Colloid Carcinoma of the Pancreas disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Colloid Carcinoma of the Pancreas

MalaCards integrated aliases for Colloid Carcinoma of the Pancreas:

Name: Colloid Carcinoma of the Pancreas ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7717

NCIt ⁵¹ C37214

UMLS ⁷⁴ C1333081

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Summaries for Colloid Carcinoma of the Pancreas

MalaCards based summary : Colloid Carcinoma of the Pancreas is related to pseudomyxoma peritonei and sigmoid neoplasm. An important gene associated with Colloid Carcinoma of the Pancreas is PSCA (Prostate Stem Cell Antigen), and among its related pathways/superpathways are Development EGFR signaling pathway and Integrated Breast Cancer Pathway. Affiliated tissues include pancreas, lung and liver, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Colloid Carcinoma of the Pancreas

Diseases related to Colloid Carcinoma of the Pancreas via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)

#	Related Disease	Score	Top Affiliating Genes
1	pseudomyxoma peritonei	30.1	KRAS MUC1 MUC5AC
2	sigmoid neoplasm	10.3	HRAS KRAS
3	syringocystadenoma papilliferum	10.3	KRAS MUC1
4	paronychia	10.3	HRAS KRAS
5	familial colorectal cancer type x	10.3	BRCA2 SMAD4
6	mutyh-associated polyposis	10.3	KRAS SMAD4
7	schimmelpenning-feuerstein-mims syndrome	10.3	HRAS KRAS
8	bile duct cysts	10.3	HRAS KRAS
9	cryptogenic organizing pneumonia	10.3	MUC1 MUC5B
10	breast mucoepidermoid carcinoma	10.3	MUC1 MUC5AC
11	solid adenocarcinoma with mucin production	10.2	MUC1 MUC5AC
12	appendix disease	10.2	HRAS KRAS
13	lung adenoid cystic carcinoma	10.2	HRAS KRAS
14	nasal cavity adenocarcinoma	10.2	HRAS KRAS
15	apocrine adenoma	10.2	HRAS KRAS MUC1
16	bile duct cystadenocarcinoma	10.2	MUC1 MUC5AC
17	aggressive digital papillary adenocarcinoma	10.2	HRAS KRAS MUC1
18	duodenum cancer	10.2	HRAS KRAS MUC1
19	ampulla of vater cancer	10.2	HRAS KRAS MUC1
20	secondary hypertrophic osteoarthropathy	10.2	HRAS KRAS
21	carcinosarcoma	10.2	HRAS KRAS MUC1
22	bile duct mucoepidermoid carcinoma	10.2	MUC1 MUC5AC MUC5B
23	chronic ethmoiditis	10.2	MUC1 MUC5AC MUC5B
24	pancreas disease	10.2	HRAS KRAS SMAD4
25	ethmoid sinusitis	10.2	MUC1 MUC5AC MUC5B
26	colorectal cancer 1	10.1	MUC1 MUC5AC MUC5B
27	gastric cardia carcinoma	10.1	MUC1 MUC5AC SMAD4
28	anal gland adenocarcinoma	10.1	KRT19 MUC5AC
29	mucinous ovarian cystadenoma	10.1	MUC1 MUC5AC
30	ampulla of vater adenocarcinoma	10.1	BRCA2 MUC1
31	anus adenocarcinoma	10.1	KRT19 MUC5AC
32	immune system disease	10.1	MUC1 MUC5AC MUC5B
33	malignant struma ovarii	10.1	HRAS KRT19
34	filamentary keratitis	10.1	MUC1 MUC5AC
35	adenocarcinoma	10.1	HRAS KRAS MUC1 SMAD4
36	liver angiosarcoma	10.0	HRAS KRAS KRT19
37	ovarian cystadenocarcinoma	10.0	HRAS KRAS
38	respiratory system cancer	10.0	HRAS KRAS KRT19
39	pericardial mesothelioma	10.0	KRT19 MSLN MUC1
40	large intestine cancer	10.0	HRAS KRAS MUC1 SMAD4
41	pancreatic mucinous cystadenoma	10.0	HRAS MUC1 MUC5AC MUC5B
42	gastric adenocarcinoma	10.0	HRAS KRAS MUC1 SMAD4
43	respiratory system disease	9.9	HRAS KRAS MUC5AC MUC5B
44	gastrointestinal system cancer	9.9	HRAS KRAS KRT19 SMAD4
45	adenoid cystic carcinoma	9.9	HRAS KRAS KRT19 MUC1
46	cyclosporiasis	9.9	GGT1 GGT2
47	algoneurodystrophy	9.8	GGT1 GGT2
48	intrahepatic cholangiocarcinoma	9.8	KRAS KRT19 MUC1 MUC5AC
49	mucinous tubular and spindle renal cell carcinoma	9.8	KRT19 MUC1
50	squamous cell carcinoma	9.8	HRAS KRT19 MUC1 SMAD4

Graphical network of the top 20 diseases related to Colloid Carcinoma of the Pancreas:

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Symptoms & Phenotypes for Colloid Carcinoma of the Pancreas

GenomeRNAi Phenotypes related to Colloid Carcinoma of the Pancreas according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-2	9.47	HRAS KRAS MUC1
2	Decreased viability	GR00106-A-0	9.47	KRAS
3	Decreased viability	GR00221-A-1	9.47	HRAS KRAS
4	Decreased viability	GR00221-A-2	9.47	HRAS KRAS
5	Decreased viability	GR00221-A-3	9.47	HRAS
6	Decreased viability	GR00301-A	9.47	KRAS
7	Decreased viability	GR00381-A-1	9.47	KRAS
8	Decreased viability	GR00402-S-2	9.47	HRAS KRAS MUC1

MGI Mouse Phenotypes related to Colloid Carcinoma of the Pancreas:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	10.03	BRCA2 HRAS KRAS KRT19 MUC5AC PHEX
2	immune system	MP:0005387	10.02	BRCA2 GGT1 KRAS MUC5AC MUC5B PHEX
3	endocrine/exocrine gland	MP:0005379	10.01	BRCA2 GGT1 HRAS KRAS KRT19 PHEX
4	integument	MP:0010771	9.87	BRCA2 GGT1 HRAS KRAS KRT19 SFN
5	limbs/digits/tail	MP:0005371	9.73	BRCA2 GGT1 KRAS PHEX SFN SMAD4
6	neoplasm	MP:0002006	9.7	BRCA2 HRAS KRAS KRT19 PSCA SFN
7	normal	MP:0002873	9.5	BRCA2 HRAS KRAS KRT19 MSLN PSCA
8	skeleton	MP:0005390	9.23	BRCA2 GGT1 HRAS KRAS KRT19 PHEX

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Drugs & Therapeutics for Colloid Carcinoma of the Pancreas

Search Clinical Trials , NIH Clinical Center for Colloid Carcinoma of the Pancreas

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Genetic Tests for Colloid Carcinoma of the Pancreas

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Anatomical Context for Colloid Carcinoma of the Pancreas

MalaCards organs/tissues related to Colloid Carcinoma of the Pancreas:

⁴²

Pancreas, Lung, Liver, Breast, Ovary, Appendix

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Publications for Colloid Carcinoma of the Pancreas

Articles related to Colloid Carcinoma of the Pancreas:

#	Title	Authors	Year
1	Pseudomyxoma peritonei associated with colloid carcinoma of the pancreas. ( 2998918 )	Chejfec G...Gould VE	1986

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Genes for Colloid Carcinoma of the Pancreas

Genes related to Colloid Carcinoma of the Pancreas (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PSCA	Prostate Stem Cell Antigen	Protein Coding	14.7	DISEASES inferred ¹⁵
2	MUC5B	Mucin 5B, Oligomeric Mucus/Gel-Forming	Protein Coding	14.5	DISEASES inferred ¹⁵
3	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	14.3	DISEASES inferred ¹⁵
4	PHEX	Phosphate Regulating Endopeptidase Homolog X-Linked	Protein Coding	14.01	DISEASES inferred ¹⁵
5	SMAD4	SMAD Family Member 4	Protein Coding	13.71	DISEASES inferred ¹⁵
6	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	13.66	DISEASES inferred ¹⁵
7	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	13.52	DISEASES inferred ¹⁵
8	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	13.1	DISEASES inferred ¹⁵
9	SFN	Stratifin	Protein Coding	4.64	DISEASES inferred ¹⁵
10	MSLN	Mesothelin	Protein Coding	4.35	DISEASES inferred ¹⁵
11	MUC5AC	Mucin 5AC, Oligomeric Mucus/Gel-Forming	Protein Coding	3.89	DISEASES inferred ¹⁵
12	GGTLC3	Gamma-Glutamyltransferase Light Chain Family Member 3	Protein Coding	3.74	DISEASES inferred ¹⁵
13	GGT2	Gamma-Glutamyltransferase 2	Protein Coding	3.73	DISEASES inferred ¹⁵
14	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	3.71	DISEASES inferred ¹⁵
15	KRT19	Keratin 19	Protein Coding	3.56	DISEASES inferred ¹⁵

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Variations for Colloid Carcinoma of the Pancreas

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Expression for Colloid Carcinoma of the Pancreas

Search GEO for disease gene expression data for Colloid Carcinoma of the Pancreas.

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Pathways for Colloid Carcinoma of the Pancreas

Pathways related to Colloid Carcinoma of the Pancreas according to GeneCards Suite gene sharing:

(show all 17)

#	Super pathways	Score	Top Affiliating Genes
1	Development EGFR signaling pathway ²³ Show member pathways Development ERBB-family signaling ²³ EGF Pathway ⁶⁵ EGFR Signaling Pathway ⁶⁸ ErbB receptor signaling network ¹	12.11	HRAS KRAS MUC1 SMAD4
2	Integrated Breast Cancer Pathway ¹	11.93	BRCA2 KRAS SMAD4
3	Diseases of glycosylation ⁶⁷ Show member pathways Diseases associated with O-glycosylation of proteins ⁶⁷	11.86	MUC1 MUC5AC MUC5B
4	Signaling pathways regulating pluripotency of stem cells ³⁸	11.81	HRAS KRAS SMAD4
5	FoxO signaling pathway ³⁸ Show member pathways PLK2 and PLK4 events ¹ Polo-like kinase signaling events in the cell cycle ¹	11.79	HRAS KRAS SMAD4
6	Apelin signaling pathway ³⁸	11.77	HRAS KRAS SMAD4
7	DNA Damage Response (only ATM dependent) ¹	11.64	HRAS KRAS SMAD4
8	MAP Kinase Signaling ⁴	11.6	HRAS KRAS SFN
9	CLEC7A (Dectin-1) signaling ⁶⁷ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁷ C-type lectin receptors (CLRs) ⁶⁷	11.43	HRAS KRAS MUC1 MUC5AC MUC5B
10	AGE-RAGE signaling pathway in diabetic complications ³⁸	11.33	HRAS KRAS SMAD4
11	Eicosanoid Synthesis ¹	10.94	GGT1 GGT2
12	Aflatoxin activation and detoxification ⁶⁷	10.91	GGT1 GGT2
13	MNAR-PELP1 and Estrogen Receptor Interaction ⁶⁵	10.9	HRAS KRAS
14	CD209 (DC-SIGN) signaling ⁶⁷	10.85	HRAS KRAS
15	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling ¹	10.73	HRAS KRAS
16	Extracellular vesicle-mediated signaling in recipient cells ¹	10.61	HRAS KRAS SMAD4
17	p38MAPK events ⁶⁷	10.37	HRAS KRAS

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GO Terms for Colloid Carcinoma of the Pancreas

Cellular components related to Colloid Carcinoma of the Pancreas according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.85	GGT1 HRAS KRAS KRT19 MSLN MUC1
2	extracellular exosome	GO:0070062	9.28	GGT1 GGT2 GGTLC3 KRT19 MUC1 MUC5AC
3	Golgi lumen	GO:0005796	9.13	MUC1 MUC5AC MUC5B

Biological processes related to Colloid Carcinoma of the Pancreas according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	female gonad development	GO:0008585	9.54	BRCA2 SMAD4
2	regulation of long-term neuronal synaptic plasticity	GO:0048169	9.52	HRAS KRAS
3	glutamate metabolic process	GO:0006536	9.51	GGT1 GGT2
4	O-glycan processing	GO:0016266	9.5	MUC1 MUC5AC MUC5B
5	zymogen activation	GO:0031638	9.49	GGT1 GGT2
6	response to estradiol	GO:0032355	9.48	GGT1 GGT2
7	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	9.46	BRCA2 MUC1
8	cysteine biosynthetic process	GO:0019344	9.43	GGT1 GGT2
9	response to isolation stress	GO:0035900	9.4	HRAS KRAS
10	regulation of immune system process	GO:0002682	9.37	GGT1 GGT2
11	glutathione catabolic process	GO:0006751	9.33	GGT1 GGT2 GGTLC3
12	peptide modification	GO:0031179	9.26	GGT1 GGT2
13	leukotriene D4 biosynthetic process	GO:1901750	9.13	GGT1 GGT2 GGTLC3
14	stimulatory C-type lectin receptor signaling pathway	GO:0002223	9.02	HRAS KRAS MUC1 MUC5AC MUC5B

Molecular functions related to Colloid Carcinoma of the Pancreas according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptidyltransferase activity	GO:0000048	8.96	GGT1 GGT2
2	glutathione hydrolase activity	GO:0036374	8.8	GGT1 GGT2 GGTLC3

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