MCID: CLN004
MIFTS: 35

Colon Carcinoma in Situ

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Colon Carcinoma in Situ

MalaCards integrated aliases for Colon Carcinoma in Situ:

Name: Colon Carcinoma in Situ 12 15
Carcinoma in Situ of Colon 12
Stage 0 Carcinoma of Colon 73
Stage 0 Colonic Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8826
ICD10 33 D01.0
ICD9CM 35 230.3
NCIt 50 C3638
SNOMED-CT 68 189230008 92568009
UMLS 73 C0154061

Summaries for Colon Carcinoma in Situ

MalaCards based summary : Colon Carcinoma in Situ, also known as carcinoma in situ of colon, is related to fibrolamellar carcinoma and cd3zeta deficiency. An important gene associated with Colon Carcinoma in Situ is TGFB3 (Transforming Growth Factor Beta 3), and among its related pathways/superpathways are Integrin Pathway and Response to elevated platelet cytosolic Ca2+. The drugs Cola and Trastuzumab have been mentioned in the context of this disorder. Affiliated tissues include colon, appendix and breast, and related phenotypes are cellular and immune system

Related Diseases for Colon Carcinoma in Situ

Diseases related to Colon Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 fibrolamellar carcinoma 10.4 ITGA1 ITGAV
2 cd3zeta deficiency 10.3 CD44 NCAM1
3 lethal midline granuloma 10.2 ICAM1 NCAM1
4 rheumatoid vasculitis 10.0 CD44 ICAM1
5 actinic prurigo 9.8 ICAM1 ICAM3
6 malignant skin fibrous histiocytoma 9.8 CD99 NCAM1
7 malignant dermis tumor 9.6 CD99 NCAM1

Comorbidity relations with Colon Carcinoma in Situ via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Ascending Colon Cancer
Cecal Benign Neoplasm

Graphical network of the top 20 diseases related to Colon Carcinoma in Situ:



Diseases related to Colon Carcinoma in Situ

Symptoms & Phenotypes for Colon Carcinoma in Situ

MGI Mouse Phenotypes related to Colon Carcinoma in Situ:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.65 TGFB3 CD44 ICAM1 ITGA1 ITGA2 ITGA5
2 immune system MP:0005387 9.28 SLC3A2 TGFB3 CD44 ICAM1 ICAM2 ITGA1

Drugs & Therapeutics for Colon Carcinoma in Situ

Drugs for Colon Carcinoma in Situ (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola Nutraceutical Phase 3,Phase 1
2
Trastuzumab Approved, Investigational Phase 2 180288-69-1 9903
3
Bevacizumab Approved, Investigational Phase 2 216974-75-3
4 Angiogenesis Inhibitors Phase 2
5 Angiogenesis Modulating Agents Phase 2
6
Capecitabine Approved, Investigational Phase 1 154361-50-9 60953
7
Oxaliplatin Approved, Investigational Phase 1 61825-94-3 5310940 9887054 43805 6857599
8 Antimetabolites Phase 1
9 Antimetabolites, Antineoplastic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Conventional Surgery Compared With Laparoscopic-Assisted Surgery in Treating Patients With Colorectal Cancer Completed NCT00003354 Phase 3
2 A Study of Avastin (Bevacizumab) Plus Herceptin (Trastuzumab) in Patients With Primary Inflammatory HER2-Positive Breast Cancer. Completed NCT00717405 Phase 2 Standard chemotherapy;bevacizumab [Avastin];trastuzumab [Herceptin]
3 Oxaliplatin Plus Capecitabine in Treating Patients With Colorectal, Appendix, or Small Bowel Cancer Completed NCT00019773 Phase 1 capecitabine;oxaliplatin

Search NIH Clinical Center for Colon Carcinoma in Situ

Genetic Tests for Colon Carcinoma in Situ

Anatomical Context for Colon Carcinoma in Situ

MalaCards organs/tissues related to Colon Carcinoma in Situ:

41
Colon, Appendix, Breast

Publications for Colon Carcinoma in Situ

Articles related to Colon Carcinoma in Situ:

# Title Authors Year
1
Transcription of carcinoembryonic antigen in normal colon and colon carcinoma. In situ hybridization study and implication for a new in vivo functional model. ( 8317550 )
1993

Variations for Colon Carcinoma in Situ

Cosmic variations for Colon Carcinoma in Situ:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM532 KRAS large intestine,colon,other,carcinoma in situ c.38G>A p.G13D 12:25245347-25245347 8
2 COSM521 KRAS large intestine,colon,other,carcinoma in situ c.35G>A p.G12D 12:25245350-25245350 8
3 COSM522 KRAS large intestine,colon,other,carcinoma in situ c.35G>C p.G12A 12:25245350-25245350 8
4 COSM520 KRAS large intestine,colon,other,carcinoma in situ c.35G>T p.G12V 12:25245350-25245350 8

Expression for Colon Carcinoma in Situ

Search GEO for disease gene expression data for Colon Carcinoma in Situ.

Pathways for Colon Carcinoma in Situ

Pathways related to Colon Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 CD99 ICAM1 ICAM2 ITGA1 ITGA2 ITGA5
2
Show member pathways
13.1 CD44 CD99 ITGA1 ITGA2 ITGA5 ITGAV
3
Show member pathways
12.95 ITGA1 ITGA2 ITGA5 ITGAV TGFB3
4
Show member pathways
12.83 ITGA1 ITGA2 ITGA5 ITGAV TGFB3
5
Show member pathways
12.82 ITGA1 ITGA2 ITGA5 ITGAV
6
Show member pathways
12.77 ITGA1 ITGA2 ITGA5 ITGAV TGFB3
7
Show member pathways
12.68 ITGA1 ITGA2 ITGA5 ITGAV
8
Show member pathways
12.53 ITGA1 ITGA2 ITGA5 ITGAV
9 12.51 ITGA1 ITGA2 ITGA5 ITGAV
10
Show member pathways
12.34 ITGA1 ITGA2 ITGA5 ITGAV
11 12.22 CD44 ITGA2 ITGA5 ITGAV
12
Show member pathways
12.11 ITGA1 ITGA2 ITGA5 ITGAV TGFB3
13 12.08 ITGA1 ITGA2 ITGA5 ITGAV
14
Show member pathways
12.05 CD44 CD99 ITGA5 ITGAV SELPLG SLC3A2
15 12.03 ITGA2 ITGA5 ITGAV
16
Show member pathways
12.03 ITGA1 ITGA2 ITGA5 ITGAV
17
Show member pathways
11.98 CD44 ICAM1 ICAM2 ICAM3 ITGA1 ITGA2
18 11.97 ICAM1 ICAM2 ICAM3
19
Show member pathways
11.93 ITGA1 ITGA2 ITGA5 ITGAV NCAM1
20 11.92 CD44 ITGA2 ITGAV NCAM1
21 11.86 CD99 ICAM1 ICAM2 ICAM3 ITGAV NCAM1
22 11.82 CD44 ICAM1 ICAM2 ITGA5 ITGAV NCAM1
23 11.81 CD44 ITGA1 ITGA2 ITGA5
24 11.77 ITGA5 ITGAV TGFB3
25 11.73 ITGA1 ITGA2 ITGA5 ITGAV
26
Show member pathways
11.73 CD44 ICAM1 ICAM2 ICAM3 ITGA1 ITGA2
27
Show member pathways
11.67 ITGA5 ITGAV TGFB3
28 11.58 CD44 ITGA1 ITGA5
29 11.57 ITGA1 ITGA2 ITGA5 ITGAV
30 11.51 ITGA2 ITGAV NCAM1 TGFB3
31 11.46 ICAM1 ICAM2 SELPLG
32 11.45 ITGA1 ITGA2 ITGA5 ITGAV
33 11.41 ICAM1 ICAM2 ICAM3
34 11.31 ITGA1 ITGA2 ITGA5 ITGAV
35 11.3 CD44 ITGA2 ITGA5
36 11.19 ITGA2 ITGA5
37 11.07 ITGA1 ITGA2 ITGA5
38 11.01 ICAM2 ICAM3
39 11.01 ITGA5 ITGAV NCAM1
40 10.76 ITGA1 ITGA2

GO Terms for Colon Carcinoma in Situ

Cellular components related to Colon Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.95 CD44 CD99 ICAM1 ICAM2 ICAM3 ITGAV
2 external side of plasma membrane GO:0009897 9.8 ICAM1 ITGA1 ITGA2 ITGA5 ITGAV NCAM1
3 integrin complex GO:0008305 9.56 ITGA1 ITGA2 ITGA5 ITGAV
4 lamellipodium membrane GO:0031258 9.51 CD44 ITGAV
5 focal adhesion GO:0005925 9.5 CD44 CD99 ICAM1 ITGA1 ITGA2 ITGA5
6 basal part of cell GO:0045178 9.48 ITGA1 ITGA2
7 uropod GO:0001931 9.46 ICAM2 SELPLG
8 cell surface GO:0009986 9.28 CD44 ICAM1 ITGA1 ITGA2 ITGA5 ITGAV
9 membrane GO:0016020 10.25 CD44 CD99 CEACAM7 ICAM1 ICAM2 ICAM3
10 integral component of membrane GO:0016021 10.18 CD44 CD99 CEACAM7 ICAM1 ICAM2 ICAM3
11 extracellular exosome GO:0070062 10.1 CD44 ICAM1 ICAM2 ICAM3 ITGA1 ITGAV
12 plasma membrane GO:0005886 10 CD44 CD99 CEACAM7 ICAM1 ICAM2 ICAM3

Biological processes related to Colon Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.85 ICAM1 ITGA2 ITGA5 ITGAV NCAM1 SELPLG
2 regulation of immune response GO:0050776 9.8 CD99 ICAM1 ICAM2 ICAM3
3 leukocyte migration GO:0050900 9.8 CD44 ICAM1 ITGA5 ITGAV SELPLG SLC3A2
4 cell-cell adhesion GO:0098609 9.78 CD44 ICAM1 ICAM2 ICAM3
5 response to hypoxia GO:0001666 9.77 ICAM1 ITGA2 TGFB3
6 cell-matrix adhesion GO:0007160 9.76 CD44 ITGA1 ITGA2 ITGAV
7 integrin-mediated signaling pathway GO:0007229 9.73 ITGA1 ITGA2 ITGA5 ITGAV
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.7 CD44 ICAM1 ITGA5
9 interferon-gamma-mediated signaling pathway GO:0060333 9.69 CD44 ICAM1 NCAM1
10 viral entry into host cell GO:0046718 9.63 ICAM1 ITGA2 ITGA5 ITGAV NCAM1 SELPLG
11 mammary gland development GO:0030879 9.61 ITGA2 TGFB3
12 endodermal cell differentiation GO:0035987 9.6 ITGA5 ITGAV
13 leukocyte cell-cell adhesion GO:0007159 9.58 ICAM1 ITGA5
14 positive regulation of collagen biosynthetic process GO:0032967 9.58 ITGA2 TGFB3
15 cell-substrate adhesion GO:0031589 9.58 ITGA2 ITGA5 ITGAV
16 heterotypic cell-cell adhesion GO:0034113 9.57 ITGA5 ITGAV
17 cell growth GO:0016049 9.56 SLC3A2 TGFB3
18 cell adhesion mediated by integrin GO:0033627 9.56 ICAM1 ITGA2 ITGA5 ITGAV
19 extracellular matrix organization GO:0030198 9.56 CD44 ICAM1 ICAM2 ICAM3 ITGA1 ITGA2
20 cellular response to interleukin-6 GO:0071354 9.55 ICAM1 SELPLG
21 positive regulation of SMAD protein signal transduction GO:0060391 9.54 RBPMS TGFB3
22 cell adhesion GO:0007155 9.36 CD44 CD99 ICAM1 ICAM2 ICAM3 ITGA1

Molecular functions related to Colon Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.67 ICAM3 ITGA1 ITGAV SELPLG
2 collagen binding GO:0005518 9.43 CD44 ITGA1 ITGA2
3 integrin binding GO:0005178 9.43 ICAM1 ICAM2 ICAM3 ITGA2 ITGA5 ITGAV
4 transforming growth factor beta binding GO:0050431 9.32 ITGAV TGFB3
5 collagen binding involved in cell-matrix adhesion GO:0098639 9.16 ITGA1 ITGA2
6 virus receptor activity GO:0001618 9.1 ICAM1 ITGA2 ITGA5 ITGAV NCAM1 SELPLG

Sources for Colon Carcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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