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MCID: CLL015
MIFTS: 46

Collagen Disease

Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Collagen Disease

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MalaCards integrated aliases for Collagen Disease:

Name: Collagen Disease 12 15
Collagen Diseases 55 44 73
Collagen Disorder 12 76

External Ids:

Disease Ontology 12 DOID:854
MeSH 44 D003095
NCIt 50 C27204
SNOMED-CT 68 81573002
UMLS 73 C0009326
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Summaries for Collagen Disease

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Disease Ontology : 12 A connective tissue disease that characterized by connective tissue disease that has_material_basis in inheritable defects in collagen.

MalaCards based summary : Collagen Disease, also known as collagen diseases, is related to rheumatic disease and ehlers-danlos syndrome. An important gene associated with Collagen Disease is RPL7 (Ribosomal Protein L7), and among its related pathways/superpathways are Phospholipase-C Pathway and Focal Adhesion. The drugs leucovorin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and lung, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 A connective tissue disease is any disease that has the connective tissues of the body as a target of... more...

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Related Diseases for Collagen Disease

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Diseases in the Collagen Disease family:

Collagen Type Vi-Related Disorders

Diseases related to Collagen Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 rheumatic disease 31.6 CENPB SSB TLR9 TOP1 TRIM21
2 ehlers-danlos syndrome 31.2 B4GALT7 COL1A2 COL3A1 COL5A1 COL5A2 PLOD1
3 systemic scleroderma 30.3 CCN2 CENPB EDN1 EXOSC10 FBN1 SCHIP1
4 systemic lupus erythematosus 29.9 CENPB RPL7 SNRNP70 SSB TLR9 TRIM21
5 scleroderma, familial progressive 29.9 COL1A2 EDN1 FBN1 TOP1
6 hypermobile ehlers-danlos syndrome 29.7 FBN1 PLOD1
7 diffuse scleroderma 29.5 TOP1 TRIM21
8 connective tissue disease 28.4 CCN2 CENPB COL1A2 COL3A1 COL5A1 EDN1
9 disseminated eosinophilic collagen disease 12.2
10 alpha-2-deficient collagen disease 12.1
11 hypereosinophilic syndrome 11.0
12 mixed connective tissue disease 10.8
13 bone fragility with contractures, arterial rupture, and deafness 10.8
14 collagenopathy, types ii and xi 10.8
15 familial abdominal aortic aneurysm 10.3 COL3A1 FBN1
16 ehlers-danlos syndrome, vascular type 10.3 COL3A1 COL5A1
17 familial thoracic aortic aneurysm and dissection 10.3 COL3A1 FBN1
18 ehlers-danlos syndrome, classic type, 2 10.2 COL3A1 COL5A1 COL5A2
19 larsen-like syndrome 10.2 COL1A2 COL3A1 COL5A2
20 hypomelanosis of ito 10.2 COL5A1 PLOD1
21 hypermobility syndrome 10.2 COL3A1 COL5A1 TNXB
22 cervical incompetence 10.2 COL5A2 PLOD1
23 loeys-dietz syndrome 10.2 COL3A1 COL5A2 FBN1
24 lipoblastoma 10.2 COL1A2 COL3A1
25 crest syndrome 10.2 CENPB TOP1
26 raynaud disease 10.2 EDN1 TOP1
27 lupus erythematosus 10.2
28 ehlers-danlos syndrome, classic type, 1 10.2 COL1A2 COL3A1 COL5A1 COL5A2
29 facial hemiatrophy 10.2 EXOSC10 SNRNP70 TRIM21
30 orthostatic intolerance 10.2 EDN1 FBN1 PLOD1
31 classic ehlers-danlos syndrome 10.2 COL1A2 COL5A1 COL5A2 TNXB
32 autoimmune disease of urogenital tract 10.2 CENPB SCHIP1 TLR9
33 marfan syndrome 10.1 COL1A2 COL3A1 COL5A2 FBN1
34 idiopathic interstitial pneumonia 10.1 CCN2 EDN1 TLR9
35 stiff skin syndrome 10.1 CCN2 COL1A2 FBN1
36 urinary system disease 10.1 CCN2 EDN1 TLR9
37 muscular disease 10.1 EXOSC10 SNRNP70 TLR9 TRIM21
38 dyskinesia of esophagus 10.1 CENPB TOP1
39 immune system disease 10.1 SCHIP1 SSB TLR9 TRIM21
40 caspase 8 deficiency 10.1 COL5A1 COL5A2
41 limited scleroderma 10.0 CCN2 CENPB SNRNP70 TOP1 TSSK1B
42 arthritis 9.9
43 pneumonia 9.9
44 autoimmune disease of musculoskeletal system 9.8 CENPB EXOSC10 SNRNP70 SSB TLR9 TOP1
45 rheumatoid arthritis 9.8
46 rheumatic fever-related antigen 9.8
47 rheumatic fever 9.8
48 polyarteritis nodosa, childhood-onset 9.8
49 pulmonary hypertension 9.8
50 diabetes mellitus 9.8

Graphical network of the top 20 diseases related to Collagen Disease:



Diseases related to Collagen Disease
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Symptoms & Phenotypes for Collagen Disease

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GenomeRNAi Phenotypes related to Collagen Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 10.15 RPL7
2 Decreased viability GR00221-A-1 10.15 COL3A1 EXOSC10
3 Decreased viability GR00221-A-2 10.15 COL3A1 EXOSC10
4 Decreased viability GR00221-A-4 10.15 COL3A1
5 Decreased viability GR00240-S-1 10.15 RPL7 TRIM21
6 Decreased viability GR00342-S-1 10.15 EXOSC10
7 Decreased viability GR00381-A-1 10.15 PLOD1 RPL7
8 Decreased viability GR00402-S-2 10.15 B4GALT7 CCN2 CENPB COL1A2 COL3A1 COL5A1
9 no effect GR00402-S-1 9.62 B4GALT7 CCN2 CENPB COL1A2 COL3A1 COL5A1

MGI Mouse Phenotypes related to Collagen Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 CCN2 COL1A2 COL3A1 COL5A1 COL5A2 EDN1
2 integument MP:0010771 9.61 CCN2 COL1A2 COL3A1 COL5A1 COL5A2 FBN1
3 mortality/aging MP:0010768 9.5 CCN2 CENPB COL1A2 COL3A1 COL5A1 COL5A2
Sources

Drugs & Therapeutics for Collagen Disease

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Drugs for Collagen Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 984)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 6006 143
2
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-05-2, 1959-05-2 126941
3
Leflunomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 75706-12-6 3899
4
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 185243-69-0
5
Sulfasalazine Approved Phase 4,Phase 3,Phase 2,Not Applicable 599-79-1 5353980 5359476
6
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 170277-31-3
7
Hydroxychloroquine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 118-42-3 3652
8
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 302-25-0
9
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 16590-41-3 5360515
10
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-24-8 5755
11
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 83-43-2 6741
12
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2921-57-5
13
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 124-94-7 31307
14
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 9004-61-9 53477741
15
Tranylcypromine Approved, Investigational Phase 4 155-09-9 441233
16
Heparin Approved, Investigational Phase 4,Phase 3,Not Applicable 9005-49-6 772 46507594
17
Thrombin Approved, Investigational Phase 4,Phase 2
18
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1197-18-8 5526
19
Dalteparin Approved Phase 4,Phase 3,Not Applicable 9005-49-6
20
Enoxaparin Approved Phase 4,Phase 3,Not Applicable 9005-49-6 772
21
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-84-3 187
22
Glucosamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 3416-24-8 439213
23
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 103-90-2 1983
24
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
25
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 1177-87-3
26
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
27
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 378-44-9 9782
28
Ketorolac Approved Phase 4,Phase 3,Phase 2,Not Applicable 66635-83-4, 74103-06-3 3826
29
Iron Approved Phase 4,Phase 3,Phase 1,Phase 2 7439-89-6 23925
30
Rivaroxaban Approved Phase 4,Phase 3,Not Applicable 366789-02-8
31
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22204-53-1 1302 156391
32
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 161796-78-7, 119141-88-7 4594 9579578
33
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 169590-42-5 2662
34
Chitosan Approved Phase 4,Not Applicable 9012-76-4 71853
35
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
36
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Not Applicable 84057-95-4 175805 71273
37
Fluorouracil Approved Phase 4 51-21-8 3385
38
Cimetidine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 51481-61-9 2756
39
Hyoscyamine Approved Phase 4,Not Applicable 101-31-5 64692
40
Milnacipran Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 92623-85-3 65833
41
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-41-2 439260
42
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
43 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 202409-33-4 123619
45
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 331731-18-1 16219006
46
Tacrolimus Approved, Investigational Phase 4,Phase 3,Early Phase 1 104987-11-3 445643 439492
47
Abatacept Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 332348-12-6 10237
48
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 15307-86-5 3033
49
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 174722-31-7 10201696
50
Amitriptyline Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-48-6 2160

Interventional clinical trials:

(show top 50) (show all 6562)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
2 Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis Unknown status NCT02087696 Phase 4 Tocilizumab
3 Vaccination Against Pertussis, Tetanus and Diphtheria in Patients Suffering From Rheumatoid Arthritis Unknown status NCT01301703 Phase 4
4 Efficacy Study of Leflunomide to Treat Juvenile Idiopathic Arthritis Unknown status NCT02024334 Phase 4 Leflunomide
5 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
6 TNF-blocking Therapy in Combination With Disease-modifying Antirheumatic Drugs in Early Rheumatoid Arthritis Unknown status NCT00908089 Phase 4 Trexan+Salazopyrin+Oxiklorin+prednisolone + infliximab;Trexan+Salazopyrin+Oxiklorin+prednisolone + placebo
7 Obesity Cohort : Medical Follow-up of Severe or Morbid Obese Patients Undergoing Bariatric Surgery Unknown status NCT02310178 Phase 4
8 Very Early Versus Delayed Etanercept in Patients With RA Unknown status NCT02433184 Phase 4 Etanercept;Methotrexate;Sulfasalazine;Hydroxychloroquine;Etanercept;Methotrexate
9 Pilot Study to Evaluate Clinical Outcomes With the Use of Biovance Following Keloid Scar Revision Surgery Unknown status NCT02521402 Phase 4
10 Additional Effects of Triamcinolone to Hyaluronic Acid on Knee Osteoarthritis Unknown status NCT02949466 Phase 4 Triamcinolone
11 Topical Tranexamic Acid and Floseal® in Total Knee Arthroplasty Unknown status NCT02865174 Phase 4 Topical tranexamic acid;Floseal®;Enoxaparin
12 Influence of Perception of Patients Suffering of Knee Osteoarthritis Regarding Effectiveness of Intra-articular Injection Unknown status NCT02835521 Phase 4 Joint injection with triamcinolone hexacetonide
13 Intra-articular Botox Type A Versus Corticosteroids in Knee Osteoarthritis Unknown status NCT02829281 Phase 4 Botulinum Toxin Type A;Triamcinolone hexacetonide;Saline
14 Primary Care Study With Chondroitin Sulfate and Glucosamine Hydrochloride in Hand Osteoarhritis Unknown status NCT02823548 Phase 4 Droglican;Placebo
15 Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN Unknown status NCT02821468 Phase 4 Droglican;Paracetamol or oral NSAIDs excluding COX2 inhibitors
16 Effects of Perioperative Intravenous Dexamethasone on the Severity of Persistent Postsurgical Pain After Total Knee Arthroplasty : A Prospective, Randomized, Double-blind, Placebo-controlled Trial Unknown status NCT02760459 Phase 4 Dexamethasone;Normal saline solution
17 Assessment of a Knee Brace in Patients With Osteoarthritis Unknown status NCT02706106 Phase 4
18 Effectiveness of Trapeziometacarpal Splint Unknown status NCT02635932 Phase 4
19 26 Week Open Label Study Evaluating Single IA Injection of DUROLANE SJ for Treatment of Osteoarthritis Pain of the Ankle Unknown status NCT02627859 Phase 4
20 Effects of Hyaluronic Acid vs. Hyaluronic Acid on Knee Osteoarthritis Unknown status NCT02625727 Phase 4
21 Comparing Intra-articular Corticosteroid to Intra-articular Ketorolac Knee Injections Unknown status NCT02612272 Phase 4 Ketorolac;Betamethasone
22 Intravenous Iron Sucrose in Arthroplasty Unknown status NCT02544828 Phase 4 Iron Sucrose 200mg;placebo
23 The Post-marketing Surveillance to Evaluate the Efficacy of CHONDRON (Autologous Cultured Chondrocyte) by Arthroscopy Unknown status NCT02539069 Phase 4
24 The Post-marketing Surveillance to Evaluate the Efficacy and Safety of a CHONDRON (Autologous Cultured Chondrocyte) Unknown status NCT02539056 Phase 4
25 Multi-center Clinical Study of Guli Capsules in the Treatment of Knee Osteoarthritis Unknown status NCT02484508 Phase 4 Guli capsule;Kangguzengsheng capsule
26 Comparison of Topical and Infusion Tranexamic Acid After Total Knee Arthroplasty Unknown status NCT02453802 Phase 4 Tranexamic Acid 5%,5ml/amp;Tranexamic Acid 5%,5ml/amp;rivaroxaban (10mg);0.9% Normal Saline;0.9% Normal Saline
27 Validation of a Stress Device for the Knee Unknown status NCT02444663 Phase 4
28 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
29 Medical Chitosan or Sodium Hyaluronate for Knee Osteoarthritis (CHOOSE) Unknown status NCT02323451 Phase 4 Sodium Hyaluronate Injection
30 Tranexamic Acid in Knee Joint Surgery Unknown status NCT02278263 Phase 4 Tranexamic Acid;Normal saline (0.9% NaCl)
31 Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty Unknown status NCT02152917 Phase 4 Tranexamic acid;Floseal®
32 Intraarticular Xylitol Injections for Knee Osteoarthritis Unknown status NCT02104596 Phase 4
33 The Effect of Spironolactone on Pain in Older People With Osteoarthritis Unknown status NCT02046668 Phase 4 spironolactone
34 Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy Unknown status NCT02000297 Phase 4
35 A Phase 4 Study of Imrecoxib in Treatment of Knee Osteoarthritis Unknown status NCT01985165 Phase 4 Imrecoxib
36 Comparison of Femoral Nerve Catheter and Adductor Canal Block With Steroid Adjuvant in Total Knee Replacement (TKR) Unknown status NCT01973530 Phase 4
37 Keloid Scarring: Treatment and Pathophysiology Unknown status NCT01295099 Phase 4 5- fluorouracil;Triamcinolone
38 Reinflation After Early Tourniquet Release in Total Knee Arthroplasty Unknown status NCT01832272 Phase 4
39 Hip Viscosupplementation: What is the Best Dosage? Unknown status NCT01810809 Phase 4 1 ampoule of Hylan GF-20;2 ampoules of Hylan GF-20;3 ampoules of Hylan GF-20
40 Bone Forming at Prosthetic Surfaces. Fingerprint2 Unknown status NCT01623687 Phase 4
41 RSA Study Using Two Types of Uncemented Acetabular Components and the Uncemented HA Coated Symax Stem Unknown status NCT01618084 Phase 4
42 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
43 Chondroitin Sulphate Treatment Efficacy in Rhizarthrosis. Unknown status NCT01233739 Phase 4 Chondroitin sulfate;Placebo
44 Assessment of the Effects of Chondroitin Sulphate in Patients With Knee Osteoarthritis With Functional Magnetic Resonance Imaging (fMRI) Unknown status NCT01226615 Phase 4 Chondroitin sulphate (Condrosan®);Placebo
45 Prophecy Guide Outcomes in Total Knee Replacement Surgery Unknown status NCT01163708 Phase 4
46 Comparison of Outcomes in Mobile and Fixed-bearing Total Knee Arthroplasty Unknown status NCT01027819 Phase 4
47 A Randomized Clinical Study Comparing Two Closure Techniques of Excised Keloids Unknown status NCT00519493 Phase 4
48 The Impact of Hyaluronic Acid Injections on Osteoarthritic Knee Mechanics Unknown status NCT00778076 Phase 4
49 Use of Cold and Compression Therapy With Total Knee Replacement Patients Unknown status NCT00712816 Phase 4
50 Trial Comparing Navigated and Conventional Implantation Techniques in Knee Replacement Surgery Unknown status NCT00431509 Phase 4

Search NIH Clinical Center for Collagen Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: collagen diseases

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Genetic Tests for Collagen Disease

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Anatomical Context for Collagen Disease

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MalaCards organs/tissues related to Collagen Disease:

41
Bone, Skin, Lung, Liver, Eye, T Cells, Thyroid
Sources

Publications for Collagen Disease

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Articles related to Collagen Disease:

(show top 50) (show all 479)
# Title Authors Year
1
Genetic identification of a common collagen disease in puerto ricans via identity-by-descent mapping in a health system. ( 28895531 )
2017
2
A scabies outbreak in a diabetic and collagen disease ward: Management and prevention. ( 28105102 )
2016
3
Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD. ( 26327779 )
2015
4
Serum levels of tenascin-C in collagen diseases. ( 23834524 )
2013
5
Serum biomarker analysis of collagen disease patients with acute-onset diffuse interstitial lung disease. ( 23405989 )
2013
6
Pulmonary manifestations of collagen diseases. ( 23683373 )
2013
7
Spontaneous rupture of autogenous saphenous vein graft in bypass surgery for peripheral arterial disease possibly associated with collagen disease. ( 22944580 )
2012
8
A polygene network model for the complex pathological phenotypes of collagen disease. ( 22029672 )
2011
9
Left ventricular myocardial ischemia in collagen disease associated with pulmonary hypertension: an evaluation by rest-stress gated SPECT and coronary angiography. ( 21597395 )
2011
10
Polygene network in collagen disease. ( 20453438 )
2010
11
Subcutaneous phaeohyphomycosis caused by Exophiala jeanselmei in collagen disease patient. ( 21083708 )
2010
12
Haemorrhoids - a collagen disease? ( 19614671 )
2010
13
Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease. ( 20307660 )
2010
14
Clinical features of liver dysfunction in collagen diseases. ( 20880057 )
2010
15
[Genetics of autoimmune and collagen diseases]. ( 19507500 )
2009
16
Myopia: a collagen disease? ( 19616386 )
2009
17
New aspect of anti-inflammatory action of lipo-prostaglandinE1 in the management of collagen diseases-related skin ulcer. ( 18461292 )
2008
18
Structural biology: Modelling collagen diseases. ( 18563144 )
2008
19
Unique microstructures and podocytic infolding in glomerular basement membrane associated with collagen diseases: a report of three cases. ( 18839060 )
2008
20
Is interstitial pneumonia in patients with collagen diseases a contraindication to lung cancer surgery? ( 17186339 )
2007
21
Cytokines in collagen disease-related atherogenesis. ( 17143992 )
2006
22
Serum levels of KL-6 are positively correlated with those of CA15-3 in patients with interstitial pneumonia associated with collagen diseases. ( 16771927 )
2006
23
Risk factors of abdominal surgery in patients with collagen diseases. ( 16986398 )
2006
24
Aluminum foil treatment combined with basic fibroblast growth factor (bFGF) for gangrene of the fingertip caused by collagen disease. ( 16320409 )
2005
25
Successful pregnancy outcome using sperm from severely diseased men with testicular cancer and collagen disease: Three case reports. ( 29657546 )
2004
26
Dystrophic breast calcifications in patients with collagen diseases. ( 14996440 )
2004
27
[Clinical significance of cytokine and cytokine receptor analysis in collagen diseases]. ( 14621587 )
2003
28
Post-transplantation chronic graft-versus-host disease with overlapping features similar to those of various collagen diseases. ( 12694496 )
2003
29
Gastrointestinal cytomegalovirus infection in collagen diseases. ( 12880302 )
2003
30
Gender differences in collagen diseases. ( 14673311 )
2003
31
Thoracic manifestations of the less common collagen diseases. A pictorial essay. ( 14735010 )
2003
32
[Contribution of Japanese researchers to progress in the study of allergy and collagen disease in the last 100 years: Cytokines and cytokine receptors]. ( 12373883 )
2002
33
[Contribution of Japanese researchers to progress in the study of allergy and collagen disease in the last 100 years: IL-6 and autoimmune diseases]. ( 12373879 )
2002
34
Immunomodulation by the autonomic nervous system: therapeutic approach for cancer, collagen diseases, and inflammatory bowel diseases. ( 12423529 )
2002
35
Tc-99m DTPA renography in patients with collagen disease. ( 11245107 )
2001
36
The occurrence of various collagen diseases in one family: a sister with ISSc, PBC, APS, and SS and a brother with systemic lupus erythematosus. ( 11732722 )
2001
37
Comparative evaluation of KL-6 and surfactant protein D as serum markers for interstitial pneumonia associated with collagen diseases. ( 24383687 )
2001
38
Thallium-201 myocardial SPET in patients with collagen disease. ( 11039455 )
2000
39
Genome analysis of collagen disease in MRL/lpr mice: polygenic inheritance resulting in the complex pathological manifestations. ( 10980337 )
2000
40
Genome analysis of collagen disease in MRL/lpr mice: polygenic inheritance resulting in the complex pathological manifestations ( 10980338 )
2000
41
The liver in collagen diseases: pathologic study of 160 cases with particular reference to hepatic arteritis, primary biliary cirrhosis, autoimmune hepatitis and nodular regenerative hyperplasia of the liver. ( 11092254 )
2000
42
Clinical significance of ventilation/perfusion scans in collagen disease patients. ( 11210092 )
2000
43
Genetic basis of the complex pathological manifestations of collagen disease: lessons from MRL/lpr and related mouse models. ( 11016428 )
2000
44
Diagnosis and treatment of pulmonary hypertension associated with collagen diseases. ( 10801140 )
2000
45
KL-6 as a novel serum marker for interstitial pneumonia associated with collagen diseases. ( 10813282 )
2000
46
Immunoglobulin isotypes of anti-myeloperoxidase and anti-lactoferrin antibodies in patients with collagen diseases. ( 10939715 )
2000
47
Collagen diseases in children. ( 11173207 )
2000
48
Genetic dissection of the complex pathological manifestations of collagen disease in MRL/lpr mice. ( 10594844 )
1999
49
[Clinical evaluation of serum cytokine from patients with collagen diseases]. ( 10340006 )
1999
50
Effects of nilvadipine on cytokine-levels and soluble factors in collagen disease complicated with essential hypertension. ( 10513835 )
1999
Sources

Variations for Collagen Disease

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Expression for Collagen Disease

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Search GEO for disease gene expression data for Collagen Disease.
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Pathways for Collagen Disease

