MCID: CLN018
MIFTS: 30

Colon Sarcoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Colon Sarcoma

MalaCards integrated aliases for Colon Sarcoma:

Name: Colon Sarcoma 12 15 71
Colonic Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5260
NCIt 49 C5495
UMLS 71 C1333098

Summaries for Colon Sarcoma

Disease Ontology : 12 A colon cancer that arises from transformed cells of mesenchymal origin and is located in the colon.

MalaCards based summary : Colon Sarcoma, also known as colonic sarcoma, is related to intussusception and spinal cord sarcoma. An important gene associated with Colon Sarcoma is PRG2 (Proteoglycan 2, Pro Eosinophil Major Basic Protein), and among its related pathways/superpathways are NF-kappaB Signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include colon, small intestine and liver, and related phenotypes are hematopoietic system and immune system

Related Diseases for Colon Sarcoma

Diseases related to Colon Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 intussusception 29.6 KIT CD34 APOLD1 ANO1
2 spinal cord sarcoma 10.5 KIT CD34
3 gallbladder leiomyoma 10.5 KIT CD34
4 breast hemangiopericytoma 10.5 KIT CD34
5 cerebral convexity meningioma 10.5 CD34 ANO1
6 gallbladder leiomyosarcoma 10.5 KIT CD34
7 gastric leiomyoma 10.5 KIT ANO1
8 gastric leiomyosarcoma 10.5 KIT ANO1
9 heart leiomyosarcoma 10.5 KIT CD34
10 intravascular fasciitis 10.5 CD34 ANO1
11 esophagus sarcoma 10.5 KIT CD34
12 plexiform schwannoma 10.5 KIT CD34
13 retroperitoneal hemangiopericytoma 10.5 KIT CD34
14 cutaneous ganglioneuroma 10.5 KIT CD34
15 epithelioid malignant peripheral nerve sheath tumor 10.5 PRG2 CD34
16 breast malignant phyllodes tumor 10.5 KIT CD34
17 mesenchymoma 10.5 KIT CD34
18 cellular schwannoma 10.5 CD34 ANO1
19 pulmonary artery leiomyosarcoma 10.5 CD34 ANO1
20 prostate stromal sarcoma 10.4 KIT CD34
21 vagina sarcoma 10.4 KIT CD34
22 ovarian mixed germ cell neoplasm 10.4 KIT CEACAM5
23 vagina leiomyoma 10.4 CEACAM5 CD34
24 colon leiomyoma 10.4 KIT ANO1
25 breast leiomyosarcoma 10.4 KIT CD34
26 aortic malignant tumor 10.4 CEACAM5 CD34
27 esophageal adenoid cystic carcinoma 10.4 CEACAM5 ANO1
28 gliofibroma 10.4 KIT CD34
29 colonic lymphangioma 10.4 CEACAM5 CD34
30 small intestinal sarcoma 10.4 KIT CD34 ANO1
31 small intestine leiomyosarcoma 10.4 KIT CD34 ANO1
32 deep leiomyoma 10.4 KIT CD34 ANO1
33 small intestine leiomyoma 10.4 KIT CD34 ANO1
34 jejunal neoplasm 10.4 KIT CD34 ANO1
35 retroperitoneal leiomyosarcoma 10.4 KIT CD34 ANO1
36 active peptic ulcer disease 10.4 KIT ANO1
37 liver leiomyosarcoma 10.4 KIT CD34 ANO1
38 liver sarcoma 10.4 CEACAM5 CD34
39 bladder leiomyoma 10.4 KIT CD34 ANO1
40 retroperitoneal sarcoma 10.4 KIT CD34 ANO1
41 benign mesothelioma 10.4 CEACAM5 CD34
42 endobronchial leiomyoma 10.4 KIT CD34 ANO1
43 glomangiomatosis 10.4 KIT CD34
44 warthin tumor 10.4 KIT CEACAM5
45 mesenchymal cell neoplasm 10.4 KIT CD34 ANO1
46 cardiovascular cancer 10.4 KIT CD34 ANO1
47 hypervitaminosis d 10.4 CYP27B1 CYP24A1
48 conventional fibrosarcoma 10.4 KIT CD34
49 neurilemmoma 10.4 KIT CD34 ANO1
50 thyroid angiosarcoma 10.3 CEACAM5 CD34

Graphical network of the top 20 diseases related to Colon Sarcoma:



Diseases related to Colon Sarcoma

Symptoms & Phenotypes for Colon Sarcoma

MGI Mouse Phenotypes related to Colon Sarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CD34 CYP27B1 ERCC1 HCK HTR3A IBSP
2 immune system MP:0005387 9.36 CD34 CYP27B1 ERCC1 HCK HTR3A IBSP

Drugs & Therapeutics for Colon Sarcoma

Search Clinical Trials , NIH Clinical Center for Colon Sarcoma

Genetic Tests for Colon Sarcoma

Anatomical Context for Colon Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Colon Sarcoma:

19
Colon

MalaCards organs/tissues related to Colon Sarcoma:

40
Colon, Small Intestine, Liver, Breast, Prostate, Bone, Heart

Publications for Colon Sarcoma

Articles related to Colon Sarcoma:

# Title Authors PMID Year
1
Targeting DDR2 enhances tumor response to anti-PD-1 immunotherapy. 61
30801016 2019
2
Cooperative Targets of Combined mTOR/HDAC Inhibition Promote MYC Degradation. 61
28522584 2017
3
Interval based fuzzy systems for identification of important genes from microarray gene expression data: Application to carcinogenic development. 61
19591962 2009
4
Polypoid pleomorphic sarcoma of the colon. 61
16293565 2005
5
Relative contribution of normal and neoplastic cells determines telomerase activity and telomere length in primary cancers of the prostate, colon, and sarcoma. 61
9815573 1997
6
[Radiographic diagnosis of colonic sarcoma]. 61
2262998 1990
7
Colon sarcoma in the newborn. 61
490293 1979
8
[Immunogenic properties of adenocarcinoma of mouse large intestine]. 61
644968 1978
9
[An autopsy case of colon sarcoma associated with lungliver metastases and Recklinghausen's neurofibromatosis]. 61
13262353 1955

Variations for Colon Sarcoma

Expression for Colon Sarcoma

Search GEO for disease gene expression data for Colon Sarcoma.

Pathways for Colon Sarcoma

GO Terms for Colon Sarcoma

Cellular components related to Colon Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Rad51C-XRCC3 complex GO:0033065 8.62 XRCC3 RAD51C

Biological processes related to Colon Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 osteoblast differentiation GO:0001649 9.63 RUNX2 IBSP CYP24A1
2 DNA recombination GO:0006310 9.61 XRCC3 RAD51C ERCC1
3 response to vitamin D GO:0033280 9.48 CYP27B1 CYP24A1
4 hemopoiesis GO:0030097 9.43 RUNX2 KIT CD34
5 negative regulation of blood coagulation GO:0030195 9.4 PROC CD34
6 vitamin D metabolic process GO:0042359 9.37 CYP27B1 CYP24A1
7 t-circle formation GO:0090656 9.32 XRCC3 ERCC1
8 telomere maintenance via recombination GO:0000722 9.16 XRCC3 RAD51C
9 vitamin metabolic process GO:0006766 8.96 CYP27B1 CYP24A1
10 vitamin D catabolic process GO:0042369 8.62 CYP27B1 CYP24A1

Molecular functions related to Colon Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 four-way junction DNA binding GO:0000400 8.96 XRCC3 RAD51C
2 crossover junction endodeoxyribonuclease activity GO:0008821 8.62 XRCC3 RAD51C

Sources for Colon Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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