MCID: CLN044
MIFTS: 44

Colon Adenoma

Categories: Cancer diseases, Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Colon Adenoma

MalaCards integrated aliases for Colon Adenoma:

Name: Colon Adenoma 12 15
Adenomatous Polyp of Colon 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050912
UMLS 71 C0850572

Summaries for Colon Adenoma

Disease Ontology : 12 A colonic benign neoplasm that has material basis in epithelial tissue with glandular origin.

MalaCards based summary : Colon Adenoma, also known as adenomatous polyp of colon, is related to adenoma and colorectal adenoma. An important gene associated with Colon Adenoma is APC (APC Regulator Of WNT Signaling Pathway), and among its related pathways/superpathways are Signaling by GPCR and HIV Life Cycle. The drugs Scopolamine and Anticonvulsants have been mentioned in the context of this disorder. Affiliated tissues include colon, breast and lymph node, and related phenotypes are shRNA abundance <= 50% and growth/size/body region

Related Diseases for Colon Adenoma

Diseases related to Colon Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 adenoma 31.5 SMAD4 SMAD3 KRAS APC
2 colorectal adenoma 30.8 VEGFA VDR KRAS CYP2C9 APC
3 familial adenomatous polyposis 30.5 SMAD4 OGG1 KRAS APC
4 adenocarcinoma 30.5 VEGFA SMAD4 SMAD3 MMP2 KRAS EGF
5 colon adenocarcinoma 30.1 VEGFA SMAD4 KRAS HIF1A EGF CASP3
6 lynch syndrome 29.7 SMAD4 OGG1 KRAS APC
7 colorectal cancer 28.2 VEGFA VDR SMAD4 SMAD3 OGG1 MMP2
8 intravascular papillary endothelial hyperplasia 10.5 VEGFA HIF1A
9 ischemic colitis 10.4 VEGFA MMP2 HIF1A
10 ampulla of vater neoplasm 10.4 KRAS APC
11 oral submucous fibrosis 10.4 VEGFA MMP2 HIF1A
12 periampullary adenoma 10.4 KRAS APC
13 limb ischemia 10.4 VEGFA MMP2 HIF1A
14 retinal ischemia 10.3 VEGFA HIF1A CASP3
15 ovarian clear cell carcinoma 10.3 VEGFA KRAS HIF1A
16 nephrosclerosis 10.3 VEGFA HIF1A CASP3
17 varicose veins 10.3 VEGFA MMP2 HIF1A
18 serrated polyposis syndrome 10.3 KRAS APC
19 differentiated thyroid carcinoma 10.3 VEGFA VDR MMP2 KRAS
20 soft tissue sarcoma 10.3 VEGFA HIF1A
21 colonic benign neoplasm 10.3 LGR5 KRAS APC
22 ovary adenocarcinoma 10.3 VEGFA SMAD4 KRAS
23 pulmonary emphysema 10.3 VEGFA MMP2 CASP3
24 myh-associated polyposis 10.3 KRAS APC
25 osteonecrosis 10.3 VEGFA HIF1A DKK1
26 large intestine adenocarcinoma 10.3 SMAD4 KRAS FBXW7
27 cervical squamous cell carcinoma 10.3 VEGFA MMP2 KRAS HIF1A
28 arteriovenous malformation 10.3 VEGFA SMAD4 KRAS
29 pancreatic ductal carcinoma 10.3 VEGFA SMAD4 EGF
30 odontogenic myxoma 10.3 VEGFA MMP2
31 pre-malignant neoplasm 10.3 VEGFA KRAS EGF
32 rectum adenocarcinoma 10.3 LGR5 KRAS FBXW7
33 estrogen-receptor positive breast cancer 10.3 VEGFA HIF1A EGF
34 endometrial adenocarcinoma 10.3 VEGFA KRAS EGF
35 melanoma, uveal 10.3 VEGFA SMAD4 MMP2 HIF1A
36 serous cystadenocarcinoma 10.3 VEGFA MMP2 KRAS FBXW7
37 lymphangioma 10.3 VEGFA LGR5 KRAS APC
38 ovarian serous cystadenocarcinoma 10.3 VEGFA KRAS HIF1A FBXW7
39 retinal vascular disease 10.3 VEGFA HIF1A CASP3
40 thyroid gland follicular carcinoma 10.3 VEGFA MMP2 KRAS EGF
41 autonomic nervous system neoplasm 10.2 VEGFA HIF1A EGF CASP3
42 cell type benign neoplasm 10.2 VEGFA SMAD4 KRAS APC
43 malignant ovarian surface epithelial-stromal neoplasm 10.2 VEGFA KRAS CASP3 APC
44 spinal disease 10.2 VEGFA HIF1A EGF CASP3
45 hypotrichosis 1 10.2 VEGFA EGF CASP3
46 juvenile polyposis syndrome 10.2 SMAD4 SMAD3 APC
47 suppression of tumorigenicity 12 10.2 VEGFA SMAD4 EGF
48 malignant astrocytoma 10.2 VEGFA HIF1A EGF CASP3
49 malignant exocrine pancreas neoplasm 10.2 SMAD4 KRAS
50 cervical adenocarcinoma 10.2 KRAS EGF CASP3

Graphical network of the top 20 diseases related to Colon Adenoma:



Diseases related to Colon Adenoma

Symptoms & Phenotypes for Colon Adenoma

GenomeRNAi Phenotypes related to Colon Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.17 FBXW7 KRAS LGR5 MMP2 OGG1 RXRA

MGI Mouse Phenotypes related to Colon Adenoma:

46 (show all 24)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.5 APC CASP3 CTBP1 DKK1 EGF FBXW7
2 cellular MP:0005384 10.45 APC CASP3 DKK1 FBXW7 HDAC2 HIF1A
3 behavior/neurological MP:0005386 10.43 APC CASP3 HDAC2 HIF1A KRAS LGR5
4 cardiovascular system MP:0005385 10.42 APC CASP3 CTBP1 FBXW7 HDAC2 HIF1A
5 homeostasis/metabolism MP:0005376 10.42 APC CASP3 DKK1 FBXW7 HDAC2 HIF1A
6 craniofacial MP:0005382 10.41 APC CASP3 DKK1 FBXW7 HIF1A KRAS
7 immune system MP:0005387 10.41 APC CASP3 EGF FBXW7 HDAC2 HIF1A
8 digestive/alimentary MP:0005381 10.4 APC CASP3 EGF FBXW7 HDAC2 HIF1A
9 hematopoietic system MP:0005397 10.4 APC CASP3 FBXW7 HDAC2 HIF1A KRAS
10 endocrine/exocrine gland MP:0005379 10.39 APC CASP3 EGF FBXW7 HDAC2 HIF1A
11 mortality/aging MP:0010768 10.38 APC CASP3 CTBP1 DKK1 FBXW7 HDAC2
12 integument MP:0010771 10.34 APC CASP3 EGF FBXW7 HDAC2 HIF1A
13 embryo MP:0005380 10.28 APC CTBP1 DKK1 FBXW7 HIF1A KRAS
14 nervous system MP:0003631 10.28 APC CASP3 CTBP1 DKK1 FBXW7 HDAC2
15 neoplasm MP:0002006 10.25 APC FBXW7 HDAC2 HIF1A KRAS LGR5
16 limbs/digits/tail MP:0005371 10.21 APC DKK1 HDAC2 HIF1A KRAS RXRA
17 muscle MP:0005369 10.2 APC CASP3 CTBP1 HDAC2 HIF1A KRAS
18 liver/biliary system MP:0005370 10.15 APC FBXW7 HIF1A KRAS OGG1 RXRA
19 normal MP:0002873 10.11 APC EGF FBXW7 HDAC2 HIF1A KRAS
20 renal/urinary system MP:0005367 10.06 APC CASP3 DKK1 HIF1A KRAS LGR5
21 reproductive system MP:0005389 9.96 APC CASP3 EGF HDAC2 KRAS RXRA
22 respiratory system MP:0005388 9.85 CASP3 DKK1 FBXW7 HDAC2 HIF1A KRAS
23 skeleton MP:0005390 9.77 APC CASP3 CTBP1 DKK1 HDAC2 HIF1A
24 vision/eye MP:0005391 9.44 APC CASP3 DKK1 EGF FBXW7 HDAC2

Drugs & Therapeutics for Colon Adenoma

Drugs for Colon Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Scopolamine Approved, Investigational Phase 4 51-34-3, 6533-68-2 5184
2 Anticonvulsants Phase 4
3 Parasympatholytics Phase 4
4 Neurotransmitter Agents Phase 4
5 Gastrointestinal Agents Phase 4
6 Mydriatics Phase 4
7 Cholinergic Antagonists Phase 4
8 Anesthetics Phase 4
9 Muscarinic Antagonists Phase 4
10 Butylscopolammonium Bromide Phase 4
11 Cholinergic Agents Phase 4
12 Bromides Phase 4
13 Antiemetics Phase 4
14
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
15 Cola Phase 3
16 Anti-Inflammatory Agents Phase 3
17 Analgesics, Non-Narcotic Phase 3
18 Fibrinolytic Agents Phase 3
19 Anti-Inflammatory Agents, Non-Steroidal Phase 3
20 Analgesics Phase 3
21 Antirheumatic Agents Phase 3
22 Cyclooxygenase Inhibitors Phase 3
23 Platelet Aggregation Inhibitors Phase 3
24 Antipyretics Phase 3
25
Fosfomycin Approved Phase 2 23155-02-4 446987
26
Metronidazole Approved Phase 2 443-48-1 4173
27
nivolumab Approved Phase 2 946414-94-4
28 Anti-Infective Agents Phase 2
29 Antiparasitic Agents Phase 2
30 Antiprotozoal Agents Phase 2
31 Anti-Bacterial Agents Phase 2
32 Antineoplastic Agents, Immunological Phase 2
33
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
34 Pharmaceutical Solutions

Interventional clinical trials:

(show all 48)
# Name Status NCT ID Phase Drugs
1 Does Hyoscine N-butylbromide Administered During Colonoscopy Increase the Polyp Detection Rate? a Randomized, Single Center, Double Blind, Placebo-controlled Study Unknown status NCT01609855 Phase 4 Hyoscine Butyl Bromide 20mg/2 ml i.v.;Saline 2 ml i.v.
2 CSP #380 - Prospective Evaluation of Risk Factors for Large (> 1 CM) Colonic Adenomas in Asymptomatic Subjects Completed NCT00032344 Phase 3
3 Prospective Study on Aspirin Efficacy in Reducing Colorectal Adenoma Recurrence Terminated NCT00224679 Phase 3 Aspirin
4 Preoperative Endoscopic Treatment With Fosfomycin and Metronidazole in Patients With Right-sided Colon Cancer and Colon Adenoma: a Clinical Proof-of-concept Intervention Study MEFO Trial Recruiting NCT04312360 Phase 2 therapeutic endoscopy with metronidazole and fosfomycin disodium
5 A Phase II Study of PD-1 Inhibition for the Prevention of Colon Adenomas in Patients With Lynch Syndrome and a History of Partial Colectomy Active, not recruiting NCT03631641 Phase 2
6 Linked Color Imaging (LCI) and Magnifying Blue Laser Imaging (BLI) Versus Standard White Light for the Detection of Adenomas and Serrated Lesions in the Proximal Colon Unknown status NCT02724397
7 Effect of a Tracking Program on Colon Adenoma Surveillance and Adherence to Guideline Recommendations Unknown status NCT01713881
8 Usefulness of Fecal Calprotectin for Screening Colon Adenoma in Korean Population Unknown status NCT01719198
9 Impact of Diverticular Disease on the Detection of Colon Adenomas Unknown status NCT02057562
10 Computer-assisted Detection of Colonic Polyps Unknown status NCT02838888
11 NBI Versus White Light Endoscopy for Optical Characterization of Neoplastic Polyps in the Colorectum - the ADOPTION II Study Unknown status NCT03679429
12 The Impact of Split Dose of Low-volume Polyethylene Glycol on Adenoma Detection Rate: a Randomized, Investigator Blind, Controlled Trial Unknown status NCT02178033 Split dose low-volume PEG solution
13 A Prospective Study Stratifying Patients to Follow up Intervals Based on Risk of Recurrence Post Wide Field Colonic EMR Unknown status NCT02957058
14 Comparison of Colon Adenoma Detection Rate Using Two Distal Colonoscope Attachments Completed NCT02665741
15 Comparing Right Colon Adenoma and Hyperplastic Polyp Miss Rate in Colonoscopy Using Water Exchange and Carbon Dioxide Insufflation: A Prospective Randomized Controlled Trial Completed NCT03845933
16 Trainee Participation Increases Colon Adenoma Detection Rate: a Randomized Controlled Trial Completed NCT03908229
17 Single Center Prospective Evaluation Utilizing a Double Balloon Accessory Device to Facilitate Complex Endoscopic Polypectomy in Large Intestine Completed NCT03551379
18 Accuracy of the Optical Diagnosis of Small Colonic Polyps Using the Nice Classification Completed NCT02009774
19 Side Specific Withdrawal Times for Colonoscopy: Impact on Adenoma Detection in the Proximal and Distal Colon Completed NCT02819492
20 Effect of Video Monitor Size on Adenoma Detection Rate Completed NCT01952418
21 Linked Color Imaging (LCI) Versus Standard White-light Colonoscopy for Colorectal Adenoma Detection: a Multicenter, Randomized, Trial Completed NCT03690297
22 Impact of Second Forward View Examination of Proximal Colon on Adenoma Detection Rate: A Randomized Clinical Trial Completed NCT03619122
23 Artificial Intelligence-Assisted Real-time Detection of Missed Lesions During Colonoscopy: A Prospective Study Completed NCT04227795
24 Tandem Colonoscopy Study of Linked Color Imaging Versus Narrow Band Imaging on Colorectal Adenoma Detection: A Prospective, Randomized Study Completed NCT03336359
25 Soft Coagulation for the Prevention of Adenoma Recurrence After Endoscopic Mucosal Resection (EMR) of Large Sessile Colonic Polyps: A Multicentre, Randomized Trial. Completed NCT01789749
26 A Randomized Comparison Between White Light Endoscopy (WLE) and Bright Narrow Band Imaging (B-NBI) in the Diagnosis of Colonic Adenomas in Asymptomatic Subjects Undergoing Screening Colonoscopy Completed NCT01422577
27 The Effect of Taking Break During Colonoscopy Session on Adenoma Detection, a Prospective, Randomized Control Study Completed NCT01989650
28 High Definition Endoscopy and Virtual Chromoendoscopy Versus Standard Resolution Endoscopy in Detection of Colon Polyps Completed NCT03243669
29 A Prospective Randomized Study of Colonoscopy Using Blue Laser Imaging and White Light Imaging in the Detection and Differentiation of Colonic Polyps Completed NCT03421600
30 Water Exchange Colonoscopy Decreased Adenoma Miss Rates in the Right and Proximal Colon: An Observational Study Using A Tandem Colonoscopy Approach Completed NCT03832322
31 Endocuff-assisted Colonoscopy vs Standard Colonoscopy on Adenoma Detection Rate: A Comparative Prospective Study in Common Practice Completed NCT03344055
32 Dynamic Position Change in Colonic Adenoma Detection: a Prospective, Randomized, Multicenter Study Completed NCT01366079
33 A Randomised Comparison Between White Light Endoscopy (WLE) and Bright Narrow Band Imaging (B-NBI) in the Diagnosis of Colonic Adenomas in Asymptomatic Subjects Undergoing Screening Colonoscopy. Recruiting NCT01737567
34 Comparing Right Colon Adenoma and Hyperplastic Polyp Miss Rates in Colonoscopy Using Water Exchange and CO2 Insufflation: A Multicenter Randomized Tandem Study Recruiting NCT04124393
35 The Australian Colonic Large Sessile Lesion Endoscopic Resection Study Recruiting NCT03471793
36 Correlation Between Surrogate Quality Indicators for Adenoma Detection Rate (ADR) and Adenoma Miss Rate (AMR) in Qualified Colonoscopy: CORE Study Recruiting NCT03919487
37 Blue Laser Imaging Versus Narrow Band Imaging Versus White Light Imaging for Detection of Adenoma in the Proximal Colon: A Prospective Randomized Study Recruiting NCT03696992
38 Comparative Analysis of the Incremental Benefit of Chromoendoscopy in Addition to High Definition White Light (HD-WL)and Narrow Band Imaging (NBI) for the Prediction of Submucosal Invasive Cancer Within Laterally Spreading Lesions (LSLs) and in Determining the Presence of Residual or Recurrent Adenoma at a Post Endoscopic Resection Scar Recruiting NCT03506321
39 Evaluation of Endorings-2-assisted Colonoscopy: a New Accessory for Improvement of Adenoma Detection Rate? Recruiting NCT03385434
40 A Randomized Controlled Trial Comparing Right vs Left Lateral Decubitus Positioning on Outcomes in Colonoscopy Recruiting NCT03355495
41 Endoscopic Submucosal Dissection (ESD) Versus Endoscopic Mucosal Resection (EMR) for Large Non Pedunculated Colonic Adenomas: a Randomized Comparative Trial Recruiting NCT03962868
42 Multi-center Prospective Registry Study Utilizing a Double Balloon Accessory Device to Facilitate Endoscopic Polypectomy in Large Intestine. Active, not recruiting NCT03942965
43 Can Pan-Colonic Chromoendoscopy (PCC) Improve Adenoma Detection Rate in FIT-Positive-Patients: A Randomized Study Active, not recruiting NCT04512612
44 Randomized Controlled Trial of Comparison Between Surveillance Intervals After Excision of Colonic Adenomas Active, not recruiting NCT02319928
45 Risk Factors of Inadequate Bowel Cleansing in Inpatients: a Predictive Score Not yet recruiting NCT03902561
46 Artificial Intelligence-assisted Colonoscopy Versus Conventional Colonoscopy for Missed Lesions in the Proximal Colon: A Prospective Multi-center Randomized Study in Asia Not yet recruiting NCT04294355
47 Risk Factors of Inadequate Bowel Cleansing in Colon Capsule Endoscopy Not yet recruiting NCT03933371
48 The Utility of Time Segmental Withdrawal During Screening Colonoscopy for Increasing Adenoma Detection Rate. A Randomized Controlled Clinical Trial. Terminated NCT02538406

Search NIH Clinical Center for Colon Adenoma

Genetic Tests for Colon Adenoma

Anatomical Context for Colon Adenoma

MalaCards organs/tissues related to Colon Adenoma:

40
Colon, Breast, Lymph Node, Liver, Pancreas, Skin, Endothelial

Publications for Colon Adenoma

Articles related to Colon Adenoma:

(show top 50) (show all 365)
# Title Authors PMID Year
1
Modular Reorganization of Signaling Networks during the Development of Colon Adenoma and Carcinoma. 61
33562960 2021
2
Chemopreventive effects of raw and roasted oat flakes after in vitro fermentation with human faecal microbiota. 61
32482126 2021
3
Dairy intake during adolescence and risk of colorectal adenoma later in life. 61
33398066 2021
4
Thermal Processing has no Impact on Chemopreventive Effects of Oat and Barley Kernels in LT97 Colon Adenoma Cells. 61
33305613 2020
5
Oral indigo carmine for the detection of colon adenoma. 61
33378628 2020
6
Alteration of fecal tryptophan metabolism correlates with shifted microbiota and may be involved in pathogenesis of colorectal cancer. 61
33362375 2020
7
Epigenetic Inactivation of α-Internexin Accelerates Microtubule Polymerization in Colorectal Cancer. 61
33051252 2020
8
Impact of fellow participation on colon adenoma detection rates: a multicenter randomized trial. 61
32433915 2020
9
Impact of EndoRings on colon adenoma detection rate: A meta-analysis of randomized trials. 61
33140884 2020
10
Effects of Supplemental Calcium and Vitamin D on Circulating Biomarkers of Gut Barrier Function in Patients with Colon Adenoma: A Randomized Clinical Trial. 61
33229339 2020
11
Comparison of Right Colon Adenoma Miss Rates Between Water Exchange and Carbon Dioxide Insufflation: A Prospective Randomized Controlled Trial. 61
33074950 2020
12
Endocuff-assisted versus Cap-assisted Colonoscopy in Increasing Adenoma Detection Rate. A Meta-analysis. 61
32830810 2020
13
The behavior of MMP-2, MMP-7, MMP-9 and their inhibitors TIMP-1, TIMP-2 in adenoma-colorectal cancer sequence. 61
32961536 2020
14
mSphere of Influence: Organoids and Single-Cell Sequencing, a Powerful Combination To Uncover Epithelial and Immune Cell Interactions in the Human Gut Environment. 61
32727865 2020
15
Radiofrequency ablation as an adjunct for recurrent colon adenoma. 61
31733199 2020
16
Cap-Assisted Chromoendoscopy Using a Mounted Cap Versus Standard Colonoscopy for Adenoma Detection. 61
31972618 2020
17
Study on chemopreventive effects of raw and roasted β-glucan-rich waxy winter barley using an in vitro human colon digestion model. 61
32176229 2020
18
Dose-response meta-analysis of coffee consumption and risk of colorectal adenoma. 61
31308476 2020
19
Relationship between serum gamma-glutamyl transferase level and colorectal adenoma. 61
33048943 2020
20
Senescent Cell-Secreted Netrin-1 Modulates Aging-Related Disorders by Recruiting Sympathetic Fibers. 61
33390926 2020
21
A circulating extracellular vesicles-based novel screening tool for colorectal cancer revealed by shotgun and data-independent acquisition mass spectrometry. 61
32363013 2020
22
Phospholipid profiling enables to discriminate tumor- and non-tumor-derived human colon epithelial cells: Phospholipidome similarities and differences in colon cancer cell lines and in patient-derived cell samples. 61
31999740 2020
23
Molecular Alterations in Circulating Cell-Free DNA in Patients with Colorectal Adenoma or Carcinoma. 61
32636678 2020
24
Comparison of application value between conventional air insufflation and water infusion in colonoscopy. 61
33042339 2020
25
Integrated Imaging Methodology Detects Claudin-1 Expression in Premalignant Nonpolypoid and Polypoid Colonic Epithelium in Mice. 61
31922993 2020
26
Comparison of colon adenoma detection rates using cap-assisted and Endocuff-assisted colonoscopy: a randomized controlled trial. 61
31788539 2019
27
Prognostic Value of TWIST1 and EZH2 Expression in Colon Cancer. 61
31823218 2019
28
Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15. 61
31389184 2019
29
Intermittent Dosing Regimens of Aspirin and Naproxen Inhibit Azoxymethane-Induced Colon Adenoma Progression to Adenocarcinoma and Invasive Carcinoma. 61
31530543 2019
30
Compared Abilities of Endoscopic Techniques to Increase Colon Adenoma Detection Rates: A Network Meta-analysis. 61
30529731 2019
31
Microbiota alterations after colon adenoma resection. 61
31726487 2019
32
Obesity, diabetes and the risk of colorectal adenoma and cancer. 61
31664994 2019
33
Randomized control trial of adenoma detection rate in Endocuff-assisted colonoscopy versus transparent hood-assisted colonoscopy. 61
31254485 2019
34
Meta-Analysis of Cancer Triploidy: Rearrangements of Genome Complements in Male Human Tumors Are Characterized by XXY Karyotypes. 61
31412657 2019
35
Antioxidative, Anti-Inflammatory, and Anticancer Effects of Purified Flavonol Glycosides and Aglycones in Green Tea. 61
31387266 2019
36
G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma. 61
29971639 2019
37
[Comparison of endoscopic features between colorectal sessile serrated adenoma/polyp with or without cytologic dysplasia and hyperplastic polyp]. 61
31434395 2019
38
Patients with breast cancer may be at higher risk of colorectal neoplasia. 61
31263363 2019
39
Metaproteomics of fecal samples of Crohn's disease and Ulcerative Colitis. 61
31009805 2019
40
The benefit of adding oral simethicone in bowel preparation regimen for the detection of colon adenoma: A systematic review and meta-analysis. 61
30311262 2019
41
Colon adenoma and adenocarcinoma with clear cell components - two case reports. 61
31077226 2019
42
Synchronous Duodenal Adenocarcinoma and Colon Adenoma Following with Lynch Syndrome Requiring Pancreaticoduodenectomy and Completion Total Colectomy with Ileorectal Anastomosis. 61
32432215 2019
43
Tumor response to irinotecan is associated with CYP3A5 expression in colorectal cancer. 61
30881507 2019
44
Redox, immune and genetic biomarker system for personalized treatments in colorectal cancer. 61
30788039 2019
45
Interleukin-37 Inhibits Colon Carcinogensis During Chronic Colitis. 61
31781119 2019
46
The ASAMET trial: a randomized, phase II, double-blind, placebo-controlled, multicenter, 2 × 2 factorial biomarker study of tertiary prevention with low-dose aspirin and metformin in stage I-III colorectal cancer patients. 61
30514262 2018
47
ACTL6A expression promotes invasion, metastasis and epithelial mesenchymal transition of colon cancer. 61
30348114 2018
48
Clonal Structures of Regionally Synchronous Gastric Adenomas and Carcinomas. 61
29945994 2018
49
Clinical Value of CXCL5 for Determining of Colorectal Cancer 61
30255816 2018
50
Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors. 61
29524208 2018

Variations for Colon Adenoma

Expression for Colon Adenoma

Search GEO for disease gene expression data for Colon Adenoma.

