MCID: CLN002
MIFTS: 32

Colon Mucinous Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Colon Mucinous Adenocarcinoma

MalaCards integrated aliases for Colon Mucinous Adenocarcinoma:

Name: Colon Mucinous Adenocarcinoma 12 15
Mucinous Adenocarcinoma of the Colon 73
Colonic Mucinous Adenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3029
NCIt 50 C7966
UMLS 73 C0279639

Summaries for Colon Mucinous Adenocarcinoma

MalaCards based summary : Colon Mucinous Adenocarcinoma, also known as mucinous adenocarcinoma of the colon, is related to mucinous adenocarcinoma and adenocarcinoma, and has symptoms including abdominal pain, constipation and fever. An important gene associated with Colon Mucinous Adenocarcinoma is SULT1C2 (Sulfotransferase Family 1C Member 2), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and O-linked glycosylation. The drugs Bevacizumab and Capecitabine have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and endothelial, and related phenotype is neoplasm.

Related Diseases for Colon Mucinous Adenocarcinoma

Diseases related to Colon Mucinous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 mucinous adenocarcinoma 10.3
2 adenocarcinoma 10.2

Symptoms & Phenotypes for Colon Mucinous Adenocarcinoma

UMLS symptoms related to Colon Mucinous Adenocarcinoma:


abdominal pain, constipation, fever

MGI Mouse Phenotypes related to Colon Mucinous Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.8 MUC2 SELL TMEFF2

Drugs & Therapeutics for Colon Mucinous Adenocarcinoma

Drugs for Colon Mucinous Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3,Phase 2,Phase 1 216974-75-3
2
Capecitabine Approved, Investigational Phase 3 154361-50-9 60953
3
Cetuximab Approved Phase 3,Phase 2,Phase 1,Early Phase 1 205923-56-4 56842117 2333
4
Fluorouracil Approved Phase 3,Phase 2,Phase 1 51-21-8 3385
5
Irinotecan Approved, Investigational Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
6
Levoleucovorin Approved, Investigational Phase 3,Phase 2,Phase 1 68538-85-2
7
Oxaliplatin Approved, Investigational Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
8
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
9
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1 58-05-9 143 6006
10
Camptothecin Experimental Phase 3,Phase 2,Phase 1 7689-03-4
11 Alkylating Agents Phase 3
12 Angiogenesis Inhibitors Phase 3,Phase 2,Phase 1
13 Angiogenesis Modulating Agents Phase 3,Phase 2,Phase 1
14 Anti-Bacterial Agents Phase 3
15 Antibiotics, Antitubercular Phase 3
16 Antidotes Phase 3,Phase 2,Phase 1
17 Antimetabolites Phase 3,Phase 2,Phase 1
18 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
19 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
20 Calcium, Dietary Phase 3,Phase 2,Phase 1
21 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
22 Micronutrients Phase 3,Phase 2,Phase 1,Early Phase 1
23 Mitomycins Phase 3
24 Nucleic Acid Synthesis Inhibitors Phase 3
25 Protective Agents Phase 3,Phase 2,Phase 1
26 topoisomerase I inhibitors Phase 3,Phase 2,Phase 1
27 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
28 Trace Elements Phase 3,Phase 2,Phase 1,Early Phase 1
29 Vitamin B Complex Phase 3,Phase 2,Phase 1
30 Vitamins Phase 3,Phase 2,Phase 1,Early Phase 1
31 Antibodies Phase 3,Phase 2,Phase 1,Early Phase 1
32 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1,Early Phase 1
33 Immunoglobulins Phase 3,Phase 2,Phase 1,Early Phase 1
34 Bone Density Conservation Agents Phase 3,Phase 2,Early Phase 1
35 Endothelial Growth Factors Phase 3,Phase 2
36 Hematinics Phase 3
37 Immunoglobulin G Phase 3
38 Mitogens Phase 3,Phase 2
39 Cola Nutraceutical Phase 3,Phase 2,Phase 1,Early Phase 1
40 Folate Nutraceutical Phase 3,Phase 2,Phase 1
41 Vitamin B9 Nutraceutical Phase 3,Phase 2,Phase 1
42
Ramucirumab Approved, Investigational Phase 2 947687-13-0
43
Indomethacin Approved, Investigational Phase 1, Phase 2 53-86-1 3715
44
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
45 Liver Extracts Phase 2,Phase 1,Early Phase 1
46 Protein Kinase Inhibitors Phase 2,Phase 1,Early Phase 1
47 Fluorodeoxyglucose F18 Phase 2
48 Radiopharmaceuticals Phase 2
49 4-phenylbutyric acid Phase 1, Phase 2
50 Analgesics Phase 1, Phase 2

