MCID: CLN004
MIFTS: 33

Colon Carcinoma in Situ

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Colon Carcinoma in Situ

MalaCards integrated aliases for Colon Carcinoma in Situ:

Name: Colon Carcinoma in Situ 12 15
Carcinoma in Situ of Colon 12
Stage 0 Carcinoma of Colon 73
Stage 0 Colonic Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8826
ICD10 33 D01.0
ICD9CM 35 230.3
SNOMED-CT 68 92568009
UMLS 73 C0154061

Summaries for Colon Carcinoma in Situ

Disease Ontology : 12 An in situ carcinoma that is located in the colon.

MalaCards based summary : Colon Carcinoma in Situ, also known as carcinoma in situ of colon, is related to middle cerebral artery infarction and cd3zeta deficiency. An important gene associated with Colon Carcinoma in Situ is TGFB3 (Transforming Growth Factor Beta 3), and among its related pathways/superpathways are Akt Signaling and Integrin Pathway. The drugs Cola and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include colon, skin and the colon, and related phenotypes are cellular and hematopoietic system

Related Diseases for Colon Carcinoma in Situ

Diseases related to Colon Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 middle cerebral artery infarction 10.1 CD40LG NCAM1
2 cd3zeta deficiency 10.1 CD44 NCAM1
3 lethal midline granuloma 10.1 ICAM1 NCAM1
4 primary thrombocytopenia 10.1 CD40LG ITGA2
5 fibrolamellar carcinoma 10.1 ITGA1 ITGAV
6 rheumatoid vasculitis 10.0 CD44 ICAM1
7 malignant skin fibrous histiocytoma 10.0 CD99 NCAM1
8 actinic prurigo 10.0 ICAM1 ICAM3
9 in situ carcinoma 9.8
10 burkitt lymphoma 9.8 CD40LG CD44 ICAM1
11 intestine carcinoma in situ 8.2 CD40LG CD44 CD99 ICAM1 ICAM2 ICAM3

Comorbidity relations with Colon Carcinoma in Situ via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Ascending Colon Cancer
Cecal Benign Neoplasm

Graphical network of the top 20 diseases related to Colon Carcinoma in Situ:



Diseases related to Colon Carcinoma in Situ

Symptoms & Phenotypes for Colon Carcinoma in Situ

MGI Mouse Phenotypes related to Colon Carcinoma in Situ:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.9 CD40LG CD44 ICAM1 ITGA1 ITGA2 ITGA5
2 hematopoietic system MP:0005397 9.61 CD40LG CD44 ICAM1 ICAM2 ITGA2 ITGAV
3 immune system MP:0005387 9.32 CD40LG CD44 ICAM1 ICAM2 ITGA1 ITGA5

Drugs & Therapeutics for Colon Carcinoma in Situ

Drugs for Colon Carcinoma in Situ (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola Phase 3,Phase 1
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3
Trastuzumab Approved, Investigational Phase 2 180288-69-1 9903
4 Angiogenesis Inhibitors Phase 2
5 Angiogenesis Modulating Agents Phase 2
6
Capecitabine Approved, Investigational Phase 1 154361-50-9 60953
7
Oxaliplatin Approved, Investigational Phase 1 61825-94-3 43805 6857599 5310940 9887054
8 Antimetabolites, Antineoplastic Phase 1
9 Antimetabolites Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Conventional Surgery Compared With Laparoscopic-Assisted Surgery in Treating Patients With Colorectal Cancer Completed NCT00003354 Phase 3
2 A Study of Avastin (Bevacizumab) Plus Herceptin (Trastuzumab) in Patients With Primary Inflammatory HER2-Positive Breast Cancer. Completed NCT00717405 Phase 2 Standard chemotherapy;bevacizumab [Avastin];trastuzumab [Herceptin]
3 Oxaliplatin Plus Capecitabine in Treating Patients With Colorectal, Appendix, or Small Bowel Cancer Completed NCT00019773 Phase 1 capecitabine;oxaliplatin

Search NIH Clinical Center for Colon Carcinoma in Situ

Genetic Tests for Colon Carcinoma in Situ

Anatomical Context for Colon Carcinoma in Situ

MalaCards organs/tissues related to Colon Carcinoma in Situ:

41
Colon, Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Colon Carcinoma in Situ:

19
The Colon

Publications for Colon Carcinoma in Situ

Articles related to Colon Carcinoma in Situ:

# Title Authors Year
1
Transcription of carcinoembryonic antigen in normal colon and colon carcinoma. In situ hybridization study and implication for a new in vivo functional model. ( 8317550 )
1993

