MCID: CLD011
MIFTS: 40

Cold Urticaria

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Cold Urticaria

MalaCards integrated aliases for Cold Urticaria:

Name: Cold Urticaria 54 56 17
Primary Idiopathic Cold Urticaria 54
Urticaria Idiopathic Cold 54
Cold Contact Urticaria 54
Urticaria Due to Cold 74

Classifications:



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ICD10 34 L50.2 L50.9
UMLS 74 C0221207

Summaries for Cold Urticaria

NIH Rare Diseases : 54 Cold urticaria is a condition that affects the skin. Signs and symptoms generally include reddish, itchy welts (hives) and/or swelling when skin is exposed to the cold (i.e. cold weather or swimming in cold water). This rash is usually apparent within 2-5 minutes after exposure and can last for 1-2 hours. The exact cause of cold urticaria is poorly understood in most cases. Rarely, it may be associated with an underlying blood condition or infectious disease. Treatment generally consists of patient education, avoiding exposures that may trigger a reaction, and/or medications.

MalaCards based summary : Cold Urticaria, also known as primary idiopathic cold urticaria, is related to familial cold autoinflammatory syndrome 1 and familial cold autoinflammatory syndrome. An important gene associated with Cold Urticaria is NLRP3 (NLR Family Pyrin Domain Containing 3), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and IL1 and megakaryocytes in obesity. The drugs Histamine and Loratadine have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and neutrophil, and related phenotype is hematopoietic system.

Wikipedia : 77 Cold urticaria (essentially meaning cold hives) is a disorder where hives (urticaria) or large red welts... more...

Related Diseases for Cold Urticaria

Diseases related to Cold Urticaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 familial cold autoinflammatory syndrome 1 33.8 IL1R1 NLRP3
2 familial cold autoinflammatory syndrome 33.3 NLRP3 PLCG2
3 muckle-wells syndrome 32.6 IL1R1 NLRP3
4 urticaria 31.4 CMA1 NLRP3 PLCG2 RNASE3
5 cinca syndrome 30.1 IL1R1 NLRP3
6 joint disorders 29.6 IL1R1 IL1RAPL2
7 wells syndrome 29.2 IL1R1 IL1RAPL2 NLRP3 RNASE3
8 familial cold autoinflammatory syndrome 3 12.0
9 conjunctivitis 10.3 NLRP3 RNASE3
10 blepharoconjunctivitis 10.3 CMA1 RNASE3
11 cryopyrin-associated periodic syndrome 10.3 IL1R1 NLRP3
12 vulvar vestibulitis syndrome 10.3 IL1R1 NLRP3
13 pfeiffer syndrome 10.3
14 schnitzler syndrome 10.2 IL1R1 NLRP3
15 chronic conjunctivitis 10.2 CMA1 RNASE3
16 conjunctival disease 10.2 NLRP3 RNASE3
17 cryoglobulinemia 10.2
18 aseptic meningitis 10.2 IL1R1 NLRP3
19 vernal conjunctivitis 10.2 CMA1 RNASE3
20 cholinergic urticaria 10.2
21 purpura 10.2
22 vasculitis 10.2
23 cellulitis 10.1 IL1R1 RNASE3
24 pleuropneumonia 10.1 IL1R1 SERPINC1
25 common cold 10.1 IL1R1 RNASE3
26 leech infestation 10.1 PF4 SERPINC1
27 mitral valve stenosis 10.0 PF4 SERPINC1
28 intestinal impaction 10.0 SERPINC1 SERPINF2
29 alpha-2-plasmin inhibitor deficiency 10.0 SERPINC1 SERPINF2
30 intracranial embolism 10.0 SERPINC1 SERPINF2
31 giant hemangioma 10.0 SERPINC1 SERPINF2
32 human immunodeficiency virus infectious disease 10.0
33 korean hemorrhagic fever 10.0 SERPINC1 SERPINF2
34 marantic endocarditis 10.0 SERPINC1 SERPINF2
35 psoriasis 10.0
36 livedoid vasculitis 10.0 SERPINC1 SERPINF2
37 purpura fulminans 10.0 SERPINC1 SERPINF2
38 thrombophlebitis 10.0 SERPINC1 SERPINF2
39 blood coagulation disease 9.9 PF4 SERPINC1
40 rubeosis iridis 9.9 PF4 SERPINF2
41 angina pectoris 9.9 SERPINC1 SERPINF2
42 leukemia, chronic lymphocytic 2 9.9
43 cryoglobulinemia, familial mixed 9.9
44 leukemia, chronic lymphocytic 9.9
45 urticaria, aquagenic 9.9
46 celiac disease 1 9.9
47 complement component 2 deficiency 9.9
48 mycosis fungoides 9.9
49 hepatitis c virus 9.9
50 hepatitis 9.9

Graphical network of the top 20 diseases related to Cold Urticaria:



Diseases related to Cold Urticaria

Symptoms & Phenotypes for Cold Urticaria

MGI Mouse Phenotypes related to Cold Urticaria:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.1 CMA1 IL1R1 NLRP3 PF4 PLCG2 SERPINC1

Drugs & Therapeutics for Cold Urticaria

Drugs for Cold Urticaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4,Phase 2 51-45-6 774
2
Loratadine Approved, Investigational Phase 4 79794-75-5 3957
3
Desloratadine Approved, Investigational Phase 4 100643-71-8 124087
4 Dermatologic Agents Phase 4,Phase 2
5 Neurotransmitter Agents Phase 4,Phase 2
6 Histamine Antagonists Phase 4,Phase 2
7
Histamine Phosphate Phase 4,Phase 2 51-74-1 65513
8 Cholinergic Antagonists Phase 4
9 Antipruritics Phase 4,Phase 2
10 Histamine H1 Antagonists Phase 4,Phase 2
11 Anti-Allergic Agents Phase 4,Phase 2
12 Cholinergic Agents Phase 4
13 Histamine H1 Antagonists, Non-Sedating Phase 4
14
Rilonacept Approved, Investigational Phase 3,Phase 2 501081-76-1 104924
15 Anti-Inflammatory Agents Phase 3,Phase 2
16 Antibodies Phase 3,Phase 2
17 Antibodies, Monoclonal Phase 3,Phase 2
18 Immunoglobulins Phase 3,Phase 2
19 Immunologic Factors Phase 3,Phase 2
20
Cyproheptadine Approved Phase 2 129-03-3 2913
21
Omalizumab Approved, Investigational Phase 2 242138-07-4
22 Gastrointestinal Agents Phase 2
23 Serotonin Antagonists Phase 2
24 Serotonin Agents Phase 2
25 Anti-Asthmatic Agents Phase 2
26 Respiratory System Agents Phase 2
27
Serotonin Investigational, Nutraceutical Phase 2 50-67-9 5202
28 Antirheumatic Agents Phase 1
29 Interleukin 1 Receptor Antagonist Protein Phase 1

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Desloratadine 5, 10 and 20mg in Patients With Cold Urticaria Completed NCT01444196 Phase 4 Desloratadine
2 A Study to Assess and Compare the Effects of 5 mg vs. 20 mg Desloratadine on the Development of Cold Urticaria Lesions Completed NCT00600847 Phase 4 desloratadine;desloratadine;placebo
3 Bilastine Updosing - Characterization of Underlying Mechanisms Completed NCT01271075 Phase 2, Phase 3 Bilastine;Bilastine
4 Rilonacept for Treatment of Cryopyrin-Associated Periodic Syndromes (CAPS) Completed NCT00288704 Phase 3 rilonacept 160 mg;Placebo;rilonacept 160 mg
5 The Safety and Efficacy of Canakinumab in Patients Aged 4 Years or Older Diagnosed With Cryopyrin-associated Periodic Syndromes (CAPS) in Canada Completed NCT01105507 Phase 3 canakinumab (company code: ACZ885D)
6 Study to Assess Efficacy, Safety and Mechanism of Rupatadine in Cold Urticaria Completed NCT01605487 Phase 2 Rupatadine;Rupatadine;Rupatadine;Rupatadine;Rupatadine;Rupatadine
7 Cold Urticaria Treatment With Xolair Completed NCT01580592 Phase 2 Omalizumab;Omalizumab;Placebo
8 Cold Contact Urticaria Treatment With Rilonacept Completed NCT02171416 Phase 2 Rilonacept;Placebo
9 The Use of Kineret (Anakinra) in the Treatment of Familial Cold Urticaria Completed NCT00214851 Phase 1 Kineret (anakinra)
10 Study to Investigate Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of GSK2646264 Completed NCT02424799 Phase 1 GSK2646264 0.5% topical cream;GSK2646264 1% topical cream;Placebo
11 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Completed NCT00933296
12 Validation of an Urticaria Control Test Completed NCT01614834
13 Development of an Urticaria Control Test Completed NCT01610128
14 Pathogenesis of Physical Induced Urticarial Syndromes Recruiting NCT00887939

Search NIH Clinical Center for Cold Urticaria

Genetic Tests for Cold Urticaria

Anatomical Context for Cold Urticaria

MalaCards organs/tissues related to Cold Urticaria:

42
Skin, Testes, Neutrophil, B Cells

Publications for Cold Urticaria

Articles related to Cold Urticaria:

(show top 50) (show all 249)
# Title Authors Year
1
JAAD Game Changers: Acquired cold urticaria: Clinical features, particular phenotypes, and disease course in a tertiary care center cohort. ( 30447322 )
2019
2
H1-antihistamine inhibition of histamine- and codeine-induced wheals does not predict response in chronic cold urticaria. ( 30708143 )
2019
3
Treatments of Cold Urticaria: A Systematic Review. ( 30776418 )
2019
4
Benefit from reslizumab treatment in a patient with chronic spontaneous urticaria and cold urticaria. ( 28924988 )
2018
5
Successful Minimally Invasive Mitral Valve Replacement Using Normothermic Fibrillatory Arrest in a Patient With Cold Urticaria. ( 28967621 )
2018
6
Food-dependent cold urticaria: A new variant of physical urticaria. ( 29698807 )
2018
7
Clinical and Genetic Features of Familial Cold Urticaria: A Report of Three Families. ( 30246732 )
2018
8
Post-infectious sensory neuropathy with anti-GT1a and GQ1b antibodies associated with cold urticaria. ( 30318072 )
2018
9
Anaphylaxis in atypical cold urticaria: case report and review of literature. ( 30424814 )
2018
10
Patients with chronic cold urticaria may benefit from doxycycline therapy. ( 27343477 )
2017
11
Omalizumab is effective in cold urticaria-results of a randomized placebo-controlled trial. ( 28389393 )
2017
12
Perioperative Management of a Patient with Cold Urticaria. ( 29326933 )
2017
13
Rupatadine 20 mg and 40 mg are Effective in Reducing the Symptoms of Chronic Cold Urticaria. ( 26038847 )
2016
14
Diagnosis and management of cold urticaria. ( 26919357 )
2016
15
Cold urticaria: a 20-year follow-up study. ( 27422852 )
2016
16
Acquired cold urticaria: Clinical features, particular phenotypes, and disease course in a tertiary care center cohort. ( 27485164 )
2016
17
Localized facial cold urticaria. ( 25951754 )
2015
18
Familial atypical cold urticaria localized on the face: a case report. ( 23695027 )
2014
19
Idiopathic cold urticaria and anaphylaxis. ( 24378859 )
2014
20
Kounis syndrome following cold urticaria: the swimmer's death. ( 25064198 )
2014
21
Rhabdomyolysis-induced transient cold urticaria. ( 25179913 )
2014
22
Danazol in the treatment of refractory acquired cold urticaria. ( 25399791 )
2014
23
Effective treatment of idiopathic chronic cold urticaria with omalizumab: report of 3 cases. ( 23866899 )
2013
24
Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. ( 22236196 )
2012
25
Critical temperature threshold measurement for cold urticaria: a randomized controlled trial of H(1) -antihistamine dose escalation. ( 22242678 )
2012
26
Cold urticaria patients exhibit normal skin levels of functional mast cells and histamine after tolerance induction. ( 22398751 )
2012
27
Cold urticaria induced by alprazolam. ( 22697016 )
2012
28
A case of combined cholinergic and cold urticaria. ( 23269894 )
2012
29
Dermacase. Question: Can you identify this condition? Acquired cold urticaria. ( 21490359 )
2011
30
Results and relevance of critical temperature threshold testing in patients with acquired cold urticaria. ( 19785601 )
2010
31
Rupatadine and its effects on symptom control, stimulation time, and temperature thresholds in patients with acquired cold urticaria. ( 20143651 )
2010
32
Treatment of cold urticaria. ( 20425002 )
2010
33
Efficacy and tolerability of second- and third-generation antihistamines in the treatment of acquired cold urticaria: a meta-analysis. ( 20568385 )
2010
34
Localized cold urticaria to the face in a pediatric patient: a case report and literature review. ( 20609144 )
2010
35
Cold urticaria: its importance in the operating room. ( 20945615 )
2010
36
Treatment of acquired cold urticaria with rupatadine. ( 19392988 )
2009
37
Complete remission of severe idiopathic cold urticaria on interleukin-1 receptor antagonist (anakinra). ( 19841487 )
2009
38
Familial atypical cold urticaria: description of a new hereditary disease. ( 19910034 )
2009
39
High-dose desloratadine decreases wheal volume and improves cold provocation thresholds compared with standard-dose treatment in patients with acquired cold urticaria: a randomized, placebo-controlled, crossover study. ( 19201016 )
2009
40
Cold urticaria and celiac disease. ( 18447142 )
2008
41
Clinical features and natural history of acquired cold urticaria in a tertiary referral hospital: a 10-year prospective study. ( 19120806 )
2008
42
Histamine, but not leukotriene C4, is an essential mediator in cold urticaria wheals. ( 17225008 )
2007
43
A potential new therapy for cold urticaria and chronic idiopathic urticaria. ( 17291869 )
2007
44
Acquired cold urticaria: clinical picture and update on diagnosis and treatment. ( 17355280 )
2007
45
Cold urticaria: tolerance induction with cold baths. ( 17711531 )
2007
46
Acquired cold urticaria symptoms can be safely prevented by ebastine. ( 17900265 )
2007
47
Cold temperature challenges for acquired cold urticaria. ( 15867876 )
2005
48
Cold urticaria associated with acute serologic toxoplasmosis. ( 15946632 )
2005
49
Cold urticaria; disease course and outcome--an investigation of 85 patients before and after therapy. ( 16086764 )
2005
50
Cold urticaria: an under-recognized cause of postsurgical periorbital swelling. ( 16234692 )
2005

Variations for Cold Urticaria

Expression for Cold Urticaria

Search GEO for disease gene expression data for Cold Urticaria.

Pathways for Cold Urticaria

GO Terms for Cold Urticaria

Cellular components related to Cold Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.55 CMA1 PF4 RNASE3 SERPINC1 SERPINF2
2 platelet alpha granule lumen GO:0031093 9.26 PF4 SERPINF2
3 collagen-containing extracellular matrix GO:0062023 9.26 CMA1 PF4 SERPINC1 SERPINF2
4 extracellular region GO:0005576 9.17 CMA1 IL1R1 NLRP3 PF4 RNASE3 SERPINC1

Biological processes related to Cold Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.43 IL1R1 NLRP3 PF4
2 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.16 PF4 RNASE3
3 cytokine-mediated signaling pathway GO:0019221 9.13 IL1R1 IL1RAPL2 PF4
4 regulation of inflammatory response GO:0050727 8.8 CMA1 IL1R1 NLRP3

Molecular functions related to Cold Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.13 IL1R1 SERPINC1 SERPINF2
2 interleukin-1 receptor activity GO:0004908 8.62 IL1R1 IL1RAPL2

Sources for Cold Urticaria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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