MCID: CLD011
MIFTS: 34

Cold Urticaria

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Cold Urticaria

MalaCards integrated aliases for Cold Urticaria:

Name: Cold Urticaria 52 54 17
Primary Idiopathic Cold Urticaria 52
Urticaria Idiopathic Cold 52
Cold Contact Urticaria 52
Urticaria Due to Cold 71

Classifications:



External Ids:

UMLS 71 C0221207

Summaries for Cold Urticaria

NIH Rare Diseases : 52 Cold urticaria is a condition that affects the skin. Signs and symptoms generally include reddish, itchy welts (hives ) and/or swelling when skin is exposed to the cold (i.e. cold weather or swimming in cold water). This rash is usually apparent within 2-5 minutes after exposure and can last for 1-2 hours. The exact cause of cold urticaria is poorly understood in most cases. Rarely, it may be associated with an underlying blood condition or infectious disease . Treatment generally consists of patient education, avoiding exposures that may trigger a reaction, and/or medications.

MalaCards based summary : Cold Urticaria, also known as primary idiopathic cold urticaria, is related to familial cold autoinflammatory syndrome 1 and familial cold autoinflammatory syndrome. An important gene associated with Cold Urticaria is NLRP3 (NLR Family Pyrin Domain Containing 3), and among its related pathways/superpathways are Shigellosis and Formation of Fibrin Clot (Clotting Cascade). The drugs Desloratadine and Loratadine have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and neutrophil.

Wikipedia : 74 Cold urticaria (essentially meaning cold hives) is a disorder where hives (urticaria) or large red welts... more...

Related Diseases for Cold Urticaria

Diseases related to Cold Urticaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
# Related Disease Score Top Affiliating Genes
1 familial cold autoinflammatory syndrome 1 34.0 NLRP3 IL1R1
2 familial cold autoinflammatory syndrome 32.7 PLCG2 NLRP3 IL1RAPL2 IL1R1
3 muckle-wells syndrome 32.3 NLRP3 IL1RAPL2 IL1R1
4 urticaria 31.1 RNASE3 PLCG2 NLRP3 CMA1
5 physical urticaria 30.9 PLCG2 NLRP3
6 autoinflammatory syndrome 30.0 PLCG2 NLRP3
7 cellulitis 29.9 RNASE3 IL1R1
8 common cold 29.9 RNASE3 IL1R1
9 wells syndrome 29.6 RNASE3 NLRP3 IL1RAPL2 IL1R1
10 cinca syndrome 29.0 PLCG2 NLRP3 IL1RAPL2 IL1R1
11 dermatitis, atopic 28.8 RNASE3 PF4 CMA1
12 familial cold autoinflammatory syndrome 3 12.5
13 angioedema 10.5
14 cryoglobulinemia 10.4
15 purpura 10.4
16 pfeiffer syndrome 10.3
17 ige responsiveness, atopic 10.3
18 vasculitis 10.3
19 cholinergic urticaria 10.3
20 vulvar vestibulitis syndrome 10.3 NLRP3 IL1R1
21 cryopyrin-associated periodic syndrome 10.3 NLRP3 IL1R1
22 blepharoconjunctivitis 10.3 RNASE3 CMA1
23 vasomotor rhinitis 10.2 RNASE3 CMA1
24 chronic conjunctivitis 10.2 RNASE3 CMA1
25 conjunctival disease 10.2 RNASE3 NLRP3
26 exanthem 10.2
27 status asthmaticus 10.2 RNASE3 IL1R1
28 pyoderma 10.2 NLRP3 IL1R1
29 pyoderma gangrenosum 10.2 NLRP3 IL1R1
30 aseptic meningitis 10.1 NLRP3 IL1R1
31 adult-onset still's disease 10.1 IL1RAPL2 IL1R1
32 dengue shock syndrome 10.1 IL1RAPL2 CMA1
33 autoimmune disease 10.0
34 urticaria, aquagenic 10.0
35 telangiectasis 10.0
36 dermatitis 10.0
37 syphilis 10.0
38 rhinitis 10.0
39 polycythemia 10.0
40 measles 10.0
41 chickenpox 10.0
42 amyloidosis 10.0
43 pustulosis of palm and sole 10.0
44 psoriasis 10.0
45 schnitzler syndrome 9.9 NLRP3 IL1RAPL2 IL1R1
46 amyotrophic lateral sclerosis 1 9.9
47 gastroesophageal reflux 9.9
48 complement component 4, partial deficiency of 9.9
49 cryoglobulinemia, familial mixed 9.9
50 factor viii deficiency 9.9

Graphical network of the top 20 diseases related to Cold Urticaria:



Diseases related to Cold Urticaria

Symptoms & Phenotypes for Cold Urticaria

Drugs & Therapeutics for Cold Urticaria

Drugs for Cold Urticaria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Desloratadine Approved, Investigational Phase 4 100643-71-8 124087
2
Loratadine Approved, Investigational Phase 4 79794-75-5 3957
3 Cholinergic Agents Phase 4
4 Cholinergic Antagonists Phase 4
5 Histamine H1 Antagonists, Non-Sedating Phase 4
6
Histamine Approved, Investigational Phase 3 51-45-6 774
7
Cyproheptadine Approved Phase 3 129-03-3 2913
8 Antibodies, Monoclonal Phase 3
9 Antibodies Phase 3
10 Immunoglobulins Phase 3
11 Neurotransmitter Agents Phase 3
12 Dermatologic Agents Phase 3
13 Histamine Antagonists Phase 3
14 Serotonin Agents Phase 3
15 Histamine H1 Antagonists Phase 3
16 Serotonin Antagonists Phase 3
17 Anti-Allergic Agents Phase 3
18 Antipruritics Phase 3
19
Histamine Phosphate Phase 3 51-74-1 65513
20
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
21
Rilonacept Approved, Investigational Phase 2 501081-76-1 104924
22
Omalizumab Approved, Investigational Phase 2 242138-07-4
23 Anti-Asthmatic Agents Phase 2
24 Respiratory System Agents Phase 2
25 Vaccines Phase 2
26 Interleukin 1 Receptor Antagonist Protein Phase 1

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Multi-center, Double Blind, Dose Escalating Study to Compare the Effects of 5 mg, 10mg and 20mg of Desloratadine in Patients With Acquired Cold Urticaria (ACU) Completed NCT01444196 Phase 4 Desloratadine
2 An Exploratory Phase IV, Randomised, Double-Blind, Placebo Controlled Crossover Study to Compare the Effects of 5 mg vs. 20 mg Desloratadine on the Development of Experimentally Induced Urticaria Lesions Completed NCT00600847 Phase 4 desloratadine;desloratadine;placebo
3 Double-blind, Triple Cross-over, Placebo-controlled Study to Assess the Efficacy, Mechanisms, and Safety of Treatment With Bilastine 20 mg, 40 mg and 80 mg in Cold Contact Urticaria (CCU) Completed NCT01271075 Phase 2, Phase 3 Bilastine;Bilastine
4 An Open Label Study to Assess the Safety, Tolerability and Efficacy of Canakinumab (ACZ885) in Patients Aged 4 Years or Older Diagnosed With Cryopyrin-associated Periodic Syndromes (CAPS) in Canada Completed NCT01105507 Phase 3 canakinumab (company code: ACZ885D)
5 A Multi-center, Randomized, Double Blind, Dose Escalating Phase III Study on the Efficacy, Safety and Long Term Outcome of Continuous vs. on Demand Treatment of Chronic Spontaneous Urticaria With Rupatadine. Terminated NCT02358265 Phase 3 10 mg Rupatadine on demand;10 mg Rupatadine;20 mg Rupatadine;10 mg Rupatadine on demand (sham updosing to 20 mg)
6 A 6 Week Randomized, Double Blind, Placebo-controlled Study With a 6 Week Open Label Extension to Assess the Efficacy of Etanercept in the Treatment of Chronic Idiopathic Urticaria Withdrawn NCT01030120 Phase 2, Phase 3 etanercept;placebo
7 A Single-center, Double-blind Placebo-controlled Parallel Group Phase II Study of the Efficacy and Safety of Rilonacept in Subjects With Cold Contact Urticaria (CCU) Completed NCT02171416 Phase 2 Rilonacept;Placebo
8 Double-blind, Three-way Cross-over, Placebo-controlled Study to Assess the Efficacy, Safety and Mechanisms of Treatment With Rupatadine 20 mg and 40 mg in Cold Contact Urticaria (CCU) Completed NCT01605487 Phase 2 Rupatadine;Rupatadine;Rupatadine;Rupatadine;Rupatadine;Rupatadine
9 A Two-center, Double Blind, Placebo-controlled Study in Parallel Design to Assess the Efficacy and Safety of 150 and 300 mg Omalizumab in Subjects With Antihistamine-resistant Cold Contact Urticaria (CCU) Completed NCT01580592 Phase 2 Omalizumab;Omalizumab;Placebo
10 Multicenter Randomized, Double-blind, Placebo-controlled Parallel Clinical Trial to Assess Efficacy and Safety of Omalizumab (Xolair®) in a New Indication: Cholinergic Urticarial Completed NCT02012387 Phase 2
11 The Use of Kineret (Anakinra) in the Treatment of Familial Cold Urticaria Completed NCT00214851 Phase 1 Kineret (anakinra)
12 A Randomised Double Blind (Sponsor Unblinded), Single and Repeat Ascending Dose First Time in Human Study in Healthy Subjects, Cold Urticaria and Chronic Spontaneous Urticaria Subjects to Investigate Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of GSK2646264 Completed NCT02424799 Phase 1 GSK2646264 0.5% topical cream;GSK2646264 1% topical cream;Placebo
13 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Completed NCT00933296
14 Pathogenesis and Genetic Basis of Physical Induced Urticarial Syndromes Recruiting NCT00887939