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Standard Therapy With or Without Surgery and Mitomycin C in Treating Patients With Advanced Limited Peritoneal Dissemination of Colon Cancer Unknown status NCT01167725 Phase 3 FOLFIRI regimen;FOLFOX regimen;capecitabine;fluorouracil;irinotecan hydrochloride;leucovorin calcium;mitomycin C;oxaliplatin
2 High-Dose Fluorouracil With or Without Leucovorin Compared With Standard Fluorouracil Plus Leucovorin Following Surgery in Treating Patients With Stage III Colon Cancer Completed NCT00004150 Phase 3 fluorouracil;leucovorin calcium
3 Edrecolomab in Treating Patients With Stage II Colon Cancer Completed NCT00002968 Phase 3
4 Irinotecan Compared With Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer Completed NCT00005036 Phase 3 irinotecan hydrochloride;oxaliplatin;leucovorin calcium;fluorouracil
5 Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer Active, not recruiting NCT00217737 Phase 3 Fluorouracil;Leucovorin Calcium;Oxaliplatin
6 Phase II Trial of FOLFOX6, Bevacizumab and Cetuximab in Patients With Colorectal Cancer Completed NCT00100841 Phase 2 oxaliplatin;leucovorin calcium;fluorouracil
7 Panitumumab and Chemotherapy in Patients With Advanced Colorectal Cancer After Prior Therapy With Bevacizumab Recruiting NCT01814501 Phase 2 irinotecan hydrochloride;fluorouracil;leucovorin calcium
8 Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery Active, not recruiting NCT01802320 Phase 2 Akt Inhibitor MK2206
9 Aflibercept and FOLFOX6 Treatment for Previously Untreated Stage IV Colorectal Cancer Active, not recruiting NCT01652196 Phase 2 oxaliplatin;leucovorin;fluorouracil
10 Irinotecan Hydrochloride and Cetuximab With or Without Ramucirumab in Treating Patients With Advanced Colorectal Cancer With Progressive Disease After Treatment With Bevacizumab-Containing Chemotherapy Active, not recruiting NCT01079780 Phase 2 irinotecan hydrochloride
11 Chemoembolization Using Irinotecan in Treating Patients With Liver Metastases From Metastatic Colon or Rectal Cancer Terminated NCT01285102 Phase 2
12 Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer Terminated NCT00002796 Phase 1, Phase 2 fluorouracil;sodium phenylbutyrate;indomethacin
13 Gefitinib and Combination Chemotherapy in Treating Patients With Advanced or Recurrent Colorectal Cancer Terminated NCT00052585 Phase 2 irinotecan hydrochloride;gefitinib;leucovorin calcium;fluorouracil
14 Ziv-Aflibercept Followed by Ziv-Aflibercept, Fluorouracil, and Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer Withdrawn NCT02235324 Phase 2 leucovorin calcium;fluorouracil
15 A Phase I, Pharmacological, and Biological Study of OSI-774 in Combination With FOLFOX 4 (5-FU, Leucovorin, and Oxaliplatin) and Bevacizumab (Avastin) in Patients With Advanced Colorectal Cancer Completed NCT00060411 Phase 1 erlotinib hydrochloride;fluorouracil;leucovorin calcium;oxaliplatin
16 Gene Therapy in Treating Patients With Cancer Completed NCT00004178 Phase 1
17 CPI-613 and Fluorouracil in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery Recruiting NCT02232152 Phase 1 6,8-bis(benzylthio)octanoic acid;fluorouracil
18 Irinotecan and Alisertib in Treating Patients With Advanced Solid Tumors or Colorectal Cancer Active, not recruiting NCT01923337 Phase 1 irinotecan hydrochloride;alisertib
19 Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies Active, not recruiting NCT01643499 Phase 1 oxaliplatin;irinotecan hydrochloride;leucovorin calcium;fluorouracil
20 Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer Terminated NCT01198535 Phase 1 Gamma-Secretase Inhibitor RO4929097
21 Irinotecan-Eluting Beads in Treating Patients With Refractory Metastatic Colon or Rectal Cancer That Has Spread to the Liver Terminated NCT02110953 Phase 1
22 Adherence to Survivorship Care Guidelines in Health Care Providers for Non-Small Cell Lung Cancer and Colorectal Cancer Survivor Care Completed NCT01726296 Not Applicable
23 Telomere Length in Predicting Toxicity in Older Patients With Stage III-IV Colorectal Cancer Undergoing Chemotherapy Terminated NCT01934179
24 Cetuximab and/or Dasatinib in Patients With Colorectal Cancer and Liver Metastases That Can Be Removed by Surgery Terminated NCT00835679 Early Phase 1 dasatinib
25 Cholecalciferol(25-[OH]-Vitamin D) in Treating Patients With Colorectal Cancer Withdrawn NCT01403103 Early Phase 1

