MCID: CLN015
MIFTS: 57

Colon Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Colon Adenocarcinoma

MalaCards integrated aliases for Colon Adenocarcinoma:

Name: Colon Adenocarcinoma 12 13 56 15 17
Adenocarcinoma of the Colon 12 6
Adenocarcinoma of Colon 12 74
Colonic Adenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:234
NCIt 51 C4349
UMLS 74 C0338106

Summaries for Colon Adenocarcinoma

Disease Ontology : 12 A colon carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Colon Adenocarcinoma, also known as adenocarcinoma of the colon, is related to adenocarcinoma and adenoma. An important gene associated with Colon Adenocarcinoma is APC (APC Regulator Of WNT Signaling Pathway), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Benzocaine and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and lung, and related phenotypes are cellular and endocrine/exocrine gland

Wikipedia : 77 Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from... more...

Related Diseases for Colon Adenocarcinoma

Diseases related to Colon Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 279)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 32.4 APC CDH1 CTNNB1 MLH1 PTGS2
2 adenoma 30.8 APC CTNNB1 MLH1 ODC1 PTGS2
3 colitis 30.6 ABCB1 CTNNB1 MLH1 PTGS2
4 cholangiocarcinoma 30.4 CDH1 CEACAM5 CTNNB1 KRT20 PTGS2
5 lung cancer susceptibility 3 30.2 APC CASP3 CDH1 CEACAM5 CTNNB1 KRT20
6 transitional cell carcinoma 30.2 CDH1 KRT20 PTGS2
7 mismatch repair cancer syndrome 29.7 APC CTNNB1 MLH1 MSH6
8 lynch syndrome 29.6 APC CTNNB1 MLH1 MSH6
9 hepatocellular carcinoma 29.5 ABCB1 APC BAX CASP3 CDH1 CEACAM5
10 familial adenomatous polyposis 29.3 APC CDH1 CTNNB1 MLH1 MSH6 ODC1
11 ovarian cancer 29.3 ABCB1 BAX CASP3 CDH1 CTNNB1 MLH1
12 colorectal adenocarcinoma 29.2 CDH1 CEACAM5 CTNNB1 KRT20 MLH1 MSH6
13 breast cancer 28.9 ABCB1 APC BAX CASP3 CDH1 CEACAM5
14 colorectal cancer 28.2 ABCB1 APC BAX CAHM CASP3 CDH1
15 keratosis palmoplantaris adenocarcinoma of the colon 12.3
16 submucosal invasive colon adenocarcinoma 12.2
17 colon mucinous adenocarcinoma 11.6
18 desmoid disease, hereditary 10.6 APC CTNNB1
19 polyposis syndrome, hereditary mixed, 1 10.5 APC MLH1 PTGS2
20 familial adenomatous polyposis 1 10.5 APC CTNNB1
21 large intestine adenocarcinoma 10.5 CDH1 CTNNB1 KRT20
22 goblet cell carcinoid 10.5 CDH1 CTNNB1 KRT20
23 barrett esophagus 10.5 APC KRT20 ODC1 PTGS2
24 esophageal adenosquamous carcinoma 10.5 CDH1 CEACAM5
25 familial colorectal cancer 10.5 APC CDH1 MLH1
26 lower lip cancer 10.5 CASP3 MLH1
27 linitis plastica 10.5 CDH1 KRT20
28 lung acinar adenocarcinoma 10.5 CTNNB1 KRT20
29 nasopharyngeal disease 10.5 CASP3 CDH1 CTNNB1
30 oral cancer 10.5 CASP3 CDH1 PTGS2
31 colonic benign neoplasm 10.5 CEACAM5 CTNNB1 PTGS2
32 infiltrative basal cell carcinoma 10.5 CDH1 CEACAM5 KRT20
33 pharynx cancer 10.5 CASP3 CDH1 CTNNB1
34 cervix disease 10.5 CASP3 CDH1 CTNNB1
35 hepatoblastoma 10.5 ABCB1 APC CASP3 CTNNB1
36 gastrointestinal system benign neoplasm 10.5 CEACAM5 CTNNB1 PTGS2
37 anaplastic thyroid cancer 10.5 CASP3 CDH1 CTNNB1
38 male reproductive organ cancer 10.5 CASP3 CDH1 CTNNB1
39 euryblepharon 10.4 CDH1 CTNND1
40 tongue cancer 10.4 CASP3 CDH1 CTNNB1
41 intrahepatic cholangiocarcinoma 10.4 CDH1 CTNNB1 KRT20
42 uterine carcinosarcoma 10.4 CDH1 CTNNB1 PTGS2
43 lymphoma, non-hodgkin, familial 10.4 ABCB1 BAX CASP3 RAD54L
44 breast ductal carcinoma 10.4 CDH1 CTNNB1 RAD54L
45 cell type benign neoplasm 10.4 CEACAM5 CTNNB1 MLH1
46 hematologic cancer 10.4 ABCB1 BAX CASP3 MLH1
47 colorectal adenoma 10.4 APC CTNNB1 MLH1 ODC1 PTGS2
48 tongue squamous cell carcinoma 10.4 CASP3 CDH1 CTNNB1
49 fibroepithelial basal cell carcinoma 10.4 CEACAM5 KRT20
50 adenoid squamous cell carcinoma 10.4 CDH1 KRT20

