MCID: CLN015
MIFTS: 65

Colon Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Colon Adenocarcinoma

MalaCards integrated aliases for Colon Adenocarcinoma:

Name: Colon Adenocarcinoma 12 54 6 15 17
Adenocarcinoma of Colon 12 71
Adenocarcinoma of the Colon 12
Colonic Adenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:234
NCIt 49 C4349
UMLS 71 C0338106

Summaries for Colon Adenocarcinoma

Disease Ontology : 12 A colon carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Colon Adenocarcinoma, also known as adenocarcinoma of colon, is related to adenocarcinoma and colorectal adenocarcinoma. An important gene associated with Colon Adenocarcinoma is APC (APC Regulator Of WNT Signaling Pathway), and among its related pathways/superpathways are Parkinson disease and Toll-like Receptor Signaling Pathway. The drugs tannic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and lung, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development... more...

Related Diseases for Colon Adenocarcinoma

Diseases related to Colon Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 620)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 33.1 TP53 PTGS2 PIK3CA MSH6 MLH1 KRT20
2 colorectal adenocarcinoma 32.0 TYMS TP53 PTGS2 MSH6 MLH1 KRT20
3 adenoma 32.0 TP53 PTGS2 PIK3CA ODC1 MSH6 MLH1
4 ulcerative colitis 31.6 PIK3CA MSH6 MLH1 CTNNB1 ABCB1
5 familial adenomatous polyposis 31.6 TP53 PTGS2 ODC1 MSH6 MLH1 CTNNB1
6 colitis 31.6 PTGS2 PIK3CA MSH6 MLH1 CTNNB1 BRAF
7 intrahepatic cholangiocarcinoma 31.5 TP53 KRT20 CTNNB1 CDH1 APC
8 lynch syndrome 31.5 TP53 PIK3CA MSH6 MLH1 CTNNB1 CDH1
9 cholangiocarcinoma 31.5 TP53 PTGS2 PIK3CA KRT20 CTNNB1 CEACAM5
10 mucinous adenocarcinoma 31.4 TP53 MLH1 KRT20 CEACAM5
11 lung cancer susceptibility 3 31.4 TP53 PTGS2 PIK3CA KRT20 CTNNB1 CEACAM5
12 colorectal cancer 31.4 TYMS TP53 SNHG6 PTGS2 PIK3CA ODC1
13 gastrointestinal stromal tumor 31.4 TP53 PTGS2 CDH1 CASP3 BRAF APC
14 rectum adenocarcinoma 31.4 TP53 PIK3CA MSH6 MLH1 KRT20 CTNNB1
15 rectum cancer 31.3 TYMS MSH6 MLH1 KRT20 CEACAM5 APC
16 lymphoma 31.3 TP53 PIK3CA MSH6 CDH1 CASP3 BRAF
17 villous adenoma 31.3 TP53 MLH1 KRT20 CEACAM5 BRAF APC
18 gastrointestinal carcinoma 31.2 TYMS TP53 KRT20 CEACAM5
19 in situ carcinoma 31.2 TP53 PIK3CA CTNNB1 CDH1
20 breast cancer 31.2 TYMS TP53 RAD54L PTGS2 PIK3CA ODC1
21 glioblastoma multiforme 31.2 TP53 PTGS2 PIK3CA CTNNB1 CDH1 CASP3
22 renal cell carcinoma, nonpapillary 31.2 TP53 PIK3CA KRT20 CDH1 BRAF BAX
23 peutz-jeghers syndrome 31.2 TP53 CTNNB1 APC
24 appendix adenocarcinoma 31.2 KRT20 CEACAM5
25 leukemia, chronic lymphocytic 31.1 TP53 PIK3CA CTNNB1 CASP3 BRAF BAX
26 colorectal adenoma 31.1 TP53 PTGS2 ODC1 MLH1 CTNNB1 CDH1
27 breast adenocarcinoma 31.1 TP53 PIK3CA ODC1 BAX ABCB1
28 carcinosarcoma 31.1 TP53 PIK3CA CTNNB1 CEACAM5 CDH1
29 ovarian cancer 31.1 TYMS TP53 PTGS2 PIK3CA MSH6 MLH1
30 pancreatic adenocarcinoma 31.1 TP53 PTGS2 PIK3CA MLH1 CTNNB1 CDH1
31 pseudomyxoma peritonei 31.1 TP53 KRT20 CTNNB1 CEACAM5 CDH1
32 myeloma, multiple 31.1 TP53 CTNNB1 CDH1 CASP3 BRAF ABCB1
33 signet ring cell adenocarcinoma 31.0 TP53 MLH1 KRT20 CTNNB1 CEACAM5 CDH1
34 esophageal cancer 31.0 TYMS TP53 PTGS2 PIK3CA MLH1 CTNNB1
35 papillary adenocarcinoma 31.0 TP53 CEACAM5 CDH1
36 mesothelioma, malignant 31.0 TYMS KRT20 CTNNB1 CEACAM5 CDH1
37 ureteral obstruction 31.0 TP53 PTGS2 CTNNB1
38 endometrial cancer 31.0 TP53 PIK3CA MSH6 MLH1 KRT20 CTNNB1
39 pancreatic cancer 31.0 TYMS TP53 PTGS2 PIK3CA MLH1 KRT20
40 gastric adenocarcinoma 31.0 TYMS TP53 PTGS2 PIK3CA ODC1 MLH1
41 sarcoma 31.0 TP53 PTGS2 PIK3CA CTNNB1 CASP3 BRAF
42 mismatch repair cancer syndrome 30.9 MSH6 MLH1 CTNNB1 APC
43 hyperplastic polyposis syndrome 30.9 TP53 BRAF APC
44 keratosis 30.9 TP53 PIK3CA CTNNB1 CEACAM5
45 adrenocortical carcinoma, hereditary 30.9 TP53 PIK3CA CTNNB1 BRAF
46 li-fraumeni syndrome 30.9 TP53 MSH6 MLH1 CTNNB1 CDH1 BAX
47 cystitis 30.9 TP53 PTGS2 KRT20 CDH1
48 large intestine adenocarcinoma 30.9 TP53 PIK3CA CTNNB1
49 bladder urothelial carcinoma 30.9 TP53 PIK3CA MLH1 KRT20 CTNNB1 CDH1
50 lymphoma, non-hodgkin, familial 30.9 TP53 RAD54L PIK3CA CASP3 BRAF BAX

Graphical network of the top 20 diseases related to Colon Adenocarcinoma:



Diseases related to Colon Adenocarcinoma

Symptoms & Phenotypes for Colon Adenocarcinoma

GenomeRNAi Phenotypes related to Colon Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.44 MLH1 RAD54L
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.44 BAX BRAF MLH1 RAD54L TP53
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.44 BAX MLH1 MSH6 RAD54L TP53 TYMS

MGI Mouse Phenotypes related to Colon Adenocarcinoma:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.36 APC BAX BRAF CASP3 CDH1 CTNNB1
2 endocrine/exocrine gland MP:0005379 10.3 ABCB1 ACSL4 APC BAX BRAF CASP3
3 homeostasis/metabolism MP:0005376 10.3 ABCB1 ACSL4 APC BAX BRAF CASP3
4 growth/size/body region MP:0005378 10.29 ABCB1 ACSL4 APC BAX BRAF CASP3
5 cardiovascular system MP:0005385 10.26 ABCB1 ACSL4 APC BRAF CASP3 CDH1
6 hematopoietic system MP:0005397 10.26 ABCB1 ACSL4 APC BAX BRAF CASP3
7 immune system MP:0005387 10.25 ABCB1 APC BAX BRAF CASP3 CDH1
8 mortality/aging MP:0010768 10.24 ABCB1 ACSL4 APC BAX BRAF CASP3
9 digestive/alimentary MP:0005381 10.19 ABCB1 APC BRAF CASP3 CDH1 CTNNB1
10 hearing/vestibular/ear MP:0005377 10.1 ABCB1 ACSL4 APC BAX BRAF CASP3
11 integument MP:0010771 10.1 APC BRAF CASP3 CDH1 CTNNB1 MLH1
12 neoplasm MP:0002006 9.96 APC BAX BRAF CDH1 CTNNB1 MLH1
13 muscle MP:0005369 9.92 APC BAX BRAF CASP3 CTNNB1 PIK3CA
14 reproductive system MP:0005389 9.73 ABCB1 ACSL4 APC BAX BRAF CASP3
15 no phenotypic analysis MP:0003012 9.7 ABCB1 CASP3 CDH1 CTNNB1 PIK3CA PTGS2
16 vision/eye MP:0005391 9.32 APC BAX BRAF CASP3 CTNNB1 MLH1

Drugs & Therapeutics for Colon Adenocarcinoma

Drugs for Colon Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 204)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved Phase 4 1401-55-4
2
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
3 Insulin, Globin Zinc Phase 4
4 insulin Phase 4
5
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
6
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
7
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
8
Irinotecan Approved, Investigational Phase 2, Phase 3 97682-44-5, 100286-90-6 60838
9
Tegafur Approved, Investigational Phase 3 17902-23-7 5386
10
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
11
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
12
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 3 7487-88-9 24083
13
leucovorin Approved Phase 2, Phase 3 58-05-9 6006 143
14
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
15
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
16
Tinzaparin Approved Phase 3 9041-08-1, 9005-49-6 25244225
17
Dalteparin Approved Phase 3 9005-49-6
18
Sunitinib Approved, Investigational Phase 2, Phase 3 557795-19-4, 341031-54-7 5329102
19
Atezolizumab Approved, Investigational Phase 3 1380723-44-3
20
Oxaliplatin Approved, Investigational Phase 2, Phase 3 61825-94-3 43805 6857599 5310940 9887054
21
Panitumumab Approved, Investigational Phase 2, Phase 3 339177-26-3 50070211
22
Bevacizumab Approved, Investigational Phase 3 216974-75-3
23
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
24
Fluorouracil Approved Phase 3 51-21-8 3385
25
Cetuximab Approved Phase 3 205923-56-4 56842117 2333
26
Promethazine Approved, Investigational Phase 3 60-87-7 4927
27
Diphenhydramine Approved, Investigational Phase 3 58-73-1, 147-24-0 3100
28
Floxuridine Approved Phase 3 50-91-9 5790
29
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
30
Celecoxib Approved, Investigational Phase 3 169590-42-5 2662
31
Folic acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
32 Edrecolomab Experimental, Investigational Phase 3 156586-89-9
33
Vatalanib Investigational Phase 3 212141-54-3 151194
34
Eniluracil Investigational Phase 3 59989-18-3
35 Cyclosporins Phase 3
36 Antifungal Agents Phase 3
37 Dermatologic Agents Phase 3
38 Calcineurin Inhibitors Phase 3
39 Alkylating Agents Phase 3
40 topoisomerase I inhibitors Phase 2, Phase 3
41 Semaxinib Phase 3
42 Mitomycins Phase 3
43
Liposomal doxorubicin Phase 3 31703
44
Erlotinib Hydrochloride Phase 3 183319-69-9 176871
45 Anesthetics Phase 3
46 Anti-Arrhythmia Agents Phase 3
47 Tocolytic Agents Phase 3
48 Anticonvulsants Phase 3
49 calcium channel blockers Phase 3
50 Immunoglobulin G Phase 3

Interventional clinical trials:

