MCID: CLN014
MIFTS: 24

Colon Neuroendocrine Neoplasm

Categories: Cancer diseases, Cardiovascular diseases, Gastrointestinal diseases, Neuronal diseases

Aliases & Classifications for Colon Neuroendocrine Neoplasm

MalaCards integrated aliases for Colon Neuroendocrine Neoplasm:

Name: Colon Neuroendocrine Neoplasm 12 15 71
Colonic Neuroendocrine Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4118
NCIt 49 C5697
UMLS 71 C1333097

Summaries for Colon Neuroendocrine Neoplasm

MalaCards based summary : Colon Neuroendocrine Neoplasm, also known as colonic neuroendocrine tumor, is related to neuroendocrine carcinoma and neuroendocrine tumor. An important gene associated with Colon Neuroendocrine Neoplasm is MT-ND4 (Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 4), and among its related pathways/superpathways are Neuroscience and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. Affiliated tissues include colon and liver, and related phenotype is nervous system.

Related Diseases for Colon Neuroendocrine Neoplasm

Diseases related to Colon Neuroendocrine Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 341)
# Related Disease Score Top Affiliating Genes
1 neuroendocrine carcinoma 26.8 SYP NKX2-1 NCAM1 KRT19 ENO2 CHGA
2 neuroendocrine tumor 26.2 VIP SYP POMC NKX2-1 NCAM1 KRT19
3 neuroendocrine tumor of the colon 11.4
4 ectopic cushing syndrome 10.4 SYP POMC
5 vulva basal cell carcinoma 10.4 SYP CEACAM5
6 ovary neuroendocrine neoplasm 10.4 SYP CDX2
7 thymus basaloid carcinoma 10.4 SPINK5 NKX2-1
8 lung meningioma 10.4 SYP NKX2-1
9 bronchus adenoma 10.4 POMC NKX2-1
10 laryngeal mucoepidermoid carcinoma 10.4 CEACAM5 CDX2
11 pancreatic foamy gland adenocarcinoma 10.4 CEACAM5 CDX2
12 urinary bladder villous adenoma 10.4 CEACAM5 CDX2
13 thymus adenocarcinoma 10.4 CEACAM5 CDX2
14 vulva adenocarcinoma 10.4 CEACAM5 CDX2
15 cystitis cystica 10.4 CEACAM5 CDX2
16 mucinous intrahepatic cholangiocarcinoma 10.4 CEACAM5 CDX2
17 classic pulmonary blastoma 10.4 NKX2-1 CEACAM5
18 larynx sarcoma 10.4 NKX2-1 CEACAM5
19 anal paget's disease 10.4 CEACAM5 CDX2
20 primary hepatic neuroendocrine carcinoma 10.3 SYP CHGA
21 mucinous ovarian cystadenoma 10.3 CEACAM5 CDX2
22 descending colon cancer 10.3 CEACAM5 CDX2
23 acinar cell cystadenocarcinoma 10.3 SYP CHGA
24 cervical large cell neuroendocrine carcinoma 10.3 SYP CHGA
25 mixed ductal-endocrine carcinoma 10.3 SYP CHGA
26 duodenal gastrinoma 10.3 SPINK5 CHGA
27 breast papillary carcinoma 10.3 SYP CHGA
28 ascending colon cancer 10.3 CEACAM5 CDX2
29 ovarian mucinous neoplasm 10.3 CEACAM5 CDX2
30 linitis plastica 10.3 CEACAM5 CDX2
31 tumor of exocrine pancreas 10.3 CEACAM5 CDX2
32 lung combined type small cell carcinoma 10.3 SYP NCAM1
33 hypoganglionosis 10.3 SYP NCAM1
34 glomangiosarcoma 10.3 SYP NCAM1
35 glucagonoma 10.3 VIP CHGA
36 adult teratoma 10.3 CHGA CEACAM5
37 appendix disease 10.3 CEACAM5 CDX2
38 extra-adrenal pheochromocytoma 10.3 SYP CHGA
39 duodenum adenocarcinoma 10.3 CEACAM5 CDX2
40 mucinous bronchioloalveolar adenocarcinoma 10.3 NKX2-1 CDX2
41 orbital cellulitis 10.3 POMC NCAM1
42 acute orbital inflammation 10.3 POMC NCAM1
43 lymphangitis 10.3 NKX2-1 CEACAM5
44 gastric diffuse adenocarcinoma 10.2 CEACAM5 CDX2
45 keratinizing squamous cell carcinoma 10.2 NKX2-1 CEACAM5
46 renal pelvis adenocarcinoma 10.2 KRT19 CEACAM5
47 ovarian serous adenofibroma 10.2 POMC NCAM1
48 malignant melanocytic neoplasm of the peripheral nerve sheath 10.2 SYP ENO2
49 thymus clear cell carcinoma 10.2 NKX2-1 CDX2
50 lymphocytic hypophysitis 10.2 POMC ENO2

Graphical network of the top 20 diseases related to Colon Neuroendocrine Neoplasm:



Diseases related to Colon Neuroendocrine Neoplasm

Symptoms & Phenotypes for Colon Neuroendocrine Neoplasm

MGI Mouse Phenotypes related to Colon Neuroendocrine Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.28 CHGA CHL1 ENO2 KRT19 NCAM1 NKX2-1

Drugs & Therapeutics for Colon Neuroendocrine Neoplasm

Search Clinical Trials , NIH Clinical Center for Colon Neuroendocrine Neoplasm

Genetic Tests for Colon Neuroendocrine Neoplasm

Anatomical Context for Colon Neuroendocrine Neoplasm

MalaCards organs/tissues related to Colon Neuroendocrine Neoplasm:

40
Colon, Liver

Publications for Colon Neuroendocrine Neoplasm

Articles related to Colon Neuroendocrine Neoplasm:

# Title Authors PMID Year
1
A Perforated Colonic Neuroendocrine Tumor with Liver Metastasis: A Case Report and Literature Review. 61
31249283 2019
2
Resection of primary tumor may prolong survival in metastatic gastroenteropancreatic neuroendocrine tumors. 61
30366604 2019
3
Shared tumor antigens in colorectal carcinoma and neuroendocrine tumors. 61
9544435 1998
4
Ectopic ACTH syndrome due to colonic neuroendocrine tumor. 61
8082517 1994

Variations for Colon Neuroendocrine Neoplasm

Expression for Colon Neuroendocrine Neoplasm

Search GEO for disease gene expression data for Colon Neuroendocrine Neoplasm.

Pathways for Colon Neuroendocrine Neoplasm

Pathways related to Colon Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.7 VIP SYP POMC NKX2-1 NCAM1 ENO2
2 11.46 NCAM1 KRT19 CDX2
3 11.42 VIP PTHLH POMC CALCA

GO Terms for Colon Neuroendocrine Neoplasm

Cellular components related to Colon Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.35 VIP SYP NCAM1 CHL1 CALCA
2 extracellular region GO:0005576 9.28 VIP SPINK5 PTHLH POMC NCAM1 CHL1

Biological processes related to Colon Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.13 VIP PTHLH CALCA
2 regulation of blood pressure GO:0008217 8.8 POMC CHGA CALCA

Molecular functions related to Colon Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide hormone receptor binding GO:0051428 8.96 VIP PTHLH
2 hormone activity GO:0005179 8.92 VIP PTHLH POMC CALCA

Sources for Colon Neuroendocrine Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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