MCID: CLN011
MIFTS: 30

Colon Leiomyoma

Categories: Gastrointestinal diseases

Aliases & Classifications for Colon Leiomyoma

MalaCards integrated aliases for Colon Leiomyoma:

Name: Colon Leiomyoma 12 15 71
Colonic Leiomyoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10656
NCIt 49 C5492
UMLS 71 C1333092

Summaries for Colon Leiomyoma

MalaCards based summary : Colon Leiomyoma, also known as colonic leiomyoma, is related to leiomyoma and gastric leiomyoma. An important gene associated with Colon Leiomyoma is FGG (Fibrinogen Gamma Chain), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Developmental Biology. Affiliated tissues include colon, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Colon Leiomyoma

Diseases related to Colon Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 leiomyoma 30.6 MED12 KIT FH
2 gastric leiomyoma 29.8 KIT FH ANO1
3 smooth muscle tumor 29.7 MED12 KIT FH
4 leiomyosarcoma 29.7 MED12 KIT FH
5 small intestinal sarcoma 10.4 KIT ANO1
6 small intestine leiomyosarcoma 10.4 KIT ANO1
7 colon leiomyosarcoma 10.4 KIT ANO1
8 deep leiomyoma 10.4 KIT ANO1
9 small intestine leiomyoma 10.4 KIT ANO1
10 gastric leiomyosarcoma 10.4 KIT ANO1
11 jejunal neoplasm 10.4 KIT ANO1
12 liver leiomyoma 10.4 KIT ANO1
13 retroperitoneal leiomyosarcoma 10.4 KIT ANO1
14 liver leiomyosarcoma 10.3 KIT ANO1
15 diffuse intrinsic pontine glioma 10.3 H3-3B H3-3A
16 adult brain stem glioma 10.3 H3-3B H3-3A
17 bladder leiomyoma 10.3 KIT ANO1
18 dysfibrinogenemia, congenital 10.3 FGG FGB FGA
19 bone giant cell sarcoma 10.3 H3-3B H3-3A
20 inherited blood coagulation disease 10.3 FGG FGB FGA
21 retroperitoneal sarcoma 10.3 KIT ANO1
22 malignant giant cell tumor 10.3 H3-3B H3-3A
23 endobronchial leiomyoma 10.3 KIT ANO1
24 telangiectatic osteogenic sarcoma 10.3 H3-3B H3-3A
25 spinal cord astrocytoma 10.3 H3-3B H3-3A
26 pilocytic astrocytoma of cerebellum 10.3 H3-3B H3-3A
27 afibrinogenemia, congenital 10.3 FGG FGB FGA
28 adult oligodendroglioma 10.3 H3-3B H3-3A
29 breast malignant phyllodes tumor 10.2 MED12 KIT
30 active peptic ulcer disease 10.2 KIT ANO1
31 childhood oligodendroglioma 10.2 H3-3B H3-3A
32 clear cell chondrosarcoma 10.2 H3-3B H3-3A
33 colon sarcoma 10.2 KIT ANO1
34 childhood pilocytic astrocytoma 10.2 H3-3B H3-3A
35 chondroblastic osteosarcoma 10.2 H3-3B H3-3A
36 diffuse peritoneal leiomyomatosis 10.2 MED12 FH
37 adult astrocytic tumour 10.2 H3-3B H3-3A
38 peritoneal benign neoplasm 10.2 MED12 FH
39 benign breast phyllodes tumor 10.2 MED12 KIT
40 prostate embryonal rhabdomyosarcoma 10.2 KIT FOXO1
41 spinal cord glioma 10.2 H3-3B H3-3A
42 bizarre leiomyoma 10.1 MED12 FH
43 bladder benign neoplasm 10.1 KIT ANO1
44 leiomyoma cutis 10.1 MED12 FH
45 chondroblastoma 10.1 H3-3B H3-3A ANO1
46 brain stem cancer 10.1 H3-3B H3-3A
47 nodular malignant melanoma 10.1 KIT DIS3
48 chondroma 10.1 KIT ANO1
49 hypomelanosis of ito 10.0 KIT AKT3
50 muscle cancer 10.0 KIT FOXO1 ANO1

Graphical network of the top 20 diseases related to Colon Leiomyoma:



Diseases related to Colon Leiomyoma

Symptoms & Phenotypes for Colon Leiomyoma

MGI Mouse Phenotypes related to Colon Leiomyoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.07 AKT3 ANO1 FGA FGB FGG FOXO1
2 growth/size/body region MP:0005378 10 AKT3 ANO1 FGB FGG FOXA1 FOXO1
3 embryo MP:0005380 9.97 FGA FGB FGG FOXO1 H3-3B KIT
4 homeostasis/metabolism MP:0005376 9.93 AKT3 ANO1 FGA FGB FGG FH
5 mortality/aging MP:0010768 9.8 AKT3 ANO1 DIS3 FGA FGB FGG
6 reproductive system MP:0005389 9.23 AKT3 FGA FGB FGG FOXO1 H3-3B

Drugs & Therapeutics for Colon Leiomyoma

Search Clinical Trials , NIH Clinical Center for Colon Leiomyoma

Genetic Tests for Colon Leiomyoma

Anatomical Context for Colon Leiomyoma

MalaCards organs/tissues related to Colon Leiomyoma:

40
Colon

Publications for Colon Leiomyoma

Articles related to Colon Leiomyoma:

(show all 24)
# Title Authors PMID Year
1
Colonic Mucosubmucosal Elongated Polyp in the Sigmoid Colon on Surveillance Colonoscopy. 61
31616775 2019
2
Total laparoscopic surgery for treatment of leiomyoma of the transverse colon in a patient with an abdominal mesh: A case report. 61
31610453 2019
3
Two Cases of Leiomyoma in the Colon Masquerading as Other Types of Colonic Pedunculated Polyps. 61
29854494 2018
4
Cecal Leiomyoma: Can We Attempt Endoscopic Resection? 61
28058080 2016
5
Giant extraluminal leiomyoma of the colon: rare cause of symptomatic pelvic mass. 61
26011198 2015
6
Endoscopic Removal of Pedunculated Leiomyoma of the Sigmoid Colon. 61
26288610 2014
7
[Gastric cancer arising from gastric polyps in gardner syndrome - a case report]. 61
25731489 2014
8
A case of endoscopic resection of a colonic semipedunculated leiomyoma. 61
21980593 2011
9
Obscure-occult bleeding: resolution of unexplained chronic sideropenic anaemia by colonoscopic removal of a colonic leiomyoma. 61
22714624 2011
10
Colonic leiomyoma with huge ulceration. 61
18227569 2007
11
Endoscopic removal of pedunculated leiomyoma of the sigmoid colon (case report and literature review of dignostic and treatment options). 61
16989154 2006
12
[A case of pedunculated leiomyoma found during colonoscopic examination for anal bleeding]. 61
14978371 2004
13
Endoscopic resection of a large colonic leiomyoma. 61
11926585 2002
14
Colonic leiomyoma in a 12-year-old patient with tuberous sclerosis: a case report and brief review. 61
11396824 2001
15
Endosonographic probe-guided endoscopic removal of colonic pedunculated leiomyoma. 61
11190001 2000
16
Gastrointestinal tumors observed in nonhuman primates at the German primate center. 61
10203013 1998
17
Endoscopic removal of leiomyoma of the colon. 61
11847381 1997
18
[Hemoperitoneum caused by leiomyoma of the colon]. 61
9082239 1996
19
Gastrointestinal involvement in tuberous sclerosis. Two case reports. 61
7930433 1994
20
Endoscopic removal of colonic leiomyoma. 61
1500663 1992
21
Giant cystic leiomyoma of the sigmoid colon. 61
2009498 1991
22
Colonic leiomyoma--an unusual cause of gastrointestinal hemorrhage in childhood. Report of a case. 61
2351006 1990
23
Colonoscopic removal of a colonic leiomyoma: report of a case. 61
499727 1979
24
[An unusual case of transverse colonic leiomyoma revealed as malignant]. 61
5385929 1969

Variations for Colon Leiomyoma

Expression for Colon Leiomyoma

Search GEO for disease gene expression data for Colon Leiomyoma.

Pathways for Colon Leiomyoma

Pathways related to Colon Leiomyoma according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 H3-3B H3-3A FGG FGB FGA AKT3
2
Show member pathways
12.82 MED12 KIT H3-3B H3-3A FOXO1 FGG
3 12.62 NOTCH4 KIT FOXO1 FH AKT3
4
Show member pathways
12.56 KIT FGG FGB FGA AKT3
5
Show member pathways
12.08 H3-4 H3-3B H3-3A AKT3
6 11.93 H3-4 H3-3B H3-3A FOXO1 AKT3
7 11.9 FGG FGB FGA
8
Show member pathways
11.88 KMT2A H3-3B H3-3A
9
Show member pathways
11.85 FGG FGB FGA
10
Show member pathways
11.84 H3-4 H3-3B H3-3A
11 11.72 FGG FGB FGA AKT3
12
Show member pathways
11.68 FGG FGB FGA
13 11.63 NOTCH4 MED12 FOXO1 AKT3
14 11.34 FGG FGB FGA
15 11.3 FGG FGB FGA
16 11.29 KMT2A H3-4 H3-3B H3-3A FOXO1
17 11.06 H3-4 H3-3B H3-3A

GO Terms for Colon Leiomyoma

Cellular components related to Colon Leiomyoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 10.07 NOTCH4 MED12 KMT2A H3-4 H3-3B H3-3A
2 extracellular exosome GO:0070062 10.01 H3-4 H3-3B H3-3A FH FGG FGB
3 cell surface GO:0009986 9.85 NOTCH4 KIT FGG FGB FGA
4 external side of plasma membrane GO:0009897 9.8 KIT FGG FGB FGA
5 blood microparticle GO:0072562 9.69 FGG FGB FGA
6 nuclear chromosome, telomeric region GO:0000784 9.65 H3-4 H3-3B H3-3A
7 nucleosome GO:0000786 9.61 H3-4 H3-3B H3-3A
8 platelet alpha granule lumen GO:0031093 9.5 FGG FGB FGA
9 nuclear nucleosome GO:0000788 9.33 H3-4 H3-3B H3-3A
10 Barr body GO:0001740 9.26 H3-3B H3-3A
11 platelet alpha granule GO:0031091 9.13 FGG FGB FGA
12 fibrinogen complex GO:0005577 8.8 FGG FGB FGA

Biological processes related to Colon Leiomyoma according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.92 H3-3B H3-3A FGG FGA
2 platelet degranulation GO:0002576 9.83 FGG FGB FGA
3 nucleosome assembly GO:0006334 9.83 H3-4 H3-3B H3-3A
4 platelet activation GO:0030168 9.82 FGG FGB FGA
5 male gonad development GO:0008584 9.81 KIT H3-3B H3-3A
6 cell-matrix adhesion GO:0007160 9.81 FGG FGB FGA
7 spermatid development GO:0007286 9.8 KIT H3-3B H3-3A
8 regulation of megakaryocyte differentiation GO:0045652 9.8 KMT2A H3-3B H3-3A
9 response to calcium ion GO:0051592 9.78 FGG FGB FGA
10 hemostasis GO:0007599 9.77 FGG FGB FGA
11 positive regulation of protein secretion GO:0050714 9.77 FGG FGB FGA
12 platelet aggregation GO:0070527 9.76 FGG FGB FGA
13 toll-like receptor signaling pathway GO:0002224 9.74 FGG FGB FGA
14 positive regulation of substrate adhesion-dependent cell spreading GO:1900026 9.73 FGG FGB FGA
15 blood coagulation GO:0007596 9.72 H3-3B H3-3A FGG FGB FGA
16 negative regulation of endothelial cell apoptotic process GO:2000352 9.71 FGG FGB FGA
17 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.7 FGG FGB FGA
18 positive regulation of vasoconstriction GO:0045907 9.69 FGG FGB FGA
19 muscle cell differentiation GO:0042692 9.65 H3-3B H3-3A
20 embryonic hemopoiesis GO:0035162 9.65 KMT2A KIT
21 positive regulation of exocytosis GO:0045921 9.63 FGG FGB FGA
22 induction of bacterial agglutination GO:0043152 9.61 FGB FGA
23 cellular protein-containing complex assembly GO:0034622 9.61 FGG FGB FGA
24 pericentric heterochromatin assembly GO:0031508 9.58 H3-3B H3-3A
25 fibrinolysis GO:0042730 9.58 FGG FGB FGA
26 regulation of centromere complex assembly GO:0090230 9.55 H3-3B H3-3A
27 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.54 FGG FGB FGA
28 negative regulation of chromosome condensation GO:1902340 9.49 H3-3B H3-3A
29 telomeric heterochromatin assembly GO:0031509 9.48 H3-3B H3-3A
30 protein polymerization GO:0051258 9.43 FGG FGB FGA
31 plasminogen activation GO:0031639 9.33 FGG FGB FGA
32 positive regulation of peptide hormone secretion GO:0090277 9.13 FGG FGB FGA
33 blood coagulation, fibrin clot formation GO:0072378 8.8 FGG FGB FGA

Molecular functions related to Colon Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.86 NOTCH4 MED12 KMT2A KIT H3-4 H3-3B
2 structural molecule activity GO:0005198 9.5 FGG FGB FGA
3 extracellular matrix structural constituent GO:0005201 9.43 FGG FGB FGA
4 cell adhesion molecule binding GO:0050839 9.33 FGG FGB FGA
5 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 8.92 MED12 KMT2A H3-3B H3-3A

Sources for Colon Leiomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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