Search NIH Clinical Center for Colon Mucinous Adenocarcinoma

Genetic Tests for Colon Mucinous Adenocarcinoma

Anatomical Context for Colon Mucinous Adenocarcinoma

MalaCards organs/tissues related to Colon Mucinous Adenocarcinoma:

41
Colon, Liver, Endothelial, Lung, Bone

Publications for Colon Mucinous Adenocarcinoma

Articles related to Colon Mucinous Adenocarcinoma:

# Title Authors Year
1
Right-colon mucinous adenocarcinoma mimicking a hydatid cyst. ( 29313694 )
2018
2
Label-free imaging characteristics of colonic mucinous adenocarcinoma using multiphoton microscopy. ( 23168617 )
2013
3
A case of colonic mucinous adenocarcinoma in 19-year-old male patient. ( 22741141 )
2012
4
Colon mucinous adenocarcinoma in childhood: a case report with emphasis on image findings. ( 20369060 )
2010
5
Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma. ( 12107080 )
2002
6
Smoldering DIC associated with widespread colonic mucinous adenocarcinoma. ( 7400696 )
1980

Variations for Colon Mucinous Adenocarcinoma

Expression for Colon Mucinous Adenocarcinoma

Search GEO for disease gene expression data for Colon Mucinous Adenocarcinoma.

Pathways for Colon Mucinous Adenocarcinoma

GO Terms for Colon Mucinous Adenocarcinoma

Cellular components related to Colon Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intrinsic component of Golgi membrane GO:0031228 8.62 CHST4 CHST5

Biological processes related to Colon Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 O-glycan processing GO:0016266 9.32 CHST4 MUC2
2 keratan sulfate biosynthetic process GO:0018146 9.26 CHST4 CHST5
3 sulfur compound metabolic process GO:0006790 9.16 CHST4 CHST5
4 N-acetylglucosamine metabolic process GO:0006044 8.96 CHST4 CHST5
5 protein sulfation GO:0006477 8.62 CHST4 CHST5

Molecular functions related to Colon Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 N-acetylglucosamine 6-O-sulfotransferase activity GO:0001517 8.96 CHST4 CHST5
2 sulfotransferase activity GO:0008146 8.8 CHST4 CHST5 SULT1C2

Sources for Colon Mucinous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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