MCID: CLN004
MIFTS: 39

Colon Carcinoma in Situ

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Colon Carcinoma in Situ

MalaCards integrated aliases for Colon Carcinoma in Situ:

Name: Colon Carcinoma in Situ 12 15
Carcinoma in Situ of Colon 12
Stage 0 Carcinoma of Colon 74
Stage 0 Colonic Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8826
ICD9CM 36 230.3
SNOMED-CT 69 92568009
ICD10 34 D01.0
UMLS 74 C0154061

Summaries for Colon Carcinoma in Situ

Disease Ontology : 12 An in situ carcinoma that is located in the colon.

MalaCards based summary : Colon Carcinoma in Situ, also known as carcinoma in situ of colon, is related to middle cerebral artery infarction and cd3zeta deficiency. An important gene associated with Colon Carcinoma in Situ is TGFB3 (Transforming Growth Factor Beta 3), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Akt Signaling. The drugs Cola and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include colon, breast and appendix, and related phenotypes are Reduced mammosphere formation and cellular

Related Diseases for Colon Carcinoma in Situ

Diseases related to Colon Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 middle cerebral artery infarction 10.2 CD40LG NCAM1
2 cd3zeta deficiency 10.1 CD44 NCAM1
3 lethal midline granuloma 10.1 ICAM1 NCAM1
4 orbital plasma cell granuloma 10.1 CTLA4 NCAM1
5 chronic orbital inflammation 10.0 CTLA4 NCAM1
6 actinic prurigo 9.9 ICAM1 ICAM3
7 rheumatoid vasculitis 9.8 CD44 ICAM1
8 in situ carcinoma 9.8
9 malignant skin fibrous histiocytoma 9.7 CD99 CTLA4 NCAM1
10 malignant dermis tumor 9.7 CD99 CTLA4 NCAM1
11 intestine carcinoma in situ 7.6 CD40LG CD44 CD99 ICAM1 ICAM2 ICAM3

Comorbidity relations with Colon Carcinoma in Situ via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Ascending Colon Cancer
Cecal Benign Neoplasm

Graphical network of the top 20 diseases related to Colon Carcinoma in Situ:



Diseases related to Colon Carcinoma in Situ

Symptoms & Phenotypes for Colon Carcinoma in Situ

GenomeRNAi Phenotypes related to Colon Carcinoma in Situ according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 CD28 CD44 ICAM2 ITGA2 NCAM1 SELPLG

MGI Mouse Phenotypes related to Colon Carcinoma in Situ:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 CD28 CD40LG CD44 ICAM1 ITGA1 ITGA2
2 hematopoietic system MP:0005397 10.06 CD28 CD40LG CD44 CTLA4 ICAM1 ICAM2
3 cardiovascular system MP:0005385 10.03 CD40LG CD44 CTLA4 ICAM1 ITGA1 ITGA5
4 homeostasis/metabolism MP:0005376 10 CD28 CD40LG CD44 CTLA4 ICAM1 ITGA1
5 immune system MP:0005387 9.93 CD28 CD40LG CD44 CTLA4 ICAM1 ICAM2
6 digestive/alimentary MP:0005381 9.91 CD28 CD44 CTLA4 ICAM1 ITGAV SLC3A2
7 integument MP:0010771 9.5 CD28 CD40LG CD44 CTLA4 ICAM1 ITGA2
8 mortality/aging MP:0010768 9.36 CD40LG CD44 CTLA4 ICAM1 ITGA1 ITGA5

Drugs & Therapeutics for Colon Carcinoma in Situ

Drugs for Colon Carcinoma in Situ (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola Phase 3,Phase 1
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3
Trastuzumab Approved, Investigational Phase 2 180288-69-1 9903
4 Angiogenesis Inhibitors Phase 2
5 Angiogenesis Modulating Agents Phase 2
6 Antineoplastic Agents, Immunological Phase 2
7
Capecitabine Approved, Investigational Phase 1 154361-50-9 60953
8
Oxaliplatin Approved, Investigational Phase 1 61825-94-3 43805 6857599 5310940 9887054
9 Antimetabolites Phase 1
10 Antimetabolites, Antineoplastic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Conventional Surgery Compared With Laparoscopic-Assisted Surgery in Treating Patients With Colorectal Cancer Completed NCT00003354 Phase 3
2 A Study of Avastin (Bevacizumab) Plus Herceptin (Trastuzumab) in Patients With Primary Inflammatory HER2-Positive Breast Cancer. Completed NCT00717405 Phase 2 Standard chemotherapy;bevacizumab [Avastin];trastuzumab [Herceptin]
3 Oxaliplatin Plus Capecitabine in Treating Patients With Colorectal, Appendix, or Small Bowel Cancer Completed NCT00019773 Phase 1 capecitabine;oxaliplatin

Search NIH Clinical Center for Colon Carcinoma in Situ

Genetic Tests for Colon Carcinoma in Situ

Anatomical Context for Colon Carcinoma in Situ

MalaCards organs/tissues related to Colon Carcinoma in Situ:

42
Colon, Breast, Appendix, Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Colon Carcinoma in Situ:

20
The Colon

Publications for Colon Carcinoma in Situ

Articles related to Colon Carcinoma in Situ:

# Title Authors Year
1
Transcription of carcinoembryonic antigen in normal colon and colon carcinoma. In situ hybridization study and implication for a new in vivo functional model. ( 8317550 )
1993

Variations for Colon Carcinoma in Situ

Cosmic variations for Colon Carcinoma in Situ:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM43945 TP53 large intestine,colon,other,carcinoma in situ c.821T>G p.V274G 17:7673799-7673799 0
2 COSM532 KRAS large intestine,colon,other,carcinoma in situ c.38G>A p.G13D 12:25245347-25245347 0
3 COSM521 KRAS large intestine,colon,other,carcinoma in situ c.35G>A p.G12D 12:25245350-25245350 0
4 COSM522 KRAS large intestine,colon,other,carcinoma in situ c.35G>C p.G12A 12:25245350-25245350 0
5 COSM520 KRAS large intestine,colon,other,carcinoma in situ c.35G>T p.G12V 12:25245350-25245350 0

Expression for Colon Carcinoma in Situ

Search GEO for disease gene expression data for Colon Carcinoma in Situ.

Pathways for Colon Carcinoma in Situ

Pathways related to Colon Carcinoma in Situ according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.41 CD28 CD40LG CTLA4 ICAM1 ICAM2 ICAM3
2
Show member pathways
13.36 CD28 CD40LG ITGA1 ITGA2 ITGA5 ITGAV
3
Show member pathways
13.34 CD99 ICAM1 ICAM2 ITGA1 ITGA2 ITGA5
4
Show member pathways
13.19 CD44 CD99 ITGA1 ITGA2 ITGA5 ITGAV
5
Show member pathways
13 ITGA1 ITGA2 ITGA5 ITGAV TGFB3
6
Show member pathways
12.88 ITGA1 ITGA2 ITGA5 ITGAV TGFB3
7
Show member pathways
12.86 CD40LG ITGA1 ITGA2 ITGA5 ITGAV
8
Show member pathways
12.82 ITGA1 ITGA2 ITGA5 ITGAV TGFB3
9
Show member pathways
12.56 ITGA1 ITGA2 ITGA5 ITGAV
10 12.56 ITGA1 ITGA2 ITGA5 ITGAV
11
Show member pathways
12.51 CD44 ICAM1 ICAM2 ICAM3 ITGA1 ITGA2
12 12.49 CD28 CD40LG CD44 CTLA4 ICAM2 NCAM1
13
Show member pathways
12.38 ITGA1 ITGA2 ITGA5 ITGAV
14
Show member pathways
12.36 ITGA1 ITGA2 ITGA5 ITGAV TGFB3
15 12.26 CD44 ITGA2 ITGA5 ITGAV
16
Show member pathways
12.17 ITGA1 ITGA2 ITGA5 ITGAV
17
Show member pathways
12.17 ITGA1 ITGA2 ITGA5 ITGAV TGFB3
18
Show member pathways
12.12 CD99 ICAM1 ICAM2 ITGA1 ITGA2 ITGA5
19 12.1 ITGA1 ITGA2 ITGA5 ITGAV
20 12.07 ITGA2 ITGA5 ITGAV
21
Show member pathways
12.05 CD44 CD99 ITGA5 ITGAV SELPLG SLC3A2
22 12.04 CD40LG ICAM1 ICAM2 ICAM3
23 11.93 ITGA1 ITGA2 ITGA5 ITGAV
24
Show member pathways
11.93 ITGA1 ITGA2 ITGA5 ITGAV NCAM1
25 11.85 CD44 ITGA1 ITGA2 ITGA5
26 11.83 CD28 CD44 ITGA2 ITGAV NCAM1
27 11.82 ITGA5 ITGAV TGFB3
28 11.82 CD44 ICAM1 ICAM2 ITGA5 ITGAV NCAM1
29 11.81 CD28 CTLA4 ICAM1 TGFB3
30 11.77 ITGA1 ITGA2 ITGA5 ITGAV
31
Show member pathways
11.75 CD44 ICAM1 ICAM2 ICAM3 ITGA1 ITGA2
32
Show member pathways
11.73 CD40LG CTLA4 SLC3A2
33
Show member pathways
11.71 ITGA5 ITGAV TGFB3
34 11.69 ITGA1 ITGA2 ITGA5 ITGAV TGFB3
35 11.62 CD44 ITGA1 ITGA5
36 11.61 ITGA1 ITGA2 ITGA5 ITGAV
37 11.59 CD28 CD40LG CTLA4
38 11.57 ITGA2 ITGAV NCAM1 TGFB3
39 11.51 CD40LG ICAM1 TGFB3
40 11.5 ITGA1 ITGA2 ITGA5 ITGAV
41 11.49 ICAM1 ICAM2 SELPLG
42 11.49 CD28 CD40LG CD99 CTLA4 ICAM1 ICAM2
43 11.45 ICAM1 ICAM2 ICAM3
44 11.36 ITGA1 ITGA2 ITGA5 ITGAV TGFB3
45 11.35 CD44 ITGA2 ITGA5
46 11.31 ITGA1 ITGA2 ITGA5 ITGAV
47 11.11 ITGA1 ITGA2 ITGA5
48 11.06 ITGA5 ITGAV NCAM1
49 11.05 ICAM2 ICAM3
50 10.97 CD40LG ITGA1 ITGA2 ITGA5 ITGAV TGFB3

