Collagenous Colitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CLL021 MIFTS: 43	Collagenous Colitis Categories: Rare diseases, Gastrointestinal diseases
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Aliases & Classifications for Collagenous Colitis

MalaCards integrated aliases for Collagenous Colitis:

Name: Collagenous Colitis ¹² ⁷⁶ ⁵³ ⁵⁵ ¹⁵

Colitis, Collagenous ⁴⁴ ⁷³

Microscopic Colitis, Collagenous Type ⁵³

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060183

ICD10 ³³ K52.89

MeSH ⁴⁴ D046729

NCIt ⁵⁰ C27021

SNOMED-CT ⁶⁸ 19311003

UMLS ⁷³ C0238067

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Summaries for Collagenous Colitis

NIH Rare Diseases : ⁵³ Collagenous colitis is a type of inflammatory bowel disease that affects the colon. It is a form of microscopic colitis, which means that the inflammation is only visible when a biopsy is examined under a microscope; the inflammation cannot be seen or diagnosed from colonoscopy or sigmoidoscopy. Signs and symptoms may be ongoing or intermittent and may include chronic, watery, non-bloody diarrhea and abdominal pain or cramps. The exact underlying cause is unknown but may relate to a bacteria, a virus, an autoimmune response, and/or a genetic predisposition. Treatment for collagenous colitis varies depending on the symptoms and severity in each individual. In some cases, the condition resolves on its own.

MalaCards based summary : Collagenous Colitis, also known as colitis, collagenous, is related to lymphocytic colitis and proctitis. An important gene associated with Collagenous Colitis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Innate Immune System and Hepatitis C and Hepatocellular Carcinoma. The drugs Budesonide and Anti-Asthmatic Agents have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : ¹² A colitis characterized by a distinctive thickening of the subepithelial collagen table.

Wikipedia : ⁷⁶ Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak... more...

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Related Diseases for Collagenous Colitis

Diseases related to Collagenous Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)

#	Related Disease	Score	Top Affiliating Genes
1	lymphocytic colitis	32.3	CD79A CHGA
2	proctitis	29.0	EPX MPO RNASE3
3	food allergy	28.5	EPX RNASE3
4	inflammatory bowel disease	27.7	CHGA EPX MMP1 MPO NOS2
5	microscopic colitis	11.3
6	collagenous gastritis	11.3
7	colitis	10.9
8	churg-strauss syndrome	10.5	MPO RNASE3
9	intracranial primitive neuroectodermal tumor	10.4	CHGA SCG2
10	internal hemorrhoid	10.4	MMP1 NOS2
11	chronic interstitial cystitis	10.4	CD79A RNASE3
12	anisakiasis	10.4	CD79A RNASE3
13	cow milk allergy	10.3	CD79A RNASE3
14	glucagonoma	10.3	CHGA CHGB
15	autoinflammation, lipodystrophy, and dermatosis syndrome	10.3	MPO NOS2 RNASE3
16	monoclonal paraproteinemia	10.3	CD79A MPO
17	carcinoid tumors, intestinal	10.3	CHGA CHGB
18	gastrointestinal allergy	10.3	CD79A RNASE3
19	odontogenic myxoma	10.3	COL14A1 MMP1
20	mucositis	10.3
21	rapidly progressive glomerulonephritis	10.3	CD79A MPO
22	hypersensitivity vasculitis	10.3	CD79A MPO
23	goodpasture syndrome	10.3	CD79A MPO
24	acute proliferative glomerulonephritis	10.3	CD79A MPO
25	bronchopneumonia	10.2	CD79A MPO
26	conjunctival disease	10.2	CD79A RNASE3
27	hypersensitivity reaction type iii disease	10.2	CD79A MPO
28	vulvitis	10.2	CD79A MPO
29	mixed ductal-endocrine carcinoma	10.2	CHGA CHGB
30	periodontosis	10.2	CD79A MPO
31	milk allergy	10.2	CD79A RNASE3
32	ulcerative stomatitis	10.2	CD79A MPO
33	pulmonary hemosiderosis	10.2	CD79A MPO
34	ulcerative colitis	10.2
35	arthritis	10.2
36	eosinophilic granuloma	10.1	EPX RNASE3
37	ocular cicatricial pemphigoid	10.1	CD79A RNASE3
38	diarrhea	10.1
39	inflammatory bowel disease 4	10.1	EPX RNASE3
40	conjunctival nevus	10.1	EPX RNASE3
41	eosinophilic gastroenteritis	10.1	EPX RNASE3
42	nose disease	10.1	CD79A RNASE3
43	eosinophil peroxidase deficiency	10.1	EPX MPO
44	pulmonary disease, chronic obstructive	10.1	MMP1 MPO RNASE3
45	parasitic helminthiasis infectious disease	10.1	CD79A RNASE3
46	chronic rhinitis	10.0	EPX MPO
47	urinary schistosomiasis	10.0	EPX RNASE3
48	protein-losing enteropathy	10.0
49	upper respiratory tract disease	10.0	CD79A RNASE3
50	maxillary sinusitis	10.0	CD79A MPO RNASE3

Graphical network of the top 20 diseases related to Collagenous Colitis:

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Symptoms & Phenotypes for Collagenous Colitis

GenomeRNAi Phenotypes related to Collagenous Colitis according to GeneCards Suite gene sharing:

²⁶ (show all 19)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-100	9.66	MPO
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-11	9.66	CD79A
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-116	9.66	CHGA
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-123	9.66	CHGA
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-126	9.66	MPO
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-157	9.66	MPO
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-174	9.66	CHGA
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-176	9.66	CHGA MPO
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	9.66	CD79A
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-182	9.66	CHGA
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-186	9.66	MPO
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-215	9.66	CHGA
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-29	9.66	MPO
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-36	9.66	MPO
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-57	9.66	MPO
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	9.66	CD79A
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-7	9.66	MPO
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-70	9.66	MPO CD79A CHGA
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-74	9.66	CD79A

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Drugs & Therapeutics for Collagenous Colitis

Drugs for Collagenous Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Budesonide

Approved

Phase 3,Not Applicable

51333-22-3

63006 5281004

Synonyms:

(11b,16a)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11beta,16alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11-beta,16-alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11β,16α)-16,17-(butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

(R,S)-11b,16a,17,21,tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with buty raldehyde

(RS)-(11beta,16alpha)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione

(RS)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde

(S)-16alpha,17-(Butylidenedioxy)-11beta,21-dihydroxypregna-1,4-diene-3,20-dione

11beta,21-dihydroxy-16alpha,17alpha-(butane-1,1-diyldioxy)pregna-1,4-diene-3,20-dione

16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione

16,17-Butylidenebis(oxy)-11-,21-dihydroxypregna-1,4-diene-3,20-dione

16alpha(R),17-(Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione

16-alpha,17-alpha-Butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-dione

16alpha-,17alpha--butylidenedioxypregna-1,4-diene-11beta-,21-diol-3,20-dione

51333-22-3

AC1L1DQE

AC1L1Y6Y

AC1L22VC

AC1MHWI7

AC-4697

B 7777

B7777_SIGMA

Bidien

Bio-0010

BPBio1_000523

BRD-A34299591-001-03-4

BRD-A82238138-001-01-7

BSPBio_000475

BSPBio_002160

Budecort Inhaler

Budenofalk

Budeson

budesonide

Budesonide (JAN/USAN/INN)

Budesonide [USAN:INN:BAN:JAN]

Budesonide Easyhaler

Budesonide MMX

Budesonide, (R)-isomer

Budesonide, (S)-isomer

Budesonido

Budesonido [INN-Spanish]

Budesonidum

Budesonidum [INN-Latin]

Budiair

Budicort

C25H34O6

CCRIS 5230

CHEBI:3207

CHEBI:656601

CHEMBL1370

CID2462

CID3033890

CID40000

CID5281004

CID63006

Cortivent

CPD000058337

D00246

DB01222

Desowen

Dexbudesonide

Dexbudesonide [INN]

DivK1c_000475

EINECS 257-139-7

EINECS 257-160-1

EINECS 257-161-7

Entocort

Entocort EC

Entocort EC (TN)

EU-0100174

Giona Easyhaler

HMS1569H17

HMS1921I22

HMS2094I13

HMS501H17

Horacort

IDI1_000475

Inflammide

KBio1_000475

KBio3_001660

KBioGR_001361

Lopac0_000174

LS-187734

LS-7235

MAP-0010

Micronyl

Miflonide

MLS000028507

MLS001077323

MLS002207112

MolPort-002-529-265

MolPort-003-666-332

MolPort-003-986-909

NCGC00015165-03

NCGC00021318-03

NCGC00021318-06

NCGC00089747-02

NCGC00089747-03

NCGC00089747-04

NCGC00178789-01

NINDS_000475

Noex

Preferid

Pregna-1,4-diene-3,20-dione, 16,17-butylidenebis(oxy)-11,21-dihydroxy-, (11beta,16alpha(R))-, and 16alpha,17-((S)-Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione

Prestwick_840

Prestwick0_000518

Prestwick1_000518

Prestwick2_000518

Prestwick3_000518

Pulmaxan

Pulmaxan turbohaler

Pulmicort

Pulmicort (TN)

Pulmicort Flexhaler

Pulmicort Nebuamp

Pulmicort Respules

Pulmicort Topinasal

Pulmicort turbuhaler

Pulmicort Turbuhaler

Respules

Rhinocort

Rhinocort alpha

Rhinocort Aqua

Rhinocort Turbuhaler

Rhinocort, Pulmicort , Entocort, Symbicort, Noex. Entocort EC, Budesonide

Rhinosol

S 1320

S1286_Selleck

S-1320

SAM002699898

SMR000058337

SPBio_000586

SPBio_002396

SPECTRUM1500813

Spectrum2_000623

Spectrum3_000620

Spectrum4_000821

Spectrum5_001738

Spirocort

ST51039033

TL8003397

Tridesilon

UDB

UNII-168L5HT37P

UNII-2HI1006KPH

UNII-Q3OKS62Q6X

Unit dose budesonide

ZINC03938751

ZINC04097286

Anti-Asthmatic Agents

Phase 3,Not Applicable

Anti-Inflammatory Agents

Phase 3,Not Applicable

Autonomic Agents

Phase 3,Not Applicable

Bronchodilator Agents

Phase 3,Not Applicable

glucocorticoids

Phase 3,Not Applicable

Hormone Antagonists

Phase 3,Not Applicable

Hormones

Phase 3,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 3,Not Applicable

Peripheral Nervous System Agents

Phase 3,Not Applicable

Respiratory System Agents

Phase 3,Not Applicable

Analgesics

Phase 3

Analgesics, Non-Narcotic

Phase 3

Anti-Inflammatory Agents, Non-Steroidal

Phase 3

Antirheumatic Agents

Phase 3

Mesalamine

Phase 3

89-57-6

Pharmaceutical Solutions

Not Applicable

Antacids

Not Applicable

Anti-Ulcer Agents

Not Applicable

Bismuth

Not Applicable

7440-69-9

16682734 105143

Synonyms:

17034_FLUKA

24267-48-9

25243-76-9

264008_ALDRICH

265462_ALDRICH

265470_ALDRICH

452386_ALDRICH

556130_ALDRICH

7440-69-9

83Bi

95372_ALDRICH

95372_FLUKA

95375_FLUKA

AC1NSDYX

AC1O4PN8

AR-1I0647

Bi(3+)

Bismut

bismuth

Bismuth standard for AAS

Bismuth standard for ICP

Bismuth(III) cation

Bismuth(III) nitrate solution

BISMUTH, 99.95%

BISMUTH, 99.999%

Bismuth, elemental

Bismuth-209

bismuto

Bisumth(3+) ion

C15471

CHEBI:33301

CID5359367

EINECS 231-177-4

HSDB 2078

LS-44708

LTBB002773

MolPort-003-925-759

Wismut

Gastrointestinal Agents

Not Applicable

Cola

Nutraceutical

Not Applicable

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Long-Term Treatment of Collagenous Colitis With Budesonide	Unknown status	NCT00139165	Phase 3	Budesonide
2	Budesonide for Maintenance Treatment of Collagenous Colitis	Completed	NCT00180076	Phase 3	Budesonide
3	Budesonide Capsules vs. Mesalazine Granules vs. Placebo in Collagenous Colitis	Completed	NCT00450086	Phase 3	Budesonide;Mesalazine;Placebo
4	SOIBD Collagenous Colitis Maintenance Study	Completed	NCT01278082	Phase 3	Budesonide;Placebo
5	Usefulness of Chromoendoscopy in Diagnosing Microscopic Colitis	Unknown status	NCT01504048	Not Applicable
6	Case-Control Study to Identify Risk Factors for Microscopic Colitis	Completed	NCT01928667
7	Treatment of Microscopic Colitis	Terminated	NCT00184171	Not Applicable	Budesonide;Bismuth;Fiber

Search NIH Clinical Center for Collagenous Colitis

Cochrane evidence based reviews: colitis, collagenous

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Genetic Tests for Collagenous Colitis

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Anatomical Context for Collagenous Colitis

MalaCards organs/tissues related to Collagenous Colitis:

⁴¹

Colon, Small Intestine, T Cells, Endothelial, Kidney, Heart, Liver

Sources

Publications for Collagenous Colitis

Articles related to Collagenous Colitis:

(show top 50) (show all 450)

#	Title	Authors	Year
1	Evaluation by MR Enterocolonography of Lansoprazole-induced Collagenous Colitis Accompanied with Protein-losing Enteropathy. ( 29033425 )	Mizoguchi A....Hokari R.	2018
2	Vedolizumab as a Novel Treatment for Refractory Collagenous Colitis: A Case Report. ( 29610507 )	Cushing K.C....Khalili H.	2018
3	Interventions for treating collagenous colitis. ( 29127772 )	Kafil T.S....McDonald J.W.	2017
4	Proton pump inhibitor induced collagen expression in colonocytes is associated with collagenous colitis. ( 28321159 )	Mori S....Kuniyasu H.	2017
5	Acute onset collagenous colitis associated with protein-losing enteropathy. ( 29264009 )	Nakaya Y....Yoshimatsu Y.	2017
6	Magnifying image-enhanced endoscopy for collagenous colitis. ( 29250581 )	Kobayashi M....Terai S.	2017
7	Magnifying advanced endoscopy in collagenous colitis: now you see? ( 29250582 )	Koulaouzidis A....Toth E.	2017
8	A case of collagenous colitis associated with novel oral anticoagulants use. ( 28260714 )	Ikemoto J....Yonehara S.	2017
9	Collagenous colitis presenting with skip lesions mimicking Crohn's disease and complicated by intestinal obstruction. ( 28682012 )	Hui C.K....Hui N.K.	2017
10	Spontaneous Tear after Insufflation: A Unique Finding of Collagenous Colitis. ( 28864270 )	Kothadia J.P....Nakayuenyongsuk W.	2017
11	Macroscopic findings in collagenous colitis: a multi-center, retrospective, observational cohort study. ( 28469361 )	Koulaouzidis A....Toth E.	2017
12	Collagenous colitis: Requirement for high-dose budesonide as maintenance treatment. ( 28457904 )	Fernandez-BaA+ares F....Lucendo A.J.	2017
13	Clinical and immunologic effects of faecal microbiota transplantation in a patient with collagenous colitis. ( 28275312 )	GA1naltay S....Bohr J.	2017
14	Anti-PD1-induced collagenous colitis in a melanoma patient. ( 26990271 )	Baroudjian B....Allez M.	2016
15	Elevated fecal levels of eosinophil granule proteins predict collagenous colitis in patients referred to colonoscopy due to chronic non-bloody diarrhea. ( 26854205 )	Wagner M....Carlson M.	2016
16	Pseudomembranes Carpet the Right Colon as a Result of Collagenous Colitis. ( 27725290 )	Resch A....Langner C.	2016
17	Comparison of Clinical Features, Treatment and Outcomes of Collagenous Sprue, Celiac Disease and Collagenous Colitis. ( 27620860 )	Lan N....Liu X.	2016
18	Pseudomembranous Collagenous Colitis: A Case of Not-so-Microscopic Colitis. ( 28119938 )	Grunwald D....Sheth S.G.	2016
19	Tofacitinib Response in Juvenile Idiopathic Arthritis (JIA) and Collagenous Colitis. ( 27870773 )	Tseng B....Brahn E.	2016
20	Smoking Status Influences Clinical Outcome in Collagenous Colitis. ( 26721941 )	MA1nch A....Miehlke S.	2016
21	Spontaneous colonic perforation: a rare complication of collagenous colitis. ( 27178398 )	Cottreau J....Arnason T.	2016
22	Automated image analysis in the study of collagenous colitis. ( 27114713 )	Fiehn A.M....Engel P.J.	2016
23	Optimal management of collagenous colitis: a review. ( 26929656 )	O'Toole A.	2016
24	Collagenous colitis and Crohn's disease: Guilty or innocent bystander? ( 27474197 )	Silva M....Macedo G.	2016
25	Letter: oral low-dose methotrexate for collagenous colitis. ( 27250588 )	Kia Y.H....Dowling D.	2016
26	Collagenous colitis presenting as spontaneous perforation in an 80A year old woman: Report of a Case. ( 27716080 )	Mitchell A....Dugas A.	2016
27	Letter: oral low-dose methotrexate for collagenous colitis - authors' reply. ( 27250589 )	FernA!ndez-BaA+ares F....Gisbert J.P.	2016
28	Immunological Differences between Lymphocytic and Collagenous Colitis. ( 26928959 )	Carrasco A....FernA!ndez-BaA+ares F.	2016
29	Collagenous Colitis Refractory to Budesonide: is the Upper Gastrointestinal Tract Involved? ( 27557639 )	Agudo B....Abreu L.E.	2016
30	Collagenous Colitis Associated with Protein-losing Enteropathy. ( 26568022 )	Nakaya Y....Kitamura S.	2015
31	Dense genotyping of immune-related loci identifies HLA variants associated with increased risk of collagenous colitis. ( 26525574 )	Westerlind H....D'Amato M.	2015
32	Fecal stream diversion and mucosal cytokine levels in collagenous colitis: A case report. ( 26019474 )	Daferera N....MA1nch A.	2015
33	Severe acute kidney injury as a complication of collagenous colitis. ( 26561416 )	Silva M....Macedo G.	2015
34	P171. Smoking is associated with watery diarrhea and decreased likelihood to achieve clinical remission in collagenous colitis. ( 25717636 )		2015
35	Microscopic (collagenous) colitis in a patient with a heart transplant. ( 26115392 )	Rehlen T....Eisenbach C.	2015
36	Increased Production of Lysozyme Associated with Bacterial Proliferation in Barrett's Esophagitis, Chronic Gastritis, Gluten-induced Atrophic Duodenitis (Celiac Disease), Lymphocytic Colitis, Collagenous Colitis, Ulcerative Colitis and Crohn's Colitis. ( 26637845 )	Rubio C.A.	2015
37	DOP082. Genome-wide association identifies multiple collagenous colitis susceptibility loci. ( 25718298 )		2015
38	Collagenous Colitis Associated with Rabeprazole in a Peritoneal Dialysis Patient. ( 26450480 )	Murasawa M....Kimura K.	2015
39	Collagenous colitis with mucosal ulcerations in a patient without nonsteroidal anti-inflammatory drug or lansoprazole use. ( 26130218 )	Berry A.C....Baltz A.C.	2015
40	Pseudomembranous variant of collagenous colitis. ( 26508688 )	Harpaz N....Zhang D.	2015
41	Mucosal tears and colonic perforation in a patient with collagenous colitis. ( 24523187 )	van Eijk R.L....Bac D.J.	2014
42	Acute onset collagenous colitis with unique endoscopic findings. ( 25610672 )	Moroi R....Shimosegawa T.	2014
43	O-018a88genome-wide association identifies multiple collagenous colitis susceptibility Loci. ( 25407172 )	Giulia R....Jean-FrAcdAcric C.	2014
44	Efficacy of budesonide in collagenous colitis Evaluation of: Miehlke S, Madisch A, Kupcinskas L, et al. Budesonide is more effective than mesalamine or placebo in short-term treatment of collagenous colitis. Gastroenterology 2014;146(5):1222-1230 e1222. ( 25164577 )	Drug V.L....Antoniu S.A.	2014
45	Budesonide is more effective than mesalamine or placebo in short-term treatment of collagenous colitis. ( 24440672 )	Miehlke S....Bonderup O.K.	2014
46	Low-dose budesonide for maintenance of clinical remission in collagenous colitis: a randomised, placebo-controlled, 12-month trial. ( 25425655 )	MA1nch A....StrAPm M.	2014
47	Collagenous colitis during treatment with fumaric acid esters. ( 25482705 )	Hoffmann K....Schempp C.M.	2014
48	Collagenous colitis in systemic sclerosis: an overlooked and treatable complication. ( 25036565 )	Abignano G....Del Galdo F.	2014
49	Clinical characteristics of collagenous colitis with linear ulcerations. ( 23560988 )	Saito S....Osaki Y.	2014
50	Pseudomembranous collagenous colitis: an unusual cause of chronic diarrhoea. ( 24526204 )	Khan-Kheil A.M....Wood G.	2014

Sources

Genes for Collagenous Colitis

Genes related to Collagenous Colitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	RNASE3	Ribonuclease A Family Member 3	Protein Coding	24.28	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11330429 17109497
2	NOS2	Nitric Oxide Synthase 2	Protein Coding	21.92	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	16957516 11511561 12229970 (more) 15641395
3	MPO	Myeloperoxidase	Protein Coding	21.58	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	COL14A1	Collagen Type XIV Alpha 1 Chain	Protein Coding	20.8	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	CHGA	Chromogranin A	Protein Coding	20.71	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	SCG2	Secretogranin II	Protein Coding	20.65	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	CHGB	Chromogranin B	Protein Coding	20.58	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	CD79A	CD79a Molecule	Protein Coding	20.57	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	EPX	Eosinophil Peroxidase	Protein Coding	19.92	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	MMP1	Matrix Metallopeptidase 1	Protein Coding	19.73	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

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Variations for Collagenous Colitis

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Expression for Collagenous Colitis

Search GEO for disease gene expression data for Collagenous Colitis.

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Pathways for Collagenous Colitis

Pathways related to Collagenous Colitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	12.76	CD79A CHGA EPX MMP1 MPO NOS2
2	Hepatitis C and Hepatocellular Carcinoma ¹	10.66	MMP1 NOS2

Sources

GO Terms for Collagenous Colitis

Cellular components related to Collagenous Colitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.63	CHGA COL14A1 EPX MPO RNASE3 SCG2
2	extracellular region	GO:0005576	9.56	CHGA CHGB COL14A1 EPX MMP1 MPO
3	endoplasmic reticulum lumen	GO:0005788	9.43	CHGB COL14A1 SCG2
4	secretory granule	GO:0030141	8.92	CHGA CHGB MPO SCG2

Biological processes related to Collagenous Colitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular protein metabolic process	GO:0044267	9.54	CHGB MMP1 SCG2
2	antimicrobial humoral response	GO:0019730	9.4	CHGA RNASE3
3	defense response to fungus	GO:0050832	9.32	CHGA MPO
4	innate immune response in mucosa	GO:0002227	9.26	NOS2 RNASE3
5	hydrogen peroxide catabolic process	GO:0042744	9.16	EPX MPO
6	defense response to Gram-negative bacterium	GO:0050829	9.13	CHGA NOS2 RNASE3
7	defense response to bacterium	GO:0042742	9.02	CHGA EPX MPO NOS2 RNASE3

Molecular functions related to Collagenous Colitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peroxidase activity	GO:0004601	8.96	EPX MPO
2	heme binding	GO:0020037	8.8	EPX MPO NOS2

Sources

Sources for Collagenous Colitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia