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MCID: CGN001
MIFTS: 24

Cogan-Reese Syndrome

Categories: Eye diseases, Fetal diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications
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Aliases & Classifications for Cogan-Reese Syndrome

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MalaCards integrated aliases for Cogan-Reese Syndrome:

Name: Cogan-Reese Syndrome 12 74 20 58 15 71

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases
Anatomical: Eye diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare eye diseases
Developmental anomalies during embryogenesis


External Ids:

Disease Ontology 12 DOID:0060217
NCIt 50 C84644
SNOMED-CT 67 129624009
ICD10 via Orphanet 33 H21.2
UMLS via Orphanet 72 C1168173
Orphanet 58 ORPHA98980
UMLS 71 C1168173
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Summaries for Cogan-Reese Syndrome

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GARD : 20 Cogan-Reese syndrome is one type of Iridocorneal Endothelial (ICE) syndrome. The ICE syndromes predominantly affect Caucasian, young to middle-aged women, and involve one eye. While there have been some cases of Cogan-Reese syndrome reported in children, the disease is typically observed in females in the mid-adult years. In one study of 71 patients with ICE syndrome, the mean age at diagnosis was 51-years. Known glaucoma was present in 11 (15%) of cases. While it is not yet known how to keep Cogan-Reese syndrome from progressing, the glaucoma associated with the disease can be treated with medication. Additionally, corneal transplant can treat any corneal swelling. The National Eye Institute provides information on screening for glaucoma HERE.

MalaCards based summary : Cogan-Reese Syndrome is related to corneal endothelial dystrophy and corneal edema. An important gene associated with Cogan-Reese Syndrome is MYNN (Myoneurin). Affiliated tissues include iris, eye and endothelial.

Disease Ontology : 12 An eye disease characterized by variable iris atrophy, pigmented and pedunculated nodules located in iris and attachment of the iris to the cornea (peripheral anterior synechiae) and characterized by glaucoma.

Wikipedia : 74 Iridocorneal Endothelial (ICE) syndromes are a spectrum of diseases characterized by slowly progressive... more...

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Related Diseases for Cogan-Reese Syndrome

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Diseases related to Cogan-Reese Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)
# Related Disease Score Top Affiliating Genes
1 corneal endothelial dystrophy 31.1 SLC4A11 OVOL2
2 corneal edema 30.0 SLC4A11 OVOL2
3 iridocorneal endothelial syndrome 11.3
4 essential iris atrophy 10.6
5 intraocular pressure quantitative trait locus 10.4
6 ectropion 10.4
7 3-methylglutaconic aciduria, type iii 10.3
8 open-angle glaucoma 10.3
9 aniridia 1 10.1
10 exfoliation syndrome 10.1
11 lung cancer susceptibility 3 10.1
12 keratoconus 10.1
13 juvenile glaucoma 10.1
14 corneal degeneration 10.1
15 iritis 10.1
16 keratopathy 10.1
17 adenocarcinoma 10.1
18 corneal ulcer 10.1
19 endotheliitis 10.1
20 overgrowth syndrome 10.1
21 corneal dystrophy, posterior polymorphous, 2 9.7 SLC4A11 OVOL2
22 corneal dystrophy 9.7 SLC4A11 OVOL2
23 corneal dystrophy, posterior polymorphous, 3 9.7 SLC4A11 OVOL2
24 corneal dystrophy, posterior polymorphous, 1 9.6 SLC4A11 OVOL2

Graphical network of the top 20 diseases related to Cogan-Reese Syndrome:



Diseases related to Cogan-Reese Syndrome
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Symptoms & Phenotypes for Cogan-Reese Syndrome

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Drugs & Therapeutics for Cogan-Reese Syndrome

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Search Clinical Trials , NIH Clinical Center for Cogan-Reese Syndrome

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Genetic Tests for Cogan-Reese Syndrome

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Anatomical Context for Cogan-Reese Syndrome

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The Foundational Model of Anatomy Ontology organs/tissues related to Cogan-Reese Syndrome:

19
Iris

MalaCards organs/tissues related to Cogan-Reese Syndrome:

40
Eye, Endothelial
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Publications for Cogan-Reese Syndrome

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Articles related to Cogan-Reese Syndrome:

(show top 50) (show all 51)
# Title Authors PMID Year
1
Cogan Reese Syndrome, a Unilateral Puzzling Cause of Secondary Glaucoma. 61
33008560 2020
2
Our experience with micropulse cyclophotocoagulation in the therapy of glaucoma. 61
32917092 2020
3
Cogan-Reese syndrome with Iris cyst: A novel presentation. 61
31104851 2019
4
Cogan-Reese syndrome: image analysis with specular microscopy, optical coherence tomography, and ultrasound biomicroscopy. 61
31327934 2019
5
Unique variations and characteristics of iridocorneal endothelial syndrome in China: a case series of 58 patients. 61
28993974 2018
6
The iridocorneal endothelial syndrome. 61
29331589 2018
7
Glaucoma associated with iridocorneal endothelial syndrome in 203 Indian subjects. 61
28282413 2017
8
A unique case of keratoconus with Cogan-Reese syndrome and secondary glaucoma. 61
28300746 2017
9
Cystoid macular edema associated with iridocorneal endothelial syndrome: a case report. 61
27585567 2016
10
ICE SYNDROME--CASE REPORT. 61
26978875 2015
11
Diagnosis and Management of Iridocorneal Endothelial Syndrome. 61
26451377 2015
12
Optical coherence tomography characteristics of the iris in Cogan-Reese syndrome. 61
24729138 2014
13
Metastatic lung adenocarcinoma to the iris mimicking Cogan-Reese syndrome. 61
21897284 2012
14
Association of Cogan-Reese syndrome, exfoliation syndrome, and secondary open-angle glaucoma. 61
22167551 2012
15
[Glaucoma with primary iris malformations. Axenfeld-Rieger syndromes, ICE syndromes (essential iris atrophy, Chandler's syndrome, Cogan-Reese syndrome), aniridia]. 61
21695610 2011
16
Iris mammillations in two female siblings with congenital adrenal hyperplasia. 61
22802477 2010
17
Iris naevus (Cogan-Reese) syndrome. 61
18975517 2008
18
[Iridocorneal endothelial syndrome and glaucoma]. 61
17318107 2007
19
Iris melanocytoma mimicking the Cogan-Reese syndrome with monocular pigment dissemination. 61
17191198 2006
20
Ultrasound biomicroscopy of Chinese eyes with iridocorneal endothelial syndrome. 61
16361670 2006
21
[Iridocorneal endothelial syndrome (ICE-S): classification, clinical picture, diagnosis]. 61
16240272 2005
22
[Iridocorneal endothelial syndrome. Series of 7 cases]. 61
11460060 2001
23
Clinical and specular microscopic manifestations of iridocorneal endothelial syndrome. 61
11369379 2001
24
Iridocorneal endothelial syndrome in Thai patients: clinical variations. 61
10676783 2000
25
Clinical and histopathologic findings of iris nevus (Cogan-Reese) syndrome. 61
10321548 1999
26
Cogan-Reese syndrome. Progressive growth of endothelium over iris. 61
9715703 1998
27
[A case of Cogan-Reese syndrome (iris nevus syndrome)]. 61
9577120 1997
28
Bilateral iridocorneal endothelial syndrome presented as Cogan-Reese and Chandler's syndrome. 61
8795735 1996
29
[Posner-Schlossman syndrome]. 61
1475095 1992
30
[Clinical aspects and histopathology of the Cogan-Reese syndrome]. 61
2243475 1990
31
[Iris nevus (Cogan-Reese) syndrome--clinicopathological correlations]. 61
2360491 1990
32
A comparison of the clinical variations of the iridocorneal endothelial syndrome. 61
2803093 1989
33
Iris nevus syndrome. 61
3190109 1988
34
Surgical results in iridocorneal endothelial syndrome. 61
3341974 1988
35
[A new iridocorneal endothelial syndrome]. 61
3626410 1987
36
Pathogenesis of Chandler's syndrome, essential iris atrophy and the Cogan-Reese syndrome. II. Estimated age at disease onset. 61
3710729 1986
37
Pathogenesis of Chandler's syndrome, essential iris atrophy and the Cogan-Reese syndrome. I. Alterations of the corneal endothelium. 61
3710728 1986
38
[Specular microscopy in the diagnosis of the iridocorneal endothelial syndrome]. 61
3879610 1985
39
[Cogan-Reese syndrome: therapeutic difficulties (apropos of 2 cases)]. 61
6545164 1984
40
[Iris angiography and endothelium microscopy in dysgenesis mesodermalis iridis et corneae]. 61
6632679 1983
41
[Cogan-Reese syndrome]. 61
7132178 1982
42
Histopathology in the iris-nevus (Cogan-Reese) syndrome. 61
6992584 1980
43
The iris naevus (Cogan-Reese) syndrome: light and electron microscopic observations. 61
7387971 1980
44
[Histological findings in dysgenesis mesodermalis iridis et corneae Rieger]. 61
6903107 1980
45
[Cogan-Reese syndrome]. 61
6447901 1980
46
Proliferative endotheliopathy with iris abnormalities. The iridocorneal endothelial syndrome. 61
508177 1979
47
Progressive essential iris atrophy, Chandler's syndrome, and the iris nevus (Cogan-Reese) syndrome: a spectrum of disease. 61
483159 1979
48
Iris nevus syndrome. 61
743612 1978
49
Histopathology of cornea and iris in Chandler's syndrome. 61
308798 1978
50
The corneal endothelium and the spectrum of essential iris atrophy. 61
717494 1978
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Variations for Cogan-Reese Syndrome

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Expression for Cogan-Reese Syndrome

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Search GEO for disease gene expression data for Cogan-Reese Syndrome.
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Pathways for Cogan-Reese Syndrome

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GO Terms for Cogan-Reese Syndrome

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Biological processes related to Cogan-Reese Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 8.92 ZBTB24 TSC22D1 OVOL2 MYNN
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Sources for Cogan-Reese Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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