MCID: CLL021
MIFTS: 42

Collagenous Colitis

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Collagenous Colitis

MalaCards integrated aliases for Collagenous Colitis:

Name: Collagenous Colitis 12 74 20 54 15 17
Colitis, Collagenous 44 71
Microscopic Colitis, Collagenous Type 20

Classifications:



External Ids:

Disease Ontology 12 DOID:0060183
MeSH 44 D046729
NCIt 50 C27021
SNOMED-CT 67 19311003
ICD10 32 K52.831
UMLS 71 C0238067

Summaries for Collagenous Colitis

GARD : 20 Collagenous colitis is a type of inflammatory bowel disease that affects the colon. It is a form of microscopic colitis, which causes chronic diarrhea. It typically occurs in middle-aged adults, is more common in females than in males, and has rarely been reported in children. In all forms of microscopic colitis, the colon appears normal or almost normal on colonoscopy, but the inflammation is visible when a biopsy of the colon is examined under a microscope (hence its name). Signs and symptoms include chronic, watery, non-bloody diarrhea that may begin suddenly or worsen over time. People with this disease usually have between four and nine watery bowel movements per day, but in rare cases may have more than fifteen. Various other symptoms relating to the gastrointestinal system or other body symptoms may also be present. The cause of collagenous colitis is not known but it is thought to be multifactorial. This means that both genetic and environmental factors may interact to cause a person to develop the disease. The extent to which genes play a role is unclear, but familial cases have been described. Certain medications, such as NSAIDS and proton pump inhibitors, have been reported to cause or trigger the disease in some people. However, strong evidence directly linking these medications to the disease is still lacking. The main goal of treatment is to lessen the number of bowel movements per day and improve quality of life. Treatment depends on the symptoms and severity in each person and may involve avoiding or discontinuing medications that may be associated with the disease, taking anti-diarrheal medications, budesonide, or other medications. Surgery to remove all or part of the colon may be needed in severe cases that do not respond to other treatments. In some cases, diarrhea resolves within weeks (with or without treatment), but relapses are common.

MalaCards based summary : Collagenous Colitis, also known as colitis, collagenous, is related to lymphocytic colitis and pyoderma. An important gene associated with Collagenous Colitis is RNASE3 (Ribonuclease A Family Member 3), and among its related pathways/superpathways are Innate Immune System and Degradation of the extracellular matrix. The drugs Budesonide and Rifaximin have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and endothelial, and related phenotype is homeostasis/metabolism.

Disease Ontology : 12 A colitis characterized by a distinctive thickening of the subepithelial collagen table.

Wikipedia : 74 Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak... more...

Related Diseases for Collagenous Colitis

Diseases related to Collagenous Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 226)
# Related Disease Score Top Affiliating Genes
1 lymphocytic colitis 31.2 MMP9 CLDN4 CHGA
2 pyoderma 30.3 NOD2 MMP9 MMP1
3 pyoderma gangrenosum 30.3 NOD2 MMP9 MMP1
4 proteasome-associated autoinflammatory syndrome 1 29.9 RNASE3 NOS2 MPO MMP9
5 proctitis 29.9 RNASE3 MPO EPX
6 hypereosinophilic syndrome 29.8 RNASE3 MPO EPX
7 allergic rhinitis 29.4 RNASE3 MPO EPX
8 rheumatoid arthritis 29.0 TIMP1 NOS2 MPO MMP9 MMP1
9 pulmonary fibrosis 29.0 TIMP1 MPO MMP9 MMP1 CCN2
10 inflammatory bowel disease 28.9 TIMP1 NOS2 NOD2 MPO MMP9 MMP1
11 microscopic colitis 11.3
12 colitis 11.2
13 collagenous gastritis 11.2
14 diarrhea 11.0
15 celiac disease 1 10.6
16 ulcerative colitis 10.6
17 crohn's disease 10.4
18 autoimmune disease 10.4
19 protein-losing enteropathy 10.4
20 gastritis 10.4
21 crohn's colitis 10.4
22 chronic maxillary sinusitis 10.3 RNASE3 MPO
23 maxillary sinusitis 10.3 RNASE3 MPO
24 internal hemorrhoid 10.3 NOS2 MMP9
25 hemorrhoid 10.3 NOS2 MMP9
26 adhesive otitis media 10.3 RNASE3 MPO
27 patulous eustachian tube 10.3 RNASE3 MPO
28 mycetoma 10.3 NOS2 MMP9
29 clostridium difficile colitis 10.2
30 intestinal disease 10.2
31 lentigo maligna melanoma 10.2 TIMP1 MMP9
32 anorectal stricture 10.2 NOD2 CLDN4
33 fungal keratitis 10.2 TIMP1 MMP9
34 systemic lupus erythematosus 10.2
35 scleroderma, familial progressive 10.2
36 arthropathy 10.2
37 thyroiditis 10.2
38 duodenitis 10.2
39 irritable bowel syndrome 10.2
40 gallbladder small cell carcinoma 10.2 CHGB CHGA
41 glucagonoma 10.2 CHGB CHGA
42 adrenal neuroblastoma 10.2 CHGB CHGA
43 bronchitis 10.2 RNASE3 MPO MMP9
44 peritoneal serous adenocarcinoma 10.2 CLDN4 CHGA
45 carcinoid tumors, intestinal 10.2 CHGB CHGA
46 spondyloarthropathy 10.1
47 megacolon 10.1
48 inflammatory spondylopathy 10.1
49 common variable immunodeficiency 10.1
50 toxic megacolon 10.1

Graphical network of the top 20 diseases related to Collagenous Colitis:



Diseases related to Collagenous Colitis

Symptoms & Phenotypes for Collagenous Colitis

MGI Mouse Phenotypes related to Collagenous Colitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.4 CCN2 CHGA CHGB CLDN4 COL14A1 EPX

Drugs & Therapeutics for Collagenous Colitis

Drugs for Collagenous Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 3 51333-22-3 63006 5281004
2
Rifaximin Approved, Investigational Phase 3 80621-81-4 6436173 46783403
3 Respiratory System Agents Phase 3
4 Anti-Asthmatic Agents Phase 3
5 Anti-Inflammatory Agents Phase 3
6 Hormone Antagonists Phase 3
7 Hormones Phase 3
8 glucocorticoids Phase 3
9 Bronchodilator Agents Phase 3
10 Mesalamine Phase 3 89-57-6
11 Anti-Inflammatory Agents, Non-Steroidal Phase 3
12 Antirheumatic Agents Phase 3
13 Analgesics, Non-Narcotic Phase 3
14 Analgesics Phase 3
15 Gastrointestinal Agents Phase 3
16 Anti-Infective Agents Phase 3
17 Anti-Bacterial Agents Phase 3
18 Cola
19 Pharmaceutical Solutions
20 Antacids
21 Anti-Ulcer Agents
22
Bismuth 7440-69-9 16682734 105143

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long-Term Treatment of Collagenous Colitis With Budesonide. Prospective, Doubleblind Placebo-Controlled Trial. Unknown status NCT00139165 Phase 3 Budesonide
2 Double-blind, Randomised, Placebo-controlled, Multi-centre Phase III Clinical Study on the Efficacy and Tolerability of Budesonide Capsules Versus Placebo for Maintenance of Remission in Patients With Collagenous Colitis Completed NCT01278082 Phase 3 Budesonide;Placebo
3 Efficacy and Safety of Budesonide in Maintenance Treatment of Collagenous Colitis Completed NCT00180076 Phase 3 Budesonide
4 Double-blind, Double-dummy, Randomised, Placebo-controlled, Multi-centre Phase III Clinical Study on the Efficacy and Tolerability of Budesonide Capsules vs. Mesalazine Granules vs. Placebo for Patients With Collagenous Colitis. Completed NCT00450086 Phase 3 Budesonide;Mesalazine;Placebo
5 Rifaximin-treatment of Collagenous Colitis: Not yet recruiting NCT03658993 Phase 3 Rifaximin 550 MG
6 Prospective Study on the Usefulness of Chromoendoscopy in Detecting Microscopic Colitis in Patients Undergoing Colonoscopy Due to Chronic Watery Diarrhoea Unknown status NCT01504048
7 Risk Factors for Microscopic Colitis: A Dutch Case-Control Study Completed NCT01928667
8 Treatment of Microscopic Colitis (Collagenous Colitis and Lymphocytic Colitis) With Budesonide, Bismuth or Fiber Terminated NCT00184171 Budesonide;Bismuth;Fiber

Search NIH Clinical Center for Collagenous Colitis

Cochrane evidence based reviews: colitis, collagenous

Genetic Tests for Collagenous Colitis

Anatomical Context for Collagenous Colitis

MalaCards organs/tissues related to Collagenous Colitis:

40
Colon, T Cells, Endothelial, Small Intestine, Neutrophil, Heart, Kidney

Publications for Collagenous Colitis

Articles related to Collagenous Colitis:

(show top 50) (show all 985)
# Title Authors PMID Year
1
Steroids reduce local inflammatory mediator secretion and mucosal permeability in collagenous colitis patients. 61 54
17109497 2006
2
Budesonide treatment and expression of inducible nitric oxide synthase mRNA in colonic mucosa in collagenous colitis. 61 54
16957516 2006
3
Chronic diarrhoea in non collagenous microscopic colitis: therapeutic effect of cholestyramine. 61 54
15641395 2004
4
Constitutive expression of inducible nitric oxide synthase in the normal human colonic epithelium. 54 61
12229970 2002
5
Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis. 61 54
11511561 2001
6
Evidence of local eosinophil activation and altered mucosal permeability in collagenous colitis. 61 54
11330429 2001
7
Comorbid Occurrence of Eosinophilic Esophagitis and Inflammatory Bowel Disease. 61
32068153 2021
8
Medication-specific variations in morphological patterns of injury in immune check-point inhibitor-associated colitis. 61
32931028 2021
9
Collagenous colitis and atezolizumab therapy: an atypical case. 61
33151423 2021
10
Novel Case Report: A Previously Reported, but Pathophysiologically Unexplained, Association Between Collagenous Colitis and Protein-Losing Enteropathy May Be Explained by an Undetected Link with Collagenous Duodenitis. 61
33537921 2021
11
Bile Acid Sequestrant Therapy in Microscopic Colitis. 61
33443968 2021
12
Distribution of histopathological features along the colon in microscopic colitis. 61
32920702 2021
13
A case of collagenous colitis with endoscopic changes enhanced by indigo carmine chromoendoscopy. 61
33359259 2020
14
Lymphocytic and collagenous colitis in children and adolescents: Comprehensive clinicopathologic analysis with long-term follow-up. 61
32991931 2020
15
Anti-PD-1 induced collagenous colitis in metastatic melanoma: a rare severe adverse event. 61
32404733 2020
16
Collagenous Colitis Mucosa Is Characterized by an Expansion of Nonsuppressive FoxP3+ T Helper Cells. 61
33319252 2020
17
Faecal microbiota transfer in patients with microscopic colitis - a pilot study in collagenous colitis. 61
33142068 2020
18
Epidemiological and clinical characteristics, and response to treatment in 113 patients with microscopic colitis. 61
33248178 2020
19
High risk of microscopic colitis after Campylobacter concisus infection: population-based cohort study. 61
32111632 2020
20
Increasing Incidence of Microscopic Colitis in a Population-Based Cohort Study in Switzerland. 61
33065310 2020
21
Disease activity patterns, mortality and colorectal cancer risk in microscopic colitis: a Danish nationwide cohort study, 2001 to 2016. 61
33049029 2020
22
Colitis nucleomigrans: The third type of microscopic colitis (part 1). 61
32761850 2020
23
Topographical distribution of microscopic colitis and the importance of orientation of paraffin-embedded biopsies. 61
32673680 2020
24
Cannabidiol Oil-Associated Microscopic Colitis. 61
33094069 2020
25
Gastrointestinal Malakoplakia: Clinicopathologic Analysis of 26 Cases. 61
32301754 2020
26
Biopsies From Ascending and Descending Colon Are Sufficient for Diagnosis of Microscopic Colitis. 61
32109628 2020
27
Campylobacter concisus is prevalent in the gastrointestinal tract of patients with microscopic colitis. 61
32667235 2020
28
European guidelines on microscopic colitis: United European Gastroenterology (UEG) and European Microscopic Colitis Group (EMCG) statements and recommendations. 61
32819215 2020
29
Collagenous Colitis Is Associated With HLA Signature and Shares Genetic Risks With Other Immune-Mediated Diseases. 61
32371109 2020
30
Collagenous colitis in a child induced by chronic respiratory allergy: A case report. 61
32871927 2020
31
All-cause and cause-specific mortality in microscopic colitis: a Danish nationwide matched cohort study. 61
32583929 2020
32
Aquaporin-5 Expression Is Reduced in Lymphocytic Colitis. 61
32826239 2020
33
The Water Channel Aquaporin 8 is a Critical Regulator of Intestinal Fluid Homeostasis in Collagenous Colitis. 61
32016376 2020
34
[An unusual digestive complication under anti-PD-1 (pembrolizumab)]. 61
32107038 2020
35
An investigation of European pathologists' approach to diagnose microscopic colitis. 61
32278285 2020
36
Incidence and prevalence of microscopic colitis between 2001 and 2016: A Danish nationwide cohort study. 61
32502240 2020
37
The association between smoking and both types of microscopic colitis: A systematic review and meta-analysis. 61
32241698 2020
38
Clinicopathological significance of lymphocytic colitis/collagenous colitis in inflammatory bowel disease. 61
31698005 2020
39
Undiagnosed microscopic colitis: a hidden cause of chronic diarrhoea and a frequently missed treatment opportunity. 61
32419914 2020
40
Increased Mast Cell Counts and Degranulation in Microscopic Colitis. 61
32148478 2020
41
Treatment of microscopic colitis: the role of budesonide and new alternatives for refractory patients. 61
31880163 2020
42
Faecal microbiota transplantation in Clostridioides difficile infection: real-life experience from an academic Italian hospital. 61
32774464 2020
43
Pediatric Collagenous Gastroenterocolitis Successfully Treated with Methotrexate. 61
32181040 2020
44
Immune-related adverse events in the gastrointestinal tract: diagnostic utility of upper gastrointestinal biopsies. 61
31361907 2020
45
Faecal Calprotectin and 7-α Cholestenone Levels in Microscopic Colitis: Experience from Edinburgh. 61
32440188 2020
46
Beclomethasone dipropionate in microscopic colitis: Results of an exploratory open-label multicentre study (COLCO). 61
31700631 2019
47
Effects of subspecialty signout and group consensus on the diagnosis of microscopic colitis. 61
31359149 2019
48
Cancer Risk in Collagenous Colitis. 61
31718057 2019
49
Wavy mucosal tear in the sigmoid colon. 61
31534768 2019
50
Budesonide treatment for microscopic colitis: systematic review and meta-analysis. 61
31211724 2019

Variations for Collagenous Colitis

Expression for Collagenous Colitis

Search GEO for disease gene expression data for Collagenous Colitis.

Pathways for Collagenous Colitis

Pathways related to Collagenous Colitis according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 TIMP1 RNASE3 NOS2 NOD2 MPO MMP9
2
Show member pathways
12.43 TIMP1 MMP9 MMP1 COL14A1
3 11.9 NOS2 MMP9 MMP1
4
Show member pathways
11.54 TIMP1 MMP9 MMP1
5
Show member pathways
11.3 NOS2 MMP9 MMP1
6 11.23 TIMP1 MMP9 CCN2
7 11.12 TIMP1 MMP9 MMP1
8 10.98 TIMP1 NOS2 MMP9 MMP1
9 10.89 TIMP1 MMP9
10 10.81 MPO MMP9 CCN2
11 10.74 TIMP1 MMP1
12 10.66 MMP9 MMP1

GO Terms for Collagenous Colitis

Cellular components related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.67 TIMP1 SCG2 COL14A1 CHGB
2 extracellular matrix GO:0031012 9.65 TIMP1 MMP9 MMP1 COL14A1 CCN2
3 extracellular space GO:0005615 9.65 TIMP1 SCG2 RNASE3 MPO MMP9 EPX
4 secretory granule GO:0030141 9.46 SCG2 MPO CHGB CHGA
5 extracellular region GO:0005576 9.36 TIMP1 SCG2 RNASE3 MPO MMP9 MMP1
6 neuronal dense core vesicle GO:0098992 9.32 SCG2 CHGA

Biological processes related to Collagenous Colitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.8 RNASE3 MPO MMP9 EPX
2 cytokine-mediated signaling pathway GO:0019221 9.73 TIMP1 NOS2 MMP9 MMP1
3 response to lipopolysaccharide GO:0032496 9.7 NOS2 NOD2 MPO
4 defense response GO:0006952 9.65 NOD2 MPO EPX
5 defense response to Gram-positive bacterium GO:0050830 9.63 RNASE3 NOD2 CHGA
6 cellular protein metabolic process GO:0044267 9.56 TIMP1 SCG2 MMP1 CHGB
7 defense response to Gram-negative bacterium GO:0050829 9.54 RNASE3 NOS2 CHGA
8 hydrogen peroxide catabolic process GO:0042744 9.51 MPO EPX
9 extracellular matrix disassembly GO:0022617 9.5 TIMP1 MMP9 MMP1
10 positive regulation of cardiac muscle contraction GO:0060452 9.4 CHGA CCN2
11 innate immune response in mucosa GO:0002227 9.33 RNASE3 NOS2 NOD2
12 cellular response to UV-A GO:0071492 9.13 TIMP1 MMP9 MMP1
13 defense response to bacterium GO:0042742 9.1 RNASE3 NOS2 NOD2 MPO EPX CHGA

Molecular functions related to Collagenous Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.8 NOS2 MPO EPX

Sources for Collagenous Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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