adult acute lymphocytic leukemia 10.5 CD8A CD4 CCR6
44 1-chloro-2,4-dinitrobenzene allergic contact dermatitis 10.5 IL4 IL2
45 elephantiasis 10.5 IL4 IL10 CD4
46 necrotic uveal melanoma 10.5 IFNG CD8A CD4
47 scorpion envenomation 10.5 TNF IL6
48 riedel's fibrosing thyroiditis 10.5 CD4 ALB
49 type 1 diabetes mellitus 23 10.5 TNF CD8A CD4
50 scabies 10.5 IL10 CD4 CCR6

Graphical network of the top 20 diseases related to Coccidiosis:

Diseases related to Coccidiosis

Symptoms & Phenotypes for Coccidiosis

GenomeRNAi Phenotypes related to Coccidiosis according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 IL10 IL17A IL1B MYD88 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 IL10 IL17A IL1B IL2 MYD88 TNF
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.4 DHFR

MGI Mouse Phenotypes related to Coccidiosis:

# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.22 CCR6 CD4 CD8A DHFR IFNG IL10
2 immune system MP:0005387 10.21 ALB CCR6 CD4 CD8A DHFR IFNG
3 endocrine/exocrine gland MP:0005379 10.17 ALB CD4 CD8A IFNG IL10 IL17A
4 digestive/alimentary MP:0005381 10.16 ALB CD4 IFNG IL10 IL17A IL2
5 integument MP:0010771 10.02 CD4 CD8A DHFR IFNG IL10 IL17A
6 liver/biliary system MP:0005370 9.91 ALB DHFR IFNG IL10 IL2 IL4
7 neoplasm MP:0002006 9.76 ALB IFNG IL10 IL1B IL2 IL6
8 no phenotypic analysis MP:0003012 9.56 CD4 IFNG IL10 IL17A IL2 IL4
9 respiratory system MP:0005388 9.23 IFNG IL10 IL17A IL2 IL4 IL6

Drugs & Therapeutics for Coccidiosis

Drugs for Coccidiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Fluconazole Approved, Investigational Phase 4 86386-73-4 3365
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4 Hormone Antagonists Phase 4
5 Cytochrome P-450 Enzyme Inhibitors Phase 4
6 Hormones Phase 4
7 Anti-Infective Agents Phase 4
8 Antifungal Agents Phase 4
Posaconazole Approved, Investigational, Vet_approved Phase 3 171228-49-2 147912
10 Antiparasitic Agents Phase 3
11 Antiprotozoal Agents Phase 3
Itraconazole Approved, Investigational Phase 2 84625-61-6 55283
13 Vaccines Phase 2
14 Cytochrome P-450 CYP3A Inhibitors Phase 2
Hydroxyitraconazole Phase 2 108222
16 Nikkomycin Phase 1, Phase 2
Methotrexate Approved 1959-05-2, 59-05-2 126941

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 A Randomized, Double-blind, Placebo-controlled Clinical Trial of Fluconazole as Early Empiric Treatment of Coccidioidomycosis Pneumonia (Valley Fever) in Adults Presenting With Community Acquired Pneumonia (CAP) in Endemic Areas (FLEET-Valley Fever) Terminated NCT02663674 Phase 4 Fluconazole
2 A Multicenter, Randomized, Controlled, Double-Blind, Double-Dummy, Two-Arm Study of Posaconazole vs Fluconazole in the Treatment of Coccidioidomycosis Completed NCT00423267 Phase 3 Posaconazole;Fluconazole
3 Safety, Sensitivity and Specificity of Spherule-derived Coccidioidin in Naive Adults, in Adults With a History of Pulmonary Coccidioidomycosis and in Adults With a History of Pulmonary Histoplasmosis Completed NCT00690092 Phase 3
4 Open-Label Study to Evaluate the Efficacy and Safety of SCY-078 (Ibrexafungerp) in Patients With Fungal Diseases That Are Refractory to or Intolerant of Standard Antifungal Treatment (FURI) Recruiting NCT03059992 Phase 3 Ibrexafungerp
5 Safety and Immunogenicity of Live-Attenuated MP-12 Rift Valley Fever Vaccine in Humans, and Genetic Characterization of Virus Isolates Recovered From the Blood of Vaccinated Volunteers: A Phase II Study Completed NCT00415051 Phase 2
6 Parts A&B: Evaluation of the Safety and Immunogenicity of Rift Valley Fever Vaccine, Inactivated, Dried (TSI-GSD 200), A Phase 2 Study Completed NCT00584194 Phase 2
7 A Phase 2 Open Label Safety and Immunogenicity Study of Rift Valley Fever Vaccine, Inactivated, Dried, TSI-GSD 200, Lot 7, Run 2, in Adult Subjects at Risk of Exposure to Rift Valley Fever Virus Recruiting NCT03609398 Phase 2
8 Long-Term Open-Label Primary Vaccination and Booster Dose Study of the Safety and Immunogenicity of Rift Valley Fever Vaccine, Inactivated, Dried (TSI-GSD 200) in At-Risk Adults Active, not recruiting NCT00869713 Phase 2
9 SUBA-Itraconazole Therapy for Coccidioidomycosis Refractory or Intolerant to Fluconazole Not yet recruiting NCT04809649 Phase 2 SUBA-itraconazole
10 Phase I/II Evaluation of the Safety, Pharmacokinetics, and Preliminary Effectiveness of Nikkomycin Z in the Treatment of Patients With Uncomplicated Coccidioides Pneumonia Terminated NCT00614666 Phase 1, Phase 2 nikkomycin Z
11 Sertraline in Addition to Standard of Care Treatment for Coccidioidomycosis Withdrawn NCT02908334 Phase 2 Sertraline
12 A Phase 1, First-In-Human, Randomized, Double-Blind, Placebo-Controlled, Single Dose-Escalation Study to Evaluate the Safety and Pharmacokinetics of Single Oral Doses of VT-1598 in Healthy Adult Subjects Recruiting NCT04208321 Phase 1 VT-1598
13 A Phase I Study to Determine the Safety and Immunogenicity of the Candidate Rift Valley Fever Virus (RVFV) Vaccine ChAdOx1 RVF Among Healthy Adult Volunteers in Uganda Not yet recruiting NCT04672824 Phase 1
14 A Double-Blind, Placebo-Controlled Study of Fluconazole in the Prevention of Active Coccidioidomycosis and Other Systemic Fungal Infections in HIV-Infected Patients Living in the Coccidioidal Endemic Area Completed NCT00002325 Fluconazole
15 Late Outcomes of Rift Valley Fever in Kenya: Ijara Clinical Survey Completed NCT00287014
16 Risk of Coccidioidomycosis in Patients Receiving Anti-TNF and Other Biologic Agents for an Inflammatory Arthritis Completed NCT00796809
17 An Observational Study to Assess the Prevalence and Outcomes of Primary Pulmonary Coccidioidomycosis in Persons Aged > / = 14 Years Presenting With Community Acquired Pneumonia (CAP) in Endemic Areas (SAnds-PPC) Recruiting NCT03908632
18 The Pathogenesis and Genetics of Disseminated or Refractory Coccidiodomycosis Recruiting NCT02190266
19 Improving the Appearance of Skin and Hair in Patients Undergoing Valley Fever Treatment Active, not recruiting NCT03618992
20 A Phase I Study to Determine the Safety & Immunogenicity of the Candidate Rift Valley Fever Virus (RVFV) Vaccine ChAdOx1 RVF in UK Healthy Adult Volunteers Not yet recruiting NCT04754776 Early Phase 1

Search NIH Clinical Center for Coccidiosis

Cochrane evidence based reviews: coccidiosis

Genetic Tests for Coccidiosis

Anatomical Context for Coccidiosis

MalaCards organs/tissues related to Coccidiosis:

Small Intestine, Skin, Bone, Kidney, Breast, T Cells, Eye

Publications for Coccidiosis

Articles related to Coccidiosis:

(show top 50) (show all 2611)
# Title Authors PMID Year
The effects of tributyrin supplementation on weight gain and intestinal gene expression in broiler chickens during Eimeria maxima-induced coccidiosis. 61
33652244 2021
Changes in the ceca microbiota of broilers vaccinated for coccidiosis or supplemented with salinomycin. 61
33684651 2021
Effects of riboflavin and Bacillus subtilis on internal organ development and intestinal health of Ross 708 male broilers with or without coccidial challenge. 61
33588345 2021
Determinants of Eimeria and Campylobacter infection dynamics in UK domestic sheep: the role of co-infection. 61
33541446 2021
Restoration of the sensitivity of Eimeria acervulina to anticoccidial drugs in the chicken following use of a live coccidiosis vaccine. 61
33773363 2021
Effects of administration of an in ovo coccidiosis vaccine at different embryonic ages on vaccine cycling and performance of broiler chickens,. 61
33518328 2021
Concurrent use of saponins and live coccidiosis vaccines: the influence of a quillaja and yucca combination on anticoccidial effects and performance results of coccidia-vaccinated broilers. 61
33518338 2021
The Prevalence and Degree of Endoparasitic Infections in Wild Boars Using the Semi-quantitative Fecal Egg Count Method. 61
32767056 2021
Molecular detection of Eimeria species and Clostridium perfringens in poultry dust and pooled excreta of commercial broiler chicken flocks differing in productive performance. 61
33550163 2021
Anticoccidial effect of Origanum majoranum aqueous extract on Eimeria tenella-infected chicken. 61
33797526 2021
Field evaluation of feeding spray-dried plasma in the starter period on final performance and overall health of broilers. 61
33799116 2021
Transversal gene expression panel to evaluate intestinal health in broiler chickens in different challenging conditions. 61
33737699 2021
Poly (D, L-lactide-co-glycolide) delivery system improve the protective efficacy of recombinant antigen TA4 against Eimeria tenella infection. 61
33799117 2021
Anticoccidial effectivity of a traditional medicinal plant, Cinnamomum verum, in broiler chickens infected with Eimeria tenella. 61
33518353 2021
Molecular characterization and functional analysis of Eimeria tenella citrate synthase. 61
33501586 2021
The structure of a major surface antigen SAG19 from Eimeria tenella unifies the Eimeria SAG family. 61
33742128 2021
Immunological and histopathological evaluation of Eimeria tenella oocysts Egyptian local isolate vaccine and its comparative efficacy with a commercial live vaccine. 61
33797517 2021
Evaluation of immunoprotective effects of recombinant protein and DNA vaccine based on Eimeria tenella surface antigen 16 and 22 in vivo. 61
33689009 2021
Evaluation of 4 merozoite antigens as candidate vaccines against Eimeria tenella infection. 61
33516468 2021
Robenidine Analogues Are Potent Antimalarials in Drug-Resistant Plasmodium falciparum. 61
33724773 2021
Efficacy of the feed additive consisting of decoquinate (Deccox®) for use in chickens for fattening (Zoetis Belgium SA). 61
33732399 2021
Efficacy of the feed additive consisting of amprolium hydrochloride (COXAM®) for use in chickens for fattening and chickens reared for laying (Huvepharma N.V.). 61
33737967 2021
Hulless barley and beta-glucanase levels in the diet affect the performance of coccidiosis-challenged broiler chickens in an age-dependent manner. 61
33518132 2021
Prevalence of Eimeria parasites in the Hubei and Henan provinces of China. 61
33409626 2021
Restoration of anticoccidial sensitivity to a commercial broiler chicken facility in Canada. 61
33518120 2021
Specific EtMIC3-binding peptides inhibit Eimeria tenella sporozoites entry into host cells. 61
33596990 2021
The Modulating Effect of Dietary Beta-Glucan Supplementation on Expression of Immune Response Genes of Broilers during a Coccidiosis Challenge. 61
33445562 2021
Evaluation of sulfadimidine, amprolium and triquen to treat coccidiosis in wild pigeons. 61
33729384 2021
Pharmacokinetics and anticoccidial activity of ethanamizuril in broiler chickens. 61
33249303 2021
Prebiotic supplementation effect on Escherichia coli and Salmonella species associated with experimentally induced intestinal coccidiosis in rabbits. 61
33552731 2021
First report on the prevalence of Klossiella muris in Mus musculus for S. Miguel Island - Azores (Portugal). 61
33678366 2021
Comprehensive Analyses of circRNA Expression Profiles and Function Prediction in Chicken Cecums After Eimeria tenella Infection. 61
33777841 2021
Structural equation models for slaughtering weight prediction for broilers. 61
33389223 2021
Eimeria varia Upton, Campbell, Weigel & McKown, 1990 is a Junior Synonym of Eimeria megabubonis Upton, Campbell, Weigel & McKown, 1990. 61
33387271 2021
Characterization of a novel bacteriophage φCJ22 and its prophylactic and inhibitory effects on necrotic enteritis and Clostridium perfringens in broilers. 61
33357694 2021
Monitoring coccidia in commercial broiler chicken flocks in Ontario: comparing oocyst cycling patterns in flocks using anticoccidial medications or live vaccination. 61
33357673 2021
Activation of ChTLR15/ChNF-κB-ChNLRP3/ChIL-1β signaling transduction pathway mediated inflammatory responses to E. tenella infection. 61
33514434 2021
Impact of Eimeria tenella Oocyst Dose on Parasite Replication, Lesion Score and Cytokine Transcription in the Caeca in Three Breeds of Commercial Layer Chickens. 61
33693044 2021
Molecular characterization of enteric coccidia from domestic ferrets (Mustela putorius furo). 61
33678382 2021
In Vitro Anticoccidial Activities of the Extract and Fractions of Garcinia kola (Heckel h.) against Eimeria tenella Oocyst. 61
33511943 2021
Anti-Coccidial Effect of Rumex Nervosus Leaf Powder on Broiler Chickens Infected with Eimeria Tenella Oocyst. 61
33445749 2021
Eimeria ninakohlyakimovae casts NOX-independent NETosis and induces enhanced IL-12, TNF-α, IL-6, CCL2 and iNOS gene transcription in caprine PMN. 61
33188795 2021
Eimeria tenella: IMP1 protein delivered by Lactococcus lactis induces immune responses against homologous challenge in chickens. 61
33248421 2021
Dietary Application of Tannins as a Potential Mitigation Strategy for Current Challenges in Poultry Production: A Review. 61
33327595 2020
Site-specific delivery of green tea coated aluminium magnesium silicate beads and studies on their effect against chicken coccidiosis. 61
33399104 2020
Analysis of potential risk factors of caprine coccidiosis. 61
33308721 2020
Two Blackhead Disease Outbreaks in Commercial Turkey Flocks Were Potentially Exacerbated by Poor Poult Quality and Coccidiosis. 61
33570098 2020
Therapeutic effect of Moringa oleifera and Thymus vulgaris oils against hepatic coccidiosis in experimentally infected rabbits. 61
33612754 2020
Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target. 61
33297567 2020
Quebracho tannins aid in the control of Eimeria spp. and gastrointestinal nematodes in lambs and goat kids. 61
33171413 2020

Variations for Coccidiosis

Expression for Coccidiosis

Search GEO for disease gene expression data for Coccidiosis.

Pathways for Coccidiosis

Pathways related to Coccidiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Super pathways Score Top Affiliating Genes
Show member pathways
14.12 TNF MYD88 IL6 IL4 IL2 IL1B
Show member pathways
13.87 TNF IL6 IL4 IL2 IL1B IL17A
Show member pathways
13.76 TNF IL6 IL4 IL2 IL1B IL17A
Show member pathways
13.62 TNF IL6 IL4 IL2 IL1B IL17A
Show member pathways
13.53 TNF MYD88 IL6 IL4 IL2 IL1B
Show member pathways
13.47 TNF MYD88 IL6 IL4 IL2 IL1B
Show member pathways
13.41 TNF IL6 IL4 IL2 IL1B IL17A
Show member pathways
13.27 TNF MYD88 IL6 IL2 IL1B IL10
Show member pathways
Show member pathways
12.89 TNF IL6 IL4 IL2 IL1B IL17A
11 12.84 TNF MYD88 IL6 IL1B IFNG
Show member pathways
Show member pathways
12.76 TNF MYD88 IL6 IL2 IL1B
Show member pathways
12.7 TNF IL6 IL2 IL1B IL17A IL10
Show member pathways
12.7 TNF IL6 IL4 IL2 IL1B IL17A
16 12.66 TNF MYD88 IL4 IL2 IL1B IL17A
Show member pathways
12.51 IL6 IL4 IL2 IL10 IFNG
Show member pathways
Show member pathways
Show member pathways
12.45 TNF IL6 IL2 IL10 CCR6
Show member pathways
12.44 TNF MYD88 IL6 IL4 IL2 IL1B
Show member pathways
Show member pathways
Show member pathways
12.39 TNF IL6 IL4 IL2 IL1B IL17A
25 12.38 TNF IL6 IL2 CD4
26 12.37 TNF MYD88 IL6 IL1B IL10 IFNG
Show member pathways
12.35 TNF MYD88 IL6 IL2 IL1B IL10
Show member pathways
29 12.3 TNF MYD88 IL6 IL1B
Show member pathways
12.27 TNF IL1B IFNG H2AC18
31 12.24 TNF IL6 IL1B IL10
32 12.2 ICOSLG CD99 CD8A CD4
33 12.17 TNF IL6 IL4 IL2 IL1B IFNG
34 12.17 TNF MYD88 IL6 IL2 IL1B IL10
35 12.13 TNF IL6 IL4 IL1B IL17A IL10
Show member pathways
12.12 IL4 IL2 IL1B IFNG CD8A CD4
37 12.08 TNF IL6 IL1B IL10 IFNG
38 12.06 TNF IL6 IL4 IL1B CD8A CD4
39 12.03 TNF IL6 IL4 IL2 IL10 IFNG
40 12.02 TNF IL6 IL1B IL17A IFNG
Show member pathways
11.99 IL6 IL4 IL1B IL17A IFNG CD4
42 11.92 IL6 IL4 IL2 IFNG
43 11.92 TNF MYD88 IL6 IL1B IL10
Show member pathways
11.89 TNF IL4 IL2 IFNG
45 11.84 TNF IL6 IL4 IL10 ICOSLG CCR6
Show member pathways
47 11.81 TNF IL6 IL4 IL1B
Show member pathways
11.8 TNF IL6 IL2 IL1B IL17A IL10
Show member pathways
50 11.75 TNF MYD88 IL6 IL1B

GO Terms for Coccidiosis

Cellular components related to Coccidiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 TNF IL6 IL4 IL2 IL1B IL17A
2 extracellular region GO:0005576 9.65 TNF IL6 IL4 IL2 IL1B IL17A
3 external side of plasma membrane GO:0009897 9.1 TNF IL17A ICOSLG CD8A CD4 CCR6

Biological processes related to Coccidiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.21 MYD88 IL2 IL17A ICOSLG CD8A CD4
2 positive regulation of transcription, DNA-templated GO:0045893 10.19 TNF IL6 IL4 IL1B IL10 CD4
3 negative regulation of apoptotic process GO:0043066 10.15 MYD88 IL6 IL4 IL2 IL10 ALB
4 positive regulation of gene expression GO:0010628 10.14 TNF MYD88 IL6 IL4 IL1B IFNG
5 adaptive immune response GO:0002250 10.13 IL2 IL17A IFNG ICOSLG CD8A CD4
6 inflammatory response GO:0006954 10.11 TNF MYD88 IL6 IL1B IL17A
7 positive regulation of protein phosphorylation GO:0001934 10.01 TNF IL2 IL1B IFNG CD4
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.99 TNF MYD88 IL6 IL1B
9 cellular response to lipopolysaccharide GO:0071222 9.97 TNF MYD88 IL6 IL1B IL10
10 positive regulation of DNA-binding transcription factor activity GO:0051091 9.96 TNF IL6 IL1B IL10
11 defense response to Gram-positive bacterium GO:0050830 9.95 TNF MYD88 IL6 IL17A
12 positive regulation of inflammatory response GO:0050729 9.93 TNF IL2 IL1B IFNG
13 positive regulation of tumor necrosis factor production GO:0032760 9.92 MYD88 IL6 IL17A IFNG
14 response to glucocorticoid GO:0051384 9.9 TNF IL6 IL10
15 positive regulation of interferon-gamma production GO:0032729 9.89 TNF IL2 IL1B
16 positive regulation of smooth muscle cell proliferation GO:0048661 9.89 TNF MYD88 IL6
17 positive regulation of cytokine production GO:0001819 9.89 TNF IL10 IFNG
18 regulation of insulin secretion GO:0050796 9.89 TNF IL6 IL1B IFNG
19 positive regulation of phagocytosis GO:0050766 9.87 TNF IL1B IFNG
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.86 TNF IL1B IFNG
21 positive regulation of interleukin-8 production GO:0032757 9.86 TNF MYD88 IL6 IL1B
22 positive regulation of JAK-STAT cascade GO:0046427 9.85 TNF IL6 IL10
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.85 TNF MYD88 IL1B
24 microglial cell activation GO:0001774 9.84 TNF IL4 IFNG
25 humoral immune response GO:0006959 9.84 TNF IL6 IFNG CCR6
26 positive regulation of interleukin-1 beta production GO:0032731 9.83 TNF IL6 IL17A IFNG
27 negative regulation of neurogenesis GO:0050768 9.81 TNF IL6 IL1B
28 positive regulation of osteoclast differentiation GO:0045672 9.8 TNF IL17A IFNG
29 T cell activation GO:0042110 9.8 IL4 ICOSLG CD8A CD4
30 positive regulation of immunoglobulin production GO:0002639 9.79 IL6 IL2 IL10
31 positive regulation of glial cell proliferation GO:0060252 9.78 TNF IL6 IL1B
32 positive regulation of chemokine production GO:0032722 9.78 TNF MYD88 IL6 IFNG
33 positive regulation of interleukin-17 production GO:0032740 9.77 MYD88 IL6 IL2
34 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.77 TNF IL6 IL4 IL2 IFNG
35 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.76 TNF IL1B IFNG
36 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.75 TNF IL1B IL10
37 regulation of establishment of endothelial barrier GO:1903140 9.73 TNF IL1B
38 negative regulation of T-helper 17 cell differentiation GO:2000320 9.73 IL4 IL2
39 positive regulation of isotype switching to IgG isotypes GO:0048304 9.73 IL4 IL2
40 negative regulation of lipid storage GO:0010888 9.73 TNF IL6
41 endothelial cell apoptotic process GO:0072577 9.72 TNF IL10
42 response to peptidoglycan GO:0032494 9.72 MYD88 IL6
43 positive regulation of neuroinflammatory response GO:0150078 9.72 TNF IL6 IL1B
44 positive regulation of mononuclear cell migration GO:0071677 9.71 TNF IL4
45 negative regulation of cytokine production involved in immune response GO:0002719 9.71 TNF IL10
46 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.71 TNF MYD88 IL6 IL17A
47 positive regulation of cellular respiration GO:1901857 9.7 IL4 IFNG
48 neuroinflammatory response GO:0150076 9.7 IL4 IFNG
49 type 2 immune response GO:0042092 9.7 IL4 IL10
50 positive regulation of fever generation GO:0031622 9.7 TNF IL1B

Molecular functions related to Coccidiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 IL6 IL4 IL2 IL10
2 cytokine activity GO:0005125 9.23 TNF IL6 IL4 IL2 IL1B IL17A

Sources for Coccidiosis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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