MCID: CLL021
MIFTS: 43

Collagenous Colitis

Categories: Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Collagenous Colitis

MalaCards integrated aliases for Collagenous Colitis:

Name: Collagenous Colitis 12 76 53 55 15
Colitis, Collagenous 44 73
Microscopic Colitis, Collagenous Type 53

Classifications:



External Ids:

Disease Ontology 12 DOID:0060183
ICD10 33 K52.89
MeSH 44 D046729
NCIt 50 C27021
SNOMED-CT 68 19311003
UMLS 73 C0238067

Summaries for Collagenous Colitis

NIH Rare Diseases : 53 Collagenous colitis is a type of inflammatory bowel disease that affects the colon. It is a form of microscopic colitis, which means that the inflammation is only visible when a biopsy is examined under a microscope; the inflammation cannot be seen or diagnosed from colonoscopy or sigmoidoscopy. Signs and symptoms may be ongoing or intermittent and may include chronic, watery, non-bloody diarrhea and abdominal pain or cramps. The exact underlying cause is unknown but may relate to a bacteria, a virus, an autoimmune response, and/or a genetic predisposition. Treatment for collagenous colitis varies depending on the symptoms and severity in each individual. In some cases, the condition resolves on its own.

MalaCards based summary : Collagenous Colitis, also known as colitis, collagenous, is related to lymphocytic colitis and proctitis. An important gene associated with Collagenous Colitis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Innate Immune System and Hepatitis C and Hepatocellular Carcinoma. The drugs Budesonide and Anti-Asthmatic Agents have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A colitis characterized by a distinctive thickening of the subepithelial collagen table.

Wikipedia : 76 Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak... more...

Related Diseases for Collagenous Colitis

Diseases related to Collagenous Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 lymphocytic colitis 32.3 CD79A CHGA
2 proctitis 29.0 EPX MPO RNASE3
3 food allergy 28.5 EPX RNASE3
4 inflammatory bowel disease 27.7 CHGA EPX MMP1 MPO NOS2
5 microscopic colitis 11.3
6 collagenous gastritis 11.3
7 colitis 10.9
8 churg-strauss syndrome 10.5 MPO RNASE3
9 intracranial primitive neuroectodermal tumor 10.4 CHGA SCG2
10 internal hemorrhoid 10.4 MMP1 NOS2
11 chronic interstitial cystitis 10.4 CD79A RNASE3
12 anisakiasis 10.4 CD79A RNASE3
13 cow milk allergy 10.3 CD79A RNASE3
14 glucagonoma 10.3 CHGA CHGB
15 autoinflammation, lipodystrophy, and dermatosis syndrome 10.3 MPO NOS2 RNASE3
16 monoclonal paraproteinemia 10.3 CD79A MPO
17 carcinoid tumors, intestinal 10.3 CHGA CHGB
18 gastrointestinal allergy 10.3 CD79A RNASE3
19 odontogenic myxoma 10.3 COL14A1 MMP1
20 mucositis 10.3
21 rapidly progressive glomerulonephritis 10.3 CD79A MPO
22 hypersensitivity vasculitis 10.3 CD79A MPO
23 goodpasture syndrome 10.3 CD79A MPO
24 acute proliferative glomerulonephritis 10.3 CD79A MPO
25 bronchopneumonia 10.2 CD79A MPO
26 conjunctival disease 10.2 CD79A RNASE3
27 hypersensitivity reaction type iii disease 10.2 CD79A MPO
28 vulvitis 10.2 CD79A MPO
29 mixed ductal-endocrine carcinoma 10.2 CHGA CHGB
30 periodontosis 10.2 CD79A MPO
31 milk allergy 10.2 CD79A RNASE3
32 ulcerative stomatitis 10.2 CD79A MPO
33 pulmonary hemosiderosis 10.2 CD79A MPO
34 ulcerative colitis 10.2
35 arthritis 10.2
36 eosinophilic granuloma 10.1 EPX RNASE3
37 ocular cicatricial pemphigoid 10.1 CD79A RNASE3
38 diarrhea 10.1
39 inflammatory bowel disease 4 10.1 EPX RNASE3
40 conjunctival nevus 10.1 EPX RNASE3
41 eosinophilic gastroenteritis 10.1 EPX RNASE3
42 nose disease 10.1 CD79A RNASE3
43 eosinophil peroxidase deficiency 10.1 EPX MPO
44 pulmonary disease, chronic obstructive 10.1 MMP1 MPO RNASE3
45 parasitic helminthiasis infectious disease 10.1 CD79A RNASE3
46 chronic rhinitis 10.0 EPX MPO
47 urinary schistosomiasis 10.0 EPX RNASE3
48 protein-losing enteropathy 10.0
49 upper respiratory tract disease 10.0 CD79A RNASE3
50 maxillary sinusitis 10.0 CD79A MPO RNASE3

Graphical network of the top 20 diseases related to Collagenous Colitis:



Diseases related to Collagenous Colitis

Symptoms & Phenotypes for Collagenous Colitis

GenomeRNAi Phenotypes related to Collagenous Colitis according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.66 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.66 CD79A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.66 CHGA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.66 CHGA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.66 MPO
6 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.66 MPO
7 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.66 CHGA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.66 CHGA MPO
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.66 CD79A
10 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.66 CHGA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.66 MPO
12 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.66 CHGA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.66 MPO
14 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.66 MPO
15 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.66 MPO
16 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.66 CD79A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.66 MPO
18 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.66 MPO CD79A CHGA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.66 CD79A

Drugs & Therapeutics for Collagenous Colitis

Drugs for Collagenous Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 3,Not Applicable 51333-22-3 63006 5281004
2 Anti-Asthmatic Agents Phase 3,Not Applicable
3 Anti-Inflammatory Agents Phase 3,Not Applicable
4 Autonomic Agents Phase 3,Not Applicable
5 Bronchodilator Agents Phase 3,Not Applicable
6 glucocorticoids Phase 3,Not Applicable
7 Hormone Antagonists Phase 3,Not Applicable
8 Hormones Phase 3,Not Applicable
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Not Applicable
10 Peripheral Nervous System Agents Phase 3,Not Applicable
11 Respiratory System Agents Phase 3,Not Applicable
12 Analgesics Phase 3
13 Analgesics, Non-Narcotic Phase 3
14 Anti-Inflammatory Agents, Non-Steroidal Phase 3
15 Antirheumatic Agents Phase 3
16 Mesalamine Phase 3 89-57-6
17 Pharmaceutical Solutions Not Applicable
18 Antacids Not Applicable
19 Anti-Ulcer Agents Not Applicable
20
Bismuth Not Applicable 7440-69-9 16682734 105143
21 Gastrointestinal Agents Not Applicable
22 Cola Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long-Term Treatment of Collagenous Colitis With Budesonide Unknown status NCT00139165 Phase 3 Budesonide
2 Budesonide for Maintenance Treatment of Collagenous Colitis Completed NCT00180076 Phase 3 Budesonide
3 Budesonide Capsules vs. Mesalazine Granules vs. Placebo in Collagenous Colitis Completed NCT00450086 Phase 3 Budesonide;Mesalazine;Placebo
4 SOIBD Collagenous Colitis Maintenance Study Completed NCT01278082 Phase 3 Budesonide;Placebo
5 Usefulness of Chromoendoscopy in Diagnosing Microscopic Colitis Unknown status NCT01504048 Not Applicable
6 Case-Control Study to Identify Risk Factors for Microscopic Colitis Completed NCT01928667
7 Treatment of Microscopic Colitis Terminated NCT00184171 Not Applicable Budesonide;Bismuth;Fiber

Search NIH Clinical Center for Collagenous Colitis

Cochrane evidence based reviews: colitis, collagenous

Genetic Tests for Collagenous Colitis

Anatomical Context for Collagenous Colitis

MalaCards organs/tissues related to Collagenous Colitis:

41
Colon, Small Intestine, T Cells, Endothelial, Kidney, Heart, Liver

Publications for Collagenous Colitis

Articles related to Collagenous Colitis:

(show top 50) (show all 450)
# Title Authors Year
1
Evaluation by MR Enterocolonography of Lansoprazole-induced Collagenous Colitis Accompanied with Protein-losing Enteropathy. ( 29033425 )
2018
2
Vedolizumab as a Novel Treatment for Refractory Collagenous Colitis: A Case Report. ( 29610507 )
2018
3
Interventions for treating collagenous colitis. ( 29127772 )
2017
4
Proton pump inhibitor induced collagen expression in colonocytes is associated with collagenous colitis. ( 28321159 )
2017
5
Acute onset collagenous colitis associated with protein-losing enteropathy. ( 29264009 )
2017
6
Magnifying image-enhanced endoscopy for collagenous colitis. ( 29250581 )
2017
7
Magnifying advanced endoscopy in collagenous colitis: now you see? ( 29250582 )
2017
8
A case of collagenous colitis associated with novel oral anticoagulants use. ( 28260714 )
2017
9
Collagenous colitis presenting with skip lesions mimicking Crohn's disease and complicated by intestinal obstruction. ( 28682012 )
2017
10
Spontaneous Tear after Insufflation: A Unique Finding of Collagenous Colitis. ( 28864270 )
2017
11
Macroscopic findings in collagenous colitis: a multi-center, retrospective, observational cohort study. ( 28469361 )
2017
12
Collagenous colitis: Requirement for high-dose budesonide as maintenance treatment. ( 28457904 )
2017
13
Clinical and immunologic effects of faecal microbiota transplantation in a patient with collagenous colitis. ( 28275312 )
2017
14
Anti-PD1-induced collagenous colitis in a melanoma patient. ( 26990271 )
2016
15
Elevated fecal levels of eosinophil granule proteins predict collagenous colitis in patients referred to colonoscopy due to chronic non-bloody diarrhea. ( 26854205 )
2016
16
Pseudomembranes Carpet the Right Colon as a Result of Collagenous Colitis. ( 27725290 )
2016
17
Comparison of Clinical Features, Treatment and Outcomes of Collagenous Sprue, Celiac Disease and Collagenous Colitis. ( 27620860 )
2016
18
Pseudomembranous Collagenous Colitis: A Case of Not-so-Microscopic Colitis. ( 28119938 )
2016
19
Tofacitinib Response in Juvenile Idiopathic Arthritis (JIA) and Collagenous Colitis. ( 27870773 )
2016
20
Smoking Status Influences Clinical Outcome in Collagenous Colitis. ( 26721941 )
2016
21
Spontaneous colonic perforation: a rare complication of collagenous colitis. ( 27178398 )
2016
22
Automated image analysis in the study of collagenous colitis. ( 27114713 )
2016
23
Optimal management of collagenous colitis: a review. ( 26929656 )
2016
24
Collagenous colitis and Crohn's disease: Guilty or innocent bystander? ( 27474197 )
2016
25
Letter: oral low-dose methotrexate for collagenous colitis. ( 27250588 )
2016
26
Collagenous colitis presenting as spontaneous perforation in an 80A year old woman: Report of a Case. ( 27716080 )
2016
27
Letter: oral low-dose methotrexate for collagenous colitis - authors' reply. ( 27250589 )
2016
28
Immunological Differences between Lymphocytic and Collagenous Colitis. ( 26928959 )
2016
29
Collagenous Colitis Refractory to Budesonide: is the Upper Gastrointestinal Tract Involved? ( 27557639 )
2016
30
Collagenous Colitis Associated with Protein-losing Enteropathy. ( 26568022 )
2015
31
Dense genotyping of immune-related loci identifies HLA variants associated with increased risk of collagenous colitis. ( 26525574 )
2015
32
Fecal stream diversion and mucosal cytokine levels in collagenous colitis: A case report. ( 26019474 )
2015
33
Severe acute kidney injury as a complication of collagenous colitis. ( 26561416 )
2015
34
P171. Smoking is associated with watery diarrhea and decreased likelihood to achieve clinical remission in collagenous colitis. ( 25717636 )
2015
35
Microscopic (collagenous) colitis in a patient with a heart transplant. ( 26115392 )
2015
36
Increased Production of Lysozyme Associated with Bacterial Proliferation in Barrett's Esophagitis, Chronic Gastritis, Gluten-induced Atrophic Duodenitis (Celiac Disease), Lymphocytic Colitis, Collagenous Colitis, Ulcerative Colitis and Crohn's Colitis. ( 26637845 )
2015
37
DOP082. Genome-wide association identifies multiple collagenous colitis susceptibility loci. ( 25718298 )
2015
38
Collagenous Colitis Associated with Rabeprazole in a Peritoneal Dialysis Patient. ( 26450480 )
2015
39
Collagenous colitis with mucosal ulcerations in a patient without nonsteroidal anti-inflammatory drug or lansoprazole use. ( 26130218 )
2015
40
Pseudomembranous variant of collagenous colitis. ( 26508688 )
2015
41
Mucosal tears and colonic perforation in a patient with collagenous colitis. ( 24523187 )
2014
42
Acute onset collagenous colitis with unique endoscopic findings. ( 25610672 )
2014
43
O-018a88genome-wide association identifies multiple collagenous colitis susceptibility Loci. ( 25407172 )
2014
44
Efficacy of budesonide in collagenous colitis Evaluation of: Miehlke S, Madisch A, Kupcinskas L, et al. Budesonide is more effective than mesalamine or placebo in short-term treatment of collagenous colitis. Gastroenterology 2014;146(5):1222-1230 e1222. ( 25164577 )
2014
45
Budesonide is more effective than mesalamine or placebo in short-term treatment of collagenous colitis. ( 24440672 )
2014
46
Low-dose budesonide for maintenance of clinical remission in collagenous colitis: a randomised, placebo-controlled, 12-month trial. ( 25425655 )
2014
47
Collagenous colitis during treatment with fumaric acid esters. ( 25482705 )
2014
48
Collagenous colitis in systemic sclerosis: an overlooked and treatable complication. ( 25036565 )
2014
49
Clinical characteristics of collagenous colitis with linear ulcerations. ( 23560988 )
2014
50
Pseudomembranous collagenous colitis: an unusual cause of chronic diarrhoea. ( 24526204 )
2014

Variations for Collagenous Colitis

Expression for Collagenous Colitis

Search GEO for disease gene expression data for Collagenous Colitis.

Pathways for Collagenous Colitis

Pathways related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.76 CD79A CHGA EPX MMP1 MPO NOS2
2 10.66 MMP1 NOS2

GO Terms for Collagenous Colitis

Cellular components related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 CHGA COL14A1 EPX MPO RNASE3 SCG2
2 extracellular region GO:0005576 9.56 CHGA CHGB COL14A1 EPX MMP1 MPO
3 endoplasmic reticulum lumen GO:0005788 9.43 CHGB COL14A1 SCG2
4 secretory granule GO:0030141 8.92 CHGA CHGB MPO SCG2

Biological processes related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.54 CHGB MMP1 SCG2
2 antimicrobial humoral response GO:0019730 9.4 CHGA RNASE3
3 defense response to fungus GO:0050832 9.32 CHGA MPO
4 innate immune response in mucosa GO:0002227 9.26 NOS2 RNASE3
5 hydrogen peroxide catabolic process GO:0042744 9.16 EPX MPO
6 defense response to Gram-negative bacterium GO:0050829 9.13 CHGA NOS2 RNASE3
7 defense response to bacterium GO:0042742 9.02 CHGA EPX MPO NOS2 RNASE3

Molecular functions related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 8.96 EPX MPO
2 heme binding GO:0020037 8.8 EPX MPO NOS2

Sources for Collagenous Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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