MCID: CLN009
MIFTS: 34

Colon Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Colon Squamous Cell Carcinoma

MalaCards integrated aliases for Colon Squamous Cell Carcinoma:

Name: Colon Squamous Cell Carcinoma 12 15 70
Squamous Cell Carcinoma of the Colon 58
Squamous Cell Carcinoma of Colon 12
Colonic Epidermoid Carcinoma 12

Characteristics:

Orphanet epidemiological data:

58
squamous cell carcinoma of the colon
Inheritance: Not applicable;

Classifications:

Orphanet: 58  
Rare gastroenterological diseases


External Ids:

Disease Ontology 12 DOID:5519
NCIt 50 C5490
SNOMED-CT 67 766981007
Orphanet 58 ORPHA423994
UMLS 70 C1333100

Summaries for Colon Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is located in the colon.

MalaCards based summary : Colon Squamous Cell Carcinoma, also known as squamous cell carcinoma of the colon, is related to adenocarcinoma and neuroendocrine carcinoma, and has symptoms including constipation, fever and abdominal pain. An important gene associated with Colon Squamous Cell Carcinoma is EIF3M (Eukaryotic Translation Initiation Factor 3 Subunit M), and among its related pathways/superpathways are p70S6K Signaling and RNA transport. Affiliated tissues include colon, lymph node and prostate, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Colon Squamous Cell Carcinoma

Diseases related to Colon Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 10.4
2 neuroendocrine carcinoma 10.4
3 adenosquamous carcinoma 10.2
4 adenoma 10.2
5 colorectal cancer 10.1
6 schistosoma mansoni infection, susceptibility/ 10.1
7 inflammatory bowel disease 10.1
8 colorectal adenocarcinoma 10.1
9 villous adenoma 10.1
10 large cell neuroendocrine carcinoma 10.1
11 descending colon cancer 10.1
12 schistosomiasis 10.1
13 colonic disease 10.1
14 keratinizing squamous cell carcinoma 10.1
15 adenoid squamous cell carcinoma 10.1
16 ulcerative colitis 10.1
17 esophageal cancer 10.0
18 squamous cell papilloma 10.0
19 papilloma 10.0
20 intestinal obstruction 10.0
21 dysphagia 10.0
22 rare tumor 10.0
23 squamous cell carcinoma 10.0

Graphical network of the top 20 diseases related to Colon Squamous Cell Carcinoma:



Diseases related to Colon Squamous Cell Carcinoma

Symptoms & Phenotypes for Colon Squamous Cell Carcinoma

UMLS symptoms related to Colon Squamous Cell Carcinoma:


constipation; fever; abdominal pain

GenomeRNAi Phenotypes related to Colon Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00240-S-1 9.97 EIF3C EIF3D EIF3I
2 Decreased viability GR00249-S 9.97 EIF3C EIF3D
3 Decreased viability GR00381-A-1 9.97 EIF3C EIF3D EIF3I
4 Decreased viability GR00386-A-1 9.97 EIF3C EIF3D EIF3I
5 Decreased viability GR00402-S-2 9.97 EIF3C EIF3D
6 Increased cell death in HCT116 cells GR00103-A-0 8.65 EIF3C
7 S arrest GR00098-A-2 8.62 EIF3C EIF3I

Drugs & Therapeutics for Colon Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Colon Squamous Cell Carcinoma

Genetic Tests for Colon Squamous Cell Carcinoma

Anatomical Context for Colon Squamous Cell Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Colon Squamous Cell Carcinoma:

19
Colon

MalaCards organs/tissues related to Colon Squamous Cell Carcinoma:

40
Colon, Lymph Node, Prostate

Publications for Colon Squamous Cell Carcinoma

Articles related to Colon Squamous Cell Carcinoma:

