MCID: CLL015
MIFTS: 42

Collagen Disease

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Collagen Disease

MalaCards integrated aliases for Collagen Disease:

Name: Collagen Disease 12 15
Collagen Diseases 54 43 71
Collagen Disorder 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:854
MeSH 43 D003095
NCIt 49 C27204
SNOMED-CT 67 81573002
UMLS 71 C0009326

Summaries for Collagen Disease

Disease Ontology : 12 A connective tissue disease that characterized by connective tissue disease that has material basis in inheritable defects in collagen.

MalaCards based summary : Collagen Disease, also known as collagen diseases, is related to rheumatic disease and ehlers-danlos syndrome. An important gene associated with Collagen Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways is miRNA targets in ECM and membrane receptors. The drugs Prednisone and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and lung.

Wikipedia : 74 A connective tissue disease (collagenosis) is any disease that has the connective tissues of the body as... more...

Related Diseases for Collagen Disease

Diseases in the Collagen Disease family:

Collagen Type Vi-Related Disorders Type Ii Collagen Disorders

Diseases related to Collagen Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 486)
# Related Disease Score Top Affiliating Genes
1 rheumatic disease 32.9 TRIM21 TOP1 SSB MIR142 ICOSLG H2AC18
2 ehlers-danlos syndrome 32.8 FBN1 COL5A1 COL3A1 COL1A2
3 scleroderma, familial progressive 31.5 TOP1 FBN1 COL1A2 CENPB
4 autoimmune disease 31.2 TRIM21 RPL7 ICOSLG CENPB CCR6
5 idiopathic interstitial pneumonia 31.0 MIR21 MIR142 CCR6
6 systemic lupus erythematosus 30.9 TRIM21 SSB SNRNP70 RPL7 MIR223 MIR21
7 sialadenitis 30.8 TRIM21 SSB ICOSLG CCR6
8 peripheral nervous system disease 30.6 MIR21 MIR142 ICOSLG H2AC18 CCR6
9 iga glomerulonephritis 30.5 ICOSLG CFHR2 CCR6
10 keratoconjunctivitis sicca 30.5 TRIM21 SSB CCR6
11 blood coagulation disease 30.5 ICOSLG H2AC18 CFHR2 CCR6
12 systemic scleroderma 30.5 TRIM21 TOP1 SSB SNRNP70 MIRLET7D MIR223
13 raynaud disease 30.5 TRIM21 TOP1 SNRNP70 CENPB
14 ehlers-danlos syndrome, classic type, 1 30.4 COL5A1 COL3A1 COL1A2
15 parasitic helminthiasis infectious disease 30.3 MIR21 ICOSLG H2AC18 CCR6
16 connective tissue disease 30.3 TOP1 SSB SNRNP70 MIRLET7D MIR223 MIR21
17 diffuse scleroderma 30.3 TRIM21 TOP1 SNRNP70 EXOSC10 COL1A2 CENPB
18 xerophthalmia 30.3 TRIM21 SSB CENPB
19 chediak-higashi syndrome 30.2 ICOSLG H2AC18 CCR6
20 mycobacterium tuberculosis 1 30.2 MIR223 MIR21 ICOSLG H2AC18 CCR6
21 crest syndrome 30.2 TOP1 SNRNP70 H2AC18 EXOSC10 CENPB
22 brittle bone disorder 30.2 FBN1 COL5A1 COL3A1 COL1A2
23 marfan syndrome 30.2 FBN1 COL5A1 COL3A1 COL1A2
24 skin disease 30.1 MIR21 MIR142 ICOSLG H2AC18 CCR6
25 pulmonary fibrosis, idiopathic 30.0 MIRLET7D MIR21 MIR142 ICOSLG COL3A1 COL1A2
26 orthostatic intolerance 30.0 FBN1 COL5A1 COL3A1
27 eye disease 30.0 MIR21 MIR142 ICOSLG H2AC18 FBN1 CFHR2
28 telangiectasis 30.0 TRIM21 TOP1 SNRNP70 H2AC18 FBN1 EXOSC10
29 disseminated eosinophilic collagen disease 12.4
30 type ii collagen disorders 12.3
31 alpha-2-deficient collagen disease 12.2
32 pierre robin syndrome associated with collagen disease 12.2
33 hypereosinophilic syndrome 11.5
34 mixed connective tissue disease 11.3
35 bone fragility with contractures, arterial rupture, and deafness 11.1
36 collagenopathy, types ii and xi 11.0
37 conjunctival vascular disease 10.7 TRIM21 TOP1
38 listeriosis 10.7 ICOSLG H2AC18 CCR6
39 coccidiosis 10.7 ICOSLG H2AC18 CCR6
40 larsen-like syndrome 10.7 COL3A1 COL1A2
41 thymus gland disease 10.7 ICOSLG H2AC18 CCR6
42 autoimmune disease of endocrine system 10.7 ICOSLG H2AC18 CCR6
43 thymus cancer 10.7 ICOSLG H2AC18 CCR6
44 diffuse cutaneous systemic sclerosis 10.7 ICOSLG FBN1 CCR6
45 immune-complex glomerulonephritis 10.7 ICOSLG H2AC18 CFHR2
46 esophagitis, eosinophilic, 1 10.7 MIR223 ICOSLG CCR6
47 syndromic x-linked intellectual disability cabezas type 10.7 TOP1 EXOSC10 COL1A2
48 spinal cord disease 10.7 MIR142 ICOSLG H2AC18 CCR6
49 combined t cell and b cell immunodeficiency 10.7 ICOSLG H2AC18 CCR6
50 neuromuscular junction disease 10.7 ICOSLG H2AC18 CCR6

Graphical network of the top 20 diseases related to Collagen Disease:



Diseases related to Collagen Disease

Symptoms & Phenotypes for Collagen Disease

Drugs & Therapeutics for Collagen Disease

Drugs for Collagen Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 135)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
3
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
4
Acetaminophen Approved Phase 4 103-90-2 1983
5
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
6
Abatacept Approved Phase 4 332348-12-6 10237
7
leucovorin Approved Phase 4 58-05-9 6006 143
8
Ribavirin Approved Phase 4 36791-04-5 37542
9
Peginterferon alfa-2a Approved, Investigational Phase 4 198153-51-4 5360545
10
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
11
Lactitol Investigational Phase 4 585-86-4, 585-88-6 493591
12 Vaccines Phase 4
13 Anti-Inflammatory Agents Phase 4
14 Analgesics, Non-Narcotic Phase 4
15 Analgesics Phase 4
16 Anti-Bacterial Agents Phase 4
17 Gentamicins Phase 4
18 Hormone Antagonists Phase 4
19 glucocorticoids Phase 4
20 Hormones Phase 4
21 Antineoplastic Agents, Hormonal Phase 4
22 Hydrocortisone hemisuccinate Phase 4
23 Hydrocortisone-17-butyrate Phase 4
24 Hydrocortisone 17-butyrate 21-propionate Phase 4
25 Antipyretics Phase 4
26 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
27 Immunoglobulins Phase 4
28 Antibodies Phase 4
29 Pharmaceutical Solutions Phase 4
30 Folic Acid Antagonists Phase 4
31 Vitamin B Complex Phase 4
32 Vitamin B9 Phase 4
33 Dermatologic Agents Phase 4
34 Folate Phase 4
35 Immunologic Factors Phase 4
36 Antimetabolites Phase 4
37 Anti-Infective Agents Phase 4
38 Antiviral Agents Phase 4
39 interferons Phase 4
40 Interferon-alpha Phase 4
41 Interferon alpha-2 Phase 4
42
Alendronate Approved Phase 3 121268-17-5, 66376-36-1 2088
43
Etanercept Approved, Investigational Phase 3 185243-69-0
44
Rivaroxaban Approved Phase 3 366789-02-8
45
Cyclobenzaprine Approved Phase 3 303-53-7 2895
46
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
47
Leuprolide Approved, Investigational Phase 3 53714-56-0 3911 657181
48
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
49
Alfacalcidol Approved, Nutraceutical Phase 3 41294-56-8 5282181
50 Anti-Inflammatory Agents, Non-Steroidal Phase 3

Interventional clinical trials:

(show top 50) (show all 148)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
2 A Prospective, Randomised, Uncontrolled, Single-Centre, Post-Market Surveillance Study To Evaluate The Performance Of SmartSet® HV and SmartSet® GHV Bone Cements In Primary Cemented Total Hip Arthroplasty(THA) Completed NCT00872066 Phase 4
3 A Prospective, Randomised, Controlled, Single Centre, Blinded Study of the Wear Characteristics of Two Polyethylene Bearing Surfaces, Enduron vs. Marathon Completed NCT00208442 Phase 4
4 Prospective Cohort Study of the Influence of Age, Underlying Disease and Immunosuppression on Vaccine Responses to Influenza A H1N1/09 Immunization in High-risk Patients. Completed NCT01022905 Phase 4
5 Patient Self-administration of Cortisol for Cortisol-responding Disorders in Men and Women Over the Age of 17, Demonstration of Double-blind Trial Results Completed NCT03558971 Phase 4 Cortisol
6 Acetaminophen for Mood and Memory Changes Associated With Prednisone Therapy Completed NCT00377364 Phase 4 Drug: Acetaminophen, Drug: Placebo
7 Combined Pneumococcal Conjugate and Polysaccharide Vaccination in Inflammatory Rheumatic Disease. Impact of Antirheumatic Treatment on Antibody Response. Active, not recruiting NCT03762824 Phase 4
8 EFFECTS OF ABATACEPT ON THE PROGRESSION TO RHEUMATOID ARTHRITIS IN PATIENTS WITH PALINDROMIC RHEUMATISM (PALABA) Not yet recruiting NCT03669367 Phase 4 Abatacept Injection;hydroxycloroquina
9 Abatacept to Silence Anti-citrullinated Protein Antibody-expressing B Cells in Rheumatoid Arthritis (ASCARA). Not yet recruiting NCT03492658 Phase 4 Abatacept;Methotrexate
10 Prospective, Uncontrolled, Multi-Centre, Post-Marketing Surveillance Study to Evaluate the Long-Term Performance of Summit Tapered Hip in Cementless Total Hip Arthroplasty Terminated NCT00208390 Phase 4
11 Prospective, Uncontrolled, Two-centre, RSA, Post-market Surveillance Study to Evaluate the Stability of the C-Stem™ AMT Femoral Component in Primary Total Hip Arthroplasty. Terminated NCT00872573 Phase 4
12 Uncontrolled Prospective Multi-Centre Post Marketing Surveillance Study to Monitor the Long Term Survivorship of Pinnacle™ Acetabular Cup Prosthesis With a Ceramic-on-ceramic Bearing in Subjects With Aetiologies Requiring a Primary Total Hip Replacement Terminated NCT00872222 Phase 4
13 Prospective Multi-Centre, Uncontrolled, Post Marketing Surveillance Study to Monitor the Long-Term Performance of the DePuy ASR Hip System in Subjects With Suitable Indications for a Primary Resurfacing Hip Arthroplasty Terminated NCT00208377 Phase 4
14 Uncontrolled Prospective Multi-Centre Post Marketing Surveillance Study to Monitor the Long Term Survivorship of Pinnacle Acetabular Cup Prosthesis With a Metal on Metal Bearing in Subjects With Aetiologies Requiring a Primary Total Hip Replacement Terminated NCT00208364 Phase 4
15 Randomised, Controlled, Prospective, Multi-Centre, Post Market Surveillance Study Comparing a Ceramic-on-Metal Bearing and a Metal-on-Metal Bearing in Subjects Requiring Primary Total Hip Arthroplasty for Non-Inflammatory Degenerative Joint Disease Terminated NCT00873444 Phase 4
16 Prospective Single-centre, Uncontrolled, Post Marketing Surveillance Study to Monitor the Long-term Performance of the DePuy ASR™ Hip in Subjects With Suitable Indications for a Primary Resurfacing Hip Arthroplasty Terminated NCT00872794 Phase 4
17 Prospective, International Multi-centre, Uncontrolled, Post Marketing Surveillance Study to Monitor the Long-term Performance of a Large Metal-on-Metal (MoM) Bearing Comprising a DePuy ASR™ Cup in Conjunction With Either a DePuy ASR™ Hip Resurfacing Femoral Component or a DePuy ASR™ XL Head in Subjects With Indications Suitable for Either a Primary Resurfacing Arthroplasty or Primary Total Hip Arthroplasty Terminated NCT00872547 Phase 4
18 Double Filtration Plasmapheresis (DFPP) in Combination With Pegylated Interferon Alfa-2a and Ribavirin for Patients With Chronic Hepatitis C With Genotype 1 and High Viral Load: a Randomized Controlled Trial Terminated NCT00977054 Phase 4 DFPP + Peg-IFN + RBV;Peg-IFN + RBV
19 Uncontrolled Prospective Multi-Centre Post Marketing Surveillance Study to Monitor the Long Term Survivorship of Pinnacle Acetabular Cup System With a Metal on Enduron Polyethylene Bearing in Subjects With Aetiologies Requiring a Primary Total Hip Replacement Withdrawn NCT00208429 Phase 4
20 Prevention of Glucocorticoid-Induced Osteoporosis in Patients With Rheumatic Diseases. The STOP-Study: a Randomized Placebo Controlled Trial With Alendronate Versus Alfacalcidol. Completed NCT00138983 Phase 3 Alendronate versus alfacalcidol (1-alpha OH vitamin D)
21 A Phase 3, Double-Blind, Randomized, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TNX-102 SL Tablets Taken Daily at Bedtime in Patients With Fibromyalgia Completed NCT02436096 Phase 3 TNX-102 SL Tablet, 2.8mg;Placebo SL Tablet
22 Prospective Trial Comparing the Use of Conventional Electric Scalpel and Harmonic Scalpel in Mastectomy Completed NCT01391988 Phase 3
23 DOES ETANERCEPT INFLUENCE TWEAK MODULATION OF INFLAMMATION DURING INFLAMMATORY RHEUMATISMS (PSORIATIC ARTHRITIS AND RHEUMATOID ARTHRITIS)? Completed NCT02164214 Phase 3 etanercept Treatment
24 Medically Ill Patient Assessment of Rivaroxaban Versus Placebo in Reducing Post-Discharge Venous Thrombo-Embolism Risk Completed NCT02111564 Phase 3 Rivaroxaban, 10 mg;Rivaroxaban, 7.5 mg;Placebo
25 Photobiomodulation for Breast Cancer Radiodermatitis Prevention. A Randomized Controlled Trial. Recruiting NCT04059809 Phase 2, Phase 3
26 A Multi-centre, Randomised, Parallel Group, Controlled Study to Compare the Performance of the Future Hip Against Three Currently Used Implants in Total Hip Replacement Terminated NCT00208468 Phase 3
27 Clinical and Radiographic Evaluation to Compare a Polished and Non-polished Collared Stem and a Polished and Non Polished Collarless Stem in Primary Total Hip Replacement Terminated NCT00208351 Phase 3
28 GnRH-a for Ovarian Protection During CYC Therapy for Rheumatic Diseases Terminated NCT01257802 Phase 3 depot leuprolide acetate 3.75 mg;Placebo
29 A Phase 3, Double-Blind, Randomized, Multicenter, Placebo-Controlled Study To Evaluate The EFFIcacy and Safety of TNX-102 SL Tablets Taken Daily At Bedtime In Patients With FibRoMyalgia Terminated NCT02829814 Phase 3 TNX-102 SL Tablet, 2.8 mg;Placebo SL Tablet
30 Efficacy and Safety of Vaccination Against Influenza H1N1 in Patients With Rheumatoid Arthritis, Systemic Lupus Erythematosus, Psoriatic Arthritis and Ankylosing Spondylitis Treated With Immunomodulatory Drugs Unknown status NCT01006681 Phase 2
31 Intraarticular Application of Opioids Versus Glucocorticosteroids Versus Placebo in Rheumatoid Arthritis Unknown status NCT00244153 Phase 1, Phase 2 intraarticular morphine;intraarticular dexamethasone
32 Immunogenicity and Efficacy of High-dose Trivalent Inactivated Seasonal Influenza Vaccine (Fluzone High Dose) in Immunocompromised Children and Young Adults. Completed NCT01685372 Phase 2
33 Articular Cartilage Regeneration in Gonarthrosis Grade II and III by Articular Infiltration of Xcel-m-condro-alpha. Completed NCT01227694 Phase 1, Phase 2
34 Improving Vocational Outcomes in Arthritis Completed NCT00000407 Phase 2
35 A Randomized, Double-Blind, Placebo-Controlled, Titration-to-Effect Study of Orally Administered CR845 in Patients With Osteoarthritis of the Hip or Knee Completed NCT02944448 Phase 2 CR845 tablet 1 mg;CR845 tablet 2.5 mg;CR845 tablet 5 mg;Placebo tablet
36 Booster Vaccine Strategy to Improve Serologic Responses to Influenza Vaccination in Children With Rheumatic Diseases and Inflammatory Bowel Disease Who Are Receiving Immunosuppressive Therapies Recruiting NCT03277703 Phase 2
37 Treatment of Refractory Hemochromatosis Rheumatism by Anakinra: a Preliminary Phase II Study Terminated NCT02263638 Phase 2 Anakinra
38 An Open, Dose Escalation, Single Dose Study to Assess Tolerance and Pharmacokinetics of T0001 in Healthy Adult Chinese Volunteers Completed NCT02291471 Phase 1 T0001,10mg;T0001,20mg;T0001,35mg;T0001,50mg;T0001,65mg;T0001,75mg
39 Safety/Efficacy of Intra-articular Administration of Autologous Tolerogenic Dendritic Cells for Treatment of Patients With Rheumatoid Arthritis Completed NCT03337165 Phase 1
40 Pilot Study Characterizing Aerobic Exercise in Women With Systemic Lupus Erythematosus (Exercise SLE Pilot) Recruiting NCT03186794 Phase 1
41 The Effect of Puerarin Tablets in Treating Metabolism Syndrome in Patients With Chronic Rheumatic Diseases Unknown status NCT02219191 puerarin tablet 50 mg;Atorvastatin tablet 20 mg
42 41.8 Degree Centigrade Whole Body Hyperthermia for the Treatment of Rheumatoid Diseases Unknown status NCT00000106
43 Health Related Quality of Life After a Self-promoting Problem-based Learning Program for People With Rheumatic Diseases: a Randomized Controlled Trial Unknown status NCT00803491
44 Local Analgesia in Knee- and Hipatroplastic Surgery in Patients With Rheumatic Disease: Extra- vs. Intracapsulare Position of Catheter Unknown status NCT01050738
45 Prediction of Methotrexate Response - A Pilot Study Unknown status NCT01726959
46 Identification of Epigenetic Biomarkers for Early Detection of Rheumatic Disease Unknown status NCT02742337
47 Evaluation of the Usefulness of Interferon-γ Release Assays and Tuberculin Skin Test for Detection of Latent Mycobacterium Tuberculosis Infection in Korean Patients With Rheumatic Diseases Unknown status NCT01685905
48 Evaluation of an Outpatient Pharmacy Clinical Services Program on Adherence and Clinical Outcomes Among Patients With Rheumatic Diseases Unknown status NCT03024307
49 Effect of Remote Ischemic Perconditioning on Acute Kidney Injury in Adult Valve Replace Unknown status NCT01476969
50 Nurse-led Clinic for Patients With Rheumatic Diseases and Biological Treatment:a Randomized Controlled Trial Comparing Nurse-led Clinic Versus Rheumatologist Clinic Unknown status NCT01071447

Search NIH Clinical Center for Collagen Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


prednisolone
prednisolone acetate
PREDNISOLONE ACETATE PWDR
PREDNISOLONE PWDR
Prednisolone sodium phosphate
prednisolone tebutate
Prednisone
PREDNISONE PWDR

Cochrane evidence based reviews: collagen diseases

Genetic Tests for Collagen Disease

Anatomical Context for Collagen Disease

MalaCards organs/tissues related to Collagen Disease:

40
Bone, Skin, Lung, Testes, Kidney, Liver, T Cells

Publications for Collagen Disease

Articles related to Collagen Disease:

(show top 50) (show all 2654)
# Title Authors PMID Year
1
Takotsubo cardiomyopathy complicated by cardiac tamponade due to non-hemorrhagic pericardial effusion: a case report. 61
32028901 2020
2
Retinal vascular inflammatory and occlusive changes in infectious and non-infectious uveitis. 61
32016664 2020
3
Characteristics of shared decision making in Romania from the patient perspective: A cross-sectional multicentric study. 61
31407420 2019
4
Characteristics and Risk Factors Associated With Diagnosed and Undiagnosed Symptomatic Dry Eye Using a Smartphone Application. 61
31774457 2019
5
Clinical manifestations of skin, lung and muscle diseases in dermatomyositis positive for anti-aminoacyl tRNA synthetase antibodies. 61
31418479 2019
6
Posterior reversible encephalopathy syndrome: A review with emphasis on neuroimaging characteristics. 61
31349066 2019
7
Uterine cervical ulceration caused by group C streptococcal infection during pregnancy: A case report. 61
31074169 2019
8
A case of spontaneous coronary artery dissection with early de novo recurrence. 61
31320943 2019
9
Romanian version of SDM-Q-9 validation in Internal Medicine and Cardiology setting: a multicentric cross-sectional study. 61
30721145 2019
10
Chronic intestinal pseudo-obstruction with pneumatosis cystoides intestinalis in a patient with systemic sclerosis: A case report. 61
31045831 2019
11
Rheumatoid arthritis-like active synovitis with T-cell activation in a case of idiopathic multicentric Castleman disease: A case report. 61
31045763 2019
12
Open staged repair of splenic and extensive superior mesenteric artery aneurysms. 61
30292603 2019
13
Impact of Therapeutic Angiogenesis Using Autologous Bone Marrow-Derived Mononuclear Cells Implantation in Critical Limb Ischemia With Scleroderma - Subanalysis of the Long-Term Clinical Outcomes Survey. 61
30726805 2019
14
Delayed diagnosis of postcardiac injury syndrome. 61
30824470 2019
15
High Mobility Group Box-1 (HMGB1): A Potential Target in Therapeutics. 61
31215389 2019
16
Systemic diseases and disorders. 61
31604558 2019
17
[Acute myelitis associated with anti-neutral glycolipid antibody]. 61
30606995 2019
18
A case of overlap syndrome (scleroderma and polymyositis) associated with the development of sudden chest pain due to myocardial damage. 61
31723102 2019
19
Role of Deleterious Rare Alleles for Acute-Onset Diffuse Interstitial Lung Disease in Collagen Diseases. 61
31391785 2019
20
Ultrasound and color Doppler applications in chronic kidney disease. 61
30191413 2018
21
Dry skin manifestations in Sjögren syndrome and atopic dermatitis related to aberrant sudomotor function in inflammatory allergic skin diseases. 61
30104151 2018
22
Efficacy and safety of minodronic acid hydrate in patients with steroid-induced osteoporosis. 61
26929019 2018
23
Pathogenic roles of B lymphocytes in systemic sclerosis. 61
29307688 2018
24
Long-Term Clinical Outcomes Survey of Bone Marrow-Derived Cell Therapy in Critical Limb Ischemia in Japan. 61
29386474 2018
25
Five-decade-delayed closed flexor tendon rupture due to Galeazzi dislocation fracture associated with Behçet syndrome: A case report. 61
29913431 2018
26
The Complement System Is Critical in Maintaining Retinal Integrity during Aging. 61
29497373 2018
27
Serum Soluble Vascular Cell Adhesion Molecule-1 Overexpression Is a Disease Marker in Patients with First-Time Diagnosed Antinuclear Antibodies: A Prospective, Observational Pilot Study. 61
29487871 2018
28
Immune reconstitution inflammatory syndrome in non-HIV immunosuppressed patients. 61
28944502 2018
29
Preventive and promotive effects of habitual hot spa-bathing on the elderly in Japan. 61
29317745 2018
30
Pseudolymphoma with atrophic parenchyma of the liver: Report of a case. 61
30005366 2018
31
Acute hepatitis E in a renal transplantation recipient: a case report. 61
29670408 2018
32
[Rapid exacerbation of thrombotic microangiopathy accompanied by electrocardiogram abnormality leading to death]. 61
30078800 2018
33
[An anti-RNP antibody-positive case of aseptic meningitis induced by non-steroidal anti-inflammatory drugs in a young woman]. 61
29269694 2018
34
Analysis of gastrointestinal virus infection in immunocompromised hosts by multiplex virus PCR assay. 61
31294212 2018
35
Impact of Preoperative Patient Characteristics and Flow Rate on Failure, Early Complications, and Voiding Dysfunction After a Transobturator Tape Procedure: A Multicentre Study. 61
29298467 2017
36
Surgical management of nonbacterial thrombotic endocarditis in malignancy. 61
28477331 2017
37
Bone Formation Parameters of the Biopsied Ilium Differ between Subtrochanteric and Diaphyseal Atypical Femoral Fractures in Bisphosphonate-Treated Patients. 61
29212985 2017
38
Revealing Accessibility of Cryptic Protein Binding Sites within the Functional Collagen Fibril. 61
29104255 2017
39
Unique circumferential peripheral keratitis in relapsing polychondritis: A case report. 61
29019876 2017
40
Chiari Type 1 Malformation-induced Intracranial Hypertension with Diffuse Brain Edema Treated with Foramen Magnum Decompression: A Case Report. 61
29018653 2017
41
Nonimmediate allergic reactions induced by Mesna. 61
29264044 2017
42
Acute Compartment Syndrome Which Causes Rhabdomyolysis by Carbon Monoxide Poisoning and Sciatic Nerve Injury Associated with It: A Case Report. 61
28955688 2017
43
Genetic identification of a common collagen disease in puerto ricans via identity-by-descent mapping in a health system. 61
28895531 2017
44
Elevated Serum Anti-GM-CSF Antibodies before the Onset of Autoimmune Pulmonary Alveolar Proteinosis in a Patient with Sarcoidosis and Systemic Sclerosis. 61
28966213 2017
45
Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model. 61
28809824 2017
46
[Complications and postoperative therapeutic strategies in cross-linking]. 61
28540578 2017
47
Growth hormone therapy for a patient with idiopathic Fanconi syndrome and growth hormone deficiency. 61
28509131 2017
48
Ascites in a patient with episodic angio-oedema and eosinophilia: thinking outside the box. 61
28432171 2017
49
Livedoid vasculopathy and popliteal artery occlusion in a patient with protein S deficiency. 61
27774697 2017
50
Circulating antibodies to α-enolase and phospholipase A2 receptor and composition of glomerular deposits in Japanese patients with primary or secondary membranous nephropathy. 61
26830547 2017

Variations for Collagen Disease

Expression for Collagen Disease

Search GEO for disease gene expression data for Collagen Disease.

Pathways for Collagen Disease

Pathways related to Collagen Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.43 COL5A1 COL3A1 COL1A2

GO Terms for Collagen Disease

Cellular components related to Collagen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.62 FBN1 COL5A1 COL3A1 COL1A2
2 extracellular matrix GO:0031012 9.46 FBN1 COL5A1 COL3A1 COL1A2
3 collagen trimer GO:0005581 9.43 COL5A1 COL3A1 COL1A2
4 collagen-containing extracellular matrix GO:0062023 9.35 NPPA FBN1 COL5A1 COL3A1 COL1A2
5 extracellular space GO:0005615 9.28 NPPA MIRLET7D MIR223 MIR21 MIR142 FBN1

Biological processes related to Collagen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.62 FBN1 COL5A1 COL3A1 COL1A2
2 transforming growth factor beta receptor signaling pathway GO:0007179 9.58 MIR21 COL3A1 COL1A2
3 collagen metabolic process GO:0032963 9.43 MIR21 COL1A2
4 supramolecular fiber organization GO:0097435 9.37 COL5A1 COL3A1
5 blood vessel development GO:0001568 9.33 COL5A1 COL3A1 COL1A2
6 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1902514 9.26 NPPA MIR21
7 collagen fibril organization GO:0030199 9.13 COL5A1 COL3A1 COL1A2
8 positive regulation of potassium ion export across plasma membrane GO:1903766 8.62 NPPA MIR21

Molecular functions related to Collagen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.33 COL5A1 COL3A1 COL1A2
2 extracellular matrix structural constituent GO:0005201 9.26 FBN1 COL5A1 COL3A1 COL1A2
3 platelet-derived growth factor binding GO:0048407 8.8 COL5A1 COL3A1 COL1A2

Sources for Collagen Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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