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MCID: CLL021
MIFTS: 42

Collagenous Colitis

Categories: Gastrointestinal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Collagenous Colitis

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MalaCards integrated aliases for Collagenous Colitis:

Name: Collagenous Colitis 12 74 52 54 15 17
Colitis, Collagenous 43 71
Microscopic Colitis, Collagenous Type 52

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060183
MeSH 43 D046729
NCIt 49 C27021
SNOMED-CT 67 19311003
ICD10 32 K52.831
UMLS 71 C0238067
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Summaries for Collagenous Colitis

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NIH Rare Diseases : 52 Collagenous colitis is a type of inflammatory bowel disease that affects the colon . It is a form of microscopic colitis , which causes chronic diarrhea. It typically occurs in middle-aged adults, is more common in females than in males, and has rarely been reported in children. In all forms of microscopic colitis, the colon appears normal or almost normal on colonoscopy , but the inflammation is visible when a biopsy of the colon is examined under a microscope (hence its name). Signs and symptoms include chronic, watery, non-bloody diarrhea that may begin suddenly or worsen over time. People with this disease usually have between four and nine watery bowel movements per day, but in rare cases may have more than fifteen. Various other symptoms relating to the gastrointestinal system or other body symptoms may also be present. The cause of collagenous colitis is not known but it is thought to be multifactorial. This means that both genetic and environmental factors may interact to cause a person to develop the disease. The extent to which genes play a role is unclear, but familial cases have been described. Certain medications, such as NSAIDS and proton pump inhibitors , have been reported to cause or trigger the disease in some people. However, strong evidence directly linking these medications to the disease is still lacking. The main goal of treatment is to lessen the number of bowel movements per day and improve quality of life. Treatment depends on the symptoms and severity in each person and may involve avoiding or discontinuing medications that may be associated with the disease, taking anti-diarrheal medications, budesonide , or other medications. Surgery to remove all or part of the colon may be needed in severe cases that do not respond to other treatments. In some cases, diarrhea resolves within weeks (with or without treatment), but relapses are common.

MalaCards based summary : Collagenous Colitis, also known as colitis, collagenous, is related to lymphocytic colitis and pyoderma. An important gene associated with Collagenous Colitis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Rifaximin and Budesonide have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and heart, and related phenotypes are cardiovascular system and homeostasis/metabolism

Disease Ontology : 12 A colitis characterized by a distinctive thickening of the subepithelial collagen table.

Wikipedia : 74 Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak... more...

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Related Diseases for Collagenous Colitis

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Diseases related to Collagenous Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 258)
# Related Disease Score Top Affiliating Genes
1 lymphocytic colitis 31.2 MMP9 CLDN4 CHGA
2 pyoderma 30.0 NOD2 MMP9 MMP1
3 pyoderma gangrenosum 30.0 NOD2 MMP9 MMP1
4 proteasome-associated autoinflammatory syndrome 1 29.8 RNASE3 NOS2 MPO MMP9
5 proctitis 29.7 RNASE3 MPO EPX
6 pelvic organ prolapse 29.6 TIMP1 MMP9 MMP1
7 hypereosinophilic syndrome 29.5 RNASE3 MPO EPX
8 pulmonary fibrosis 29.3 TIMP1 MPO MMP9 CCN2
9 rheumatoid arthritis 29.0 TIMP1 NOS2 MPO MMP9 MMP1 CD40LG
10 inflammatory bowel disease 27.9 TIMP1 NOS2 NOD2 MPO MMP9 MMP1
11 obsolete: collagenous colitis 12.4
12 microscopic colitis 11.7
13 collagenous gastritis 11.6
14 colitis 11.1
15 diarrhea 10.9
16 ulcerative colitis 10.5
17 adhesive otitis media 10.5 RNASE3 MPO
18 chronic maxillary sinusitis 10.5 RNASE3 MPO
19 internal hemorrhoid 10.4 NOS2 MMP9
20 hemorrhoid 10.4 NOS2 MMP9
21 celiac disease 1 10.4
22 auditory system cancer 10.4 MMP9 CHGA
23 mycetoma 10.4 NOS2 MMP9
24 autoimmune disease 10.4
25 fungal keratitis 10.4 TIMP1 MMP9
26 crohn's disease 10.3
27 erythema elevatum diutinum 10.3 MPO CD40LG
28 appendix lymphoma 10.3 MPO CHGA
29 glucagonoma 10.3 CHGB CHGA
30 middle ear carcinoma 10.3 MMP9 CHGA
31 carcinoid tumors, intestinal 10.3 CHGB CHGA
32 gallbladder small cell carcinoma 10.3 CHGB CHGA
33 mononeuritis of upper limb and mononeuritis multiplex 10.3 MPO CD40LG
34 borderline leprosy 10.3 NOS2 CD40LG
35 mononeuritis multiplex 10.3 MPO CD40LG
36 subacute bacterial endocarditis 10.3 MPO CD40LG
37 chronic actinic dermatitis 10.3 MMP9 MMP1
38 scleral disease 10.3 MPO CD40LG
39 spastic entropion 10.2 MMP9 MMP1
40 toxocariasis 10.2 RNASE3 CD40LG
41 light chain deposition disease 10.2 MMP9 MMP1
42 gastritis 10.2
43 vasomotor rhinitis 10.2 RNASE3 CD40LG
44 baritosis 10.2 TIMP1 NOS2 MPO
45 autoimmune inner ear disease 10.2 TIMP1 MPO MMP9
46 inner ear disease 10.2 TIMP1 MPO MMP9
47 crohn's colitis 10.2
48 protein-losing enteropathy 10.2
49 maxillary sinusitis 10.2 RNASE3 MPO CD40LG
50 henoch-schoenlein purpura 10.2 RNASE3 MPO CD40LG

Graphical network of the top 20 diseases related to Collagenous Colitis:



Diseases related to Collagenous Colitis
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Symptoms & Phenotypes for Collagenous Colitis

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MGI Mouse Phenotypes related to Collagenous Colitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.81 CCN2 CD40LG CHGA CLDN4 MMP9 MPO
2 homeostasis/metabolism MP:0005376 9.73 CCN2 CD40LG CHGA CHGB CLDN4 EPX
3 skeleton MP:0005390 9.23 CCN2 CD40LG COL14A1 EPX MMP9 NOD2
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Drugs & Therapeutics for Collagenous Colitis

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Drugs for Collagenous Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifaximin Approved, Investigational Phase 3 80621-81-4 6436173 46783403
2
Budesonide Approved Phase 2, Phase 3 51333-22-3 63006 5281004
3 Analgesics Phase 3
4 Mesalamine Phase 3 89-57-6
5 Analgesics, Non-Narcotic Phase 3
6 Anti-Inflammatory Agents, Non-Steroidal Phase 3
7 Antirheumatic Agents Phase 3
8 Gastrointestinal Agents Phase 3
9 Anti-Bacterial Agents Phase 3
10 Anti-Infective Agents Phase 3
11 Anti-Asthmatic Agents Phase 2, Phase 3
12 Anti-Inflammatory Agents Phase 2, Phase 3
13 Respiratory System Agents Phase 2, Phase 3
14 Hormone Antagonists Phase 2, Phase 3
15 Autonomic Agents Phase 2, Phase 3
16 Bronchodilator Agents Phase 2, Phase 3
17 glucocorticoids Phase 2, Phase 3
18 Hormones Phase 2, Phase 3
19 Pharmaceutical Solutions
20 Cola
21 Anti-Ulcer Agents
22
Bismuth 7440-69-9 16682734 105143
23 Antacids

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long-Term Treatment of Collagenous Colitis With Budesonide. Prospective, Doubleblind Placebo-Controlled Trial. Unknown status NCT00139165 Phase 3 Budesonide
2 Efficacy and Safety of Budesonide in Maintenance Treatment of Collagenous Colitis Completed NCT00180076 Phase 3 Budesonide
3 Double-blind, Double-dummy, Randomised, Placebo-controlled, Multi-centre Phase III Clinical Study on the Efficacy and Tolerability of Budesonide Capsules vs. Mesalazine Granules vs. Placebo for Patients With Collagenous Colitis. Completed NCT00450086 Phase 3 Budesonide;Mesalazine;Placebo
4 Double-blind, Randomised, Placebo-controlled, Multi-centre Phase III Clinical Study on the Efficacy and Tolerability of Budesonide Capsules Versus Placebo for Maintenance of Remission in Patients With Collagenous Colitis Completed NCT01278082 Phase 3 Budesonide;Placebo
5 Rifaximin-treatment of Collagenous Colitis: Not yet recruiting NCT03658993 Phase 3 Rifaximin 550 MG
6 A Randomized, Double-Blind, Placebo Controlled Trial of Budesonide for the Treatment of Active Lymphocytic Colitis Terminated NCT00217022 Phase 2, Phase 3 Budesonide
7 Prospective Study on the Usefulness of Chromoendoscopy in Detecting Microscopic Colitis in Patients Undergoing Colonoscopy Due to Chronic Watery Diarrhoea Unknown status NCT01504048
8 Risk Factors for Microscopic Colitis: A Dutch Case-Control Study Completed NCT01928667
9 Identification and Characterization of Microbial and Immunologic Changes in Microscopic Colitis Recruiting NCT03063957
10 Treatment of Microscopic Colitis (Collagenous Colitis and Lymphocytic Colitis) With Budesonide, Bismuth or Fiber Terminated NCT00184171 Budesonide;Bismuth;Fiber

Search NIH Clinical Center for Collagenous Colitis

Cochrane evidence based reviews: colitis, collagenous

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Genetic Tests for Collagenous Colitis

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Anatomical Context for Collagenous Colitis

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MalaCards organs/tissues related to Collagenous Colitis:

40
Colon, T Cells, Heart, Thyroid, Bone, Lung, Small Intestine
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Publications for Collagenous Colitis

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Articles related to Collagenous Colitis:

(show top 50) (show all 956)
# Title Authors PMID Year
1
Steroids reduce local inflammatory mediator secretion and mucosal permeability in collagenous colitis patients. 54 61
17109497 2006
2
Budesonide treatment and expression of inducible nitric oxide synthase mRNA in colonic mucosa in collagenous colitis. 54 61
16957516 2006
3
Chronic diarrhoea in non collagenous microscopic colitis: therapeutic effect of cholestyramine. 54 61
15641395 2004
4
Constitutive expression of inducible nitric oxide synthase in the normal human colonic epithelium. 54 61
12229970 2002
5
Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis. 54 61
11511561 2001
6
Evidence of local eosinophil activation and altered mucosal permeability in collagenous colitis. 54 61
11330429 2001
7
The water channel aquaporin 8 is a critical regulator of intestinal fluid homeostasis in collagenous colitis. 61
32016376 2020
8
Treatment of microscopic colitis: the role of budesonide and new alternatives for refractory patients. 61
31880163 2020
9
Immune-related adverse events in the gastrointestinal tract: diagnostic utility of upper gastrointestinal biopsies. 61
31361907 2020
10
Beclomethasone dipropionate in microscopic colitis: Results of an exploratory open-label multicentre study (COLCO). 61
31700631 2019
11
Effects of subspecialty signout and group consensus on the diagnosis of microscopic colitis. 61
31359149 2019
12
Cancer Risk in Collagenous Colitis. 61
31718057 2019
13
Clinicopathological significance of lymphocytic colitis/collagenous colitis in inflammatory bowel disease. 61
31698005 2019
14
Wavy mucosal tear in the sigmoid colon. 61
31534768 2019
15
Budesonide treatment for microscopic colitis: systematic review and meta-analysis. 61
31211724 2019
16
The Gut Microbiota in Collagenous Colitis Shares Characteristics With Inflammatory Bowel Disease-Associated Dysbiosis. 61
31343467 2019
17
Development of collagenous colitis in inflammatory bowel disease: two case reports and a review of the literature. 61
31217987 2019
18
A nationwide cohort study of the incidence of microscopic colitis in Sweden. 61
30983010 2019
19
Expression Profiling of Inflammatory and Immunological Genes in Collagenous Colitis. 61
31131860 2019
20
A case of spontaneous colonic perforation in collagenous colitis. 61
31152255 2019
21
Collagenous colitis diagnosed by endoscopically induced mucosal tears. 61
31110073 2019
22
Microscopic colitis: pathophysiology and clinical management. 61
30860066 2019
23
An altered composition of the microbiome in microscopic colitis is driven towards the composition in healthy controls by treatment with budesonide. 61
31009268 2019
24
Microscopic colitis: a narrative review with clinical approach. 61
30486642 2019
25
Vedolizumab in Refractory Microscopic Colitis: An International Case Series. 61
30329034 2019
26
Collagenous colitis without diarrhoea at diagnosis - a follow up study. 61
30782025 2019
27
Collagenous colitis development occurs after long standing mucosal healing in IBD with TNF-α inhibitors, and could be due to exaggerated healing response from excess TNF-α inhibition. 61
30696605 2019
28
Cancer risk in microscopic colitis: a retrospective cohort study. 61
30611218 2019
29
Management of microscopic colitis: challenges and solutions. 61
30881078 2019
30
Eosinophilic colitis and colonic eosinophilia. 61
30480590 2019
31
Validating microscopic colitis (MC) in Swedish pathology registers. 61
30600733 2018
32
Bismuth Toxicity Presenting as Declining Mobility and Falls. 61
30595782 2018
33
Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders. 61
30366790 2018
34
Moyamoya complicated by thrombotic cerebrovascular accident in a Caucasian woman with collagenous colitis. 61
30094527 2018
35
Microscopic colitis: a population-based case series over a 9-year period in Northern Ireland. 61
29742325 2018
36
Associations of Microscopic Colitis With Other Lymphocytic Disorders of the Gastrointestinal Tract. 61
29535059 2018
37
Vedolizumab for refractory collagenous colitis: Another piece of the puzzle. 61
30115575 2018
38
[Neuroendocrine hiperplasia in linfocitic and ulcerative colitis]. 61
30860505 2018
39
Pediatric Collagenous Gastritis and Colitis: A Case Series and Review of the Literature. 61
29601434 2018
40
Significant association between the use of different proton pump inhibitors and microscopic colitis: a nationwide Danish case-control study. 61
30039564 2018
41
Microscopic colitis in Denmark and Sweden: incidence, putative risk factors, histological assessment and endoscopic activity. 61
29852792 2018
42
Comparative genomics of Campylobacter concisus: Analysis of clinical strains reveals genome diversity and pathogenic potential. 61
29946138 2018
43
Prevalence, Pathogenesis, Diagnosis, and Management of Microscopic Colitis. 61
28669150 2018
44
Spontaneous Tear After Insufflation: A Unique Finding of Collagenous Colitis. 61
28864270 2018
45
Microscopic colitis in patients with ulcerative colitis or Crohn's disease: a retrospective observational study and review of the literature. 61
29546806 2018
46
Vedolizumab as a Novel Treatment for Refractory Collagenous Colitis: A Case Report. 61
29610507 2018
47
Smoking is Associated with an Increased Risk of Microscopic Colitis: Results From Two Large Prospective Cohort Studies of US Women. 61
29370359 2018
48
The subtypes of microscopic colitis from a pathologist's perspective: past, present and future. 61
29610757 2018
49
Fatigue and its associated factors in microscopic colitis. 61
30228831 2018
50
[Microscopic Colitis]. 61
30376775 2018
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Variations for Collagenous Colitis

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Expression for Collagenous Colitis

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Search GEO for disease gene expression data for Collagenous Colitis.
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Pathways for Collagenous Colitis

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Pathways related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.66 TIMP1 RNASE3 NOS2 NOD2 MPO MMP9
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.04 TIMP1 NOS2 NOD2 MMP9 MMP1 CD40LG
3
Matrix Metalloproteinases 1
Show member pathways
 11.58 TIMP1 MMP9 MMP1
4
Interleukin-4 and 13 signaling 65
11.31 TIMP1 NOS2 MMP9 MMP1
5
Lung fibrosis 1
11.3 TIMP1 MMP9 CCN2
6
Cell adhesion_ECM remodeling 22
11.22 TIMP1 MMP9 MMP1
7
amb2 Integrin signaling 1
11.01 MPO MMP9 CCN2
8
Immune response_Oncostatin M signaling via JAK-Stat in human cells 22
10.76 TIMP1 MMP1
9
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 10.72 NOS2 MMP9 MMP1 CD40LG
10
Syndecan-1-mediated signaling events 1
10.66 MMP9 MMP1
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GO Terms for Collagenous Colitis

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Cellular components related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 TIMP1 SCG2 RNASE3 MPO MMP9 EPX
2 endoplasmic reticulum lumen GO:0005788 9.62 TIMP1 SCG2 COL14A1 CHGB
3 secretory granule GO:0030141 9.56 SCG2 MPO CHGB CHGA
4 extracellular matrix GO:0031012 9.55 TIMP1 MMP9 MMP1 COL14A1 CCN2
5 extracellular region GO:0005576 9.4 TIMP1 SCG2 RNASE3 MPO MMP9 MMP1

Biological processes related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.67 TIMP1 NOS2 MMP9 MMP1
2 cellular protein metabolic process GO:0044267 9.46 TIMP1 SCG2 MMP1 CHGB
3 defense response to Gram-negative bacterium GO:0050829 9.43 RNASE3 NOS2 CHGA
4 positive regulation of interleukin-4 production GO:0032753 9.4 EPX CD40LG
5 positive regulation of cardiac muscle contraction GO:0060452 9.32 CHGA CCN2
6 extracellular matrix disassembly GO:0022617 9.13 TIMP1 MMP9 MMP1
7 defense response to bacterium GO:0042742 9.1 RNASE3 NOS2 NOD2 MPO EPX CHGA

Molecular functions related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.8 NOS2 MPO EPX
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Sources for Collagenous Colitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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