(show all 49)
# Title Authors PMID Year
1
Mixed large cell neuroendocrine carcinoma and squamous cell carcinoma of the colon: detailed molecular characterisation of two cases indicates a distinct colorectal cancer entity. 61
33197299 2021
2
Primary colonic squamous cell carcinoma: a case report and review of the literature. 61
32538102 2020
3
Squamous cell carcinoma of the colon - a case report. 61
33108883 2020
4
Metastatic Cutaneous Squamous Cell Carcinoma of the Colon Presenting as Transfusion-Dependent Hematochezia. 61
32309497 2020
5
The surprise pathology-Primary squamous cell carcinoma of the colon-A case report. 61
32516701 2020
6
Mixed neuroendocrine and squamous cell carcinoma of the colon: A case report and literature review. 61
31279236 2019
7
Mixed Neuroendocrine Carcinoma and Squamous Cell Carcinoma of the Colon: Case Report and Literature Review. 61
30022911 2018
8
Indocyanine-Green Fluorescence-GUIDED Liver Resection of Metastasis from Squamous Cell Carcinoma Invading the Biliary Tree. 61
29984013 2018
9
Gemcitabine-based chemotherapy in colon squamous cell carcinoma: A case report and literature review. 61
28413669 2017
10
[Primary squamous cell carcinoma of the colon: about a case]. 61
28904654 2017
11
Primary combined neuroendocrine carcinoma (small-cell type) and squamous cell carcinoma of the colon. 61
26212098 2016
12
SOX2 expression in gastrointestinal cancers of Iranian patients. 61
25704506 2015
13
An interesting case of primary squamous cell carcinoma of the colon with synchronous metastatic adenocarcinoma. 61
25548638 2014
14
[Primary squamous cell carcinoma of the ascending colon: report of a case and Korean literature review]. 61
25168052 2014
15
p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia. 61
23620512 2013
16
Opportunistic intestinal infections and risk of colorectal cancer among people with AIDS. 61
22149090 2012
17
[Squamous cell carcinoma of the colon. A rare histological entity]. 61
21258772 2011
18
[Primary squamous cell carcinoma of the rectum]. 61
20633345 2010
19
Metachronous squamous-cell carcinoma of the colon and treatment of rectal squamous carcinoma with chemoradiotherapy. 61
18477022 2009
20
Detection of human papillomavirus type 16 in squamous cell carcinoma of the colon and its lymph node metastases with PCR and southern blot hybridization. 61
18350376 2008
21
Squamous cell carcinoma of the rectum: a case report and review of the literature. 61
15698388 2005
22
Primary squamous cell carcinoma of the colon associated with hypercalcemia and hyperleukocytosis. Report of a case. 61
16424667 2005
23
Does human papilloma virus have a role in squamous cell carcinoma of the colon and upper rectum? 61
12359204 2002
24
Squamous cell carcinoma of the colon with an elevated serum squamous cell carcinoma antigen responding to combination chemotherapy. 61
12445380 2001
25
Squamous cell carcinoma of the colon in an asbestos worker. 61
10556012 1999
26
Squamous-cell carcinoma of the colon responsive to combination chemotherapy: report of two cases and review of the literature. 61
10211528 1999
27
Metastatic carcinoma to the male and female breast. 61
9509597 1998
28
Squamous cell carcinoma complicating idiopathic inflammatory bowel disease. 61
7745978 1995
29
Primary squamous-cell carcinoma of the colon: a case report. 61
7846991 1994
30
Squamous cell carcinoma of the splenic flexure of the colon: report of a case. 61
8054782 1994
31
[Squamous cell carcinoma of the colon. A case report]. 61
1340840 1992
32
Primary adenosquamous and squamous cell carcinoma of the colon and rectum. 61
1402312 1992
33
Adenosquamous carcinoma of the colon--an immunocytochemical and ultrastructural study. Report of two cases and review of the literature. 61
2666053 1989
34
Primary squamous cell carcinoma of the colon arising in a villous adenoma. 61
3278968 1988
35
Squamous-cell carcinoma of the colon. Experience at the University of Chicago, review of the literature, report of two cases. 61
3280272 1988
36
[Squamous cell carcinoma of the ascending colon--a case report and review of literature]. 61
3315530 1987
37
Squamous cell carcinoma of the colon and rectum. 61
3775628 1986
38
Squamous cell carcinoma of the cecum. 61
4038062 1985
39
Squamous cell carcinoma of the splenic flexure of the colon. 61
6352206 1983
40
Squamous-cell carcinoma of the colon and rectum. 61
6825528 1983
41
[Squamous epithelial carcinoma in a sigmoid diverticulum. Case report and review of the literature]. 61
7116992 1982
42
Squamous cell carcinoma arising in a duplication of the colon: case report and literature review of squamous cell carcinoma of the colon and of malignancy complicating colonic duplication. 61
7226009 1981
43
Squamous cell carcinoma of the ascending colon. 61
532800 1979
44
Production and characterization of xenogeneic antisera to a human renal cell carcinoma-associated antigen. 61
88535 1979
45
Squamous-cell carcinoma of the proximal colon: report of a case and review of the literature. 61
467177 1979
46
Squamous cell carcinoma of the cecum: a case report. 61
361214 1978
47
[4 malignant colo-rectal and peritoneal tumors appearing after pelvic irradiation]. 61
659223 1978
48
Adenosquamous and squamous cell carcinoma of the colon. 61
637188 1978
49
Squamous-cell carcinoma of the colon and rectum: report of a case. 61
6066367 1967

Variations for Colon Squamous Cell Carcinoma

Expression for Colon Squamous Cell Carcinoma

Search GEO for disease gene expression data for Colon Squamous Cell Carcinoma.

Pathways for Colon Squamous Cell Carcinoma

Pathways related to Colon Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.32 EIF3I EIF3D EIF3C
2 11.6 EIF3I EIF3D EIF3C
3
Show member pathways
11.3 EIF3M EIF3I EIF3D EIF3C
4
Show member pathways
10.92 EIF3I EIF3D EIF3C

GO Terms for Colon Squamous Cell Carcinoma

Cellular components related to Colon Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 eukaryotic 43S preinitiation complex GO:0016282 9.46 EIF3M EIF3I EIF3D EIF3C
2 eukaryotic translation initiation factor 3 complex, eIF3m GO:0071541 9.43 EIF3M EIF3I EIF3D
3 eukaryotic translation initiation factor 3 complex GO:0005852 9.26 EIF3M EIF3I EIF3D EIF3C
4 eukaryotic 48S preinitiation complex GO:0033290 8.92 EIF3M EIF3I EIF3D EIF3C

Biological processes related to Colon Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 translation GO:0006412 9.56 EIF3M EIF3I EIF3D EIF3C
2 translational initiation GO:0006413 9.46 EIF3M EIF3I EIF3D EIF3C
3 positive regulation of translation GO:0045727 9.4 EIF3D EIF3C
4 positive regulation of fibroblast apoptotic process GO:2000271 9.37 STK17B STK17A
5 positive regulation of mRNA binding GO:1902416 9.32 EIF3D EIF3C
6 cytoplasmic translational initiation GO:0002183 9.26 EIF3M EIF3I EIF3D EIF3C
7 formation of cytoplasmic translation initiation complex GO:0001732 8.92 EIF3M EIF3I EIF3D EIF3C

Molecular functions related to Colon Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 translation initiation factor binding GO:0031369 8.96 EIF3M EIF3C
2 translation initiation factor activity GO:0003743 8.92 EIF3M EIF3I EIF3D EIF3C

Sources for Colon Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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