MCID: CLN018
MIFTS: 24

Colon Sarcoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Colon Sarcoma

MalaCards integrated aliases for Colon Sarcoma:

Name: Colon Sarcoma 12 15 72
Colonic Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5260
NCIt 50 C5495
UMLS 72 C1333098

Summaries for Colon Sarcoma

Disease Ontology : 12 A colon cancer that arises from transformed cells of mesenchymal origin and is located in the colon.

MalaCards based summary : Colon Sarcoma, also known as colonic sarcoma, is related to leiomyoma and lung leiomyosarcoma. An important gene associated with Colon Sarcoma is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are NF-kappaB Signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include colon, colon and prostate, and related phenotype is integument.

Related Diseases for Colon Sarcoma

Diseases related to Colon Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 leiomyoma 10.1 KIT CD34
2 lung leiomyosarcoma 10.0 KIT CD34
3 gallbladder leiomyoma 10.0 KIT CD34
4 deep leiomyoma 10.0 KIT CD34
5 extracutaneous mastocytoma 10.0 KIT CD34
6 prostate leiomyosarcoma 10.0 KIT CD34
7 gallbladder sarcoma 10.0 KIT CD34
8 sarcoma 10.0
9 spindle cell sarcoma 10.0
10 conventional fibrosarcoma 10.0 KIT CD34
11 plexiform schwannoma 10.0 KIT CD34
12 diffuse peritoneal leiomyomatosis 10.0 KIT CD34
13 peritoneal benign neoplasm 10.0 KIT CD34
14 breast angiosarcoma 10.0 KIT CD34
15 senile angioma 10.0 KIT CD34
16 angiomyoma 10.0 KIT CD34
17 spindle cell liposarcoma 10.0 KIT CD34
18 mesenchymal cell neoplasm 10.0 KIT CD34
19 benign perivascular tumor 10.0 KIT CD34
20 cardiovascular organ benign neoplasm 9.9 KIT CD34
21 muscle cancer 9.9 KIT CD34
22 vascular cancer 9.9 KIT CD34
23 neurofibroma 9.9 KIT CD34
24 connective tissue cancer 9.9 KIT CD34
25 leukocyte disease 9.9 KIT CD34
26 dermatofibrosarcoma protuberans 9.9 KIT CD34
27 gastrointestinal system cancer 9.8 KIT CD34
28 acute leukemia 9.8 KIT CD34
29 bone marrow cancer 9.8 KIT CD34
30 myelofibrosis 9.8 KIT CD34
31 gastric leiomyosarcoma 9.7 KIT ANO1
32 muscular disease 9.7 KIT CD34
33 intussusception 9.7
34 neurofibromatosis, type iv, of riccardi 9.7
35 gastric cardia carcinoma 9.7 KIT ANO1
36 ovarian brenner tumor 9.7 KIT ANO1
37 myeloma, multiple 9.7 KIT CD34
38 leukemia, acute myeloid 9.7 KIT CD34
39 leukemia, chronic myeloid 9.6 KIT CD34
40 hematologic cancer 9.4 KIT CD34
41 liver leiomyoma 9.3 KIT CD34 ANO1
42 small intestinal sarcoma 9.3 KIT CD34 ANO1
43 small intestine leiomyosarcoma 9.3 KIT CD34 ANO1
44 gastrointestinal stromal tumor 9.3 KIT CD34 ANO1

Graphical network of the top 20 diseases related to Colon Sarcoma:



Diseases related to Colon Sarcoma

Symptoms & Phenotypes for Colon Sarcoma

MGI Mouse Phenotypes related to Colon Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 8.8 ANO1 CD34 KIT

Drugs & Therapeutics for Colon Sarcoma

Search Clinical Trials , NIH Clinical Center for Colon Sarcoma

Genetic Tests for Colon Sarcoma

Anatomical Context for Colon Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Colon Sarcoma:

19
Colon

MalaCards organs/tissues related to Colon Sarcoma:

41
Colon, Prostate

Publications for Colon Sarcoma

Articles related to Colon Sarcoma:

# Title Authors PMID Year
1
Targeting DDR2 enhances tumor response to anti-PD-1 immunotherapy. 38
30801016 2019
2
Cooperative Targets of Combined mTOR/HDAC Inhibition Promote MYC Degradation. 38
28522584 2017
3
Interval based fuzzy systems for identification of important genes from microarray gene expression data: Application to carcinogenic development. 38
19591962 2009
4
Polypoid pleomorphic sarcoma of the colon. 38
16293565 2005
5
Relative contribution of normal and neoplastic cells determines telomerase activity and telomere length in primary cancers of the prostate, colon, and sarcoma. 38
9815573 1997
6
[Radiographic diagnosis of colonic sarcoma]. 38
2262998 1990
7
Colon sarcoma in the newborn. 38
490293 1979
8
[Immunogenic properties of adenocarcinoma of mouse large intestine]. 38
644968 1978
9
[An autopsy case of colon sarcoma associated with lungliver metastases and Recklinghausen's neurofibromatosis]. 38
13262353 1955

Variations for Colon Sarcoma

Expression for Colon Sarcoma

Search GEO for disease gene expression data for Colon Sarcoma.

Pathways for Colon Sarcoma

GO Terms for Colon Sarcoma

Cellular components related to Colon Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.96 KIT CD34
2 apical plasma membrane GO:0016324 8.62 CD34 ANO1

Biological processes related to Colon Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemopoiesis GO:0030097 8.62 KIT CD34

Sources for Colon Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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