(show top 50) (show all 273)
# Name Status NCT ID Phase Drugs
1 Insulin Therapy Reduce Post-Operative Inflammatory Response After Curative Colorectal Cancer Resection: Randomization Controlled Trial Not yet recruiting NCT02746432 Phase 4 Hyper insulinemic euglycemic clamp
2 A RANDOMISED TRIAL OF INTRAVENOUS VERSUS INTRAHEPATIC ARTERIAL 5-FU AND LEUCOVORIN FOR COLORECTAL LIVER METASTASES Unknown status NCT00002692 Phase 3 fluorouracil;isolated perfusion;leucovorin calcium
3 Multicentre Phase III Comparing To Therapeutic Sequence: Folfiri Following of Folfox6 (Group A) and Folfox6 Following Of (Group B) For Metastatic Colorectal Cancer Unknown status NCT00003260 Phase 3 FOLFIRI regimen;FOLFOX regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium;oxaliplatin
4 CHEMOTHERAPY CHOICES IN ADVANCED COLORECTAL CANCER: A RANDOMISED TRIAL COMPARING 2 DURATIONS AND 3 SYSTEMIC CHEMOTHERAPY REGIMENS IN THE PALLIATIVE TREATMENT OF ADVANCED COLORECTAL CANCER Unknown status NCT00002893 Phase 3 fluorouracil;leucovorin calcium;raltitrexed
5 A Multicenter, Open-Label, Randomized, Three-Arm Study Of 5-Fluorouracil (5-FU) Plus Leucovorin (LV) Or Oxaliplatin Or A Combination Of (5-Fu) LV + Oxaliplatin As Second-Line Treatment Of Metastatic Colorectal Carcinoma Unknown status NCT00008281 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin
6 Phase III Study of An Optimized LV-5FU-Oxaliplatin Regimen in Metastatic Colorectal Cancer. C99-1. Unknown status NCT00006468 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin
7 Pilot / Phase III Randomized Trial Comparing Standard Systemic Therapy to Cytoreduction + Hyperthermic Intraperitoneal Mitomycin C + Standard Systemic Therapy in Patients With Limited Peritoneal Dissemination of Colon Adenocarcinoma Unknown status NCT01167725 Phase 3 FOLFIRI regimen;FOLFOX regimen;capecitabine;fluorouracil;irinotecan hydrochloride;leucovorin calcium;mitomycin C;oxaliplatin
8 A Randomised Clinical Trial of Treatment for Fluorouracil-Resistant Advanced Colorectal Cancer Comparing Standard Single-Agent Irinotecan Versus Irinotecan Plus Panitumumab and Versus Irinotecan Plus Ciclosporin [Panitumumab, Irinotecan & Ciclosporin in COLOrectal Cancer Therapy (PICCOLO)] Unknown status NCT00389870 Phase 3 cyclosporine;irinotecan hydrochloride
9 A Phase III, Randomized, Open-Label Multicenter, International Study Comparing The Combination Of SU5416/Irinotecan/5-Fluorouracil/Leucovorin Versus Irinotecan/Fluorouracil/Leucovorin Alone As First-Line Therapy Of Patient With Previously Untreated Metastatic Colorectal Cancer Unknown status NCT00021281 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium;semaxanib
10 Drug Treatment for Bowel Cancer: Making the Best Choices When a Milder Treatment is Needed Unknown status NCT00070213 Phase 3 FOLFOX regimen;capecitabine;fluorouracil;leucovorin calcium;oxaliplatin
11 Phase II-III Study of an Optimized LV-5FU-Oxaliplatin Strategy in Metastatic Colorectal Cancer. Optimox2 Study. C02-2 Unknown status NCT00274872 Phase 2, Phase 3 fluorouracil;leucovorin calcium;oxaliplatin
12 Randomized Phase III Intergroup Trial in Resected Stage 2 (Dukes B) Colon Cancer: 6-Month Infusional 5FU-CPT11 (+/- Folinic Acid) Versus Observation - Determination of Biologic Predictive and Response Factors Unknown status NCT00091312 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
13 Phase III Randomized Study of Intensive Adjuvant Chemotherapy for Resected Colon Cancer at High Risk of Recurrence Unknown status NCT00005979 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
14 5-Fluorouracil-Leucovorin With or Without Carboplatin as Adjuvant Treatment for Primary Dukes B2-C Colon Cancer; Chronomodulated Versus Standard Administration. A Multicenter Randomized Phase III Trial of the GRECCR-Belgium (Study 03). Unknown status NCT00046995 Phase 3 carboplatin;fluorouracil;leucovorin calcium
15 A Phase III Randomized Trial Investigating the Duration of Adjuvant Therapy(3 Versus 6 Months) With the Modified FOLFOX 6 or XELOX Regimens for Patients With Stage III Colon Cancer Unknown status NCT00958737 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin;XELOX regimen;Capecitabine
16 A Three-Arm Randomised Controlled Trial Comparing Either Continuous Chemotherapy Plus Cetuximab or Intermittent Chemotherapy With Standard Continuous Palliative Combination Chemotherapy With Oxaliplatin and a Fluoropyrimidine in First Line Treatment of Metastatic Colorectal Cancer (COIN) Unknown status NCT00182715 Phase 3 capecitabine;fluorouracil;leucovorin calcium;oxaliplatin
17 A Prospective Randomised Open Label Trial of Oxaliplatin/Fluoropyrimidine Versus Oxaliplatin/Fluoropyrimidine Plus Cetuximab Pre and Post Operatively in Patients With Resectable Colorectal Liver Metastasis Requiring Chemotherapy Unknown status NCT00482222 Phase 3 capecitabine;fluorouracil;leucovorin calcium;oxaliplatin
18 CPT-11 in Combination With Weekly 24 Hour Infusion 5-FU Plus Folinic Acid Relative to Weekly 24 Hour Infusion 5-FU Plus Folinic Acid Alone in Patients With Advanced Colorectal Cancer Completed NCT00004885 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
19 Randomized Phase III Trial of Adjuvant Chemotherapy With UFT vs. Observation in Curatively Resected Stage II Colon Cancer Completed NCT00392899 Phase 3 UFT adjuvant chemotherapy
20 Interracial Study of CPT-11 (Irinotecan) Pharmacokinetics in 5-Fluorouracil Refractory Colorectal Cancer: A Population Pharmacokinetic/Pharmacodynamic Study of CPT-11 Completed NCT00006103 Phase 3 fluorouracil;irinotecan hydrochloride;leucovorin calcium
21 PHASE III STUDY OF HEPATIC ARTERY FLOXURIDINE (FUDR), LEUCOVORIN (LV), AND DEXAMETHASONE (DEX) VERSUS SYSTEMIC 5-FLUOROURACIL (5-FU) AND LEUCOVORIN (LV) AS TREATMENT FOR HEPATIC METASTASES FROM COLORECTAL CANCER Completed NCT00002716 Phase 3 dexamethasone;floxuridine;fluorouracil;leucovorin calcium
22 A Randomized Phase I/III Study Of Systematic Chemotherapy With Or Without Hepatic Chemoembolization For Liver-Dominant Metastatic Adenocarcinoma Of The Colon And Rectum Completed NCT00023868 Phase 3 FOLFIRI regimen;cisplatin;doxorubicin hydrochloride;fluorouracil;irinotecan hydrochloride;leucovorin calcium;mitomycin C
23 A Randomized Phase III Trial of Three Different Regimens of CPT-11 Plus 5-Fluorouracil and Leucovorin Compared to 5-Fluorouracil and Leucovorin in Patients With Advanced Adenocarcinoma of the Colon and Rectum Completed NCT00003594 Phase 3 irinotecan;fluorouracil;leucovorin calcium;oxaliplatin
24 Phase III Randomized Study of Adjuvant Immunotherapy With Monoclonal Antibody 17-1A Versus No Adjuvant Therapy Following Resection for State II (Modified Astler-Coller B2) Adenocarcinoma of the Colon Completed NCT00002968 Phase 3
25 Multicenter Phase III Open Label Randomized Trial Comparing CPT-11 In Combination With A 5-FU/FA Infusional Regimen To The Same 5-FU/FA Infusional Regimen Alone As Adjuvant Treatment Of Stage III Colon Cancer Completed NCT00026273 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
26 First Line Infusional 5-Fluorouracil, Folinic Acid and Oxaliplatin for Metastatic Colorectal Cancer or Loco-Regional Recurrency - Role of Chronomodulated Delivery Upon Survival - A Multicenter Randomized Phase III Trial Completed NCT00003287 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin
27 Phase III Study of an Optimized Chemotherapy Followed by Maintenance With Bevacizumab Strategy With or Without Erlotinib in Unresectable Metastatic Colorectal Cancer. DREAM OPTIMOX 3. C04-2 Completed NCT00265824 Phase 3 bevacizumab;bevacizumab, erlotinib
28 A Phase III Randomized, Placebo-Controlled, Double-Blind Study of Intravenous Calcium/Magnesium in Two Different Versions to Prevent Oxaliplatin-Induced Sensory Neurotoxicity Completed NCT01099449 Phase 3 calcium gluconate;magnesium sulfate;oxaliplatin
29 Fluorouracil, Oxaliplatin and Irinotecan: Use and Sequencing: A Randomized Trial to Assess the Role of Irinotecan and Oxaliplatin in Advanced Colorectal Cancer Completed NCT00008060 Phase 3 FOLFIRI regimen;FOLFOX regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium;oxaliplatin
30 Irinotecan Combined With Infusional 5-FU/Folinic Acid or Capecitabine and the Role of Celecoxib in Patients With Metastatic Colorectal Cancer Completed NCT00064181 Phase 3 FOLFIRI regimen;capecitabine;celecoxib;fluorouracil;irinotecan hydrochloride;leucovorin calcium
31 A Randomized, Prospective Study Comparing Three Regimens Of Eloxatin ™ Plus Fluoropyrimidine For Evaluation Of Safety And Tolerability In First Line Treatment Of Patients With Advanced Colorectal Cancer (Tree Study) Completed NCT00062426 Phase 3 capecitabine;fluorouracil;leucovorin calcium;oxaliplatin
32 A Phase III Trial of Irinotecan / 5-FU / Leucovorin or Oxaliplatin / 5-FU/ Leucovorin With Bevacizumab, or Cetuximab (C225), or With the Combination of Bevacizumab and Cetuximab for Patients With Untreated Metastatic Adenocarcinoma of the Colon or Rectum Completed NCT00265850 Phase 3 FOLFOX or;FOLFIRI
33 A Clinical Trial to Evaluate the Postoperative Portal Vein Infusion of 5-Fluorouracil and Heparin in Patients With Resectable Adenocarcinoma of the Colon Completed NCT00427310 Phase 3 fluorouracil;sodium heparin
34 A Randomized, Double-blind, Placebo-controlled, Phase Lll Study in Patients With Metastatic Adenocarcinoma of the Colon or Rectum Who Are Receiving First-line Chemotherapy With Oxaliplatin/5-fluorouracil/Leucovorin With PTK787/ZK 222584 or Placebo Completed NCT00056459 Phase 3 Vatalanib
35 A Randomized, Double-blind, Placebo-controlled, Phase III Study of Oxaliplatin/5-fluorouracil/Leucovorin With PTK787/ZK 222584 or Placebo in Patients With Previously Treated Metastatic Adenocarcinoma of the Colon or Rectum Completed NCT00056446 Phase 3 Vatalanib
36 Pan-European Trials in Adjuvant Colon Cancer (PETACC-2): Randomized Phase III Intergroup Trial of High-Dose Infusional 5-FU (+ or - Folinic Acid) Versus Standard Bolus 5-FU/Folinic Acid Completed NCT00004150 Phase 3 fluorouracil;leucovorin calcium
37 A Clinical Trial Comparing Oral Uracil/Ftorafur (UFT) Plus Leucovorin (LV) With 5-Fluorouracil (5-FU) Plus LV in the Treatment of Patients With Stages II And III Carcinoma of the Colon Completed NCT00378716 Phase 3 5-fluorouracil;leucovorin calcium;tegafur;uracil
38 Multicenter, Double-Blind, Placebo-Controlled Randomized Phase III Study of Adjuvant Therapy With Celecoxib in Combination With Chemotherapy in Patients With Curatively Resected Stage III Colon Cancer Completed NCT00085163 Phase 3 celecoxib;fluorouracil;leucovorin calcium
39 Phase III Trial Comparing a 28 Day Schedule of Daily Oral 5-FU Plus Eniluracil to Protracted Intravenous Infusion in Previously Untreated Patients With Advanced Colorectal Cancer Completed NCT00003873 Phase 3 fluorouracil;eniluracil
40 A PHASE III PROSPECTIVE RANDOMIZED TRIAL COMPARING LAPAROSCOPIC-ASSISTED COLECTOMY VERSUS OPEN COLECTOMY FOR COLON CANCER Completed NCT00002575 Phase 3
41 A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Pegfilgrastim Admininstered to Subjects With Newly Diagnosed, Locally-advanced or Metastatic Colorectal Cancer Treated With Bevacizumab & Either 5-fluorouracil, Oxaliplatin, Leucovorin (FOLFOX) or 5-fluorouracil, Irinotecan, Leucovorin (FOLFIRI) Completed NCT00911170 Phase 3 Pegfilgrastim;Placebo;Standard Chemotherapy
42 Randomized Phase III Study of UFT+Leucovorin vs. TS-1 as Adjuvant Treatment for Stage III Colon Cancer , and Investigate Predictive Factors Based on Gene Expression Completed NCT00660894 Phase 3 folinate calcium;tegafur-uracil;tegafur-gimeracil-oteracil potassium
43 A Randomized Phase III Equivalence Trial of Irinotecan (CPT-11) Versus Oxaliplatin (OXAL)/5-Fluorouracil (5-FU)/Leucovorin (CF) in Patients With Advanced Colorectal Carcinoma Previously Treated With 5-FU Completed NCT00005036 Phase 3 irinotecan hydrochloride;oxaliplatin;leucovorin calcium;fluorouracil
44 A Randomized, Open-Label, Multicenter Phase III Study of 5-FU/Leucovorin With or Without Concomitant SU5416 in Patients With Metastatic Colorectal Cancer Completed NCT00004252 Phase 3 fluorouracil;leucovorin calcium;semaxanib
45 Phase III Intergroup Trial of Irinotecan (CPT-11) (NSC# 616348) Plus Fluorouracil/Leucovorin (5-FU/LV) Versus Fluorouracil/Leucovorin Alone After Curative Resection for Patients With Stage III Colon Cancer Completed NCT00003835 Phase 3 leucovorin calcium;fluorouracil;irinotecan hydrochloride
46 Phase III Trial of Bevacizumab (NSC 704865), Oxaliplatin (NSC 266046), Fluorouracil and Leucovorin Versus Oxaliplatin, Fluorouracil and Leucovorin Versus Bevacizumab Alone in Previously Treated Patients With Advanced Colorectal Cancer Completed NCT00025337 Phase 3 oxaliplatin;leucovorin calcium;fluorouracil
47 A Phase III Randomized, Placebo-Controlled, Double-Blind Study of Intravenous Calcium/Magnesium to Prevent Oxaliplatin-Induced Sensory Neurotoxicity Completed NCT00316914 Phase 3 calcium gluconate;magnesium sulfate
48 Randomized Study of Classic vs Simplified Leucovorin Calcium and Fluorouracil With or Without Irinotecan in Patients Aged At Least 75 Years With Advanced Colorectal Cancer Completed NCT00303771 Phase 3 fluorouracil;irinotecan hydrochloride;leucovorin calcium
49 A Phase III Clinical Trial Comparing Infusional 5-Fluorouracil (5-FU), Leucovorin, and Oxaliplatin (mFOLFOX6) Every Two Weeks With Bevacizumab to the Same Regimen Without Bevacizumab for the Treatment of Patients With Resected Stages II and III Carcinoma of the Colon Completed NCT00096278 Phase 3 Fluorouracil;Leucovorin Calcium;Oxaliplatin
50 Essai De Phase III De Chimiotherapie Par FOLFOX 4 Ou Par Une Succession FOLFOX 7 - FOLFIRI Chez Des Patients Ayant Des Metastases Resecables D'Origine Colorectale - MIROX Completed NCT00268398 Phase 3 oxaliplatin, folinic acid, fluorouracil;oxaliplatin, irinotecan, folinic acid, fluorouracil

Search NIH Clinical Center for Colon Adenocarcinoma

Genetic Tests for Colon Adenocarcinoma

Anatomical Context for Colon Adenocarcinoma

MalaCards organs/tissues related to Colon Adenocarcinoma:

40
Colon, Liver, Lung, T Cells, Lymph Node, Testes, Endothelial

Publications for Colon Adenocarcinoma

Articles related to Colon Adenocarcinoma:

(show top 50) (show all 4486)
# Title Authors PMID Year
1
Mutations in the RAD54 recombination gene in primary cancers. 6
10362365 1999
2
Fish fatty acids alter markers of apoptosis in colorectal adenoma and adenocarcinoma cell lines but fish consumption has no impact on apoptosis-induction ex vivo. 54 61
20107900 2010
3
TAF4b and Jun/activating protein-1 collaborate to regulate the expression of integrin alpha6 and cancer cell migration properties. 61 54
20353996 2010
4
Selective suicide gene therapy of colon cancer exploiting the urokinase plasminogen activator receptor promoter. 61 54
20199127 2010
5
Extracellular ATP activates MAP kinase cascades through a P2Y purinergic receptor in the human intestinal Caco-2 cell line. 61 54
19836435 2009
6
BRAF(V600E) efficient transformation and induction of microsatellite instability versus KRAS(G12V) induction of senescence markers in human colon cancer cells. 54 61
19881948 2009
7
Differences in TRAIL-induced changes of Mcl-1 expression among distinct human colon epithelial cell lines. 61 54
19782681 2009
8
Cyclooxygenase 2 modulates killing of cytotoxic T lymphocytes by colon cancer cells. 54 61
19794924 2009
9
No functional and transductional significance of specific neuropilin 1 siRNA inhibition in colon carcinoma cell lines lacking VEGF receptor 2. 61 54
19360289 2009
10
Chemopreventive effects of polysaccharides extract from Asterina pectinifera on HT-29 human colon adenocarcinoma cells. 54 61
19470241 2009
11
Soy isoflavones modulate azoxymethane-induced rat colon carcinogenesis exposed pre- and postnatally and inhibit growth of DLD-1 human colon adenocarcinoma cells by increasing the expression of estrogen receptor-beta. 54 61
19141699 2009
12
Sodium butyrate sensitizes human colon adenocarcinoma COLO 205 cells to both intrinsic and TNF-alpha-dependent extrinsic apoptosis. 54 61
19130237 2009
13
Human caspase-3 inhibition by Z-tLeu-Asp-H: tLeu(P2) counterbalances Asp(P4) and Glu(P3) specific inhibitor truncation. 61 54
18854175 2008
14
Wild-type APC regulates caveolin-1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc. 54 61
18444242 2008
15
Resveratrol directly targets COX-2 to inhibit carcinogenesis. 61 54
18381589 2008
16
ST6Gal-I expression in ovarian cancer cells promotes an invasive phenotype by altering integrin glycosylation and function. 61 54
19014651 2008
17
Smad7 induces hepatic metastasis in colorectal cancer. 61 54
18781153 2008
18
Upregulation of annexin A1 expression by butyrate in human colon adenocarcinoma cells: role of p53, NF-Y, and p38 mitogen-activated protein kinase. 54 61
18541673 2008
19
Lavendamycin antitumor agents: structure-based design, synthesis, and NAD(P)H:quinone oxidoreductase 1 (NQO1) model validation with molecular docking and biological studies. 54 61
18457384 2008
20
Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors. 61 54
18332086 2008
21
Cysteine 62 of Bax is critical for its conformational activation and its proapoptotic activity in response to H2O2-induced apoptosis. 61 54
18344566 2008
22
The urokinase receptor and its structural homologue C4.4A in human cancer: expression, prognosis and pharmacological inhibition. 61 54
18855679 2008
23
Bap29varP, a variant of Bap29, influences the cell surface expression of the human P-glycoprotein. 61 54
18097552 2008
24
Cyclin-dependent kinase 2/cyclin E complex is involved in p120 catenin (p120ctn)-dependent cell growth control: a new role for p120ctn in cancer. 61 54
17942908 2007
25
Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin. 61 54
17609769 2007
26
Correlation of induction of ATP binding cassette transporter A5 (ABCA5) and ABCB1 mRNAs with differentiation state of human colon tumor. 61 54
17541169 2007
27
Site-specific bidirectional efflux of 2,4-dinitrophenyl-S-glutathione, a substrate of multidrug resistance-associated proteins, in rat intestine and Caco-2 cells. 54 61
17430634 2007
28
Gene expression imaging by enzymatic catalysis of a fluorescent probe via membrane-anchored beta-glucuronidase. 61 54
17235292 2007
29
Effects of the flavonoid biochanin A on gene expression in primary human hepatocytes and human intestinal cells. 54 61
17340576 2007
30
Bombesin induces cyclooxygenase-2 expression through the activation of the nuclear factor of activated T cells and enhances cell migration in Caco-2 colon carcinoma cells. 54 61
16909108 2007
31
NF-kappaB/PPAR gamma and/or AP-1/PPAR gamma 'on/off' switches and induction of CBP in colon adenocarcinomas: correlation with COX-2 expression. 54 61
16506021 2007
32
Lipid excipients Peceol and Gelucire 44/14 decrease P-glycoprotein mediated efflux of rhodamine 123 partially due to modifying P-glycoprotein protein expression within Caco-2 cells. 61 54
17727795 2007
33
Ribonucleotide reductase subunits M2 and p53R2 are potential biomarkers for metastasis of colon cancer. 61 54
17311703 2007
34
Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes. 61 54
17106246 2006
35
Metastasis-suppressing potential of ribonucleotide reductase small subunit p53R2 in human cancer cells. 54 61
17085643 2006
36
Cytoplasmic phospholipase A2 expression in human colon adenocarcinoma is correlated with cyclooxygenase-2 expression and contributes to prostaglandin E2 production. 54 61
16458424 2006
37
[Inhibition of cell proliferation and C-myc cancer protein expression in human colon adenocarcinoma cell line HT29 with VIP-131I-ASON]. 61 54
17121362 2006
38
Neurotensin receptors in adeno- and squamous cell carcinoma. 61 54
17094477 2006
39
Elevation of radiolabelled thymidine uptake in RIF-1 fibrosarcoma and HT29 colon adenocarcinoma cells after treatment with thymidylate synthase inhibitors. 61 54
16568206 2006
40
Pre-treatment of HT-29 cells with 5-LOX inhibitor (MK-886) induces changes in cell cycle and increases apoptosis after photodynamic therapy with hypericin. 54 61
16545574 2006
41
Toward stable N4-modified neurotensins for NTS1-receptor-targeted tumor imaging with 99mTc. 61 54
16854083 2006
42
Role of Smad proteins in the regulation of NF-kappaB by TGF-beta in colon cancer cells. 61 54
16288847 2006
43
Concomitant cell growth and differentiation are dependent on erbB1 and integrin activation in an autonomously surviving colon adenocarcinoma: involvement of autocrine amphiregulin secretion. 61 54
16886596 2006
44
In-vivo imaging of tumor associated urokinase-type plasminogen activator activity. 61 54
16822063 2006
45
An increase in the number of adhesion proteins with altered expression is associated with an increased risk of cancer death for colon carcinoma patients. 61 54
15937692 2006
46
9-Hydroxystearic acid interferes with EGF signalling in a human colon adenocarcinoma. 61 54
16487928 2006
47
Sphingosine kinase 1 is up-regulated in colon carcinogenesis. 61 54
16319132 2006
48
Molokhia (Corchorus olitorius L.) extract suppresses transformation of the aryl hydrocarbon receptor induced by dioxins. 54 61
16115717 2006
49
Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis. 54 61
15922743 2005
50
Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway. 54 61
15757891 2005

Variations for Colon Adenocarcinoma

ClinVar genetic disease variations for Colon Adenocarcinoma:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 MSH6 NM_000179.2(MSH6):c.1808dup (p.Glu604fs)duplication Pathogenic 560013 rs1553413200 2:48026927-48026928 2:47799788-47799789
2 APC NM_000038.6(APC):c.3922_3926AAAGA[1] (p.Glu1309fs)short repeat Pathogenic 816 rs121913224 5:112175212-112175216 5:112839515-112839519
3 RAD54L NM_003579.4(RAD54L):c.188C>A (p.Pro63His)SNV Pathogenic 6191 rs121908688 1:46715769-46715769 1:46250097-46250097
4 APC NM_000038.6(APC):c.7832C>T (p.Thr2611Ile)SNV Uncertain significance 133523 rs587778037 5:112179123-112179123 5:112843426-112843426
5 APC NM_000038.6(APC):c.1463T>C (p.Leu488Pro)SNV Uncertain significance 559962 rs368434773 5:112162859-112162859 5:112827162-112827162

Cosmic variations for Colon Adenocarcinoma:

9 (show top 50) (show all 33543)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM97280902 ZZZ3 large intestine,colon,carcinoma,NS c.1366C>T p.P456S 1:77631989-77631989 3
2 COSM88263736 ZRSR2 large intestine,colon,carcinoma,NS c.553G>T p.D185Y 23:15809314-15809314 3
3 COSM88261539 ZRSR2 large intestine,colon,carcinoma,NS c.917G>A p.R306Q 23:15820296-15820296 3
4 COSM95950816 ZNHIT6 large intestine,colon,carcinoma,NS c.1364T>A p.L455H 1:85657855-85657855 3
5 COSM86861594 ZNHIT1 large intestine,colon,carcinoma,NS c.400C>T p.R134W 7:101223799-101223799 3
6 COSM98771566 ZNF813 large intestine,colon,carcinoma,NS c.1639G>A p.G547R 19:53491871-53491871 3
7 COSM91871130 ZNF536 large intestine,colon,carcinoma,NS c.1158G>T p.W386C 19:30444720-30444720 3
8 COSM91870713 ZNF536 large intestine,colon,carcinoma,NS c.2533C>G p.L845V 19:30548152-30548152 3
9 COSM94777824 ZNF521 large intestine,colon,carcinoma,NS c.3524C>T p.T1175M 18:25224394-25224394 3
10 COSM94774956 ZNF521 large intestine,rectum,carcinoma,NS c.799G>C p.E267Q 18:25227119-25227119 3
11 COSM86916483 ZNF280D large intestine,colon,carcinoma,NS c.2020A>C p.R674= 15:56658461-56658461 3
12 COSM95251466 ZNF217 large intestine,colon,carcinoma,NS c.967G>A p.D323N 20:53581860-53581860 3
13 COSM105811781 ZNF155 large intestine,colon,carcinoma,NS c.1454A>G p.H485R 19:43997278-43997278 3
14 COSM89535029 ZMIZ2 large intestine,colon,carcinoma,NS c.1850G>A p.R617H 7:44763403-44763403 3
15 COSM127394330 ZFHX4 large intestine,rectum,carcinoma,NS c.8291C>T p.P2764L 8:76855212-76855212 3
16 COSM127388315 ZFHX4 large intestine,colon,carcinoma,NS c.681C>A p.F227L 8:76704769-76704769 3
17 COSM149275347 ZFHX3 large intestine,colon,carcinoma,NS c.7928G>A p.R2643H 16:72794754-72794754 3
18 COSM149294291 ZFHX3 large intestine,colon,carcinoma,NS c.392G>T p.G131V 16:72959754-72959754 3
19 COSM149316595 ZFHX3 large intestine,rectum,carcinoma,NS c.4628G>A p.R1543H 16:72798054-72798054 3
20 COSM149297634 ZFHX3 large intestine,colon,carcinoma,NS c.9227T>G p.M3076R 16:72793455-72793455 3
21 COSM149331878 ZFHX3 large intestine,colon,carcinoma,NS c.2548C>A p.L850I 16:72957598-72957598 3
22 COSM149281001 ZFHX3 large intestine,colon,carcinoma,NS c.7490C>T p.S2497L 16:72795192-72795192 3
23 COSM149281007 ZFHX3 large intestine,colon,carcinoma,NS c.2324C>T p.A775V 16:72957822-72957822 3
24 COSM149295261 ZFHX3 large intestine,rectum,carcinoma,NS c.7279G>A p.D2427N 16:72795403-72795403 3
25 COSM149287754 ZFHX3 large intestine,rectum,carcinoma,NS c.6692C>T p.P2231L 16:72795990-72795990 3
26 COSM149281665 ZFHX3 large intestine,colon,carcinoma,NS c.8968G>A p.V2990I 16:72793714-72793714 3
27 COSM149303003 ZFHX3 large intestine,colon,carcinoma,NS c.4251G>C p.Q1417H 16:72798431-72798431 3
28 COSM149332863 ZFHX3 large intestine,colon,carcinoma,NS c.10415C>T p.A3472V 16:72787861-72787861 3
29 COSM149262764 ZFHX3 large intestine,colon,carcinoma,NS c.1532C>A p.P511H 16:72958614-72958614 3
30 COSM149309557 ZFHX3 large intestine,colon,carcinoma,NS c.7804A>G p.T2602A 16:72794878-72794878 3
31 COSM149331841 ZFHX3 large intestine,colon,carcinoma,NS c.4242A>C p.E1414D 16:72798440-72798440 3
32 COSM149309565 ZFHX3 large intestine,colon,carcinoma,NS c.7666G>A p.A2556T 16:72795016-72795016 3
33 COSM149283939 ZFHX3 large intestine,colon,carcinoma,NS c.10346C>T p.A3449V 16:72787930-72787930 3
34 COSM149331838 ZFHX3 large intestine,colon,carcinoma,NS c.9997C>A p.Q3333K 16:72788279-72788279 3
35 COSM149288753 ZFHX3 large intestine,colon,carcinoma,NS c.2339C>T p.A780V 16:72957807-72957807 3
36 COSM149286811 ZFHX3 large intestine,rectum,carcinoma,NS c.2875G>A p.D959N 16:72950810-72950810 3
37 COSM149314781 ZFHX3 large intestine,colon,carcinoma,NS c.3863C>T p.T1288M 16:72811578-72811578 3
38 COSM149321671 ZFHX3 large intestine,colon,carcinoma,NS c.3412A>T p.I1138F 16:72889767-72889767 3
39 COSM149288742 ZFHX3 large intestine,rectum,carcinoma,NS c.10831C>A p.H3611N 16:72787445-72787445 3
40 COSM149307391 ZFHX3 large intestine,colon,carcinoma,NS c.1238C>A p.T413N 16:72958908-72958908 3
41 COSM149310951 ZFHX3 large intestine,colon,carcinoma,NS c.9467G>A p.S3156N 16:72788809-72788809 3
42 COSM149267318 ZFHX3 large intestine,colon,carcinoma,NS c.3367C>T p.R1123W 16:72889812-72889812 3
43 COSM149286804 ZFHX3 large intestine,rectum,carcinoma,NS c.8360C>A p.P2787H 16:72794322-72794322 3
44 COSM149292048 ZFHX3 large intestine,colon,carcinoma,NS c.10754C>G p.S3585C 16:72787522-72787522 3
45 COSM149316603 ZFHX3 large intestine,rectum,carcinoma,NS c.4309A>G p.S1437G 16:72798373-72798373 3
46 COSM149276729 ZFHX3 large intestine,colon,carcinoma,NS c.3829G>A p.V1277M 16:72811612-72811612 3
47 COSM149309571 ZFHX3 large intestine,colon,carcinoma,NS c.7381G>A p.E2461K 16:72795301-72795301 3
48 COSM149289422 ZFHX3 large intestine,colon,carcinoma,NS c.5555A>C p.Q1852P 16:72797127-72797127 3
49 COSM149316587 ZFHX3 large intestine,rectum,carcinoma,NS c.8875A>G p.K2959E 16:72793807-72793807 3
50 COSM149267991 ZFHX3 large intestine,colon,carcinoma,NS c.6296C>T p.P2099L 16:72796386-72796386 3

Expression for Colon Adenocarcinoma

Search GEO for disease gene expression data for Colon Adenocarcinoma.

