MCID: CLN002
MIFTS: 28

Colon Mucinous Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Colon Mucinous Adenocarcinoma

MalaCards integrated aliases for Colon Mucinous Adenocarcinoma:

Name: Colon Mucinous Adenocarcinoma 12 15 17
Mucinous Adenocarcinoma of the Colon 70
Colonic Mucinous Adenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3029
NCIt 50 C7966
UMLS 70 C0279639

Summaries for Colon Mucinous Adenocarcinoma

MalaCards based summary : Colon Mucinous Adenocarcinoma, also known as mucinous adenocarcinoma of the colon, is related to mucinous adenocarcinoma and appendix adenocarcinoma, and has symptoms including constipation, fever and abdominal pain. An important gene associated with Colon Mucinous Adenocarcinoma is KDM4C (Lysine Demethylase 4C). The drugs Capecitabine and Levoleucovorin have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Colon Mucinous Adenocarcinoma

Diseases related to Colon Mucinous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 mucinous adenocarcinoma 10.3
2 appendix adenocarcinoma 10.3
3 intussusception 10.0
4 constipation 10.0
5 lynch syndrome 10.0
6 intestinal obstruction 10.0
7 adenocarcinoma 10.0
8 pseudomyxoma peritonei 10.0
9 rare tumor 10.0
10 cecum carcinoma 9.6 SNHG1 LINC01446 CLCA4
11 cecum adenocarcinoma 9.1 TCTN1 SNHG1 RARRES1 LINC01446 KDM4C CLCA4

Graphical network of the top 20 diseases related to Colon Mucinous Adenocarcinoma:



Diseases related to Colon Mucinous Adenocarcinoma

Symptoms & Phenotypes for Colon Mucinous Adenocarcinoma

UMLS symptoms related to Colon Mucinous Adenocarcinoma:


constipation; fever; abdominal pain

GenomeRNAi Phenotypes related to Colon Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-149 9.5 RARRES1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.5 TCTN1 ZG16
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.5 RARRES1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.5 RARRES1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.5 TCTN1 ZG16
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.5 RARRES1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-82 9.5 RARRES1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.5 RARRES1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.5 TCTN1 ZG16
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.5 RARRES1 TCTN1 ZG16

Drugs & Therapeutics for Colon Mucinous Adenocarcinoma

Drugs for Colon Mucinous Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
2
Levoleucovorin Approved, Investigational Phase 3 68538-85-2 149436
3
Irinotecan Approved, Investigational Phase 3 97682-44-5, 100286-90-6 60838
4
leucovorin Approved Phase 3 58-05-9 6006
5
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 5310940 9887054 6857599 43805
6
Bevacizumab Approved, Investigational Phase 3 216974-75-3
7
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
8
Edrecolomab Experimental, Investigational Phase 3 156586-89-9
9 Alkylating Agents Phase 3
10 Antibiotics, Antitubercular Phase 3
11 Mitomycins Phase 3
12 Anti-Bacterial Agents Phase 3
13 topoisomerase I inhibitors Phase 3
14 Antidotes Phase 3
15 Micronutrients Phase 3
16 Nutrients Phase 3
17 Cola Phase 3
18 Vitamin B9 Phase 3
19 Trace Elements Phase 3
20 Vitamin B Complex Phase 3
21 Folate Phase 3
22 Protective Agents Phase 3
23 Vitamins Phase 3
24 Calcium, Dietary Phase 3
25 Hormones Phase 3
26 Adjuvants, Immunologic Phase 3
27 Antineoplastic Agents, Immunological Phase 3
28 Angiogenesis Inhibitors Phase 3
29 Immunoglobulins Phase 3
30 Antibodies Phase 3
31 Immunoglobulins, Intravenous Phase 3
32 Antibodies, Monoclonal Phase 3
33 Immunoglobulin G Phase 3
34 Hematinics Phase 3
35
Calcium Nutraceutical Phase 3 7440-70-2 271
36
Panitumumab Approved, Investigational Phase 2 339177-26-3 50070211
37
ramucirumab Approved, Investigational Phase 2 947687-13-0
38
Fluorouracil Approved Phase 1, Phase 2 51-21-8 3385
39
Indomethacin Approved, Investigational Phase 1, Phase 2 53-86-1 3715
40 Fluorodeoxyglucose F18 Phase 2
41 Radiopharmaceuticals Phase 2
42 Immunosuppressive Agents Phase 1, Phase 2
43 Antimetabolites Phase 1, Phase 2
44 Immunologic Factors Phase 1, Phase 2
45 Anti-Infective Agents Phase 1, Phase 2
46 4-phenylbutyric acid Phase 1, Phase 2
47 Antirheumatic Agents Phase 1, Phase 2
48 Interferon-gamma Phase 1, Phase 2
49 Anti-Inflammatory Agents Phase 1, Phase 2
50 Tocolytic Agents Phase 1, Phase 2

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Pilot / Phase III Randomized Trial Comparing Standard Systemic Therapy to Cytoreduction + Hyperthermic Intraperitoneal Mitomycin C + Standard Systemic Therapy in Patients With Limited Peritoneal Dissemination of Colon Adenocarcinoma Unknown status NCT01167725 Phase 3 FOLFIRI regimen;FOLFOX regimen;capecitabine;fluorouracil;irinotecan hydrochloride;leucovorin calcium;mitomycin C;oxaliplatin
2 Pan-European Trials in Adjuvant Colon Cancer (PETACC-2): Randomized Phase III Intergroup Trial of High-Dose Infusional 5-FU (+ or - Folinic Acid) Versus Standard Bolus 5-FU/Folinic Acid Completed NCT00004150 Phase 3 fluorouracil;leucovorin calcium
3 A Randomized Phase III Equivalence Trial of Irinotecan (CPT-11) Versus Oxaliplatin (OXAL)/5-Fluorouracil (5-FU)/Leucovorin (CF) in Patients With Advanced Colorectal Carcinoma Previously Treated With 5-FU Completed NCT00005036 Phase 3 irinotecan hydrochloride;oxaliplatin;leucovorin calcium;fluorouracil
4 Phase III Randomized Study of Adjuvant Immunotherapy With Monoclonal Antibody 17-1A Versus No Adjuvant Therapy Following Resection for State II (Modified Astler-Coller B2) Adenocarcinoma of the Colon Completed NCT00002968 Phase 3
5 A Randomized Phase III Study Comparing 5-FU, Leucovorin and Oxaliplatin Versus 5-FU, Leucovorin, Oxaliplatin and Bevacizumab in Patients With Stage II Colon Cancer at High Risk for Recurrence to Determine Prospectively the Prognostic Value of Molecular Markers Active, not recruiting NCT00217737 Phase 3 Fluorouracil;Leucovorin Calcium;Oxaliplatin
6 A Phase II Study of the Combination of Aflibercept (VEGF-Trap) Plus Modified FOLFOX 6 in Patients With Previously Untreated Metastatic Colorectal Cancer Unknown status NCT01652196 Phase 2 oxaliplatin;leucovorin;fluorouracil
7 A Phase II Study of Panitumumab in Combination With FOLFIRI After Progression on FOLFIRI Plus Bevacizumab in KRAS(Kirsten Rat Sarcoma) and NRAS Wild-Type Metastatic Colorectal Cancer. Unknown status NCT01814501 Phase 2 irinotecan hydrochloride;fluorouracil;leucovorin calcium
8 A Phase 2 Study of MK-2206 in Previously Treated Metastatic Colorectal Cancer Patients Enriched for PTEN Loss and PIK3CA Mutation Completed NCT01802320 Phase 2 Akt Inhibitor MK2206
9 A Randomized Phase II Study of Irinotecan and Cetuximab With or Without the Anti-Angiogenic Antibody, Ramucirumab (IMC-1121B), in Advanced, K-ras Wild-Type Colorectal Cancer Following Progression on Bevacizumab-Containing Chemotherapy Active, not recruiting NCT01079780 Phase 2 irinotecan hydrochloride
10 Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate, Indomethacin and Recombinant Human Interferon-Gamma in Advanced Colorectal Cancer Terminated NCT00002796 Phase 1, Phase 2 fluorouracil;sodium phenylbutyrate;indomethacin
11 Phase II Study of Ziv-Aflibercept Followed by the Addition of 5-FU in the Third Line Setting of Metastatic Colorectal Cancer Withdrawn NCT02235324 Phase 2 leucovorin calcium;fluorouracil
12 Phase I Study of T Cells Modified With Chimeric AntiCEA Immunoglobulin-T Cell Receptors (IgTCR) in Adenocarcinoma Completed NCT00004178 Phase 1
13 Phase I Study of the Combination of Irinotecan and MLN8237 in Advanced Solid Tumors With Emphasis on Colorectal Cancer Completed NCT01923337 Phase 1 irinotecan hydrochloride;alisertib
14 A Phase I, Pharmacological, and Biological Study of OSI-774 in Combination With FOLFOX 4 (5-FU, Leucovorin, and Oxaliplatin) and Bevacizumab (Avastin) in Patients With Advanced Colorectal Cancer Completed NCT00060411 Phase 1 erlotinib hydrochloride;fluorouracil;leucovorin calcium;oxaliplatin
15 A Phase I Clinical Trial of Fluorouracil (5-FU) + CPI-613 Combination in Previously Treated Metastatic Colorectal Cancer Patients Active, not recruiting NCT02232152 Phase 1 6,8-bis(benzylthio)octanoic acid;fluorouracil
16 Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer Terminated NCT01198535 Phase 1 Gamma-Secretase Inhibitor RO4929097
17 Pilot Study Assessing the Correlation Between Telomere Length and Chemotherapy- Related Toxicity Among Early Stage and Metastatic Colorectal Patients Over the Age of 70 Terminated NCT01934179
18 Evaluation of the Effect of 25-OH-Vitamin D3 Therapy on 15-Prostaglandin Dehydrogenase Expression in Primary Tumor and Normal Colorectal Mucosa in Patients With Colorectal Cancer Withdrawn NCT01403103 Early Phase 1

Search NIH Clinical Center for Colon Mucinous Adenocarcinoma

Genetic Tests for Colon Mucinous Adenocarcinoma

Anatomical Context for Colon Mucinous Adenocarcinoma

MalaCards organs/tissues related to Colon Mucinous Adenocarcinoma:

40
Colon, T Cells, Liver, Appendix

Publications for Colon Mucinous Adenocarcinoma

Articles related to Colon Mucinous Adenocarcinoma:

(show top 50) (show all 54)
# Title Authors PMID Year
1
Treating the treatment: chemotherapy-induced multi-organ toxicity. 61
33722912 2021
2
Surgery improves the prognosis of colon mucinous adenocarcinoma with liver metastases: a SEER-based study. 61
32967651 2020
3
The Impact of Histologic Subtype on Receipt of Adjuvant Chemotherapy and Overall Survival in Stage III Colon Cancer: a Retrospective Cohort Analysis. 61
32743731 2020
4
Pseudomyxoma Peritonei Originating from Transverse Colon Mucinous Adenocarcinoma: A Case Report and Literature Review. 61
32714388 2020
5
Mucinous adenocarcinoma of the colon and rectum: A genomic analysis. 61
31729037 2019
6
The role of adjuvant chemotherapy in stage II and III mucinous colon cancer. 61
31536150 2019
7
Sequential transplantation and implications for clinical management: OLT followed by HCT and consequent RT in a pediatric patient. 61
30779289 2019
8
Carcinoma of the colon in a 40 year old female: a case report. 61
31565123 2019
9
Right-colon mucinous adenocarcinoma mimicking a hydatid cyst. 61
29313694 2018
10
Rare Case of Iliopsoas Abscess Secondary to Mucinous Adenocarcinoma of the Colon: A Case Report. 61
29854689 2018
11
[Correlation between mismatch repair proteins status and clinicopathological characteristics in sporadic colorectal cancer patients]. 61
28441855 2017
12
Primary colon adenocarcinoma with metastatic disease to the rectum followed by the left axilla. 61
28393107 2017
13
Predictive value of mucinous histology in colon cancer: a population-based, propensity score matched analysis. 61
26977857 2016
14
An unusual radiological presentation of mucinous adenocarcinoma of the colon. 61
28250979 2016
15
Squamous esophageal carcinoma and mucinous adenocarcinoma of the colon - an unusual association. 61
27151719 2016
16
Case Report of Multimodality Imaging in Omental Cake: Plain Radiograph, Computed Tomography, and Ultrasonography: A Care-Compliant Article. 61
26559303 2015
17
Diagnostic error: what Muir-Torre syndrome has taught us. 61
25795746 2015
18
Acute intestinal obstruction revealing synchronous gastrointestinal stromal tumors in a small bowel diverticulum and mucinous adenocarcinoma of the colon: a case report. 61
27053978 2015
19
Overall survival is improved in mucinous adenocarcinoma of the colon. 61
24425620 2014
20
Idiopathic phlebosclerotic colitis: a rare entity of chronic ischemic colitis. 61
24651592 2014
21
[Clinical case of the month. Chemotherapy, immunodepression and secondary neoplasms: a case report]. 61
24053102 2013
22
[A case report of advanced mucinous adenocarcinoma of the transverse colon with peritoneal dissemination effectively treated by multidisciplinary approach with a focus on FOLFOX4 therapy combined with panitumumab]. 61
22790058 2012
23
A case of colonic mucinous adenocarcinoma in 19-year-old male patient. 61
22741141 2012
24
A rare case of mucinous adenocarcinoma of the colon presenting as ileoileal intussusception in an adult. 61
22454643 2012
25
Metastatic colon cancer involving the right atrium. 61
22412235 2012
26
Anorectal mucinous adenocarcinoma in child: a case report. 61
21743985 2011
27
Mucinous adenocarcinoma of the colon - a histochemical study. 61
21892519 2011
28
Clinical outcome of signet ring cell carcinoma and mucinous adenocarcinoma of the colon. 61
20184795 2010
29
Colon mucinous adenocarcinoma in childhood: a case report with emphasis on image findings. 61
20369060 2010
30
[A case of mucinous adenocarcinoma of the colon presenting with psoas abscess]. 61
19077505 2008
31
Solid malignancies among patients in the Wegener's Granulomatosis Etanercept Trial. 61
16646004 2006
32
Malignant solid tumors associated with congenital immunodeficiency disorders. 61
15205088 2004
33
[Choice of chemotherapeutic drugs for colorectal cancers by DPD and OPRT activities in cancer tissues]. 61
15272584 2004
34
Incidence and survival of mucinous adenocarcinoma of the colorectum: a population-based study from an Asian country. 61
14719155 2004
35
[Pseudomyxoma peritonei: report of 11 cases with a literature review]. 61
12622904 2002
36
Childhood carcinoid tumors: the St Jude Children's Research Hospital experience. 61
10999679 2000
37
Heterotopic bone formation in two cases of colon carcinoma. 61
10868462 2000
38
[Umbilical metastasis of mucinous adenocarcinoma of the colon diagnosed by fine needle aspiration cytology]. 61
10686727 1999
39
Musculoskeletal case of the day. Metastatic carcinomatous arthritis from mucinous adenocarcinoma of the colon. 61
9297373 1997
40
Clinics in diagnostic imaging (22). Calcified peritoneal carcinomatosis. 61
9269371 1997
41
Antibody penetration of tumor GS-7 xenografts in nude mice: a model for mucinous adenocarcinoma of the colon. 61
8758919 1996
42
Mucin-producing tumor of the lung: CT findings. 61
7769637 1995
43
[Establishment of a human colon cancer-derived cell line (KC-1) which produces CEA, CA 19-9 and sialyl SSEA-1(SLX)]. 61
7873502 1994
44
Mucinous adenocarcinoma of the colon metastatic to the intestinal mucosa. 61
8197571 1994
45
Isolation and characterization of multiple cell types from a single human colonic carcinoma: tumourigenicity of these cell types in a xenograft system. 61
8410493 1993
46
Massive uptake of Tc-99m MDP in mucinous adenocarcinoma of the colon metastatic to liver: appearance on SPECT. 61
8391408 1993
47
[Multiple familial polyposis. Report of 4 cases and association with mucinous adenocarcinoma of the colon]. 61
2559452 1989
48
Mucinous colon carcinoma in a black family. 61
3024808 1987
49
Mucinous adenocarcinoma of the colon in a child. 61
3009625 1985
50
Accumulation of MDP in hepatic metastases from mucinous adenocarcinoma of the colon. 61
6277541 1982

Variations for Colon Mucinous Adenocarcinoma

Expression for Colon Mucinous Adenocarcinoma

Search GEO for disease gene expression data for Colon Mucinous Adenocarcinoma.

Pathways for Colon Mucinous Adenocarcinoma

GO Terms for Colon Mucinous Adenocarcinoma

Cellular components related to Colon Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of mitochondrial inner membrane GO:0031305 8.62 MPC2 MPC1

Biological processes related to Colon Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial pyruvate transmembrane transport GO:0006850 8.62 MPC2 MPC1

Molecular functions related to Colon Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyruvate transmembrane transporter activity GO:0050833 8.62 MPC2 MPC1

Sources for Colon Mucinous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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