Graphical network of the top 20 diseases related to Colon Adenocarcinoma:



Diseases related to Colon Adenocarcinoma

Symptoms & Phenotypes for Colon Adenocarcinoma

MGI Mouse Phenotypes related to Colon Adenocarcinoma:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.27 APC BAX CASP3 CDH1 CTNNB1 CTNND1
2 endocrine/exocrine gland MP:0005379 10.16 ABCB1 ACSL4 APC BAX CASP3 CDH1
3 homeostasis/metabolism MP:0005376 10.15 ABCB1 ACSL4 APC BAX CASP3 CDH1
4 hematopoietic system MP:0005397 10.1 ABCB1 ACSL4 APC BAX CASP3 CTNNB1
5 digestive/alimentary MP:0005381 10.08 ABCB1 APC CASP3 CDH1 CTNNB1 CTNND1
6 immune system MP:0005387 10.02 ABCB1 APC BAX CASP3 CDH1 CTNNB1
7 mortality/aging MP:0010768 9.97 ABCB1 ACSL4 APC BAX CASP3 CDH1
8 hearing/vestibular/ear MP:0005377 9.91 ABCB1 ACSL4 APC BAX CASP3 CTNNB1
9 integument MP:0010771 9.91 APC CASP3 CDH1 CTNNB1 CTNND1 MLH1
10 neoplasm MP:0002006 9.61 APC BAX CDH1 CTNNB1 CTNND1 MLH1
11 reproductive system MP:0005389 9.28 ABCB1 ACSL4 APC BAX CASP3 CDH1

Drugs & Therapeutics for Colon Adenocarcinoma

Drugs for Colon Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 223)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
2
tannic acid Approved Phase 4 1401-55-4
3
Zinc Approved, Investigational Phase 4 7440-66-6 32051
4 insulin Phase 4
5 Insulin, Globin Zinc Phase 4
6 Hypoglycemic Agents Phase 4
7
Capecitabine Approved, Investigational Phase 3,Phase 2,Phase 1 154361-50-9 60953
8
leucovorin Approved Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
9
Irinotecan Approved, Investigational Phase 3,Phase 2,Phase 1 100286-90-6, 97682-44-5 60838
10
Levoleucovorin Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 68538-85-2
11
Oxaliplatin Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 61825-94-3 6857599 5310940 9887054 43805
12
Fluorouracil Approved Phase 3,Phase 2,Phase 1,Not Applicable 51-21-8 3385
13
Bevacizumab Approved, Investigational Phase 3,Phase 2,Phase 1 216974-75-3
14
Cetuximab Approved Phase 3,Phase 2,Phase 1,Early Phase 1 205923-56-4 56842117 2333
15
Carboplatin Approved Phase 3 41575-94-4 38904 10339178 498142
16
Panitumumab Approved, Investigational Phase 3,Phase 2,Phase 1 339177-26-3 50070211
17
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
18
Raltitrexed Approved, Investigational Phase 3,Phase 2,Phase 1 112887-68-0 104758
19
Celecoxib Approved, Investigational Phase 3,Phase 2 169590-42-5 2662
20
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
21
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
22
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 441203 84093 2767
23
Tegafur Approved, Investigational Phase 3,Phase 2,Phase 1 17902-23-7 5386
24
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 3 7487-88-9 24083
25
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 1177-87-3
26
Floxuridine Approved Phase 3,Phase 2,Phase 1 50-91-9 5790
27
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
28
Dalteparin Approved Phase 3 9005-49-6
29
Tinzaparin Approved Phase 3 9041-08-1, 9005-49-6 25244225
30
Atezolizumab Approved, Investigational Phase 3 1380723-44-3
31
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
32
Histamine Approved, Investigational Phase 3 51-45-6 774
33
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
34
Promethazine Approved, Investigational Phase 3 60-87-7 4927
35
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
36
Calcium Approved, Nutraceutical Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7440-70-2 271
37 Edrecolomab Experimental, Investigational Phase 3 156586-89-9
38
Doxil Approved June 1999 Phase 3,Phase 2 31703
39
Vatalanib Investigational Phase 3 212141-54-3 151194
40
Eniluracil Investigational Phase 3 59989-18-3
41 Folate Phase 3,Phase 2,Phase 1
42 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
43 Antineoplastic Agents, Immunological Phase 3,Phase 2,Phase 1,Early Phase 1
44 Hormones Phase 3,Phase 2,Phase 1,Early Phase 1
45 Antidotes Phase 3,Phase 2,Phase 1
46 Micronutrients Phase 3,Phase 2,Phase 1,Early Phase 1
47 Angiogenesis Inhibitors Phase 3,Phase 2,Phase 1
48 Antimetabolites Phase 3,Phase 2,Phase 1
49 Immunologic Factors Phase 3,Phase 2,Phase 1,Early Phase 1
50 Protective Agents Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 269)
# Name Status NCT ID Phase Drugs
1 Insulin Therapy Reduce Post-Operative Inflammatory Response After Curative Colorectal Cancer Resection: Randomization Controlled Trial Not yet recruiting NCT02746432 Phase 4 Hyper insulinemic euglycemic clamp
2 Standard Therapy With or Without Surgery and Mitomycin C in Treating Patients With Advanced Limited Peritoneal Dissemination of Colon Cancer Unknown status NCT01167725 Phase 3 FOLFIRI regimen;FOLFOX regimen;capecitabine;fluorouracil;irinotecan hydrochloride;leucovorin calcium;mitomycin C;oxaliplatin
3 Cetuximab and/or Bevacizumab Combined With Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00265850 Phase 3 FOLFOX or;FOLFIRI
4 Combination Chemotherapy for 3 Months or 6 Months in Treating Patients With Stage III Colon Cancer Unknown status NCT00958737 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin;XELOX regimen;Capecitabine
5 Fluorouracil and Irinotecan With or Without Leucovorin Compared With Observation in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer Unknown status NCT00091312 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
6 Combination Chemotherapy With or Without Irinotecan in Treating Patients With Stage III Colon Cancer Unknown status NCT00005979 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
7 Combination Chemotherapy With or Without Cetuximab as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00182715 Phase 3 capecitabine;fluorouracil;leucovorin calcium;oxaliplatin
8 Combination Chemotherapy in Treating Patients With Colon Cancer Unknown status NCT00046995 Phase 3 carboplatin;fluorouracil;leucovorin calcium
9 Leucovorin and Fluorouracil With or Without Oxaliplatin Compared to Capecitabine With or Without Oxaliplatin in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00070213 Phase 3 FOLFOX regimen;capecitabine;fluorouracil;leucovorin calcium;oxaliplatin
10 Irinotecan With or Without Panitumumab or Cyclosporine in Treating Patients With Advanced or Metastatic Colorectal Cancer That Did Not Respond to Fluorouracil Unknown status NCT00389870 Phase 3 cyclosporine;irinotecan hydrochloride
11 Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery Unknown status NCT00274872 Phase 2, Phase 3 fluorouracil;leucovorin calcium;oxaliplatin
12 Combination Chemotherapy in Treating Patients With Recurrent Metastatic Colorectal Cancer Unknown status NCT00003260 Phase 3 FOLFIRI regimen;FOLFOX regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium;oxaliplatin
13 Combination Chemotherapy With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00021281 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium;semaxanib
14 Comparison of Three Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00008281 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin
15 Comparing Two Combination Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00006468 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin
16 Combination Chemotherapy With or Without Cetuximab Before and After Surgery in Treating Patients With Resectable Liver Metastases Caused By Colorectal Cancer Unknown status NCT00482222 Phase 3 capecitabine;fluorouracil;leucovorin calcium;oxaliplatin
17 Intravenous Compared With Intrahepatic Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the Liver Unknown status NCT00002692 Phase 3 fluorouracil;isolated perfusion;leucovorin calcium
