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MCID: CLL021
MIFTS: 42

Collagenous Colitis

Categories: Gastrointestinal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Collagenous Colitis

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MalaCards integrated aliases for Collagenous Colitis:

Name: Collagenous Colitis 12 74 52 54 15 17
Colitis, Collagenous 43 71
Microscopic Colitis, Collagenous Type 52

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060183
MeSH 43 D046729
NCIt 49 C27021
SNOMED-CT 67 19311003
ICD10 32 K52.831
UMLS 71 C0238067
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Summaries for Collagenous Colitis

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NIH Rare Diseases : 52 Collagenous colitis is a type of inflammatory bowel disease that affects the colon . It is a form of microscopic colitis , which causes chronic diarrhea. It typically occurs in middle-aged adults, is more common in females than in males, and has rarely been reported in children. In all forms of microscopic colitis, the colon appears normal or almost normal on colonoscopy , but the inflammation is visible when a biopsy of the colon is examined under a microscope (hence its name). Signs and symptoms include chronic, watery, non-bloody diarrhea that may begin suddenly or worsen over time. People with this disease usually have between four and nine watery bowel movements per day, but in rare cases may have more than fifteen. Various other symptoms relating to the gastrointestinal system or other body symptoms may also be present. The cause of collagenous colitis is not known but it is thought to be multifactorial. This means that both genetic and environmental factors may interact to cause a person to develop the disease. The extent to which genes play a role is unclear, but familial cases have been described. Certain medications, such as NSAIDS and proton pump inhibitors , have been reported to cause or trigger the disease in some people. However, strong evidence directly linking these medications to the disease is still lacking. The main goal of treatment is to lessen the number of bowel movements per day and improve quality of life. Treatment depends on the symptoms and severity in each person and may involve avoiding or discontinuing medications that may be associated with the disease, taking anti-diarrheal medications, budesonide , or other medications. Surgery to remove all or part of the colon may be needed in severe cases that do not respond to other treatments. In some cases, diarrhea resolves within weeks (with or without treatment), but relapses are common.

MalaCards based summary : Collagenous Colitis, also known as colitis, collagenous, is related to lymphocytic colitis and diarrhea. An important gene associated with Collagenous Colitis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Rifaximin and Budesonide have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and small intestine, and related phenotypes are cardiovascular system and homeostasis/metabolism

Disease Ontology : 12 A colitis characterized by a distinctive thickening of the subepithelial collagen table.

Wikipedia : 74 Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak... more...

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Related Diseases for Collagenous Colitis

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Diseases related to Collagenous Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 253)
# Related Disease Score Top Affiliating Genes
1 lymphocytic colitis 31.2 MMP9 CLDN4 CHGA
2 diarrhea 30.9 NOD2 MPO CLDN4 CD40LG
3 pyoderma gangrenosum 30.0 NOD2 MMP9 MMP1
4 proteasome-associated autoinflammatory syndrome 1 29.8 RNASE3 NOS2 MPO MMP9
5 hypereosinophilic syndrome 29.7 RNASE3 MPO EPX
6 pelvic organ prolapse 29.7 TIMP1 MMP9 MMP1
7 pyoderma 29.6 NOD2 MMP9 MMP1 CD40LG
8 proctitis 29.3 RNASE3 NOD2 MPO EPX
9 rheumatoid arthritis 29.1 TIMP1 NOS2 MPO MMP9 MMP1 CD40LG
10 psoriatic arthritis 29.0 NOD2 MMP1 CD40LG
11 pulmonary fibrosis 28.8 TIMP1 MPO MMP9 MMP1 CCN2
12 inflammatory bowel disease 28.1 TIMP1 NOS2 NOD2 MPO MMP9 MMP1
13 microscopic colitis 11.7
14 collagenous gastritis 11.6
15 colitis 11.1
16 ulcerative colitis 10.5
17 chronic maxillary sinusitis 10.4 RNASE3 MPO
18 internal hemorrhoid 10.4 NOS2 MMP9
19 celiac disease 1 10.4
20 hemorrhoid 10.4 NOS2 MMP9
21 auditory system cancer 10.4 MMP9 CHGA
22 mycetoma 10.4 NOS2 MMP9
23 autoimmune disease 10.4
24 prolapse of lacrimal gland 10.4 MMP9 CD40LG
25 allergic cutaneous vasculitis 10.3 MPO CD40LG
26 fungal keratitis 10.3 TIMP1 MMP9
27 crohn's disease 10.3
28 gallbladder small cell carcinoma 10.3 CHGB CHGA
29 chronic actinic dermatitis 10.3 MMP9 MMP1
30 glucagonoma 10.3 CHGB CHGA
31 adhesive otitis media 10.3 RNASE3 MPO
32 viral laryngitis 10.3 RNASE3 CD40LG
33 carcinoid tumors, intestinal 10.3 CHGB CHGA
34 spastic entropion 10.3 MMP9 MMP1
35 borderline leprosy 10.3 NOS2 CD40LG
36 anisakiasis 10.3 RNASE3 CD40LG
37 light chain deposition disease 10.3 MMP9 MMP1
38 mononeuritis of upper limb and mononeuritis multiplex 10.3 MPO CD40LG
39 mononeuritis multiplex 10.3 MPO CD40LG
40 subacute bacterial endocarditis 10.3 MPO CD40LG
41 aortitis 10.3 MPO CD40LG
42 mastoiditis 10.2 MPO CD40LG
43 gastritis 10.2
44 toxocariasis 10.2 RNASE3 CD40LG
45 baritosis 10.2 TIMP1 NOS2 MPO
46 crohn's colitis 10.2
47 protein-losing enteropathy 10.2
48 autoimmune inner ear disease 10.2 TIMP1 MPO MMP9
49 inner ear disease 10.2 TIMP1 MPO MMP9
50 peritoneal serous adenocarcinoma 10.2 CLDN4 CHGA

Graphical network of the top 20 diseases related to Collagenous Colitis:



Diseases related to Collagenous Colitis
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Symptoms & Phenotypes for Collagenous Colitis

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MGI Mouse Phenotypes related to Collagenous Colitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.81 CCN2 CD40LG CHGA CLDN4 MMP9 MPO
2 homeostasis/metabolism MP:0005376 9.73 CCN2 CD40LG CHGA CHGB CLDN4 EPX
3 skeleton MP:0005390 9.23 CCN2 CD40LG COL14A1 EPX MMP9 NOD2
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Drugs & Therapeutics for Collagenous Colitis

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Drugs for Collagenous Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifaximin Approved, Investigational Phase 3 80621-81-4 6436173 46783403
2
Budesonide Approved Phase 2, Phase 3 51333-22-3 63006 5281004
3 Mesalamine Phase 3 89-57-6
4 Analgesics, Non-Narcotic Phase 3
5 Analgesics Phase 3
6 Antirheumatic Agents Phase 3
7 Anti-Inflammatory Agents, Non-Steroidal Phase 3
8 Gastrointestinal Agents Phase 3
9 Anti-Bacterial Agents Phase 3
10 Anti-Infective Agents Phase 3
11 Respiratory System Agents Phase 2, Phase 3
12 Hormones Phase 2, Phase 3
13 Anti-Asthmatic Agents Phase 2, Phase 3
14 Hormone Antagonists Phase 2, Phase 3
15 glucocorticoids Phase 2, Phase 3
16 Bronchodilator Agents Phase 2, Phase 3
17 Anti-Inflammatory Agents Phase 2, Phase 3
18 Pharmaceutical Solutions
19 Cola
20 Antacids
21 Anti-Ulcer Agents
22
Bismuth 7440-69-9 16682734 105143

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long-Term Treatment of Collagenous Colitis With Budesonide. Prospective, Doubleblind Placebo-Controlled Trial. Unknown status NCT00139165 Phase 3 Budesonide
2 Efficacy and Safety of Budesonide in Maintenance Treatment of Collagenous Colitis Completed NCT00180076 Phase 3 Budesonide
3 Double-blind, Double-dummy, Randomised, Placebo-controlled, Multi-centre Phase III Clinical Study on the Efficacy and Tolerability of Budesonide Capsules vs. Mesalazine Granules vs. Placebo for Patients With Collagenous Colitis. Completed NCT00450086 Phase 3 Budesonide;Mesalazine;Placebo
4 Double-blind, Randomised, Placebo-controlled, Multi-centre Phase III Clinical Study on the Efficacy and Tolerability of Budesonide Capsules Versus Placebo for Maintenance of Remission in Patients With Collagenous Colitis Completed NCT01278082 Phase 3 Budesonide;Placebo
5 Rifaximin-treatment of Collagenous Colitis: Not yet recruiting NCT03658993 Phase 3 Rifaximin 550 MG
6 A Randomized, Double-Blind, Placebo Controlled Trial of Budesonide for the Treatment of Active Lymphocytic Colitis Terminated NCT00217022 Phase 2, Phase 3 Budesonide
7 Prospective Study on the Usefulness of Chromoendoscopy in Detecting Microscopic Colitis in Patients Undergoing Colonoscopy Due to Chronic Watery Diarrhoea Unknown status NCT01504048
8 Risk Factors for Microscopic Colitis: A Dutch Case-Control Study Completed NCT01928667
9 Identification and Characterization of Microbial and Immunologic Changes in Microscopic Colitis Recruiting NCT03063957
10 Treatment of Microscopic Colitis (Collagenous Colitis and Lymphocytic Colitis) With Budesonide, Bismuth or Fiber Terminated NCT00184171 Budesonide;Bismuth;Fiber

Search NIH Clinical Center for Collagenous Colitis

Cochrane evidence based reviews: colitis, collagenous

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Genetic Tests for Collagenous Colitis

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Anatomical Context for Collagenous Colitis

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MalaCards organs/tissues related to Collagenous Colitis:

40
Colon, T Cells, Small Intestine, Endothelial, Neutrophil, Heart, Kidney
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Publications for Collagenous Colitis

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Articles related to Collagenous Colitis:

(show top 50) (show all 970)
# Title Authors PMID Year
1
Steroids reduce local inflammatory mediator secretion and mucosal permeability in collagenous colitis patients. 61 54
17109497 2006
2
Budesonide treatment and expression of inducible nitric oxide synthase mRNA in colonic mucosa in collagenous colitis. 54 61
16957516 2006
3
Chronic diarrhoea in non collagenous microscopic colitis: therapeutic effect of cholestyramine. 54 61
15641395 2004
4
Constitutive expression of inducible nitric oxide synthase in the normal human colonic epithelium. 61 54
12229970 2002
5
Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis. 54 61
11511561 2001
6
Evidence of local eosinophil activation and altered mucosal permeability in collagenous colitis. 54 61
11330429 2001
7
Incidence and prevalence of microscopic colitis between 2001 and 2016: A Danish nationwide cohort study. 61
32502240 2020
8
COLLAGENOUS COLITIS IS ASSOCIATED WITH HLA SIGNATURE AND SHARES GENETIC RISKS WITH OTHER IMMUNE-MEDIATED DISEASES. 61
32371109 2020
9
Anti-PD-1 induced collagenous colitis in metastatic melanoma: a rare severe adverse event. 61
32404733 2020
10
An investigation of European pathologists' approach to diagnose microscopic colitis. 61
32278285 2020
11
Gastrointestinal Malakoplakia: Clinicopathologic Analysis of 26 Cases. 61
32301754 2020
12
The association between smoking and both types of microscopic colitis: A systematic review and meta-analysis. 61
32241698 2020
13
High risk of microscopic colitis after Campylobacter concisus infection: population-based cohort study. 61
32111632 2020
14
Biopsies From Ascending and Descending Colon Are Sufficient for Diagnosis of Microscopic Colitis. 61
32109628 2020
15
The water channel aquaporin 8 is a critical regulator of intestinal fluid homeostasis in collagenous colitis. 61
32016376 2020
16
[An unusual digestive complication under anti-PD-1 (pembrolizumab)]. 61
32107038 2020
17
Clinicopathological significance of lymphocytic colitis/collagenous colitis in inflammatory bowel disease. 61
31698005 2020
18
Comorbid Occurrence of Eosinophilic Esophagitis and Inflammatory Bowel Disease. 61
32068153 2020
19
Undiagnosed microscopic colitis: a hidden cause of chronic diarrhoea and a frequently missed treatment opportunity. 61
32419914 2020
20
Increased Mast Cell Counts and Degranulation in Microscopic Colitis. 61
32148478 2020
21
Faecal Calprotectin and 7-α Cholestenone Levels in Microscopic Colitis: Experience from Edinburgh. 61
32440188 2020
22
Pediatric Collagenous Gastroenterocolitis Successfully Treated with Methotrexate. 61
32181040 2020
23
Immune-related adverse events in the gastrointestinal tract: diagnostic utility of upper gastrointestinal biopsies. 61
31361907 2020
24
Treatment of microscopic colitis: the role of budesonide and new alternatives for refractory patients. 61
31880163 2020
25
Beclomethasone dipropionate in microscopic colitis: Results of an exploratory open-label multicentre study (COLCO). 61
31700631 2019
26
Effects of subspecialty signout and group consensus on the diagnosis of microscopic colitis. 61
31359149 2019
27
Cancer Risk in Collagenous Colitis. 61
31718057 2019
28
Wavy mucosal tear in the sigmoid colon. 61
31534768 2019
29
Budesonide treatment for microscopic colitis: systematic review and meta-analysis. 61
31211724 2019
30
The Gut Microbiota in Collagenous Colitis Shares Characteristics With Inflammatory Bowel Disease-Associated Dysbiosis. 61
31343467 2019
31
Development of collagenous colitis in inflammatory bowel disease: two case reports and a review of the literature. 61
31217987 2019
32
A nationwide cohort study of the incidence of microscopic colitis in Sweden. 61
30983010 2019
33
Expression Profiling of Inflammatory and Immunological Genes in Collagenous Colitis. 61
31131860 2019
34
Collagenous colitis diagnosed by endoscopically induced mucosal tears. 61
31110073 2019
35
A case of spontaneous colonic perforation in collagenous colitis. 61
31152255 2019
36
Microscopic colitis: pathophysiology and clinical management. 61
30860066 2019
37
An altered composition of the microbiome in microscopic colitis is driven towards the composition in healthy controls by treatment with budesonide. 61
31009268 2019
38
Vedolizumab in Refractory Microscopic Colitis: An International Case Series. 61
30329034 2019
39
Microscopic colitis: a narrative review with clinical approach. 61
30486642 2019
40
Collagenous colitis without diarrhoea at diagnosis - a follow up study. 61
30782025 2019
41
Collagenous colitis development occurs after long standing mucosal healing in IBD with TNF-α inhibitors, and could be due to exaggerated healing response from excess TNF-α inhibition. 61
30696605 2019
42
Eosinophilic colitis and colonic eosinophilia. 61
30480590 2019
43
Management of microscopic colitis: challenges and solutions. 61
30881078 2019
44
Cancer risk in microscopic colitis: a retrospective cohort study. 61
30611218 2019
45
Validating microscopic colitis (MC) in Swedish pathology registers. 61
30600733 2018
46
Bismuth Toxicity Presenting as Declining Mobility and Falls. 61
30595782 2018
47
Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders. 61
30366790 2018
48
Microscopic colitis: a population-based case series over a 9-year period in Northern Ireland. 61
29742325 2018
49
Moyamoya complicated by thrombotic cerebrovascular accident in a Caucasian woman with collagenous colitis. 61
30094527 2018
50
Associations of Microscopic Colitis With Other Lymphocytic Disorders of the Gastrointestinal Tract. 61
29535059 2018
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Variations for Collagenous Colitis

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Expression for Collagenous Colitis

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Search GEO for disease gene expression data for Collagenous Colitis.
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Pathways for Collagenous Colitis

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Pathways related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.66 TIMP1 RNASE3 NOS2 NOD2 MPO MMP9
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.04 TIMP1 NOS2 NOD2 MMP9 MMP1 CD40LG
3
Matrix Metalloproteinases 1
Show member pathways
 11.58 TIMP1 MMP9 MMP1
4
Interleukin-4 and 13 signaling 65
11.31 TIMP1 NOS2 MMP9 MMP1
5
Lung fibrosis 1
11.3 TIMP1 MMP9 CCN2
6
Cell adhesion_ECM remodeling 22
11.22 TIMP1 MMP9 MMP1
7
amb2 Integrin signaling 1
11.01 MPO MMP9 CCN2
8
Immune response_Oncostatin M signaling via JAK-Stat in human cells 22
10.76 TIMP1 MMP1
9
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 10.72 NOS2 MMP9 MMP1 CD40LG
10
Syndecan-1-mediated signaling events 1
10.66 MMP9 MMP1
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GO Terms for Collagenous Colitis

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Cellular components related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 TIMP1 SCG2 RNASE3 MPO MMP9 EPX
2 endoplasmic reticulum lumen GO:0005788 9.67 TIMP1 SCG2 COL14A1 CHGB
3 extracellular matrix GO:0031012 9.65 TIMP1 MMP9 MMP1 COL14A1 CCN2
4 secretory granule GO:0030141 9.46 SCG2 MPO CHGB CHGA
5 extracellular region GO:0005576 9.4 TIMP1 SCG2 RNASE3 MPO MMP9 MMP1
6 neuronal dense core vesicle GO:0098992 9.32 SCG2 CHGA

Biological processes related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.67 TIMP1 NOS2 MMP9 MMP1
2 defense response to Gram-negative bacterium GO:0050829 9.43 RNASE3 NOS2 CHGA
3 positive regulation of interleukin-4 production GO:0032753 9.4 EPX CD40LG
4 extracellular matrix disassembly GO:0022617 9.33 TIMP1 MMP9 MMP1
5 positive regulation of cardiac muscle contraction GO:0060452 9.32 CHGA CCN2
6 cellular protein metabolic process GO:0044267 9.26 TIMP1 SCG2 MMP1 CHGB
7 defense response to bacterium GO:0042742 9.1 RNASE3 NOS2 NOD2 MPO EPX CHGA

Molecular functions related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.8 NOS2 MPO EPX
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Sources for Collagenous Colitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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