MCID: CLN044
MIFTS: 42

Colon Adenoma

Categories: Cancer diseases, Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Colon Adenoma

MalaCards integrated aliases for Colon Adenoma:

Name: Colon Adenoma 12 15
Adenomatous Polyp of Colon 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050912
UMLS 71 C0850572

Summaries for Colon Adenoma

Disease Ontology : 12 A colonic benign neoplasm that has material basis in epithelial tissue with glandular origin.

MalaCards based summary : Colon Adenoma, also known as adenomatous polyp of colon, is related to adenoma and colorectal adenoma. An important gene associated with Colon Adenoma is APC (APC Regulator Of WNT Signaling Pathway), and among its related pathways/superpathways are Signaling by GPCR and HIV Life Cycle. The drugs nivolumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and pancreas, and related phenotypes are cellular and growth/size/body region

Related Diseases for Colon Adenoma

Diseases related to Colon Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 194)
# Related Disease Score Top Affiliating Genes
1 adenoma 32.1 SMAD4 SMAD3 KRAS APC
2 colorectal adenoma 31.4 VEGFA VDR KRAS APC
3 familial adenomatous polyposis 31.2 SMAD4 OGG1 KRAS APC
4 adenocarcinoma 30.8 VEGFA SMAD4 SMAD3 MMP2 KRAS EGF
5 colorectal cancer 30.8 VEGFA VDR SMAD4 SMAD3 OGG1 MMP2
6 lynch syndrome 30.6 SMAD4 OGG1 KRAS APC
7 colon adenocarcinoma 30.1 VEGFA SMAD4 MMP2 KRAS EGF CASP3
8 inflammatory bowel disease 29.9 VEGFA VDR SMAD3 MMP2 KRAS EGF
9 colorectal adenocarcinoma 29.8 VEGFA MMP2 KRAS EGF CASP3 APC
10 leukemia, acute myeloid 29.5 VEGFA SPN MIR182 KRAS FBXW7 EGF
11 polyposis syndrome, hereditary mixed, 1 11.6
12 familial adenomatous polyposis 4 11.4
13 polyposis syndrome, hereditary mixed, 2 11.3
14 familial adenomatous polyposis 3 11.3
15 attenuated familial adenomatous polyposis 10.6 OGG1 APC
16 hyperplastic polyposis syndrome 10.6 KRAS APC
17 ampulla of vater neoplasm 10.6 KRAS APC
18 periampullary adenoma 10.6 KRAS APC
19 myh-associated polyposis 10.5 KRAS APC
20 oropharynx cancer 10.5 VEGFA EGF APC
21 colonic benign neoplasm 10.5 LGR5 KRAS APC
22 pancreatic ductal carcinoma 10.5 VEGFA SMAD4 EGF
23 vitreous disease 10.4 VEGFA MMP2 EGF
24 endometrial adenocarcinoma 10.4 VEGFA KRAS EGF
25 gastrointestinal system benign neoplasm 10.4 LGR5 KRAS APC
26 arteriovenous malformation 10.4 VEGFA MMP2 KRAS
27 pancreatic intraductal papillary-mucinous neoplasm 10.4 SMAD4 KRAS
28 klatskin's tumor 10.4 MMP2 MACC1 APC
29 pulmonary emphysema 10.4 VEGFA MMP2 CASP3
30 intrahepatic cholangiocarcinoma 10.4 SMAD4 KRAS APC
31 ovarian serous cystadenocarcinoma 10.4 VEGFA SMAD4 KRAS FBXW7
32 limb ischemia 10.4 VEGFA MMP2 MIR503
33 cholangiocarcinoma 10.4 SMAD4 OGG1 KRAS APC
34 aortic aneurysm, familial thoracic 1 10.3 SMAD4 SMAD3 MMP2
35 autosomal dominant non-syndromic intellectual disability 19 10.3 SMAD4 SMAD3
36 serous cystadenocarcinoma 10.3 VEGFA MMP2 KRAS FBXW7
37 central nervous system cancer 10.3 VEGFA MIR182 EGF APC
38 intestinal benign neoplasm 10.3 VEGFA SMAD4 LGR5 KRAS APC
39 tongue disease 10.3 VEGFA MMP2 EGF CASP3
40 cell type benign neoplasm 10.3 VEGFA SMAD4 LGR5 KRAS APC
41 tumor of exocrine pancreas 10.3 SMAD4 KRAS
42 odontogenic myxoma 10.3 VEGFA MMP2
43 tongue squamous cell carcinoma 10.3 VEGFA MMP2 EGF CASP3
44 cervical squamous cell carcinoma 10.3 VEGFA MMP2 KRAS
45 pancreas disease 10.3 VEGFA SMAD4 MIR182 KRAS
46 malignant glioma 10.3 VEGFA MMP2 EGF CASP3
47 ovarian disease 10.3 VEGFA KRAS EGF CASP3
48 ovary adenocarcinoma 10.3 VEGFA SMAD4 KRAS EGF CASP3
49 glioma susceptibility 1 10.2 VEGFA MMP2 MIR182 CASP3
50 aortic disease 10.2 SMAD4 SMAD3 MMP2

Graphical network of the top 20 diseases related to Colon Adenoma:



Diseases related to Colon Adenoma

Symptoms & Phenotypes for Colon Adenoma

MGI Mouse Phenotypes related to Colon Adenoma:

45 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.42 APC CASP3 DKK1 FBXW7 KRAS LGR5
2 growth/size/body region MP:0005378 10.41 APC CASP3 CTBP1 DKK1 EGF FBXW7
3 cardiovascular system MP:0005385 10.39 APC CASP3 CTBP1 FBXW7 KRAS MMP2
4 homeostasis/metabolism MP:0005376 10.39 APC CASP3 DKK1 FBXW7 KRAS LGR5
5 craniofacial MP:0005382 10.38 APC CASP3 DKK1 FBXW7 KRAS LGR5
6 digestive/alimentary MP:0005381 10.37 APC CASP3 EGF FBXW7 KRAS LGR5
7 endocrine/exocrine gland MP:0005379 10.35 APC CASP3 EGF FBXW7 KRAS LGR5
8 immune system MP:0005387 10.35 APC CASP3 EGF FBXW7 KRAS MMP2
9 hematopoietic system MP:0005397 10.34 APC CASP3 FBXW7 KRAS MMP2 OGG1
10 mortality/aging MP:0010768 10.32 APC CASP3 CTBP1 DKK1 FBXW7 KRAS
11 integument MP:0010771 10.26 APC CASP3 EGF FBXW7 KRAS LGR5
12 embryo MP:0005380 10.24 APC CTBP1 DKK1 FBXW7 KRAS RXRA
13 nervous system MP:0003631 10.22 APC CASP3 CTBP1 DKK1 FBXW7 KRAS
14 neoplasm MP:0002006 10.17 APC FBXW7 KRAS LGR5 MMP2 OGG1
15 limbs/digits/tail MP:0005371 10.16 APC DKK1 KRAS RBP4 RXRA SMAD3
16 muscle MP:0005369 10.16 APC CASP3 CTBP1 KRAS MMP2 RBP4
17 liver/biliary system MP:0005370 10.1 APC FBXW7 KRAS OGG1 RXRA SMAD3
18 normal MP:0002873 10.07 APC EGF FBXW7 KRAS MMP2 OGG1
19 renal/urinary system MP:0005367 10.06 APC CASP3 DKK1 KRAS LGR5 RBP4
20 reproductive system MP:0005389 9.96 APC CASP3 EGF KRAS RBP4 RXRA
21 respiratory system MP:0005388 9.76 CASP3 DKK1 FBXW7 KRAS LGR5 MMP2
22 skeleton MP:0005390 9.73 APC CASP3 CTBP1 DKK1 KRAS MMP2
23 vision/eye MP:0005391 9.36 APC CASP3 DKK1 EGF FBXW7 KRAS

Drugs & Therapeutics for Colon Adenoma

Drugs for Colon Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Antineoplastic Agents, Immunological Phase 2
3 Liver Extracts
4 Cola

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Prospective, Multicenter Study for the Evaluation of Safety and Performance of the Interscope EndoRotor Endoscopic Mucosal Resection System for the Removal of Alimentary Tract Mucosa in the Colon Recruiting NCT04203667 Phase 4
2 A Phase II Study of PD-1 Inhibition for the Prevention of Colon Adenomas in Patients With Lynch Syndrome and a History of Partial Colectomy Suspended NCT03631641 Phase 2
3 Usefulness of Fecal Calprotectin for Screening Colon Adenoma in Korean Population Unknown status NCT01719198
4 Computer-assisted Detection of Colonic Polyps Unknown status NCT02838888
5 LCI (Linked Color Imaging) for Adenoma Detection in the Right Colon Unknown status NCT03279783
6 Impact of Diverticular Disease on the Detection of Colon Adenomas Unknown status NCT02057562
7 Effect of a Tracking Program on Colon Adenoma Surveillance and Adherence to Guideline Recommendations Unknown status NCT01713881
8 A Randomized Controlled Trial Comparing High-definition White Light Colonoscopy to I-scan Enhanced Colonoscopy for Adenoma Detection in a Population at Increased Risk of Colorectal Cancer (Main Study) Unknown status NCT02016326
9 Side Specific Withdrawal Times for Colonoscopy: Impact on Adenoma Detection in the Proximal and Distal Colon Completed NCT02819492
10 Impact of Second Forward View Examination of Proximal Colon on Adenoma Detection Rate: A Randomized Clinical Trial Completed NCT03619122
11 Effect of Video Monitor Size on Adenoma Detection Rate Completed NCT01952418
12 Familial Factors in the Development of Colon Cancer Completed NCT00055848
13 Single Center Prospective Evaluation Utilizing a Double Balloon Accessory Device to Facilitate Complex Endoscopic Polypectomy in Large Intestine Completed NCT03551379
14 Linked Color Imaging (LCI) Versus Standard White-light Colonoscopy for Colorectal Adenoma Detection: a Multicenter, Randomized, Trial Completed NCT03690297
15 Accuracy of the Optical Diagnosis of Small Colonic Polyps Using the Nice Classification Completed NCT02009774
16 Comparing Right Colon Adenoma and Hyperplastic Polyp Miss Rate in Colonoscopy Using Water Exchange and Carbon Dioxide Insufflation: A Prospective Randomized Controlled Trial Completed NCT03845933
17 Tandem Colonoscopy Study of Linked Color Imaging Versus Narrow Band Imaging on Colorectal Adenoma Detection: A Prospective, Randomized Study Completed NCT03336359
18 Comparison of Colon Adenoma Detection Rate Using Two Distal Colonoscope Attachments Completed NCT02665741
19 Endoscopic Evaluation in Transplantation Candidates - Frequency and Prognostic Relevance of Upper and Lower Gastrointestinal Tract Findings Completed NCT00990470
20 A Clinical Validation Study of Two Computerized Systems Called the 3D-Colonoscopy Progression Score and 3D-Colonoscopy Retraction Score Completed NCT03587935
21 Multi-center Prospective Registry Study Utilizing a Double Balloon Accessory Device to Facilitate Endoscopic Polypectomy in Large Intestine. Recruiting NCT03942965
22 The Utility of Time Segmental Withdrawal During Screening Colonoscopy for Increasing Adenoma Detection Rate. A Randomized Controlled Clinical Trial. Recruiting NCT02538406
23 Prospective Randomized Control Trial (RCT) of Water Exchange (WE) vs. WE Plus Cap-assisted Colonoscopy Recruiting NCT03543124
24 Comparing Right Colon Adenoma and Hyperplastic Polyp Miss Rates in Colonoscopy Using Water Exchange and CO2 Insufflation: A Multicenter Randomized Tandem Study Recruiting NCT04124393
25 Trainee Participation Increases Colon Adenoma Detection Rate: a Randomized Controlled Trial Recruiting NCT03908229
26 Blue Laser Imaging Versus Narrow Band Imaging Versus White Light Imaging for Detection of Adenoma in the Proximal Colon: A Prospective Randomized Study Recruiting NCT03696992
27 The Australian Colonic Large Sessile Lesion Endoscopic Resection Study Recruiting NCT03471793
28 PLA Army General Hospital of Beijing Recruiting NCT03781648
29 Correlation Between Surrogate Quality Indicators for Adenoma Detection Rate (ADR) and Adenoma Miss Rate (AMR) in Qualified Colonoscopy: CORE Study Recruiting NCT03919487
30 Risk Factors of Inadequate Bowel Cleansing in Inpatients: a Predictive Score Not yet recruiting NCT03902561
31 NBI Versus White Light Endoscopy for Optical Characterization of Neoplastic Polyps in the Colorectum - the ADOPTION II Study Not yet recruiting NCT03679429
32 Risk Factors of Inadequate Bowel Cleansing in Colon Capsule Endoscopy Not yet recruiting NCT03933371

Search NIH Clinical Center for Colon Adenoma

Genetic Tests for Colon Adenoma

Anatomical Context for Colon Adenoma

MalaCards organs/tissues related to Colon Adenoma:

40
Colon, Liver, Pancreas, Skin, Kidney, Thyroid, Myeloid

Publications for Colon Adenoma

Articles related to Colon Adenoma:

(show top 50) (show all 343)
# Title Authors PMID Year
1
Dose-response meta-analysis of coffee consumption and risk of colorectal adenoma. 61
31308476 2020
2
Phospholipid profiling enables to discriminate tumor- and non-tumor-derived human colon epithelial cells: Phospholipidome similarities and differences in colon cancer cell lines and in patient-derived cell samples. 61
31999740 2020
3
Integrated Imaging Methodology Detects Claudin-1 Expression in Premalignant Nonpolypoid and Polypoid Colonic Epithelium in Mice. 61
31922993 2020
4
Cap-Assisted Chromoendoscopy Using a Mounted Cap Versus Standard Colonoscopy for Adenoma Detection. 61
31972618 2020
5
Comparison of colon adenoma detection rates using cap-assisted and Endocuff-assisted colonoscopy: a randomized controlled trial. 61
31788539 2019
6
Prognostic Value of TWIST1 and EZH2 Expression in Colon Cancer. 61
31823218 2019
7
Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15. 61
31389184 2019
8
Intermittent Dosing Regimens of Aspirin and Naproxen Inhibit Azoxymethane-Induced Colon Adenoma Progression to Adenocarcinoma and Invasive Carcinoma. 61
31530543 2019
9
Radiofrequency ablation as an adjunct for recurrent colon adenoma. 61
31733199 2019
10
Compared Abilities of Endoscopic Techniques to Increase Colon Adenoma Detection Rates: A Network Meta-analysis. 61
30529731 2019
11
Microbiota alterations after colon adenoma resection. 61
31726487 2019
12
Obesity, diabetes and the risk of colorectal adenoma and cancer. 61
31664994 2019
13
Randomized control trial of adenoma detection rate in Endocuff-assisted colonoscopy versus transparent hood-assisted colonoscopy. 61
31254485 2019
14
Meta-Analysis of Cancer Triploidy: Rearrangements of Genome Complements in Male Human Tumors Are Characterized by XXY Karyotypes. 61
31412657 2019
15
Antioxidative, Anti-Inflammatory, and Anticancer Effects of Purified Flavonol Glycosides and Aglycones in Green Tea. 61
31387266 2019
16
G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma. 61
29971639 2019
17
Patients with breast cancer may be at higher risk of colorectal neoplasia. 61
31263363 2019
18
[Comparison of endoscopic features between colorectal sessile serrated adenoma/polyp with or without cytologic dysplasia and hyperplastic polyp]. 61
31434395 2019
19
Metaproteomics of fecal samples of Crohn's disease and Ulcerative Colitis. 61
31009805 2019
20
Colon adenoma and adenocarcinoma with clear cell components - two case reports. 61
31077226 2019
21
The benefit of adding oral simethicone in bowel preparation regimen for the detection of colon adenoma: A systematic review and meta-analysis. 61
30311262 2019
22
Tumor response to irinotecan is associated with CYP3A5 expression in colorectal cancer. 61
30881507 2019
23
Redox, immune and genetic biomarker system for personalized treatments in colorectal cancer. 61
30788039 2019
24
Interleukin-37 Inhibits Colon Carcinogensis During Chronic Colitis. 61
31781119 2019
25
The ASAMET trial: a randomized, phase II, double-blind, placebo-controlled, multicenter, 2 × 2 factorial biomarker study of tertiary prevention with low-dose aspirin and metformin in stage I-III colorectal cancer patients. 61
30514262 2018
26
ACTL6A expression promotes invasion, metastasis and epithelial mesenchymal transition of colon cancer. 61
30348114 2018
27
Clonal Structures of Regionally Synchronous Gastric Adenomas and Carcinomas. 61
29945994 2018
28
Clinical Value of CXCL5 for Determining of Colorectal Cancer 61
30255816 2018
29
Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors. 61
29524208 2018
30
Comparative Efficacy of Colonoscope Distal Attachment Devices in Increasing Rates of Adenoma Detection: A Network Meta-analysis. 61
29133257 2018
31
Mutation analysis of adenomas and carcinomas of the colon: Early and late drivers. 61
29575536 2018
32
Evaluation of Patients with an Apparent False Positive Stool DNA Test: The Role of Repeat Stool DNA Testing. 61
29516325 2018
33
Gut immunoglobulin alpha anti-glycan binding profiles as a research tool for local disease detection. 61
29926273 2018
34
Colon adenoma with 2 too-long stalks (with video). 61
29223383 2018
35
Pharmacological and dietary factors in prevention of colorectal cancer. 61
30149368 2018
36
Linked color imaging reduces the miss rate of neoplastic lesions in the right colon: a randomized tandem colonoscopy study. 61
29539651 2018
37
Identification, isolation and characterization of human LGR5-positive colon adenoma cells. 61
29467240 2018
38
Sessile serrated adenoma detection rate is correlated with adenoma detection rate. 61
29564038 2018
39
Influence of roasting on the chemopreventive potential of in vitro fermented almonds in LT97 colon adenoma cells. 61
28583046 2018
40
The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma. 61
29422500 2018
41
Detection rate and proximal shift tendency of adenomas and serrated polyps: a retrospective study of 62,560 colonoscopies. 61
29282495 2018
42
Droplet digital PCR is an accurate method to assess methylation status on FFPE samples. 61
29527977 2018
43
Prevalence and characteristics of colonic adenoma in mainland China. 61
30147371 2018
44
Specific clones of Staphylococcus lugdunensis may be associated with colon carcinoma. 61
28506660 2018
45
Chemopreventive Potential of In Vitro Fermented Raw and Roasted Hazelnuts in LT97 Colon Adenoma Cells. 61
29277760 2018
46
Feasibility of CYFRA 21-1 as a serum biomarker for the detection of colorectal adenoma and advanced colorectal adenoma in people over the age of 45. 61
28186354 2018
47
Different effects of metformin and insulin on primary and secondary chemoprevention of colorectal adenoma in diabetes type 2: Traditional and Bayesian meta-analysis. 61
29383018 2018
48
Adiponectin, Leptin, IGF-1, and Tumor Necrosis Factor Alpha As Potential Serum Biomarkers for Non-Invasive Diagnosis of Colorectal Adenoma in African Americans. 61
29593647 2018
49
Hyperglycemia combined Helicobacter pylori infection increases risk of synchronous colorectal adenoma and carotid artery plaque. 61
29312558 2017
50
TBX19 is overexpressed in colorectal cancer and associated with lymph node metastasis. 61
29199261 2017

Variations for Colon Adenoma

Expression for Colon Adenoma

Search GEO for disease gene expression data for Colon Adenoma.

Pathways for Colon Adenoma

Pathways related to Colon Adenoma according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.13 VEGFA SMAD4 SMAD3 RXRA RBP4 LGR5
2
Show member pathways
13.68 SMAD4 SMAD3 RBP4 KRAS FBXW7 EGF
3
Show member pathways
13.07 SMAD4 SMAD3 RXRA KRAS EGF CASP3
4
Show member pathways
13.04 VDR SMAD4 SMAD3 RXRA KRAS EGF
5
Show member pathways
12.93 VEGFA RXRA KRAS EGF CASP3 APC
6
Show member pathways
12.66 VEGFA SMAD4 SMAD3 RXRA KRAS EGF
7
Show member pathways
12.65 SMAD4 SMAD3 RXRA KRAS EGF APC
8
Show member pathways
12.42 SMAD4 SMAD3 DKK1 APC
9 12.38 VEGFA SMAD4 SMAD3 RXRA MMP2 KRAS
10
Show member pathways
12.37 SMAD4 SMAD3 LGR5 DKK1 CTBP1 APC
11 12.25 VEGFA MMP2 KRAS CASP3
12 12.19 SMAD4 SMAD3 DKK1 APC
13 12.08 VEGFA SMAD4 KRAS CASP3
14 12.02 SMAD4 SMAD3 KRAS APC
15
Show member pathways
12 SMAD4 SMAD3 KRAS EGF
16 11.98 VEGFA LGR5 EGF DKK1
17 11.97 VDR MMP2 DKK1 APC
18 11.89 SMAD4 SMAD3 KRAS APC
19 11.83 SMAD4 SMAD3 KRAS
20 11.69 MMP2 DKK1 CTBP1 APC
21 11.66 VDR SMAD4 SMAD3 CTBP1
22 11.64 SMAD3 MMP2 CASP3
23 11.63 VEGFA SMAD4 SMAD3
24 11.63 VEGFA SMAD4 SMAD3 MMP2 KRAS CASP3
25 11.62 VEGFA MMP2 KRAS EGF
26 11.57 SMAD4 SMAD3 EGF
27 11.56 VEGFA SMAD4 SMAD3 MMP2 CTBP1
28
Show member pathways
11.53 SMAD4 SMAD3 MMP2 EGF
29 11.47 VEGFA EGF DKK1
30 11.44 DKK1 CTBP1 APC
31 11.44 VEGFA SMAD4 SMAD3 MMP2 KRAS EGF
32 11.43 VDR SMAD3 RXRA
33 11.39 VEGFA KRAS EGF
34 11.38 VEGFA SMAD4 SMAD3 CASP3
35 11.1 SMAD4 SMAD3 KRAS APC
36 10.82 VDR RXRA
37 10.81 EGF CASP3
38 10.66 VDR RXRA

GO Terms for Colon Adenoma

Cellular components related to Colon Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor complex GO:0090575 9.33 VDR SMAD4 RXRA
2 receptor complex GO:0043235 9.26 VDR SMAD3 RXRA EGF
3 SMAD protein complex GO:0071141 8.62 SMAD4 SMAD3

Biological processes related to Colon Adenoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.95 VEGFA SMAD3 OGG1 DKK1 CASP3
2 negative regulation of cell proliferation GO:0008285 9.89 VDR SMAD4 SMAD3 CTBP1 APC
3 in utero embryonic development GO:0001701 9.81 VEGFA SMAD4 SMAD3 RXRA
4 negative regulation of transcription by RNA polymerase II GO:0000122 9.8 VEGFA VDR SMAD4 SMAD3 RXRA DKK1
5 lung development GO:0030324 9.73 VEGFA RBP4 FBXW7
6 positive regulation of MAP kinase activity GO:0043406 9.65 VEGFA KRAS EGF
7 response to retinoic acid GO:0032526 9.61 RXRA RBP4 DKK1
8 positive regulation of cell migration GO:0030335 9.55 VEGFA SMAD3 MIR182 EGF APC
9 positive regulation of positive chemotaxis GO:0050927 9.54 VEGFA SMAD3
10 positive regulation of epidermal growth factor-activated receptor activity GO:0045741 9.52 FBXW7 EGF
11 endoderm development GO:0007492 9.5 SMAD4 SMAD3 DKK1
12 SMAD protein complex assembly GO:0007183 9.46 SMAD4 SMAD3
13 regulation of binding GO:0051098 9.4 SMAD4 SMAD3
14 regulation of transforming growth factor beta2 production GO:0032909 9.37 SMAD4 SMAD3
15 response to hypoxia GO:0001666 9.35 VEGFA SMAD4 SMAD3 MMP2 CASP3
16 positive regulation of gene expression GO:0010628 9.17 VEGFA VDR SMAD3 MIR182 KRAS EGF

Molecular functions related to Colon Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 VEGFA SMAD4 SMAD3 RXRA FBXW7 CTBP1
2 growth factor activity GO:0008083 9.46 VEGFA MACC1 EGF DKK1
3 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.35 VDR SMAD4 SMAD3 RXRA MACC1
4 vitamin D response element binding GO:0070644 8.62 VDR RXRA

Sources for Colon Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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