Variations for Colon Carcinoma in Situ

Cosmic variations for Colon Carcinoma in Situ:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM43945 TP53 large intestine,colon,other,carcinoma in situ c.821T>G p.V274G 17:7673799-7673799 9
2 COSM532 KRAS large intestine,colon,other,carcinoma in situ c.38G>A p.G13D 12:25245347-25245347 9
3 COSM521 KRAS large intestine,colon,other,carcinoma in situ c.35G>A p.G12D 12:25245350-25245350 9
4 COSM522 KRAS large intestine,colon,other,carcinoma in situ c.35G>C p.G12A 12:25245350-25245350 9
5 COSM520 KRAS large intestine,colon,other,carcinoma in situ c.35G>T p.G12V 12:25245350-25245350 9

Expression for Colon Carcinoma in Situ

Search GEO for disease gene expression data for Colon Carcinoma in Situ.

Pathways for Colon Carcinoma in Situ

Pathways related to Colon Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.33 CD40LG ITGA1 ITGA2 ITGA5 ITGAV TGFB3
2
Show member pathways
13.31 CD99 ICAM1 ICAM2 ITGA1 ITGA2 ITGA5
3
Show member pathways
13.1 CD44 CD99 ITGA1 ITGA2 ITGA5 ITGAV
4
Show member pathways
12.98 ITGA1 ITGA2 ITGA5 ITGAV TGFB3
5
Show member pathways
12.86 ITGA1 ITGA2 ITGA5 ITGAV TGFB3
6
Show member pathways
12.85 CD40LG ITGA1 ITGA2 ITGA5 ITGAV
7
Show member pathways
12.81 ITGA1 ITGA2 ITGA5 ITGAV TGFB3
8
Show member pathways
12.73 ITGA1 ITGA2 ITGA5 ITGAV
9
Show member pathways
12.56 ITGA1 ITGA2 ITGA5 ITGAV
10 12.55 ITGA1 ITGA2 ITGA5 ITGAV
11
Show member pathways
12.51 CD44 ICAM1 ICAM2 ICAM3 ITGA1 ITGA2
12 12.5 CD40LG CD44 ICAM2 NCAM1
13
Show member pathways
12.37 ITGA1 ITGA2 ITGA5 ITGAV
14
Show member pathways
12.35 ITGA1 ITGA2 ITGA5 ITGAV TGFB3
15 12.25 CD44 ITGA2 ITGA5 ITGAV
16
Show member pathways
12.15 ITGA1 ITGA2 ITGA5 ITGAV
17
Show member pathways
12.13 ITGA1 ITGA2 ITGA5 ITGAV TGFB3
18 12.1 ITGA1 ITGA2 ITGA5 ITGAV
19
Show member pathways
12.1 CD99 ICAM1 ICAM2 ITGA1 ITGA2 ITGA5
20 12.06 ITGA2 ITGA5 ITGAV
21
Show member pathways
12.06 ITGA1 ITGA2 ITGA5 ITGAV
22
Show member pathways
12.05 CD44 CD99 ITGA5 ITGAV SELPLG SLC3A2
23 12.03 CD40LG ICAM1 ICAM2 ICAM3
24 11.95 CD44 ITGA2 ITGAV NCAM1
25
Show member pathways
11.93 ITGA1 ITGA2 ITGA5 ITGAV NCAM1
26 11.92 ITGA1 ITGA2 ITGA5 ITGAV
27 11.82 CD44 ITGA1 ITGA2 ITGA5
28 11.82 CD44 ICAM1 ICAM2 ITGA5 ITGAV NCAM1
29 11.8 ITGA5 ITGAV TGFB3
30 11.74 ITGA1 ITGA2 ITGA5 ITGAV
31
Show member pathways
11.73 CD44 ICAM1 ICAM2 ICAM3 ITGA1 ITGA2
32
Show member pathways
11.7 ITGA5 ITGAV TGFB3
33 11.68 ITGA1 ITGA2 ITGA5 ITGAV TGFB3
34 11.62 CD44 ITGA1 ITGA5
35 11.6 ITGA1 ITGA2 ITGA5 ITGAV
36 11.53 ITGA2 ITGAV NCAM1 TGFB3
37 11.5 CD40LG ICAM1 TGFB3
38 11.49 ITGA1 ITGA2 ITGA5 ITGAV
39 11.49 ICAM1 ICAM2 SELPLG
40 11.45 ICAM1 ICAM2 ICAM3
41 11.38 CD40LG CD99 ICAM1 ICAM2 ICAM3 ITGAV
42 11.34 CD44 ITGA2 ITGA5
43 11.34 ITGA1 ITGA2 ITGA5 ITGAV TGFB3
44 11.31 ITGA1 ITGA2 ITGA5 ITGAV
45 11.09 ITGA1 ITGA2 ITGA5
46 11.04 ICAM2 ICAM3
47 11.02 ITGA5 ITGAV NCAM1
48 10.96 CD40LG ITGA1 ITGA2 ITGA5 ITGAV TGFB3
49 10.8 ITGA1 ITGA2

GO Terms for Colon Carcinoma in Situ

Cellular components related to Colon Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.97 CD40LG CD44 CD99 ICAM1 ICAM2 ICAM3
2 plasma membrane GO:0005886 9.83 CD40LG CD44 CD99 CEACAM7 ICAM1 ICAM2
3 focal adhesion GO:0005925 9.8 CD44 CD99 ICAM1 ITGA1 ITGA2 ITGA5
4 external side of plasma membrane GO:0009897 9.7 CD40LG ICAM1 ITGA1 ITGA2 ITGA5 ITGAV
5 integrin complex GO:0008305 9.62 ITGA1 ITGA2 ITGA5 ITGAV
6 lamellipodium membrane GO:0031258 9.49 CD44 ITGAV
7 basal part of cell GO:0045178 9.48 ITGA1 ITGA2
8 uropod GO:0001931 9.46 ICAM2 SELPLG
9 cell surface GO:0009986 9.32 CD40LG CD44 ICAM1 ITGA1 ITGA2 ITGA5
10 membrane GO:0016020 10.28 CD40LG CD44 CD99 CEACAM7 ICAM1 ICAM2
11 integral component of membrane GO:0016021 10.22 CD40LG CD44 CD99 ICAM1 ICAM2 ICAM3

Biological processes related to Colon Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.88 ICAM1 ITGA2 ITGA5 ITGAV NCAM1 SELPLG
2 cell-cell adhesion GO:0098609 9.81 CD44 ICAM1 ICAM2 ICAM3
3 leukocyte migration GO:0050900 9.8 CD44 ICAM1 ITGA5 ITGAV SELPLG SLC3A2
4 cell-matrix adhesion GO:0007160 9.78 CD44 ITGA1 ITGA2 ITGAV
5 response to hypoxia GO:0001666 9.77 ICAM1 ITGA2 TGFB3
6 regulation of immune response GO:0050776 9.77 CD40LG CD99 ICAM1 ICAM2 ICAM3
7 integrin-mediated signaling pathway GO:0007229 9.76 ITGA1 ITGA2 ITGA5 ITGAV
8 female pregnancy GO:0007565 9.73 ITGA2 ITGA5 TGFB3
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.71 CD44 ICAM1 ITGA5
10 interferon-gamma-mediated signaling pathway GO:0060333 9.7 CD44 ICAM1 NCAM1
11 leukocyte cell-cell adhesion GO:0007159 9.67 CD40LG ICAM1 ITGA5
12 viral entry into host cell GO:0046718 9.63 ICAM1 ITGA2 ITGA5 ITGAV NCAM1 SELPLG
13 cell-substrate adhesion GO:0031589 9.61 ITGA2 ITGA5 ITGAV
14 endodermal cell differentiation GO:0035987 9.59 ITGA5 ITGAV
15 heterotypic cell-cell adhesion GO:0034113 9.58 ITGA5 ITGAV
16 positive regulation of collagen biosynthetic process GO:0032967 9.58 ITGA2 TGFB3
17 cellular response to interleukin-6 GO:0071354 9.57 ICAM1 SELPLG
18 cell adhesion mediated by integrin GO:0033627 9.56 ICAM1 ITGA2 ITGA5 ITGAV
19 extracellular matrix organization GO:0030198 9.56 CD44 ICAM1 ICAM2 ICAM3 ITGA1 ITGA2
20 positive regulation of SMAD protein signal transduction GO:0060391 9.55 RBPMS TGFB3
21 cell adhesion GO:0007155 9.36 CD44 CD99 ICAM1 ICAM2 ICAM3 ITGA1

Molecular functions related to Colon Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.67 ICAM3 ITGA1 ITGAV SELPLG
2 collagen binding GO:0005518 9.43 CD44 ITGA1 ITGA2
3 integrin binding GO:0005178 9.43 ICAM1 ICAM2 ICAM3 ITGA2 ITGA5 ITGAV
4 transforming growth factor beta binding GO:0050431 9.32 ITGAV TGFB3
5 collagen binding involved in cell-matrix adhesion GO:0098639 9.16 ITGA1 ITGA2
6 virus receptor activity GO:0001618 9.1 ICAM1 ITGA2 ITGA5 ITGAV NCAM1 SELPLG

Sources for Colon Carcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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