MCID: CDN003
MIFTS: 12

Codeine Toxicity

Categories: Rare diseases

Aliases & Classifications for Codeine Toxicity

MalaCards integrated aliases for Codeine Toxicity:

Name: Codeine Toxicity 58

Classifications:



External Ids:

Orphanet 58 ORPHA240867

Summaries for Codeine Toxicity

MalaCards based summary : Codeine Toxicity is related to gastroparesis and diarrhea. An important gene associated with Codeine Toxicity is CYP2D6 (Cytochrome P450 Family 2 Subfamily D Member 6), and among its related pathways/superpathways are Glucose / Energy Metabolism and Statin Pathway - Generalized, Pharmacokinetics. Affiliated tissues include testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Codeine Toxicity

Diseases related to Codeine Toxicity via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 gastroparesis 9.6 CYP2D6 ABCB1
2 diarrhea 9.5 CYP2D6 ABCB1
3 major depressive disorder 9.5 CYP2D6 ABCB1
4 attention deficit-hyperactivity disorder 9.4 CYP2D6 ABCB1
5 malaria 9.2 CYP2D6 ABCB1

Graphical network of the top 20 diseases related to Codeine Toxicity:



Diseases related to Codeine Toxicity

Symptoms & Phenotypes for Codeine Toxicity

GenomeRNAi Phenotypes related to Codeine Toxicity according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.17 ABCB1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.17 ABCB1 CYP2D6
3 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.17 ABCB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-211 9.17 ABCB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-26 9.17 CYP2D6
6 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.17 CYP2D6

Drugs & Therapeutics for Codeine Toxicity

Search Clinical Trials , NIH Clinical Center for Codeine Toxicity

Genetic Tests for Codeine Toxicity

Anatomical Context for Codeine Toxicity

MalaCards organs/tissues related to Codeine Toxicity:

40
Testes

Publications for Codeine Toxicity

Articles related to Codeine Toxicity:

# Title Authors PMID Year
1
Pharmacogenetic testing in the Veterans Health Administration (VHA): policy recommendations from the VHA Clinical Pharmacogenetics Subcommittee. 61
29858578 2019
2
Fundamentals of Clinical Pharmacology With Application for Pregnant Women. 61
28498553 2017
3
Trends and characteristics of accidental and intentional codeine overdose deaths in Australia. 61
26424067 2015
4
Codeine-associated pediatric deaths despite using recommended dosing guidelines: three case reports. 61
23709324 2013
5
Editors' pick: codeine toxicity prediction in young infants - genotype the mothers. 61
23186321 2012
6
Prediction of codeine toxicity in infants and their mothers using a novel combination of maternal genetic markers. 61
22398969 2012

Variations for Codeine Toxicity

Expression for Codeine Toxicity

Search GEO for disease gene expression data for Codeine Toxicity.

Pathways for Codeine Toxicity

Pathways related to Codeine Toxicity according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.95 CYP2D6 ABCB1
2
Show member pathways
11.49 CYP2D6 ABCB1
3
Show member pathways
11.41 CYP2D6 ABCB1
4
Show member pathways
11.24 CYP2D6 ABCB1
5
Show member pathways
11.13 CYP2D6 ABCB1
6
Show member pathways
10.97 CYP2D6 ABCB1
7
Show member pathways
10.7 CYP2D6 ABCB1
8
Show member pathways
10.49 CYP2D6 ABCB1
9 9.8 CYP2D6 ABCB1

GO Terms for Codeine Toxicity

Sources for Codeine Toxicity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....