MCID: CLN009
MIFTS: 31

Colon Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Colon Squamous Cell Carcinoma

MalaCards integrated aliases for Colon Squamous Cell Carcinoma:

Name: Colon Squamous Cell Carcinoma 12 15 73
Squamous Cell Carcinoma of the Colon 59
Squamous Cell Carcinoma of Colon 12
Colonic Epidermoid Carcinoma 12

Characteristics:

Orphanet epidemiological data:

59
squamous cell carcinoma of the colon
Inheritance: Not applicable;

Classifications:



External Ids:

Disease Ontology 12 DOID:5519
NCIt 50 C5490
Orphanet 59 ORPHA423994
UMLS 73 C1333100

Summaries for Colon Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is located in the colon.

MalaCards based summary : Colon Squamous Cell Carcinoma, also known as squamous cell carcinoma of the colon, is related to squamous cell carcinoma and villous adenoma, and has symptoms including constipation, fever and abdominal pain. An important gene associated with Colon Squamous Cell Carcinoma is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase). Affiliated tissues include colon, skin and lung, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Colon Squamous Cell Carcinoma

Diseases related to Colon Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 30.0 BRAF WWOX
2 villous adenoma 9.9
3 papilloma 9.9
4 adenocarcinoma 9.9
5 adenoma 9.9
6 diabetic foot ulcers 9.9
7 adamantinoma of long bones 9.8 BRAF SOX2
8 lung squamous cell carcinoma 9.8 BRAF SOX2
9 large intestine cancer 9.7 BRAF SOX2
10 brain cancer 9.6 BRAF SOX2

Graphical network of the top 20 diseases related to Colon Squamous Cell Carcinoma:



Diseases related to Colon Squamous Cell Carcinoma

Symptoms & Phenotypes for Colon Squamous Cell Carcinoma

UMLS symptoms related to Colon Squamous Cell Carcinoma:


constipation, fever, abdominal pain

GenomeRNAi Phenotypes related to Colon Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.23 BRAF
2 Decreased viability GR00221-A-1 9.23 SOX2
3 Decreased viability GR00221-A-4 9.23 BRAF SOX2
4 Decreased viability GR00301-A 9.23 BRAF
5 Decreased viability GR00381-A-1 9.23 BRAF
6 Decreased viability GR00402-S-2 9.23 BRAF SOX2

MGI Mouse Phenotypes related to Colon Squamous Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.43 BRAF SOX2 WWOX
2 neoplasm MP:0002006 9.33 BRAF SOX2 WWOX
3 reproductive system MP:0005389 9.13 BRAF SOX2 WWOX
4 skeleton MP:0005390 8.8 BRAF SOX2 WWOX

Drugs & Therapeutics for Colon Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Colon Squamous Cell Carcinoma

Genetic Tests for Colon Squamous Cell Carcinoma

Anatomical Context for Colon Squamous Cell Carcinoma

MalaCards organs/tissues related to Colon Squamous Cell Carcinoma:

41
Colon, Skin, Lung, Brain, Bone, Lymph Node

The Foundational Model of Anatomy Ontology organs/tissues related to Colon Squamous Cell Carcinoma:

19
The Colon

Publications for Colon Squamous Cell Carcinoma

Articles related to Colon Squamous Cell Carcinoma:

(show all 20)
# Title Authors Year
1
Mixed Neuroendocrine Carcinoma and Squamous Cell Carcinoma of the Colon: Case Report and Literature Review. ( 30022911 )
2018
2
Gemcitabine-based chemotherapy in colon squamous cell carcinoma: A case report and literature review. ( 28413669 )
2017
3
Primary combined neuroendocrine carcinoma (small-cell type) and squamous cell carcinoma of the colon. ( 26212098 )
2016
4
An interesting case of primary squamous cell carcinoma of the colon with synchronous metastatic adenocarcinoma. ( 25548638 )
2014
5
Metachronous squamous-cell carcinoma of the colon and treatment of rectal squamous carcinoma with chemoradiotherapy. ( 18477022 )
2009
6
Detection of human papillomavirus type 16 in squamous cell carcinoma of the colon and its lymph node metastases with PCR and southern blot hybridization. ( 18350376 )
2008
7
Primary squamous cell carcinoma of the colon associated with hypercalcemia and hyperleukocytosis. Report of a case. ( 16424667 )
2005
8
Does human papilloma virus have a role in squamous cell carcinoma of the colon and upper rectum? ( 12359204 )
2002
9
Squamous cell carcinoma of the colon with an elevated serum squamous cell carcinoma antigen responding to combination chemotherapy. ( 12445380 )
2001
10
Squamous-cell carcinoma of the colon responsive to combination chemotherapy: report of two cases and review of the literature. ( 10211528 )
1999
11
Squamous cell carcinoma of the colon in an asbestos worker. ( 10556012 )
1999
12
Primary squamous-cell carcinoma of the colon: a case report. ( 7846991 )
1994
13
Primary adenosquamous and squamous cell carcinoma of the colon and rectum. ( 1402312 )
1992
14
Primary squamous cell carcinoma of the colon arising in a villous adenoma. ( 3278968 )
1988
15
Squamous-cell carcinoma of the colon. Experience at the University of Chicago, review of the literature, report of two cases. ( 3280272 )
1988
16
Squamous cell carcinoma of the colon and rectum. ( 3775628 )
1986
17
Squamous-cell carcinoma of the colon and rectum. ( 6825528 )
1983
18
Squamous cell carcinoma arising in a duplication of the colon: case report and literature review of squamous cell carcinoma of the colon and of malignancy complicating colonic duplication. ( 7226009 )
1981
19
Adenosquamous and squamous cell carcinoma of the colon. ( 637188 )
1978
20
Squamous-cell carcinoma of the colon and rectum: report of a case. ( 6066367 )
1967

Variations for Colon Squamous Cell Carcinoma

Expression for Colon Squamous Cell Carcinoma

Search GEO for disease gene expression data for Colon Squamous Cell Carcinoma.

Pathways for Colon Squamous Cell Carcinoma

GO Terms for Colon Squamous Cell Carcinoma

Biological processes related to Colon Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 osteoblast differentiation GO:0001649 8.96 SOX2 WWOX
2 somatic stem cell population maintenance GO:0035019 8.62 BRAF SOX2

Sources for Colon Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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