MCID: CLN004
MIFTS: 24

Colon Carcinoma in Situ

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Colon Carcinoma in Situ

MalaCards integrated aliases for Colon Carcinoma in Situ:

Name: Colon Carcinoma in Situ 12 15
Carcinoma in Situ of Colon 12
Stage 0 Carcinoma of Colon 70
Stage 0 Colonic Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8826
ICD9CM 34 230.3
SNOMED-CT 67 92568009
ICD10 32 D01.0
UMLS 70 C0154061

Summaries for Colon Carcinoma in Situ

Disease Ontology : 12 An intestine carcinoma in situ that is located in the colon.

MalaCards based summary : Colon Carcinoma in Situ, also known as carcinoma in situ of colon, is related to colon adenocarcinoma and in situ carcinoma. An important gene associated with Colon Carcinoma in Situ is CEACAM7 (CEA Cell Adhesion Molecule 7), and among its related pathways/superpathways are Degradation of the extracellular matrix and Cell surface interactions at the vascular wall. Affiliated tissues include colon, and related phenotypes are Decreased vesicular stomatitis virus (VSV) infection and Decreased vesicular stomatitis virus (VSV) infection

Related Diseases for Colon Carcinoma in Situ

Diseases related to Colon Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 colon adenocarcinoma 10.0
2 in situ carcinoma 10.0
3 polyarteritis nodosa 9.6 ICAM3 ICAM2
4 intestine carcinoma in situ 8.5 UBXN11 SLC3A2 ITGA1 ICAM3 ICAM2 CD99

Comorbidity relations with Colon Carcinoma in Situ via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Ascending Colon Cancer
Cecal Benign Neoplasm

Symptoms & Phenotypes for Colon Carcinoma in Situ

GenomeRNAi Phenotypes related to Colon Carcinoma in Situ according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-1 8.8 CEACAM7 ITGA1
2 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-2 8.8 CEACAM7

Drugs & Therapeutics for Colon Carcinoma in Situ

Search Clinical Trials , NIH Clinical Center for Colon Carcinoma in Situ

Genetic Tests for Colon Carcinoma in Situ

Anatomical Context for Colon Carcinoma in Situ

The Foundational Model of Anatomy Ontology organs/tissues related to Colon Carcinoma in Situ:

19
Colon

MalaCards organs/tissues related to Colon Carcinoma in Situ:

40
Colon

Publications for Colon Carcinoma in Situ

Articles related to Colon Carcinoma in Situ:

# Title Authors PMID Year
1
TisN0M1 Sigmoid Colon Cancer: A Case Report. 61
24999466 2014
2
Activated T lymphocytes bind in situ to stromal tissue of colon carcinoma but lack adhesion to tumor cells. 61
11169447 2001
3
Transcription of carcinoembryonic antigen in normal colon and colon carcinoma. In situ hybridization study and implication for a new in vivo functional model. 61
8317550 1993

Variations for Colon Carcinoma in Situ

Expression for Colon Carcinoma in Situ

Search GEO for disease gene expression data for Colon Carcinoma in Situ.

Pathways for Colon Carcinoma in Situ

GO Terms for Colon Carcinoma in Situ

Cellular components related to Colon Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.1 SLC3A2 ITGA1 ICAM3 ICAM2 CEACAM7 CD99

Biological processes related to Colon Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.33 ITGA1 ICAM3 ICAM2
2 cell-cell adhesion GO:0098609 9.32 ICAM3 ICAM2
3 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.26 ICAM3 ICAM2
4 regulation of immune response GO:0050776 9.13 ICAM3 ICAM2 CD99
5 cell adhesion GO:0007155 8.92 ITGA1 ICAM3 ICAM2 CD99

Molecular functions related to Colon Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 8.62 ICAM3 ICAM2

Sources for Colon Carcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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