Collagenous Colitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CLL021 MIFTS: 42	Collagenous Colitis Categories: Gastrointestinal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Collagenous Colitis

MalaCards integrated aliases for Collagenous Colitis:

Name: Collagenous Colitis ¹² ⁷⁴ ²⁰ ⁵⁴ ¹⁵ ¹⁷

Colitis, Collagenous ⁴⁴ ⁷¹

Microscopic Colitis, Collagenous Type ²⁰

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060183

MeSH ⁴⁴ D046729

NCIt ⁵⁰ C27021

SNOMED-CT ⁶⁷ 19311003

ICD10 ³² K52.831

EFO ¹⁷ EFO_1001293

UMLS ⁷¹ C0238067

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Summaries for Collagenous Colitis

GARD : ²⁰ Collagenous colitis is a type of inflammatory bowel disease that affects the colon. It is a form of microscopic colitis, which causes chronic diarrhea. It typically occurs in middle-aged adults, is more common in females than in males, and has rarely been reported in children. In all forms of microscopic colitis, the colon appears normal or almost normal on colonoscopy, but the inflammation is visible when a biopsy of the colon is examined under a microscope (hence its name). Signs and symptoms include chronic, watery, non-bloody diarrhea that may begin suddenly or worsen over time. People with this disease usually have between four and nine watery bowel movements per day, but in rare cases may have more than fifteen. Various other symptoms relating to the gastrointestinal system or other body symptoms may also be present. The cause of collagenous colitis is not known but it is thought to be multifactorial. This means that both genetic and environmental factors may interact to cause a person to develop the disease. The extent to which genes play a role is unclear, but familial cases have been described. Certain medications, such as NSAIDS and proton pump inhibitors, have been reported to cause or trigger the disease in some people. However, strong evidence directly linking these medications to the disease is still lacking. The main goal of treatment is to lessen the number of bowel movements per day and improve quality of life. Treatment depends on the symptoms and severity in each person and may involve avoiding or discontinuing medications that may be associated with the disease, taking anti-diarrheal medications, budesonide, or other medications. Surgery to remove all or part of the colon may be needed in severe cases that do not respond to other treatments. In some cases, diarrhea resolves within weeks (with or without treatment), but relapses are common.

MalaCards based summary : Collagenous Colitis, also known as colitis, collagenous, is related to lymphocytic colitis and pyoderma. An important gene associated with Collagenous Colitis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Innate Immune System and Degradation of the extracellular matrix. The drugs Budesonide and Rifaximin have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and endothelial, and related phenotype is homeostasis/metabolism.

Disease Ontology : ¹² A colitis characterized by a distinctive thickening of the subepithelial collagen table.

Wikipedia : ⁷⁴ Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak... more...

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Related Diseases for Collagenous Colitis

Diseases related to Collagenous Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 226)