18 Palliative Chemotherapy in Treating Patients With Advanced Colorectal Cancer Unknown status NCT00002893 Phase 3 fluorouracil;leucovorin calcium;raltitrexed
19 Edrecolomab in Treating Patients With Stage II Colon Cancer Completed NCT00002968 Phase 3
20 Liver Infusions of Fluorouracil in Treating Patients With Dukes' A, Dukes' B, or Dukes' C Colon Cancer Undergoing Surgery Completed NCT00427310 Phase 3 fluorouracil;sodium heparin
21 Combination Chemotherapy With or Without Chemoembolization in Treating Patients With Colorectal Cancer Metastatic to the Liver Completed NCT00023868 Phase 3 FOLFIRI regimen;cisplatin;doxorubicin hydrochloride;fluorouracil;irinotecan hydrochloride;leucovorin calcium;mitomycin C
22 Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer Completed NCT00003594 Phase 3 irinotecan;fluorouracil;leucovorin calcium;oxaliplatin
23 Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Previously Treated Metastatic Colorectal Cancer Completed NCT00056446 Phase 3 Vatalanib
24 Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Metastatic Colorectal Cancer. Completed NCT00056459 Phase 3 Vatalanib
25 Combination Chemotherapy in Treating Patients With Stage III Colon Cancer Completed NCT00003835 Phase 3 leucovorin calcium;fluorouracil;irinotecan hydrochloride
26 Comparison of Combination Chemotherapy Regimens With or Without Cetuximab in Treating Patients Who Have Undergone Surgery For Stage III Colon Cancer Completed NCT00079274 Phase 3 irinotecan hydrochloride;oxaliplatin;leucovorin calcium;fluorouracil;Locally Directed Therapy
27 Tegafur-Uracil and Leucovorin or S-1 in Treating Patients With Stage III Colon Cancer That Has Been Completely Removed by Surgery Completed NCT00660894 Phase 3 folinate calcium;tegafur-uracil;tegafur-gimeracil-oteracil potassium
28 Celecoxib Combined With Fluorouracil and Leucovorin in Treating Patients With Resected Stage III Adenocarcinoma (Cancer) of the Colon Completed NCT00085163 Phase 3 celecoxib;fluorouracil;leucovorin calcium
29 Combination Chemotherapy With or Without Cetuximab in Treating Patients With Stage III Colon Cancer That Was Completely Removed By Surgery Completed NCT00265811 Phase 3 Folfox + Cetuximab;Folfox
30 High-Dose Fluorouracil With or Without Leucovorin Compared With Standard Fluorouracil Plus Leucovorin Following Surgery in Treating Patients With Stage III Colon Cancer Completed NCT00004150 Phase 3 fluorouracil;leucovorin calcium
31 Combination Chemotherapy in Treating Patients With Resected Colon Cancer Completed NCT00378716 Phase 3 5-fluorouracil;leucovorin calcium;tegafur;uracil
32 Combination Chemotherapy With or Without Celecoxib in Treating Patients With Metastatic Colorectal Cancer Completed NCT00064181 Phase 3 FOLFIRI regimen;capecitabine;celecoxib;fluorouracil;irinotecan hydrochloride;leucovorin calcium
33 Tegafur-Uracil or Observation in Treating Patients With Stage II Colorectal Cancer That Has Been Completely Removed By Surgery Completed NCT00392899 Phase 3 UFT adjuvant chemotherapy
34 Fluorouracil and Leucovorin With or Without Irinotecan in Treating Patients Following Surgery for Stage III Colorectal Cancer Completed NCT00026273 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
35 Laparoscopic-Assisted Surgery Compared With Open Surgery in Treating Patients With Colon Cancer Completed NCT00002575 Phase 3
36 Irinotecan Compared With Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer Completed NCT00005036 Phase 3 irinotecan hydrochloride;oxaliplatin;leucovorin calcium;fluorouracil
37 Fluorouracil With or Without Eniluracil in Treating Patients With Advanced Colorectal Cancer Completed NCT00003873 Phase 3 fluorouracil;eniluracil
38 Combination Chemotherapy in Treating Patients With Colorectal Cancer and Resectable Metastases Completed NCT00268398 Phase 3 oxaliplatin, folinic acid, fluorouracil;oxaliplatin, irinotecan, folinic acid, fluorouracil
39 Optimized Chemotherapy Followed by Maintenance With Bevacizumab With or Without Erlotinib in Treating Patients With Metastatic Colorectal Cancer That Cannot be Removed by Surgery (DREAM) Completed NCT00265824 Phase 3 bevacizumab;bevacizumab, erlotinib
40 Leucovorin and Fluorouracil With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer Completed NCT00004252 Phase 3 fluorouracil;leucovorin calcium;semaxanib
41 Fluorouracil, Leucovorin, and Oxaliplatin With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II or Stage III Colon Cancer Completed NCT00096278 Phase 3 oxaliplatin;leucovorin calcium;fluorouracil
42 Combination Chemotherapy With or Without Bevacizumab Compared With Bevacizumab Alone in Treating Patients With Advanced or Metastatic Colorectal Cancer That Has Been Previously Treated Completed NCT00025337 Phase 3 oxaliplatin;leucovorin calcium;fluorouracil
43 Oxaliplatin and Bevacizumab (Avastin™) With Either Fluorouracil and Leucovorin or Capecitabine in Treating Patients With Advanced Colorectal Cancer Completed NCT00062426 Phase 3 capecitabine;fluorouracil;leucovorin calcium;oxaliplatin
44 Combination Chemotherapy as First-Line Therapy in Treating Older Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery Completed NCT00303771 Phase 3 fluorouracil;irinotecan hydrochloride;leucovorin calcium
45 PAVES: Pegfilgrastim Anti-vascular Endothelial Growth Factor (VEGF) Evaluation Study Completed NCT00911170 Phase 3 Pegfilgrastim;Placebo;Standard Chemotherapy
46 Fluorouracil and Leucovorin With or Without Irinotecan in Treating Patients With Metastatic Colorectal Cancer Completed NCT00004885 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
47 Combination Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer Completed NCT00003287 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin
48 Combination Chemotherapy in Treating Patients With Unresectable Metastatic Colorectal Cancer Completed NCT00008060 Phase 3 FOLFIRI regimen;FOLFOX regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium;oxaliplatin
49 Study of Tumor Tissue Testing in Selecting Treatment for Patients With Metastatic or Locally Advanced Colorectal Cancer Completed NCT00975897 Phase 2, Phase 3 fluorouracil;irinotecan hydrochloride;leucovorin calcium;oxaliplatin
50 Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity Caused By Oxaliplatin in Patients Receiving Combination Chemotherapy for Stage II, Stage III, or Stage IV Colorectal Cancer That Has Been Completely Removed By Surgery Completed NCT00316914 Phase 3 calcium gluconate;magnesium sulfate

Search NIH Clinical Center for Colon Adenocarcinoma

Genetic Tests for Colon Adenocarcinoma

Anatomical Context for Colon Adenocarcinoma

MalaCards organs/tissues related to Colon Adenocarcinoma:

42
Colon, Liver, Lung, Testes, Lymph Node, Endothelial, Breast

Publications for Colon Adenocarcinoma

Articles related to Colon Adenocarcinoma:

(show top 50) (show all 1256)
# Title Authors Year
1
Large single cutaneous metastasis of colon adenocarcinoma mimicking a squamous cell carcinoma of the skin: A case report. ( 30870738 )
2019
2
The First Evidence of Cryptosporidium meleagridis Infection in a Colon Adenocarcinoma From an Immunocompetent Patient. ( 30886833 )
2019
3
Anti-proliferative activity and cell metabolism of hydroxycinnamic acids in human colon adenocarcinoma cell lines. ( 30892877 )
2019
4
TRAIL Expressing Recombinant Lactococcus lactis Induces Apoptosis in Human Colon Adenocarcinoma SW480 and HCT116 Cells. ( 30815963 )
2019
5
ZNF692 promotes colon adenocarcinoma cell growth and metastasis by activating the PI3K/AKT pathway. ( 30816443 )
2019
6
Cathepsin B Is Upregulated and Mediates ECM Degradation in Colon Adenocarcinoma HT29 Cells Overexpressing Snail. ( 30818851 )
2019
7
Colon Adenocarcinoma Stage IIA-Can We Predict Relapse? ( 30834501 )
2019
8
Colon adenocarcinoma with metastases to the scaphoid: a case report and review of the literature. ( 30788095 )
2019
9
Metachronous metastasis to inguinal lymph nodes from sigmoid colon adenocarcinoma with abdominal wall metastasis: a case report. ( 30813921 )
2019
10
Treatment of cancer stem cells from human colon adenocarcinoma cell line HT-29 with resveratrol and sulindac induced mesenchymal-endothelial transition rate. ( 30758710 )
2019
11
A Competing Endogenous RNA Network Reveals Novel Potential lncRNA, miRNA, and mRNA Biomarkers in the Prognosis of Human Colon Adenocarcinoma. ( 30691798 )
2019
12
Lymphovascular Invasion and Perineural Invasion Negatively Impact Overall Survival for Stage II Adenocarcinoma of the Colon. ( 30640833 )
2019
13
Simultaneous occurrence of IgG4-related Tubulointerstitial nephritis and colon adenocarcinoma with hepatic metastasis: a case report and literature review. ( 30651091 )
2019
14
Inspecting human colon adenocarcinoma cell lines by using terahertz time-domain reflection spectroscopy. ( 30593945 )
2019
15
Permeability of the ellagitannin geraniin and its metabolites in a human colon adenocarcinoma Caco-2 cell culture model. ( 30566155 )
2019
16
Chronic spontaneous urticaria associated with colon adenocarcinoma: A paraneoplastic manifestation? A case report and review of literature. ( 30581946 )
2019
17
miR-223-RhoB signaling pathway regulates the proliferation and apoptosis of colon adenocarcinoma. ( 29660302 )
2018
18
Hsa-miR-370 inhibited P-selectin-induced cell adhesion in human colon adenocarcinoma cells. ( 29922946 )
2018
19
Minimally invasive surgery for stage III colon adenocarcinoma is associated with less delay to initiation of adjuvant systemic therapy and improved survival. ( 29967992 )
2018
20
Transforming Growth Factor Beta 2 Inhibits Growth and Proliferation Potential of Smad4 and p53 Mutated Human Colon Adenocarcinoma Cells. ( 29948613 )
2018
21
A rare case of ascending colon adenocarcinoma incarcerated in an inguinoscrotal hernia: case report and literature review. ( 29785528 )
2018
22
Vaccination with human amniotic epithelial cells confer effective protection in a murine model of Colon adenocarcinoma. ( 29139122 )
2018
23
Expression of Hippo pathway genes and their clinical significance in colon adenocarcinoma. ( 29541248 )
2018
24
<i>De novo</i> expression of human polypeptide<i>N</i>-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium. ( 29187600 )
2018
25
Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation. ( 29289836 )
2018
26
Curcumin induces apoptosis and cell cycle arrest via the activation of reactive oxygen species-independent mitochondrial apoptotic pathway in Smad4 and p53 mutated colon adenocarcinoma HT29 cells. ( 29673545 )
2018
27
A rare case of oral metastasis of colon adenocarcinoma. ( 29475082 )
2018
28
G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma. ( 29971639 )
2018
29
Comprehensive analysis of differential expression profiles of mRNAs and lncRNAs and identification of a 14-lncRNA prognostic signature for patients with colon adenocarcinoma. ( 29565464 )
2018
30
Colon adenocarcinoma presenting a Plummer-Vinson Syndrome. ( 29885869 )
2018
31
Co-expression Network Analysis Identified COL8A1 Is Associated with the Progression and Prognosis in Human Colon Adenocarcinoma. ( 29497907 )
2018
32
Phalangeal metastasis in colon adenocarcinoma. ( 29807858 )
2018
33
A 65a89gene signature for prognostic prediction in colon adenocarcinoma. ( 29393333 )
2018
34
A rare case of <i>Clostridium septicum</i> aortitis with colon adenocarcinoma. ( 29707691 )
2018
35
Frequency of Somatic TP53 Mutations in Combination with Known Pathogenic Mutations in Colon Adenocarcinoma, Non-Small Cell Lung Carcinoma, and Gliomas as Identified by Next-Generation Sequencing. ( 29454261 )
2018
36
Gastrointestinal Neuroendocrine Tumor, Colon Adenocarcinoma, and Hyperparathyroidism: An Unorthodox Synchronism. ( 30800541 )
2018
37
ki-67 and Topoisomerase IIa proliferation markers in colon adenocarcinoma. ( 30722108 )
2018
38
Distinct prognostic value of dynactin subunit 4 (DCTN4) and diagnostic value of DCTN1, DCTN2, and DCTN4 in colon adenocarcinoma. ( 30510450 )
2018
39
Identification of prognostic miRNA biomarkers for predicting overall survival of colon adenocarcinoma and bioinformatics analysis: A study based on The Cancer Genome Atlas database. ( 30536901 )
2018
40
Two subsequent metachronous diseases: Granuloma annulare and colon adenocarcinoma. ( 30539883 )
2018
41
Identification of key lncRNAs in the carcinogenesis and progression of colon adenocarcinoma by co-expression network analysis. ( 30430631 )
2018
42
Prognostic differences between lymphoepithelioma-like colon carcinoma and colon adenocarcinoma. ( 30449118 )
2018
43
Significance of PYK2 level as a prognosis predictor in patients with colon adenocarcinoma after surgical resection. ( 30464511 )
2018
44
Optimization of nimesulide-loaded Solid Lipid Nanoparticles (SLN) by factorial design, release profile and cytotoxicity in human colon adenocarcinoma cell line. ( 30477410 )
2018
45
Pyruvate Treatment Restores the Effectiveness of Chemotherapeutic Agents in Human Colon Adenocarcinoma and Pleural Mesothelioma Cells. ( 30423827 )
2018
46
E2F1-mediated MNX1-AS1-miR-218-5p-SEC61A1 feedback loop contributes to the progression of colon adenocarcinoma. ( 30362161 )
2018
47
Cutaneous metastasis of colon adenocarcinoma. ( 30302429 )
2018
48
Identification of long noncoding RNAs biomarkers for diagnosis and prognosis in patients with colon adenocarcinoma. ( 30269368 )
2018
49
MicroRNA-145 regulates the proliferation, migration and invasion of human primary colon adenocarcinoma cells by targeting MAPK1. ( 30272312 )
2018
50
Pharmacokinetic, Antiproliferative and Apoptotic Effects of Phenolic Acids in Human Colon Adenocarcinoma Cells Using In Vitro and In Silico Approaches. ( 30297681 )
2018

Variations for Colon Adenocarcinoma

ClinVar genetic disease variations for Colon Adenocarcinoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 APC NM_000038.5(APC): c.3927_3931delAAAGA (p.Glu1309Aspfs) deletion Pathogenic rs121913224 GRCh37 Chromosome 5, 112175218: 112175222
2 APC NM_000038.5(APC): c.3927_3931delAAAGA (p.Glu1309Aspfs) deletion Pathogenic rs121913224 GRCh38 Chromosome 5, 112839521: 112839525
3 RAD54L NM_001142548.1(RAD54L): c.188C> A (p.Pro63His) single nucleotide variant Pathogenic rs121908688 GRCh37 Chromosome 1, 46715769: 46715769
4 RAD54L NM_001142548.1(RAD54L): c.188C> A (p.Pro63His) single nucleotide variant Pathogenic rs121908688 GRCh38 Chromosome 1, 46250097: 46250097
5 APC NM_000038.5(APC): c.7832C> T (p.Thr2611Ile) single nucleotide variant Uncertain significance rs587778037 GRCh37 Chromosome 5, 112179123: 112179123
6 APC NM_000038.5(APC): c.7832C> T (p.Thr2611Ile) single nucleotide variant Uncertain significance rs587778037 GRCh38 Chromosome 5, 112843426: 112843426
7 APC NM_001127511.2(APC): c.1409T> C (p.Leu470Pro) single nucleotide variant Uncertain significance rs368434773 GRCh37 Chromosome 5, 112162859: 112162859
8 APC NM_001127511.2(APC): c.1409T> C (p.Leu470Pro) single nucleotide variant Uncertain significance rs368434773 GRCh38 Chromosome 5, 112827162: 112827162
9 MSH6 NM_000179.2(MSH6): c.1805_1806insA (p.Glu604Glyfs) insertion Pathogenic rs1553413200 GRCh37 Chromosome 2, 48026928: 48026928
10 MSH6 NM_000179.2(MSH6): c.1805_1806insA (p.Glu604Glyfs) insertion Pathogenic rs1553413200 GRCh38 Chromosome 2, 47799788: 47799789

Cosmic variations for Colon Adenocarcinoma:

9 (show top 50) (show all 11359)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM33066 ZZZ3 large intestine,colon,carcinoma,NS c.1366C>T p.P456S 1:77631989-77631989 0
2 COSM6940205 ZRSR2 large intestine,colon,carcinoma,NS c.553G>T p.D185Y 23:15809314-15809314 0
3 COSM6452015 ZRSR2 large intestine,colon,carcinoma,NS c.917G>A p.R306Q 23:15820296-15820296 0
4 COSM33067 ZNHIT6 large intestine,colon,carcinoma,NS c.1364T>A p.L455H 1:85657855-85657855 0
5 COSM32824 ZNHIT1 large intestine,colon,carcinoma,NS c.400C>T p.R134W 7:101223799-101223799 0
6 COSM50818 ZNF813 large intestine,colon,carcinoma,NS c.1636G>A p.G546R 19:53491871-53491871 0
7 COSM50466 ZNF536 large intestine,colon,carcinoma,NS c.2533C>G p.L845V 19:30548152-30548152 0
8 COSM50465 ZNF536 large intestine,colon,carcinoma,NS c.1158G>T p.W386C 19:30444720-30444720 0
9 COSM50282 ZNF521 large intestine,rectum,carcinoma,NS c.799G>C p.E267Q 18:25227119-25227119 0
10 COSM50281 ZNF521 large intestine,colon,carcinoma,NS c.3524C>T p.T1175M 18:25224394-25224394 0
11 COSM50969 ZNF280D large intestine,colon,carcinoma,NS c.2020A>C p.R674R 15:56658461-56658461 0
12 COSM32994 ZNF217 large intestine,colon,carcinoma,NS c.967G>A p.D323N 20:53581860-53581860 0
13 COSM32679 ZNF155 large intestine,colon,carcinoma,NS c.1421A>G p.H474R 19:43997278-43997278 0
14 COSM50671 ZMIZ2 large intestine,colon,carcinoma,NS c.1850G>A p.R617H 7:44763403-44763403 0
15 COSM50764 ZFHX4 large intestine,colon,carcinoma,NS c.681C>A p.F227L 8:76704769-76704769 0
16 COSM50768 ZFHX4 large intestine,rectum,carcinoma,NS c.8291C>T p.P2764L 8:76855212-76855212 0
17 COSM6964399 ZFHX3 large intestine,colon,carcinoma,NS c.2339C>T p.A780V 16:72957807-72957807 0
18 COSM6974762 ZFHX3 large intestine,colon,carcinoma,NS c.9467G>A p.S3156N 16:72788809-72788809 0
19 COSM6944275 ZFHX3 large intestine,colon,carcinoma,NS c.2324C>T p.A775V 16:72957822-72957822 0
20 COSM6946346 ZFHX3 large intestine,rectum,carcinoma,NS c.8875A>G p.K2959E 16:72793807-72793807 0
21 COSM6957094 ZFHX3 large intestine,colon,carcinoma,NS c.3412A>T p.I1138F 16:72889767-72889767 0
22 COSM3512090 ZFHX3 large intestine,rectum,carcinoma,NS c.1670C>T p.S557F 16:72958476-72958476 0
23 COSM6953704 ZFHX3 large intestine,colon,carcinoma,NS c.1623G>C p.Q541H 16:72958523-72958523 0
24 COSM6845173 ZFHX3 large intestine,colon,carcinoma,NS c.3863C>T p.T1288M 16:72811578-72811578 0
25 COSM973505 ZFHX3 large intestine,colon,carcinoma,NS c.7928G>A p.R2643H 16:72794754-72794754 0
26 COSM6964664 ZFHX3 large intestine,colon,carcinoma,NS c.2318C>T p.A773V 16:72957828-72957828 0
27 COSM6939325 ZFHX3 large intestine,colon,carcinoma,NS c.9997C>A p.Q3333K 16:72788279-72788279 0
28 COSM6941382 ZFHX3 large intestine,colon,carcinoma,NS c.392G>T p.G131V 16:72959754-72959754 0
29 COSM6973708 ZFHX3 large intestine,rectum,carcinoma,NS c.8360C>A p.P2787H 16:72794322-72794322 0
30 COSM6954498 ZFHX3 large intestine,rectum,carcinoma,NS c.10831C>A p.H3611N 16:72787445-72787445 0
31 COSM6964606 ZFHX3 large intestine,colon,carcinoma,NS c.5555A>C p.Q1852P 16:72797127-72797127 0
32 COSM6960915 ZFHX3 large intestine,rectum,carcinoma,NS c.6692C>T p.P2231L 16:72795990-72795990 0
33 COSM6939326 ZFHX3 large intestine,colon,carcinoma,NS c.4242A>C p.E1414D 16:72798440-72798440 0
34 COSM6964400 ZFHX3 large intestine,colon,carcinoma,NS c.500C>T p.P167L 16:72959646-72959646 0
35 COSM6941989 ZFHX3 large intestine,colon,carcinoma,NS c.4251G>C p.Q1417H 16:72798431-72798431 0
36 COSM6941490 ZFHX3 large intestine,colon,carcinoma,NS c.10415C>T p.A3472V 16:72787861-72787861 0
37 COSM6955210 ZFHX3 large intestine,colon,carcinoma,NS c.7381G>A p.E2461K 16:72795301-72795301 0
38 COSM6955208 ZFHX3 large intestine,colon,carcinoma,NS c.7804A>G p.T2602A 16:72794878-72794878 0
39 COSM4062694 ZFHX3 large intestine,colon,carcinoma,NS c.10346C>T p.A3449V 16:72787930-72787930 0
40 COSM6946348 ZFHX3 large intestine,rectum,carcinoma,NS c.4309A>G p.S1437G 16:72798373-72798373 0
41 COSM6942790 ZFHX3 large intestine,colon,carcinoma,NS c.1532C>A p.P511H 16:72958614-72958614 0
42 COSM6977044 ZFHX3 large intestine,colon,carcinoma,NS c.3367C>T p.R1123W 16:72889812-72889812 0
43 COSM6956224 ZFHX3 large intestine,colon,carcinoma,NS c.950T>A p.L317H 16:72959196-72959196 0
44 COSM6941990 ZFHX3 large intestine,colon,carcinoma,NS c.1081G>A p.G361R 16:72959065-72959065 0
45 COSM6845156 ZFHX3 large intestine,rectum,carcinoma,NS c.2875G>A p.D959N 16:72950810-72950810 0
46 COSM6978946 ZFHX3 large intestine,colon,carcinoma,NS c.9227T>G p.M3076R 16:72793455-72793455 0
47 COSM6927022 ZFHX3 large intestine,colon,carcinoma,NS c.2822C>T p.S941L 16:72950863-72950863 0
48 COSM6959968 ZFHX3 large intestine,colon,carcinoma,NS c.2548C>A p.L850I 16:72957598-72957598 0
49 COSM6950051 ZFHX3 large intestine,colon,carcinoma,NS c.1238C>A p.T413N 16:72958908-72958908 0
50 COSM6946347 ZFHX3 large intestine,rectum,carcinoma,NS c.4628G>A p.R1543H 16:72798054-72798054 0

Expression for Colon Adenocarcinoma

Search GEO for disease gene expression data for Colon Adenocarcinoma.

Pathways for Colon Adenocarcinoma

Pathways related to Colon Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.61 APC BAX CASP3 CDH1 CTNNB1 MLH1
2 12.53 APC BAX CASP3 CDH1 CTNNB1 MLH1
3
Show member pathways
12.51 APC BAX CASP3 CDH1 CTNNB1 PTGS2
4
Show member pathways
12.47 ABCB1 APC BAX CDH1 CTNNB1 MLH1
5 12.41 ABCB1 APC CASP3 PTGS2
6 12.33 APC CDH1 CTNNB1 PTGS2
7 11.98 APC CASP3 CDH1 CTNNB1
8 11.89 CDH1 CEACAM5 CTNNB1 CTNND1
9
Show member pathways
11.84 APC CASP3 CDH1 CTNNB1
10 11.77 BAX CASP3 PTGS2
11
Show member pathways
11.76 CDH1 CTNNB1 CTNND1
12 11.69 BAX CASP3 CDH1 CTNNB1 MSH6 ODC1
13 11.68 APC CDH1 CTNNB1
14 11.62 CDH1 CTNNB1 CTNND1
15 11.53 BAX CASP3 MLH1 MSH6
16 11.52 CASP3 CTNNB1 PTGS2
17 11.44 APC BAX CASP3 CDH1 CTNNB1 MLH1
18 11.41 BAX CASP3 MSH6
19 11.39 CDH1 CTNNB1 CTNND1
20 11.34 CDH1 CTNNB1 CTNND1
21
Show member pathways
11.33 ABCB1 MLH1 NQO1
22 11.31 CDH1 CTNNB1 CTNND1
23 11.2 CDH1 CTNNB1 CTNND1
24 11.1 MLH1 MSH6 NQO1
25 10.97 ABCB1 BAX CASP3
26 10.81 ABCB1 PTGS2
27 10.73 CDH1 CTNNB1
28 10.6 ABCB1 BAX

GO Terms for Colon Adenocarcinoma

Cellular components related to Colon Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 postsynaptic density, intracellular component GO:0099092 9.48 CTNNB1 CTNND1
2 presynaptic active zone cytoplasmic component GO:0098831 9.46 CTNNB1 CTNND1
3 lamellipodium GO:0030027 9.46 APC CDH1 CTNNB1 CTNND1
4 mismatch repair complex GO:0032300 9.43 MLH1 MSH6
5 lateral plasma membrane GO:0016328 9.43 APC CDH1 CTNNB1
6 beta-catenin destruction complex GO:0030877 9.4 APC CTNNB1
7 Wnt signalosome GO:1990909 9.37 APC CTNNB1
8 flotillin complex GO:0016600 9.32 CDH1 CTNNB1
9 cell-cell adherens junction GO:0005913 9.26 APC CDH1 CTNNB1 CTNND1
10 catenin complex GO:0016342 8.92 APC CDH1 CTNNB1 CTNND1

Biological processes related to Colon Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.95 CASP3 CEACAM5 CTNNB1 NQO1 PTGS2
2 positive regulation of apoptotic process GO:0043065 9.83 APC BAX CASP3 CTNNB1 PTGS2
3 cellular response to DNA damage stimulus GO:0006974 9.8 APC BAX CASP3 MLH1 MSH6 RAD54L
4 response to toxic substance GO:0009636 9.7 BAX CDH1 NQO1
5 response to organic substance GO:0010033 9.69 CASP3 CDH1 PTGS2
6 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.65 BAX MLH1 MSH6
7 response to drug GO:0042493 9.63 ABCB1 CASP3 CDH1 CTNNB1 PTGS2 RAD54L
8 adherens junction organization GO:0034332 9.58 CDH1 CTNNB1 CTNND1
9 somatic hypermutation of immunoglobulin genes GO:0016446 9.57 MLH1 MSH6
10 isotype switching GO:0045190 9.56 MLH1 MSH6
11 response to estradiol GO:0032355 9.56 CASP3 CTNNB1 NQO1 PTGS2
12 determination of adult lifespan GO:0008340 9.54 MSH6 RAD54L
13 regulation of cellular amino acid metabolic process GO:0006521 9.49 NQO1 ODC1
14 cellular response to indole-3-methanol GO:0071681 9.46 CDH1 CTNNB1
15 somatic recombination of immunoglobulin gene segments GO:0016447 9.37 MLH1 MSH6
16 positive regulation of neuron apoptotic process GO:0043525 9.26 BAX CASP3 CTNNB1 NQO1
17 entry of bacterium into host cell GO:0035635 8.8 CDH1 CTNNB1 CTNND1

Molecular functions related to Colon Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cadherin binding GO:0045296 9.62 APC CDH1 CTNNB1 CTNND1
2 protein homodimerization activity GO:0042803 9.43 BAX CDH1 CEACAM5 MSH6 ODC1 PTGS2
3 gamma-catenin binding GO:0045295 9.26 APC CDH1
4 mismatched DNA binding GO:0030983 9.16 MLH1 MSH6
5 guanine/thymine mispair binding GO:0032137 8.62 MLH1 MSH6

Sources for Colon Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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