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MCID: CLL021
MIFTS: 42

Collagenous Colitis

Categories: Gastrointestinal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Collagenous Colitis

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MalaCards integrated aliases for Collagenous Colitis:

Name: Collagenous Colitis 12 75 53 55 15 17
Colitis, Collagenous 44 72
Microscopic Colitis, Collagenous Type 53

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060183
MeSH 44 D046729
NCIt 50 C27021
SNOMED-CT 68 19311003
ICD10 33 K52.831
UMLS 72 C0238067
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Summaries for Collagenous Colitis

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NIH Rare Diseases : 53 Collagenous colitis is a type of inflammatory bowel disease that affects the colon. It is a form of microscopic colitis, which causes chronic diarrhea. It typically occurs in middle-aged adults, is more common in females than in males, and has rarely been reported in children. In all forms of microscopic colitis, the colon appears normal or almost normal on colonoscopy, but the inflammation is visible when a biopsy of the colon is examined under a microscope (hence its name). Signs and symptoms include chronic, watery, non-bloody diarrhea that may begin suddenly or worsen over time. People with this disease usually have between four and nine watery bowel movements per day, but in rare cases may have more than fifteen. Various other symptoms relating to the gastrointestinal system or other body symptoms may also be present. The cause of collagenous colitis is not known but it is thought to be multifactorial. This means that both genetic and environmental factors may interact to cause a person to develop the disease. The extent to which genes play a role is unclear, but familial cases have been described. Certain medications, such as NSAIDS and proton pump inhibitors, have been reported to cause or trigger the disease in some people. However, strong evidence directly linking these medications to the disease is still lacking. The main goal of treatment is to lessen the number of bowel movements per day and improve quality of life. Treatment depends on the symptoms and severity in each person and may involve avoiding or discontinuing medications that may be associated with the disease, taking anti-diarrheal medications, budesonide, or other medications. Surgery to remove all or part of the colon may be needed in severe cases that do not respond to other treatments. In some cases, diarrhea resolves within weeks (with or without treatment), but relapses are common.

MalaCards based summary : Collagenous Colitis, also known as colitis, collagenous, is related to lymphocytic colitis and pelvic organ prolapse. An important gene associated with Collagenous Colitis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Innate Immune System and Colorectal Cancer Metastasis. The drugs Rifaximin and Budesonide have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and small intestine, and related phenotype is muscle.

Disease Ontology : 12 A colitis characterized by a distinctive thickening of the subepithelial collagen table.

Wikipedia : 75 Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak... more...

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Related Diseases for Collagenous Colitis

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Diseases related to Collagenous Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 199)
# Related Disease Score Top Affiliating Genes
1 lymphocytic colitis 31.4 MMP9 CHGA
2 pelvic organ prolapse 29.9 MMP9 MMP1
3 proctitis 29.5 RNASE3 MPO EPX
4 proteasome-associated autoinflammatory syndrome 1 29.5 RNASE3 NOS2 MPO MMP9
5 food allergy 29.2 RNASE3 EPX
6 obsolete: collagenous colitis 12.4
7 microscopic colitis 11.7
8 collagenous gastritis 11.6
9 colitis 11.1
10 diarrhea 10.9
11 maxillary sinusitis 10.5 RNASE3 MPO
12 hemorrhoid 10.5 NOS2 MMP9
13 inflammatory bowel disease 10.5
14 ulcerative colitis 10.5
15 autoimmune inner ear disease 10.5 MPO MMP9
16 inner ear disease 10.5 MPO MMP9
17 vernal keratoconjunctivitis 10.5 RNASE3 MMP9
18 chronic maxillary sinusitis 10.5 RNASE3 MPO
19 henoch-schoenlein purpura 10.4 RNASE3 MPO
20 mycetoma 10.4 NOS2 MMP9
21 celiac disease 1 10.4
22 periodontosis 10.4 MPO MMP9
23 churg-strauss syndrome 10.4 RNASE3 MPO
24 autoimmune disease 10.4
25 crohn's disease 10.4
26 spastic entropion 10.3 MMP9 MMP1
27 chronic actinic dermatitis 10.3 MMP9 MMP1
28 light chain deposition disease 10.3 MMP9 MMP1
29 chromoblastomycosis 10.3 MMP9 MMP1
30 adult astrocytic tumour 10.3 MMP9 MMP1
31 gastritis 10.2
32 intracranial primitive neuroectodermal tumor 10.2 SCG2 CHGA
33 signet ring cell adenocarcinoma 10.2 COL14A1 CHGA
34 appendicitis 10.2 MPO MMP9
35 protein-losing enteropathy 10.2
36 adrenal medulla cancer 10.2 SCG2 CHGA
37 crohn's colitis 10.2
38 arthritis 10.2
39 respiratory system disease 10.2 RNASE3 MPO MMP9
40 chronic venous insufficiency 10.2 MMP9 MMP1
41 venous insufficiency 10.2 MMP9 MMP1
42 hypertensive heart disease 10.1 MMP9 MMP1
43 glucagonoma 10.1 CHGB CHGA
44 lung disease 10.1 RNASE3 MPO MMP9
45 conjunctivitis 10.1 RNASE3 EPX
46 clostridium difficile colitis 10.1
47 pyoderma 10.1
48 intestinal disease 10.1
49 pyoderma gangrenosum 10.1
50 lupus erythematosus 10.1

