MCID: CLN044
MIFTS: 43

Colon Adenoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Colon Adenoma

MalaCards integrated aliases for Colon Adenoma:

Name: Colon Adenoma 12 15
Adenomatous Polyp of Colon 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050912
UMLS 74 C0850572

Summaries for Colon Adenoma

Disease Ontology : 12 A colonic benign neoplasm that has material basis in epithelial tissue with glandular origin.

MalaCards based summary : Colon Adenoma, also known as adenomatous polyp of colon, is related to colorectal cancer and colorectal adenoma. An important gene associated with Colon Adenoma is APC (APC Regulator Of WNT Signaling Pathway), and among its related pathways/superpathways are Nanog in Mammalian ESC Pluripotency and Endometrial cancer. The drugs Scopolamine and Simethicone have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and lung, and related phenotypes are craniofacial and digestive/alimentary

Related Diseases for Colon Adenoma

Diseases related to Colon Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 colorectal cancer 30.9 APC CASP3 KRAS OGG1 UGT1A1 VDR
2 colorectal adenoma 29.8 APC KRAS VDR
3 lynch syndrome 29.7 APC KRAS OGG1
4 colon adenocarcinoma 29.2 APC CASP3 KRAS
5 familial adenomatous polyposis 4 11.3
6 polyposis syndrome, hereditary mixed, 1 11.2
7 polyposis syndrome, hereditary mixed, 2 11.2
8 familial adenomatous polyposis 3 11.2
9 adenoma 10.8
10 adenocarcinoma 10.4
11 attenuated familial adenomatous polyposis 10.3 APC OGG1
12 periampullary adenoma 10.3 APC KRAS
13 hyperplastic polyposis syndrome 10.3 APC KRAS
14 mutyh-associated polyposis 10.3 APC KRAS
15 colonic benign neoplasm 10.1 KRAS LGR5
16 barrett's adenocarcinoma 10.1 GSTT2 KRAS OGG1
17 intestinal benign neoplasm 10.1 APC KRAS LGR5
18 familial adenomatous polyposis 10.1
19 renal pelvis carcinoma 10.0 MACC1 VEGFA
20 colitis 10.0
21 rosacea 9.9 VDR VEGFA
22 liver angiosarcoma 9.9 KRAS UGT1A1
23 ulcerative colitis 9.9
24 gangliocytoma 9.9
25 ganglioneuroma 9.9
26 malakoplakia 9.9
27 primary effusion lymphoma 9.8 CASP3 VEGFA
28 respiratory system cancer 9.8 CASP3 KRAS VEGFA
29 gastrointestinal system cancer 9.8 CASP3 KRAS VEGFA
30 respiratory system disease 9.8 CASP3 KRAS VEGFA
31 endocrine gland cancer 9.8 CASP3 KRAS VEGFA
32 gastrointestinal system disease 9.8 CASP3 KRAS VEGFA
33 pancreas adenocarcinoma 9.8 CASP3 KRAS VEGFA
34 diabetes mellitus, noninsulin-dependent 9.7
35 polyposis, skin pigmentation, alopecia, and fingernail changes 9.7
36 retinoblastoma 9.7
37 chondrosarcoma 9.7
38 cystic fibrosis 9.7
39 myasthenia gravis 9.7
40 insulin-like growth factor i 9.7
41 gallbladder disease 1 9.7
42 gastric cancer 9.7
43 autoimmune pancreatitis 9.7
44 colorectal adenocarcinoma 9.7
45 janus kinase-3 deficiency 9.7
46 glucose intolerance 9.7
47 sarcoma 9.7
48 diarrhea 9.7
49 acromegaly 9.7
50 uremia 9.7

Graphical network of the top 20 diseases related to Colon Adenoma:



Diseases related to Colon Adenoma

Symptoms & Phenotypes for Colon Adenoma

MGI Mouse Phenotypes related to Colon Adenoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.85 APC CASP3 KRAS LGR5 VDR VEGFA
2 digestive/alimentary MP:0005381 9.8 APC CASP3 KRAS LGR5 VDR VEGFA
3 muscle MP:0005369 9.73 APC CASP3 CTBP1 KRAS VDR VEGFA
4 nervous system MP:0003631 9.56 APC CASP3 CTBP1 KLK6 KRAS OGG1
5 neoplasm MP:0002006 9.55 APC KRAS LGR5 OGG1 VEGFA
6 renal/urinary system MP:0005367 9.1 APC CASP3 KRAS LGR5 VDR VEGFA

Drugs & Therapeutics for Colon Adenoma

Drugs for Colon Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 111)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Scopolamine Approved, Investigational Phase 4 51-34-3, 6533-68-2 5184
2
Simethicone Approved Phase 4,Not Applicable 8050-81-5
3
Sodium sulfate Approved, Vet_approved Phase 4 7757-82-6
4
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Not Applicable 50-81-7 54670067 5785
5 Butylscopolammonium Bromide Phase 4
6 Cholinergic Antagonists Phase 4
7 Anesthetics Phase 4,Not Applicable
8 Gastrointestinal Agents Phase 4,Phase 3,Phase 1
9 Muscarinic Antagonists Phase 4
10 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
11 Autonomic Agents Phase 4
12 Antiemetics Phase 4
13 Adjuvants, Anesthesia Phase 4
14 Bromides Phase 4
15 Parasympatholytics Phase 4
16 Mydriatics Phase 4
17 Cholinergic Agents Phase 4
18 Neurotransmitter Agents Phase 4
19 Anticonvulsants Phase 4
20 Pharmaceutical Solutions Phase 4,Phase 3,Not Applicable
21 Cola Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Dermatologic Agents Phase 4,Not Applicable
23 Emollients Phase 4,Not Applicable
24 Laxatives Phase 4,Phase 3,Not Applicable
25 Cathartics Phase 4,Phase 3,Not Applicable
26 Polyethylene glycol 3350 Phase 4
27
Bisacodyl Approved Phase 3,Not Applicable 603-50-9
28
Sodium Citrate Approved, Investigational Phase 3 68-04-2
29
Magnesium citrate Approved Phase 3 3344-18-1
30
carbamide peroxide Approved Phase 2, Phase 3 124-43-6
31
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
32
Sulindac Approved, Investigational Phase 3 38194-50-2 1548887 5352
33
Celecoxib Approved, Investigational Phase 3 169590-42-5 2662
34
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
35
Calcium Approved, Nutraceutical Phase 3,Phase 1 7440-70-2 271
36
Vitamin D3 Approved, Nutraceutical Phase 3 67-97-0 5280795 6221
37
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
38
Ergocalciferol Approved, Nutraceutical Phase 3 50-14-6 5280793
39
Ornithine Approved, Nutraceutical Phase 3 70-26-8, 3184-13-2 6262
40 Protective Agents Phase 3,Not Applicable
41 Trace Elements Phase 3,Not Applicable
42 Nutrients Phase 3,Not Applicable
43 Antioxidants Phase 3,Not Applicable
44 Vitamins Phase 3,Not Applicable
45 Micronutrients Phase 3,Not Applicable
46 Citrate Phase 3
47 Picosulfate sodium Phase 3
48 Anticoagulants Phase 3
49 Calcium, Dietary Phase 3,Phase 1
50 Chelating Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 113)
# Name Status NCT ID Phase Drugs
1 Does the Hyoscine N-Butylbromide Administered During Colonoscopy Increase the Adenoma Detection Rate? Unknown status NCT01609855 Phase 4 Hyoscine Butyl Bromide 20mg/2 ml i.v.;Saline 2 ml i.v.
2 Effect of Simethicone on Screening Colonoscopy Completed NCT03119168 Phase 4 Simethicone Solution
3 Evaluation of Colonoscopy With a Specific Device for the Detection of Adenomas Recruiting NCT03436004 Phase 4
4 Study Comparing the Bowel Cleansing Efficacy of PLENVU® Versus SELG-ESSE® Using a 2-Day Split Dosing Regimen. Active, not recruiting NCT03742232 Phase 4 PEG3350;Macrogol 4000
5 Comparison of Low Volume PEG-Asc and Lower Volume PEG-Asc With Bisacodyl Completed NCT02980562 Phase 3 Polyethylene Glycols;Bisacodyl
6 A Randomized Prospective Trial Comparing Low-volume Bowel Preparation Methods Completed NCT02250196 Phase 3 PEG-Asc;SPMC 2
7 A Randomized Prospective Trial Comparing Polyethylene Glycol and Sodium Picosulphate With Magnesium Citrate Completed NCT01778192 Phase 3 Polyethylene glycol;Polyethylene glycol;Sodium picosulphate with magnesium citrate;Sodium picosulphate with magnesium citrate
8 Long-term Follow-up Study Designed to Evaluate the Relative Risk of Two Colonoscopy Schedules for Patients With Small Polyps Completed NCT00032344 Phase 3
9 Effect of 2 Doses of EPA on Apoptosis and Cell Proliferation on Colon Mucosa Completed NCT00432913 Phase 2, Phase 3 Eicosapentaenoic Acid (EPA)
10 Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women Completed NCT01052051 Phase 3
11 Evaluation of Computer-assisted, Non-cathartic CT Colonography Completed NCT01200303 Phase 2, Phase 3
12 S0820, Adenoma and Second Primary Prevention Trial Recruiting NCT01349881 Phase 3 Eflornithine placebo & sulindac placebo;eflornithine & sulindac placebo;Eflornithine placebo & sulindac;Eflornithine plus sulindac
13 APACC Study:Prospective Study on Aspirin Efficacy in Reducing Colorectal Adenoma Recurrence Terminated NCT00224679 Phase 3 Aspirin
14 Rosuvastatin in Treating Patients With Stage I or Stage II Colon Cancer That Was Removed By Surgery Terminated NCT01011478 Phase 3 rosuvastatin
15 Celecoxib in Preventing Polyps in Patients Who Have Undergone Surgery for Stage I Colon Cancer Terminated NCT00087256 Phase 3 Celecoxib
16 Minimizing the Risk of Metachronous Adenomas of the Colorectum With Green Tea Extract -MIRACLE- Unknown status NCT01360320 Phase 2
17 Detection and Classification of Colon Polyps Completed NCT00825292 Phase 2
18 Nivolumab in Preventing Colon Adenomas in Participants With Lynch Syndrome and a History of Partial Colectomy Recruiting NCT03631641 Phase 2
19 Study of the Immune Response of MUC1 (Mucin1) Peptide Vaccine for Non-small Cell Lung Cancer Recruiting NCT01720836 Phase 1, Phase 2
20 Study of Performance of Confocal Endomicroscope With Fluorescein Imaging Agent in the Colon Recruiting NCT03220711 Phase 1 Fluorescein
21 Aquamin and Prevention of Colon Cancer Active, not recruiting NCT02647671 Phase 1 Aquamin®;Calcium Carbonate;Placebo
22 Study of QRH-882260 Heptapeptide Application in the Colon Terminated NCT03148119 Phase 1 QRH-882260 Heptapeptide
23 Usefulness of Calprotectin for Colon Adenoma Screening Unknown status NCT01719198
24 Impact of Diverticular Disease on the Detection of Colon Adenomas Unknown status NCT02057562
25 Effect of a Tracking Program on Colon Adenoma Surveillance and Adherence to Guideline Recommendations Unknown status NCT01713881
26 Computer-assisted Detection of Colonic Polyps Unknown status NCT02838888
27 The Impact of Split Dose of Low-volume Polyethylene Glycol on Adenoma Detection Rate Unknown status NCT02178033 Not Applicable Split dose low-volume PEG solution
28 Linked Color Imaging/Magnifying Blue Laser Imaging vs. White Light for Adenomas and Serrated Lesions in Proximal Colon Unknown status NCT02724397 Not Applicable
29 Endoscopic Full-thickness REsection of Residual Colorectal Lesions - The FiRE Study Unknown status NCT02353533 Not Applicable
30 Feasibility, Safety and Outcome of Transrectal Hybrid-NOTES Anterior Resection Unknown status NCT01992406
31 Diagnosis of Colonic Adenomas by Bright Narrow Band Imaging (B-NBI) Completed NCT01422577 Not Applicable
32 Comparison of Colon Adenoma Detection Rate Using Two Distal Colonoscope Attachments Completed NCT02665741 Not Applicable
33 Impacts of Inspection During Instrument Insertion on Colonoscopy Quality Completed NCT03444090 Not Applicable
34 Dynamic Position Change in Colonic Adenoma Detection Completed NCT01366079 Not Applicable
35 Linked Color Imaging Versus Narrow Band Imaging for Colorectal Adenoma Detection Completed NCT03336359 Not Applicable
36 Side Specific Withdrawal Times for Colonoscopy: Impact on Adenoma Detection in the Proximal and Distal Colon Completed NCT02819492
37 Effect of Video Monitor Size on Adenoma Detection Rate Completed NCT01952418 Not Applicable
38 A Follow-up Colonoscopy Examination in Patients Who Had Previously Undergone Screening Colonoscopy Completed NCT00280332
39 Physical Activity Intervention With People at Increased Risk of Developing Colon Cancer Completed NCT02724306 Not Applicable
40 High Definition Endoscopy and Virtual Chromoendoscopy Versus Standard Resolution Endoscopy in Detection of Colon Polyps Completed NCT03243669 Not Applicable
41 Plasma ctDNA in Patients Undergoing Diagnostic Colonoscopy Completed NCT02665299
42 The Effect of Taking Break During Colonoscopy Session on Adenoma Detection, a Prospective, Randomized Control Study Completed NCT01989650 Not Applicable
43 Soft Coagulation for the Prevention of Adenoma Recurrence Completed NCT01789749 Not Applicable
44 CRC Screening for High Risk Population in HK Completed NCT03597204 Not Applicable
45 Narrow Band Imaging for Diagnosis of Proximal Serrated Polyps Completed NCT01725321
46 Adenoma Miss Rate With Water Exchange vs Carbon Dioxide Colonoscopy Completed NCT03832322
47 Accuracy of the Optical Diagnosis of Small Colonic Polyps Using the Nice Classification Completed NCT02009774
48 Phytoestrogens and Colonic Adenomatous Polyps Completed NCT03417258
49 Detection in Tandem Endocuff Cap Trial Completed NCT03254498 Not Applicable
50 Water-aided Colonoscopy vs Air Insufflation Colonoscopy in Colorectal Cancer Screening Completed NCT02041507 Not Applicable

Search NIH Clinical Center for Colon Adenoma

Genetic Tests for Colon Adenoma

Anatomical Context for Colon Adenoma

MalaCards organs/tissues related to Colon Adenoma:

42
Colon, Testes, Lung, Liver, Bone, Pancreas, Thyroid

Publications for Colon Adenoma

Articles related to Colon Adenoma:

(show top 50) (show all 82)
# Title Authors Year
1
Colon adenoma and adenocarcinoma with clear cell components - two case reports. ( 31077226 )
2019
2
The benefit of adding oral simethicone in bowel preparation regimen for the detection of colon adenoma: A systematic review and meta-analysis. ( 30311262 )
2019
3
Compared Abilities of Endoscopic Techniques to Increase Colon Adenoma Detection Rates: A Network Meta-analysis. ( 30529731 )
2018
4
The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma. ( 29422500 )
2018
5
Identification, isolation and characterization of human LGR5-positive colon adenoma cells. ( 29467240 )
2018
6
Colon adenoma with 2 too-long stalks (with video). ( 29223383 )
2018
7
Chemopreventive Potential of In Vitro Fermented Raw and Roasted Hazelnuts in LT97 Colon Adenoma Cells. ( 29277760 )
2018
8
Influence of roasting on the chemopreventive potential of in vitro fermented almonds in LT97 colon adenoma cells. ( 28583046 )
2018
9
Altered microRNA profiles during early colon adenoma progression in a porcine model of familial adenomatous polyposis. ( 29221194 )
2017
10
In vitro-fermented raw and roasted walnuts induce expression of CAT and GSTT2 genes, growth inhibition, and apoptosis in LT97 colon adenoma cells. ( 29241580 )
2017
11
Chemopreventive potential of in vitro fermented nuts in LT97 colon adenoma and primary epithelial colon cells. ( 27996158 )
2017
12
Colon adenoma features and their impact on risk of future advanced adenomas and colorectal cancer. ( 28035253 )
2016
13
Colon Adenoma Implicating Myasthenia Gravis: A Case Report of a Patient with Postcolectomy Complications. ( 27610255 )
2016
14
Effect of Insulin and Metformin Combination Treatment on Colon Adenoma and Advanced Adenoma Among DM II. ( 27256336 )
2016
15
Increased MACC1 levels in tissues and blood identify colon adenoma patients at high risk. ( 27439755 )
2016
16
Effect of a Polyp Tracking and Notification Program on Colon Adenoma Surveillance and Compliance to Guideline Recommendations. ( 27483534 )
2016
17
Insertion water exchange increases right colon adenoma and hyperplastic polyp detection rates during withdrawal. ( 27017108 )
2016
18
Cell-surface markers for colon adenoma and adenocarcinoma. ( 26894861 )
2016
19
Mucins and associated glycan signatures in colon adenoma-carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer. ( 26898938 )
2016
20
Low Serum Vitamin D: A Surrogate Marker for Advanced Colon Adenoma? ( 26905602 )
2016
21
Circulating Biomarkers of Gut Barrier Function: Correlates and Nonresponse to Calcium Supplementation among Colon Adenoma Patients. ( 26677212 )
2016
22
Elevated Coexpression of KITENIN and the ErbB4 CYT-2 Isoform Promotes the Transition from Colon Adenoma to Carcinoma Following APC loss. ( 26527747 )
2016
23
Influence of miRNA-106b and miRNA-135a on butyrate-regulated expression of p21 and Cyclin D2 in human colon adenoma cells. ( 26559563 )
2015
24
Diagnostic relevance of autoantibody detection against inhibitors of apoptosis proteins in colon cancer and colon adenoma. ( 26137273 )
2015
25
Sporadic nonampullary duodenal adenoma/carcinoma is associated with not only colon adenoma/carcinoma but also gastric cancer: association of location of duodenal lesions with comorbid diseases. ( 25582657 )
2015
26
Serum levels of retinol-binding protein 4 and risk of colon adenoma. ( 25712946 )
2015
27
PARP-1 expression is increased in colon adenoma and carcinoma and correlates with OGG1. ( 25526641 )
2014
28
Colon adenoma surveillance: it takes a program. ( 25127945 )
2014
29
Kallikrein-related peptidase 6 (KLK6) expression in the progression of colon adenoma to carcinoma. ( 25153391 )
2014
30
Sequential expression of miR-182 and miR-503 cooperatively targets FBXW7, contributing to the malignant transformation of colon adenoma to adenocarcinoma. ( 25269767 )
2014
31
Post-translational glycoprotein modifications regulate colon cancer stem cells and colon adenoma progression in Apc(min/+) mice through altered Wnt receptor signaling. ( 25274627 )
2014
32
The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression. ( 24952462 )
2014
33
Prerenal uremia induced by severe diarrhea due to colon adenoma: a case of McKittrick-Wheelock syndrome in an elderly patient. ( 28509250 )
2014
34
Inflammation of colon adenoma in the setting of type 1 autoimmune pancreatitis. ( 24629174 )
2014
35
Immunohistochemical and Western blot analysis of two protein tyrosine phosphatase receptors, R and Z1, in colorectal carcinoma, colon adenoma and normal colon tissues. ( 24242166 )
2014
36
Proteomics of differential extraction fractions enriched for chromatin-binding proteins from colon adenoma and carcinoma tissues. ( 24361553 )
2014
37
Adult ileal duplication revealed by a colon adenoma. ( 23778950 )
2013
38
No Association between Circulating Levels and Genetic Variants of IL-6 and TNF-α and Colon Adenoma. ( 24235998 )
2013
39
Celecoxib and tauro-ursodeoxycholic acid co-treatment inhibits cell growth in familial adenomatous polyposis derived LT97 colon adenoma cells. ( 22366264 )
2012
40
The Immunohistochemical Expression of STAT3, Bcl-xL, and MMP-2 Proteins in Colon Adenoma and Adenocarcinoma. ( 22375170 )
2012
41
Racial differences in measures of obesity and risk of colon adenoma. ( 21996657 )
2012
42
Physical activity and risk of colon adenoma: a meta-analysis. ( 21304525 )
2011
43
The diagnostic accuracy of high-resolution endoscopy, autofluorescence imaging and narrow-band imaging for differentially diagnosing colon adenoma. ( 21732270 )
2011
44
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. ( 21889923 )
2011
45
Case-control study of vitamin D, dickkopf homolog 1 (DKK1) gene methylation, VDR gene polymorphism and the risk of colon adenoma in African Americans. ( 22022386 )
2011
46
Conscious or unconscious: the impact of sedation choice on colon adenoma detection. ( 22025879 )
2011
47
Metabolic syndrome, lifestyle risk factors, and distal colon adenoma: a retrospective cohort study. ( 22046093 )
2011
48
Streptococcus bovis bacteremia related to colon adenoma in a chronic hemodialysis patient. ( 19758303 )
2010
49
Asymptomatic colon adenoma associated with Schistosoma mansoni. ( 19948430 )
2010
50
Genetic polymorphisms in vitamin D receptor VDR/RXRA influence the likelihood of colon adenoma recurrence. ( 20145122 )
2010

Variations for Colon Adenoma

Expression for Colon Adenoma

Search GEO for disease gene expression data for Colon Adenoma.

Pathways for Colon Adenoma

GO Terms for Colon Adenoma

Biological processes related to Colon Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.26 APC CASP3
2 cellular glucuronidation GO:0052695 9.16 UGT1A1 UGT2B7
3 striated muscle cell differentiation GO:0051146 8.96 CASP3 KRAS
4 response to glucocorticoid GO:0051384 8.8 CASP3 KRAS UGT1A1

Molecular functions related to Colon Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring hexosyl groups GO:0016758 9.26 UGT1A1 UGT2B7
2 glucuronosyltransferase activity GO:0015020 9.16 UGT1A1 UGT2B7
3 retinoic acid binding GO:0001972 8.96 UGT1A1 UGT2B7
4 UDP-glycosyltransferase activity GO:0008194 8.62 UGT1A1 UGT2B7

Sources for Colon Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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