MCID: CGN001
MIFTS: 24

Cogan-Reese Syndrome

Categories: Eye diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Cogan-Reese Syndrome

MalaCards integrated aliases for Cogan-Reese Syndrome:

Name: Cogan-Reese Syndrome 12 53 59 15 73
Coganreese Syndrome 76

Classifications:



External Ids:

Disease Ontology 12 DOID:0060217
NCIt 50 C84644
Orphanet 59 ORPHA98980
ICD10 via Orphanet 34 H21.2
UMLS via Orphanet 74 C1168173
UMLS 73 C1168173

Summaries for Cogan-Reese Syndrome

NIH Rare Diseases : 53 Cogan-Reese syndrome is one type of Iridocorneal Endothelial (ICE) syndrome. The ICE syndromes predominantly affect Caucasian, young to middle-aged women, and involve one eye. While there have been some cases of Cogan-Reese syndrome reported in children, the disease is typically observed in females in the mid-adult years. In one study of 71 patients with ICE syndrome, the mean age at diagnosis was 51-years. Known glaucoma was present in 11 (15%) of cases. While it is not yet known how to keep Cogan-Reese syndrome from progressing, the glaucoma associated with the disease can be treated with medication. Additionally, corneal transplant can treat any corneal swelling. The National Eye Institute provides information on screening for glaucoma HERE. 

MalaCards based summary : Cogan-Reese Syndrome, also known as coganreese syndrome, is related to corneal endothelial dystrophy and iridocorneal endothelial syndrome. An important gene associated with Cogan-Reese Syndrome is CAMLG (Calcium Modulating Ligand). Affiliated tissues include eye, endothelial and lung, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 An eye disease characterized by variable iris atrophy, pigmented and pedunculated nodules located in iris and attachment of the iris to the cornea (peripheral anterior synechiae) and characterized_by glaucoma.

Wikipedia : 76 Iridocorneal Endothelial (ICE) syndromes are a spectrum of diseases characteriezed by slowly progressive... more...

Related Diseases for Cogan-Reese Syndrome

Diseases related to Cogan-Reese Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 corneal endothelial dystrophy 11.4
2 iridocorneal endothelial syndrome 11.4
3 essential iris atrophy 10.5
4 exfoliation syndrome 10.3
5 lung cancer susceptibility 3 10.3
6 keratoconus 10.3
7 open-angle glaucoma 10.3
8 adenocarcinoma 10.3

Graphical network of the top 20 diseases related to Cogan-Reese Syndrome:



Diseases related to Cogan-Reese Syndrome

Symptoms & Phenotypes for Cogan-Reese Syndrome

MGI Mouse Phenotypes related to Cogan-Reese Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.13 CAMLG PDLIM2 PITX2
2 immune system MP:0005387 8.8 CAMLG PDLIM2 PITX2

Drugs & Therapeutics for Cogan-Reese Syndrome

Search Clinical Trials , NIH Clinical Center for Cogan-Reese Syndrome

Genetic Tests for Cogan-Reese Syndrome

Anatomical Context for Cogan-Reese Syndrome

MalaCards organs/tissues related to Cogan-Reese Syndrome:

41
Eye, Endothelial, Lung

The Foundational Model of Anatomy Ontology organs/tissues related to Cogan-Reese Syndrome:

19
Iris

Publications for Cogan-Reese Syndrome

Articles related to Cogan-Reese Syndrome:

(show all 14)
# Title Authors Year
1
A unique case of keratoconus with Cogan-Reese syndrome and secondary glaucoma. ( 28300746 )
2017
2
Optical coherence tomography characteristics of the iris in Cogan-Reese syndrome. ( 24729138 )
2014
3
Association of Cogan-Reese syndrome, exfoliation syndrome, and secondary open-angle glaucoma. ( 22167551 )
2012
4
Metastatic lung adenocarcinoma to the iris mimicking Cogan-Reese syndrome. ( 21897284 )
2012
5
Iris naevus (Cogan-Reese) syndrome. ( 18975517 )
2008
6
Iris melanocytoma mimicking the Cogan-Reese syndrome with monocular pigment dissemination. ( 17191198 )
2006
7
Clinical and histopathologic findings of iris nevus (Cogan-Reese) syndrome. ( 10321548 )
1999
8
Cogan-Reese syndrome. Progressive growth of endothelium over iris. ( 9715703 )
1998
9
Pathogenesis of Chandler's syndrome, essential iris atrophy and the Cogan-Reese syndrome. I. Alterations of the corneal endothelium. ( 3710728 )
1986
10
Pathogenesis of Chandler's syndrome, essential iris atrophy and the Cogan-Reese syndrome. II. Estimated age at disease onset. ( 3710729 )
1986
11
Histopathology in the iris-nevus (Cogan-Reese) syndrome. ( 6992584 )
1980
12
The iris naevus (Cogan-Reese) syndrome: light and electron microscopic observations. ( 7387971 )
1980
13
Progressive essential iris atrophy, Chandler's syndrome, and the iris nevus (Cogan-Reese) syndrome: a spectrum of disease. ( 483159 )
1979
14
Iris nevus (Cogan-Reese) syndrome. A cause of unilateral glaucoma. ( 1180755 )
1975

Variations for Cogan-Reese Syndrome

Expression for Cogan-Reese Syndrome

Search GEO for disease gene expression data for Cogan-Reese Syndrome.

Pathways for Cogan-Reese Syndrome

GO Terms for Cogan-Reese Syndrome

Sources for Cogan-Reese Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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