MCID: CLN044
MIFTS: 41

Colon Adenoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Colon Adenoma

MalaCards integrated aliases for Colon Adenoma:

Name: Colon Adenoma 12 15
Adenomatous Polyp of Colon 72

Classifications:



External Ids:

Disease Ontology 12 DOID:0050912
UMLS 72 C0850572

Summaries for Colon Adenoma

Disease Ontology : 12 A colonic benign neoplasm that has material basis in epithelial tissue with glandular origin.

MalaCards based summary : Colon Adenoma, also known as adenomatous polyp of colon, is related to colorectal adenoma and adenocarcinoma. An important gene associated with Colon Adenoma is APC (APC Regulator Of WNT Signaling Pathway), and among its related pathways/superpathways are Nanog in Mammalian ESC Pluripotency and PI3K-Akt signaling pathway. The drugs nivolumab and Cola have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and testes, and related phenotypes are cellular and growth/size/body region

Related Diseases for Colon Adenoma

Diseases related to Colon Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 colorectal adenoma 31.2 VDR KRAS APC
2 adenocarcinoma 30.8 VEGFA KRAS EGF APC
3 lynch syndrome 30.4 OGG1 KRAS APC
4 colon adenocarcinoma 29.6 KRAS CASP3 APC
5 large intestine cancer 27.1 VEGFA VDR OGG1 MACC1 LGR5 KRAS
6 colorectal cancer 11.8
7 polyposis syndrome, hereditary mixed, 1 11.6
8 familial adenomatous polyposis 4 11.4
9 polyposis syndrome, hereditary mixed, 2 11.3
10 familial adenomatous polyposis 3 11.3
11 adenoma 11.0
12 attenuated familial adenomatous polyposis 10.5 OGG1 APC
13 hyperplastic polyposis syndrome 10.5 KRAS APC
14 periampullary adenoma 10.5 KRAS APC
15 mutyh-associated polyposis 10.4 KRAS APC
16 familial adenomatous polyposis 10.4
17 barrett's adenocarcinoma 10.3 OGG1 KRAS GSTT2
18 colonic benign neoplasm 10.3 LGR5 KRAS
19 intestinal benign neoplasm 10.3 LGR5 KRAS APC
20 villous adenoma 10.2
21 colitis 10.1
22 in situ carcinoma 10.1
23 helicobacter pylori infection 10.1
24 hyperinsulinism 10.0
25 acromegaly 10.0
26 ulcerative colitis 10.0
27 renal pelvis carcinoma 10.0 VEGFA MACC1
28 body mass index quantitative trait locus 11 10.0
29 body mass index quantitative trait locus 9 10.0
30 body mass index quantitative trait locus 8 10.0
31 body mass index quantitative trait locus 4 10.0
32 body mass index quantitative trait locus 10 10.0
33 body mass index quantitative trait locus 7 10.0
34 body mass index quantitative trait locus 12 10.0
35 body mass index quantitative trait locus 14 10.0
36 body mass index quantitative trait locus 18 10.0
37 body mass index quantitative trait locus 19 10.0
38 body mass index quantitative trait locus 20 10.0
39 familial colorectal cancer 10.0
40 respiratory system cancer 9.9 VEGFA KRAS CASP3
41 gastrointestinal system cancer 9.9 VEGFA KRAS CASP3
42 respiratory system disease 9.9 VEGFA KRAS CASP3
43 familial adenomatous polyposis 1 9.9
44 polyposis, skin pigmentation, alopecia, and fingernail changes 9.9
45 retinoblastoma 9.9
46 barrett esophagus 9.9
47 inflammatory bowel disease 9.9
48 diarrhea 9.9
49 gangliocytoma 9.9
50 signet ring cell adenocarcinoma 9.9

Graphical network of the top 20 diseases related to Colon Adenoma:



Diseases related to Colon Adenoma

Symptoms & Phenotypes for Colon Adenoma

MGI Mouse Phenotypes related to Colon Adenoma:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.21 APC CASP3 DKK1 HDAC2 KRAS LGR5
2 growth/size/body region MP:0005378 10.21 APC CASP3 CTBP1 DKK1 EGF HDAC2
3 mortality/aging MP:0010768 10.16 APC CASP3 CTBP1 DKK1 HDAC2 KRAS
4 digestive/alimentary MP:0005381 10.14 APC CASP3 EGF HDAC2 KRAS LGR5
5 endocrine/exocrine gland MP:0005379 10.13 APC CASP3 EGF HDAC2 KRAS LGR5
6 integument MP:0010771 10.1 APC CASP3 EGF HDAC2 KRAS LGR5
7 craniofacial MP:0005382 10.09 APC CASP3 DKK1 KRAS LGR5 VDR
8 nervous system MP:0003631 10.02 APC CASP3 CTBP1 DKK1 HDAC2 KRAS
9 muscle MP:0005369 9.98 APC CASP3 CTBP1 HDAC2 KRAS VDR
10 limbs/digits/tail MP:0005371 9.95 APC DKK1 HDAC2 KRAS VDR VEGFA
11 neoplasm MP:0002006 9.88 APC HDAC2 KRAS LGR5 OGG1 VEGFA
12 renal/urinary system MP:0005367 9.87 APC CASP3 DKK1 KRAS LGR5 VDR
13 reproductive system MP:0005389 9.8 APC CASP3 EGF HDAC2 KRAS VDR
14 respiratory system MP:0005388 9.63 CASP3 DKK1 HDAC2 KRAS LGR5 VEGFA
15 skeleton MP:0005390 9.56 APC CASP3 CTBP1 DKK1 HDAC2 KRAS
16 vision/eye MP:0005391 9.17 APC CASP3 DKK1 EGF HDAC2 KRAS

Drugs & Therapeutics for Colon Adenoma

Drugs for Colon Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Cola Phase 2
3 Antineoplastic Agents, Immunological Phase 2
4 Liver Extracts

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 A Phase II Study of PD-1 Inhibition for the Prevention of Colon Adenomas in Patients With Lynch Syndrome and a History of Partial Colectomy Suspended NCT03631641 Phase 2
2 Usefulness of Fecal Calprotectin for Screening Colon Adenoma in Korean Population Unknown status NCT01719198
3 Computer-assisted Detection of Colonic Polyps Unknown status NCT02838888
4 Effect of a Tracking Program on Colon Adenoma Surveillance and Adherence to Guideline Recommendations Unknown status NCT01713881
5 Impact of Diverticular Disease on the Detection of Colon Adenomas Unknown status NCT02057562
6 A Randomized Controlled Trial Comparing High-definition White Light Colonoscopy to I-scan Enhanced Colonoscopy for Adenoma Detection in a Population at Increased Risk of Colorectal Cancer (Main Study) Unknown status NCT02016326
7 Side Specific Withdrawal Times for Colonoscopy: Impact on Adenoma Detection in the Proximal and Distal Colon Completed NCT02819492
8 Impact of Second Forward View Examination of Proximal Colon on Adenoma Detection Rate: A Randomized Clinical Trial Completed NCT03619122
9 Effect of Video Monitor Size on Adenoma Detection Rate Completed NCT01952418
10 Familial Factors in the Development of Colon Cancer Completed NCT00055848
11 Single Center Prospective Evaluation Utilizing a Double Balloon Accessory Device to Facilitate Complex Endoscopic Polypectomy in Large Intestine Completed NCT03551379
12 Accuracy of the Optical Diagnosis of Small Colonic Polyps Using the Nice Classification Completed NCT02009774
13 Tandem Colonoscopy Study of Linked Color Imaging Versus Narrow Band Imaging on Colorectal Adenoma Detection: A Prospective, Randomized Study Completed NCT03336359
14 Comparison of Colon Adenoma Detection Rate Using Two Distal Colonoscope Attachments Completed NCT02665741
15 Endoscopic Evaluation in Transplantation Candidates - Frequency and Prognostic Relevance of Upper and Lower Gastrointestinal Tract Findings Completed NCT00990470
16 A Clinical Validation Study of Two Computerized Systems Called the 3D-Colonoscopy Progression Score and 3D-Colonoscopy Retraction Score Completed NCT03587935
17 Multi-center Prospective Registry Study Utilizing a Double Balloon Accessory Device to Facilitate Endoscopic Polypectomy in Large Intestine. Recruiting NCT03942965
18 The Utility of Time Segmental Withdrawal During Screening Colonoscopy for Increasing Adenoma Detection Rate. A Randomized Controlled Clinical Trial. Recruiting NCT02538406
19 LCI (Linked Color Imaging) for Adenoma Detection in the Right Colon Recruiting NCT03279783
20 Prospective Randomized Control Trial (RCT) of Water Exchange (WE) vs. WE Plus Cap-assisted Colonoscopy Recruiting NCT03543124
21 Trainee Participation Increases Colon Adenoma Detection Rate: a Randomized Controlled Trial Recruiting NCT03908229
22 Linked Color Imaging (LCI) Versus Standard White-light Colonoscopy for Colorectal Adenoma Detection: a Multicenter, Randomized, Trial Recruiting NCT03690297
23 Blue Laser Imaging Versus Narrow Band Imaging Versus White Light Imaging for Detection of Adenoma in the Proximal Colon: A Prospective Randomized Study Recruiting NCT03696992
24 Comparing Right Colon Adenoma and Hyperplastic Polyp Miss Rate in Colonoscopy Using Water Exchange and Carbon Dioxide Insufflation: A Prospective Randomized Controlled Trial Recruiting NCT03845933
25 PLA Army General Hospital of Beijing Recruiting NCT03781648
26 The Australian Colonic Large Sessile Lesion Endoscopic Resection Study Recruiting NCT03471793
27 Correlation Between Surrogate Quality Indicators for Adenoma Detection Rate (ADR) and Adenoma Miss Rate (AMR) in Qualified Colonoscopy: CORE Study Recruiting NCT03919487
28 Risk Factors of Inadequate Bowel Cleansing in Inpatients: a Predictive Score Not yet recruiting NCT03902561
29 Risk Factors of Inadequate Bowel Cleansing in Colon Capsule Endoscopy Not yet recruiting NCT03933371
30 NBI Versus White Light Endoscopy for Optical Characterization of Neoplastic Polyps in the Colorectum - the ADOPTION II Study Not yet recruiting NCT03679429

Search NIH Clinical Center for Colon Adenoma

Genetic Tests for Colon Adenoma

Anatomical Context for Colon Adenoma

MalaCards organs/tissues related to Colon Adenoma:

41
Colon, Liver, Testes, Breast, Skin, Pancreas, Lymph Node

Publications for Colon Adenoma

Articles related to Colon Adenoma:

(show top 50) (show all 333)
# Title Authors PMID Year
1
Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15. 38
31389184 2019
2
G protein-coupled receptor LGR6 is an independent risk factor for colon adenocarcinoma. 38
29971639 2019
3
Antioxidative, Anti-Inflammatory, and Anticancer Effects of Purified Flavonol Glycosides and Aglycones in Green Tea. 38
31387266 2019
4
Meta-Analysis of Cancer Triploidy: Rearrangements of Genome Complements in Male Human Tumors Are Characterized by XXY Karyotypes. 38
31412657 2019
5
Patients with breast cancer may be at higher risk of colorectal neoplasia. 38
31263363 2019
6
Dose-response meta-analysis of coffee consumption and risk of colorectal adenoma. 38
31308476 2019
7
[Comparison of endoscopic features between colorectal sessile serrated adenoma/polyp with or without cytologic dysplasia and hyperplastic polyp]. 38
31434395 2019
8
Metaproteomics of fecal samples of Crohn's disease and Ulcerative Colitis. 38
31009805 2019
9
Randomized control trial of adenoma detection rate in Endocuff-assisted colonoscopy versus transparent hood-assisted colonoscopy. 38
31254485 2019
10
Colon adenoma and adenocarcinoma with clear cell components - two case reports. 38
31077226 2019
11
The benefit of adding oral simethicone in bowel preparation regimen for the detection of colon adenoma: A systematic review and meta-analysis. 38
30311262 2019
12
Tumor response to irinotecan is associated with CYP3A5 expression in colorectal cancer. 38
30881507 2019
13
Redox, immune and genetic biomarker system for personalized treatments in colorectal cancer. 38
30788039 2019
14
Compared Abilities of Endoscopic Techniques to Increase Colon Adenoma Detection Rates: A Network Meta-analysis. 38
30529731 2018
15
The ASAMET trial: a randomized, phase II, double-blind, placebo-controlled, multicenter, 2 × 2 factorial biomarker study of tertiary prevention with low-dose aspirin and metformin in stage I-III colorectal cancer patients. 38
30514262 2018
16
Clonal Structures of Regionally Synchronous Gastric Adenomas and Carcinomas. 38
29945994 2018
17
ACTL6A expression promotes invasion, metastasis and epithelial mesenchymal transition of colon cancer. 38
30348114 2018
18
Clinical Value of CXCL5 for Determining of Colorectal Cancer 38
30255816 2018
19
Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors. 38
29524208 2018
20
Comparative Efficacy of Colonoscope Distal Attachment Devices in Increasing Rates of Adenoma Detection: A Network Meta-analysis. 38
29133257 2018
21
Mutation analysis of adenomas and carcinomas of the colon: Early and late drivers. 38
29575536 2018
22
Gut immunoglobulin alpha anti-glycan binding profiles as a research tool for local disease detection. 38
29926273 2018
23
Evaluation of Patients with an Apparent False Positive Stool DNA Test: The Role of Repeat Stool DNA Testing. 38
29516325 2018
24
Colon adenoma with 2 too-long stalks (with video). 38
29223383 2018
25
Pharmacological and dietary factors in prevention of colorectal cancer. 38
30149368 2018
26
Linked color imaging reduces the miss rate of neoplastic lesions in the right colon: a randomized tandem colonoscopy study. 38
29539651 2018
27
Identification, isolation and characterization of human LGR5-positive colon adenoma cells. 38
29467240 2018
28
Sessile serrated adenoma detection rate is correlated with adenoma detection rate. 38
29564038 2018
29
Influence of roasting on the chemopreventive potential of in vitro fermented almonds in LT97 colon adenoma cells. 38
28583046 2018
30
The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma. 38
29422500 2018
31
Detection rate and proximal shift tendency of adenomas and serrated polyps: a retrospective study of 62,560 colonoscopies. 38
29282495 2018
32
Specific clones of Staphylococcus lugdunensis may be associated with colon carcinoma. 38
28506660 2018
33
Prevalence and characteristics of colonic adenoma in mainland China. 38
30147371 2018
34
Droplet digital PCR is an accurate method to assess methylation status on FFPE samples. 38
29527977 2018
35
Chemopreventive Potential of In Vitro Fermented Raw and Roasted Hazelnuts in LT97 Colon Adenoma Cells. 38
29277760 2018
36
Feasibility of CYFRA 21-1 as a serum biomarker for the detection of colorectal adenoma and advanced colorectal adenoma in people over the age of 45. 38
28186354 2018
37
Adiponectin, Leptin, IGF-1, and Tumor Necrosis Factor Alpha As Potential Serum Biomarkers for Non-Invasive Diagnosis of Colorectal Adenoma in African Americans. 38
29593647 2018
38
Different effects of metformin and insulin on primary and secondary chemoprevention of colorectal adenoma in diabetes type 2: Traditional and Bayesian meta-analysis. 38
29383018 2018
39
Hyperglycemia combined Helicobacter pylori infection increases risk of synchronous colorectal adenoma and carotid artery plaque. 38
29312558 2017
40
TBX19 is overexpressed in colorectal cancer and associated with lymph node metastasis. 38
29199261 2017
41
Chemopreventive Potential of Raw and Roasted Pistachios Regarding Colon Carcinogenesis. 38
29258268 2017
42
Altered microRNA profiles during early colon adenoma progression in a porcine model of familial adenomatous polyposis. 38
29221194 2017
43
In vitro-fermented raw and roasted walnuts induce expression of CAT and GSTT2 genes, growth inhibition, and apoptosis in LT97 colon adenoma cells. 38
29241580 2017
44
Endocuff-assisted colonoscopy is associated with a lower adenoma miss rate: a multicenter randomized tandem study. 38
28763808 2017
45
EpiGeNet: A Graph Database of Interdependencies Between Genetic and Epigenetic Events in Colorectal Cancer. 38
27627442 2017
46
Molecular Imaging of Colorectal Tumors by Targeting Colon Cancer Secreted Protein-2 (CCSP-2). 38
28886423 2017
47
Synergistic Effect of Hyperglycemia and Helicobacterpylori Infection Status on Colorectal Adenoma Risk. 38
28475740 2017
48
Benralizumab for patients with mild to moderate, persistent asthma (BISE): a randomised, double-blind, placebo-controlled, phase 3 trial. 38
28545978 2017
49
Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer: impact on tumor growth and cell migration. 38
28418886 2017
50
Chemopreventive potential of in vitro fermented nuts in LT97 colon adenoma and primary epithelial colon cells. 38
27996158 2017

Variations for Colon Adenoma

Expression for Colon Adenoma

Search GEO for disease gene expression data for Colon Adenoma.

Pathways for Colon Adenoma

Pathways related to Colon Adenoma according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.06 VEGFA KRAS EGF CTBP1 CASP3 APC
2
Show member pathways
12.72 VEGFA KRAS HDAC2 EGF CASP3 APC
3 12.61 VEGFA KRAS EGF CASP3
4
Show member pathways
12.61 KRAS GSTT2 EGF APC
5 12.32 VEGFA KRAS CASP3 APC
6
Show member pathways
12.27 LGR5 DKK1 APC
7
Show member pathways
12.24 VEGFA KRAS HDAC2 EGF CTBP1 CASP3
8 11.99 VEGFA KRAS CASP3
9 11.95 VEGFA KRAS HDAC2 GSTT2 EGF CTBP1
10 11.91 VEGFA HDAC2 CTBP1
11 11.81 KRAS CYP2C9 CASP3
12 11.79 KRAS EGF APC
13 11.79 VEGFA LGR5 EGF DKK1
14 11.78 DKK1 CASP3 APC
15 11.77 VEGFA KRAS EGF CASP3 APC
16 11.74 VDR HDAC2 DKK1 APC
17 11.72 VEGFA KRAS CASP3
18 11.57 VDR HDAC2 CTBP1
19 11.56 VEGFA HDAC2 CTBP1
20 11.53 VEGFA KRAS EGF
21 11.46 HDAC2 DKK1 CTBP1 APC
22 11.45 DKK1 CASP3 APC
23 11.33 VEGFA EGF DKK1
24 11.3 DKK1 CTBP1 APC
25 11.24 VEGFA KRAS EGF
26 11.06 KRAS EGF
27
Show member pathways
11.04 KRAS EGF
28 11 DKK1 APC
29 10.93 VEGFA EGF CASP3
30 10.88 UGT2B7 CYP2C9
31 10.7 EGF CASP3

GO Terms for Colon Adenoma

Biological processes related to Colon Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.77 VEGFA VDR HDAC2 DKK1 CTBP1
2 negative regulation of apoptotic process GO:0043066 9.55 VEGFA OGG1 HDAC2 DKK1 CASP3
3 branching morphogenesis of an epithelial tube GO:0048754 9.46 VEGFA EGF
4 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.43 CASP3 APC
5 positive regulation of receptor internalization GO:0002092 9.4 VEGFA EGF
6 mammary gland alveolus development GO:0060749 9.32 VEGFA EGF
7 striated muscle cell differentiation GO:0051146 9.26 KRAS CASP3
8 positive regulation of MAP kinase activity GO:0043406 9.13 VEGFA KRAS EGF
9 positive regulation of gene expression GO:0010628 9.02 VEGFA VDR KRAS EGF DKK1

Molecular functions related to Colon Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.92 VEGFA MACC1 EGF DKK1

Sources for Colon Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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