Colon Lymphoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Colon Lymphoma

MalaCards integrated aliases for Colon Lymphoma:

Name: Colon Lymphoma ¹² ¹⁵

Lymphoma of Colon ⁷³

Colonic Lymphoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Immune diseases Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:1523

NCIt ⁵⁰ C4793

SNOMED-CT ⁶⁸ 133751000119102

UMLS ⁷³ C0519037

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Summaries for Colon Lymphoma

MalaCards based summary : Colon Lymphoma, also known as lymphoma of colon, is related to lymphoma and bone lymphoma. An important gene associated with Colon Lymphoma is IRF4 (Interferon Regulatory Factor 4), and among its related pathways/superpathways are Immune response Fc epsilon RI pathway and NF-kappaB Signaling. Affiliated tissues include colon, and related phenotypes are Reduced mammosphere formation and hematopoietic system

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Related Diseases for Colon Lymphoma

Diseases related to Colon Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)

#	Related Disease	Score	Top Affiliating Genes
1	lymphoma	28.5	ALK BCL6 TNFRSF8
2	bone lymphoma	10.7	BCL6 CD22
3	primary mediastinal large b-cell lymphoma	10.7	BCL6 IRF4
4	primary effusion lymphoma	10.6	BCL6 IRF4
5	intravascular large b-cell lymphoma	10.6	BCL6 CD5
6	composite lymphoma	10.5	BCL6 CD5
7	richter's syndrome	10.5	CD5 IRF4
8	heart lymphoma	10.5	BCL6 PTPRC
9	nodular lymphocyte predominant hodgkin lymphoma	10.5	BCL6 PTPRC
10	testicular lymphoma	10.5	BCL6 PTPRC
11	posterior scleritis	10.4	CD19 CD22
12	primary cutaneous diffuse large b-cell lymphoma, leg type	10.4	CDKN2A IRF4
13	t-cell/histiocyte rich large b cell lymphoma	10.4	BCL6 TNFRSF8
14	bladder lymphoma	10.3	CD19 CD5
15	cd45 deficiency	10.3	CD5 PTPRC
16	lateral medullary syndrome	10.3	CD19 CD22
17	b cell prolymphocytic leukemia	10.3	CD19 CD5
18	marginal zone b-cell lymphoma	10.3	BCL6 CD5 IRF4
19	plasma protein metabolism disease	10.3	CD19 CD5
20	lymphoma, mucosa-associated lymphoid type	10.3	BCL6 CD5 IRF4
21	splenic marginal zone lymphoma	10.2	BCL6 CD5
22	conventional fibrosarcoma	10.2	PTPRC TNFRSF8
23	primary central nervous system lymphoma	10.2	BCL6 CDKN2A
24	testicular infarct	10.2	PTPRC TNFRSF8
25	reticulum cell sarcoma	10.2	PTPRC TNFRSF8
26	lymphosarcoma	10.2	BCL6 CD22 PTPRC
27	mediastinal malignant lymphoma	10.2	BCL6 TNFRSF8
28	gamma heavy chain disease	10.2	CD19 PTPRC
29	breast lymphoma	10.2	ALK BCL6 CD5
30	primary cutaneous anaplastic large cell lymphoma	10.1	ALK IRF4 PTPRC
31	necrotizing sialometaplasia	10.1	CD5 CDKN2A
32	reticulohistiocytic granuloma	10.1	PTPRC TNFRSF8
33	malignant fibroxanthoma	10.1	ALK PTPRC
34	plasma cell neoplasm	10.1	CD19 PTPRC
35	lymphoblastic lymphoma	10.1	BCL6 CD5 PTPRC
36	anterior scleritis	10.1	CD19 CD22 CD5
37	ecthyma	10.0	ALK TNFRSF8
38	mucinous adenocarcinoma	10.0	ALK CDKN2A
39	adult lymphoma	9.9	ALK CD5 TNFRSF8
40	mature b-cell neoplasm	9.9	BCL6 CD19 PTPRC
41	pityriasis lichenoides et varioliformis acuta	9.9	CD7 TNFRSF8
42	immune system organ benign neoplasm	9.9	CD5 PTPRC TNFRSF8
43	central nervous system lymphoma	9.9	BCL6 CDKN2A
44	thymus lipoma	9.9	CD5 PTPRC TNFRSF8
45	pityriasis lichenoides	9.8	CD7 TNFRSF8
46	hodgkin's lymphoma, lymphocytic depletion	9.8	ALK PTPRC TNFRSF8
47	rhabdomyosarcoma	9.8	ALK MSH6 PTPRC
48	anaplastic large cell lymphoma	9.8	ALK PTPRC TNFRSF8
49	plasmablastic lymphoma	9.8	BCL6 CDKN2A PTPRC
50	prolymphocytic leukemia	9.8	CD19 CD5

Graphical network of the top 20 diseases related to Colon Lymphoma:

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Symptoms & Phenotypes for Colon Lymphoma

GenomeRNAi Phenotypes related to Colon Lymphoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.02	CD5 CD7 PTPRC BCL6 CD22

MGI Mouse Phenotypes related to Colon Lymphoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.85	BCL6 CD19 CD22 CD5 CD7 CDKN2A
2	endocrine/exocrine gland	MP:0005379	9.73	ALK BCL6 CD7 CDKN2A PTPRC TNFRSF8
3	immune system	MP:0005387	9.65	BCL6 CD19 CD22 CD5 CD7 CDKN2A
4	neoplasm	MP:0002006	9.1	IRF4 MSH6 PTPRC ALK CD19 CDKN2A

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Drugs & Therapeutics for Colon Lymphoma

Search Clinical Trials , NIH Clinical Center for Colon Lymphoma

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Genetic Tests for Colon Lymphoma

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Anatomical Context for Colon Lymphoma

MalaCards organs/tissues related to Colon Lymphoma:

⁴¹

Colon

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Publications for Colon Lymphoma

Articles related to Colon Lymphoma:

#	Title	Authors	Year
1	The management of primary small bowel and colon lymphoma--a review. ( 21912877 )	Beaton C....Beynon J.	2012
2	Colon lymphoma causing intussusception. ( 22449682 )	Chien J.C....Chan W.P.	2012
3	Primary colon lymphoma in Korea: a KASID (Korean Association for the Study of Intestinal Diseases) Study. ( 16416168 )	Kim Y.H....Min Y.I.	2005
4	Unexpected detection of colon lymphoma on a Tc-99m-labeled red blood cell abdominal scan. ( 11129152 )	Sun S.S....Kao C.H.	2000
5	Colonic lymphoma producing alpha-chain disease protein. ( 6804299 )	Cho C....Smith R.	1982

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Genes for Colon Lymphoma

Genes related to Colon Lymphoma (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IRF4	Interferon Regulatory Factor 4	Protein Coding	14.82	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	CD22	CD22 Molecule	Protein Coding	14.43	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	MSH6	MutS Homolog 6	Protein Coding	14.27	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	BCL6	B Cell CLL/Lymphoma 6	Protein Coding	14.14	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	CD5	CD5 Molecule	Protein Coding	13.81	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	13.76	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	PTPRC	Protein Tyrosine Phosphatase, Receptor Type C	Protein Coding	13.67	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	CD19	CD19 Molecule	Protein Coding	13.62	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	13.22	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	CD7	CD7 Molecule	Protein Coding	4.28	DISEASES inferred ¹⁵
11	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	3.76	DISEASES inferred ¹⁵

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Variations for Colon Lymphoma

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Expression for Colon Lymphoma

Search GEO for disease gene expression data for Colon Lymphoma.

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Pathways for Colon Lymphoma

Pathways related to Colon Lymphoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Immune response Fc epsilon RI pathway ²² Show member pathways Fc epsilon RI signaling pathway ³⁷ Fc-epsilon receptor I signaling in mast cells ¹ Immune response BCR pathway ²² VEGF signaling pathway ³⁷	12.29	BCL6 CD19 CD22 PTPRC
2	NF-kappaB Signaling ⁴	12.23	BCL6 CD19 IRF4 PTPRC TNFRSF8
3	B Cell Receptor Signaling Pathway (sino) ⁶⁷ Show member pathways B Cell Receptor Signaling Pathway ⁶⁷	12	BCL6 CD19 CD22 PTPRC
4	B cell receptor signaling pathway (KEGG) ³⁷ Show member pathways B Cell Receptor Signaling Pathway ¹ BCR signaling pathway ¹	11.73	BCL6 CD19 CD22 IRF4 PTPRC
5	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.62	CD19 CD22 CD5 PTPRC
6	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.51	CD7 IRF4 PTPRC
7	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.45	CD19 IRF4 PTPRC
8	Hematopoietic cell lineage ³⁷	11.44	CD19 CD22 CD5 CD7
9	Primary immunodeficiency ³⁷	11.05	CD19 PTPRC
10	B Cell Development Pathways ⁶⁵	10.82	BCL6 CD19 CD22 CD5 PTPRC TNFRSF8

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GO Terms for Colon Lymphoma

Biological processes related to Colon Lymphoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of cell proliferation	GO:0042127	9.33	ALK BCL6 TNFRSF8
2	T cell activation	GO:0042110	9.26	CD7 IRF4
3	positive regulation of B cell proliferation	GO:0030890	8.96	BCL6 PTPRC
4	negative regulation of cell-matrix adhesion	GO:0001953	8.62	BCL6 CDKN2A

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Sources for Colon Lymphoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

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³³ ICD10

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³⁶ IUPHAR

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⁷¹ TGDB

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⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia