Colloid Carcinoma of the Pancreas disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Colloid Carcinoma of the Pancreas

MalaCards integrated aliases for Colloid Carcinoma of the Pancreas:

Name: Colloid Carcinoma of the Pancreas ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7717

NCIt ⁵⁰ C37214

UMLS ⁷² C1333081

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Summaries for Colloid Carcinoma of the Pancreas

MalaCards based summary : Colloid Carcinoma of the Pancreas is related to adenocarcinoma and pseudomyxoma peritonei. An important gene associated with Colloid Carcinoma of the Pancreas is PSCA (Prostate Stem Cell Antigen), and among its related pathways/superpathways are Integrated Breast Cancer Pathway and Diseases of glycosylation. Affiliated tissues include pancreas, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Colloid Carcinoma of the Pancreas

Diseases related to Colloid Carcinoma of the Pancreas via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)

#	Related Disease	Score	Top Affiliating Genes
1	adenocarcinoma	30.3	SMAD4 MUC1 KRAS HRAS
2	pseudomyxoma peritonei	30.2	MUC5AC MUC1 KRAS
3	pancreatic cancer	26.1	SMAD4 PSCA MUC5AC MUC1 MSLN KRT19
4	sigmoid neoplasm	10.5	KRAS HRAS
5	syringocystadenoma papilliferum	10.5	MUC1 KRAS
6	mutyh-associated polyposis	10.5	SMAD4 KRAS
7	paronychia	10.5	KRAS HRAS
8	familial colorectal cancer type x	10.5	SMAD4 BRCA2
9	schimmelpenning-feuerstein-mims syndrome	10.4	KRAS HRAS
10	bile duct cysts	10.4	KRAS HRAS
11	appendix disease	10.4	KRAS HRAS
12	breast mucoepidermoid carcinoma	10.4	MUC5AC MUC1
13	solid adenocarcinoma with mucin production	10.4	MUC5AC MUC1
14	cryptogenic organizing pneumonia	10.4	MUC5B MUC1
15	nasal cavity adenocarcinoma	10.4	KRAS HRAS
16	lung adenoid cystic carcinoma	10.3	KRAS HRAS
17	apocrine adenoma	10.3	MUC1 KRAS HRAS
18	bile duct cystadenocarcinoma	10.3	MUC5AC MUC1
19	aggressive digital papillary adenocarcinoma	10.3	MUC1 KRAS HRAS
20	secondary hypertrophic osteoarthropathy	10.3	KRAS HRAS
21	duodenum cancer	10.3	MUC1 KRAS HRAS
22	ampulla of vater cancer	10.3	MUC1 KRAS HRAS
23	carcinosarcoma	10.3	MUC1 KRAS HRAS
24	pancreas disease	10.3	SMAD4 KRAS HRAS
25	chronic ethmoiditis	10.2	MUC5B MUC5AC MUC1
26	bile duct mucoepidermoid carcinoma	10.2	MUC5B MUC5AC MUC1
27	ethmoid sinusitis	10.2	MUC5B MUC5AC MUC1
28	colorectal cancer 1	10.2	MUC5B MUC5AC MUC1
29	gastric cardia carcinoma	10.2	SMAD4 MUC5AC MUC1
30	anal gland adenocarcinoma	10.2	MUC5AC KRT19
31	malignant struma ovarii	10.2	KRT19 HRAS
32	mucinous ovarian cystadenoma	10.2	MUC5AC MUC1
33	anus adenocarcinoma	10.2	MUC5AC KRT19
34	immune system disease	10.1	MUC5B MUC5AC MUC1
35	filamentary keratitis	10.1	MUC5AC MUC1
36	liver angiosarcoma	10.1	KRT19 KRAS HRAS
37	ovarian cystadenocarcinoma	10.1	KRAS HRAS
38	respiratory system cancer	10.0	KRT19 KRAS HRAS
39	pericardial mesothelioma	10.0	MUC1 MSLN KRT19
40	mucinous tubular and spindle renal cell carcinoma	10.0	MUC1 KRT19
41	large intestine cancer	10.0	SMAD4 MUC1 KRAS HRAS
42	pancreatic mucinous cystadenoma	10.0	MUC5B MUC5AC MUC1 HRAS
43	gastric adenocarcinoma	9.9	SMAD4 MUC1 KRAS HRAS
44	respiratory system disease	9.9	MUC5B MUC5AC KRAS HRAS
45	ampulla of vater adenocarcinoma	9.9	MUC1 BRCA2
46	gastrointestinal system cancer	9.8	SMAD4 KRT19 KRAS HRAS
47	adenoid cystic carcinoma	9.8	MUC1 KRT19 KRAS HRAS
48	cyclosporiasis	9.8	GGT2 GGT1
49	algoneurodystrophy	9.7	GGT2 GGT1
50	intrahepatic cholangiocarcinoma	9.7	MUC5AC MUC1 KRT19 KRAS

Graphical network of the top 20 diseases related to Colloid Carcinoma of the Pancreas:

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Symptoms & Phenotypes for Colloid Carcinoma of the Pancreas

GenomeRNAi Phenotypes related to Colloid Carcinoma of the Pancreas according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-2	9.47	HRAS KRAS MUC1
2	Decreased viability	GR00106-A-0	9.47	KRAS
3	Decreased viability	GR00221-A-1	9.47	HRAS KRAS
4	Decreased viability	GR00221-A-2	9.47	HRAS KRAS
5	Decreased viability	GR00221-A-3	9.47	HRAS
6	Decreased viability	GR00301-A	9.47	KRAS
7	Decreased viability	GR00381-A-1	9.47	KRAS
8	Decreased viability	GR00402-S-2	9.47	HRAS KRAS MUC1

MGI Mouse Phenotypes related to Colloid Carcinoma of the Pancreas:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	10.03	BRCA2 HRAS KRAS KRT19 MUC5AC PHEX
2	immune system	MP:0005387	10.02	BRCA2 GGT1 KRAS MUC5AC MUC5B PHEX
3	endocrine/exocrine gland	MP:0005379	10.01	BRCA2 GGT1 HRAS KRAS KRT19 PHEX
4	integument	MP:0010771	9.87	BRCA2 GGT1 HRAS KRAS KRT19 SFN
5	limbs/digits/tail	MP:0005371	9.73	BRCA2 GGT1 KRAS PHEX SFN SMAD4
6	neoplasm	MP:0002006	9.7	BRCA2 HRAS KRAS KRT19 PSCA SFN
7	normal	MP:0002873	9.5	BRCA2 HRAS KRAS KRT19 MSLN PSCA
8	skeleton	MP:0005390	9.23	BRCA2 GGT1 HRAS KRAS KRT19 PHEX

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Drugs & Therapeutics for Colloid Carcinoma of the Pancreas

Search Clinical Trials , NIH Clinical Center for Colloid Carcinoma of the Pancreas

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Genetic Tests for Colloid Carcinoma of the Pancreas

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Anatomical Context for Colloid Carcinoma of the Pancreas

MalaCards organs/tissues related to Colloid Carcinoma of the Pancreas:

⁴¹

Pancreas

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Publications for Colloid Carcinoma of the Pancreas

Articles related to Colloid Carcinoma of the Pancreas:

(show all 11)

#	Title	Authors	PMID	Year
1	Colloid Carcinoma of the Pancreas: Case Report and Review of the Literature. ³⁸	Orcutt ST...Hodul PJ	30631814	2016
2	Colloid carcinoma of the pancreas: a distinct pancreatic neoplasm with good prognosis. Report of a case. ³⁸	Rubio-Perez I...Larranaga E	22406606	2012
3	[Colloid carcinoma of pancreas: a clinicopathologic study of 4 cases]. ³⁸	Chang XY...Chen J	22336159	2011
4	Colloid carcinoma of the pancreas. ³⁸	Plerhoples TA...Poultsides GA	21253833	2011
5	CT features of colloid carcinomas of the pancreas. ³⁸	Ren FY...Lu JP	20529590	2010
6	MRI features of pancreatic colloid carcinoma. ³⁸	Yoon MA...Lee MW	19770300	2009
7	Colloid carcinoma of the pancreas: review of selected pathological and clinical aspects. ³⁸	Liszka L...Golka D	18985519	2008
8	Ductal neoplasia of the pancreas: nosologic, clinicopathologic, and biologic aspects. ³⁸	Adsay NV...Andea AA	16183479	2005
9	Pathologic quiz case: a 52-year-old woman with jaundice and history of necrotizing pancreatitis. Primary colloid carcinoma of the pancreas. ³⁸	Parwani AV...Ali SZ	15679436	2005
10	Pseudomyxoma peritonei associated with colloid carcinoma of the pancreas. ³⁸	Chejfec G...Gould VE	2998918	1986
11	Colloid carcinoma of the pancreas. ³⁸	MUIR EG	12987655	1952

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Genes for Colloid Carcinoma of the Pancreas

Genes related to Colloid Carcinoma of the Pancreas (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PSCA	Prostate Stem Cell Antigen	Protein Coding	14.68	DISEASES inferred ¹⁵
2	PHEX	Phosphate Regulating Endopeptidase Homolog X-Linked	Protein Coding	14.5	DISEASES inferred ¹⁵
3	MUC5B	Mucin 5B, Oligomeric Mucus/Gel-Forming	Protein Coding	14.46	DISEASES inferred ¹⁵
4	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	14.27	DISEASES inferred ¹⁵
5	SMAD4	SMAD Family Member 4	Protein Coding	13.64	DISEASES inferred ¹⁵
6	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	13.6	DISEASES inferred ¹⁵
7	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	13.42	DISEASES inferred ¹⁵
8	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	13.07	DISEASES inferred ¹⁵
9	SFN	Stratifin	Protein Coding	4.6	DISEASES inferred ¹⁵
10	MSLN	Mesothelin	Protein Coding	4.3	DISEASES inferred ¹⁵
11	MUC5AC	Mucin 5AC, Oligomeric Mucus/Gel-Forming	Protein Coding	3.83	DISEASES inferred ¹⁵
12	GGTLC3	Gamma-Glutamyltransferase Light Chain Family Member 3	Protein Coding	3.7	DISEASES inferred ¹⁵
13	GGT2	Gamma-Glutamyltransferase 2	Protein Coding	3.7	DISEASES inferred ¹⁵
14	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	3.67	DISEASES inferred ¹⁵
15	KRT19	Keratin 19	Protein Coding	3.51	DISEASES inferred ¹⁵

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Variations for Colloid Carcinoma of the Pancreas

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Expression for Colloid Carcinoma of the Pancreas

Search GEO for disease gene expression data for Colloid Carcinoma of the Pancreas.

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Pathways for Colloid Carcinoma of the Pancreas

Pathways related to Colloid Carcinoma of the Pancreas according to GeneCards Suite gene sharing:

(show all 16)

#	Super pathways	Score	Top Affiliating Genes
1	Integrated Breast Cancer Pathway ¹	11.92	SMAD4 KRAS BRCA2
2	Diseases of glycosylation ⁶⁶ Show member pathways Diseases associated with O-glycosylation of proteins ⁶⁶	11.85	MUC5B MUC5AC MUC1
3	Signaling pathways regulating pluripotency of stem cells ³⁷	11.8	SMAD4 KRAS HRAS
4	FoxO signaling pathway ³⁷ Show member pathways PLK2 and PLK4 events ¹ Polo-like kinase signaling events in the cell cycle ¹	11.77	SMAD4 KRAS HRAS
5	Apelin signaling pathway ³⁷	11.75	SMAD4 KRAS HRAS
6	DNA Damage Response (only ATM dependent) ¹	11.6	SMAD4 KRAS HRAS
7	MAP Kinase Signaling ⁴	11.55	SFN KRAS HRAS
8	CLEC7A (Dectin-1) signaling ⁶⁶ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁶ C-type lectin receptors (CLRs) ⁶⁶	11.43	MUC5B MUC5AC MUC1 KRAS HRAS
9	AGE-RAGE signaling pathway in diabetic complications ³⁷	11.33	SMAD4 KRAS HRAS
10	Eicosanoid Synthesis ¹	10.93	GGT2 GGT1
11	MNAR-PELP1 and Estrogen Receptor Interaction ⁶⁴	10.9	KRAS HRAS
12	Aflatoxin activation and detoxification ⁶⁶	10.89	GGT2 GGT1
13	CD209 (DC-SIGN) signaling ⁶⁶	10.84	KRAS HRAS
14	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling ¹	10.71	KRAS HRAS
15	Extracellular vesicle-mediated signaling in recipient cells ¹	10.61	SMAD4 KRAS HRAS
16	p38MAPK events ⁶⁶	10.37	KRAS HRAS

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GO Terms for Colloid Carcinoma of the Pancreas

Cellular components related to Colloid Carcinoma of the Pancreas according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.85	PSCA PHEX MUC5B MUC5AC MUC1 MSLN
2	extracellular exosome	GO:0070062	9.28	SFN PSCA MUC5B MUC5AC MUC1 KRT19
3	Golgi lumen	GO:0005796	9.13	MUC5B MUC5AC MUC1

Biological processes related to Colloid Carcinoma of the Pancreas according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	female gonad development	GO:0008585	9.54	SMAD4 BRCA2
2	regulation of long-term neuronal synaptic plasticity	GO:0048169	9.52	KRAS HRAS
3	O-glycan processing	GO:0016266	9.5	MUC5B MUC5AC MUC1
4	zymogen activation	GO:0031638	9.49	GGT2 GGT1
5	response to estradiol	GO:0032355	9.48	GGT2 GGT1
6	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	9.46	MUC1 BRCA2
7	response to isolation stress	GO:0035900	9.4	KRAS HRAS
8	regulation of immune system process	GO:0002682	9.37	GGT2 GGT1
9	glutathione catabolic process	GO:0006751	9.33	GGTLC3 GGT2 GGT1
10	peptide modification	GO:0031179	9.26	GGT2 GGT1
11	glutamate metabolic process	GO:0006536	9.21	GGT1
12	cysteine biosynthetic process	GO:0019344	9.13	GGT1
13	leukotriene D4 biosynthetic process	GO:1901750	9.13	GGTLC3 GGT2 GGT1
14	stimulatory C-type lectin receptor signaling pathway	GO:0002223	9.02	MUC5B MUC5AC MUC1 KRAS HRAS

Molecular functions related to Colloid Carcinoma of the Pancreas according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptidyltransferase activity	GO:0000048	8.96	GGT2 GGT1
2	glutathione hydrolase activity	GO:0036374	8.8	GGTLC3 GGT2 GGT1

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