MCID: CLN044
MIFTS: 44

Colon Adenoma

Categories: Cancer diseases, Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Colon Adenoma

MalaCards integrated aliases for Colon Adenoma:

Name: Colon Adenoma 12 15
Adenomatous Polyp of Colon 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050912
UMLS 71 C0850572

Summaries for Colon Adenoma

Disease Ontology : 12 A colonic benign neoplasm that has material basis in epithelial tissue with glandular origin.

MalaCards based summary : Colon Adenoma, also known as adenomatous polyp of colon, is related to adenoma and colorectal adenoma. An important gene associated with Colon Adenoma is APC (APC Regulator Of WNT Signaling Pathway), and among its related pathways/superpathways are Signaling by GPCR and HIV Life Cycle. The drugs Metronidazole and Fosfomycin have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and breast, and related phenotypes are shRNA abundance <= 50% and growth/size/body region

Related Diseases for Colon Adenoma

Diseases related to Colon Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 204)
# Related Disease Score Top Affiliating Genes
1 adenoma 32.2 SMAD4 SMAD3 KRAS APC
2 colorectal adenoma 31.3 VEGFA VDR LGR5 KRAS APC
3 familial adenomatous polyposis 31.2 SMAD4 OGG1 KRAS APC
4 adenocarcinoma 30.9 VEGFA SMAD4 SMAD3 MMP2 KRAS EGF
5 colorectal cancer 30.6 VEGFA VDR SMAD4 SMAD3 OGG1 MMP2
6 lynch syndrome 30.6 SMAD4 OGG1 KRAS APC
7 colon adenocarcinoma 30.0 VEGFA SMAD4 MMP2 KRAS HIF1A EGF
8 sarcoma 30.0 VEGFA KRAS HIF1A CASP3 APC
9 colorectal adenocarcinoma 29.6 VEGFA MMP2 KRAS HIF1A EGF CASP3
10 inflammatory bowel disease 29.4 VEGFA VDR SMAD3 MMP2 KRAS HIF1A
11 leukemia, acute myeloid 29.1 VEGFA SPN KRAS HIF1A HDAC2 H4-16
12 polyposis syndrome, hereditary mixed, 1 11.6
13 familial adenomatous polyposis 4 11.4
14 polyposis syndrome, hereditary mixed, 2 11.3
15 familial adenomatous polyposis 3 11.3
16 attenuated familial adenomatous polyposis 10.6 OGG1 APC
17 hyperplastic polyposis syndrome 10.6 KRAS APC
18 intravascular papillary endothelial hyperplasia 10.6 VEGFA HIF1A
19 ampulla of vater neoplasm 10.5 KRAS APC
20 periampullary adenoma 10.5 KRAS APC
21 myh-associated polyposis 10.5 KRAS APC
22 large intestine adenocarcinoma 10.5 SMAD4 KRAS FBXW7
23 vitreous disease 10.4 VEGFA MMP2 EGF
24 pancreatic ductal carcinoma 10.4 VEGFA SMAD4 EGF
25 retinal ischemia 10.4 VEGFA HIF1A CASP3
26 ischemic colitis 10.4 VEGFA MMP2 HIF1A
27 ovarian clear cell carcinoma 10.4 VEGFA KRAS HIF1A
28 nephrosclerosis 10.4 VEGFA HIF1A CASP3
29 lymphangioma 10.4 VEGFA LGR5 KRAS APC
30 pre-malignant neoplasm 10.4 VEGFA KRAS EGF
31 colonic benign neoplasm 10.4 SMAD4 LGR5 KRAS APC
32 endometrial adenocarcinoma 10.4 VEGFA KRAS EGF
33 arteriovenous malformation 10.4 VEGFA MMP2 KRAS
34 cell type benign neoplasm 10.4 VEGFA SMAD4 KRAS APC
35 pulmonary emphysema 10.4 VEGFA MMP2 CASP3
36 estrogen-receptor positive breast cancer 10.4 VEGFA HIF1A EGF
37 cholangiocarcinoma 10.4 SMAD4 OGG1 KRAS APC
38 osteonecrosis 10.4 VEGFA HIF1A DKK1
39 serous cystadenocarcinoma 10.4 VEGFA MMP2 KRAS FBXW7
40 peutz-jeghers syndrome 10.3 SMAD4 HIF1A APC
41 cervical adenocarcinoma 10.3 KRAS EGF CASP3
42 aortic aneurysm, familial thoracic 1 10.3 SMAD4 SMAD3 MMP2
43 retinal vascular disease 10.3 VEGFA HIF1A CASP3
44 gastrointestinal system benign neoplasm 10.3 LGR5 KRAS APC
45 cervical squamous cell carcinoma 10.3 VEGFA MMP2 KRAS HIF1A
46 intestinal benign neoplasm 10.3 VEGFA SMAD4 LGR5 KRAS APC
47 autonomic nervous system neoplasm 10.3 VEGFA HIF1A EGF CASP3
48 peripheral nervous system neoplasm 10.3 VEGFA HIF1A EGF CASP3
49 spinal disease 10.3 VEGFA HIF1A EGF CASP3
50 varicose veins 10.3 VEGFA MMP2 HIF1A

Graphical network of the top 20 diseases related to Colon Adenoma:



Diseases related to Colon Adenoma

Symptoms & Phenotypes for Colon Adenoma

GenomeRNAi Phenotypes related to Colon Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.17 FBXW7 KRAS LGR5 MMP2 OGG1 RXRA

MGI Mouse Phenotypes related to Colon Adenoma:

45 (show all 25)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.48 APC CASP3 CTBP1 DKK1 EGF FBXW7
2 cellular MP:0005384 10.46 APC CASP3 DKK1 FBXW7 HDAC2 HIF1A
3 behavior/neurological MP:0005386 10.44 APC CASP3 HDAC2 HIF1A KRAS LGR5
4 cardiovascular system MP:0005385 10.43 APC CASP3 CTBP1 FBXW7 HDAC2 HIF1A
5 homeostasis/metabolism MP:0005376 10.43 APC CASP3 DKK1 FBXW7 HDAC2 HIF1A
6 craniofacial MP:0005382 10.42 APC CASP3 DKK1 FBXW7 HIF1A KRAS
7 immune system MP:0005387 10.42 APC CASP3 EGF FBXW7 HDAC2 HIF1A
8 digestive/alimentary MP:0005381 10.41 APC CASP3 EGF FBXW7 HDAC2 HIF1A
9 hematopoietic system MP:0005397 10.41 APC CASP3 FBXW7 HDAC2 HIF1A KRAS
10 endocrine/exocrine gland MP:0005379 10.4 APC CASP3 EGF FBXW7 HDAC2 HIF1A
11 mortality/aging MP:0010768 10.4 APC CASP3 CTBP1 DKK1 FBXW7 HDAC2
12 integument MP:0010771 10.35 APC CASP3 EGF FBXW7 HDAC2 HIF1A
13 nervous system MP:0003631 10.31 APC CASP3 CTBP1 DKK1 FBXW7 HDAC2
14 embryo MP:0005380 10.29 APC CTBP1 DKK1 FBXW7 HIF1A KRAS
15 neoplasm MP:0002006 10.27 APC FBXW7 HDAC2 HIF1A KRAS LGR5
16 limbs/digits/tail MP:0005371 10.22 APC DKK1 HDAC2 HIF1A KRAS RXRA
17 muscle MP:0005369 10.22 APC CASP3 CTBP1 HDAC2 HIF1A KRAS
18 liver/biliary system MP:0005370 10.16 APC FBXW7 HIF1A KRAS OGG1 RXRA
19 normal MP:0002873 10.14 APC EGF FBXW7 HDAC2 HIF1A KRAS
20 renal/urinary system MP:0005367 10.06 APC CASP3 DKK1 HIF1A KRAS LGR5
21 reproductive system MP:0005389 9.96 APC CASP3 EGF HDAC2 KRAS RXRA
22 respiratory system MP:0005388 9.85 CASP3 DKK1 FBXW7 HDAC2 HIF1A KRAS
23 pigmentation MP:0001186 9.77 APC CASP3 HDAC2 KRAS RXRA
24 skeleton MP:0005390 9.77 APC CASP3 CTBP1 DKK1 HDAC2 HIF1A
25 vision/eye MP:0005391 9.4 APC CASP3 DKK1 EGF FBXW7 HDAC2

Drugs & Therapeutics for Colon Adenoma

Drugs for Colon Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved Phase 2 443-48-1 4173
2
Fosfomycin Approved Phase 2 23155-02-4 446987
3
nivolumab Approved Phase 2 946414-94-4
4 Antiparasitic Agents Phase 2
5 Antiprotozoal Agents Phase 2
6 Anti-Bacterial Agents Phase 2
7 Anti-Infective Agents Phase 2
8 Antineoplastic Agents, Immunological Phase 2
9 Liver Extracts
10 Cola

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Prospective, Multicenter Study for the Evaluation of Safety and Performance of the Interscope EndoRotor Endoscopic Mucosal Resection System for the Removal of Alimentary Tract Mucosa in the Colon Completed NCT04203667 Phase 4
2 Preoperative Endoscopic Treatment With Fosfomycin and Metronidazole in Patients With Right-sided Colon Cancer and Colon Adenoma: a Clinical Proof-of-concept Intervention Study MEFO Trial Recruiting NCT04312360 Phase 2 therapeutic endoscopy with metronidazole and fosfomycin disodium
3 A Phase II Study of PD-1 Inhibition for the Prevention of Colon Adenomas in Patients With Lynch Syndrome and a History of Partial Colectomy Active, not recruiting NCT03631641 Phase 2
4 Usefulness of Fecal Calprotectin for Screening Colon Adenoma in Korean Population Unknown status NCT01719198
5 Computer-assisted Detection of Colonic Polyps Unknown status NCT02838888
6 LCI (Linked Color Imaging) for Adenoma Detection in the Right Colon Unknown status NCT03279783
7 Impact of Diverticular Disease on the Detection of Colon Adenomas Unknown status NCT02057562
8 Effect of a Tracking Program on Colon Adenoma Surveillance and Adherence to Guideline Recommendations Unknown status NCT01713881
9 A Randomized Controlled Trial Comparing High-definition White Light Colonoscopy to I-scan Enhanced Colonoscopy for Adenoma Detection in a Population at Increased Risk of Colorectal Cancer (Main Study) Unknown status NCT02016326
10 Side Specific Withdrawal Times for Colonoscopy: Impact on Adenoma Detection in the Proximal and Distal Colon Completed NCT02819492
11 Impact of Second Forward View Examination of Proximal Colon on Adenoma Detection Rate: A Randomized Clinical Trial Completed NCT03619122
12 Effect of Video Monitor Size on Adenoma Detection Rate Completed NCT01952418
13 Familial Factors in the Development of Colon Cancer Completed NCT00055848
14 Single Center Prospective Evaluation Utilizing a Double Balloon Accessory Device to Facilitate Complex Endoscopic Polypectomy in Large Intestine Completed NCT03551379
15 Trainee Participation Increases Colon Adenoma Detection Rate: a Randomized Controlled Trial Completed NCT03908229
16 Linked Color Imaging (LCI) Versus Standard White-light Colonoscopy for Colorectal Adenoma Detection: a Multicenter, Randomized, Trial Completed NCT03690297
17 Artificial Intelligence-Assisted Real-time Detection of Missed Lesions During Colonoscopy: A Prospective Study Completed NCT04227795
18 Accuracy of the Optical Diagnosis of Small Colonic Polyps Using the Nice Classification Completed NCT02009774
19 Comparing Right Colon Adenoma and Hyperplastic Polyp Miss Rate in Colonoscopy Using Water Exchange and Carbon Dioxide Insufflation: A Prospective Randomized Controlled Trial Completed NCT03845933
20 Comparison of Colon Adenoma Detection Rate Using Two Distal Colonoscope Attachments Completed NCT02665741
21 Tandem Colonoscopy Study of Linked Color Imaging Versus Narrow Band Imaging on Colorectal Adenoma Detection: A Prospective, Randomized Study Completed NCT03336359
22 Endoscopic Evaluation in Transplantation Candidates - Frequency and Prognostic Relevance of Upper and Lower Gastrointestinal Tract Findings Completed NCT00990470
23 A Clinical Validation Study of Two Computerized Systems Called the 3D-Colonoscopy Progression Score and 3D-Colonoscopy Retraction Score Completed NCT03587935
24 Multi-center Prospective Registry Study Utilizing a Double Balloon Accessory Device to Facilitate Endoscopic Polypectomy in Large Intestine. Recruiting NCT03942965
25 Prospective Randomized Control Trial (RCT) of Water Exchange (WE) vs. WE Plus Cap-assisted Colonoscopy Recruiting NCT03543124
26 Comparing Right Colon Adenoma and Hyperplastic Polyp Miss Rates in Colonoscopy Using Water Exchange and CO2 Insufflation: A Multicenter Randomized Tandem Study Recruiting NCT04124393
27 Blue Laser Imaging Versus Narrow Band Imaging Versus White Light Imaging for Detection of Adenoma in the Proximal Colon: A Prospective Randomized Study Recruiting NCT03696992
28 The Australian Colonic Large Sessile Lesion Endoscopic Resection Study Recruiting NCT03471793
29 PLA Army General Hospital of Beijing Recruiting NCT03781648
30 Correlation Between Surrogate Quality Indicators for Adenoma Detection Rate (ADR) and Adenoma Miss Rate (AMR) in Qualified Colonoscopy: CORE Study Recruiting NCT03919487
31 Artificial Intelligence-assisted Colonoscopy Versus Conventional Colonoscopy for Missed Lesions in the Proximal Colon: A Prospective Multi-center Randomized Study in Asia Not yet recruiting NCT04294355
32 Risk Factors of Inadequate Bowel Cleansing in Inpatients: a Predictive Score Not yet recruiting NCT03902561
33 Risk Factors of Inadequate Bowel Cleansing in Colon Capsule Endoscopy Not yet recruiting NCT03933371
34 NBI Versus White Light Endoscopy for Optical Characterization of Neoplastic Polyps in the Colorectum - the ADOPTION II Study Not yet recruiting NCT03679429
35 The Utility of Time Segmental Withdrawal During Screening Colonoscopy for Increasing Adenoma Detection Rate. A Randomized Controlled Clinical Trial. Suspended NCT02538406

Search NIH Clinical Center for Colon Adenoma

Genetic Tests for Colon Adenoma

Anatomical Context for Colon Adenoma

MalaCards organs/tissues related to Colon Adenoma:

40
Colon, Liver, Breast, Testes, Lymph Node, Pancreas, Skin

Publications for Colon Adenoma

Articles related to Colon Adenoma:

(show top 50) (show all 348)
# Title Authors PMID Year
1
Chemopreventive effects of raw and roasted oat flakes after in vitro fermentation with human faecal microbiota. 61
32482126 2020
2
Impact of Fellow Participation on Colon Adenoma Detection Rates: A Multicenter Randomized Trial. 61
32433915 2020
3
Radiofrequency ablation as an adjunct for recurrent colon adenoma. 61
31733199 2020
4
Cap-Assisted Chromoendoscopy Using a Mounted Cap Versus Standard Colonoscopy for Adenoma Detection. 61
31972618 2020
5
Study on chemopreventive effects of raw and roasted β-glucan-rich waxy winter barley using an in vitro human colon digestion model. 61
32176229 2020
6
Dose-response meta-analysis of coffee consumption and risk of colorectal adenoma. 61
31308476 2020
7
Phospholipid profiling enables to discriminate tumor- and non-tumor-derived human colon epithelial cells: Phospholipidome similarities and differences in colon cancer cell lines and in patient-derived cell samples. 61
31999740 2020
8
Integrated Imaging Methodology Detects Claudin-1 Expression in Premalignant Nonpolypoid and Polypoid Colonic Epithelium in Mice. 61
31922993 2020
9
A circulating extracellular vesicles-based novel screening tool for colorectal cancer revealed by shotgun and data-independent acquisition mass spectrometry. 61
32363013 2020
10
Comparison of colon adenoma detection rates using cap-assisted and Endocuff-assisted colonoscopy: a randomized controlled trial. 61
31788539 2019
11
Prognostic Value of TWIST1 and EZH2 Expression in Colon Cancer. 61
31823218 2019
12
Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15. 61
31389184 2019
13
Intermittent Dosing Regimens of Aspirin and Naproxen Inhibit Azoxymethane-Induced Colon Adenoma Progression to Adenocarcinoma and Invasive Carcinoma. 61
31530543 2019
14
Compared Abilities of Endoscopic Techniques to Increase Colon Adenoma Detection Rates: A Network Meta-analysis. 61
30529731 2019
15
Microbiota alterations after colon adenoma resection. 61
31726487 2019
16
Obesity, diabetes and the risk of colorectal adenoma and cancer. 61
31664994 2019
17
Randomized control trial of adenoma detection rate in Endocuff-assisted colonoscopy versus transparent hood-assisted colonoscopy. 61
31254485 2019
18
Meta-Analysis of Cancer Triploidy: Rearrangements of Genome Complements in Male Human Tumors Are Characterized by XXY Karyotypes. 61
31412657 2019
19
Antioxidative, Anti-Inflammatory, and Anticancer Effects of Purified Flavonol Glycosides and Aglycones in Green Tea. 61
31387266 2019
20
G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma. 61
29971639 2019
21
Patients with breast cancer may be at higher risk of colorectal neoplasia. 61
31263363 2019
22
[Comparison of endoscopic features between colorectal sessile serrated adenoma/polyp with or without cytologic dysplasia and hyperplastic polyp]. 61
31434395 2019
23
Metaproteomics of fecal samples of Crohn's disease and Ulcerative Colitis. 61
31009805 2019
24
Colon adenoma and adenocarcinoma with clear cell components - two case reports. 61
31077226 2019
25
The benefit of adding oral simethicone in bowel preparation regimen for the detection of colon adenoma: A systematic review and meta-analysis. 61
30311262 2019
26
Synchronous Duodenal Adenocarcinoma and Colon Adenoma Following with Lynch Syndrome Requiring Pancreaticoduodenectomy and Completion Total Colectomy with Ileorectal Anastomosis. 61
32432215 2019
27
Tumor response to irinotecan is associated with CYP3A5 expression in colorectal cancer. 61
30881507 2019
28
Redox, immune and genetic biomarker system for personalized treatments in colorectal cancer. 61
30788039 2019
29
Interleukin-37 Inhibits Colon Carcinogensis During Chronic Colitis. 61
31781119 2019
30
The ASAMET trial: a randomized, phase II, double-blind, placebo-controlled, multicenter, 2 × 2 factorial biomarker study of tertiary prevention with low-dose aspirin and metformin in stage I-III colorectal cancer patients. 61
30514262 2018
31
ACTL6A expression promotes invasion, metastasis and epithelial mesenchymal transition of colon cancer. 61
30348114 2018
32
Clonal Structures of Regionally Synchronous Gastric Adenomas and Carcinomas. 61
29945994 2018
33
Clinical Value of CXCL5 for Determining of Colorectal Cancer 61
30255816 2018
34
Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors. 61
29524208 2018
35
Comparative Efficacy of Colonoscope Distal Attachment Devices in Increasing Rates of Adenoma Detection: A Network Meta-analysis. 61
29133257 2018
36
Mutation analysis of adenomas and carcinomas of the colon: Early and late drivers. 61
29575536 2018
37
Gut immunoglobulin alpha anti-glycan binding profiles as a research tool for local disease detection. 61
29926273 2018
38
Evaluation of Patients with an Apparent False Positive Stool DNA Test: The Role of Repeat Stool DNA Testing. 61
29516325 2018
39
Colon adenoma with 2 too-long stalks (with video). 61
29223383 2018
40
Pharmacological and dietary factors in prevention of colorectal cancer. 61
30149368 2018
41
Linked color imaging reduces the miss rate of neoplastic lesions in the right colon: a randomized tandem colonoscopy study. 61
29539651 2018
42
Identification, isolation and characterization of human LGR5-positive colon adenoma cells. 61
29467240 2018
43
Sessile serrated adenoma detection rate is correlated with adenoma detection rate. 61
29564038 2018
44
The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma. 61
29422500 2018
45
Influence of roasting on the chemopreventive potential of in vitro fermented almonds in LT97 colon adenoma cells. 61
28583046 2018
46
Detection rate and proximal shift tendency of adenomas and serrated polyps: a retrospective study of 62,560 colonoscopies. 61
29282495 2018
47
Specific clones of Staphylococcus lugdunensis may be associated with colon carcinoma. 61
28506660 2018
48
Prevalence and characteristics of colonic adenoma in mainland China. 61
30147371 2018
49
Droplet digital PCR is an accurate method to assess methylation status on FFPE samples. 61
29527977 2018
50
Chemopreventive Potential of In Vitro Fermented Raw and Roasted Hazelnuts in LT97 Colon Adenoma Cells. 61
29277760 2018

Variations for Colon Adenoma

Expression for Colon Adenoma

Search GEO for disease gene expression data for Colon Adenoma.

