MCID: CLN045
MIFTS: 43

Colonic Benign Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Colonic Benign Neoplasm

MalaCards integrated aliases for Colonic Benign Neoplasm:

Name: Colonic Benign Neoplasm 12 15
Neoplasm of the Colon 29 6
Neoplasm of Colon 12
Colonic Neoplasms 73
Colon Neoplasm 12
Colonic Tumor 12
Colonic Mass 12

Classifications:



External Ids:

Disease Ontology 12 DOID:235
MeSH 44 D003110
NCIt 50 C2953
SNOMED-CT 68 126838000
ICD10 33 C18
UMLS 73 C0009375

Summaries for Colonic Benign Neoplasm

Disease Ontology : 12 An intestinal benign neoplasm that is located in the colon.

MalaCards based summary : Colonic Benign Neoplasm, also known as neoplasm of the colon, is related to sigmoid neoplasm and familial adenomatous polyposis. An important gene associated with Colonic Benign Neoplasm is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are Development HGF signaling pathway and Development EGFR signaling pathway. Affiliated tissues include the colon, colon and heart, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Colonic Benign Neoplasm

Diseases related to Colonic Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 sigmoid neoplasm 32.0 CEACAM5 KRAS
2 familial adenomatous polyposis 29.9 CTNNB1 KRAS PTGS2
3 adenoma 29.5 BRAF CTNNB1 KRAS PTGS2
4 adenocarcinoma 29.5 BRAF CTNNB1 KRAS PTGS2
5 lung cancer susceptibility 3 28.6 BRAF CEACAM5 CTNNB1 KRAS PTGS2
6 colorectal cancer 11.6
7 colon adenoma 11.0
8 neuroendocrine tumor of the colon 11.0
9 papillary craniopharyngioma 10.7 BRAF CTNNB1
10 hyperplastic polyposis syndrome 10.7 BRAF KRAS
11 syringocystadenoma papilliferum 10.6 BRAF KRAS
12 mature teratoma 10.6 BRAF KRAS
13 villous adenoma 10.5 BRAF KRAS
14 small intestinal adenocarcinoma 10.5 BRAF CTNNB1 KRAS
15 apocrine adenoma 10.4 CEACAM5 KRAS
16 clear cell adenoma 10.4 CEACAM5 CTNNB1
17 skin melanoma 10.4 BRAF CTNNB1 PTGS2
18 colorectal adenoma 10.4 CTNNB1 KRAS PTGS2
19 bladder urothelial carcinoma 10.4 BRAF CTNNB1 KRAS
20 aggressive digital papillary adenocarcinoma 10.4 CEACAM5 KRAS
21 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.3 CTNNB1 KRAS
22 lynch syndrome 10.3 BRAF CTNNB1 KRAS
23 ovary serous adenocarcinoma 10.3 CEACAM5 KRAS
24 colon squamous cell carcinoma 10.2
25 ovarian cystadenocarcinoma 10.2 CEACAM5 KRAS
26 cell type benign neoplasm 10.2 CEACAM5 CTNNB1 KRAS
27 familial colorectal cancer type x 10.2
28 biliary papillomatosis 10.2 CEACAM5 KRAS
29 pancreatic cystadenocarcinoma 10.0 CEACAM5 KRAS
30 squamous cell carcinoma 10.0 BRAF CTNNB1 KRAS PTGS2
31 ovarian cancer 1 10.0 AREG CEACAM5 KRAS
32 wilms tumor 1 10.0 AREG CTNNB1 KRAS
33 malignant ovarian surface epithelial-stromal neoplasm 10.0 AREG CEACAM5 KRAS
34 ovary epithelial cancer 10.0 AREG CEACAM5 KRAS
35 squamous cell carcinoma, head and neck 10.0 AREG BRAF CTNNB1 PTGS2
36 endocrine gland cancer 10.0 AREG CEACAM5 KRAS
37 colitis 9.9
38 ovary adenocarcinoma 9.9 CEACAM5 KRAS
39 colon adenocarcinoma 9.9 CEACAM5 CTNNB1 KRAS PTGS2
40 ulcerative colitis 9.8
41 cholangiocarcinoma 9.8 CEACAM5 CTNNB1 KRAS PTGS2
42 female reproductive organ cancer 9.7 AREG CEACAM5 CTNNB1 KRAS
43 respiratory system cancer 9.7 AREG CEACAM5 CTNNB1 KRAS
44 cell type cancer 9.7 AREG CEACAM5 CTNNB1 KRAS
45 thyroid cancer 9.7 BRAF CEACAM5 CTNNB1 KRAS
46 cholangitis, primary sclerosing 9.7
47 inflammatory bowel disease 9.7
48 sclerosing cholangitis 9.7
49 cholangitis 9.7
50 pancreas adenocarcinoma 9.7 AREG CEACAM5 CTNNB1 KRAS

Graphical network of the top 20 diseases related to Colonic Benign Neoplasm:



Diseases related to Colonic Benign Neoplasm

Symptoms & Phenotypes for Colonic Benign Neoplasm

MGI Mouse Phenotypes related to Colonic Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.43 AREG BRAF CTNNB1 KRAS LGR5 PTGS2
2 endocrine/exocrine gland MP:0005379 9.23 AREG BRAF CTNNB1 HPGD KRAS LGR5

Drugs & Therapeutics for Colonic Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Colonic Benign Neoplasm

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Colonic Benign Neoplasm

Genetic tests related to Colonic Benign Neoplasm:

# Genetic test Affiliating Genes
1 Neoplasm of the Colon 29

Anatomical Context for Colonic Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Colonic Benign Neoplasm:

19
The Colon

MalaCards organs/tissues related to Colonic Benign Neoplasm:

41
Colon, Heart, Appendix, Spinal Cord

Publications for Colonic Benign Neoplasm

Articles related to Colonic Benign Neoplasm:

(show all 41)
# Title Authors Year
1
[The expression of claudins in colonic neoplasms]. ( 28295005 )
2017
2
Helicobacter pylori Infection with Atrophic Gastritis Is an Independent Risk Factor for Advanced Colonic Neoplasm. ( 27458180 )
2016
3
DNA Methylation and Mutation of Small Colonic Neoplasms in Ulcerative Colitis and Crohn's Colitis: Implications for Surveillance. ( 27104828 )
2016
4
Temporal trends in colon neoplasms in patients with primary sclerosing cholangitis and ulcerative colitis. ( 22398080 )
2012
5
Single-incision versus conventional laparoscopic colectomy for colonic neoplasm: a randomized, controlled trial. ( 22538676 )
2012
6
Expression of EGFR, HER2, phosphorylated ERK and phosphorylated MEK in colonic neoplasms of familial adenomatous polyposis patients. ( 21989899 )
2012
7
Colon neoplasms develop early in the course of inflammatory bowel disease and primary sclerosing cholangitis. ( 20920596 )
2011
8
Colonic neoplasm in a strangulated inguinal hernia. ( 20524766 )
2010
9
Endoscopic resection of giant lipoma mimicking colonic neoplasm initially presenting with massive haemorrhage: a case report. ( 20181161 )
2009
10
Cellular expression patterns of genes upregulated in murine and human colonic neoplasms. ( 18180384 )
2008
11
The association of fasting insulin concentrations and colonic neoplasms in acromegaly: a colonoscopy-based study in 210 patients. ( 17652220 )
2007
12
Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc(Min/+) mice: inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms. ( 16049979 )
2006
13
Colonic epithelial cell expression of ICAM-1 relates to loss of surface continuity: a comparative study of inflammatory bowel disease and colonic neoplasms. ( 16497620 )
2006
14
Immunohistochemical analysis of morules in colonic neoplasms: morules are morphologically and qualitatively different from squamous metaplasia. ( 16374071 )
2005
15
Low frequency of bcl-2 expression in large non-polypoid colonic neoplasms. ( 15303767 )
2004
16
Magnetic resonance colonography in the detection of colonic neoplasm in high-risk and average-risk individuals. ( 14687150 )
2004
17
Risk of renal and colonic neoplasms and spontaneous pneumothorax in the Birt-Hogg-DubAc syndrome. ( 11927500 )
2002
18
Expression of ets-1 and ets-2 in colonic neoplasms. ( 12168840 )
2002
19
Development of colonic neoplasms and expressions of p53 and p21 proteins in experimental colitis of mice induced by dextran sulfate sodium. ( 11718223 )
2001
20
Bimodal expression of heparin-binding EGF-like growth factor in colonic neoplasms. ( 11396220 )
2001
21
Decreased expression of CD44, alpha-catenin, and deleted colon carcinoma and altered expression of beta-catenin in ulcerative colitis-associated dysplasia and carcinoma, as compared with sporadic colon neoplasms. ( 10951334 )
2000
22
Colonic neoplasm in asymptomatic patients with family history of colon cancer: results of a colonoscopic prospective and controlled study. Results of a pilot study of endoscopic screening of first degree relatives of colorectal cancer patients in Italy. ( 10048957 )
1999
23
[The relationship between the histopathological atypia and expression of beta-catenin in colonic neoplasms resected by endoscopy; comparison with that of p53 protein]. ( 10513218 )
1999
24
Effects of intestinal bacteria on the development of colonic neoplasm: an experimental study. ( 10443953 )
1999
25
Effects of intestinal bacteria on the development of colonic neoplasm II. Changes in the immunological environment. ( 10643943 )
1999
26
An epitope localized in c-Src negative regulatory domain is a potential marker in early stage of colonic neoplasms. ( 9484720 )
1998
27
Cytomegalovirus colitis mimicking a colonic neoplasm or ischemic colitis 4 years after heart transplantation. ( 9869101 )
1998
28
Polymerase chain reaction-based approaches for detection of allelic loss in the p53 tumor suppressor gene in colon neoplasms. ( 9040212 )
1997
29
Endoscopic abnormalities of the anastomosis following resection of colonic neoplasm. ( 7988818 )
1994
30
Induction of nm23 gene expression in human colonic neoplasms and equal expression in colon tumors of high and low metastatic potential. ( 2023273 )
1991
31
Immunohistochemical localization of sodium-potassium-stimulated adenosine triphosphatase and carbonic anhydrase in human colon and colonic neoplasms. ( 1690978 )
1990
32
The Muir-Torre syndrome: a disease of sebaceous and colonic neoplasms. ( 2917677 )
1989
33
Benign colonic neoplasm at the site of ureterosigmoidostomy. ( 3780806 )
1986
34
Turcot syndrome: a case with spinal cord and colonic neoplasms. ( 6320614 )
1984
35
Cecal fecaloma mimicking colonic neoplasm. ( 7307862 )
1981
36
S. bovis endocarditis on a prosthetic heart valve, with a colonic neoplasm. ( 7219469 )
1981
37
Pyonephrosis masquerading as a colonic neoplasm. ( 666971 )
1978
38
A unicryptal colonic adenoma, the smallest colonic neoplasm yet observed in a non-polyposis individual. ( 920664 )
1977
39
Unsuspected perforated adenocarcinoma of the appendix as a second colonic neoplasm: report of a case. ( 849698 )
1977
40
Fecaloma simulating colonic neoplasm. ( 1265606 )
1976
41
Diverticular fecalith in scleroderma simulating colonic neoplasm: report of a case. ( 1149584 )
1975

Variations for Colonic Benign Neoplasm

ClinVar genetic disease variations for Colonic Benign Neoplasm:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 BRAF NM_004333.4(BRAF): c.1799T> A (p.Val600Glu) single nucleotide variant Pathogenic rs113488022 GRCh37 Chromosome 7, 140453136: 140453136
2 BRAF NM_004333.4(BRAF): c.1799T> A (p.Val600Glu) single nucleotide variant Pathogenic rs113488022 GRCh38 Chromosome 7, 140753336: 140753336
3 BRAF NM_004333.4(BRAF): c.1799T> A (p.Val600Glu) single nucleotide variant Pathogenic rs113488022 NCBI36 Chromosome 7, 140099605: 140099605
4 TP53 NM_000546.5(TP53): c.1060C> A (p.Gln354Lys) single nucleotide variant Uncertain significance rs755394212 GRCh37 Chromosome 17, 7573967: 7573967
5 TP53 NM_000546.5(TP53): c.1060C> A (p.Gln354Lys) single nucleotide variant Uncertain significance rs755394212 GRCh38 Chromosome 17, 7670649: 7670649
6 BRAF NM_004333.4(BRAF): c.1799_1800delTGinsAA (p.Val600Glu) indel Likely pathogenic rs121913377 GRCh37 Chromosome 7, 140453135: 140453136
7 BRAF NM_004333.4(BRAF): c.1799_1800delTGinsAA (p.Val600Glu) indel Likely pathogenic rs121913377 GRCh38 Chromosome 7, 140753335: 140753336
8 ERBB3 NM_001982.3(ERBB3): c.850G> A (p.Gly284Arg) single nucleotide variant Likely pathogenic rs1057519803 GRCh37 Chromosome 12, 56481922: 56481922
9 ERBB3 NM_001982.3(ERBB3): c.850G> A (p.Gly284Arg) single nucleotide variant Likely pathogenic rs1057519803 GRCh38 Chromosome 12, 56088138: 56088138

Expression for Colonic Benign Neoplasm

Search GEO for disease gene expression data for Colonic Benign Neoplasm.

Pathways for Colonic Benign Neoplasm

Pathways related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.34 BRAF CTNNB1 KRAS PTGS2
2
Show member pathways
12.04 AREG BRAF CTNNB1 KRAS
3
Show member pathways
11.92 AREG KRAS SMURF1
4 11.82 BRAF CTNNB1 KRAS
5
Show member pathways
11.64 BRAF CTNNB1 KRAS PTGS2
6 11.6 BRAF KRAS PTGS2
7 11.54 BRAF CTNNB1 KRAS
8 11.31 BRAF KRAS SMURF1
9 11.14 BRAF CTNNB1 KRAS PTGS2
10 11 CTNNB1 KRAS
11 10.99 HPGD PTGS2
12 10.91 BRAF KRAS
13 10.79 HPGD PTGS2

GO Terms for Colonic Benign Neoplasm

Biological processes related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 prostaglandin metabolic process GO:0006693 9.46 HPGD PTGS2
2 regulation of cell proliferation GO:0042127 9.46 BRAF CTNNB1 LGR5 PTGS2
3 protein localization to cell surface GO:0034394 9.43 CTNNB1 SMURF1
4 lipoxygenase pathway GO:0019372 9.4 HPGD PTGS2
5 epithelial tube branching involved in lung morphogenesis GO:0060441 9.37 CTNNB1 KRAS
6 ovulation GO:0030728 9.32 HPGD PTGS2
7 ectoderm development GO:0007398 9.26 CTNNB1 SMURF1
8 response to glucocorticoid GO:0051384 9.13 AREG KRAS PTGS2
9 response to estradiol GO:0032355 8.92 AREG CTNNB1 HPGD PTGS2

Molecular functions related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 I-SMAD binding GO:0070411 8.62 CTNNB1 SMURF1

Sources for Colonic Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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