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Pathways related to Collagen Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Phospholipase-C Pathway 64
Show member pathways
 12.74 CCN2 COL1A2 COL3A1 COL5A1 COL5A2 FBN1
2
Focal Adhesion 1 37
Show member pathways
 12.62 COL1A2 COL3A1 COL5A1 COL5A2 TNXB
3
Collagen chain trimerization 66
Show member pathways
 12.52 COL1A2 COL3A1 COL5A1 COL5A2 PLOD1
4
Degradation of the extracellular matrix 66
Show member pathways
 12.15 COL1A2 COL3A1 COL5A1 COL5A2 FBN1 PLOD1
5
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 11.84 COL1A2 COL3A1 COL5A1 COL5A2 FBN1 TLR9
6
AGE-RAGE signaling pathway in diabetic complications 37
11.6 COL1A2 COL3A1 EDN1
7
Endothelins 1
11.22 COL1A2 COL3A1 EDN1
8
Hypothesized Pathways in Pathogenesis of Cardiovascular Disease 1
10.88 CCN2 FBN1
9
miRNA targets in ECM and membrane receptors 1
10.65 COL1A2 COL3A1 COL5A1 COL5A2 TNXB
10
G-protein signaling_Rap2B regulation pathway 22
10.54 CCN2 COL1A2 COL3A1 COL5A1 COL5A2 FBN1
Sources

GO Terms for Collagen Disease

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Cellular components related to Collagen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.65 COL1A2 COL3A1 COL5A1 COL5A2 FBN1
2 collagen trimer GO:0005581 9.46 COL1A2 COL3A1 COL5A1 COL5A2
3 collagen-containing extracellular matrix GO:0062023 9.43 COL1A2 COL3A1 COL5A1 COL5A2 FBN1 TNXB
4 collagen type V trimer GO:0005588 9.32 COL5A1 COL5A2
5 extracellular matrix GO:0031012 9.17 CCN2 COL1A2 COL3A1 COL5A1 COL5A2 FBN1
6 extracellular region GO:0005576 10.02 CCN2 COL1A2 COL3A1 COL5A1 COL5A2 EDN1
7 extracellular space GO:0005615 10.01 CCN2 COL1A2 COL3A1 COL5A1 COL5A2 EDN1

Biological processes related to Collagen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to amino acid stimulus GO:0071230 9.63 COL1A2 COL3A1 COL5A2
2 blood vessel development GO:0001568 9.61 COL1A2 COL3A1 COL5A1
3 skin development GO:0043588 9.58 COL3A1 COL5A1 COL5A2
4 skeletal system development GO:0001501 9.55 COL1A2 COL3A1 COL5A2 EDN1 FBN1
5 collagen metabolic process GO:0032963 9.48 PLOD1 TNXB
6 supramolecular fiber organization GO:0097435 9.43 B4GALT7 COL3A1 COL5A1
7 extracellular matrix organization GO:0030198 9.43 COL1A2 COL3A1 COL5A1 COL5A2 FBN1 TNXB
8 eye morphogenesis GO:0048592 9.37 COL5A1 COL5A2
9 negative regulation of endodermal cell differentiation GO:1903225 9.32 COL5A1 COL5A2
10 collagen fibril organization GO:0030199 9.1 COL1A2 COL3A1 COL5A1 COL5A2 PLOD1 TNXB

Molecular functions related to Collagen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.62 CCN2 COL5A1 FBN1 TNXB
2 integrin binding GO:0005178 9.55 CCN2 COL3A1 COL5A1 FBN1 TNXB
3 SMAD binding GO:0046332 9.54 COL1A2 COL3A1 COL5A2
4 platelet-derived growth factor binding GO:0048407 9.43 COL1A2 COL3A1 COL5A1
5 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.26 COL1A2 COL3A1 COL5A1 COL5A2
6 extracellular matrix structural constituent GO:0005201 9.1 COL1A2 COL3A1 COL5A1 COL5A2 FBN1 TNXB
7 protein binding GO:0005515 10.31 B4GALT7 CCN2 COL1A2 COL3A1 COL5A1 EDN1
Sources

Sources for Collagen Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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