GO Terms for Colon Carcinoma in Situ

Cellular components related to Colon Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.96 CD28 CD40LG CD44 CD99 CTLA4 ICAM1
2 focal adhesion GO:0005925 9.91 CD44 CD99 ICAM1 ITGA1 ITGA2 ITGA5
3 integrin complex GO:0008305 9.62 ITGA1 ITGA2 ITGA5 ITGAV
4 external side of plasma membrane GO:0009897 9.61 CD28 CD40LG CTLA4 ICAM1 ITGA1 ITGA2
5 lamellipodium membrane GO:0031258 9.51 CD44 ITGAV
6 basal part of cell GO:0045178 9.49 ITGA1 ITGA2
7 uropod GO:0001931 9.48 ICAM2 SELPLG
8 protein complex involved in cell adhesion GO:0098636 9.46 CD28 CTLA4
9 cell surface GO:0009986 9.36 CD28 CD40LG CD44 ICAM1 ITGA1 ITGA2
10 membrane GO:0016020 10.34 CD28 CD40LG CD44 CD99 CEACAM7 CTLA4
11 integral component of membrane GO:0016021 10.28 CD28 CD40LG CD44 CD99 CTLA4 ICAM1
12 plasma membrane GO:0005886 10.09 CD28 CD40LG CD44 CD99 CEACAM7 CTLA4

Biological processes related to Colon Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.91 ICAM1 ITGA2 ITGA5 ITGAV NCAM1 SELPLG
2 cell-cell adhesion GO:0098609 9.81 CD44 ICAM1 ICAM2 ICAM3
3 regulation of immune response GO:0050776 9.8 CD40LG CD99 ICAM1 ICAM2 ICAM3
4 leukocyte migration GO:0050900 9.8 CD44 ICAM1 ITGA5 ITGAV SELPLG SLC3A2
5 cell-matrix adhesion GO:0007160 9.78 CD44 ITGA1 ITGA2 ITGAV
6 integrin-mediated signaling pathway GO:0007229 9.76 ITGA1 ITGA2 ITGA5 ITGAV
7 female pregnancy GO:0007565 9.73 ITGA2 ITGA5 TGFB3
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.72 CD44 ICAM1 ITGA5
9 interferon-gamma-mediated signaling pathway GO:0060333 9.71 CD44 ICAM1 NCAM1
10 T cell costimulation GO:0031295 9.7 CD28 CD40LG CTLA4
11 leukocyte cell-cell adhesion GO:0007159 9.67 CD40LG ICAM1 ITGA5
12 viral entry into host cell GO:0046718 9.63 ICAM1 ITGA2 ITGA5 ITGAV NCAM1 SELPLG
13 heterotypic cell-cell adhesion GO:0034113 9.61 ITGA5 ITGAV
14 positive regulation of collagen biosynthetic process GO:0032967 9.6 ITGA2 TGFB3
15 positive regulation of interleukin-10 production GO:0032733 9.59 CD28 CD40LG
16 positive regulation of interleukin-4 production GO:0032753 9.58 CD28 CD40LG
17 cellular response to interleukin-6 GO:0071354 9.58 ICAM1 SELPLG
18 regulation of regulatory T cell differentiation GO:0045589 9.57 CD28 CTLA4
19 cell adhesion mediated by integrin GO:0033627 9.56 ICAM1 ITGA2 ITGA5 ITGAV
20 extracellular matrix organization GO:0030198 9.56 CD44 ICAM1 ICAM2 ICAM3 ITGA1 ITGA2
21 cell-substrate adhesion GO:0031589 9.54 ITGA2 ITGA5 ITGAV
22 cell adhesion GO:0007155 9.36 CD44 CD99 ICAM1 ICAM2 ICAM3 ITGA1

Molecular functions related to Colon Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.67 ICAM3 ITGA1 ITGAV SELPLG
2 collagen binding GO:0005518 9.43 CD44 ITGA1 ITGA2
3 integrin binding GO:0005178 9.43 ICAM1 ICAM2 ICAM3 ITGA2 ITGA5 ITGAV
4 transforming growth factor beta binding GO:0050431 9.32 ITGAV TGFB3
5 collagen binding involved in cell-matrix adhesion GO:0098639 9.16 ITGA1 ITGA2
6 virus receptor activity GO:0001618 9.1 ICAM1 ITGA2 ITGA5 ITGAV NCAM1 SELPLG

Sources for Colon Carcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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