Search NIH Clinical Center for Cold Urticaria

Genetic Tests for Cold Urticaria

Anatomical Context for Cold Urticaria

MalaCards organs/tissues related to Cold Urticaria:

40
Skin, Testes, Neutrophil, Thyroid, Endothelial

Publications for Cold Urticaria

Articles related to Cold Urticaria:

(show top 50) (show all 447)
# Title Authors PMID Year
1
Eosinophil cationic protein (ECP) level and its correlation with eosinophil number or IgE level of peripheral blood in patients with various skin diseases. 61 54
9279689 1997
2
Cold urticaria as a model of mediator release: platelet factor 4, eosinophil cationic protein and histamine. 54 61
1280916 1992
3
[Cold urticaria and coeliac disease in a paediatric patient]. 61
30837113 2019
4
Acquired Cold Urticaria vs. Autoinflammatory Diseases, Genetic and Clinical Profile and Differential Diagnosis: Study of a Cohort of Patients in a Tertiary Reference Centre. 61
31408184 2019
5
PLAID syndrome: Characteristic presentation and a novel therapeutic option. 61
31633221 2019
6
Rapid disappearance of both severe atopic dermatitis and cold urticaria following dupilumab treatment. 61
31437869 2019
7
Management problems in severe chronic inducible urticaria: Two case reports. 61
31384330 2019
8
Cold Urticaria: Clinical Features and Natural Course in a Tropical Country. 61
31172722 2019
9
H1-antihistamine inhibition of histamine- and codeine-induced wheals does not predict response in chronic cold urticaria. 61
30708143 2019
10
JAAD Game Changers: Acquired cold urticaria: Clinical features, particular phenotypes, and disease course in a tertiary care center cohort. 61
30447322 2019
11
Treatments of cold urticaria: A systematic review. 61
30776418 2019
12
Anaphylaxis in atypical cold urticaria: case report and review of literature. 61
30424814 2018
13
Post-infectious sensory neuropathy with anti-GT1a and GQ1b antibodies associated with cold urticaria. 61
30318072 2018
14
Clinical and Genetic Features of Familial Cold Urticaria: A Report of Three Families. 61
30246732 2018
15
How to Approach Chronic Inducible Urticaria. 61
30033913 2018
16
Food-dependent cold urticaria: A new variant of physical urticaria. 61
29698807 2018
17
An unusual hazard of menopause in the workplace: a case report. 61
29609500 2018
18
Chronic inducible urticaria: A systematic review of treatment options. 61
29438771 2018
19
[NLRC4 associated autoinflammatory diseases: A systematic review of the current literature]. 61
29496273 2018
20
[Cryopyrin-associated periodic syndromes]. 61
29111302 2018
21
Successful Minimally Invasive Mitral Valve Replacement Using Normothermic Fibrillatory Arrest in a Patient With Cold Urticaria. 61
28967621 2018
22
Benefit from reslizumab treatment in a patient with chronic spontaneous urticaria and cold urticaria. 61
28924988 2018
23
Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published evidence. 61
28751232 2018
24
Chronic spontaneous urticaria or autoinflammatory disease? The therapeutic effect of omalizumab in a pediatric patient. 61
30426806 2018
25
NLRC4 inflammasomopathies. 61
28957823 2017
26
Omalizumab is effective in cold urticaria-results of a randomized placebo-controlled trial. 61
28389393 2017
27
Prevalence of Inducible Urticaria in Patients with Chronic Spontaneous Urticaria: Associated Risk Factors. 61
27838325 2017
28
Perioperative Management of a Patient with Cold Urticaria. 61
29326933 2017
29
Patients with chronic cold urticaria may benefit from doxycycline therapy. 61
27343477 2017
30
Cold urticaria: a 20-year follow-up study. 61
27422852 2016
31
Acquired cold urticaria: Clinical features, particular phenotypes, and disease course in a tertiary care center cohort. 61
27485164 2016
32
Clinical and etiologic evaluation of the children with chronic urticaria. 61
27931300 2016
33
Cool-temperature-mediated activation of phospholipase C-γ2 in the human hereditary disease PLAID. 61
27196803 2016
34
Muckle-Wells Syndrome: A Case Report with an NLRP3 T348M Mutation. 61
27435956 2016
35
Pure Cold-Induced Cholinergic Urticaria in a Pediatric Patient. 61
28025628 2016
36
Diagnosis and management of cold urticaria. 61
26919357 2016
37
Rupatadine 20 mg and 40 mg are Effective in Reducing the Symptoms of Chronic Cold Urticaria. 61
26038847 2016
38
[A new auto-inflammatory genetic disease associated with cold urticaria: Plaid involving PLCG2 mutation]. 61
26149917 2015
39
An improved Peltier effect-based instrument for critical temperature threshold measurement in cold- and heat-induced urticaria. 61
25266078 2015
40
Deep Hypothermic Circulatory Arrest in a Patient With Cold-Induced Urticaria. 61
26234851 2015
41
PLAID: a Syndrome of Complex Patterns of Disease and Unique Phenotypes. 61
26206677 2015
42
The incidence of perioperative hypersensitivity reactions: a single-center, prospective, cohort study. 61
25902325 2015
43
Localized facial cold urticaria. 61
25951754 2015
44
Distinct Cutaneous Manifestations and Cold-Induced Leukocyte Activation Associated With PLCG2 Mutations. 61
25760457 2015
45
[Cryopyrine-associated periodic syndrome: CAPS seen from adulthood]. 61
25595876 2015
46
Update on rupatadine in the management of allergic disorders. 61
25491409 2015
47
Rhabdomyolysis-induced transient cold urticaria. 61
25179913 2014
48
[Inducible urticaria and chronic spontaneous urticaria]. 61
25539678 2014
49
[Angioedema and urticaria]. 61
25539680 2014
50
Danazol in the treatment of refractory acquired cold urticaria. 61
25399791 2014

Variations for Cold Urticaria

Expression for Cold Urticaria

Search GEO for disease gene expression data for Cold Urticaria.

Pathways for Cold Urticaria

Pathways related to Cold Urticaria according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.7 PLCG2 NLRP3 IL1R1
2
Show member pathways
11 SERPINF2 SERPINC1 PF4
3 10.35 NLRP3 IL1R1

GO Terms for Cold Urticaria

Cellular components related to Cold Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.55 SERPINF2 SERPINC1 RNASE3 PF4 CMA1
2 platelet alpha granule lumen GO:0031093 9.26 SERPINF2 PF4
3 collagen-containing extracellular matrix GO:0062023 9.26 SERPINF2 SERPINC1 PF4 CMA1
4 extracellular region GO:0005576 9.17 SERPINF2 SERPINC1 RNASE3 PF4 NLRP3 IL1R1

Biological processes related to Cold Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.13 PF4 IL1RAPL2 IL1R1
2 regulation of inflammatory response GO:0050727 8.8 NLRP3 IL1R1 CMA1

Molecular functions related to Cold Urticaria according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.13 SERPINF2 SERPINC1 IL1R1
2 interleukin-1 receptor activity GO:0004908 8.62 IL1RAPL2 IL1R1

Sources for Cold Urticaria

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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