MCID: CLL015
MIFTS: 47

Collagen Disease

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Collagen Disease

MalaCards integrated aliases for Collagen Disease:

Name: Collagen Disease 12 15
Collagen Diseases 54 44 70
Collagen Disorder 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:854
MeSH 44 D003095
NCIt 50 C27204
SNOMED-CT 67 268048008
UMLS 70 C0009326

Summaries for Collagen Disease

Disease Ontology : 12 A connective tissue disease that characterized by connective tissue disease that has material basis in inheritable defects in collagen.

MalaCards based summary : Collagen Disease, also known as collagen diseases, is related to ehlers-danlos syndrome and vasculitis. An important gene associated with Collagen Disease is PLOD1 (Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 1), and among its related pathways/superpathways are Integrin Pathway and Phospholipase-C Pathway. The drugs Acetaminophen and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and eye, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 73 A connective tissue disease (collagenosis) is any disease that has the connective tissues of the body as... more...

Related Diseases for Collagen Disease

Diseases in the Collagen Disease family:

Type Ii Collagen Disorders

Diseases related to Collagen Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 366)
# Related Disease Score Top Affiliating Genes
1 ehlers-danlos syndrome 30.9 TNXB SLC39A13 PLOD1 ELN COL5A2 COL5A1
2 vasculitis 30.8 VWF THBD SERPINA3 APOH
3 antiphospholipid syndrome 30.4 VWF THBD APOH
4 purpura 30.4 VWF THBD APOH
5 thrombotic microangiopathy 30.4 VWF THBD
6 respiratory failure 30.1 THBD SFTPD SERPINA3 NPPA
7 aortic valve insufficiency 30.1 VWF NPPA ELN
8 thrombotic thrombocytopenic purpura 30.0 VWF THBD APOH
9 spondyloepiphyseal dysplasia with congenital joint dislocations 30.0 COL2A1 CHST14 B4GALT7
10 glaucoma, primary open angle 30.0 SERPINA3 ELN COL5A1
11 diffuse scleroderma 30.0 SNRNP70 COL1A1
12 blood coagulation disease 29.9 VWF THBD SERPINA3 APOH
13 pulmonary fibrosis, idiopathic 29.9 THBD SFTPD ELN COL3A1 COL1A1
14 orthostatic intolerance 29.9 PLOD1 ELN COL5A2 COL5A1 COL3A1
15 connective tissue disease 29.8 TNXB SNRNP70 SFTPD SERPINA3 PLOD1 ELN
16 marfan syndrome 29.8 ELN COL5A2 COL5A1 COL3A1 COL2A1 COL1A1
17 osteochondrodysplasia 29.4 PLOD1 ELN COL5A2 COL5A1 COL3A1 COL2A1
18 brittle bone disorder 29.4 TNXB PLOD1 ELN COL5A2 COL5A1 COL3A1
19 disseminated eosinophilic collagen disease 11.3
20 alpha-2-deficient collagen disease 11.2
21 pierre robin syndrome associated with collagen disease 11.2
22 hypereosinophilic syndrome 11.1
23 mixed connective tissue disease 10.9
24 temporal arteritis 10.9
25 unilateral absence of a pulmonary artery 10.5 VWF THBD
26 familial abdominal aortic aneurysm 10.4 ELN COL3A1
27 developmental dysplasia of the hip 1 10.4 COL5A1 COL2A1
28 discrete subaortic stenosis 10.4 NPPA ELN
29 eisenmenger syndrome 10.4 VWF THBD
30 aneurysm 10.4 PLOD1 ELN COL3A1
31 platelet aggregation, spontaneous 10.4 VWF SERPINA3
32 thrombophilia 10.4 VWF THBD APOH
33 plantar fascial fibromatosis 10.4 COL3A1 COL1A1
34 legg-calve-perthes disease 10.4 THBD COL2A1 APOH
35 ureteric orifice cancer 10.4 TNXB ELN
36 tibialis tendinitis 10.4 TNXB COL5A2
37 thyroid angiosarcoma 10.4 VWF THBD
38 malignant hypertension 10.4 VWF THBD NPPA
39 synovial chondromatosis 10.4 COL2A1 COL1A1
40 thrombophilia due to activated protein c resistance 10.4 VWF THBD APOH
41 mitral valve stenosis 10.4 VWF SERPINA3 NPPA
42 epicondylitis 10.4 COL5A1 COL1A1
43 syndromic x-linked intellectual disability cabezas type 10.4 SNRNP70 SERPINA3 COL1A1
44 ehlers-danlos syndrome, vascular type 10.4 ELN COL5A1 COL3A1
45 caspase 8 deficiency 10.4 PLOD1 COL5A2 COL5A1
46 hypomelanosis of ito 10.4 PLOD1 COL5A1
47 autoimmune disease of cardiovascular system 10.4 VWF SERPINA3 APOH
48 mitral valve disease 10.4 SERPINA3 NPPA ELN
49 tricuspid valve prolapse 10.4 COL3A1 CHST14
50 ehlers-danlos syndrome, classic type, 2 10.4 COL5A2 COL5A1 COL3A1

Graphical network of the top 20 diseases related to Collagen Disease:



Diseases related to Collagen Disease

Symptoms & Phenotypes for Collagen Disease

GenomeRNAi Phenotypes related to Collagen Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 10.02 RPL7
2 Decreased viability GR00221-A-1 10.02 COL3A1
3 Decreased viability GR00221-A-2 10.02 COL3A1
4 Decreased viability GR00221-A-4 10.02 COL3A1
5 Decreased viability GR00240-S-1 10.02 RPL7
6 Decreased viability GR00249-S 10.02 CHST14 NPPA PLOD1 RPL7 SERPINA3
7 Decreased viability GR00381-A-1 10.02 PLOD1 RPL7 SLC39A13
8 Decreased viability GR00386-A-1 10.02 B4GALT7 CHST14 ELN PLOD1 RPL7
9 Decreased viability GR00402-S-2 10.02 ELN NPPA RPL7 SNRNP70 TNXB
10 Increased the percentage of infected cells GR00402-S-1 8.32 COL27A1

MGI Mouse Phenotypes related to Collagen Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 CHST14 COL1A1 COL27A1 COL2A1 COL3A1 COL5A1
2 integument MP:0010771 9.85 CHST14 COL1A1 COL3A1 COL5A1 COL5A2 PLOD1
3 mortality/aging MP:0010768 9.77 APOH CHST14 COL1A1 COL27A1 COL2A1 COL3A1
4 respiratory system MP:0005388 9.17 COL1A1 COL27A1 COL2A1 COL3A1 COL5A2 SFTPD

Drugs & Therapeutics for Collagen Disease

Drugs for Collagen Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 126)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
3
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
4
Lactitol Approved, Investigational Phase 4 585-86-4 157355
5
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
6
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
7
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
8
Abatacept Approved Phase 4 332348-12-6 10237
9
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
10 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
11 Analgesics Phase 4
12 Analgesics, Non-Narcotic Phase 4
13 Antipyretics Phase 4
14 Hydrocortisone 17-butyrate 21-propionate Phase 4
15 Hydrocortisone hemisuccinate Phase 4
16 Gentamicins Phase 4
17 Sodium Chloride Symporter Inhibitors Phase 4
18 diuretics Phase 4
19 Immunoglobulins Phase 4
20 Antibodies Phase 4
21 Folic Acid Antagonists Phase 4
22 Vitamin B9 Phase 4
23 Vitamin B Complex Phase 4
24 Folate Phase 4
25 Antimetabolites Phase 4
26 Dermatologic Agents Phase 4
27 Vaccines Phase 4
28 Immunologic Factors Phase 4
29 Immunosuppressive Agents Phase 4
30 Pharmaceutical Solutions Phase 4
31
Etanercept Approved, Investigational Phase 3 185243-69-0
32
Rivaroxaban Approved Phase 3 366789-02-8
33
Alendronate Approved Phase 3 121268-17-5, 66376-36-1 2088
34
Cyclobenzaprine Approved Phase 3 303-53-7 2895
35
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
36
Leuprolide Approved, Investigational Phase 3 53714-56-0 3911 657181
37
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
38
Alfacalcidol Approved, Nutraceutical Phase 3 41294-56-8 5282181
39 Antineoplastic Agents, Immunological Phase 2, Phase 3
40 glucocorticoids Phase 3
41 Anti-Inflammatory Agents Phase 3
42 Gastrointestinal Agents Phase 3
43 Anti-Inflammatory Agents, Non-Steroidal Phase 3
44 Serine Proteinase Inhibitors Phase 3
45 Antithrombin III Phase 3
46 Antithrombins Phase 3
47 Factor Xa Inhibitors Phase 3
48 HIV Protease Inhibitors Phase 3
49 Anticoagulants Phase 3
50
protease inhibitors Phase 3

Interventional clinical trials:

(show top 50) (show all 174)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
2 Combined Pneumococcal Conjugate and Polysaccharide Vaccination in Inflammatory Rheumatic Disease. Impact of Antirheumatic Treatment on Antibody Response. Completed NCT03762824 Phase 4
3 Patient Self-administration of Cortisol for Cortisol-responding Disorders in Men and Women Over the Age of 17, Demonstration of Double-blind Trial Results Completed NCT03558971 Phase 4 Cortisol
4 A Prospective, Randomised, Uncontrolled, Single-Centre, Post-Market Surveillance Study To Evaluate The Performance Of SmartSet® HV and SmartSet® GHV Bone Cements In Primary Cemented Total Hip Arthroplasty(THA) Completed NCT00872066 Phase 4
5 Prospective Cohort Study of the Influence of Age, Underlying Disease and Immunosuppression on Vaccine Responses to Influenza A H1N1/09 Immunization in High-risk Patients. Completed NCT01022905 Phase 4
6 Acetaminophen for Mood and Memory Changes Associated With Prednisone Therapy Completed NCT00377364 Phase 4 Drug: Acetaminophen, Drug: Placebo
7 A Prospective, Randomised, Controlled, Single Centre, Blinded Study of the Wear Characteristics of Two Polyethylene Bearing Surfaces, Enduron vs. Marathon Completed NCT00208442 Phase 4
8 Abatacept to Silence Anti-citrullinated Protein Antibody-expressing B Cells in Rheumatoid Arthritis (ASCARA). Recruiting NCT03492658 Phase 4 Abatacept;Methotrexate
9 Immunogenicity and Safety of the CoronaVac Vacccine in Patients With Autoimmune Rheumatic Diseases and People Living With HIV/AIDS Recruiting NCT04754698 Phase 4
10 EFFECTS OF ABATACEPT ON THE PROGRESSION TO RHEUMATOID ARTHRITIS IN PATIENTS WITH PALINDROMIC RHEUMATISM (PALABA) Not yet recruiting NCT03669367 Phase 4 Abatacept Injection;hydroxycloroquina
11 Safety and Immunogenicity of a Recombinant Subunit Herpes Zoster Vaccine in Patients With Rheumatic Diseases Undergoing Immunosuppressive or Biologic/Targeted DMARD Therapies: a Double-blind Randomized Placebo-controlled Trial Not yet recruiting NCT04748939 Phase 4
12 Randomised, Controlled, Prospective, Multi-Centre, Post Market Surveillance Study Comparing a Ceramic-on-Metal Bearing and a Metal-on-Metal Bearing in Subjects Requiring Primary Total Hip Arthroplasty for Non-Inflammatory Degenerative Joint Disease Terminated NCT00873444 Phase 4
13 Prospective Single-centre, Uncontrolled, Post Marketing Surveillance Study to Monitor the Long-term Performance of the DePuy ASR™ Hip in Subjects With Suitable Indications for a Primary Resurfacing Hip Arthroplasty Terminated NCT00872794 Phase 4
14 Prospective, Uncontrolled, Two-centre, RSA, Post-market Surveillance Study to Evaluate the Stability of the C-Stem™ AMT Femoral Component in Primary Total Hip Arthroplasty. Terminated NCT00872573 Phase 4
15 Prospective, International Multi-centre, Uncontrolled, Post Marketing Surveillance Study to Monitor the Long-term Performance of a Large Metal-on-Metal (MoM) Bearing Comprising a DePuy ASR™ Cup in Conjunction With Either a DePuy ASR™ Hip Resurfacing Femoral Component or a DePuy ASR™ XL Head in Subjects With Indications Suitable for Either a Primary Resurfacing Arthroplasty or Primary Total Hip Arthroplasty Terminated NCT00872547 Phase 4
16 Uncontrolled Prospective Multi-Centre Post Marketing Surveillance Study to Monitor the Long Term Survivorship of Pinnacle™ Acetabular Cup Prosthesis With a Ceramic-on-ceramic Bearing in Subjects With Aetiologies Requiring a Primary Total Hip Replacement Terminated NCT00872222 Phase 4
17 Prospective, Uncontrolled, Multi-Centre, Post-Marketing Surveillance Study to Evaluate the Long-Term Performance of Summit Tapered Hip in Cementless Total Hip Arthroplasty Terminated NCT00208390 Phase 4
18 Uncontrolled Prospective Multi-Centre Post Marketing Surveillance Study to Monitor the Long Term Survivorship of Pinnacle Acetabular Cup Prosthesis With a Metal on Metal Bearing in Subjects With Aetiologies Requiring a Primary Total Hip Replacement Terminated NCT00208364 Phase 4
19 Prospective Multi-Centre, Uncontrolled, Post Marketing Surveillance Study to Monitor the Long-Term Performance of the DePuy ASR Hip System in Subjects With Suitable Indications for a Primary Resurfacing Hip Arthroplasty Terminated NCT00208377 Phase 4
20 Uncontrolled Prospective Multi-Centre Post Marketing Surveillance Study to Monitor the Long Term Survivorship of Pinnacle Acetabular Cup System With a Metal on Enduron Polyethylene Bearing in Subjects With Aetiologies Requiring a Primary Total Hip Replacement Withdrawn NCT00208429 Phase 4
21 Double-Blind, Parallel-group Comparison, Investigators Initiated Phase II Clinical Trial of IDEC-C2B8 (Rituximab) in Patients With Systemic Sclerosis Completed NCT04274257 Phase 2, Phase 3 Double-Blind Placebo;Double-Blind Rituximab
22 A Phase 3, Double-Blind, Randomized, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TNX-102 SL Tablets Taken Daily at Bedtime in Patients With Fibromyalgia Completed NCT02436096 Phase 3 TNX-102 SL Tablet, 2.8mg;Placebo SL Tablet
23 DOES ETANERCEPT INFLUENCE TWEAK MODULATION OF INFLAMMATION DURING INFLAMMATORY RHEUMATISMS (PSORIATIC ARTHRITIS AND RHEUMATOID ARTHRITIS)? Completed NCT02164214 Phase 3 etanercept Treatment
24 Medically Ill Patient Assessment of Rivaroxaban Versus Placebo in Reducing Post-Discharge Venous Thrombo-Embolism Risk Completed NCT02111564 Phase 3 Rivaroxaban, 10 mg;Rivaroxaban, 7.5 mg;Placebo
25 Prevention of Glucocorticoid-Induced Osteoporosis in Patients With Rheumatic Diseases. The STOP-Study: a Randomized Placebo Controlled Trial With Alendronate Versus Alfacalcidol. Completed NCT00138983 Phase 3 Alendronate versus alfacalcidol (1-alpha OH vitamin D)
26 COVID-19 Vaccine in Immunosuppressed Adults With Autoimmune Diseases Recruiting NCT04806113 Phase 3
27 A Phase 3, Double-Blind, Randomized, Multicenter, Placebo-Controlled Study To Evaluate The EFFIcacy and Safety of TNX-102 SL Tablets Taken Daily At Bedtime In Patients With FibRoMyalgia Terminated NCT02829814 Phase 3 TNX-102 SL Tablet, 2.8 mg;Placebo SL Tablet
28 GnRH-a for Ovarian Protection During CYC Therapy for Rheumatic Diseases Terminated NCT01257802 Phase 3 depot leuprolide acetate 3.75 mg;Placebo
29 A Multi-centre, Randomised, Parallel Group, Controlled Study to Compare the Performance of the Future Hip Against Three Currently Used Implants in Total Hip Replacement Terminated NCT00208468 Phase 3
30 Clinical and Radiographic Evaluation to Compare a Polished and Non-polished Collared Stem and a Polished and Non Polished Collarless Stem in Primary Total Hip Replacement Terminated NCT00208351 Phase 3
31 Efficacy and Safety of Vaccination Against Influenza H1N1 in Patients With Rheumatoid Arthritis, Systemic Lupus Erythematosus, Psoriatic Arthritis and Ankylosing Spondylitis Treated With Immunomodulatory Drugs Unknown status NCT01006681 Phase 2
32 Intraarticular Application of Opioids Versus Glucocorticosteroids Versus Placebo in Rheumatoid Arthritis Unknown status NCT00244153 Phase 1, Phase 2 intraarticular morphine;intraarticular dexamethasone
33 Immunogenicity and Efficacy of High-dose Trivalent Inactivated Seasonal Influenza Vaccine (Fluzone High Dose) in Immunocompromised Children and Young Adults. Completed NCT01685372 Phase 2
34 Articular Cartilage Regeneration in Gonarthrosis Grade II and III by Articular Infiltration of Xcel-m-condro-alpha. Completed NCT01227694 Phase 1, Phase 2
35 Improving Vocational Outcomes in Arthritis Completed NCT00000407 Phase 2
36 A Randomized, Double-Blind, Placebo-Controlled, Titration-to-Effect Study of Orally Administered CR845 in Patients With Osteoarthritis of the Hip or Knee Completed NCT02944448 Phase 2 CR845 tablet 1 mg;CR845 tablet 2.5 mg;CR845 tablet 5 mg;Placebo tablet
37 Booster Vaccine Strategy to Improve Serologic Responses to Influenza Vaccination in Children With Rheumatic Diseases and Inflammatory Bowel Disease Who Are Receiving Immunosuppressive Therapies Recruiting NCT03277703 Phase 2
38 Treatment of Refractory Hemochromatosis Rheumatism by Anakinra: a Preliminary Phase II Study Terminated NCT02263638 Phase 2 Anakinra
39 An Ascending Single- and Multiple-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous Gimsilumab in Healthy Subjects and Subjects With Ankylosing Spondylitis Completed NCT04205851 Phase 1 KIN-1901;Placebo
40 An Open, Dose Escalation, Single Dose Study to Assess Tolerance and Pharmacokinetics of T0001 in Healthy Adult Chinese Volunteers Completed NCT02291471 Phase 1 T0001,10mg;T0001,20mg;T0001,35mg;T0001,50mg;T0001,65mg;T0001,75mg
41 Safety/Efficacy of Intra-articular Administration of Autologous Tolerogenic Dendritic Cells for Treatment of Patients With Rheumatoid Arthritis Completed NCT03337165 Phase 1
42 Pilot Study Characterizing Aerobic Exercise in Women With Systemic Lupus Erythematosus (Exercise SLE Pilot). Completed NCT03186794 Phase 1
43 Identification of Epigenetic Biomarkers for Early Detection of Rheumatic Disease Unknown status NCT02742337
44 Health Related Quality of Life After a Self-promoting Problem-based Learning Program for People With Rheumatic Diseases: a Randomized Controlled Trial Unknown status NCT00803491
45 Prediction of Methotrexate Response - A Pilot Study Unknown status NCT01726959
46 Disease Activity in Rheumatoid Arthritis and Systemic Lupus Erythematosus and Its Relation to Muscle Performance,Fatigue and Blood Parameters Unknown status NCT03728231
47 Nurse-led Clinic for Patients With Rheumatic Diseases and Biological Treatment:a Randomized Controlled Trial Comparing Nurse-led Clinic Versus Rheumatologist Clinic Unknown status NCT01071447
48 Fertility Study of Women With Chronic Inflammatory Rheumatism Unknown status NCT03452735
49 Analysis of Changes in Medication Prescriptions After Hospitalization for 4 Disciplines: Gerontology, Diabetology, Cardiology and Rheumatology: Medical, Pharmaceutical and Economic Aspects Unknown status NCT03371303
50 Clinical Evolution of Patients Suffering From Lower Limb Rheumatological Conditions 6 Months After Spa Treatment Unknown status NCT03538470

Search NIH Clinical Center for Collagen Disease

Inferred drug relations via UMLS 70 / NDF-RT 51 :


prednisolone
prednisolone acetate
PREDNISOLONE ACETATE PWDR
PREDNISOLONE PWDR
Prednisolone sodium phosphate
prednisolone tebutate
Prednisone
PREDNISONE PWDR

Cochrane evidence based reviews: collagen diseases

Genetic Tests for Collagen Disease

Anatomical Context for Collagen Disease

MalaCards organs/tissues related to Collagen Disease:

40
Bone, Bone Marrow, Eye, Liver, Endothelial, Neutrophil, Skin

Publications for Collagen Disease

Articles related to Collagen Disease:

(show top 50) (show all 2705)
# Title Authors PMID Year
1
Stability junction at a common mutation site in the collagenous domain of the mannose binding lectin. 61 54
15697204 2005
2
[Clinical significance of cytokine and cytokine receptor analysis in collagen diseases]. 61 54
14621587 2003
3
[Contribution of Japanese researchers to progress in the study of allergy and collagen disease in the last 100 years: Cytokines and cytokine receptors]. 61 54
12373883 2002
4
Changes in plasma serotonin concentration and acceleration plethysmograms in patients with Raynaud's phenomenon after long-term treatment with a 5-HT2 receptor antagonist. 61 54
11092268 2000
5
Increase in plasma thrombomodulin level in patients with vibration syndrome. 54 61
8731509 1996
6
Pulmonary surfactant protein D in sera and bronchoalveolar lavage fluids. 61 54
8520747 1995
7
[Evaluation of serum thrombomodulin in patients with interstitial pneumonia]. 61 54
7844912 1994
8
[Detection of anticardiolipin antibody using the EIA kit prepared to eliminate interference of serum cofactor]. 61 54
8371506 1993
9
Addition of serum from patients with collagen diseases increases to cultured human endothelial cells production and release of von Willebrand factor. 54 61
8438904 1993
10
Circulating thrombomodulin as a novel endothelial cell marker: comparison of its behavior with von Willebrand factor and tissue-type plasminogen activator. 54 61
1323930 1992
11
Plasma coagulation and fibrinolysis parameters in patients with collagen diseases, and analysis of the multimeric structure of von Willebrand factor (vWF). 61 54
1756253 1991
12
Quetiapine-induced thrombotic microangiopathy in a patient on maintenance dialysis. 61
32981026 2021
13
Elevated C-reactive protein is significantly associated with left ventricular dysfunction in patients with aortic regurgitation and concomitant collagen disease. 61
33359278 2021
14
Heterogeneity of eye drop use among symptomatic dry eye individuals in Japan: large-scale crowdsourced research using DryEyeRhythm application. 61
33411099 2021
15
Psoriasis: Pathogenesis, Comorbidities, and Therapy Updated. 61
33804147 2021
16
Lipid Formulations and Bioconjugation Strategies for Indomethacin Therapeutic Advances. 61
33809343 2021
17
Metastatic Infiltration of Anaplastic Carcinoma of the Pancreas Into the Portal Venous System: A Masquerading Cause of Expansive Portal Venous Thrombosis. 61
33767127 2021
18
Gastrointestinal dysfunction in neuroinflammatory diseases: Multiple sclerosis, neuromyelitis optica, acute autonomic ganglionopathy and related conditions. 61
33740560 2021
19
A Case of Diffuse Alveolar Hemorrhage Associated with Dilated Cardiomyopathy and Sleep Apnea Syndrome. 61
33518557 2021
20
[A Case of Immune-Mediated Necrotizing Myopathy Associated with Primary Sjögren Syndrome]. 61
33561833 2021
21
Rituximab used for simultaneous treatment of PR3-ANCA positive vasculitis associated with rheumatoid arthritis: A case report. 61
33363811 2020
22
Recent epidemiology of Pneumocystis pneumonia in Japan. 61
32753118 2020
23
Glomerular filtration and podocyte tensional homeostasis: importance of the minor type IV collagen network. 61
32462439 2020
24
Genotype-phenotype correlations influence the response to angiotensin-targeting drugs in Japanese patients with male X-linked Alport syndrome. 61
32712167 2020
25
Multiple cardiac complications associated with collagen disease. 61
33215326 2020
26
Fluoroquinolones Are Associated With Increased Risk of Aortic Aneurysm or Dissection: Systematic Review and Meta-analysis. 61
33181305 2020
27
Two Cases of Wells Syndrome with Marked Swelling in the Hands. 61
33344351 2020
28
Lower Extremity Non-Blanchable Purpura Secondary to Methotrexate Toxicity: A Case Report. 61
32736973 2020
29
COVID-19 pandemic highlighted the importance of telemedicine in the collagen disease of systemic sclerosis. 61
33200739 2020
30
Chemotherapy-induced pneumonitis associated with transient CA 15-3 elevation. 61
32075504 2020
31
Autoimmune Myelofibrosis in Sjögren's Syndrome: Report of a Case. 61
32956337 2020
32
A case of severe choroidal detachment in both eyes due to systemic lupus erythematosus. 61
32695932 2020
33
[Coronary Artery Bypass Grafting for Coronary Aneurysms Causing Acute Myocardial Infarction;Report of a Case]. 61
32879287 2020
34
A graphene oxide-aided triple helical aggregation-induced emission biosensor for highly specific detection of charged collagen peptides. 61
32568343 2020
35
Chloroquine in controlling biological infections. 61
32564047 2020
36
Suspected Virus-Inducing Severe Acute Respiratory Distress Syndrome Treated by Multimodal Therapy Including Extracorporeal Membrane Oxygenation and Immune Modulation Therapy. 61
32714705 2020
37
Increased CD27 expression in the skins and sera of patients with systemic sclerosis. 61
32494557 2020
38
Recurrent pneumothorax and intrapulmonary cavitary lesions in a male patient with vascular Ehlers-Danlos syndrome and a novel missense mutation in the COL3A1 gene: a case report. 61
32471395 2020
39
Diagnostic markers for community-acquired pneumonia. 61
32566635 2020
40
Lower Activity and Function Scores Are Associated with a Higher Risk of Preoperative Deep Venous Thrombosis in Patients Undergoing Total Hip Arthroplasty. 61
32357497 2020
41
Retinal vascular inflammatory and occlusive changes in infectious and non-infectious uveitis. 61
32016664 2020
42
Impact of Therapeutic Angiogenesis Using Autologous Bone Marrow-derived Mononuclear Cell Implantation in Patients with No-option Critical Limb Ischemia. 61
32273917 2020
43
Takotsubo cardiomyopathy complicated by cardiac tamponade due to non-hemorrhagic pericardial effusion: a case report. 61
32028901 2020
44
Case report: vertebral osteomyelitis secondary to a dental abscess. 61
32050917 2020
45
A case of imatinib-related obstructive bronchiolitis followed long term. 61
32300523 2020
46
Effect of THBS1 on the Biological Function of Hypertrophic Scar Fibroblasts. 61
33376743 2020
47
Magnetic resonance imaging of intraocular optic nerve disorders: review article. 61
32467740 2020
48
Acquired Factor XI Deficiency with Lupus Anticoagulant in a Pregnant Woman Diagnosed by the Eruptions and Pain in Fingers. 61
33489393 2020
49
[Successful management of cold agglutinin syndrome developing subsequent to rheumatoid arthritis with immunosuppressive therapy]. 61
32759559 2020
50
[AN ADULT CASE OF PERIODIC FEVER, APHTHOUS STOMATITIS, PHARYNGITIS, AND ADENITIS (PFAPA) SYNDROME DEVELOPED IN CHILDHOOD AND DIAGNOSED AFTER PROGRESS MORE THAN 30 YEARS]. 61
32051370 2020

Variations for Collagen Disease

Expression for Collagen Disease

Search GEO for disease gene expression data for Collagen Disease.

Pathways for Collagen Disease

Pathways related to Collagen Disease according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.18 ELN COL5A2 COL5A1 COL3A1 COL2A1 COL27A1
2
Show member pathways
12.81 ELN COL5A2 COL5A1 COL3A1 COL2A1 COL27A1
3
Show member pathways
12.63 VWF TNXB COL5A2 COL5A1 COL3A1 COL2A1
4
Show member pathways
12.34 THBD PLOD1 ELN COL5A2 COL5A1 COL3A1
5
Show member pathways
11.93 TNXB PLOD1 ELN COL5A2 COL5A1 COL3A1
6
Show member pathways
11.9 VWF TNXB COL2A1 COL1A1
7 11.78 VWF COL3A1 COL1A1
8 11.65 THBD COL3A1 COL1A1
9 11.42 COL3A1 COL2A1 COL1A1
10 11.32 VWF COL3A1 COL1A1
11 11.09 TNXB COL5A2 COL5A1 COL3A1
12 10.7 ELN COL5A2 COL5A1 COL3A1 COL2A1 COL27A1

GO Terms for Collagen Disease

Cellular components related to Collagen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.13 VWF TNXB SFTPD SERPINA3 NPPA ELN
2 extracellular space GO:0005615 10.07 VWF TNXB THBD SFTPD SERPINA3 NPPA
3 endoplasmic reticulum lumen GO:0005788 9.85 COL5A2 COL5A1 COL3A1 COL2A1 COL27A1 COL1A1
4 collagen trimer GO:0005581 9.7 SFTPD COL5A2 COL5A1 COL3A1 COL2A1 COL27A1
5 extracellular matrix GO:0031012 9.61 VWF TNXB ELN COL5A2 COL5A1 COL3A1
6 collagen type V trimer GO:0005588 9.4 COL5A2 COL5A1
7 collagen-containing extracellular matrix GO:0062023 9.4 VWF TNXB SERPINA3 NPPA ELN COL5A2

Biological processes related to Collagen Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 regulation of immune response GO:0050776 9.78 SFTPD COL3A1 COL2A1 COL1A1
2 platelet degranulation GO:0002576 9.74 VWF SERPINA3 APOH
3 platelet activation GO:0030168 9.72 VWF COL3A1 COL1A1
4 ossification GO:0001503 9.71 COL5A2 COL2A1 COL1A1
5 skeletal system development GO:0001501 9.71 COL5A2 COL3A1 COL2A1 COL1A1
6 blood coagulation, intrinsic pathway GO:0007597 9.56 VWF APOH
7 negative regulation of blood coagulation GO:0030195 9.52 THBD APOH
8 negative regulation of fibrinolysis GO:0051918 9.51 THBD APOH
9 collagen biosynthetic process GO:0032964 9.49 COL5A1 COL1A1
10 proteoglycan metabolic process GO:0006029 9.46 COL2A1 B4GALT7
11 skin development GO:0043588 9.46 COL5A2 COL5A1 COL3A1 COL1A1
12 cartilage development involved in endochondral bone morphogenesis GO:0060351 9.43 COL2A1 COL1A1
13 supramolecular fiber organization GO:0097435 9.43 COL5A1 COL3A1 B4GALT7
14 collagen fibril organization GO:0030199 9.43 TNXB COL5A2 COL5A1 COL3A1 COL2A1 COL1A1
15 eye morphogenesis GO:0048592 9.37 COL5A2 COL5A1
16 negative regulation of endodermal cell differentiation GO:1903225 9.32 COL5A2 COL5A1
17 extracellular matrix organization GO:0030198 9.28 VWF TNXB ELN COL5A2 COL5A1 COL3A1

Molecular functions related to Collagen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.56 VWF TNXB COL5A1 COL3A1
2 protease binding GO:0002020 9.54 VWF COL3A1 COL1A1
3 platelet-derived growth factor binding GO:0048407 9.46 COL5A1 COL3A1 COL2A1 COL1A1
4 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.43 COL5A2 COL5A1 COL3A1 COL2A1 COL27A1 COL1A1
5 proteoglycan binding GO:0043394 9.32 COL5A1 COL2A1
6 extracellular matrix structural constituent GO:0005201 9.28 VWF TNXB ELN COL5A2 COL5A1 COL3A1

Sources for Collagen Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....