Colon Lymphoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Colon Lymphoma

MalaCards integrated aliases for Colon Lymphoma:

Name: Colon Lymphoma ¹² ¹⁵

Lymphoma of Colon ⁷³

Colonic Lymphoma ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Blood diseases Gastrointestinal diseases Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:1523

NCIt ⁵⁰ C4793

UMLS ⁷³ C0519037

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Summaries for Colon Lymphoma

MalaCards based summary : Colon Lymphoma, also known as lymphoma of colon, is related to bone lymphoma and primary mediastinal large b-cell lymphoma. An important gene associated with Colon Lymphoma is IRF4 (Interferon Regulatory Factor 4), and among its related pathways/superpathways are Immune response Fc epsilon RI pathway and NF-kappaB Signaling. Affiliated tissues include colon, b cells and bone, and related phenotypes are Reduced mammosphere formation and hematopoietic system

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Related Diseases for Colon Lymphoma

Diseases related to Colon Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)

#	Related Disease	Score	Top Affiliating Genes
1	bone lymphoma	10.2	BCL6 CD22
2	primary mediastinal large b-cell lymphoma	10.2	BCL6 IRF4
3	primary effusion lymphoma	10.2	BCL6 IRF4
4	intravascular large b-cell lymphoma	10.2	BCL6 CD5
5	mediastinal cancer	10.2	CD5 CD79A
6	central nervous system hematologic cancer	10.2	BCL6 IRF4
7	heart lymphoma	10.2	BCL6 PTPRC
8	composite lymphoma	10.2	BCL6 CD5
9	hodgkin's lymphoma, lymphocytic-histiocytic predominance	10.2	BCL6 PTPRC
10	testicular lymphoma	10.2	BCL6 PTPRC
11	relapsed/refractory diffuse large b-cell lymphoma	10.2	CD19 IRF4
12	selective igg deficiency disease	10.1	CD19 CD79A
13	posterior scleritis	10.1	CD19 CD22
14	richter's syndrome	10.1	CD5 IRF4
15	congenital hypogammaglobulinemia	10.1	CD19 CD79A
16	primary cutaneous diffuse large b-cell lymphoma, leg type	10.1	CDKN2A IRF4
17	solitary osseous plasmacytoma	10.1	CD19 CD79A
18	t-cell/histiocyte rich large b cell lymphoma	10.1	BCL6 TNFRSF8
19	cd45 deficiency	10.1	CD5 PTPRC
20	lateral medullary syndrome	10.1	CD19 CD22
21	breast lymphoma	10.1	BCL6 CD5 CD79A
22	plasmacytoma	10.1	CD79A IRF4 PTPRC
23	b cell prolymphocytic leukemia	10.1	CD19 CD5
24	conventional fibrosarcoma	10.1	PTPRC TNFRSF8
25	waldenstroem's macroglobulinemia	10.1	CD19 CD5
26	testicular infarct	10.1	PTPRC TNFRSF8
27	plasma protein metabolism disease	10.1	CD19 CD5
28	gamma heavy chain disease	10.1	CD19 PTPRC
29	reticulum cell sarcoma	10.1	PTPRC TNFRSF8
30	lymphoepithelioma-like thymic carcinoma	10.1	CD5 CDKN2A
31	primary cutaneous anaplastic large cell lymphoma	10.0	ALK IRF4 PTPRC
32	lymphoblastic lymphoma	10.0	BCL6 CD5 PTPRC
33	autoimmune lymphoproliferative syndrome, type v	10.0	ALK BCL6 CD5
34	reticulohistiocytic granuloma	10.0	PTPRC TNFRSF8
35	splenic marginal zone lymphoma	10.0	BCL6 CD5
36	mediastinal malignant lymphoma	10.0	BCL6 CD79A TNFRSF8
37	anterior scleritis	10.0	CD19 CD22 CD5
38	bladder lymphoma	10.0	CD19 CD5 CD79A
39	lymphoma	10.0
40	necrotizing sialometaplasia	10.0	CD5 CDKN2A
41	cryoglobulinemia	10.0	CD5 CD79A
42	plasma cell neoplasm	10.0	CD19 CD79A PTPRC
43	marginal zone b-cell lymphoma	10.0	BCL6 CD5 CD79A IRF4
44	ecthyma	10.0	ALK TNFRSF8
45	thymus lipoma	10.0	CD5 PTPRC TNFRSF8
46	immune system organ benign neoplasm	10.0	CD5 PTPRC TNFRSF8
47	adult lymphoma	10.0	ALK CD5 TNFRSF8
48	pityriasis lichenoides	10.0	CD7 TNFRSF8
49	pityriasis lichenoides et varioliformis acuta	10.0	CD7 TNFRSF8
50	transient hypogammaglobulinemia of infancy	10.0	ALK CD19

Graphical network of the top 20 diseases related to Colon Lymphoma:

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Symptoms & Phenotypes for Colon Lymphoma

GenomeRNAi Phenotypes related to Colon Lymphoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.1	BCL6 CD22 CD5 CD7 CD79A PTPRC

MGI Mouse Phenotypes related to Colon Lymphoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.9	BCL6 CD19 CD22 CD5 CD7 CD79A
2	cellular	MP:0005384	9.86	BCL6 CD19 CD22 CD79A CDKN2A IRF4
3	immune system	MP:0005387	9.7	BCL6 CD19 CD22 CD5 CD7 CD79A
4	neoplasm	MP:0002006	9.17	ALK CD19 CD79A CDKN2A IRF4 MSH6

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Drugs & Therapeutics for Colon Lymphoma

Search Clinical Trials , NIH Clinical Center for Colon Lymphoma

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Genetic Tests for Colon Lymphoma

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Anatomical Context for Colon Lymphoma

MalaCards organs/tissues related to Colon Lymphoma:

⁴¹

Colon, B Cells, Bone, Heart, T Cells, Thymus, Small Intestine

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Publications for Colon Lymphoma

Articles related to Colon Lymphoma:

(show all 11)

#	Title	Authors	Year
1	The management of primary small bowel and colon lymphoma--a review. ( 21912877 )		2012
2	Colon lymphoma causing intussusception. ( 22449682 )		2012
3	Sudden onset of renal failure requiring dialysis associated with large B-cell lymphoma of colon. ( 24475418 )	Nasri H	2012
4	Aggressive Burkitt-like lymphoma of colon in a patient with prior celiac disease. ( 17940628 )	Ahluwalia M...Saif MW	2006
5	Primary colon lymphoma in Korea: a KASID (Korean Association for the Study of Intestinal Diseases) Study. ( 16416168 )		2005
6	Mantle-cell lymphoma of colon. ( 15729249 )	Kram MT...Lo W	2005
7	Unusual abdominal tumors: case 3. Multiple lymphomatous polyposis in lymphoma of colon. ( 12610202 )	Chim CS...Liang R	2003
8	Unexpected detection of colon lymphoma on a Tc-99m-labeled red blood cell abdominal scan. ( 11129152 )	Sun S.S....Kao C.H.	2000
9	Successful nonsurgical treatment of primary mucosa-associated lymphoid tissue lymphoma of colon presenting with multiple polypoid lesions. ( 11007252 )	Auner HW...Sill H	2000
10	Primary low grade B-cell lymphoma of colon mimicking inflammatory bowel disease: a case report. ( 9294917 )	Luo JC...Lee SD	1997
11	Hodgkin's lymphoma of colon: an unusual cause of isolated splenic vein obstruction. ( 8206544 )	Seenu V...Sood S	1994

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Genes for Colon Lymphoma

Genes related to Colon Lymphoma (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IRF4	Interferon Regulatory Factor 4	Protein Coding	14.71	DISEASES inferred ¹⁵
2	CD22	CD22 Molecule	Protein Coding	14.38	DISEASES inferred ¹⁵
3	CD79A	CD79a Molecule	Protein Coding	14.33	DISEASES inferred ¹⁵
4	MSH6	MutS Homolog 6	Protein Coding	14.11	DISEASES inferred ¹⁵
5	BCL6	BCL6, Transcription Repressor	Protein Coding	14.06	DISEASES inferred ¹⁵
6	CD5	CD5 Molecule	Protein Coding	13.76	DISEASES inferred ¹⁵
7	PTPRC	Protein Tyrosine Phosphatase, Receptor Type C	Protein Coding	13.6	DISEASES inferred ¹⁵
8	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	13.57	DISEASES inferred ¹⁵
9	CD19	CD19 Molecule	Protein Coding	13.55	DISEASES inferred ¹⁵
10	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	13.07	DISEASES inferred ¹⁵
11	CD7	CD7 Molecule	Protein Coding	4.26	DISEASES inferred ¹⁵
12	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	3.71	DISEASES inferred ¹⁵

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Variations for Colon Lymphoma

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Expression for Colon Lymphoma

Search GEO for disease gene expression data for Colon Lymphoma.

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Pathways for Colon Lymphoma

Pathways related to Colon Lymphoma according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	Immune response Fc epsilon RI pathway ²² Show member pathways Fc epsilon RI signaling pathway ³⁷ Fc-epsilon receptor I signaling in mast cells ¹ Immune response BCR pathway ²² VEGF signaling pathway ³⁷	12.3	BCL6 CD19 CD22 CD79A PTPRC
2	NF-kappaB Signaling ⁴	12.25	BCL6 CD19 CD79A IRF4 PTPRC TNFRSF8
3	B Cell Receptor Signaling Pathway (sino) ⁶⁷ Show member pathways T Cell Receptor Signaling Pathway ⁶⁷	12.06	BCL6 CD19 CD22 PTPRC
4	B cell receptor signaling pathway (KEGG) ³⁷ Show member pathways B Cell Receptor Signaling Pathway ¹ BCR signaling pathway ¹	11.81	BCL6 CD19 CD22 CD79A IRF4 PTPRC
5	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers ⁶⁶ Show member pathways B-Cell Receptor Complex ⁶⁴ CD22 mediated BCR regulation ⁶⁶ CLEC7A (Dectin-1) induces NFAT activation ⁶⁶ FCERI mediated Ca+2 mobilization ⁶⁶	11.7	CD19 CD22 CD79A
6	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.62	CD19 CD22 CD5 CD79A PTPRC
7	Hematopoietic cell lineage ³⁷	11.61	CD19 CD22 CD5 CD7
8	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.56	CD7 IRF4 PTPRC
9	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.5	CD19 IRF4 PTPRC
10	Primary immunodeficiency ³⁷	11.15	CD19 CD79A PTPRC
11	B Cell Development Pathways ⁶⁵	10.82	BCL6 CD19 CD22 CD5 PTPRC TNFRSF8

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GO Terms for Colon Lymphoma

Cellular components related to Colon Lymphoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	8.92	CD19 CD5 CD79A PTPRC

Biological processes related to Colon Lymphoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of immune response	GO:0050776	9.58	BCL6 CD19 CD22
2	positive regulation of B cell proliferation	GO:0030890	9.43	BCL6 PTPRC
3	B cell receptor signaling pathway	GO:0050853	9.43	CD19 CD79A PTPRC
4	B cell proliferation	GO:0042100	9.37	CD79A PTPRC
5	negative regulation of cell-matrix adhesion	GO:0001953	9.32	BCL6 CDKN2A
6	positive regulation of interleukin-2 biosynthetic process	GO:0045086	9.16	IRF4 PTPRC
7	B cell differentiation	GO:0030183	9.13	BCL6 CD79A PTPRC
8	T cell activation	GO:0042110	8.8	CD7 IRF4 PTPRC

Molecular functions related to Colon Lymphoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane signaling receptor activity	GO:0004888	8.92	ALK CD5 CD79A TNFRSF8

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Sources for Colon Lymphoma

¹ BioSystems

² BitterDB

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⁴ Cell Signaling Technology

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⁵⁹ Orphanet

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⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

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⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia