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MCID: CLL015
MIFTS: 52

Collagen Disease

Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Collagen Disease

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MalaCards integrated aliases for Collagen Disease:

Name: Collagen Disease 12 15
Collagen Diseases 55 44 73
Collagen Disorder 12 76

External Ids:

Disease Ontology 12 DOID:854
MeSH 44 D003095
NCIt 50 C27204
UMLS 73 C0009326
Sources

Summaries for Collagen Disease

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MalaCards based summary : Collagen Disease, also known as collagen diseases, is related to rheumatic disease and ehlers-danlos syndrome. An important gene associated with Collagen Disease is COL1A1 (Collagen Type I Alpha 1 Chain), and among its related pathways/superpathways are Integrin Pathway and Phospholipase-C Pathway. The drugs Parecoxib and Naproxen have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and eye, and related phenotypes are cardiovascular system and mortality/aging

Wikipedia : 76 A connective tissue disease is any disease that has the connective tissues of the body as a target of... more...

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Related Diseases for Collagen Disease

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Diseases in the Collagen Disease family:

Collagen Type Vi-Related Disorders

Diseases related to Collagen Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 rheumatic disease 32.0 APOH CENPB TOP1
2 ehlers-danlos syndrome 31.2 COL1A1 COL1A2 COL3A1 COL5A1 COL5A2
3 vasculitis 30.1 APOH THBD VWF
4 vascular disease 29.7 APOH ELN THBD VWF
5 scleroderma, familial progressive 29.7 COL1A1 COL1A2 CTGF TOP1
6 systemic lupus erythematosus 29.6 APOH RPL7 SNRNP70 THBD TLR9 VWF
7 connective tissue disease 26.7 APOH CENPB COL1A1 COL1A2 COL3A1 COL5A1
8 disseminated eosinophilic collagen disease 12.1
9 alpha-2-deficient collagen disease 11.9
10 unilateral absence of a pulmonary artery 11.0 THBD VWF
11 ehlers-danlos/osteogenesis imperfecta syndrome 10.9 COL1A1 COL1A2
12 plica syndrome 10.9 ELN VWF
13 hypereosinophilic syndrome 10.9
14 familial abdominal aortic aneurysm 10.9 COL3A1 ELN
15 ehlers-danlos syndrome, hypermobility type 10.9 COL1A1 COL3A1
16 high bone mass osteogenesis imperfecta 10.8 COL1A1 COL1A2
17 pilomyxoid astrocytoma 10.8 COL1A1 COL2A1
18 osteogenesis imperfecta, type viii 10.8 COL1A1 COL1A2
19 raynaud phenomenon 10.8 APOH THBD VWF
20 thrombophilia due to activated protein c resistance 10.8 APOH THBD VWF
21 thrombotic thrombocytopenic purpura 10.8 APOH THBD VWF
22 thrombophilia due to thrombin defect 10.8 APOH THBD VWF
23 pelvic organ prolapse 10.7 COL1A1 COL3A1 ELN
24 osteogenesis imperfecta, type vii 10.7 COL1A1 COL1A2
25 purpura 10.7 APOH THBD VWF
26 tympanosclerosis 10.7 COL1A1 COL2A1
27 ehlers-danlos syndrome, classic type, 2 10.7 COL1A1 COL5A1 COL5A2
28 thrombosis 10.7 APOH THBD VWF
29 ehlers-danlos syndrome, vascular type 10.7 COL3A1 COL5A1 ELN
30 hellp syndrome 10.7 APOH THBD VWF
31 mixed connective tissue disease 10.7
32 raynaud disease 10.7 TOP1 VWF
33 bone fragility with contractures, arterial rupture, and deafness 10.7
34 collagenopathy, types ii and xi 10.7
35 bone development disease 10.7 COL1A1 COL1A2 COL2A1
36 varicose veins 10.6 COL3A1 ELN VWF
37 hypermobility syndrome 10.6 COL3A1 COL5A1 COL5A2
38 pfeiffer syndrome 10.6 COL1A1 COL3A1 TLR9
39 lipoblastoma 10.6 COL1A2 COL3A1
40 intracranial aneurysm 10.6 COL1A2 COL3A1 ELN
41 crest syndrome 10.5 CENPB TOP1
42 idiopathic interstitial pneumonia 10.5 CTGF SFTPD TLR9
43 spondyloepiphyseal dysplasia congenita 10.5 COL1A1 COL1A2 COL2A1 COL3A1
44 brittle bone disorder 10.5 COL1A1 COL1A2 COL2A1 COL3A1
45 larsen-like syndrome 10.4 COL1A1 COL1A2 COL3A1 COL5A2
46 dyskinesia of esophagus 10.4 CENPB TOP1
47 immune system disease 10.4 APOH SCHIP1 TLR9 VWF
48 ehlers-danlos syndrome, classic type 10.4 COL1A1 COL1A2 COL5A1 COL5A2
49 marfan syndrome 10.3 COL1A2 COL3A1 COL5A2 ELN
50 childhood type dermatomyositis 10.3 EXOSC10 VWF

Graphical network of the top 20 diseases related to Collagen Disease:



Diseases related to Collagen Disease
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Symptoms & Phenotypes for Collagen Disease

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MGI Mouse Phenotypes related to Collagen Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.07 VWF COL2A1 COL3A1 THBD COL5A1 COL5A2
2 mortality/aging MP:0010768 10.03 TOP1 VWF SFTPD THBD COL3A1 COL5A1
3 growth/size/body region MP:0005378 10 SFTPD COL2A1 COL3A1 THBD COL5A1 CENPB
4 digestive/alimentary MP:0005381 9.92 VWF THBD COL3A1 TLR9 COL1A1 CTGF
5 normal MP:0002873 9.61 COL2A1 THBD COL5A1 COL5A2 CENPB COL1A1
6 respiratory system MP:0005388 9.17 SFTPD COL2A1 COL3A1 THBD COL5A2 COL1A1
Sources

Drugs & Therapeutics for Collagen Disease

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Drugs for Collagen Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 923)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Parecoxib Approved Phase 4,Phase 3,Not Applicable 198470-84-7
2
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22204-53-1 1302 156391
3
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
4
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
5
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 174722-31-7 10201696
6
Hydroxychloroquine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 118-42-3 3652
7
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 9004-61-9 53477741
8
Menthol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2216-51-5 16666
9
Abatacept Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 332348-12-6 10237
10
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 170277-31-3
11
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 169590-42-5 2662
12
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 202409-33-4 123619
13
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 2180-92-9, 38396-39-3 2474
14
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 772 46507594
15
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 161796-78-7, 119141-88-7 4594 9579578
16
Iron Approved Phase 4,Phase 3,Phase 1,Phase 2 7439-89-6 23925
17
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-61-6, 62-31-7 681
18
Meloxicam Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 71125-38-7 5281106 54677470
19
Ketorolac Approved Phase 4,Phase 3,Phase 2,Not Applicable 74103-06-3, 66635-83-4 3826
20
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-84-3 187
21
Ephedrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 299-42-3 9294
22
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 90-82-4 7028
23
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1959-05-2, 59-05-2 126941
24
Sulfasalazine Approved Phase 4,Phase 3,Phase 2,Not Applicable 599-79-1 5353980 5359476
25
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 27203-92-5 33741
26
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-41-2 439260
27
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-78-2 2244
28
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 15307-86-5 3033
29
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
30
Amitriptyline Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-48-6 2160
31
Morphine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 57-27-2 5288826
32
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1197-18-8 5526
33
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 148553-50-8 5486971
34
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
35
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
36
Chromium Approved Phase 4,Phase 3,Phase 2,Not Applicable 7440-47-3 27668
37
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3 113775-47-6 68602 5311068
38
Calcium Carbonate Approved, Investigational Phase 4,Phase 3,Phase 2 471-34-1
39
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 185243-69-0
40
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 124-94-7 31307
41
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 76-42-6 5284603
42
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-24-8 5755
43
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 103-90-2 1983
44
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Not Applicable 84057-95-4 71273 175805
45
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15687-27-1 3672
46
Cimetidine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 51481-61-9 2756
47
Tacrolimus Approved, Investigational Phase 4,Phase 3,Early Phase 1 104987-11-3 445643 439492
48
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 428863-50-7
49
Leflunomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 75706-12-6 3899
50
Milnacipran Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 92623-85-3 65833

Interventional clinical trials:

(show top 50) (show all 6157)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
2 Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis Unknown status NCT02087696 Phase 4 Tocilizumab
3 Vaccination Against Pertussis, Tetanus and Diphtheria in Patients Suffering From Rheumatoid Arthritis Unknown status NCT01301703 Phase 4
4 Efficacy Study of Leflunomide to Treat Juvenile Idiopathic Arthritis Unknown status NCT02024334 Phase 4 Leflunomide
5 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
6 TNF-blocking Therapy in Combination With Disease-modifying Antirheumatic Drugs in Early Rheumatoid Arthritis Unknown status NCT00908089 Phase 4 Trexan+Salazopyrin+Oxiklorin+prednisolone + infliximab;Trexan+Salazopyrin+Oxiklorin+prednisolone + placebo
7 Obesity Cohort : Medical Follow-up of Severe or Morbid Obese Patients Undergoing Bariatric Surgery Unknown status NCT02310178 Phase 4
8 Very Early Versus Delayed Etanercept in Patients With RA Unknown status NCT02433184 Phase 4 Etanercept;Methotrexate;Sulfasalazine;Hydroxychloroquine;Etanercept;Methotrexate
9 Pilot Study to Evaluate Clinical Outcomes With the Use of Biovance Following Keloid Scar Revision Surgery Unknown status NCT02521402 Phase 4
10 Influence of Perception of Patients Suffering of Knee Osteoarthritis Regarding Effectiveness of Intra-articular Injection Unknown status NCT02835521 Phase 4 Joint injection with triamcinolone hexacetonide
11 Safety and Efficacy of Intra-articular Ozone Injections for Knee Osteoarthritis Unknown status NCT02833545 Phase 4
12 Intra-articular Botox Type A Versus Corticosteroids in Knee Osteoarthritis Unknown status NCT02829281 Phase 4 Botulinum Toxin Type A;Triamcinolone hexacetonide;Saline
13 Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN Unknown status NCT02821468 Phase 4 Droglican;Paracetamol or oral NSAIDs excluding COX2 inhibitors
14 Assessment of a Knee Brace in Patients With Osteoarthritis Unknown status NCT02706106 Phase 4
15 Effectiveness of Trapeziometacarpal Splint Unknown status NCT02635932 Phase 4
16 Effects of Hyaluronic Acid vs. Hyaluronic Acid on Knee Osteoarthritis Unknown status NCT02625727 Phase 4
17 Intravenous Iron Sucrose in Arthroplasty Unknown status NCT02544828 Phase 4 Iron Sucrose 200mg;placebo
18 Does Intraoperative Intravenous Iron Enhance Postoperative Oxygenation Profile in Total Knee Arthroplasty Surgery? Unknown status NCT02544464 Phase 4 ferric carboxymaltose 1000 mg;placebo
19 The Post-marketing Surveillance to Evaluate the Efficacy of CHONDRON (Autologous Cultured Chondrocyte) by Arthroscopy Unknown status NCT02539069 Phase 4
20 The Post-marketing Surveillance to Evaluate the Efficacy and Safety of a CHONDRON (Autologous Cultured Chondrocyte) Unknown status NCT02539056 Phase 4
21 Multi-center Clinical Study of Guli Capsules in the Treatment of Knee Osteoarthritis Unknown status NCT02484508 Phase 4 Guli capsule;Kangguzengsheng capsule
22 Comparison of Topical and Infusion Tranexamic Acid After Total Knee Arthroplasty Unknown status NCT02453802 Phase 4 Tranexamic Acid 5%,5ml/amp;Tranexamic Acid 5%,5ml/amp;rivaroxaban (10mg);0.9% Normal Saline;0.9% Normal Saline
23 Validation of a Stress Device for the Knee Unknown status NCT02444663 Phase 4
24 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
25 Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE) Unknown status NCT02323451 Phase 4 Sodium Hyaluronate Injection
26 Tranexamic Acid in Knee Joint Surgery Unknown status NCT02278263 Phase 4 Tranexamic Acid;Normal saline (0.9% NaCl)
27 Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty Unknown status NCT02152917 Phase 4 Tranexamic acid;Floseal®
28 Intraarticular Xylitol Injections for Knee Osteoarthritis Unknown status NCT02104596 Phase 4
29 Daily Activity and Gait Analysis After Viscosupplement Injection Among Hip Osteoarthritis Patients Unknown status NCT02086474 Phase 4 Hyaluronan;Bupivacaine
30 The Effect of Spironolactone on Pain in Older People With Osteoarthritis Unknown status NCT02046668 Phase 4 spironolactone
31 Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy Unknown status NCT02000297 Phase 4
32 A Phase 4 Study of Imrecoxib in Treatment of Knee Osteoarthritis Unknown status NCT01985165 Phase 4 Imrecoxib
33 Comparison of Femoral Nerve Catheter and Adductor Canal Block With Steroid Adjuvant in Total Knee Replacement (TKR) Unknown status NCT01973530 Phase 4
34 Keloid Scarring: Treatment and Pathophysiology Unknown status NCT01295099 Phase 4 5- fluorouracil;Triamcinolone
35 Reinflation After Early Tourniquet Release in Total Knee Arthroplasty Unknown status NCT01832272 Phase 4
36 Hip Viscosupplementation: What is the Best Dosage? Unknown status NCT01810809 Phase 4 1 ampoule of Hylan GF-20;2 ampoules of Hylan GF-20;3 ampoules of Hylan GF-20
37 Bone Forming at Prosthetic Surfaces. Fingerprint2 Unknown status NCT01623687 Phase 4
38 RSA Study Using Two Types of Uncemented Acetabular Components and the Uncemented HA Coated Symax Stem Unknown status NCT01618084 Phase 4
39 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
40 Chondroitin Sulphate Treatment Efficacy in Rhizarthrosis. Unknown status NCT01233739 Phase 4 Chondroitin sulfate;Placebo
41 Assessment of the Effects of Chondroitin Sulphate in Patients With Knee Osteoarthritis With Functional Magnetic Resonance Imaging (fMRI) Unknown status NCT01226615 Phase 4 Chondroitin sulphate (Condrosan®);Placebo
42 Prophecy Guide Outcomes in Total Knee Replacement Surgery Unknown status NCT01163708 Phase 4
43 Comparison of Outcomes in Mobile and Fixed-bearing Total Knee Arthroplasty Unknown status NCT01027819 Phase 4
44 A Randomized Clinical Study Comparing Two Closure Techniques of Excised Keloids Unknown status NCT00519493 Phase 4
45 The Impact of Hyaluronic Acid Injections on Osteoarthritic Knee Mechanics Unknown status NCT00778076 Phase 4
46 Use of Cold and Compression Therapy With Total Knee Replacement Patients Unknown status NCT00712816 Phase 4
47 Trial Comparing Navigated and Conventional Implantation Techniques in Knee Replacement Surgery Unknown status NCT00431509 Phase 4
48 The Effect of Intraaricular Knee Injections of Hyaluronic Acid (HA) on Bone and Cartilaginous Debris, as a Therapeutic Indicator Unknown status NCT00422643 Phase 4 Sodium hyaluronate (hyaluronic acid)
49 Effectiveness Study of Hylan G-F 20 to Preserve Cartilage in Osteoarthritis of the Knee Unknown status NCT00393393 Phase 4 intra-articular injection of Hylan G-F 20
50 Effect of Flex-a-New on Osteoarthritis of the Knee Unknown status NCT00294801 Phase 4 flex-a-new (food supplement)

Search NIH Clinical Center for Collagen Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: collagen diseases

Sources

Genetic Tests for Collagen Disease

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Anatomical Context for Collagen Disease

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MalaCards organs/tissues related to Collagen Disease:

41
Bone, Testes, Eye, Bone Marrow, Heart, Skin, Brain
Sources

Publications for Collagen Disease

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Articles related to Collagen Disease:

(show top 50) (show all 201)
# Title Authors Year
1
Genetic identification of a common collagen disease in puerto ricans via identity-by-descent mapping in a health system. ( 28895531 )
2017
2
A scabies outbreak in a diabetic and collagen disease ward: Management and prevention. ( 28105102 )
2016
3
Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD. ( 26327779 )
2015
4
Serum levels of tenascin-C in collagen diseases. ( 23834524 )
2013
5
Serum biomarker analysis of collagen disease patients with acute-onset diffuse interstitial lung disease. ( 23405989 )
2013
6
Spontaneous rupture of autogenous saphenous vein graft in bypass surgery for peripheral arterial disease possibly associated with collagen disease. ( 22944580 )
2012
7
A polygene network model for the complex pathological phenotypes of collagen disease. ( 22029672 )
2011
8
Left ventricular myocardial ischemia in collagen disease associated with pulmonary hypertension: an evaluation by rest-stress gated SPECT and coronary angiography. ( 21597395 )
2011
9
Polygene network in collagen disease. ( 20453438 )
2010
10
Subcutaneous phaeohyphomycosis caused by Exophiala jeanselmei in collagen disease patient. ( 21083708 )
2010
11
Haemorrhoids - a collagen disease? ( 19614671 )
2010
12
Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease. ( 20307660 )
2010
13
[Genetics of autoimmune and collagen diseases]. ( 19507500 )
2009
14
Myopia: a collagen disease? ( 19616386 )
2009
15
New aspect of anti-inflammatory action of lipo-prostaglandinE1 in the management of collagen diseases-related skin ulcer. ( 18461292 )
2008
16
Cytokines in collagen disease-related atherogenesis. ( 17143992 )
2006
17
Aluminum foil treatment combined with basic fibroblast growth factor (bFGF) for gangrene of the fingertip caused by collagen disease. ( 16320409 )
2005
18
Successful pregnancy outcome using sperm from severely diseased men with testicular cancer and collagen disease: Three case reports. ( 29657546 )
2004
19
[Clinical significance of cytokine and cytokine receptor analysis in collagen diseases]. ( 14621587 )
2003
20
[Contribution of Japanese researchers to progress in the study of allergy and collagen disease in the last 100 years: Cytokines and cytokine receptors]. ( 12373883 )
2002
21
[Contribution of Japanese researchers to progress in the study of allergy and collagen disease in the last 100 years: IL-6 and autoimmune diseases]. ( 12373879 )
2002
22
Tc-99m DTPA renography in patients with collagen disease. ( 11245107 )
2001
23
Thallium-201 myocardial SPET in patients with collagen disease. ( 11039455 )
2000
24
Genome analysis of collagen disease in MRL/lpr mice: polygenic inheritance resulting in the complex pathological manifestations. ( 10980337 )
2000
25
Genome analysis of collagen disease in MRL/lpr mice: polygenic inheritance resulting in the complex pathological manifestations ( 10980338 )
2000
26
The liver in collagen diseases: pathologic study of 160 cases with particular reference to hepatic arteritis, primary biliary cirrhosis, autoimmune hepatitis and nodular regenerative hyperplasia of the liver. ( 11092254 )
2000
27
Clinical significance of ventilation/perfusion scans in collagen disease patients. ( 11210092 )
2000
28
Genetic basis of the complex pathological manifestations of collagen disease: lessons from MRL/lpr and related mouse models. ( 11016428 )
2000
29
Genetic dissection of the complex pathological manifestations of collagen disease in MRL/lpr mice. ( 10594844 )
1999
30
[Clinical evaluation of serum cytokine from patients with collagen diseases]. ( 10340006 )
1999
31
Effects of nilvadipine on cytokine-levels and soluble factors in collagen disease complicated with essential hypertension. ( 10513835 )
1999
32
Serum concentrations of vascular endothelial growth factor in collagen diseases. ( 9990370 )
1998
33
Collagen disease: the enemy within. ( 9863615 )
1998
34
Alport syndrome: clinical and genetic correlation in a type-IV collagen disease. ( 9399052 )
1997
35
Leishmaniasis mimicking collagen disease. ( 9251665 )
1997
36
Retropharyngeal abscess after radiation therapy and cis-platinum, 5-fluorouracil treatment for nasopharyngeal carcinoma with collagen disease: report of two patients and a review of the literature. ( 8656563 )
1996
37
Unusual systemic lupus erythematosus-like reaction to minocycline in a patient with acne and antecedent collagen disease. ( 19078088 )
1996
38
[Studies of serum markers in patients with interstitial pneumonia/pulmonary fibrosis complicated with collagen diseases: clinical evaluation of CYFRA21-1]. ( 9122823 )
1996
39
[Detection of anti small nuclear ribonucleoprotein antibody in patients with collagen disease--a comparison of sensitivities of four methods]. ( 7570209 )
1995
40
Severe reaction after chemoradiotherapy of nasopharyngeal carcinoma with collagen disease. ( 7591915 )
1995
41
Study of interleukin-2 receptor in schistosomiasis mansoni and its analogous changes in collagen diseases and schistosomal arthropathy. ( 7665927 )
1995
42
Immunological changes in hydroxyurea-induced collagen disease. ( 7947215 )
1994
43
[Ribosomal protein L7 as an autoantigen in patients with systemic lupus erythematosus, mixed collagen disease and rheumatoid arthritis]. ( 7856252 )
1994
44
Glycosaminoglycan-collagen interactions in vitro in the hydralazine-induced collagen disease-like syndrome. ( 8372554 )
1993
45
[OKT4 epitope deficiency in collagen disease patients]. ( 7684165 )
1993
46
Addition of serum from patients with collagen diseases increases to cultured human endothelial cells production and release of von Willebrand factor. ( 8438904 )
1993
47
[Distribution of cofactor-dependent anti-cardiolipin antibodies in collagen diseases]. ( 8360993 )
1993
48
Clinical significance of anti-neutrophil cytoplasmic antibodies (ANCA) in collagen diseases associated with vasculitic syndrome in Japan. ( 1635282 )
1992
49
Plasma coagulation and fibrinolysis parameters in patients with collagen diseases, and analysis of the multimeric structure of von Willebrand factor (vWF). ( 1756253 )
1991
50
Protein losing enteropathy associated with collagen diseases. ( 2015012 )
1991
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Variations for Collagen Disease

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Expression for Collagen Disease

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Search GEO for disease gene expression data for Collagen Disease.
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Pathways for Collagen Disease

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Pathways related to Collagen Disease according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Integrin Pathway 64
Show member pathways
 13.22 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
2
Phospholipase-C Pathway 64
Show member pathways
 12.75 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
3
Focal Adhesion 37 1
Show member pathways
 12.72 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
4
Degradation of the extracellular matrix 66
Show member pathways
 12.15 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
5
ECM-receptor interaction 37
Show member pathways
 11.97 COL1A1 COL1A2 COL2A1 VWF
6
Collagen chain trimerization 66
Show member pathways
 11.95 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
7
Platelet activation 37
11.87 COL1A1 COL1A2 COL3A1 VWF
8
AGE-RAGE signaling pathway in diabetic complications 37
11.73 COL1A1 COL1A2 COL3A1 THBD
9
Binding and Uptake of Ligands by Scavenger Receptors 66
Show member pathways
 11.72 COL1A1 COL1A2 COL3A1
10
Amoebiasis 37
11.67 COL1A1 COL1A2 COL3A1
11
Cell adhesion_ECM remodeling 22
11.45 COL1A1 COL1A2 COL2A1 COL3A1
12
Platelet Aggregation Inhibitor Pathway, Pharmacodynamics 61
11.33 COL1A1 COL1A2 COL3A1 VWF
13
Inflammatory Response Pathway 1
11.15 COL1A1 COL1A2 COL3A1
14
miRNA targets in ECM and membrane receptors 1
11.09 COL1A2 COL3A1 COL5A1 COL5A2
Sources

GO Terms for Collagen Disease

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Cellular components related to Collagen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.9 APOH COL1A1 COL1A2 COL2A1 COL3A1 COL5A1
2 endoplasmic reticulum lumen GO:0005788 9.8 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
3 collagen trimer GO:0005581 9.5 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
4 collagen type V trimer GO:0005588 9.4 COL5A1 COL5A2
5 collagen type I trimer GO:0005584 9.37 COL1A1 COL1A2
6 extracellular matrix GO:0031012 9.28 APOH COL1A1 COL1A2 COL2A1 COL3A1 COL5A1
7 extracellular region GO:0005576 10.03 APOH COL1A1 COL1A2 COL2A1 COL3A1 COL5A1

Biological processes related to Collagen Disease according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.84 COL1A1 COL1A2 THBD VWF
2 regulation of immune response GO:0050776 9.83 COL1A1 COL1A2 COL2A1 COL3A1 SFTPD
3 platelet activation GO:0030168 9.8 COL1A1 COL1A2 COL3A1 VWF
4 skeletal system development GO:0001501 9.77 COL1A1 COL1A2 COL2A1 COL3A1 COL5A2
5 ossification GO:0001503 9.76 COL1A1 COL2A1 COL5A2 CTGF
6 blood vessel development GO:0001568 9.71 COL1A1 COL1A2 COL3A1 COL5A1
7 collagen catabolic process GO:0030574 9.63 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2
8 cellular response to amino acid stimulus GO:0071230 9.62 COL1A1 COL1A2 COL3A1 COL5A2
9 cartilage condensation GO:0001502 9.61 COL2A1 CTGF
10 tissue homeostasis GO:0001894 9.61 COL2A1 CTGF
11 blood coagulation, intrinsic pathway GO:0007597 9.6 APOH VWF
12 negative regulation of blood coagulation GO:0030195 9.59