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MCID: CLL015
MIFTS: 52

Collagen Disease

Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Collagen Disease

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MalaCards integrated aliases for Collagen Disease:

Name: Collagen Disease 12 15
Collagen Diseases 56 45 74
Collagen Disorder 12 77

External Ids:

Disease Ontology 12 DOID:854
MeSH 45 D003095
NCIt 51 C27204
SNOMED-CT 69 81573002
UMLS 74 C0009326
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Summaries for Collagen Disease

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Disease Ontology : 12 A connective tissue disease that characterized by connective tissue disease that has_material_basis in inheritable defects in collagen.

MalaCards based summary : Collagen Disease, also known as collagen diseases, is related to rheumatic disease and ehlers-danlos syndrome. An important gene associated with Collagen Disease is RPL7 (Ribosomal Protein L7), and among its related pathways/superpathways are Focal Adhesion and Collagen chain trimerization. The drugs leucovorin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and eye, and related phenotypes are no effect and integument

Wikipedia : 77 A connective tissue disease is any disease that has the connective tissues of the body as a target of... more...

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Related Diseases for Collagen Disease

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Diseases in the Collagen Disease family:

Collagen Type Vi-Related Disorders Type Ii Collagen Disorders

Diseases related to Collagen Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 rheumatic disease 31.8 CENPB SSB TOP1 TRIM21
2 ehlers-danlos syndrome 31.1 B4GALT7 COL1A2 COL3A1 COL5A1 COL5A2 PLOD1
3 systemic scleroderma 30.4 CCN2 CENPB EDN1 EXOSC10 SNRNP70 SSB
4 scleroderma, familial progressive 30.1 COL1A2 EDN1 TOP1
5 marfan syndrome 29.8 COL1A2 COL3A1 COL5A2
6 diffuse scleroderma 29.8 TOP1 TRIM21
7 connective tissue disease 28.3 CCN2 CENPB COL1A2 COL3A1 COL5A1 EDN1
8 disseminated eosinophilic collagen disease 12.3
9 type ii collagen disorders 12.1
10 alpha-2-deficient collagen disease 12.1
11 hypereosinophilic syndrome 11.1
12 mixed connective tissue disease 10.9
13 bone fragility with contractures, arterial rupture, and deafness 10.8
14 collagenopathy, types ii and xi 10.8
15 ehlers-danlos syndrome, vascular type 10.4 COL3A1 COL5A1
16 hypomelanosis of ito 10.4 COL5A1 PLOD1
17 lipoblastoma 10.3 COL1A2 COL3A1
18 larsen-like syndrome 10.3 COL1A2 COL3A1 COL5A2
19 ehlers-danlos syndrome, classic type, 2 10.3 COL3A1 COL5A1 COL5A2
20 cervical incompetence 10.3 COL5A2 PLOD1
21 crest syndrome 10.3 CENPB TOP1
22 hypermobility syndrome 10.3 COL3A1 COL5A1 TNXB
23 raynaud disease 10.3 EDN1 TOP1
24 facial hemiatrophy 10.3 EXOSC10 SNRNP70 TRIM21
25 diffuse cutaneous systemic sclerosis 10.2 CCN2 CCR6 ICOSLG
26 ehlers-danlos syndrome, classic type, 1 10.2 COL1A2 COL3A1 COL5A1 COL5A2
27 classic ehlers-danlos syndrome 10.2 COL1A2 COL5A1 COL5A2 TNXB
28 dyskinesia of esophagus 10.2 CENPB TOP1
29 lupus erythematosus 10.2
30 stiff skin syndrome 10.1 CCN2 COL1A2
31 systemic lupus erythematosus 10.1
32 caspase 8 deficiency 10.1 COL5A1 COL5A2
33 arthritis 9.9
34 pneumonia 9.9
35 polyarteritis nodosa 9.9
36 limited scleroderma 9.9 CCN2 CCR6 CENPB SNRNP70 TOP1 TSSK1B
37 autoimmune disease of musculoskeletal system 9.8 CENPB EXOSC10 SNRNP70 SSB TOP1 TRIM21
38 rheumatoid arthritis 9.8
39 rheumatic fever-related antigen 9.8
40 dermatomyositis 9.8
41 rheumatic fever 9.8
42 purpura 9.8
43 pulmonary hypertension 9.8
44 diabetes mellitus 9.8
45 hepatitis 9.8
46 liver disease 9.8
47 renal tubular acidosis 9.8
48 polymyositis 9.8
49 brittle bone disorder 9.7
50 graves' disease 9.7

Graphical network of the top 20 diseases related to Collagen Disease:



Diseases related to Collagen Disease
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Symptoms & Phenotypes for Collagen Disease

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GenomeRNAi Phenotypes related to Collagen Disease according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 B4GALT7 CCN2 CCR6 CENPB COL1A2 COL3A1

MGI Mouse Phenotypes related to Collagen Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.76 CCN2 COL1A2 COL3A1 COL5A1 COL5A2 PLOD1
2 mortality/aging MP:0010768 9.73 CCN2 CENPB COL1A2 COL3A1 COL5A1 COL5A2
3 normal MP:0002873 9.23 CCN2 CCR6 CENPB COL1A2 COL5A1 COL5A2
Sources

Drugs & Therapeutics for Collagen Disease

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Drugs for Collagen Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1028)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 143 6006
2
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1959-05-2, 59-05-2 126941
3
Sulfasalazine Approved Phase 4,Phase 3,Phase 2,Not Applicable 599-79-1 5359476 5353980
4
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 331731-18-1 16219006
5
Leflunomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 75706-12-6 3899
6
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 185243-69-0
7
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2921-57-5
8
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 302-25-0
9
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 170277-31-3
10
Ethanol Approved Phase 4,Phase 3,Phase 2,Not Applicable 64-17-5 702
11
Hydroxychloroquine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 118-42-3 3652
12
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 16590-41-3 5360515
13
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-24-8 5755
14
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 83-43-2 6741
15
Tranylcypromine Approved, Investigational Phase 4 155-09-9 441233
16
Thrombin Approved, Investigational Phase 4,Phase 2
17
Rivaroxaban Approved Phase 4,Phase 3,Not Applicable 366789-02-8
18
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1197-18-8 5526
19
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 124-94-7 31307
20
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 169590-42-5 2662
21
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 9004-61-9 53477741
22
Dalteparin Approved Phase 4,Phase 3,Not Applicable 9005-49-6
23
Enoxaparin Approved Phase 4,Phase 3,Not Applicable 9005-49-6 772
24
Heparin Approved, Investigational Phase 4,Phase 3,Not Applicable 9005-49-6 46507594 772
25
Acetylcholine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-84-3 187
26
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 15307-86-5 3033
27
Glucosamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 3416-24-8 439213
28
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 103-90-2 1983
29
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
30
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 1177-87-3
31
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
32
Ketorolac Approved Phase 4,Phase 3,Phase 2,Not Applicable 74103-06-3, 66635-83-4 3826
33
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 378-44-9 9782
34
Iron Approved, Experimental Phase 4,Phase 3,Phase 1,Phase 2 7439-89-6, 15438-31-0 27284 23925
35
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22204-53-1 156391 1302
36
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
37
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
38
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Not Applicable 84057-95-4 175805 71273
39
Fluorouracil Approved Phase 4 51-21-8 3385
40
Cimetidine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 51481-61-9 2756
41
Hyoscyamine Approved Phase 4,Not Applicable 101-31-5 64692
42
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-41-2 439260
43
Levomilnacipran Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 96847-54-0
44
Milnacipran Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 92623-85-3 65833
45
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
46
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1401-55-4
47
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 202409-33-4 123619
48
Abatacept Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 332348-12-6 10237
49
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 428863-50-7
50
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 174722-31-7 10201696

Interventional clinical trials:

(show top 50) (show all 6808)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
2 Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis Unknown status NCT02087696 Phase 4 Tocilizumab
3 Vaccination Against Pertussis, Tetanus and Diphtheria in Patients Suffering From Rheumatoid Arthritis Unknown status NCT01301703 Phase 4
4 Adalimumab in Alleviating Inflammation in Patients With Axial Spondyloarthritis Unknown status NCT02634541 Phase 4 Adalimumab
5 Efficacy Study of Leflunomide to Treat Juvenile Idiopathic Arthritis Unknown status NCT02024334 Phase 4 Leflunomide
6 Kunxian for the Treatment of Rheumatoid Arthritis Unknown status NCT02764515 Phase 4 Kunxian Capsule;Methotrexate
7 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
8 TNF-blocking Therapy in Combination With Disease-modifying Antirheumatic Drugs in Early Rheumatoid Arthritis Unknown status NCT00908089 Phase 4 Trexan+Salazopyrin+Oxiklorin+prednisolone + infliximab;Trexan+Salazopyrin+Oxiklorin+prednisolone + placebo
9 Obesity Cohort : Medical Follow-up of Severe or Morbid Obese Patients Undergoing Bariatric Surgery Unknown status NCT02310178 Phase 4
10 Very Early Versus Delayed Etanercept in Patients With RA Unknown status NCT02433184 Phase 4 Etanercept;Methotrexate;Sulfasalazine;Hydroxychloroquine;Etanercept;Methotrexate
11 Pilot Study to Evaluate Clinical Outcomes With the Use of Biovance Following Keloid Scar Revision Surgery Unknown status NCT02521402 Phase 4
12 Combined Topical Tranexamic Acid With Floseal® in Total Knee Arthroplasty Unknown status NCT03328832 Phase 4 Topical tranexamic acid;Floseal®;rivaroxaban (10mg)
13 Outcomes of Injections in Patients Waiting for Total Knee Replacement Unknown status NCT03090698 Phase 4 Hylan G-F 20;Triamcinolone
14 The Study to Evaluate Efficacy and Safety of Celecoxib Capsule in Hand Osteoarthritis Patients Unknown status NCT03067194 Phase 4 Celecoxib 100 MG;Celecoxib 200mg
15 Additional Effects of Triamcinolone to Hyaluronic Acid on Knee Osteoarthritis Unknown status NCT02949466 Phase 4 Triamcinolone
16 Topical Tranexamic Acid and Floseal® in Total Knee Arthroplasty Unknown status NCT02865174 Phase 4 Topical tranexamic acid;Floseal®;Enoxaparin
17 Influence of Perception of Patients Suffering of Knee Osteoarthritis Regarding Effectiveness of Intra-articular Injection Unknown status NCT02835521 Phase 4 Joint injection with triamcinolone hexacetonide
18 Intra-articular Botox Type A Versus Corticosteroids in Knee Osteoarthritis Unknown status NCT02829281 Phase 4 Botulinum Toxin Type A;Triamcinolone hexacetonide;Saline
19 Clinical Study of Artz in the Treatment of Knee Osteoarthritis Unknown status NCT02826031 Phase 4 Sodium Hyaluronate Injection;DICL-SR
20 Primary Care Study With Chondroitin Sulfate and Glucosamine Hydrochloride in Hand Osteoarhritis Unknown status NCT02823548 Phase 4 Droglican;Placebo
21 Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN Unknown status NCT02821468 Phase 4 Droglican;Paracetamol or oral NSAIDs excluding COX2 inhibitors
22 Effects of Perioperative Intravenous Dexamethasone on the Severity of Persistent Postsurgical Pain After Total Knee Arthroplasty : A Prospective, Randomized, Double-blind, Placebo-controlled Trial Unknown status NCT02760459 Phase 4 Dexamethasone;Normal saline solution
23 Assessment of a Knee Brace in Patients With Osteoarthritis Unknown status NCT02706106 Phase 4
24 Effectiveness of Trapeziometacarpal Splint Unknown status NCT02635932 Phase 4
25 26 Week Open Label Study Evaluating Single IA Injection of DUROLANE SJ for Treatment of Osteoarthritis Pain of the Ankle Unknown status NCT02627859 Phase 4
26 Effects of Hyaluronic Acid vs. Hyaluronic Acid on Knee Osteoarthritis Unknown status NCT02625727 Phase 4
27 Comparing Intra-articular Corticosteroid to Intra-articular Ketorolac Knee Injections Unknown status NCT02612272 Phase 4 Ketorolac;Betamethasone
28 Intravenous Iron Sucrose in Arthroplasty Unknown status NCT02544828 Phase 4 Iron Sucrose 200mg;placebo
29 The Post-marketing Surveillance to Evaluate the Efficacy of CHONDRON (Autologous Cultured Chondrocyte) by Arthroscopy Unknown status NCT02539069 Phase 4
30 The Post-marketing Surveillance to Evaluate the Efficacy and Safety of a CHONDRON (Autologous Cultured Chondrocyte) Unknown status NCT02539056 Phase 4
31 Multi-center Clinical Study of Guli Capsules in the Treatment of Knee Osteoarthritis Unknown status NCT02484508 Phase 4 Guli capsule;Kangguzengsheng capsule
32 Comparison of Topical and Infusion Tranexamic Acid After Total Knee Arthroplasty Unknown status NCT02453802 Phase 4 Tranexamic Acid 5%,5ml/amp;Tranexamic Acid 5%,5ml/amp;rivaroxaban (10mg);0.9% Normal Saline;0.9% Normal Saline
33 Validation of a Stress Device for the Knee Unknown status NCT02444663 Phase 4
34 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
35 Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE) Unknown status NCT02323451 Phase 4 Sodium Hyaluronate Injection
36 Tranexamic Acid in Knee Joint Surgery Unknown status NCT02278263 Phase 4 Tranexamic Acid;Normal saline (0.9% NaCl)
37 Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty Unknown status NCT02152917 Phase 4 Tranexamic acid;Floseal®
38 Intraarticular Xylitol Injections for Knee Osteoarthritis Unknown status NCT02104596 Phase 4
39 The Effect of Spironolactone on Pain in Older People With Osteoarthritis Unknown status NCT02046668 Phase 4 spironolactone
40 Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy Unknown status NCT02000297 Phase 4
41 A Phase 4 Study of Imrecoxib in Treatment of Knee Osteoarthritis Unknown status NCT01985165 Phase 4 Imrecoxib
42 Comparison of Femoral Nerve Catheter and Adductor Canal Block With Steroid Adjuvant in Total Knee Replacement (TKR) Unknown status NCT01973530 Phase 4
43 Keloid Scarring: Treatment and Pathophysiology Unknown status NCT01295099 Phase 4 5- fluorouracil;Triamcinolone
44 Reinflation After Early Tourniquet Release in Total Knee Arthroplasty Unknown status NCT01832272 Phase 4
45 Hip Viscosupplementation: What is the Best Dosage? Unknown status NCT01810809 Phase 4 1 ampoule of Hylan GF-20;2 ampoules of Hylan GF-20;3 ampoules of Hylan GF-20
46 Bone Forming at Prosthetic Surfaces. Fingerprint2 Unknown status NCT01623687 Phase 4
47 RSA Study Using Two Types of Uncemented Acetabular Components and the Uncemented HA Coated Symax Stem Unknown status NCT01618084 Phase 4
48 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
49 Chondroitin Sulphate Treatment Efficacy in Rhizarthrosis. Unknown status NCT01233739 Phase 4 Chondroitin sulfate;Placebo
50 Assessment of the Effects of Chondroitin Sulphate in Patients With Knee Osteoarthritis With Functional Magnetic Resonance Imaging (fMRI) Unknown status NCT01226615 Phase 4 Chondroitin sulphate (Condrosan®);Placebo

Search NIH Clinical Center for Collagen Disease

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: collagen diseases

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Genetic Tests for Collagen Disease

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Anatomical Context for Collagen Disease

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MalaCards organs/tissues related to Collagen Disease:

42
Bone, Testes, Eye, Bone Marrow, Heart, Brain, Skin
Sources

Publications for Collagen Disease

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Articles related to Collagen Disease:

(show top 50) (show all 480)
# Title Authors Year
1
Genetic identification of a common collagen disease in puerto ricans via identity-by-descent mapping in a health system. ( 28895531 )
2017
2
A scabies outbreak in a diabetic and collagen disease ward: Management and prevention. ( 28105102 )
2016
3
Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD. ( 26327779 )
2015
4
Serum biomarker analysis of collagen disease patients with acute-onset diffuse interstitial lung disease. ( 23405989 )
2013
5
Pulmonary manifestations of collagen diseases. ( 23683373 )
2013
6
Serum levels of tenascin-C in collagen diseases. ( 23834524 )
2013
7
Spontaneous rupture of autogenous saphenous vein graft in bypass surgery for peripheral arterial disease possibly associated with collagen disease. ( 22944580 )
2012
8
Left ventricular myocardial ischemia in collagen disease associated with pulmonary hypertension: an evaluation by rest-stress gated SPECT and coronary angiography. ( 21597395 )
2011
9
A polygene network model for the complex pathological phenotypes of collagen disease. ( 22029672 )
2011
10
Haemorrhoids - a collagen disease? ( 19614671 )
2010
11
Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease. ( 20307660 )
2010
12
Polygene network in collagen disease. ( 20453438 )
2010
13
Subcutaneous phaeohyphomycosis caused by Exophiala jeanselmei in collagen disease patient. ( 21083708 )
2010
14
Clinical features of liver dysfunction in collagen diseases. ( 20880057 )
2010
15
Myopia: a collagen disease? ( 19616386 )
2009
16
[Genetics of autoimmune and collagen diseases]. ( 19507500 )
2009
17
New aspect of anti-inflammatory action of lipo-prostaglandinE1 in the management of collagen diseases-related skin ulcer. ( 18461292 )
2008
18
Structural biology: Modelling collagen diseases. ( 18563144 )
2008
19
Unique microstructures and podocytic infolding in glomerular basement membrane associated with collagen diseases: a report of three cases. ( 18839060 )
2008
20
Is interstitial pneumonia in patients with collagen diseases a contraindication to lung cancer surgery? ( 17186339 )
2007
21
Cytokines in collagen disease-related atherogenesis. ( 17143992 )
2006
22
Serum levels of KL-6 are positively correlated with those of CA15-3 in patients with interstitial pneumonia associated with collagen diseases. ( 16771927 )
2006
23
Risk factors of abdominal surgery in patients with collagen diseases. ( 16986398 )
2006
24
Aluminum foil treatment combined with basic fibroblast growth factor (bFGF) for gangrene of the fingertip caused by collagen disease. ( 16320409 )
2005
25
Successful pregnancy outcome using sperm from severely diseased men with testicular cancer and collagen disease: Three case reports. ( 29657546 )
2004
26
Dystrophic breast calcifications in patients with collagen diseases. ( 14996440 )
2004
27
Post-transplantation chronic graft-versus-host disease with overlapping features similar to those of various collagen diseases. ( 12694496 )
2003
28
Gastrointestinal cytomegalovirus infection in collagen diseases. ( 12880302 )
2003
29
Gender differences in collagen diseases. ( 14673311 )
2003
30
Thoracic manifestations of the less common collagen diseases. A pictorial essay. ( 14735010 )
2003
31
[Clinical significance of cytokine and cytokine receptor analysis in collagen diseases]. ( 14621587 )
2003
32
Immunomodulation by the autonomic nervous system: therapeutic approach for cancer, collagen diseases, and inflammatory bowel diseases. ( 12423529 )
2002
33
[Contribution of Japanese researchers to progress in the study of allergy and collagen disease in the last 100 years: IL-6 and autoimmune diseases]. ( 12373879 )
2002
34
[Contribution of Japanese researchers to progress in the study of allergy and collagen disease in the last 100 years: Cytokines and cytokine receptors]. ( 12373883 )
2002
35
Tc-99m DTPA renography in patients with collagen disease. ( 11245107 )
2001
36
The occurrence of various collagen diseases in one family: a sister with ISSc, PBC, APS, and SS and a brother with systemic lupus erythematosus. ( 11732722 )
2001
37
Comparative evaluation of KL-6 and surfactant protein D as serum markers for interstitial pneumonia associated with collagen diseases. ( 24383687 )
2001
38
The liver in collagen diseases: pathologic study of 160 cases with particular reference to hepatic arteritis, primary biliary cirrhosis, autoimmune hepatitis and nodular regenerative hyperplasia of the liver. ( 11092254 )
2000
39
Genome analysis of collagen disease in MRL/lpr mice: polygenic inheritance resulting in the complex pathological manifestations. ( 10980337 )
2000
40
Genome analysis of collagen disease in MRL/lpr mice: polygenic inheritance resulting in the complex pathological manifestations ( 10980338 )
2000
41
Genetic basis of the complex pathological manifestations of collagen disease: lessons from MRL/lpr and related mouse models. ( 11016428 )
2000
42
Thallium-201 myocardial SPET in patients with collagen disease. ( 11039455 )
2000
43
Clinical significance of ventilation/perfusion scans in collagen disease patients. ( 11210092 )
2000
44
Collagen diseases in children. ( 11173207 )
2000
45
Diagnosis and treatment of pulmonary hypertension associated with collagen diseases. ( 10801140 )
2000
46
KL-6 as a novel serum marker for interstitial pneumonia associated with collagen diseases. ( 10813282 )
2000
47
Immunoglobulin isotypes of anti-myeloperoxidase and anti-lactoferrin antibodies in patients with collagen diseases. ( 10939715 )
2000
48
Effects of nilvadipine on cytokine-levels and soluble factors in collagen disease complicated with essential hypertension. ( 10513835 )
1999
49
Genetic dissection of the complex pathological manifestations of collagen disease in MRL/lpr mice. ( 10594844 )
1999
50
Prevalence of normal-tension glaucoma and primary open-angle glaucoma in patients with collagen diseases. ( 10672886 )
1999
Sources

Variations for Collagen Disease

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Expression for Collagen Disease

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Search GEO for disease gene expression data for Collagen Disease.
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Pathways for Collagen Disease

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Pathways related to Collagen Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Focal Adhesion 1 38
Show member pathways
 12.6 COL1A2 COL3A1 COL5A1 COL5A2 TNXB
2
Collagen chain trimerization 67
Show member pathways
 12.38 COL1A2 COL3A1 COL5A1 COL5A2 PLOD1
3
Degradation of the extracellular matrix 67
Show member pathways
 12.09 COL1A2 COL3A1 COL5A1 COL5A2 PLOD1 TNXB
4
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 11.87 CCR6 COL1A2 COL3A1 COL5A1 COL5A2
5
AGE-RAGE signaling pathway in diabetic complications 38
11.58 COL1A2 COL3A1 EDN1
6
Endothelins 1
11.06 COL1A2 COL3A1 EDN1
7
miRNA targets in ECM and membrane receptors 1
10.65 COL1A2 COL3A1 COL5A1 COL5A2 TNXB
8
G-protein signaling_Rap2B regulation pathway 23
10.62 CCN2 COL1A2 COL3A1 COL5A1 COL5A2
Sources

GO Terms for Collagen Disease

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Cellular components related to Collagen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.62 COL1A2 COL3A1 COL5A1 COL5A2
2 collagen-containing extracellular matrix GO:0062023 9.55 COL1A2 COL3A1 COL5A1 COL5A2 TNXB
3 collagen type V trimer GO:0005588 9.26 COL5A1 COL5A2
4 collagen trimer GO:0005581 9.26 COL1A2 COL3A1 COL5A1 COL5A2
5 extracellular matrix GO:0031012 9.1 CCN2 COL1A2 COL3A1 COL5A1 COL5A2 TNXB

Biological processes related to Collagen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.67 COL1A2 COL3A1 COL5A2 EDN1
2 cellular response to amino acid stimulus GO:0071230 9.63 COL1A2 COL3A1 COL5A2
3 blood vessel development GO:0001568 9.61 COL1A2 COL3A1 COL5A1
4 skin development GO:0043588 9.58 COL3A1 COL5A1 COL5A2
5 extracellular matrix organization GO:0030198 9.55 COL1A2 COL3A1 COL5A1 COL5A2 TNXB
6 collagen metabolic process GO:0032963 9.48 PLOD1 TNXB
7 eye morphogenesis GO:0048592 9.32 COL5A1 COL5A2
8 negative regulation of endodermal cell differentiation GO:1903225 9.26 COL5A1 COL5A2
9 supramolecular fiber organization GO:0097435 9.13 B4GALT7 COL3A1 COL5A1
10 collagen fibril organization GO:0030199 9.1 COL1A2 COL3A1 COL5A1 COL5A2 PLOD1 TNXB

Molecular functions related to Collagen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.56 CCN2 COL3A1 COL5A1 TNXB
2 SMAD binding GO:0046332 9.5 COL1A2 COL3A1 COL5A2
3 extracellular matrix structural constituent GO:0005201 9.35 COL1A2 COL3A1 COL5A1 COL5A2 TNXB
4 platelet-derived growth factor binding GO:0048407 9.33 COL1A2 COL3A1 COL5A1
5 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.92 COL1A2 COL3A1 COL5A1 COL5A2
6 protein binding GO:0005515 10.27 B4GALT7 CCN2 CCR6 COL1A2 COL3A1 COL5A1
Sources

Sources for Collagen Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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