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MCID: CGN001
MIFTS: 24

Cogan-Reese Syndrome

Categories: Eye diseases, Fetal diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications
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Aliases & Classifications for Cogan-Reese Syndrome

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MalaCards integrated aliases for Cogan-Reese Syndrome:

Name: Cogan-Reese Syndrome 12 74 52 58 15 71

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases
Anatomical: Eye diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare eye diseases
Developmental anomalies during embryogenesis


External Ids:

Disease Ontology 12 DOID:0060217
NCIt 49 C84644
SNOMED-CT 67 404633004
ICD10 via Orphanet 33 H21.2
UMLS via Orphanet 72 C1168173
Orphanet 58 ORPHA98980
UMLS 71 C1168173
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Summaries for Cogan-Reese Syndrome

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NIH Rare Diseases : 52 Cogan-Reese syndrome is one type of Iridocorneal Endothelial (ICE) syndrome . The ICE syndromes predominantly affect Caucasian, young to middle-aged women, and involve one eye. While there have been some cases of Cogan-Reese syndrome reported in children, the disease is typically observed in females in the mid-adult years. In one study of 71 patients with ICE syndrome, the mean age at diagnosis was 51-years. Known glaucoma was present in 11 (15%) of cases. While it is not yet known how to keep Cogan-Reese syndrome from progressing, the glaucoma associated with the disease can be treated with medication. Additionally, corneal transplant can treat any corneal swelling. The National Eye Institute provides information on screening for glaucoma HERE .

MalaCards based summary : Cogan-Reese Syndrome is related to corneal endothelial dystrophy and corneal edema. An important gene associated with Cogan-Reese Syndrome is PDLIM2 (PDZ And LIM Domain 2). Affiliated tissues include iris, endothelial and eye.

Disease Ontology : 12 An eye disease characterized by variable iris atrophy, pigmented and pedunculated nodules located in iris and attachment of the iris to the cornea (peripheral anterior synechiae) and characterized by glaucoma.

Wikipedia : 74 Iridocorneal Endothelial (ICE) syndromes are a spectrum of diseases characterized by slowly progressive... more...

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Related Diseases for Cogan-Reese Syndrome

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Diseases related to Cogan-Reese Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 corneal endothelial dystrophy 31.9 OVOL2 COL8A2
2 corneal edema 30.1 OVOL2 COL8A2
3 iridocorneal endothelial syndrome 12.0
4 essential iris atrophy 10.8
5 ectropion 10.6
6 intraocular pressure quantitative trait locus 10.6
7 3-methylglutaconic aciduria, type iii 10.5
8 open-angle glaucoma 10.5
9 aniridia 1 10.3
10 exfoliation syndrome 10.3
11 lung cancer susceptibility 3 10.3
12 keratoconus 10.3
13 juvenile glaucoma 10.3
14 corneal degeneration 10.3
15 iritis 10.3
16 keratopathy 10.3
17 adenocarcinoma 10.3
18 corneal ulcer 10.3
19 endotheliitis 10.3
20 overgrowth syndrome 10.3
21 secondary corneal edema 9.9 PDLIM2 COL8A2
22 corneal dystrophy, posterior polymorphous, 2 9.5 OVOL2 COL8A2
23 corneal dystrophy 9.4 OVOL2 COL8A2
24 corneal dystrophy, posterior polymorphous, 3 9.4 OVOL2 COL8A2
25 corneal dystrophy, posterior polymorphous, 1 9.2 OVOL2 COL8A2

Graphical network of the top 20 diseases related to Cogan-Reese Syndrome:



Diseases related to Cogan-Reese Syndrome
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Symptoms & Phenotypes for Cogan-Reese Syndrome

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Drugs & Therapeutics for Cogan-Reese Syndrome

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Search Clinical Trials , NIH Clinical Center for Cogan-Reese Syndrome

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Genetic Tests for Cogan-Reese Syndrome

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Anatomical Context for Cogan-Reese Syndrome

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The Foundational Model of Anatomy Ontology organs/tissues related to Cogan-Reese Syndrome:

19
Iris

MalaCards organs/tissues related to Cogan-Reese Syndrome:

40
Endothelial, Eye, Lung
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Publications for Cogan-Reese Syndrome

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Articles related to Cogan-Reese Syndrome:

(show all 49)
# Title Authors PMID Year
1
Cogan-Reese syndrome with Iris cyst: A novel presentation. 61
31104851 2019
2
Cogan-Reese syndrome: image analysis with specular microscopy, optical coherence tomography, and ultrasound biomicroscopy. 61
31327934 2019
3
Unique variations and characteristics of iridocorneal endothelial syndrome in China: a case series of 58 patients. 61
28993974 2018
4
The iridocorneal endothelial syndrome. 61
29331589 2018
5
Glaucoma associated with iridocorneal endothelial syndrome in 203 Indian subjects. 61
28282413 2017
6
A unique case of keratoconus with Cogan-Reese syndrome and secondary glaucoma. 61
28300746 2017
7
Cystoid macular edema associated with iridocorneal endothelial syndrome: a case report. 61
27585567 2016
8
ICE SYNDROME--CASE REPORT. 61
26978875 2015
9
Diagnosis and Management of Iridocorneal Endothelial Syndrome. 61
26451377 2015
10
Optical coherence tomography characteristics of the iris in Cogan-Reese syndrome. 61
24729138 2014
11
Metastatic lung adenocarcinoma to the iris mimicking Cogan-Reese syndrome. 61
21897284 2012
12
Association of Cogan-Reese syndrome, exfoliation syndrome, and secondary open-angle glaucoma. 61
22167551 2012
13
[Glaucoma with primary iris malformations. Axenfeld-Rieger syndromes, ICE syndromes (essential iris atrophy, Chandler's syndrome, Cogan-Reese syndrome), aniridia]. 61
21695610 2011
14
Iris mammillations in two female siblings with congenital adrenal hyperplasia. 61
22802477 2010
15
Iris naevus (Cogan-Reese) syndrome. 61
18975517 2008
16
[Iridocorneal endothelial syndrome and glaucoma]. 61
17318107 2007
17
Iris melanocytoma mimicking the Cogan-Reese syndrome with monocular pigment dissemination. 61
17191198 2006
18
Ultrasound biomicroscopy of Chinese eyes with iridocorneal endothelial syndrome. 61
16361670 2006
19
[Iridocorneal endothelial syndrome (ICE-S): classification, clinical picture, diagnosis]. 61
16240272 2005
20
[Iridocorneal endothelial syndrome. Series of 7 cases]. 61
11460060 2001
21
Clinical and specular microscopic manifestations of iridocorneal endothelial syndrome. 61
11369379 2001
22
Iridocorneal endothelial syndrome in Thai patients: clinical variations. 61
10676783 2000
23
Clinical and histopathologic findings of iris nevus (Cogan-Reese) syndrome. 61
10321548 1999
24
Cogan-Reese syndrome. Progressive growth of endothelium over iris. 61
9715703 1998
25
[A case of Cogan-Reese syndrome (iris nevus syndrome)]. 61
9577120 1997
26
Bilateral iridocorneal endothelial syndrome presented as Cogan-Reese and Chandler's syndrome. 61
8795735 1996
27
[Posner-Schlossman syndrome]. 61
1475095 1992
28
[Clinical aspects and histopathology of the Cogan-Reese syndrome]. 61
2243475 1990
29
[Iris nevus (Cogan-Reese) syndrome--clinicopathological correlations]. 61
2360491 1990
30
A comparison of the clinical variations of the iridocorneal endothelial syndrome. 61
2803093 1989
31
Iris nevus syndrome. 61
3190109 1988
32
Surgical results in iridocorneal endothelial syndrome. 61
3341974 1988
33
[A new iridocorneal endothelial syndrome]. 61
3626410 1987
34
Pathogenesis of Chandler's syndrome, essential iris atrophy and the Cogan-Reese syndrome. I. Alterations of the corneal endothelium. 61
3710728 1986
35
Pathogenesis of Chandler's syndrome, essential iris atrophy and the Cogan-Reese syndrome. II. Estimated age at disease onset. 61
3710729 1986
36
[Specular microscopy in the diagnosis of the iridocorneal endothelial syndrome]. 61
3879610 1985
37
[Cogan-Reese syndrome: therapeutic difficulties (apropos of 2 cases)]. 61
6545164 1984
38
[Iris angiography and endothelium microscopy in dysgenesis mesodermalis iridis et corneae]. 61
6632679 1983
39
[Cogan-Reese syndrome]. 61
7132178 1982
40
The iris naevus (Cogan-Reese) syndrome: light and electron microscopic observations. 61
7387971 1980
41
Histopathology in the iris-nevus (Cogan-Reese) syndrome. 61
6992584 1980
42
[Cogan-Reese syndrome]. 61
6447901 1980
43
[Histological findings in dysgenesis mesodermalis iridis et corneae Rieger]. 61
6903107 1980
44
Proliferative endotheliopathy with iris abnormalities. The iridocorneal endothelial syndrome. 61
508177 1979
45
Progressive essential iris atrophy, Chandler's syndrome, and the iris nevus (Cogan-Reese) syndrome: a spectrum of disease. 61
483159 1979
46
Iris nevus syndrome. 61
743612 1978
47
Histopathology of cornea and iris in Chandler's syndrome. 61
308798 1978
48
The corneal endothelium and the spectrum of essential iris atrophy. 61
717494 1978
49
Iris nevus (Cogan-Reese) syndrome. A cause of unilateral glaucoma. 61
1180755 1975
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Variations for Cogan-Reese Syndrome

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Expression for Cogan-Reese Syndrome

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Search GEO for disease gene expression data for Cogan-Reese Syndrome.
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Pathways for Cogan-Reese Syndrome

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GO Terms for Cogan-Reese Syndrome

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Biological processes related to Cogan-Reese Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of epithelial to mesenchymal transition GO:0010719 8.62 OVOL2 LDLRAD4
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Sources for Cogan-Reese Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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