Pathways for Colon Adenocarcinoma

Pathways related to Colon Adenocarcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.09 TP53 PTGS2 PIK3CA CTNNB1 CASP3 BRAF
2
Show member pathways
13.05 TP53 PIK3CA CTNNB1 CASP3 BRAF BAX
3
Show member pathways
12.95 TP53 PTGS2 PIK3CA CTNNB1 CASP3 BAX
4
Show member pathways
12.94 TP53 PTGS2 PIK3CA CTNNB1 CASP3 BAX
5
Show member pathways
12.73 TP53 CTNNB1 CDH1 CASP3 BAX APC
6
Show member pathways
12.72 TP53 PIK3CA MLH1 CTNNB1 CDH1 BRAF
7
Show member pathways
12.7 TP53 PIK3CA MSH6 MLH1 CTNNB1 CDH1
8 12.62 TP53 PTGS2 PIK3CA MSH6 MLH1 CTNNB1
9
Show member pathways
12.61 TP53 PIK3CA MSH6 CDH1 BRAF BAX
10
Show member pathways
12.61 TP53 PTGS2 PIK3CA CTNNB1 CDH1 CASP3
11 12.51 TYMS TP53 RAD54L MSH6 MLH1
12
Show member pathways
12.5 TP53 PIK3CA CTNNB1 CDH1 CASP3
13 12.48 TP53 PTGS2 PIK3CA CASP3 APC ABCB1
14
Show member pathways
12.43 TP53 PIK3CA CTNNB1 CASP3 BAX
15 12.42 TP53 PTGS2 CTNNB1 CDH1 APC
16
Show member pathways
12.39 PTGS2 PIK3CA CTNNB1 BRAF
17
Show member pathways
12.39 PIK3CA CTNNB1 CDH1 BRAF APC
18
Show member pathways
12.32 PIK3CA CTNNB1 CDH1 BRAF
19 12.29 TP53 PIK3CA CASP3 BAX
20
Show member pathways
12.28 TP53 PIK3CA CTNNB1 BAX APC
21 12.26 TP53 PIK3CA CTNNB1 CASP3 BRAF
22
Show member pathways
12.24 TP53 PIK3CA CASP3 BRAF BAX
23
Show member pathways
12.15 TP53 CASP3 BRAF BAX
24 12.1 CTNNB1 CDH1 CASP3 APC
25 12.06 TP53 MLH1 BAX APC
26 11.96 TP53 CTNNB1 BRAF APC
27 11.92 TP53 PIK3CA CTNNB1 BAX APC
28 11.83 TYMS TP53 MSH6
29
Show member pathways
11.8 PIK3CA CASP3 BRAF BAX
30 11.8 TP53 RAD54L ODC1 MSH6 CTNNB1 CDH1
31 11.79 TP53 ODC1 BAX
32 11.79 TP53 PTGS2 PIK3CA CASP3 BAX
33 11.77 CTNNB1 CDH1 APC
34 11.77 TP53 BRAF BAX
35 11.73 TP53 CDH1 BRAF
36 11.73 PIK3CA CTNNB1 CDH1
37 11.71 TP53 PIK3CA MSH6 MLH1 CASP3 BAX
38
Show member pathways
11.68 TP53 PIK3CA CASP3
39 11.62 PTGS2 CTNNB1 CASP3
40 11.56 TP53 PTGS2 CASP3
41 11.54 TP53 PTGS2 MSH6 MLH1 CTNNB1 CDH1
42 11.53 TP53 PIK3CA CASP3 APC
43
Show member pathways
11.44 TP53 MLH1 ABCB1
44 11.44 TP53 MSH6 CASP3 BAX
45 11.39 TP53 PTGS2 BAX
46 11.32 PIK3CA CTNNB1 CDH1
47 11.18 TP53 CASP3 BAX
48 11.17 PIK3CA CTNNB1 CDH1
49 11.12 CASP3 BAX ABCB1
50 10.83 CTNNB1 CDH1

GO Terms for Colon Adenocarcinoma

Cellular components related to Colon Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 beta-catenin destruction complex GO:0030877 9.4 CTNNB1 APC
2 Wnt signalosome GO:1990909 9.37 CTNNB1 APC
3 lateral plasma membrane GO:0016328 9.33 CTNNB1 CDH1 APC
4 mismatch repair complex GO:0032300 9.32 MSH6 MLH1
5 flotillin complex GO:0016600 9.26 CTNNB1 CDH1
6 lamellipodium GO:0030027 9.26 PIK3CA CTNNB1 CDH1 APC
7 catenin complex GO:0016342 8.8 CTNNB1 CDH1 APC

Biological processes related to Colon Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.97 TP53 PTGS2 CTNNB1 BAX APC
2 regulation of cell proliferation GO:0042127 9.88 TP53 PTGS2 CTNNB1 BRAF
3 negative regulation of apoptotic process GO:0043066 9.88 TP53 PTGS2 CTNNB1 CEACAM5 CASP3 BRAF
4 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.77 PTGS2 PIK3CA BRAF
5 response to glucocorticoid GO:0051384 9.74 TYMS PTGS2 CASP3
6 positive regulation of apoptotic process GO:0043065 9.73 TP53 PTGS2 CTNNB1 CASP3 BAX APC
7 cellular response to UV GO:0034644 9.7 TP53 PTGS2 BAX
8 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.69 MSH6 MLH1 BAX
9 response to UV GO:0009411 9.67 TP53 MSH6 CASP3
10 neuron apoptotic process GO:0051402 9.61 TP53 CASP3 BAX
11 response to salt stress GO:0009651 9.59 TP53 BAX
12 entry of bacterium into host cell GO:0035635 9.56 CTNNB1 CDH1
13 DNA strand renaturation GO:0000733 9.55 TP53 RAD54L
14 regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 9.54 TP53 BAX
15 intrinsic apoptotic signaling pathway GO:0097193 9.54 TP53 MSH6 BAX
16 determination of adult lifespan GO:0008340 9.5 TP53 RAD54L MSH6
17 cellular response to DNA damage stimulus GO:0006974 9.5 TP53 RAD54L MSH6 MLH1 CASP3 BAX
18 cellular response to indole-3-methanol GO:0071681 9.48 CTNNB1 CDH1
19 somatic recombination of immunoglobulin gene segments GO:0016447 9.46 MSH6 MLH1
20 positive regulation of neuron apoptotic process GO:0043525 9.46 TP53 CTNNB1 CASP3 BAX
21 response to drug GO:0042493 9.23 TYMS TP53 RAD54L PTGS2 CTNNB1 CDH1

Molecular functions related to Colon Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.86 TYMS RAD54L PIK3CA MSH6 MLH1 BRAF
2 ATP binding GO:0005524 9.56 TP53 RAD54L PIK3CA MSH6 MLH1 BRAF
3 enzyme binding GO:0019899 9.55 TP53 PTGS2 MSH6 MLH1 CTNNB1
4 beta-catenin binding GO:0008013 9.54 CTNNB1 CDH1 APC
5 gamma-catenin binding GO:0045295 9.4 CDH1 APC
6 mismatched DNA binding GO:0030983 9.32 MSH6 MLH1
7 guanine/thymine mispair binding GO:0032137 8.62 MSH6 MLH1

Sources for Colon Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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