Pathways for Colon Adenoma

Pathways related to Colon Adenoma according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.09 VEGFA SMAD4 SMAD3 RXRA LGR5 KRAS
2
Show member pathways
13.72 SMAD4 SMAD3 KRAS HDAC2 FBXW7 EGF
3
Show member pathways
13.49 VEGFA SMAD4 SMAD3 RXRA MMP2 KRAS
4
Show member pathways
13.09 VDR SMAD4 SMAD3 RXRA KRAS EGF
5
Show member pathways
13.05 SMAD4 SMAD3 RXRA KRAS EGF CASP3
6
Show member pathways
12.96 VEGFA RXRA KRAS HDAC2 EGF CASP3
7
Show member pathways
12.74 SMAD4 SMAD3 RXRA KRAS EGF APC
8
Show member pathways
12.6 VEGFA SMAD4 SMAD3 RXRA KRAS HDAC2
9 12.52 VEGFA KRAS HDAC2 CASP3 APC
10
Show member pathways
12.52 SMAD3 HIF1A HDAC2 H4-16 FBXW7 CTBP1
11
Show member pathways
12.45 SMAD4 SMAD3 DKK1 APC
12
Show member pathways
12.45 VEGFA SMAD4 SMAD3 KRAS EGF CASP3
13 12.36 SMAD4 SMAD3 HDAC2 APC
14
Show member pathways
12.31 SMAD3 MMP2 EGF APC
15 12.29 KRAS HDAC2 H4-16 CASP3
16
Show member pathways
12.29 VEGFA KRAS HIF1A CASP3
17 12.29 VEGFA MMP2 KRAS HIF1A CASP3
18 12.23 SMAD4 SMAD3 DKK1 APC
19
Show member pathways
12.19 RXRA HDAC2 H4-16 FBXW7
20 12.14 VEGFA SMAD4 KRAS CASP3
21 12.13 VEGFA SMAD4 SMAD3 RXRA MMP2 KRAS
22 12.09 SMAD4 SMAD3 KRAS APC
23
Show member pathways
12.07 SMAD4 SMAD3 KRAS EGF
24 12.05 VEGFA LGR5 EGF DKK1
25 12.05 SMAD4 SMAD3 LGR5 DKK1 CTBP1 APC
26 12.01 VDR MMP2 HDAC2 DKK1 APC
27 12 RXRA KRAS HIF1A HDAC2
28 11.96 SMAD4 SMAD3 KRAS APC
29 11.87 SMAD4 SMAD3 KRAS
30 11.78 VEGFA SMAD4 SMAD3 MMP2 KRAS EGF
31 11.75 MMP2 HDAC2 DKK1 CTBP1 APC
32 11.73 VEGFA MMP2 KRAS EGF
33 11.73 VEGFA SMAD4 SMAD3 MMP2 KRAS CASP3
34 11.72 VDR SMAD4 SMAD3 HDAC2 CTBP1
35
Show member pathways
11.71 VEGFA HIF1A CTBP1
36 11.69 SMAD3 HDAC2 EGF
37 11.68 SMAD3 MMP2 HIF1A CASP3
38 11.66 VEGFA SMAD4 SMAD3 HIF1A
39 11.63 HDAC2 FBXW7 CTBP1
40 11.61 SMAD4 SMAD3 EGF
41 11.61 VEGFA SMAD4 SMAD3 MMP2 HDAC2 CTBP1
42
Show member pathways
11.6 SMAD4 SMAD3 MMP2 EGF
43 11.52 VEGFA EGF DKK1
44 11.49 DKK1 CTBP1 APC
45 11.48 VDR SMAD3 RXRA
46 11.45 VEGFA KRAS EGF
47 11.43 VEGFA SMAD4 SMAD3 HIF1A CASP3
48 11.34 RXRA HDAC2 CASP3
49 11.26 SMAD4 SMAD3 KRAS APC
50 10.86 VDR RXRA

GO Terms for Colon Adenoma

Cellular components related to Colon Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.25 VEGFA VDR SMAD4 SMAD3 RXRA MMP2
2 nucleus GO:0005634 10.21 VDR SPN SMAD4 SMAD3 RXRA OGG1
3 nucleoplasm GO:0005654 9.77 VDR SMAD4 SMAD3 RXRA OGG1 LGR5
4 protein-containing complex GO:0032991 9.63 SMAD3 OGG1 HIF1A HDAC2 H4-16 FBXW7
5 heteromeric SMAD protein complex GO:0071144 9.32 SMAD4 SMAD3
6 SMAD protein complex GO:0071141 9.26 SMAD4 SMAD3
7 RNA polymerase II transcription factor complex GO:0090575 8.92 VDR SMAD4 RXRA HIF1A

Biological processes related to Colon Adenoma according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.11 VEGFA VDR SMAD4 SMAD3 RXRA HIF1A
2 cell differentiation GO:0030154 10.02 VEGFA VDR SMAD4 SMAD3 RXRA HIF1A
3 positive regulation of transcription, DNA-templated GO:0045893 10.01 SMAD4 SMAD3 RXRA HIF1A HDAC2 EGF
4 negative regulation of cell proliferation GO:0008285 9.97 VDR SMAD4 SMAD3 CTBP1 APC
5 protein deubiquitination GO:0016579 9.93 SMAD4 SMAD3 HIF1A APC
6 negative regulation of transcription by RNA polymerase II GO:0000122 9.92 VEGFA VDR SMAD4 SMAD3 RXRA HDAC2
7 positive regulation of cell migration GO:0030335 9.91 VEGFA SMAD3 EGF APC
8 angiogenesis GO:0001525 9.9 VEGFA MMP2 HIF1A EGF
9 negative regulation of apoptotic process GO:0043066 9.8 VEGFA SMAD3 OGG1 HIF1A HDAC2 DKK1
10 positive regulation of endothelial cell proliferation GO:0001938 9.77 VEGFA HIF1A EGF
11 cytokine-mediated signaling pathway GO:0019221 9.77 VEGFA MMP2 KRAS HIF1A CASP3
12 positive regulation of MAP kinase activity GO:0043406 9.72 VEGFA KRAS EGF
13 positive regulation of gene expression GO:0010628 9.7 VEGFA VDR SMAD3 KRAS HIF1A EGF
14 positive regulation of epithelial to mesenchymal transition GO:0010718 9.69 SMAD4 SMAD3 HDAC2
15 lactation GO:0007595 9.67 VEGFA VDR HIF1A
16 positive regulation of signaling receptor activity GO:2000273 9.62 HIF1A HDAC2
17 positive regulation of epidermal growth factor-activated receptor activity GO:0045741 9.62 FBXW7 EGF
18 positive regulation of positive chemotaxis GO:0050927 9.61 VEGFA SMAD3
19 positive regulation of protein localization to early endosome GO:1902966 9.58 VEGFA EGF
20 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.58 SMAD4 SMAD3 HIF1A
21 SMAD protein complex assembly GO:0007183 9.56 SMAD4 SMAD3
22 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.52 VEGFA HIF1A
23 positive regulation of epithelial tube formation GO:1905278 9.46 VEGFA EGF
24 regulation of binding GO:0051098 9.43 SMAD4 SMAD3
25 regulation of transforming growth factor beta2 production GO:0032909 9.13 SMAD4 SMAD3 HIF1A
26 response to hypoxia GO:0001666 9.1 VEGFA SMAD4 SMAD3 MMP2 HIF1A CASP3

Molecular functions related to Colon Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.13 VEGFA VDR SPN SMAD4 SMAD3 RXRA
2 I-SMAD binding GO:0070411 9.26 SMAD4 SMAD3
3 sequence-specific DNA binding GO:0043565 9.1 VDR SMAD4 SMAD3 RXRA HIF1A HDAC2
4 vitamin D response element binding GO:0070644 8.96 VDR RXRA

Sources for Colon Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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