Pathways for Colon Adenoma

Pathways related to Colon Adenoma according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.09 VEGFA SMAD4 SMAD3 RXRA LGR5 KRAS
2
Show member pathways
13.72 SMAD4 SMAD3 KRAS HDAC2 FBXW7 EGF
3
Show member pathways
13.49 VEGFA SMAD4 SMAD3 RXRA MMP2 KRAS
4
Show member pathways
13.09 VDR SMAD4 SMAD3 RXRA KRAS EGF
5
Show member pathways
13.05 SMAD4 SMAD3 RXRA KRAS EGF CASP3
6
Show member pathways
12.96 VEGFA RXRA KRAS HDAC2 EGF CASP3
7
Show member pathways
12.74 SMAD4 SMAD3 RXRA KRAS EGF APC
8
Show member pathways
12.6 VEGFA SMAD4 SMAD3 RXRA KRAS HDAC2
9 12.52 VEGFA KRAS HDAC2 CASP3 APC
10
Show member pathways
12.52 SMAD3 HIF1A HDAC2 H4-16 FBXW7 CTBP1
11
Show member pathways
12.45 SMAD4 SMAD3 DKK1 APC
12
Show member pathways
12.45 VEGFA SMAD4 SMAD3 KRAS EGF CASP3
13
Show member pathways
12.39 SMAD4 SMAD3 LGR5 DKK1 CTBP1 APC
14 12.36 SMAD4 SMAD3 HDAC2 APC
15
Show member pathways
12.31 SMAD3 MMP2 EGF APC
16 12.29 KRAS HDAC2 H4-16 CASP3
17
Show member pathways
12.29 VEGFA KRAS HIF1A CASP3
18 12.29 VEGFA MMP2 KRAS HIF1A CASP3
19 12.23 SMAD4 SMAD3 DKK1 APC
20
Show member pathways
12.19 RXRA HDAC2 H4-16 FBXW7
21 12.14 VEGFA SMAD4 KRAS CASP3
22 12.13 VEGFA SMAD4 SMAD3 RXRA MMP2 KRAS
23 12.09 SMAD4 SMAD3 KRAS APC
24
Show member pathways
12.07 SMAD4 SMAD3 KRAS EGF
25 12.05 VEGFA LGR5 EGF DKK1
26 12.01 VDR MMP2 HDAC2 DKK1 APC
27 12 RXRA KRAS HIF1A HDAC2
28 11.96 SMAD4 SMAD3 KRAS APC
29 11.87 SMAD4 SMAD3 KRAS
30 11.78 VEGFA SMAD4 SMAD3 MMP2 KRAS EGF
31 11.73 VEGFA MMP2 KRAS EGF
32 11.73 MMP2 HDAC2 DKK1 CTBP1 APC
33 11.73 VEGFA SMAD4 SMAD3 MMP2 KRAS CASP3
34
Show member pathways
11.71 VEGFA HIF1A CTBP1
35 11.69 SMAD3 HDAC2 EGF
36 11.69 VDR SMAD4 SMAD3 HDAC2 CTBP1
37 11.68 SMAD3 MMP2 HIF1A CASP3
38 11.66 VEGFA SMAD4 SMAD3 HIF1A
39 11.63 HDAC2 FBXW7 CTBP1
40 11.61 SMAD4 SMAD3 EGF
41
Show member pathways
11.6 SMAD4 SMAD3 MMP2 EGF
42 11.58 VEGFA SMAD4 SMAD3 MMP2 HDAC2 CTBP1
43 11.52 VEGFA EGF DKK1
44 11.49 DKK1 CTBP1 APC
45 11.48 VDR SMAD3 RXRA
46 11.45 VEGFA KRAS EGF
47 11.43 VEGFA SMAD4 SMAD3 HIF1A CASP3
48 11.34 RXRA HDAC2 CASP3
49 11.23 SMAD4 SMAD3 KRAS APC
50 10.86 VDR RXRA

GO Terms for Colon Adenoma

Cellular components related to Colon Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.21 VDR SPN SMAD4 SMAD3 RXRA OGG1
2 nuclear chromatin GO:0000790 9.88 VDR SMAD4 SMAD3 RXRA HIF1A HDAC2
3 nucleoplasm GO:0005654 9.73 VDR SMAD4 SMAD3 RXRA OGG1 HIF1A
4 protein-containing complex GO:0032991 9.63 SMAD3 RXRA OGG1 HIF1A HDAC2 H4-16
5 receptor complex GO:0043235 9.62 VDR SMAD3 RXRA EGF
6 SMAD protein complex GO:0071141 9.26 SMAD4 SMAD3
7 RNA polymerase II transcription factor complex GO:0090575 8.92 VDR SMAD4 RXRA HIF1A

Biological processes related to Colon Adenoma according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.09 VEGFA VDR SMAD4 SMAD3 RXRA HIF1A
2 positive regulation of transcription, DNA-templated GO:0045893 9.97 SMAD4 SMAD3 RXRA HIF1A HDAC2 EGF
3 negative regulation of cell proliferation GO:0008285 9.96 VDR SMAD4 SMAD3 CTBP1 APC
4 negative regulation of transcription by RNA polymerase II GO:0000122 9.92 VEGFA VDR SMAD4 SMAD3 RXRA HDAC2
5 protein deubiquitination GO:0016579 9.91 SMAD4 SMAD3 HIF1A APC
6 angiogenesis GO:0001525 9.9 VEGFA MMP2 HIF1A EGF
7 positive regulation of cell migration GO:0030335 9.88 VEGFA SMAD3 EGF APC
8 in utero embryonic development GO:0001701 9.88 VEGFA SMAD4 SMAD3 RXRA
9 cytokine-mediated signaling pathway GO:0019221 9.8 VEGFA MMP2 KRAS HIF1A CASP3
10 negative regulation of apoptotic process GO:0043066 9.8 VEGFA SMAD3 OGG1 HIF1A HDAC2 DKK1
11 positive regulation of MAP kinase activity GO:0043406 9.71 VEGFA KRAS EGF
12 positive regulation of gene expression GO:0010628 9.7 VEGFA VDR SMAD3 KRAS HIF1A EGF
13 lactation GO:0007595 9.65 VEGFA VDR HIF1A
14 positive regulation of epithelial to mesenchymal transition GO:0010718 9.63 SMAD4 SMAD3 HDAC2
15 positive regulation of epidermal growth factor-activated receptor activity GO:0045741 9.61 FBXW7 EGF
16 positive regulation of positive chemotaxis GO:0050927 9.59 VEGFA SMAD3
17 positive regulation of receptor biosynthetic process GO:0010870 9.57 HIF1A HDAC2
18 endoderm development GO:0007492 9.54 SMAD4 SMAD3 DKK1
19 SMAD protein complex assembly GO:0007183 9.52 SMAD4 SMAD3
20 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.51 VEGFA HIF1A
21 regulation of binding GO:0051098 9.43 SMAD4 SMAD3
22 regulation of transforming growth factor beta2 production GO:0032909 9.13 SMAD4 SMAD3 HIF1A
23 response to hypoxia GO:0001666 9.1 VEGFA SMAD4 SMAD3 MMP2 HIF1A CASP3

Molecular functions related to Colon Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.28 VEGFA VDR SMAD4 SMAD3 RXRA OGG1
2 sequence-specific DNA binding GO:0043565 9.73 VDR SMAD4 SMAD3 RXRA HIF1A HDAC2
3 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.55 VDR SMAD4 SMAD3 RXRA HIF1A
4 transcription factor binding GO:0008134 9.1 VDR SMAD3 RXRA HIF1A HDAC2 CTBP1
5 vitamin D response element binding GO:0070644 8.96 VDR RXRA

Sources for Colon Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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