MCID: CLC053
MIFTS: 21

Colchicine Poisoning

Categories: Rare diseases

Aliases & Classifications for Colchicine Poisoning

MalaCards integrated aliases for Colchicine Poisoning:

Name: Colchicine Poisoning 59

Characteristics:

Orphanet epidemiological data:

59
colchicine poisoning
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

ICD10 via Orphanet 34 T50.4
Orphanet 59 ORPHA31824

Summaries for Colchicine Poisoning

MalaCards based summary : Colchicine Poisoning is related to gout and familial mediterranean fever. An important gene associated with Colchicine Poisoning is TUBB1 (Tubulin Beta 1 Class VI). Affiliated tissues include heart, kidney and bone, and related phenotypes are hypotension and dehydration

Related Diseases for Colchicine Poisoning

Diseases related to Colchicine Poisoning via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 gout 10.4
2 familial mediterranean fever 10.2
3 adult respiratory distress syndrome 10.1
4 diarrhea 10.1
5 gastroenteritis 10.1
6 respiratory failure 10.0
7 pancytopenia 10.0
8 myopathy 10.0
9 ileus 10.0
10 paralytic ileus 10.0
11 cardiogenic shock 10.0
12 pulmonary hypertension, primary, 1 9.9
13 diarrhea 9 9.9
14 bone resorption disease 9.9
15 chondrocalcinosis 9.9
16 neutropenia 9.9
17 bronchopneumonia 9.9
18 acute kidney tubular necrosis 9.9
19 polyneuropathy 9.9
20 hyperuricemia 9.9
21 lactic acidosis 9.9
22 interstitial myocarditis 9.9
23 myocarditis 9.9
24 peritonitis 9.9
25 neuropathy 9.9
26 alopecia 9.9
27 acute respiratory distress syndrome 9.9
28 wallerian degeneration 9.9

Graphical network of the top 20 diseases related to Colchicine Poisoning:



Diseases related to Colchicine Poisoning

Symptoms & Phenotypes for Colchicine Poisoning

Human phenotypes related to Colchicine Poisoning:

59 32 (show all 29)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypotension 59 32 hallmark (90%) Very frequent (99-80%) HP:0002615
2 dehydration 59 32 hallmark (90%) Very frequent (99-80%) HP:0001944
3 vomiting 59 32 hallmark (90%) Very frequent (99-80%) HP:0002013
4 respiratory distress 59 32 hallmark (90%) Very frequent (99-80%) HP:0002098
5 leukocytosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0001974
6 metabolic acidosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0001942
7 nausea 59 32 hallmark (90%) Very frequent (99-80%) HP:0002018
8 reduced consciousness/confusion 59 32 frequent (33%) Frequent (79-30%) HP:0004372
9 renal insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0000083
10 hypophosphatemia 59 32 frequent (33%) Frequent (79-30%) HP:0002148
11 hypokalemia 59 32 frequent (33%) Frequent (79-30%) HP:0002900
12 arrhythmia 59 32 frequent (33%) Frequent (79-30%) HP:0011675
13 congestive heart failure 59 32 frequent (33%) Frequent (79-30%) HP:0001635
14 lactic acidosis 59 32 frequent (33%) Frequent (79-30%) HP:0003128
15 hypocalcemia 59 32 frequent (33%) Frequent (79-30%) HP:0002901
16 hyponatremia 59 32 frequent (33%) Frequent (79-30%) HP:0002902
17 diarrhea 59 32 frequent (33%) Frequent (79-30%) HP:0002014
18 myocarditis 59 32 frequent (33%) Frequent (79-30%) HP:0012819
19 hypovolemia 59 32 frequent (33%) Frequent (79-30%) HP:0011106
20 oliguria 59 32 frequent (33%) Frequent (79-30%) HP:0100520
21 acute encephalopathy 59 32 frequent (33%) Frequent (79-30%) HP:0006846
22 hypomagnesemia 59 32 frequent (33%) Frequent (79-30%) HP:0002917
23 disseminated intravascular coagulation 59 32 frequent (33%) Frequent (79-30%) HP:0005521
24 cardiorespiratory arrest 59 32 frequent (33%) Frequent (79-30%) HP:0006543
25 cardiogenic shock 59 32 frequent (33%) Frequent (79-30%) HP:0030149
26 alopecia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001596
27 abnormality of blood and blood-forming tissues 59 Frequent (79-30%)
28 abnormality of ion homeostasis 59 Frequent (79-30%)
29 abnormality of acid-base homeostasis 59 Frequent (79-30%)

Drugs & Therapeutics for Colchicine Poisoning

Search Clinical Trials , NIH Clinical Center for Colchicine Poisoning

Genetic Tests for Colchicine Poisoning

Anatomical Context for Colchicine Poisoning

MalaCards organs/tissues related to Colchicine Poisoning:

41
Heart, Kidney, Bone, Bone Marrow

Publications for Colchicine Poisoning

Articles related to Colchicine Poisoning:

(show top 50) (show all 109)
# Title Authors PMID Year
1
Clinical outcomes after colchicine overdose: A case report. 38
31348292 2019
2
Acute Colchicine Poisoning Causes Endotoxemia via the Destruction of Intestinal Barrier Function: The Curative Effect of Endotoxin Prevention in a Murine Model. 38
31312993 2019
3
Colchicine Extract Suicidal Lethal Poisoning Confirmation Using High-Resolution Accurate Mass Spectrometry: A Case Study. 38
30536549 2019
4
Rapid identification of Gloriosa superba and Colchicum autumnale by melting curve analysis: application to a suicide case involving massive ingestion of G. superba. 38
31028469 2019
5
Two fatal intoxications by colchicine taken for saffron. Clinical, medico-legal and forensic toxicological implications. 38
30991227 2019
6
A rare case report of heavy dose colchicine induced acute kidney injury. 38
30376897 2018
7
Anti-colchicine Fab fragments prevent lethal colchicine toxicity in a porcine model: a pharmacokinetic and clinical study. 38
29334816 2018
8
A critically ill patient after a colchicine overdose below the lethal dose: a case report. 38
29970148 2018
9
LC-MS/MS quantification of free and Fab-bound colchicine in plasma, urine and organs following colchicine administration and colchicine-specific Fab fragments treatment in Göttingen minipigs. 38
28667924 2017
10
Evaluation of the Colchicine Poisoning Cases in a Pediatric Intensive Care Unit: Five Year Study. 38
27727039 2017
11
Anagen Effluvium Following Acute Colchicine Poisoning. 38
28442873 2016
12
Assessment of 17 Pediatric Cases With Colchicine Poisoning in a 2-Year Period. 38
26928096 2016
13
Progressive Organ Failure After Ingestion of Wild Garlic Juice. 38
26281812 2016
14
An Insidious Danger in Children With Familial Mediterranean Fever: Colchicine Intoxication. 38
26335230 2015
15
Acute colchicine intoxication complicated with complete AV block. 38
27186705 2015
16
Extracorporeal life support in the treatment of colchicine poisoning. 38
26230148 2015
17
Fatal colchicine poisoning by accidental ingestion of Colchicum persicum: a case report. 38
24196723 2013
18
Rugged and accurate quantitation of colchicine in human plasma to support colchicine poisoning monitoring by using turbulent-flow LC-MS/MS analysis. 38
24295116 2013
19
Colchicine poisoning: defusing the ticking time bomb. 38
23474521 2013
20
Colchicine intoxication: a report of two suicide cases. 38
24353429 2013
21
Colchicine poisoning: a case report and review of literature. 38
22941521 2012
22
[Severe myopathy related to colchicine poisoning: a case report]. 38
23241260 2012
23
Fatal poisoning in children: acute colchicine intoxication and new treatment approaches. 38
21910646 2011
24
Suicidal plant poisoning with Colchicum autumnale. 38
21771560 2011
25
Survival case of colchicine intoxication following ingestion of a lethal dose. 38
21268452 2010
26
Multiple organ failure after an overdose of less than 0.4 mg/kg of colchicine: role of coingestants and drugs during intensive care management. 38
20969505 2010
27
Colchicine poisoning: the dark side of an ancient drug. 38
20586571 2010
28
[Fatal colchicine poisoning--case report and review of literature]. 38
21387793 2010
29
A fatal case of autumn crocus (Colchicum autumnale) poisoning in a heifer: confirmation by mass-spectrometric colchicine detection. 38
20093699 2010
30
[Colchicine poisoning: a case report]. 38
19789133 2009
31
Colchicine intoxication and infection risk: a case report. 38
18613863 2008
32
[Acute colchicine poisoning by plant ingestions]. 38
17784565 2007
33
Acute colchicine intoxication in a child: a case report. 38
17505274 2007
34
Colchicine poisoning in a very young child. 38
17013492 2006
35
Fatal colchicine poisoning by accidental ingestion of meadow saffron-case report. 38
15749368 2005
36
Accidental intravenous colchicine poisoning. 38
15570196 2004
37
Colchicine poisoning: case report of two suicides. 38
15240048 2004
38
Four children with colchicine poisoning. 38
15311853 2004
39
Acute poisoning with autumn crocus (Colchicum autumnale L.). 38
15088997 2004
40
Case report: fatal poisoning with Colchicum autumnale. 38
14975056 2004
41
Accidental colchicine poisoning in a dog. 38
14992256 2004
42
Fab antibody fragments: some applications in clinical toxicology. 38
15554746 2004
43
Multiple organ failure in a kidney transplant patient receiving both colchicine and cyclosporine. 38
12832745 2003
44
Colchicine poisoning resulting from accidental ingestion of meadow saffron (Colchicum autumnale). 38
12455670 2002
45
[Colchicine poisoning by accidental ingestion of the bulbs of Sandersonia aurantiaca: report of a case]. 38
12607936 2002
46
Accidental plant poisoning with Colchicum autumnale: report of two cases. 38
11740853 2001
47
Colchicine poisoning: case report of two homicides. 38
11394761 2001
48
Comparison of enterotoxicity between autumn crocus (Colchicum autumnale L.) and colchicine in the guinea pig and mouse : enterotoxicity in the guinea pig differs from that in the mouse. 38
10993176 2000
49
Colchicine-induced bone marrow suppression: treatment with granulocyte colony-stimulating factor. 38
10802421 2000
50
[Acute colchicine poisoning]. 38
10829476 2000

Variations for Colchicine Poisoning

Expression for Colchicine Poisoning

Search GEO for disease gene expression data for Colchicine Poisoning.

Pathways for Colchicine Poisoning

GO Terms for Colchicine Poisoning

Sources for Colchicine Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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