Graphical network of the top 20 diseases related to Collagenous Colitis:



Diseases related to Collagenous Colitis
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Symptoms & Phenotypes for Collagenous Colitis

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MGI Mouse Phenotypes related to Collagenous Colitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.02 CHGA COL14A1 MMP9 MPO NOS2
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Drugs & Therapeutics for Collagenous Colitis

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Drugs for Collagenous Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifaximin Approved, Investigational Phase 3 80621-81-4 46783403 6436173
2
Budesonide Approved Phase 2, Phase 3 51333-22-3 63006 5281004
3 Analgesics Phase 3
4 Mesalamine Phase 3 89-57-6
5 Analgesics, Non-Narcotic Phase 3
6 Anti-Inflammatory Agents, Non-Steroidal Phase 3
7 Antirheumatic Agents Phase 3
8 Gastrointestinal Agents Phase 3
9 Anti-Bacterial Agents Phase 3
10 Anti-Infective Agents Phase 3
11 Hormone Antagonists Phase 2, Phase 3
12 Hormones Phase 2, Phase 3
13 Peripheral Nervous System Agents Phase 2, Phase 3
14 Anti-Inflammatory Agents Phase 2, Phase 3
15 glucocorticoids Phase 2, Phase 3
16 Respiratory System Agents Phase 2, Phase 3
17 Anti-Asthmatic Agents Phase 2, Phase 3
18 Autonomic Agents Phase 2, Phase 3
19 Bronchodilator Agents Phase 2, Phase 3
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
21 Pharmaceutical Solutions
22 Cola
23 Antacids
24
Bismuth 7440-69-9 16682734 105143
25 Anti-Ulcer Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long-Term Treatment of Collagenous Colitis With Budesonide. Prospective, Doubleblind Placebo-Controlled Trial. Unknown status NCT00139165 Phase 3 Budesonide
2 Efficacy and Safety of Budesonide in Maintenance Treatment of Collagenous Colitis Completed NCT00180076 Phase 3 Budesonide
3 Double-blind, Double-dummy, Randomised, Placebo-controlled, Multi-centre Phase III Clinical Study on the Efficacy and Tolerability of Budesonide Capsules vs. Mesalazine Granules vs. Placebo for Patients With Collagenous Colitis. Completed NCT00450086 Phase 3 Budesonide;Mesalazine;Placebo
4 Double-blind, Randomised, Placebo-controlled, Multi-centre Phase III Clinical Study on the Efficacy and Tolerability of Budesonide Capsules Versus Placebo for Maintenance of Remission in Patients With Collagenous Colitis Completed NCT01278082 Phase 3 Budesonide;Placebo
5 Rifaximin-treatment of Collagenous Colitis: Not yet recruiting NCT03658993 Phase 3 Rifaximin 550 MG
6 A Randomized, Double-Blind, Placebo Controlled Trial of Budesonide for the Treatment of Active Lymphocytic Colitis Terminated NCT00217022 Phase 2, Phase 3 Budesonide
7 Prospective Study on the Usefulness of Chromoendoscopy in Detecting Microscopic Colitis in Patients Undergoing Colonoscopy Due to Chronic Watery Diarrhoea Unknown status NCT01504048
8 Risk Factors for Microscopic Colitis: A Dutch Case-Control Study Completed NCT01928667
9 Identification and Characterization of Microbial and Immunologic Changes in Microscopic Colitis Recruiting NCT03063957
10 Treatment of Microscopic Colitis (Collagenous Colitis and Lymphocytic Colitis) With Budesonide, Bismuth or Fiber Terminated NCT00184171 Budesonide;Bismuth;Fiber

Search NIH Clinical Center for Collagenous Colitis

Cochrane evidence based reviews: colitis, collagenous

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Genetic Tests for Collagenous Colitis

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Anatomical Context for Collagenous Colitis

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MalaCards organs/tissues related to Collagenous Colitis:

41
Colon, T Cells, Small Intestine, Neutrophil, Endothelial, Heart, Kidney
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Publications for Collagenous Colitis

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Articles related to Collagenous Colitis:

(show top 50) (show all 950)
# Title Authors PMID Year
1
Steroids reduce local inflammatory mediator secretion and mucosal permeability in collagenous colitis patients. 9 38
17109497 2006
2
Budesonide treatment and expression of inducible nitric oxide synthase mRNA in colonic mucosa in collagenous colitis. 9 38
16957516 2006
3
Chronic diarrhoea in non collagenous microscopic colitis: therapeutic effect of cholestyramine. 9 38
15641395 2004
4
Constitutive expression of inducible nitric oxide synthase in the normal human colonic epithelium. 9 38
12229970 2002
5
Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis. 9 38
11511561 2001
6
Evidence of local eosinophil activation and altered mucosal permeability in collagenous colitis. 9 38
11330429 2001
7
Budesonide treatment for microscopic colitis: systematic review and meta-analysis. 38
31211724 2019
8
The Gut Microbiota in Collagenous Colitis Shares Characteristics With Inflammatory Bowel Disease-Associated Dysbiosis. 38
31343467 2019
9
Effects of subspecialty signout and group consensus on the diagnosis of microscopic colitis. 38
31359149 2019
10
Immune-Related Adverse Events in the Gastrointestinal Tract: Diagnostic Utility of Upper Gastrointestinal Biopsies. 38
31361907 2019
11
A nationwide cohort study of the incidence of microscopic colitis in Sweden. 38
30983010 2019
12
Development of collagenous colitis in inflammatory bowel disease: two case reports and a review of the literature. 38
31217987 2019
13
Expression Profiling of Inflammatory and Immunological Genes in Collagenous Colitis. 38
31131860 2019
14
A case of spontaneous colonic perforation in collagenous colitis. 38
31152255 2019
15
Collagenous colitis diagnosed by endoscopically induced mucosal tears. 38
31110073 2019
16
Microscopic colitis: pathophysiology and clinical management. 38
30860066 2019
17
An altered composition of the microbiome in microscopic colitis is driven towards the composition in healthy controls by treatment with budesonide. 38
31009268 2019
18
Microscopic colitis: a narrative review with clinical approach. 38
30486642 2019
19
Vedolizumab in Refractory Microscopic Colitis: An International Case Series. 38
30329034 2019
20
Collagenous colitis without diarrhoea at diagnosis - a follow up study. 38
30782025 2019
21
Collagenous colitis development occurs after long standing mucosal healing in IBD with TNF-α inhibitors, and could be due to exaggerated healing response from excess TNF-α inhibition. 38
30696605 2019
22
Eosinophilic colitis and colonic eosinophilia. 38
30480590 2019
23
Management of microscopic colitis: challenges and solutions. 38
30881078 2019
24
Cancer risk in microscopic colitis: a retrospective cohort study. 38
30611218 2019
25
Validating microscopic colitis (MC) in Swedish pathology registers. 38
30600733 2018
26
Bismuth Toxicity Presenting as Declining Mobility and Falls. 38
30595782 2018
27
Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders. 38
30366790 2018
28
Microscopic colitis: a population-based case series over a 9-year period in Northern Ireland. 38
29742325 2018
29
Moyamoya complicated by thrombotic cerebrovascular accident in a Caucasian woman with collagenous colitis. 38
30094527 2018
30
Associations of Microscopic Colitis With Other Lymphocytic Disorders of the Gastrointestinal Tract. 38
29535059 2018
31
[Neuroendocrine hiperplasia in linfocitic and ulcerative colitis]. 38
30860505 2018
32
Vedolizumab for refractory collagenous colitis: Another piece of the puzzle. 38
30115575 2018
33
Significant association between the use of different proton pump inhibitors and microscopic colitis: a nationwide Danish case-control study. 38
30039564 2018
34
Pediatric Collagenous Gastritis and Colitis: A Case Series and Review of the Literature. 38
29601434 2018
35
Comparative genomics of Campylobacter concisus: Analysis of clinical strains reveals genome diversity and pathogenic potential. 38
29946138 2018
36
Microscopic colitis in Denmark and Sweden: incidence, putative risk factors, histological assessment and endoscopic activity. 38
29852792 2018
37
Spontaneous Tear After Insufflation: A Unique Finding of Collagenous Colitis. 38
28864270 2018
38
Prevalence, Pathogenesis, Diagnosis, and Management of Microscopic Colitis. 38
28669150 2018
39
Microscopic colitis in patients with ulcerative colitis or Crohn's disease: a retrospective observational study and review of the literature. 38
29546806 2018
40
Vedolizumab as a Novel Treatment for Refractory Collagenous Colitis: A Case Report. 38
29610507 2018
41
Smoking is Associated with an Increased Risk of Microscopic Colitis: Results From Two Large Prospective Cohort Studies of US Women. 38
29370359 2018
42
The subtypes of microscopic colitis from a pathologist's perspective: past, present and future. 38
29610757 2018
43
Fatigue and its associated factors in microscopic colitis. 38
30228831 2018
44
[Microscopic Colitis]. 38
30376775 2018
45
Biopsy diagnosis of colitis: an algorithmic approach. 38
29177895 2018
46
Genetic Variation and Gene Expression Levels of Tight Junction Genes Indicates Relationships Between PTEN as well as MAGI1 and Microscopic Colitis. 38
29204743 2018
47
Evaluation by MR Enterocolonography of Lansoprazole-induced Collagenous Colitis Accompanied with Protein-losing Enteropathy. 38
29033425 2018
48
High prevalence of irritable bowel syndrome-type symptoms in microscopic colitis: implications for treatment. 38
29977339 2018
49
Chronic Colitis in Biopsy Samples: Is It Inflammatory Bowel Disease or Something Else? 38
29103536 2017
50
Interventions for treating collagenous colitis. 38
29127772 2017
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Variations for Collagenous Colitis

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Expression for Collagenous Colitis

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Search GEO for disease gene expression data for Collagenous Colitis.
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Pathways for Collagenous Colitis

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Pathways related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.54 RNASE3 NOS2 MPO MMP9 MMP1 EPX
2
Colorectal Cancer Metastasis 64
11.65 NOS2 MMP9 MMP1
3
Interleukin-4 and 13 signaling 66
11.19 NOS2 MMP9 MMP1
4
Hepatitis C and Hepatocellular Carcinoma 1
11.16 NOS2 MMP1
5
amb2 Integrin signaling 1
11.11 MPO MMP9
6
Cell adhesion_Cell-matrix glycoconjugates 22
10.96 MMP9 MMP1
7
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
10.85 MMP9 MMP1
8
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 10.6 NOS2 MMP9 MMP1
9
Syndecan-1-mediated signaling events 1
10.39 MMP9 MMP1
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GO Terms for Collagenous Colitis

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Cellular components related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 SCG2 RNASE3 MPO MMP9 EPX COL14A1
2 extracellular matrix GO:0031012 9.5 MMP9 MMP1 COL14A1
3 secretory granule GO:0030141 9.46 SCG2 MPO CHGB CHGA
4 endoplasmic reticulum lumen GO:0005788 9.43 SCG2 COL14A1 CHGB
5 extracellular region GO:0005576 9.28 SCG2 RNASE3 MPO MMP9 MMP1 EPX

Biological processes related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.63 NOS2 MMP9 MMP1
2 cellular protein metabolic process GO:0044267 9.58 SCG2 MMP1 CHGB
3 antimicrobial humoral response GO:0019730 9.48 RNASE3 CHGA
4 neutrophil degranulation GO:0043312 9.46 RNASE3 MPO MMP9 EPX
5 collagen catabolic process GO:0030574 9.43 MMP9 MMP1
6 defense response to fungus GO:0050832 9.37 MPO CHGA
7 hydrogen peroxide catabolic process GO:0042744 9.32 MPO EPX
8 innate immune response in mucosa GO:0002227 9.26 RNASE3 NOS2
9 defense response to Gram-negative bacterium GO:0050829 9.13 RNASE3 NOS2 CHGA
10 defense response to bacterium GO:0042742 9.02 RNASE3 NOS2 MPO EPX CHGA

Molecular functions related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 8.96 MPO EPX
2 heme binding GO:0020037 8.8 NOS2 MPO EPX
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Sources for Collagenous Colitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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