MCID: CNR001
MIFTS: 38

Coenurosis

Categories: Infectious diseases, Neuronal diseases, Skin diseases

Aliases & Classifications for Coenurosis

MalaCards integrated aliases for Coenurosis:

Name: Coenurosis 12 15
Coenuriasis 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050251
UMLS 74 C0009225

Summaries for Coenurosis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection by metacestode larval stage (coenurus) of Taenia multiceps or Taenia serialis. Coenuri in the skin or subcutaneous tissue present as painless nodules, which manifest on the trunk, sclera, subconjuctiva, neck, shoulders, head and limbs. Coenuri in the central nervous system may cause headache, fever, vomiting, nerve palsies, jacksonian epilepsy, pachymeningitis, obstructive or communicating hydrocephalus, and intracranial arteritis with transient hemiparesis. Coenuri in the eye cause both intraocular and orbital infections.

MalaCards based summary : Coenurosis, also known as coenuriasis, is related to cysticercosis and leber optic atrophy. An important gene associated with Coenurosis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways/superpathways are Sulfur amino acid metabolism and Ca, cAMP and Lipid Signaling. The drugs Immunologic Factors and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Coenurosis, also known as caenurosis, coenuriasis, gid or sturdy, is a parasitic infection that develops... more...

Related Diseases for Coenurosis

Diseases related to Coenurosis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 cysticercosis 30.4 MT-CO1 TACSTD2
2 leber optic atrophy 10.2 MT-CO1 MT-ND1
3 dressler's syndrome 10.2 LDHA LDHB
4 taeniasis 10.2 MT-CO1 MT-ND1 TACSTD2
5 sparganosis 10.1
6 cystic echinococcosis 10.1 MT-CO1 MT-ND1
7 papillary hidradenoma 9.9 ANXA11 ANXA2 ANXA6

Graphical network of the top 20 diseases related to Coenurosis:



Diseases related to Coenurosis

Symptoms & Phenotypes for Coenurosis

GenomeRNAi Phenotypes related to Coenurosis according to GeneCards Suite gene sharing:

27 (show all 28)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.34 GOT2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.34 ANXA3 ANXA4
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.34 ANXA7
4 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.34 ANXA7
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.34 ANXA3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.34 ANXA3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-133 10.34 ANXA3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.34 GOT2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.34 ANXA4
10 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.34 ANXA4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.34 GOT2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.34 ANXA7
13 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.34 ANXA3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.34 GOT2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-170 10.34 GOT2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.34 ANXA7
17 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.34 ANXA4
18 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.34 ANXA3
19 Increased shRNA abundance (Z-score > 2) GR00366-A-188 10.34 ANXA3 GOT2 ANXA7
20 Increased shRNA abundance (Z-score > 2) GR00366-A-201 10.34 ANXA3
21 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.34 ANXA4
22 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.34 GOT2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-65 10.34 ANXA4
24 Increased shRNA abundance (Z-score > 2) GR00366-A-76 10.34 ANXA4
25 Increased shRNA abundance (Z-score > 2) GR00366-A-8 10.34 ANXA3 ANXA4 GOT2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.34 ANXA7
27 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.34 ANXA7
28 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.1 ANXA1 ANXA13 ANXA2 ANXA4 ANXA6 ANXA7

Drugs & Therapeutics for Coenurosis

Drugs for Coenurosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 4,Phase 3,Phase 2,Not Applicable
2 Vaccines Phase 4,Phase 3,Phase 2,Not Applicable
3
Testosterone Approved, Experimental, Investigational Phase 3 58-22-0, 481-30-1 10204 6013
4
Testosterone undecanoate Approved, Investigational Phase 3 5949-44-0
5
Methyltestosterone Approved Phase 3 58-18-4 6010
6
Dutasteride Approved, Investigational Phase 3 164656-23-9 6918296 152945
7
Testosterone enanthate Approved Phase 3 315-37-7 9416
8
Polyestradiol phosphate Approved Phase 3 28014-46-2
9
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
10
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
11
Dihydrotestosterone Illicit, Investigational Phase 3 521-18-6 10635
12 5-alpha Reductase Inhibitors Phase 3
13 Antineoplastic Agents, Hormonal Phase 3
14 Testosterone 17 beta-cypionate Phase 3
15 Steroid Synthesis Inhibitors Phase 3
16 Hormone Antagonists Phase 3,Not Applicable
17 Estrogen Antagonists Phase 3
18 Anabolic Agents Phase 3
19 Aromatase Inhibitors Phase 3
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Not Applicable
21 Estrogens Phase 3
22 Hormones Phase 3,Not Applicable
23 Androgens Phase 3
24 Estradiol 3-benzoate Phase 3
25 Estradiol 17 beta-cypionate Phase 3
26 Estrogen Receptor Antagonists Phase 3
27
Zinc Approved, Investigational Not Applicable 7440-66-6 32051
28 glucocorticoids Not Applicable

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Study of Sanofi Pasteur's Intradermal Influenza Vaccine (IDflu™) in Adults and Elderly in Korea Completed NCT01215669 Phase 4
2 Testosterone and Its Metabolites in GID Completed NCT00146146 Phase 3 testosterone undecanoate alone;testosterone undecanoate plus letrozole;testosterone undecanoate plus dutasteride
3 Immunogenicity and Safety of a Vaccine Against Influenza (2010-2011 Northern Hemisphere Season, Intradermal Route) Completed NCT01138397 Phase 3
4 Lot-to-Lot Consistency Study of the Investigational, Inactivated, Split-Virion Influenza Vaccine in Adults Completed NCT00383539 Phase 3
5 Study of Inactivated, Split-Virion Influenza Vaccine Compared With the Reference Vaccine Vaxigrip® in the Elderly Completed NCT00383526 Phase 3
6 Study of the Influenza Vaccine (Split Virion, Inactivated) Northern Hemisphere 2009-2010 Formulation (Intradermal Route) Completed NCT00945438 Phase 2
7 Study of Immune Response in Adults and Elderly Subjects Vaccinated With Inactivated Influenza Vaccines Completed NCT00776438 Phase 2
8 Study of Inactivated, Split-Virion Influenza Vaccine Administered by Intradermal Route Versus Vaxigrip® in Adults Completed NCT00703651 Phase 2
9 Immunogenicity of the Inactivated Split-Virion Influenza Vaccine in Renal Transplant Subjects Completed NCT00606359 Phase 2
10 Immunogenicity of Two Dosages of Inactivated, Split-Virion Influenza Vaccine Given by an Alternate Route in the Elderly Completed NCT00296829 Phase 2
11 Immunogenicity Study of the Influenza Vaccine in Adults Completed NCT00258934 Phase 2
12 Study to Assess the Efficacy and Safety of SK-MS10 in Subjects With Acute and Chronic Gastritis Completed NCT01578811 Phase 2 Placebo;SK-MS10;SK-MS10
13 Intervention to Increase Screening for Glucocorticoid Induced Diabetes Completed NCT01743963 Not Applicable
14 Leuven Growing Into Deficit Follow-up Study Completed NCT01632813
15 Adipose-derived SVF for Treatment of Alopecia Completed NCT02626780 Not Applicable
16 Diarrhea and Bivalent Oral Polio Vaccine Immunity Completed NCT01559636 Not Applicable
17 Impact of Improving GI Symptoms on Autism Symptoms and Oxidative Stress Recruiting NCT02442115
18 Adipose-derived SVF for the Treatment of Knee OA Active, not recruiting NCT02726945 Not Applicable
19 Adipose-derived SVF for Treatment of Erectile Dysfunction (ED) Not yet recruiting NCT03886402 Not Applicable

Search NIH Clinical Center for Coenurosis

Genetic Tests for Coenurosis

Anatomical Context for Coenurosis

MalaCards organs/tissues related to Coenurosis:

42
Skin, Eye, Brain

Publications for Coenurosis

Articles related to Coenurosis:

(show top 50) (show all 89)
# Title Authors Year
1
Taenia multiceps coenurosis in Tanzania: a major and under-recognised livestock disease problem in pastoral communities. ( 30683735 )
2019
2
Comparative molecular characterization and phylogenetic analysis of cerebral and non-cerebral coenurosis in Indian goats. ( 30929943 )
2019
3
Cerebral Coenurosis Masquerading as Malignancy: A Rare Case Report from India. ( 31001039 )
2019
4
Severe coenurosis caused by larvae of Taenia serialis in an olive baboon (Papio anubis) in Benin. ( 31080729 )
2019
5
Atypical outbreak of acute coenurosis by Taenia multiceps in a sheep flock. ( 29671047 )
2018
6
A Case of Coenurosis in a Wild Rabbit (Lepus sinensis) Caused by Taenia serialis Metacestode in Qinghai Tibetan Plateau Area, China. ( 29742875 )
2018
7
The genome of tapeworm Taenia multiceps sheds light on understanding parasitic mechanism and control of coenurosis disease. ( 29947776 )
2018
8
Clinical, pathological and molecular evaluations and CT scan screening of coenurosis (Coenurus cerebralis) in sheep and calves. ( 28177040 )
2017
9
Neuropathological lesions of clinical and sub clinical Coenurosis (Coenurus cerebralis) in organized goat farms in India. ( 28426417 )
2017
10
Diagnosis and surgical management of non-cerebral coenurosis (Taenia gaigeri) in local Black Bengal goat of Tripura: report of six cases. ( 27605809 )
2016
11
Cerebral and non-cerebral coenurosis: on the genotypic and phenotypic diversity of Taenia multiceps. ( 27630103 )
2016
12
Clinical evolution of cerebral coenurosis from invasive to chronic infection in sheep and a goat. ( 27801381 )
2016
13
Clinical and morphopathological characteristics of an enzootic occurrence of acute coenurosis (Coenurus cerebralis) in a sheep herd. ( 26064018 )
2015
14
Characteristics of non-cerebral coenurosis in tropical goats. ( 26073108 )
2015
15
Experimental cerebral and non-cerebral coenurosis in goats: A comparative study on the morphological and molecular characteristics of the parasite. ( 26116455 )
2015
16
Application of polymerase chain reaction on cerebrospinal fluid for diagnosis of cerebral coenurosis in small ruminants. ( 26122997 )
2015
17
Regurgitations in a Lamb with Acute Coenurosis-A case Report. ( 26246831 )
2015
18
Prevalence of coenurosis in sheep and goats at three slaughter slabs in Ngorongoro District, Tanzania. ( 26306799 )
2015
19
Pathology in Practice. Cerebellar coenurosis in a sheep. ( 26421400 )
2015
20
Comparison of cerebral and non-cerebral coenurosis by genetic markers of glycolytic enzyme (enolase) and mitochondrial sequences in sheep and goats. ( 26527237 )
2015
21
Cisternal cerebrospinal fluid analysis in 24 sheep with chronic coenurosis. ( 24715594 )
2014
22
Cerebral and non-cerebral coenurosis in small ruminants. ( 24862039 )
2014
23
Early stage of acute coenurosis in Iranian native sheep- case report. ( 25759742 )
2014
24
MRS findings in cerebral coenurosis due to Taenia multiceps. ( 21699611 )
2013
25
Occurrence of non-cerebral coenurosis in sheep. ( 22260813 )
2013
26
Morphological and molecular characterization of bovine coenurosis in Sardinia, Italy. ( 23274489 )
2013
27
Other cestodes: sparganosis, coenurosis and Taenia crassiceps cysticercosis. ( 23829923 )
2013
28
Molecular identification of Taenia serialis coenurosis in a wild Ethiopian gelada (Theropithecus gelada). ( 24050944 )
2013
29
AIRP best cases in radiologic-pathologic correlation: human coenurosis (Taenia Larva). ( 22411946 )
2012
30
Diagnosis and treatment of coenurosis in sheep. ( 22503036 )
2012
31
Acute coenurosis of dairy sheep from 11 flocks in Greece. ( 22506508 )
2012
32
Molecular characterization of subcutaneous and muscular coenurosis of goats in United Arab Emirates. ( 22884911 )
2012
33
Cerebral coenurosis in a cat caused by Taenia serialis: neurological, magnetic resonance imaging and pathological features. ( 22918847 )
2012
34
Magnetic resonance imaging of the brain and skull of sheep with cerebral coenurosis. ( 23176417 )
2012
35
Prevalence and molecular characterization of bovine coenurosis from Eastern Anatolian region of Turkey. ( 21074326 )
2011
36
Cerebral coenurosis mimicking hydatid disease - report of two cases from South India. ( 21176715 )
2011
37
Survey on coenurosis in sheep and goats in Egypt. ( 21947971 )
2011
38
Non-cerebral coenurosis in goats. ( 20502917 )
2010
39
First report of coenurosis in sheep in the State of Mato Grosso do Sul, Brazil. ( 21184708 )
2010
40
Preliminary field trial of a vaccine against coenurosis caused by Taenia multiceps. ( 19345506 )
2009
41
Cerebellar dysfunction in a calf with chronic coenurosis. ( 19377093 )
2009
42
A survey of Taenia multiceps coenurosis in Sardinian sheep. ( 16973285 )
2007
43
Two rare clinical manifestations of coenurosis in sheep. ( 17027156 )
2007
44
Coenurosis in a beef cattle herd in Greece. ( 18024927 )
2007
45
Contribution of NADH dehydrogenase subunit I and cytochrome C oxidase subunit I sequences toward identifying a case of human coenuriasis in France. ( 17918379 )
2007
46
Spinal coenurosis causing posterior paralysis in a goat in Mongolia. ( 16489162 )
2006
47
Updates on morphobiology, epidemiology and molecular characterization of coenurosis in sheep. ( 16881398 )
2006
48
Cerebral coenurosis. Case illustration. ( 15137619 )
2004
49
Coenurosis in a pet rabbit. ( 11258733 )
2001
50
Correlation between MRI, computed tomographic findings and clinical signs in a case of ovine coenurosis. ( 10777046 )
2000

Variations for Coenurosis

Expression for Coenurosis

Search GEO for disease gene expression data for Coenurosis.

Pathways for Coenurosis

GO Terms for Coenurosis

Cellular components related to Coenurosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.8 ANXA1 ANXA2 ANXA4 ANXA9 GOT2
2 late endosome membrane GO:0031902 9.61 ANXA2 ANXA6 ANXA8
3 sarcolemma GO:0042383 9.5 ANXA1 ANXA2 GOT2
4 melanosome GO:0042470 9.43 ANXA11 ANXA2 ANXA6
5 collagen-containing extracellular matrix GO:0062023 9.43 ANXA1 ANXA11 ANXA2 ANXA4 ANXA6 ANXA8
6 extracellular exosome GO:0070062 9.4 ANXA1 ANXA11 ANXA13 ANXA2 ANXA3 ANXA4
7 specific granule GO:0042581 9.16 ANXA11 ANXA3
8 cytosol GO:0005829 10.15 ANXA1 ANXA11 ANXA2 ANXA3 ANXA4 ANXA7

Biological processes related to Coenurosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell adhesion GO:0098609 9.56 ANXA1 ANXA2 ANXA9 TACSTD2
2 phagocytosis GO:0006909 9.54 ANXA1 ANXA11 ANXA3
3 pyruvate metabolic process GO:0006090 9.48 LDHA LDHB
4 carboxylic acid metabolic process GO:0019752 9.46 LDHA LDHB
5 negative regulation of serine-type endopeptidase activity GO:1900004 9.43 ANXA8 ANXA8L1
6 positive regulation of vesicle fusion GO:0031340 9.4 ANXA1 ANXA2
7 response to organic cyclic compound GO:0014070 9.33 ANXA1 ANXA7 MT-ND1
8 negative regulation of interleukin-8 secretion GO:2000483 9.32 ANXA1 ANXA4
9 negative regulation of catalytic activity GO:0043086 9.26 ANXA1 ANXA2 ANXA3 ANXA4
10 negative regulation of phospholipase A2 activity GO:1900138 8.8 ANXA1 ANXA8 ANXA8L1

Molecular functions related to Coenurosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.73 ANXA1 ANXA10 ANXA11 ANXA13 ANXA2 ANXA3
2 calcium-dependent protein binding GO:0048306 9.7 ANXA1 ANXA11 ANXA2 ANXA3 ANXA4 ANXA6
3 phospholipid binding GO:0005543 9.69 ANXA1 ANXA9 GOT2
4 phosphatidylserine binding GO:0001786 9.67 ANXA13 ANXA2 ANXA6 ANXA9
5 phosphatidylinositol-4,5-bisphosphate binding GO:0005546 9.65 ANXA2 ANXA8 ANXA8L1
6 cadherin binding involved in cell-cell adhesion GO:0098641 9.58 ANXA1 ANXA2 TACSTD2
7 phosphatidylinositol-3,4-bisphosphate binding GO:0043325 9.52 ANXA8 ANXA8L1
8 phospholipase inhibitor activity GO:0004859 9.5 ANXA1 ANXA2 ANXA4
9 S100 protein binding GO:0044548 9.49 ANXA11 ANXA2
10 chondroitin sulfate binding GO:0035374 9.46 ANXA4 ANXA6
11 L-lactate dehydrogenase activity GO:0004459 9.43 LDHA LDHB
12 phospholipase A2 inhibitor activity GO:0019834 9.43 ANXA1 ANXA2 ANXA3
13 calcium-dependent phospholipid binding GO:0005544 9.4 ANXA1 ANXA10 ANXA11 ANXA13 ANXA2 ANXA3

Sources for Coenurosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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