#	Related Disease	Score	Top Affiliating Genes
1	lymphocytic colitis	31.2	MMP9 CLDN4 CHGA
2	pyoderma	30.3	NOD2 MMP9 MMP1
3	pyoderma gangrenosum	30.3	NOD2 MMP9 MMP1
4	proteasome-associated autoinflammatory syndrome 1	29.9	RNASE3 NOS2 MPO MMP9
5	proctitis	29.9	RNASE3 MPO EPX
6	hypereosinophilic syndrome	29.8	RNASE3 MPO EPX
7	allergic rhinitis	29.4	RNASE3 MPO EPX
8	rheumatoid arthritis	29.0	TIMP1 NOS2 MPO MMP9 MMP1
9	pulmonary fibrosis	29.0	TIMP1 MPO MMP9 MMP1 CCN2
10	inflammatory bowel disease	28.9	TIMP1 NOS2 NOD2 MPO MMP9 MMP1
11	microscopic colitis	11.3
12	colitis	11.2
13	collagenous gastritis	11.2
14	diarrhea	11.0
15	celiac disease 1	10.6
16	ulcerative colitis	10.6
17	crohn's disease	10.4
18	autoimmune disease	10.4
19	protein-losing enteropathy	10.4
20	gastritis	10.4
21	crohn's colitis	10.4
22	chronic maxillary sinusitis	10.3	RNASE3 MPO
23	maxillary sinusitis	10.3	RNASE3 MPO
24	internal hemorrhoid	10.3	NOS2 MMP9
25	hemorrhoid	10.3	NOS2 MMP9
26	adhesive otitis media	10.3	RNASE3 MPO
27	patulous eustachian tube	10.3	RNASE3 MPO
28	mycetoma	10.3	NOS2 MMP9
29	clostridium difficile colitis	10.2
30	intestinal disease	10.2
31	lentigo maligna melanoma	10.2	TIMP1 MMP9
32	anorectal stricture	10.2	NOD2 CLDN4
33	fungal keratitis	10.2	TIMP1 MMP9
34	systemic lupus erythematosus	10.2
35	scleroderma, familial progressive	10.2
36	arthropathy	10.2
37	thyroiditis	10.2
38	duodenitis	10.2
39	irritable bowel syndrome	10.2
40	gallbladder small cell carcinoma	10.2	CHGB CHGA
41	glucagonoma	10.2	CHGB CHGA
42	adrenal neuroblastoma	10.2	CHGB CHGA
43	bronchitis	10.2	RNASE3 MPO MMP9
44	peritoneal serous adenocarcinoma	10.2	CLDN4 CHGA
45	carcinoid tumors, intestinal	10.2	CHGB CHGA
46	spondyloarthropathy	10.1
47	megacolon	10.1
48	inflammatory spondylopathy	10.1
49	common variable immunodeficiency	10.1
50	toxic megacolon	10.1

Graphical network of the top 20 diseases related to Collagenous Colitis:

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Symptoms & Phenotypes for Collagenous Colitis

MGI Mouse Phenotypes related to Collagenous Colitis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.4	CCN2 CHGA CHGB CLDN4 COL14A1 EPX

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Drugs & Therapeutics for Collagenous Colitis

Drugs for Collagenous Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Budesonide

Approved

Phase 3

51333-22-3

63006 5281004

Synonyms:

(11b,16a)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11beta,16alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11-beta,16-alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11β,16α)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(11Β,16α)-16,17-(butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

(R,S)-11b,16a,17,21,tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with buty raldehyde

(RS)-(11beta,16alpha)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione

(RS)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde

(S)-16alpha,17-(Butylidenedioxy)-11beta,21-dihydroxypregna-1,4-diene-3,20-dione

11beta,21-dihydroxy-16alpha,17alpha-(butane-1,1-diyldioxy)pregna-1,4-diene-3,20-dione

16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione

16,17-Butylidenebis(oxy)-11-,21-dihydroxypregna-1,4-diene-3,20-dione

16alpha(R),17-(Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione

16-alpha,17-alpha-Butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-dione

16alpha-,17alpha--butylidenedioxypregna-1,4-diene-11beta-,21-diol-3,20-dione

51333-22-3

AC1L1DQE

AC1L1Y6Y

AC1L22VC

AC1MHWI7

AC-4697

B 7777

B7777_SIGMA

Bidien

Bio-0010

BPBio1_000523

BRD-A34299591-001-03-4

BRD-A82238138-001-01-7

BSPBio_000475

BSPBio_002160

Budecort Inhaler

Budenofalk

Budeson

Budesónida

budesonide

Budesonide

Budesonide (JAN/USAN/INN)

Budesonide [USAN:INN:BAN:JAN]

Budesonide Easyhaler

Budesonide MMX

Budesonide, (R)-isomer

Budesonide, (S)-isomer

Budesonido

Budesonido [INN-Spanish]

Budesonidum

Budesonidum [INN-Latin]

Budiair

Budicort

C25H34O6

CCRIS 5230

CHEBI:3207

CHEBI:656601

CHEMBL1370

CID2462

CID3033890

CID40000

CID5281004

CID63006

Cortivent

CPD000058337

D00246

DB01222

Desowen

Dexbudesonide

Dexbudesonide [INN]

DivK1c_000475

EINECS 257-139-7

EINECS 257-160-1

EINECS 257-161-7

Entocort

Entocort ec

Entocort EC

Entocort EC (TN)

EU-0100174

Giona Easyhaler

HMS1569H17

HMS1921I22

HMS2094I13

HMS501H17

Horacort

IDI1_000475

Inflammide

KBio1_000475

KBio3_001660

KBioGR_001361

Lopac0_000174

LS-187734

LS-7235

MAP-0010

Micronyl

Miflonide

MLS000028507

MLS001077323

MLS002207112

MolPort-002-529-265

MolPort-003-666-332

MolPort-003-986-909

NCGC00015165-03

NCGC00021318-03

NCGC00021318-06

NCGC00089747-02

NCGC00089747-03

NCGC00089747-04

NCGC00178789-01

NINDS_000475

Noex

Preferid

Pregna-1,4-diene-3,20-dione, 16,17-butylidenebis(oxy)-11,21-dihydroxy-, (11beta,16alpha(R))-, and 16alpha,17-((S)-Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione

Prestwick_840

Prestwick0_000518

Prestwick1_000518

Prestwick2_000518

Prestwick3_000518

Pulmaxan

Pulmaxan turbohaler

Pulmicort

Pulmicort (TN)

Pulmicort Flexhaler

Pulmicort Nebuamp

Pulmicort Respules

Pulmicort Topinasal

Pulmicort turbuhaler

Pulmicort Turbuhaler

Respules

Rhinocort

Rhinocort alpha

Rhinocort Aqua

Rhinocort Turbuhaler

Rhinocort, Pulmicort , Entocort, Symbicort, Noex. Entocort EC, Budesonide

Rhinosol

S 1320

S1286_Selleck

S-1320

SAM002699898

SMR000058337

SPBio_000586

SPBio_002396

SPECTRUM1500813

Spectrum2_000623

Spectrum3_000620

Spectrum4_000821

Spectrum5_001738

Spirocort

ST51039033

TL8003397

Tridesilon

Uceris

UDB

UNII-168L5HT37P

UNII-2HI1006KPH

UNII-Q3OKS62Q6X

Unit dose budesonide

ZINC03938751

ZINC04097286

Rifaximin

Approved, Investigational

Phase 3

80621-81-4

6436173 46783403

Synonyms:

(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26S,27S,28E)-5,6,21,23,25 Pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2H)-dione, 25-acetate

(7S,9Z,11S,12R,13S,14R,15R,16R,17S,18S,19Z,21Z)-2,15,17,23,36-Pentahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6-oxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.1,.0,.0,.0,]heptatriaconta-1(35),2,4,9,19,21,23,25(36),26(34),28,30,32-dodecaen-13-yl acetic acid

4-deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin

4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin

4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4-c)rifamycin SV

80621-81-4

88747-56-2

AC-19112

alpha-0817185

Bio-0556

BRN 3584528

C43H51N3O11

CHEMBL1617

D02554

DB01220

Fatroximin

Flonorm

L 105

L 105 (Ansamacrolide antibiotic)

L 105SV

Lormyx

LS-178059

LS-64147

Lumenax

MLS000759430

Normix

Redactiv

RedActiv

Rifacol

Rifamixin

Rifamycin L 105

Rifamycin L 105SV

Rifaxidin

Rifaximin

Rifaximin (USAN/INN)

Rifaximin [USAN:INN]

Rifaximina

Rifaximina [Spanish]

Rifaximine

Rifaximine [French]

Rifaximinum

Rifaximinum [Latin]

Rifaximinun

Rifaxin

Ritacol

S1790_Selleck

SMR000466324

Spiraxin

UNII-L36O5T016N

Xifaxan

Xifaxan, Rifacol, Fatroximin, Rifaximin

Xifaxsan

Xifaxsan (TN)

Respiratory System Agents

Phase 3

Anti-Asthmatic Agents

Phase 3

Anti-Inflammatory Agents

Phase 3

Hormone Antagonists

Phase 3

Hormones

Phase 3

glucocorticoids

Phase 3

Bronchodilator Agents

Phase 3

Mesalamine

Phase 3

89-57-6

Anti-Inflammatory Agents, Non-Steroidal

Phase 3

Antirheumatic Agents

Phase 3

Analgesics, Non-Narcotic

Phase 3

Analgesics

Phase 3

Gastrointestinal Agents

Phase 3

Anti-Infective Agents

Phase 3

Anti-Bacterial Agents

Phase 3

Cola

Pharmaceutical Solutions

Antacids

Anti-Ulcer Agents

Bismuth

7440-69-9

16682734 105143

Synonyms:

17034_FLUKA

24267-48-9

25243-76-9

264008_ALDRICH

265462_ALDRICH

265470_ALDRICH

452386_ALDRICH

556130_ALDRICH

7440-69-9

83Bi

95372_ALDRICH

95372_FLUKA

95375_FLUKA

AC1NSDYX

AC1O4PN8

AR-1I0647

Bi(3+)

Bismut

bismuth

Bismuth standard for AAS

Bismuth standard for ICP

Bismuth(III) cation

Bismuth(III) nitrate solution

BISMUTH, 99.95%

BISMUTH, 99.999%

Bismuth, elemental

Bismuth-209

bismuto

Bisumth(3+) ion

C15471

CHEBI:33301

CID5359367

EINECS 231-177-4

HSDB 2078

LS-44708

LTBB002773

MolPort-003-925-759

Wismut

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Long-Term Treatment of Collagenous Colitis With Budesonide. Prospective, Doubleblind Placebo-Controlled Trial.	Unknown status	NCT00139165	Phase 3	Budesonide
2	Double-blind, Randomised, Placebo-controlled, Multi-centre Phase III Clinical Study on the Efficacy and Tolerability of Budesonide Capsules Versus Placebo for Maintenance of Remission in Patients With Collagenous Colitis	Completed	NCT01278082	Phase 3	Budesonide;Placebo
3	Efficacy and Safety of Budesonide in Maintenance Treatment of Collagenous Colitis	Completed	NCT00180076	Phase 3	Budesonide
4	Double-blind, Double-dummy, Randomised, Placebo-controlled, Multi-centre Phase III Clinical Study on the Efficacy and Tolerability of Budesonide Capsules vs. Mesalazine Granules vs. Placebo for Patients With Collagenous Colitis.	Completed	NCT00450086	Phase 3	Budesonide;Mesalazine;Placebo
5	Rifaximin-treatment of Collagenous Colitis:	Not yet recruiting	NCT03658993	Phase 3	Rifaximin 550 MG
6	Prospective Study on the Usefulness of Chromoendoscopy in Detecting Microscopic Colitis in Patients Undergoing Colonoscopy Due to Chronic Watery Diarrhoea	Unknown status	NCT01504048
7	Risk Factors for Microscopic Colitis: A Dutch Case-Control Study	Completed	NCT01928667
8	Treatment of Microscopic Colitis (Collagenous Colitis and Lymphocytic Colitis) With Budesonide, Bismuth or Fiber	Terminated	NCT00184171		Budesonide;Bismuth;Fiber

Search NIH Clinical Center for Collagenous Colitis

Cochrane evidence based reviews: colitis, collagenous

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Genetic Tests for Collagenous Colitis

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Anatomical Context for Collagenous Colitis

MalaCards organs/tissues related to Collagenous Colitis:

⁴⁰

Colon, T Cells, Endothelial, Small Intestine, Neutrophil, Heart, Kidney

Sources

Publications for Collagenous Colitis

Articles related to Collagenous Colitis:

(show top 50) (show all 985)

#	Title	Authors	PMID	Year
1	Steroids reduce local inflammatory mediator secretion and mucosal permeability in collagenous colitis patients. ⁶¹ ⁵⁴	Taha Y...Thorn M	17109497	2006
2	Budesonide treatment and expression of inducible nitric oxide synthase mRNA in colonic mucosa in collagenous colitis. ⁶¹ ⁵⁴	Bonderup OK...Teglbjaerg PS	16957516	2006
3	Chronic diarrhoea in non collagenous microscopic colitis: therapeutic effect of cholestyramine. ⁶¹ ⁵⁴	Baert D...Vanderstraeten E	15641395	2004
4	Constitutive expression of inducible nitric oxide synthase in the normal human colonic epithelium. ⁵⁴ ⁶¹	Perner A...Rask-Madsen J	12229970	2002
5	Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis. ⁶¹ ⁵⁴	Perner A...Rask-Madsen J	11511561	2001
6	Evidence of local eosinophil activation and altered mucosal permeability in collagenous colitis. ⁶¹ ⁵⁴	Taha Y...Raab Y	11330429	2001
7	Comorbid Occurrence of Eosinophilic Esophagitis and Inflammatory Bowel Disease. ⁶¹	Sonnenberg A...Genta RM	32068153	2021
8	Medication-specific variations in morphological patterns of injury in immune check-point inhibitor-associated colitis. ⁶¹	Isidro RA...Srivastava A	32931028	2021
9	Collagenous colitis and atezolizumab therapy: an atypical case. ⁶¹	Gallo A...Montalto M	33151423	2021
10	Novel Case Report: A Previously Reported, but Pathophysiologically Unexplained, Association Between Collagenous Colitis and Protein-Losing Enteropathy May Be Explained by an Undetected Link with Collagenous Duodenitis. ⁶¹	Gill I...Cappell MS	33537921	2021
11	Bile Acid Sequestrant Therapy in Microscopic Colitis. ⁶¹	Northcutt MJ...Yen EF	33443968	2021
12	Distribution of histopathological features along the colon in microscopic colitis. ⁶¹	Fiehn AK...Munch A	32920702	2021
13	A case of collagenous colitis with endoscopic changes enhanced by indigo carmine chromoendoscopy. ⁶¹	Funari MP...de Moura EGH	33359259	2020
14	Lymphocytic and collagenous colitis in children and adolescents: Comprehensive clinicopathologic analysis with long-term follow-up. ⁶¹	Windon AL...Voltaggio L	32991931	2020
15	Anti-PD-1 induced collagenous colitis in metastatic melanoma: a rare severe adverse event. ⁶¹	Janela-Lapert R...Joly P	32404733	2020
16	Collagenous Colitis Mucosa Is Characterized by an Expansion of Nonsuppressive FoxP3+ T Helper Cells. ⁶¹	Daferera N...Munch A	33319252	2020
17	Faecal microbiota transfer in patients with microscopic colitis - a pilot study in collagenous colitis. ⁶¹	Holster S...Konig J	33142068	2020
18	Epidemiological and clinical characteristics, and response to treatment in 113 patients with microscopic colitis. ⁶¹	Rojo E...P Gisbert J	33248178	2020
19	High risk of microscopic colitis after Campylobacter concisus infection: population-based cohort study. ⁶¹	Nielsen HL...Nielsen H	32111632	2020
20	Increasing Incidence of Microscopic Colitis in a Population-Based Cohort Study in Switzerland. ⁶¹	Maye H...Schoepfer AM	33065310	2020
21	Disease activity patterns, mortality and colorectal cancer risk in microscopic colitis: a Danish nationwide cohort study, 2001 to 2016. ⁶¹	Weimers P...Burisch J	33049029	2020
22	Colitis nucleomigrans: The third type of microscopic colitis (part 1). ⁶¹	Tachibana M...Tsutsumi Y	32761850	2020
23	Topographical distribution of microscopic colitis and the importance of orientation of paraffin-embedded biopsies. ⁶¹	Kanstrup Fiehn AM...Villanacci V	32673680	2020
24	Cannabidiol Oil-Associated Microscopic Colitis. ⁶¹	Oruganti P...Abegunde AT	33094069	2020
25	Gastrointestinal Malakoplakia: Clinicopathologic Analysis of 26 Cases. ⁶¹	Zhang Y...Voltaggio L	32301754	2020
26	Biopsies From Ascending and Descending Colon Are Sufficient for Diagnosis of Microscopic Colitis. ⁶¹	Virine B...Driman DK	32109628	2020
27	Campylobacter concisus is prevalent in the gastrointestinal tract of patients with microscopic colitis. ⁶¹	Yde Aagaard ME...Nielsen H	32667235	2020
28	European guidelines on microscopic colitis: United European Gastroenterology (UEG) and European Microscopic Colitis Group (EMCG) statements and recommendations. ⁶¹	Miehlke S...Munch A	32819215	2020
29	Collagenous Colitis Is Associated With HLA Signature and Shares Genetic Risks With Other Immune-Mediated Diseases. ⁶¹	Stahl E...Peter I	32371109	2020
30	Collagenous colitis in a child induced by chronic respiratory allergy: A case report. ⁶¹	Wan XM...Xie YM	32871927	2020
31	All-cause and cause-specific mortality in microscopic colitis: a Danish nationwide matched cohort study. ⁶¹	Nyboe Andersen N...Wildt S	32583929	2020
32	Aquaporin-5 Expression Is Reduced in Lymphocytic Colitis. ⁶¹	Tong YT...Younes M	32826239	2020
33	The Water Channel Aquaporin 8 is a Critical Regulator of Intestinal Fluid Homeostasis in Collagenous Colitis. ⁶¹	Escudero-Hernandez C...Koch S	32016376	2020
34	[An unusual digestive complication under anti-PD-1 (pembrolizumab)]. ⁶¹	Calvani J...Bertheau P	32107038	2020
35	An investigation of European pathologists' approach to diagnose microscopic colitis. ⁶¹	Goudkade D...Engel PJH	32278285	2020
36	Incidence and prevalence of microscopic colitis between 2001 and 2016: A Danish nationwide cohort study. ⁶¹	Weimers P...Munkholm P	32502240	2020
37	The association between smoking and both types of microscopic colitis: A systematic review and meta-analysis. ⁶¹	Al Momani L...Young M	32241698	2020
38	Clinicopathological significance of lymphocytic colitis/collagenous colitis in inflammatory bowel disease. ⁶¹	Yuan L...Zhang L	31698005	2020
39	Undiagnosed microscopic colitis: a hidden cause of chronic diarrhoea and a frequently missed treatment opportunity. ⁶¹	Munch A...Hungin APS	32419914	2020
40	Increased Mast Cell Counts and Degranulation in Microscopic Colitis. ⁶¹	Chi Z...Saxena R	32148478	2020
41	Treatment of microscopic colitis: the role of budesonide and new alternatives for refractory patients. ⁶¹	Rojo E...Gisbert JP	31880163	2020
42	Faecal microbiota transplantation in Clostridioides difficile infection: real-life experience from an academic Italian hospital. ⁶¹	Barberio B...Savarino EV	32774464	2020
43	Pediatric Collagenous Gastroenterocolitis Successfully Treated with Methotrexate. ⁶¹	Beinvogl BC...Verhave M	32181040	2020
44	Immune-related adverse events in the gastrointestinal tract: diagnostic utility of upper gastrointestinal biopsies. ⁶¹	Zhang ML...Deshpande V	31361907	2020
45	Faecal Calprotectin and 7-α Cholestenone Levels in Microscopic Colitis: Experience from Edinburgh. ⁶¹	Davie M...Koulaouzidis A	32440188	2020
46	Beclomethasone dipropionate in microscopic colitis: Results of an exploratory open-label multicentre study (COLCO). ⁶¹	Corte T...Baert F	31700631	2019
47	Effects of subspecialty signout and group consensus on the diagnosis of microscopic colitis. ⁶¹	Sharma M...Gonzalez RS	31359149	2019
48	Cancer Risk in Collagenous Colitis. ⁶¹	Larsson JK...Sjoberg K	31718057	2019
49	Wavy mucosal tear in the sigmoid colon. ⁶¹	Tominaga K...Terai S	31534768	2019
50	Budesonide treatment for microscopic colitis: systematic review and meta-analysis. ⁶¹	Sebastian S...Veysey M	31211724	2019

Sources

Genes for Collagenous Colitis

Genes related to Collagenous Colitis (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	RNASE3	Ribonuclease A Family Member 3	Protein Coding	15.55	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	11330429 17109497
2	SCG2	Secretogranin II	Protein Coding	12.74	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	CLDN4	Claudin 4	Protein Coding	12.53	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	NOS2	Nitric Oxide Synthase 2	Protein Coding	12.28	Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	16957516 11511561 12229970 (more) 15641395
5	CHGB	Chromogranin B	Protein Coding	12.27	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	MPO	Myeloperoxidase	Protein Coding	12.19	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	CHGA	Chromogranin A	Protein Coding	11.98	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	TIMP1	TIMP Metallopeptidase Inhibitor 1	Protein Coding	11.44	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	11.3	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	COL14A1	Collagen Type XIV Alpha 1 Chain	Protein Coding	11.2	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	MMP1	Matrix Metallopeptidase 1	Protein Coding	11.19	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	MMP9	Matrix Metallopeptidase 9	Protein Coding	10.99	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	EPX	Eosinophil Peroxidase	Protein Coding	10.96	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	CCN2	Cellular Communication Network Factor 2	Protein Coding	10.32	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Collagenous Colitis

Sources

Expression for Collagenous Colitis

Search GEO for disease gene expression data for Collagenous Colitis.

Sources

Pathways for Collagenous Colitis

Pathways related to Collagenous Colitis according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.65	TIMP1 RNASE3 NOS2 NOD2 MPO MMP9
2	Degradation of the extracellular matrix ⁶⁵ Show member pathways Collagen degradation ⁶⁵ Extracellular matrix organization ⁶⁵	12.43	TIMP1 MMP9 MMP1 COL14A1
3	Colorectal Cancer Metastasis ⁶³	11.9	NOS2 MMP9 MMP1
4	Matrix Metalloproteinases ¹ Show member pathways Activation of Matrix Metalloproteinases ⁶⁵ Inhibition of Matrix Metalloproteinases ⁶³	11.54	TIMP1 MMP9 MMP1
5	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²³	11.3	NOS2 MMP9 MMP1
6	Lung fibrosis ¹	11.23	TIMP1 MMP9 CCN2
7	Cell adhesion_ECM remodeling ²³	11.12	TIMP1 MMP9 MMP1
8	Interleukin-4 and 13 signaling ⁶⁵	10.98	TIMP1 NOS2 MMP9 MMP1
9	IL1 and megakaryocytes in obesity ¹	10.89	TIMP1 MMP9
10	amb2 Integrin signaling ¹	10.81	MPO MMP9 CCN2
11	Immune response_Oncostatin M signaling via JAK-Stat in human cells ²³	10.74	TIMP1 MMP1
12	Syndecan-1-mediated signaling events ¹	10.66	MMP9 MMP1

Sources

GO Terms for Collagenous Colitis

Cellular components related to Collagenous Colitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum lumen	GO:0005788	9.67	TIMP1 SCG2 COL14A1 CHGB
2	extracellular matrix	GO:0031012	9.65	TIMP1 MMP9 MMP1 COL14A1 CCN2
3	extracellular space	GO:0005615	9.65	TIMP1 SCG2 RNASE3 MPO MMP9 EPX
4	secretory granule	GO:0030141	9.46	SCG2 MPO CHGB CHGA
5	extracellular region	GO:0005576	9.36	TIMP1 SCG2 RNASE3 MPO MMP9 MMP1
6	neuronal dense core vesicle	GO:0098992	9.32	SCG2 CHGA

Biological processes related to Collagenous Colitis according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	neutrophil degranulation	GO:0043312	9.8	RNASE3 MPO MMP9 EPX
2	cytokine-mediated signaling pathway	GO:0019221	9.73	TIMP1 NOS2 MMP9 MMP1
3	response to lipopolysaccharide	GO:0032496	9.7	NOS2 NOD2 MPO
4	defense response	GO:0006952	9.65	NOD2 MPO EPX
5	defense response to Gram-positive bacterium	GO:0050830	9.63	RNASE3 NOD2 CHGA
6	cellular protein metabolic process	GO:0044267	9.56	TIMP1 SCG2 MMP1 CHGB
7	defense response to Gram-negative bacterium	GO:0050829	9.54	RNASE3 NOS2 CHGA
8	hydrogen peroxide catabolic process	GO:0042744	9.51	MPO EPX
9	extracellular matrix disassembly	GO:0022617	9.5	TIMP1 MMP9 MMP1
10	positive regulation of cardiac muscle contraction	GO:0060452	9.4	CHGA CCN2
11	innate immune response in mucosa	GO:0002227	9.33	RNASE3 NOS2 NOD2
12	cellular response to UV-A	GO:0071492	9.13	TIMP1 MMP9 MMP1
13	defense response to bacterium	GO:0042742	9.1	RNASE3 NOS2 NOD2 MPO EPX CHGA

Molecular functions related to Collagenous Colitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	heme binding	GO:0020037	8.8	NOS2 MPO EPX

Sources

Sources for Collagenous Colitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia