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MCID: CLL021
MIFTS: 45

Collagenous Colitis

Categories: Gastrointestinal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Collagenous Colitis

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MalaCards integrated aliases for Collagenous Colitis:

Name: Collagenous Colitis 12 76 53 55 15
Colitis, Collagenous 44 73
Microscopic Colitis, Collagenous Type 53

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060183
ICD10 33 K52.831
MeSH 44 D046729
NCIt 50 C27021
SNOMED-CT 68 19311003
UMLS 73 C0238067
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Summaries for Collagenous Colitis

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NIH Rare Diseases : 53 Collagenous colitis is a type of inflammatory bowel disease that affects the colon. It is a form of microscopic colitis, which causes chronic diarrhea. It typically occurs in middle-aged adults, is more common in females than in males, and has rarely been reported in children. In all forms of microscopic colitis, the colon appears normal or almost normal on colonoscopy, but the inflammation is visible when a biopsy of the colon is examined under a microscope (hence its name). Signs and symptoms include chronic, watery, non-bloody diarrhea that may begin suddenly or worsen over time. People with this disease usually have between four and nine watery bowel movements per day, but in rare cases may have more than fifteen. Various other symptoms relating to the gastrointestinal system or other body symptoms may also be present. The cause of collagenous colitis is not known but it is thought to be multifactorial. This means that both genetic and environmental factors may interact to cause a person to develop the disease. The extent to which genes play a role is unclear, but familial cases have been described. Certain medications, such as NSAIDS and proton pump inhibitors, have been reported to cause or trigger the disease in some people. However, strong evidence directly linking these medications to the disease is still lacking. The main goal of treatment is to lessen the number of bowel movements per day and improve quality of life. Treatment depends on the symptoms and severity in each person and may involve avoiding or discontinuing medications that may be associated with the disease, taking anti-diarrheal medications, budesonide, or other medications. Surgery to remove all or part of the colon may be needed in severe cases that do not respond to other treatments. In some cases, diarrhea resolves within weeks (with or without treatment), but relapses are common.

MalaCards based summary : Collagenous Colitis, also known as colitis, collagenous, is related to lymphocytic colitis and proctitis. An important gene associated with Collagenous Colitis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Innate Immune System and Colorectal Cancer Metastasis. The drugs Budesonide and Rifaximin have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and t cells, and related phenotype is muscle.

Disease Ontology : 12 A colitis characterized by a distinctive thickening of the subepithelial collagen table.

Wikipedia : 76 Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak... more...

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Related Diseases for Collagenous Colitis

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Diseases related to Collagenous Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
# Related Disease Score Top Affiliating Genes
1 lymphocytic colitis 32.5 CHGA MMP9
2 proctitis 29.4 EPX MPO RNASE3
3 food allergy 29.4 EPX RNASE3
4 inflammatory bowel disease 29.2 CHGA EPX MMP1 MPO NOS2
5 microscopic colitis 11.5
6 collagenous gastritis 11.5
7 colitis 11.0
8 ulcerative colitis 10.3
9 arthritis 10.3
10 diarrhea 10.2
11 maxillary sinusitis 10.2 MPO RNASE3
12 hemorrhoid 10.2 MMP9 NOS2
13 autoimmune inner ear disease 10.2 MMP9 MPO
14 inner ear disease 10.2 MMP9 MPO
15 chronic maxillary sinusitis 10.2 MPO RNASE3
16 vernal keratoconjunctivitis 10.2 MMP9 RNASE3
17 henoch-schoenlein purpura 10.2 MPO RNASE3
18 churg-strauss syndrome 10.2 MPO RNASE3
19 mycetoma 10.2 MMP9 NOS2
20 periodontosis 10.2 MMP9 MPO
21 pelvic inflammatory disease 10.1 MMP9 MPO
22 protein-losing enteropathy 10.1
23 spastic entropion 10.1 MMP1 MMP9
24 chronic actinic dermatitis 10.1 MMP1 MMP9
25 chromoblastomycosis 10.1 MMP1 MMP9
26 light chain deposition disease 10.1 MMP1 MMP9
27 adult astrocytic tumour 10.1 MMP1 MMP9
28 signet ring cell adenocarcinoma 10.1 CHGA COL14A1
29 intracranial primitive neuroectodermal tumor 10.1 CHGA SCG2
30 crohn's disease 10.1
31 adrenal medulla cancer 10.1 CHGA SCG2
32 chronic venous insufficiency 10.1 MMP1 MMP9
33 venous insufficiency 10.1 MMP1 MMP9
34 appendicitis 10.1 MMP9 MPO
35 respiratory system disease 10.1 MMP9 MPO RNASE3
36 pelvic organ prolapse 10.1 MMP1 MMP9
37 hypertensive heart disease 10.1 MMP1 MMP9
38 celiac disease 1 10.1
39 crohn's colitis 10.1
40 lung disease 10.1 MMP9 MPO RNASE3
41 glucagonoma 10.0 CHGA CHGB
42 conjunctivitis 10.0 EPX RNASE3
43 aortic aneurysm, familial thoracic 1 10.0 MMP1 MMP9
44 carcinoid tumors, intestinal 10.0 CHGA CHGB
45 eosinophilic granuloma 10.0 EPX RNASE3
46 preterm premature rupture of the membranes 10.0 MMP1 MMP9
47 inflammatory bowel disease 4 10.0 EPX RNASE3
48 pneumothorax 10.0 MMP1 MMP9
49 mixed ductal-endocrine carcinoma 10.0 CHGA CHGB
50 eosinophil peroxidase deficiency 10.0 EPX MPO

Graphical network of the top 20 diseases related to Collagenous Colitis:



Diseases related to Collagenous Colitis
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Symptoms & Phenotypes for Collagenous Colitis

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MGI Mouse Phenotypes related to Collagenous Colitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.02 CHGA COL14A1 MMP9 MPO NOS2
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Drugs & Therapeutics for Collagenous Colitis

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Drugs for Collagenous Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 3,Not Applicable 51333-22-3 63006 5281004
2
Rifaximin Approved, Investigational Phase 3 80621-81-4 6436173
3 Hormone Antagonists Phase 3,Not Applicable
4 Anti-Inflammatory Agents Phase 3,Not Applicable
5 Autonomic Agents Phase 3,Not Applicable
6 Peripheral Nervous System Agents Phase 3,Not Applicable
7 Hormones Phase 3,Not Applicable
8 Respiratory System Agents Phase 3,Not Applicable
9 glucocorticoids Phase 3,Not Applicable
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Not Applicable
11 Anti-Asthmatic Agents Phase 3,Not Applicable
12 Bronchodilator Agents Phase 3,Not Applicable
13 Mesalamine Phase 3 89-57-6
14 Anti-Inflammatory Agents, Non-Steroidal Phase 3
15 Analgesics Phase 3
16 Antirheumatic Agents Phase 3
17 Analgesics, Non-Narcotic Phase 3
18 Rifamycins Phase 3
19 Anti-Bacterial Agents Phase 3
20 Nucleic Acid Synthesis Inhibitors Phase 3
21 rifamycin SV Phase 3
22 Anti-Infective Agents Phase 3
23 Gastrointestinal Agents Phase 3,Not Applicable
24 Pharmaceutical Solutions Not Applicable
25 Cola Not Applicable
26 Anti-Ulcer Agents Not Applicable
27 Antacids Not Applicable
28
Bismuth Not Applicable 7440-69-9 16682734 105143

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long-Term Treatment of Collagenous Colitis With Budesonide Unknown status NCT00139165 Phase 3 Budesonide
2 Budesonide for Maintenance Treatment of Collagenous Colitis Completed NCT00180076 Phase 3 Budesonide
3 Budesonide Capsules vs. Mesalazine Granules vs. Placebo in Collagenous Colitis Completed NCT00450086 Phase 3 Budesonide;Mesalazine;Placebo
4 SOIBD Collagenous Colitis Maintenance Study Completed NCT01278082 Phase 3 Budesonide;Placebo
5 Rifaximin-treatment of Collagenous Colitis Not yet recruiting NCT03658993 Phase 3 Rifaximin 550 MG
6 Usefulness of Chromoendoscopy in Diagnosing Microscopic Colitis Unknown status NCT01504048 Not Applicable
7 Case-Control Study to Identify Risk Factors for Microscopic Colitis Completed NCT01928667
8 Treatment of Microscopic Colitis Terminated NCT00184171 Not Applicable Budesonide;Bismuth;Fiber

Search NIH Clinical Center for Collagenous Colitis

Cochrane evidence based reviews: colitis, collagenous

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Genetic Tests for Collagenous Colitis

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Anatomical Context for Collagenous Colitis

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MalaCards organs/tissues related to Collagenous Colitis:

41
Colon, Small Intestine, T Cells, Heart, Lung, Bone, Spinal Cord
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Publications for Collagenous Colitis

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Articles related to Collagenous Colitis:

(show top 50) (show all 464)
# Title Authors Year
1
Evaluation by MR Enterocolonography of Lansoprazole-induced Collagenous Colitis Accompanied with Protein-losing Enteropathy. ( 29033425 )
2018
2
Vedolizumab as a Novel Treatment for Refractory Collagenous Colitis: A Case Report. ( 29610507 )
2018
3
Moyamoya complicated by thrombotic cerebrovascular accident in a Caucasian woman with collagenous colitis. ( 30094527 )
2018
4
Vedolizumab for refractory collagenous colitis: Another piece of the puzzle. ( 30115575 )
2018
5
Interventions for treating collagenous colitis. ( 29127772 )
2017
6
Proton pump inhibitor induced collagen expression in colonocytes is associated with collagenous colitis. ( 28321159 )
2017
7
Acute onset collagenous colitis associated with protein-losing enteropathy. ( 29264009 )
2017
8
Magnifying image-enhanced endoscopy for collagenous colitis. ( 29250581 )
2017
9
Magnifying advanced endoscopy in collagenous colitis: now you see? ( 29250582 )
2017
10
A case of collagenous colitis associated with novel oral anticoagulants use. ( 28260714 )
2017
11
Collagenous colitis presenting with skip lesions mimicking Crohn's disease and complicated by intestinal obstruction. ( 28682012 )
2017
12
Spontaneous Tear after Insufflation: A Unique Finding of Collagenous Colitis. ( 28864270 )
2017
13
Macroscopic findings in collagenous colitis: a multi-center, retrospective, observational cohort study. ( 28469361 )
2017
14
Collagenous colitis: Requirement for high-dose budesonide as maintenance treatment. ( 28457904 )
2017
15
Clinical and immunologic effects of faecal microbiota transplantation in a patient with collagenous colitis. ( 28275312 )
2017
16
Collagenous Colitis Refractory to Budesonide: is the Upper Gastrointestinal Tract Involved? ( 27557639 )
2017
17
Anti-PD1-induced collagenous colitis in a melanoma patient. ( 26990271 )
2016
18
Elevated fecal levels of eosinophil granule proteins predict collagenous colitis in patients referred to colonoscopy due to chronic non-bloody diarrhea. ( 26854205 )
2016
19
Pseudomembranes Carpet the Right Colon as a Result of Collagenous Colitis. ( 27725290 )
2016
20
Comparison of Clinical Features, Treatment and Outcomes of Collagenous Sprue, Celiac Disease and Collagenous Colitis. ( 27620860 )
2016
21
Pseudomembranous Collagenous Colitis: A Case of Not-so-Microscopic Colitis. ( 28119938 )
2016
22
Tofacitinib Response in Juvenile Idiopathic Arthritis (JIA) and Collagenous Colitis. ( 27870773 )
2016
23
Smoking Status Influences Clinical Outcome in Collagenous Colitis. ( 26721941 )
2016
24
Spontaneous colonic perforation: a rare complication of collagenous colitis. ( 27178398 )
2016
25
Automated image analysis in the study of collagenous colitis. ( 27114713 )
2016
26
Optimal management of collagenous colitis: a review. ( 26929656 )
2016
27
Collagenous colitis and Crohn's disease: Guilty or innocent bystander? ( 27474197 )
2016
28
Letter: oral low-dose methotrexate for collagenous colitis. ( 27250588 )
2016
29
Collagenous colitis presenting as spontaneous perforation in an 80A year old woman: Report of a Case. ( 27716080 )
2016
30
Letter: oral low-dose methotrexate for collagenous colitis - authors' reply. ( 27250589 )
2016
31
Immunological Differences between Lymphocytic and Collagenous Colitis. ( 26928959 )
2016
32
Collagenous Colitis Associated with Protein-losing Enteropathy. ( 26568022 )
2015
33
Dense genotyping of immune-related loci identifies HLA variants associated with increased risk of collagenous colitis. ( 26525574 )
2015
34
Fecal stream diversion and mucosal cytokine levels in collagenous colitis: A case report. ( 26019474 )
2015
35
Severe acute kidney injury as a complication of collagenous colitis. ( 26561416 )
2015
36
P171. Smoking is associated with watery diarrhea and decreased likelihood to achieve clinical remission in collagenous colitis. ( 25717636 )
2015
37
Microscopic (collagenous) colitis in a patient with a heart transplant. ( 26115392 )
2015
38
Increased Production of Lysozyme Associated with Bacterial Proliferation in Barrett's Esophagitis, Chronic Gastritis, Gluten-induced Atrophic Duodenitis (Celiac Disease), Lymphocytic Colitis, Collagenous Colitis, Ulcerative Colitis and Crohn's Colitis. ( 26637845 )
2015
39
DOP082. Genome-wide association identifies multiple collagenous colitis susceptibility loci. ( 25718298 )
2015
40
Collagenous Colitis Associated with Rabeprazole in a Peritoneal Dialysis Patient. ( 26450480 )
2015
41
Collagenous colitis with mucosal ulcerations in a patient without nonsteroidal anti-inflammatory drug or lansoprazole use. ( 26130218 )
2015
42
Pseudomembranous variant of collagenous colitis. ( 26508688 )
2015
43
Mucosal tears and colonic perforation in a patient with collagenous colitis. ( 24523187 )
2014
44
Acute onset collagenous colitis with unique endoscopic findings. ( 25610672 )
2014
45
O-018a88genome-wide association identifies multiple collagenous colitis susceptibility Loci. ( 25407172 )
2014
46
Efficacy of budesonide in collagenous colitis Evaluation of: Miehlke S, Madisch A, Kupcinskas L, et al. Budesonide is more effective than mesalamine or placebo in short-term treatment of collagenous colitis. Gastroenterology 2014;146(5):1222-1230 e1222. ( 25164577 )
2014
47
Budesonide is more effective than mesalamine or placebo in short-term treatment of collagenous colitis. ( 24440672 )
2014
48
Low-dose budesonide for maintenance of clinical remission in collagenous colitis: a randomised, placebo-controlled, 12-month trial. ( 25425655 )
2014
49
Collagenous colitis during treatment with fumaric acid esters. ( 25482705 )
2014
50
Collagenous colitis in systemic sclerosis: an overlooked and treatable complication. ( 25036565 )
2014
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Variations for Collagenous Colitis

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Expression for Collagenous Colitis

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Search GEO for disease gene expression data for Collagenous Colitis.
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Pathways for Collagenous Colitis

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Pathways related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.54 CHGA EPX MMP1 MMP9 MPO NOS2
2
Colorectal Cancer Metastasis 64
11.65 MMP1 MMP9 NOS2
3
Interleukin-4 and 13 signaling 66
11.19 MMP1 MMP9 NOS2
4
Hepatitis C and Hepatocellular Carcinoma 1
11.16 MMP1 NOS2
5
amb2 Integrin signaling 1
11.11 MMP9 MPO
6
Cell adhesion_Cell-matrix glycoconjugates 22
10.96 MMP1 MMP9
7
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
10.85 MMP1 MMP9
8
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 10.6 MMP1 MMP9 NOS2
9
Syndecan-1-mediated signaling events 1
10.39 MMP1 MMP9
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GO Terms for Collagenous Colitis

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Cellular components related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 CHGA CHGB COL14A1 EPX MMP9 MPO
2 extracellular matrix GO:0031012 9.5 COL14A1 MMP1 MMP9
3 secretory granule GO:0030141 9.46 CHGA CHGB MPO SCG2
4 endoplasmic reticulum lumen GO:0005788 9.43 CHGB COL14A1 SCG2
5 extracellular region GO:0005576 9.28 CHGA CHGB COL14A1 EPX MMP1 MMP9

Biological processes related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.63 MMP1 MMP9 NOS2
2 cellular protein metabolic process GO:0044267 9.58 CHGB MMP1 SCG2
3 antimicrobial humoral response GO:0019730 9.48 CHGA RNASE3
4 neutrophil degranulation GO:0043312 9.46 EPX MMP9 MPO RNASE3
5 collagen catabolic process GO:0030574 9.43 MMP1 MMP9
6 defense response to fungus GO:0050832 9.37 CHGA MPO
7 hydrogen peroxide catabolic process GO:0042744 9.32 EPX MPO
8 innate immune response in mucosa GO:0002227 9.26 NOS2 RNASE3
9 defense response to Gram-negative bacterium GO:0050829 9.13 CHGA NOS2 RNASE3
10 defense response to bacterium GO:0042742 9.02 CHGA EPX MPO NOS2 RNASE3

Molecular functions related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 8.96 EPX MPO
2 heme binding GO:0020037 8.8 EPX MPO NOS2
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Sources for Collagenous Colitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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