MCID: CCC002
MIFTS: 51

Coccidiosis

Categories: Gastrointestinal diseases, Immune diseases, Infectious diseases

Aliases & Classifications for Coccidiosis

MalaCards integrated aliases for Coccidiosis:

Name: Coccidiosis 12 43 15 17 71
Intestinal Coccidiosis 12
Enteric Coccidiosis 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2113
MeSH 43 D003048
NCIt 49 C34493
SNOMED-CT 67 62005008
UMLS 71 C0009187 C1299919

Summaries for Coccidiosis

Disease Ontology : 12 A parasitic protozoa infectious disease that occurs in the intestinal tract of animals and humans caused by Coccidia protozoa. Immunocompromised persons are at greater risk of developing the infection.

MalaCards based summary : Coccidiosis, also known as intestinal coccidiosis, is related to coccidioidomycosis and cryptosporidiosis. An important gene associated with Coccidiosis is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Fluconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Coccidiosis is a parasitic disease of the intestinal tract of animals caused by coccidian protozoa. The... more...

Related Diseases for Coccidiosis

Diseases related to Coccidiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 918)
# Related Disease Score Top Affiliating Genes
1 coccidioidomycosis 33.1 TNF TLR4 CD40LG CD4 CCR6
2 cryptosporidiosis 33.0 IFNG DHFR CEMP1 CD8A CD40LG CD4
3 toxoplasmosis 32.1 TNF TLR4 TLR2 MYD88 IL6 IL4
4 diarrhea 31.3 TNF TLR4 IL6 IL2 IL1B IL10
5 intussusception 31.0 IL6 CD40LG ALB
6 duodenitis 30.9 TNF CD8A CD40LG CD4 ALB
7 hypereosinophilic syndrome 30.9 IL4 IL2 IL10 IFNG
8 histoplasmosis 30.9 TNF IFNG CD8A CD40LG CD4 CCR6
9 myositis 30.8 TNF IL6 IL1B IFNG ICOSLG
10 giardiasis 30.8 CD8A CD40LG CD4 ALB
11 cholera 30.8 TNF IL6 IL4 IL1B
12 allergic hypersensitivity disease 30.6 TNF IL4 IL2 IL10 IFNG ICOSLG
13 human immunodeficiency virus type 1 30.6 TNF IL2 IL10 IFNG CD4
14 deficiency anemia 30.6 TNF IL6 H2AC18 ALB
15 encephalitis 30.6 TNF TLR2 IL6 IL4 IL1B IL10
16 constipation 30.5 TNF IL6 H2AC18 ALB
17 endometritis 30.5 TNF TLR4 TLR2 IL6 IL1B
18 gastroenteritis 30.5 TNF IL6 IL4 IL1B IL10 IFNG
19 genital herpes 30.4 TLR2 IL4 IL10 CD8A CD40LG CD4
20 intestinal disease 30.3 TNF TLR4 IL6 IL1B IL10 ICOSLG
21 bronchopneumonia 30.3 TNF TLR4 IL6 IL1B IL10 CD8A
22 myocarditis 30.2 TNF TLR4 IL6 IL4 IL2 IL1B
23 dysentery 30.2 TNF TLR4 TLR2 IL6 IL1B IL10
24 dermatitis 30.2 TNF IL6 IL4 IL2 IL1B IL10
25 acquired immunodeficiency syndrome 30.2 TNF IL6 IL2 IL1B IL10 IFNG
26 amebiasis 30.1 TNF TLR4 TLR2 IL4 IL1B CD40LG
27 tularemia 30.0 TNF TLR4 TLR2 MYD88 IL1B CD8A
28 neutropenia 30.0 TNF TLR4 IL6 IL2 IL1B IL10
29 meningoencephalitis 30.0 TNF IL6 IL4 IL1B IL10 CD8A
30 herpes zoster 29.9 TNF TLR2 IL2 IL10 IFNG ICOSLG
31 immune deficiency disease 29.8 TNF TLR2 IL6 IL4 IL2 IL10
32 candidiasis 29.7 TNF TLR4 TLR2 IL6 IL4 IL2
33 bacterial infectious disease 29.6 TNF TLR4 TLR2 MYD88 IL6 IL1B
34 leishmaniasis 29.6 TNF TLR4 TLR2 MYD88 IL6 IL4
35 bacterial pneumonia 29.5 TNF TLR4 TLR2 IL6 IL1B IL10
36 listeriosis 29.5 TNF TLR4 TLR2 MYD88 IL6 IL2
37 fungal infectious disease 29.1 TNF TLR4 TLR2 IL6 IL4 IL2
38 malaria 28.8 TNF TLR4 TLR2 MYD88 IL6 IL4
39 parasitic protozoa infectious disease 28.7 TNF TLR4 TLR2 MYD88 IL6 IL4
40 sarcocystosis 11.5
41 cyclosporiasis 11.2
42 cystoisosporiasis 11.2
43 neurosyphilis 10.7 TLR2 IL10
44 punctate inner choroidopathy 10.7 TNF IL10
45 brawny scleritis 10.7 IFNG CD40LG
46 early yaws 10.7 CD8A CD40LG CD4
47 necrotic uveal melanoma 10.7 IFNG CD8A
48 adult acute lymphocytic leukemia 10.7 CD8A CD4 CCR6
49 external pathological resorption 10.7 TNF IL6
50 norwegian scabies 10.7 CD8A CD40LG CD4

Graphical network of the top 20 diseases related to Coccidiosis:



Diseases related to Coccidiosis

Symptoms & Phenotypes for Coccidiosis

GenomeRNAi Phenotypes related to Coccidiosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.36 CD40LG IL10 IL1B MYD88 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.36 IL10 IL1B IL2 MYD88 TNF
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.36 DHFR

MGI Mouse Phenotypes related to Coccidiosis:

45 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.4 ALB CD4 CD40LG CD8A DHFR IFNG
2 hematopoietic system MP:0005397 10.4 CCR6 CD4 CD40LG CD8A DHFR IFNG
3 immune system MP:0005387 10.4 ALB CCR6 CD4 CD40LG CD8A DHFR
4 homeostasis/metabolism MP:0005376 10.39 ALB CCR6 CD4 CD40LG DHFR IFNG
5 cardiovascular system MP:0005385 10.38 ALB CCR6 CD40LG DHFR IFNG IL10
6 endocrine/exocrine gland MP:0005379 10.31 ALB CD4 CD40LG CD8A IFNG IL10
7 mortality/aging MP:0010768 10.31 ALB CD4 CD40LG CD8A DHFR IFNG
8 digestive/alimentary MP:0005381 10.29 ALB CD4 IFNG IL10 IL2 IL4
9 integument MP:0010771 10.26 CD4 CD40LG CD8A DHFR IFNG IL10
10 liver/biliary system MP:0005370 10.2 ALB DHFR IFNG IL10 IL2 IL4
11 nervous system MP:0003631 10.13 CCR6 CD4 CD40LG CD8A IFNG IL10
12 neoplasm MP:0002006 10.07 ALB IFNG IL10 IL1B IL2 IL6
13 muscle MP:0005369 10.01 ALB DHFR IFNG IL10 IL6 TLR2
14 normal MP:0002873 9.91 ALB CCR6 CD4 CD8A IFNG IL10
15 renal/urinary system MP:0005367 9.81 ALB CD40LG CD8A IFNG IL4 IL6
16 respiratory system MP:0005388 9.61 IFNG IL10 IL2 IL4 IL6 MYD88
17 skeleton MP:0005390 9.32 CD40LG IFNG IL10 IL1B IL4 IL6

Drugs & Therapeutics for Coccidiosis

Drugs for Coccidiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved, Investigational Phase 4 86386-73-4 3365
2
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4 Cytochrome P-450 Enzyme Inhibitors Phase 4
5 Hormone Antagonists Phase 4
6 Hormones Phase 4
7 Anti-Infective Agents Phase 4
8 Antifungal Agents Phase 4
9
Posaconazole Approved, Investigational, Vet_approved Phase 3 171228-49-2 147912
10 Antiprotozoal Agents Phase 3
11 Antiparasitic Agents Phase 3
12 Vaccines Phase 2
13 Nikkomycin Phase 1, Phase 2
14
Methotrexate Approved 59-05-2, 1959-05-2 126941

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 A Randomized, Double-blind, Placebo-controlled Clinical Trial of Fluconazole as Early Empiric Treatment of Coccidioidomycosis Pneumonia (Valley Fever) in Adults Presenting With Community Acquired Pneumonia (CAP) in Endemic Areas (FLEET-Valley Fever) Terminated NCT02663674 Phase 4 Fluconazole
2 A Multicenter, Randomized, Controlled, Double-Blind, Double-Dummy, Two-Arm Study of Posaconazole vs Fluconazole in the Treatment of Coccidioidomycosis Completed NCT00423267 Phase 3 Posaconazole;Fluconazole
3 Safety, Sensitivity and Specificity of Spherule-derived Coccidioidin in Naive Adults, in Adults With a History of Pulmonary Coccidioidomycosis and in Adults With a History of Pulmonary Histoplasmosis Completed NCT00690092 Phase 3
4 Open-Label Study to Evaluate the Efficacy and Safety of SCY-078 (Ibrexafungerp) in Patients With Fungal Diseases That Are Refractory to or Intolerant of Standard Antifungal Treatment (FURI) Recruiting NCT03059992 Phase 3 Ibrexafungerp
5 Bridging Safety & Immunogenicity Study of GSK Biologicals' Candidate Malaria Vaccine RTS,S/AS01E (0.5 mL Dose) to RTS,S/AS02D (0.5 mL Dose) Administered IM According to a 0, 1, 2-Month Schedule in Gabonese Children Aged 18 Months to 4 Years Completed NCT00307021 Phase 2
6 Parts A&B: Evaluation of the Safety and Immunogenicity of Rift Valley Fever Vaccine, Inactivated, Dried (TSI-GSD 200), A Phase 2 Study Completed NCT00584194 Phase 2
7 A Phase IIb Randomized, Double-blind, Controlled Study of the Safety, Immunogenicity and Proof-of-concept of RTS,S/AS02D, a Candidate Malaria Vaccine, When Incorporated Into an Expanded Program on Immunization (EPI) Regimen That Includes DTPw/Hib in Infants Living in a Malaria-endemic Region. Completed NCT00289185 Phase 2
8 Safety and Immunogenicity of Live-Attenuated MP-12 Rift Valley Fever Vaccine in Humans, and Genetic Characterization of Virus Isolates Recovered From the Blood of Vaccinated Volunteers: A Phase II Study Completed NCT00415051 Phase 2
9 A Phase 2 Open Label Safety and Immunogenicity Study of Rift Valley Fever Vaccine, Inactivated, Dried, TSI-GSD 200, Lot 7, Run 2, in Adult Subjects at Risk of Exposure to Rift Valley Fever Virus Recruiting NCT03609398 Phase 2
10 Long-Term Open-Label Primary Vaccination and Booster Dose Study of the Safety and Immunogenicity of Rift Valley Fever Vaccine, Inactivated, Dried (TSI-GSD 200) in At-Risk Adults Active, not recruiting NCT00869713 Phase 2
11 Phase I/II Evaluation of the Safety, Pharmacokinetics, and Preliminary Effectiveness of Nikkomycin Z in the Treatment of Patients With Uncomplicated Coccidioides Pneumonia Terminated NCT00614666 Phase 1, Phase 2 nikkomycin Z
12 Sertraline in Addition to Standard of Care Treatment for Coccidioidomycosis Withdrawn NCT02908334 Phase 2 Sertraline
13 A Phase 1, First-In-Human, Randomized, Double-Blind, Placebo-Controlled, Single Dose-Escalation Study to Evaluate the Safety and Pharmacokinetics of Single Oral Doses of VT-1598 in Healthy Adult Subjects Recruiting NCT04208321 Phase 1 VT-1598
14 Risk of Coccidioidomycosis in Patients Receiving Anti-TNF and Other Biologic Agents for an Inflammatory Arthritis Completed NCT00796809
15 A Double-Blind, Placebo-Controlled Study of Fluconazole in the Prevention of Active Coccidioidomycosis and Other Systemic Fungal Infections in HIV-Infected Patients Living in the Coccidioidal Endemic Area Completed NCT00002325 Fluconazole
16 Late Outcomes of Rift Valley Fever in Kenya: Ijara Clinical Survey Completed NCT00287014
17 The Pathogenesis and Genetics of Disseminated or Refractory Coccidiodomycosis Recruiting NCT02190266
18 An Observational Study to Assess the Prevalence and Outcomes of Primary Pulmonary Coccidioidomycosis in Persons Aged > / = 14 Years Presenting With Community Acquired Pneumonia (CAP) in Endemic Areas (SAnds-PPC) Recruiting NCT03908632
19 Improving the Appearance of Skin and Hair in Patients Undergoing Valley Fever Treatment Active, not recruiting NCT03618992
20 Study of Patients With Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Coccidiosis

Cochrane evidence based reviews: coccidiosis

Genetic Tests for Coccidiosis

Anatomical Context for Coccidiosis

MalaCards organs/tissues related to Coccidiosis:

40
Liver, Small Intestine, Testes, T Cells, Skin, Colon, Kidney

Publications for Coccidiosis

Articles related to Coccidiosis:

(show top 50) (show all 2469)
# Title Authors PMID Year
1
Usefulness of PCR-RFLP of 18S rRNA gene for rapid post-mortem diagnostics of highly pathogenic Eimeria spp. (Apicomplexa: Eimeriidae) of European bison, Bison bonasus L. with histopathological correlation. 61
32368487 2020
2
Synergistic effect of a combination of nicarbazin and monensin against coccidiosis in the chicken caused by Eimeria spp. 61
32310002 2020
3
Effects of Goussia infecting the blue whiting and phylogenetic placement of Goussia infecting marine fish off Northern Portugal. 61
32476061 2020
4
Influence of Eimeria spp. Infection on Chicken Jejunal Microbiota and the Efficacy of Two Alternative Products Against the Infection. 61
32550611 2020
5
Recombinant ubiquitin-conjugating enzyme of Eimeria maxima induces immunogenic maturation in chicken splenic-derived dendritic cells and drives Th1 polarization in-vitro. 61
32194180 2020
6
The effect of a Local isolate and Houghton strain of Eimeria tenella on clinical and growth parameters following challenge in chickens vaccinated with IMMUCOX® and LIVACOX® vaccines. 61
32508414 2020
7
A potential vaccine candidate towards chicken coccidiosis mediated by recombinant Lactobacillus plantarum with surface displayed EtMIC2 protein. 61
32525007 2020
8
Recombinant invasive Lactobacillus plantarum expressing the Eimeria tenella fusion gene TA4 and AMA1 induces protection against coccidiosis in chickens. 61
32526607 2020
9
The anticoccidial activity of the fluoroquinolone lomefloxacin against experimental Eimeria tenella infection in broiler chickens. 61
32399722 2020
10
The effect of heated floor on the outcome coccidiosis in broilers. 61
32508421 2020
11
Correlation between intestinal health and coccidiosis prevalence in broilers in Brazilian agroindustries. 61
31756388 2020
12
Immune response and protective efficacy of recombinant Enterococcus faecalis displaying dendritic cell-targeting peptide fused with Eimeria tenella 3-1E protein. 61
32475431 2020
13
Body condition and poxvirus infection predict circulating glucose levels in a colorful songbird that inhabits urban and rural environments. 61
32515908 2020
14
Incidence and associated risk factors of necrotic enteritis in Belgian layer pullet flocks. 61
32441575 2020
15
Efficacy of dietary supplemental insoluble fibrous materials in ameliorating adverse effects of coccidial challenge in broiler chickens. 61
32551890 2020
16
The influence of indigestible protein on broiler digestive tract morphology and caecal protein fermentation metabolites. 61
31854098 2020
17
The effects of trace narasin on the biogeochemical N-cycle in a cultivated sandy loam. 61
32036138 2020
18
Efficacy of probiotic Enterococcus faecium in combination with diclazuril against coccidiosis in experimentally infected broilers. 61
32364304 2020
19
Transgenic Eimeria parasite: A potential control strategy for chicken coccidiosis. 61
32105666 2020
20
Effect of arginine supplementation on growth performance, lipid profile, and inflammatory responses of broiler chicks challenged with coccidiosis. 61
32460155 2020
21
Effect of diet supplemented with coconut essential oil on performance and villus histomorphology in broiler exposed to avian coccidiosis. 61
32377969 2020
22
Population pharmacokinetics of ethanamizuril in normal and coccidiosis-infected chickens through ultra-performance liquid chromatography-Tandem Mass Spectrometry. 61
32374465 2020
23
Effects of Eimeria maxima and Clostridium perfringens infections on cecal microbial composition and the possible correlation with body weight gain in broiler chickens. 61
32575030 2020
24
Hepatic Coccidiosis in Triportheus angulatus Spix & Agassiz, 1829 (Characiformes: Triportheidae), a Tropical Fish from the Eastern Brazilian Amazon, with the Description of a New Species of Calyptospora (Apicomplexa: Calyptosporidae). 61
31943507 2020
25
Anticoccidial effects of Khaya senegalensis aqueous stem bark extract on broiler chickens experimentally infected with Eimeria species. 61
32006232 2020
26
Anticoccidial and Antioxidant Activities of Moringa oleifera Leaf Extract on Murine Intestinal Eimeriosis. 61
32472400 2020
27
Microwave method synthesis of magnetic ionic liquid/gold nanoparticles as ultrasensitive SERS substrates for trace clopidol detection. 61
32215690 2020
28
Micro-RNA expression profile of chicken small intestines during Eimeria necatrix infection. 61
32359579 2020
29
Molecular characterization of serine/threonine protein phosphatase of Eimeria tenella. 61
32358794 2020
30
The efficacy of toltrazuril treatment for reducing the infection intensity of Theileria orientalis Ikeda type in dairy calves. 61
32442844 2020
31
A study on risk factors for macroscopic gut abnormalities in intensively reared broiler chickens. 61
31899945 2020
32
A Data-Driven Prediction Method for an Early Warning of Coccidiosis in Intensive Livestock Systems: A Preliminary Study. 61
32344716 2020
33
COCCIDIOSIS IN GREEN TURTLES (CHELONIA MYDAS) IN AUSTRALIA: PATHOGENESIS, SPATIAL AND TEMPORAL DISTRIBUTION, AND CLIMATE-RELATED DETERMINANTS OF DISEASE OUTBREAKS. 61
31658432 2020
34
HPLC semi-preparative separation of diclazuril enantiomers and racemization in solution. 61
31909564 2020
35
A modified method for purification of Eimeria tenella sporozoites. 61
31942639 2020
36
Study of the Relationship between Polymorphisms in the IL-8 Gene Promoter Region and Coccidiosis Resistance Index in Jinghai Yellow Chickens. 61
32349370 2020
37
Towards Innovative Design and Application of Recombinant Eimeria as a Vaccine Vector. 61
32094255 2020
38
Changes in the corticosterone level in tooting male black grouse (Tetrao tetrix) infected with Eimeria spp. 61
31956072 2020
39
Thymol efficacy against coccidiosis in pigeon (Columba livia domestica). 61
32066028 2020
40
Ruminant Coccidiosis. 61
32029184 2020
41
Dietary Encapsulated Essential Oils Improve Production Performance of Coccidiosis-Vaccine-Challenged Broiler Chickens. 61
32183035 2020
42
Diagnosis of sub-clinical coccidiosis in fast growing broiler chickens by MicroRNA profiling. 61
32198064 2020
43
Effects of Eimeria tenella infection on the barrier damage and microbiota diversity of chicken cecum. 61
32111306 2020
44
Research Note: Correlation analysis of interleukin-6, interleukin-8, and C-C motif chemokine ligand 2 gene expression in chicken spleen and cecal tissues after Eimeria tenella infection in vivo. 61
32115023 2020
45
First database of the spatial distribution of Eimeria species of cattle, sheep and goats in Mexico. 61
31901110 2020
46
The role of high-grade Bentonite powder in coccidiosis and its effects on feed conversion ratio and blood parameters in broiler chicken. 61
32233292 2020
47
Evaluation of nitro compounds as feed additives in diets of Eimeria-challenged broilers in vitro and in vivo. 61
32111308 2020
48
Molecular characterization and immune protection of an AN1-like zinc finger protein of Eimeria tenella. 61
31758298 2020
49
Immunoproteomic and mass spectrometric analysis of Eimeria acervulina antigens recognized by antisera from chickens infected with E. acervulina, E. tenella or E. necatrix. 61
32085718 2020
50
Correction to: Oral inoculation of ultraviolet-irradiated Eimeria species oocysts protects chickens against coccidiosis. 61
31901108 2020

Variations for Coccidiosis

Expression for Coccidiosis

Search GEO for disease gene expression data for Coccidiosis.

Pathways for Coccidiosis

Pathways related to Coccidiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.14 TNF TLR4 TLR2 MYD88 IL6 IL4
2
Show member pathways
13.81 TNF TLR4 IL6 IL4 IL2 IL1B
3
Show member pathways
13.6 TNF IL6 IL4 IL2 IL1B IL10
4
Show member pathways
13.54 TNF TLR4 TLR2 MYD88 IL6 IL4
5
Show member pathways
13.5 TNF MYD88 IL6 IL4 IL2 IL1B
6
Show member pathways
13.44 TNF IL6 IL4 IL2 IL1B IL10
7
Show member pathways
13.34 TNF TLR4 TLR2 MYD88 IL4 IL2
8
Show member pathways
13.2 TNF TLR4 TLR2 MYD88 IL6 IL2
9
Show member pathways
13.08 TNF TLR4 TLR2 MYD88 IL6 IL1B
10
Show member pathways
13.07 TNF TLR4 TLR2 IL6 IL4 IL2
11
Show member pathways
12.97 TNF TLR4 TLR2 MYD88 IL6 IL2
12
Show member pathways
12.96 TNF IL6 IL4 IL2 IL1B IL10
13 12.92 TNF TLR2 MYD88 IL6 IL1B IFNG
14
Show member pathways
12.88 TNF TLR4 TLR2 MYD88 IL6 IL2
15
Show member pathways
12.86 TNF TLR4 TLR2 MYD88 IL6 IL1B
16
Show member pathways
12.81 TNF IL4 IL2 IL10 IFNG ICOSLG
17
Show member pathways
12.76 TNF IL6 IL2 IL1B IL10 IFNG
18
Show member pathways
12.75 TNF IL1B IFNG CD40LG CD4
19
Show member pathways
12.74 TNF TLR4 TLR2 MYD88 IL1B CD40LG
20
Show member pathways
12.73 TNF TLR4 TLR2 IL6 IL4 IL2
21 12.65 TNF TLR2 MYD88 IL4 IL2 IL1B
22
Show member pathways
12.55 IL6 IL4 IL2 IL10 IFNG
23
Show member pathways
12.51 TNF TLR2 IL6 IL4 IL1B IFNG
24
Show member pathways
12.5 TNF IL6 IL4 IL2 IL1B IFNG
25
Show member pathways
12.48 TNF IL6 IL2 IL10 CCR6
26
Show member pathways
12.48 TNF TLR4 MYD88 IL6 IL1B IFNG
27 12.48 TNF TLR4 TLR2 MYD88 IL6 IL1B
28
Show member pathways
12.44 TNF IL6 IL4 IL2 IL1B IL10
29 12.42 TNF TLR4 MYD88 IL6 IL1B
30
Show member pathways
12.42 TNF TLR4 TLR2 MYD88 IL6
31 12.4 TNF IL6 IL2 CD4
32 12.4 TNF TLR4 TLR2 MYD88 IL6 IL1B
33 12.39 TNF TLR4 MYD88 IL6 IL1B
34
Show member pathways
12.39 TNF MYD88 IL6 IL2 IL1B IL10
35
Show member pathways
12.36 TNF TLR4 IL1B IFNG H2AC18
36 12.35 TNF TLR4 TLR2 IL6 IFNG
37
Show member pathways
12.33 TNF TLR4 TLR2 MYD88 IL6 IL4
38
Show member pathways
12.33 TNF TLR4 TLR2 MYD88 IL4 IL1B
39 12.29 ICOSLG CD99 CD8A CD40LG CD4
40 12.27 TNF IL6 IL1B IL10
41 12.21 TNF TLR4 MYD88 IL6 IL2 IL1B
42 12.2 TNF TLR4 IL6 IL4 IL2 IL1B
43
Show member pathways
12.17 IL4 IL2 IL1B IFNG CD8A CD4
44 12.16 TNF IL6 IL4 IL1B IL10
45
Show member pathways
12.15 TLR4 TLR2 IL2 IL1B
46 12.12 TNF TLR4 MYD88 IL1B CD40LG
47 12.12 TNF IL6 IL4 IL2 IL10 IFNG
48 12.11 TNF IL6 IL4 IL1B CD8A CD4
49 12.11 TNF TLR4 TLR2 IL6 IL1B IL10
50 12.07 TNF TLR4 TLR2 IL6 IL1B IFNG

GO Terms for Coccidiosis

Cellular components related to Coccidiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.86 TNF TLR4 TLR2 CD99 CD8A CD40LG
2 extracellular region GO:0005576 9.85 TNF IL6 IL4 IL2 IL1B IL10
3 cell surface GO:0009986 9.8 TNF TLR4 TLR2 CD40LG CD4 CCR6
4 extracellular space GO:0005615 9.61 TNF IL6 IL4 IL2 IL1B IL10
5 external side of plasma membrane GO:0009897 9.17 TNF TLR4 ICOSLG CD8A CD40LG CD4

Biological processes related to Coccidiosis according to GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.36 TLR4 TLR2 MYD88 IL6 IL4 IL1B
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.3 TNF TLR4 TLR2 IL6 IL4 IL2
3 immune system process GO:0002376 10.24 TLR4 TLR2 MYD88 IL2 ICOSLG CD8A
4 positive regulation of transcription, DNA-templated GO:0045893 10.2 TNF IL6 IL4 IL1B IL10 CD4
5 negative regulation of apoptotic process GO:0043066 10.17 MYD88 IL6 IL4 IL2 IL10 CD40LG
6 adaptive immune response GO:0002250 10.15 IL2 IFNG ICOSLG CD8A CD4
7 inflammatory response GO:0006954 10.14 TNF TLR4 TLR2 MYD88 IL6 IL1B
8 positive regulation of gene expression GO:0010628 10.13 TNF TLR4 TLR2 MYD88 IL6 IL4
9 regulation of immune response GO:0050776 10.08 IL4 ICOSLG CD99 CD8A CD40LG
10 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.06 TNF TLR4 MYD88 IL1B CD4
11 positive regulation of protein phosphorylation GO:0001934 10.06 TNF IL2 IL1B IFNG CD4
12 response to lipopolysaccharide GO:0032496 10.04 TLR4 TLR2 MYD88 IL1B IL10
13 cellular response to lipopolysaccharide GO:0071222 10.04 TNF TLR4 MYD88 IL6 IL1B IL10
14 positive regulation of DNA-binding transcription factor activity GO:0051091 10.01 TNF IL6 IL1B IL10
15 cytokine-mediated signaling pathway GO:0019221 10.01 TNF MYD88 IL6 IL4 IL2 IL1B
16 defense response to Gram-positive bacterium GO:0050830 10 TNF TLR2 MYD88 IL6
17 positive regulation of JNK cascade GO:0046330 9.98 TNF TLR4 MYD88 IL1B
18 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.95 TNF IL6 IL4 IL2 IFNG
19 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.94 TNF TLR4 TLR2 IL1B
20 humoral immune response GO:0006959 9.94 TNF IL6 IFNG CCR6
21 regulation of insulin secretion GO:0050796 9.93 TNF IL1B IFNG
22 response to glucocorticoid GO:0051384 9.93 TNF IL6 IL10
23 positive regulation of inflammatory response GO:0050729 9.93 TNF TLR4 TLR2 IL2 IL1B IFNG
24 positive regulation of smooth muscle cell proliferation GO:0048661 9.92 TNF MYD88 IL6
25 positive regulation of tumor necrosis factor production GO:0032760 9.92 TLR4 TLR2 MYD88
26 T cell activation GO:0042110 9.92 IL4 ICOSLG CD8A CD4
27 positive regulation of interferon-gamma production GO:0032729 9.91 TNF TLR4 IL2 IL1B
28 positive regulation of nitric oxide biosynthetic process GO:0045429 9.91 TNF TLR4 IL1B IFNG
29 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 TNF TLR4 TLR2 MYD88 IL6 IL1B
30 positive regulation of phagocytosis GO:0050766 9.9 TNF IL1B IFNG
31 toll-like receptor signaling pathway GO:0002224 9.9 TLR4 TLR2 MYD88
32 positive regulation of B cell proliferation GO:0030890 9.9 TLR4 IL4 IL2
33 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.89 IL4 IL2 IL1B
34 negative regulation of interleukin-6 production GO:0032715 9.89 TNF TLR4 IL10
35 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.89 TLR4 TLR2 MYD88
36 positive regulation of cytokine secretion GO:0050715 9.89 TNF IL10 IFNG
37 microglial cell activation GO:0001774 9.89 TNF TLR2 IL4 IFNG
38 positive regulation of interleukin-6 secretion GO:2000778 9.89 TNF TLR4 TLR2 IL1B IFNG
39 positive regulation of JAK-STAT cascade GO:0046427 9.88 TNF IL6 IL10
40 positive regulation of interleukin-12 production GO:0032735 9.88 TLR4 TLR2 IFNG CD40LG
41 positive regulation of interleukin-10 production GO:0032733 9.88 TLR4 TLR2 IL4 CD40LG
42 negative regulation of neurogenesis GO:0050768 9.87 TNF IL6 IL1B
43 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.86 TNF TLR4 MYD88 IL6
44 positive regulation of glial cell proliferation GO:0060252 9.85 TNF IL6 IL1B
45 positive regulation of interleukin-8 secretion GO:2000484 9.85 TNF TLR4 TLR2
46 astrocyte activation GO:0048143 9.85 TNF IL1B IFNG
47 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.83 TNF IL1B IFNG
48 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.83 TNF IL1B IL10
49 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.83 TLR4 TLR2 IFNG
50 lipopolysaccharide-mediated signaling pathway GO:0031663 9.83 TNF TLR4 TLR2 MYD88 IL1B

Molecular functions related to Coccidiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.28 TNF TLR4 TLR2 MYD88 IL6 IL4
2 Toll-like receptor binding GO:0035325 9.26 TLR2 MYD88
3 growth factor activity GO:0008083 9.26 IL6 IL4 IL2 IL10
4 cytokine activity GO:0005125 9.23 TNF IL6 IL4 IL2 IL1B IL10
5 lipopolysaccharide receptor activity GO:0001875 9.16 TLR4 TLR2

Sources for Coccidiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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