MCID: CLN002
MIFTS: 29

Colon Mucinous Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Colon Mucinous Adenocarcinoma

MalaCards integrated aliases for Colon Mucinous Adenocarcinoma:

Name: Colon Mucinous Adenocarcinoma 12 15 17
Mucinous Adenocarcinoma of the Colon 74
Colonic Mucinous Adenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3029
NCIt 51 C7966
UMLS 74 C0279639

Summaries for Colon Mucinous Adenocarcinoma

MalaCards based summary : Colon Mucinous Adenocarcinoma, also known as mucinous adenocarcinoma of the colon, is related to mucinous adenocarcinoma and adenocarcinoma, and has symptoms including constipation, fever and abdominal pain. An important gene associated with Colon Mucinous Adenocarcinoma is SELL (Selectin L), and among its related pathways/superpathways is Keratan sulfate/keratin metabolism. The drugs Bevacizumab and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and lung.

Related Diseases for Colon Mucinous Adenocarcinoma

Diseases related to Colon Mucinous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 mucinous adenocarcinoma 10.4
2 adenocarcinoma 10.3

Symptoms & Phenotypes for Colon Mucinous Adenocarcinoma

UMLS symptoms related to Colon Mucinous Adenocarcinoma:


constipation, fever, abdominal pain

Drugs & Therapeutics for Colon Mucinous Adenocarcinoma

Drugs for Colon Mucinous Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3,Phase 2,Phase 1 216974-75-3
2
Fluorouracil Approved Phase 3,Phase 2,Phase 1 51-21-8 3385
3
Oxaliplatin Approved, Investigational Phase 3,Phase 2,Phase 1 61825-94-3 6857599 5310940 9887054 43805
4
Cetuximab Approved Phase 3,Phase 2,Phase 1,Early Phase 1 205923-56-4 56842117 2333
5
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
6
Levoleucovorin Approved, Investigational Phase 3,Phase 2,Phase 1 68538-85-2
7
leucovorin Approved Phase 3,Phase 2,Phase 1 58-05-9 6006 143
8
Irinotecan Approved, Investigational Phase 3,Phase 2,Phase 1 100286-90-6, 97682-44-5 60838
9
Calcium Approved, Nutraceutical Phase 3,Phase 2,Phase 1,Early Phase 1 7440-70-2 271
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
11 Edrecolomab Experimental, Investigational Phase 3 156586-89-9
12 Angiogenesis Inhibitors Phase 3,Phase 2,Phase 1
13 Cola Phase 3,Phase 2,Phase 1,Early Phase 1
14 Angiogenesis Modulating Agents Phase 3,Phase 2,Phase 1
15 Anti-Bacterial Agents Phase 3
16 Antidotes Phase 3,Phase 2,Phase 1
17 Antimetabolites Phase 3,Phase 2,Phase 1
18 Antineoplastic Agents, Immunological Phase 3,Phase 2,Phase 1,Early Phase 1
19 Hormones Phase 3,Phase 2,Phase 1,Early Phase 1
20 Nutrients Phase 3,Phase 2,Phase 1,Early Phase 1
21 Vitamin B Complex Phase 3,Phase 2,Phase 1
22 Trace Elements Phase 3,Phase 2,Phase 1,Early Phase 1
23 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
24 Mitomycins Phase 3
25 Vitamins Phase 3,Phase 2,Phase 1,Early Phase 1
26 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
27 Immunologic Factors Phase 3,Phase 2,Phase 1,Early Phase 1
28 Nucleic Acid Synthesis Inhibitors Phase 3
29 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
30 Alkylating Agents Phase 3
31 Antibiotics, Antitubercular Phase 3
32 Micronutrients Phase 3,Phase 2,Phase 1,Early Phase 1
33 topoisomerase I inhibitors Phase 3,Phase 2,Phase 1
34 Vitamin B9 Phase 3,Phase 2,Phase 1
35 Calcium, Dietary Phase 3,Phase 2,Phase 1,Early Phase 1
36 Folate Phase 3,Phase 2,Phase 1
37 Protective Agents Phase 3,Phase 2,Phase 1
38 Immunoglobulins Phase 3,Phase 2,Phase 1,Early Phase 1
39 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1,Early Phase 1
40 Adjuvants, Immunologic Phase 3
41 Antibodies Phase 3,Phase 2,Phase 1,Early Phase 1
42 Bone Density Conservation Agents Phase 3,Phase 2,Early Phase 1
43 Hematinics Phase 3
44 Immunoglobulin G Phase 3
45 Mitogens Phase 3,Phase 2
46 Endothelial Growth Factors Phase 3,Phase 2
47
Panitumumab Approved, Investigational Phase 2 339177-26-3 50070211
48
Ramucirumab Approved, Investigational Phase 2 947687-13-0
49
nivolumab Approved Phase 2 946414-94-4
50
Ipilimumab Approved Phase 2 477202-00-9

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Standard Therapy With or Without Surgery and Mitomycin C in Treating Patients With Advanced Limited Peritoneal Dissemination of Colon Cancer Unknown status NCT01167725 Phase 3 FOLFIRI regimen;FOLFOX regimen;capecitabine;fluorouracil;irinotecan hydrochloride;leucovorin calcium;mitomycin C;oxaliplatin
2 High-Dose Fluorouracil With or Without Leucovorin Compared With Standard Fluorouracil Plus Leucovorin Following Surgery in Treating Patients With Stage III Colon Cancer Completed NCT00004150 Phase 3 fluorouracil;leucovorin calcium
3 Edrecolomab in Treating Patients With Stage II Colon Cancer Completed NCT00002968 Phase 3
4 Irinotecan Compared With Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer Completed NCT00005036 Phase 3 irinotecan hydrochloride;oxaliplatin;leucovorin calcium;fluorouracil
5 Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer Active, not recruiting NCT00217737 Phase 3 Fluorouracil;Leucovorin Calcium;Oxaliplatin
6 Phase II Trial of FOLFOX6, Bevacizumab and Cetuximab in Patients With Colorectal Cancer Completed NCT00100841 Phase 2 oxaliplatin;leucovorin calcium;fluorouracil
7 Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery Active, not recruiting NCT01802320 Phase 2 Akt Inhibitor MK2206
8 Aflibercept and FOLFOX6 Treatment for Previously Untreated Stage IV Colorectal Cancer Active, not recruiting NCT01652196 Phase 2 oxaliplatin;leucovorin;fluorouracil
9 Panitumumab and Chemotherapy in Patients With Advanced Colorectal Cancer After Prior Therapy With Bevacizumab Active, not recruiting NCT01814501 Phase 2 irinotecan hydrochloride;fluorouracil;leucovorin calcium
10 Irinotecan Hydrochloride and Cetuximab With or Without Ramucirumab in Treating Patients With Advanced Colorectal Cancer With Progressive Disease After Treatment With Bevacizumab-Containing Chemotherapy Active, not recruiting NCT01079780 Phase 2 irinotecan hydrochloride
11 Nivolumab and Ipilimumab in Mucinous Colorectal and Appendiceal Tumors Not yet recruiting NCT03693846 Phase 2 Nivolumab;Ipilimumab
12 Chemoembolization Using Irinotecan in Treating Patients With Liver Metastases From Metastatic Colon or Rectal Cancer Terminated NCT01285102 Phase 2
13 Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer Terminated NCT00002796 Phase 1, Phase 2 fluorouracil;sodium phenylbutyrate;indomethacin
14 Gefitinib and Combination Chemotherapy in Treating Patients With Advanced or Recurrent Colorectal Cancer Terminated NCT00052585 Phase 2 irinotecan hydrochloride;gefitinib;leucovorin calcium;fluorouracil
15 Ziv-Aflibercept Followed by Ziv-Aflibercept, Fluorouracil, and Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer Withdrawn NCT02235324 Phase 2 leucovorin calcium;fluorouracil
16 Irinotecan and Alisertib in Treating Patients With Advanced Solid Tumors or Colorectal Cancer Completed NCT01923337 Phase 1 irinotecan hydrochloride;alisertib
17 A Phase I, Pharmacological, and Biological Study of OSI-774 in Combination With FOLFOX 4 (5-FU, Leucovorin, and Oxaliplatin) and Bevacizumab (Avastin) in Patients With Advanced Colorectal Cancer Completed NCT00060411 Phase 1 erlotinib hydrochloride;fluorouracil;leucovorin calcium;oxaliplatin
18 Gene Therapy in Treating Patients With Cancer Completed NCT00004178 Phase 1
19 CPI-613 and Fluorouracil in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery Recruiting NCT02232152 Phase 1 6,8-bis(benzylthio)octanoic acid;fluorouracil
20 Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies Active, not recruiting NCT01643499 Phase 1 oxaliplatin;irinotecan hydrochloride;leucovorin calcium;fluorouracil
21 Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer Terminated NCT01198535 Phase 1 Gamma-Secretase Inhibitor RO4929097
22 Irinotecan-Eluting Beads in Treating Patients With Refractory Metastatic Colon or Rectal Cancer That Has Spread to the Liver Terminated NCT02110953 Phase 1
23 Adherence to Survivorship Care Guidelines in Health Care Providers for Non-Small Cell Lung Cancer and Colorectal Cancer Survivor Care Completed NCT01726296 Not Applicable
24 Telomere Length in Predicting Toxicity in Older Patients With Stage III-IV Colorectal Cancer Undergoing Chemotherapy Terminated NCT01934179
25 Cetuximab and/or Dasatinib in Patients With Colorectal Cancer and Liver Metastases That Can Be Removed by Surgery Terminated NCT00835679 Early Phase 1 dasatinib
26 Cholecalciferol(25-[OH]-Vitamin D) in Treating Patients With Colorectal Cancer Withdrawn NCT01403103 Early Phase 1

Search NIH Clinical Center for Colon Mucinous Adenocarcinoma

Genetic Tests for Colon Mucinous Adenocarcinoma

Anatomical Context for Colon Mucinous Adenocarcinoma

MalaCards organs/tissues related to Colon Mucinous Adenocarcinoma:

42
Colon, Liver, Lung, Bone, Endothelial

Publications for Colon Mucinous Adenocarcinoma

Articles related to Colon Mucinous Adenocarcinoma:

# Title Authors Year
1
Right-colon mucinous adenocarcinoma mimicking a hydatid cyst. ( 29313694 )
2018
2
An unusual radiological presentation of mucinous adenocarcinoma of the colon. ( 28250979 )
2016
3
Acute intestinal obstruction revealing synchronous gastrointestinal stromal tumors in a small bowel diverticulum and mucinous adenocarcinoma of the colon: a case report. ( 27053978 )
2015
4
Colon mucinous adenocarcinoma in childhood: a case report with emphasis on image findings. ( 20369060 )
2010

Variations for Colon Mucinous Adenocarcinoma

Expression for Colon Mucinous Adenocarcinoma

Search GEO for disease gene expression data for Colon Mucinous Adenocarcinoma.

Pathways for Colon Mucinous Adenocarcinoma

Pathways related to Colon Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.57 CHST4 CHST5

GO Terms for Colon Mucinous Adenocarcinoma

Cellular components related to Colon Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 trans-Golgi network GO:0005802 8.96 CHST4 CHST5
2 intrinsic component of Golgi membrane GO:0031228 8.62 CHST4 CHST5

Biological processes related to Colon Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 9.26 CHST4 CHST5
2 sulfur compound metabolic process GO:0006790 9.16 CHST4 CHST5
3 N-acetylglucosamine metabolic process GO:0006044 8.96 CHST4 CHST5
4 protein sulfation GO:0006477 8.62 CHST4 CHST5

Molecular functions related to Colon Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sulfotransferase activity GO:0008146 8.96 CHST4 CHST5
2 N-acetylglucosamine 6-O-sulfotransferase activity GO:0001517 8.62 CHST4 CHST5

Sources for Colon Mucinous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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