MCID: CLN045
MIFTS: 49

Colonic Benign Neoplasm

Categories: Cancer diseases, Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Colonic Benign Neoplasm

MalaCards integrated aliases for Colonic Benign Neoplasm:

Name: Colonic Benign Neoplasm 12 15
Neoplasm of the Colon 29 6
Neoplasm of Colon 12
Colonic Neoplasms 71
Colon Neoplasm 12
Colonic Tumor 12
Colonic Mass 12

Classifications:



External Ids:

Disease Ontology 12 DOID:235
MeSH 43 D003110
NCIt 49 C2953
UMLS 71 C0009375

Summaries for Colonic Benign Neoplasm

Disease Ontology : 12 An intestinal benign neoplasm that is located in the colon.

MalaCards based summary : Colonic Benign Neoplasm, also known as neoplasm of the colon, is related to colon adenoma and colorectal cancer. An important gene associated with Colonic Benign Neoplasm is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Endometrial cancer. The drugs Acetaminophen and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Colonic Benign Neoplasm

Diseases related to Colonic Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 497)
# Related Disease Score Top Affiliating Genes
1 colon adenoma 32.1 MIR2116 MIR18A MIR15A MIR143 MIR124-1 LGR5
2 colorectal cancer 31.7 TP53 PTGS2 MIR20A MIR18A MIR143 MIR124-1
3 descending colon cancer 31.2 KRAS CDX2
4 adenoma 31.1 TP53 PTGS2 KRAS CTNNB1 CDX2 BRAF
5 appendix cancer 31.0 TP53 KRAS HRAS CDX2
6 familial adenomatous polyposis 1 31.0 CTNNB1 APC
7 in situ carcinoma 30.7 TP53 MIR143 HRAS H2AC18
8 colitis 30.7 PTGS2 CTNNB1 CCR6 BRAF
9 adenocarcinoma 30.7 TP53 PTGS2 KRAS HRAS CTNNB1 CDX2
10 gastritis 30.6 TP53 PTGS2 CDX2 CCR6
11 colon adenocarcinoma 30.5 TP53 PTGS2 KRAS CTNNB1 APC
12 appendix adenocarcinoma 30.4 KRAS HRAS CDX2
13 squamous cell papilloma 30.4 TP53 HRAS
14 hyperplastic polyposis syndrome 30.4 TP53 KRAS BRAF APC
15 lymphoma, hodgkin, classic 30.3 MIR20A MIR18A KDM4C CCR6
16 mucinous adenocarcinoma 30.3 TP53 KRAS CDX2
17 familial adenomatous polyposis 30.3 TP53 PTGS2 KRAS HRAS CTNNB1 APC
18 familial colorectal cancer 30.3 TP53 BRAF APC
19 atrophic gastritis 30.3 TP53 PTGS2 CDX2
20 villous adenoma 30.2 KRAS HRAS CDX2 BRAF APC
21 barrett esophagus 30.2 TP53 PTGS2 CTNNB1 CDX2 APC
22 rectum cancer 30.2 MIR20A MIR143 KRAS HRAS APC
23 ascending colon cancer 30.2 KRAS HRAS CDX2
24 transitional cell carcinoma 30.2 TP53 PTGS2 HRAS BRAF
25 thyroid carcinoma 30.1 TP53 HRAS CTNNB1 BRAF
26 bladder urothelial carcinoma 30.1 TP53 KRAS HRAS CTNNB1 BRAF
27 colorectal adenoma 30.0 TP53 PTGS2 MIR15A KRAS HRAS CTNNB1
28 lymphocytic leukemia 30.0 TP53 MIR15A KRAS CCR6 BRAF
29 bone resorption disease 30.0 H2AC18 CTNNB1 CCR6
30 rectum adenocarcinoma 30.0 TP53 MIR143 KRAS KDM4C HRAS CDX2
31 intrahepatic cholangiocarcinoma 29.9 TP53 KRAS CTNNB1 CDX2 APC
32 large intestine cancer 29.9 MIR532 MIR20A MIR18A MIR15A MIR143 MIR124-1
33 squamous cell carcinoma 29.8 TP53 PTGS2 KDM4C HRAS CTNNB1 BRAF
34 renal cell carcinoma, nonpapillary 29.7 TP53 MIR18A MIR143 MIR10A KDM4C HRAS
35 glioblastoma multiforme 29.7 TP53 PTGS2 KRAS HRAS CTNNB1 BRAF
36 colonic disease 29.7 TP53 MIR20A MIR18A MIR15A MIR143 KRAS
37 melanoma 29.6 TP53 MIR532 MIR15A KRAS HRAS CTNNB1
38 cholangiocarcinoma 29.6 TP53 PTGS2 KRAS CTNNB1 CDX2 BRAF
39 gallbladder cancer 29.6 TP53 PTGS2 MIR143 KRAS CTNNB1 CDX2
40 colorectal adenocarcinoma 29.6 TP53 PTGS2 KRAS HRAS CTNNB1 CDX2
41 gastrointestinal stromal tumor 29.3 TP53 PTGS2 KRAS BRAF
42 esophageal cancer 29.3 TP53 PTGS2 MIR143 MIR124-1 KRAS KDM4C
43 lynch syndrome 29.3 TP53 MIR532 KRAS KDM4C HRAS H2AC18
44 pancreatic cancer 29.1 TP53 PTGS2 MIR20A MIR15A MIR143 MIR10A
45 hepatocellular carcinoma 29.0 TP53 PTGS2 MIR20A MIR18A MIR15A MIR143
46 leukemia, chronic lymphocytic 29.0 TP53 MIR532 MIR20A MIR15A MIR143 KRAS
47 ovarian cancer 28.7 TP53 PTGS2 MIR532 MIR143 KRAS HRAS
48 lung cancer susceptibility 3 28.5 TP53 PTGS2 MIR532 MIR15A MIR143 KRAS
49 lung cancer 28.4 TP53 PTGS2 MIR20A MIR18A MIR15A MIR143
50 intestinal benign neoplasm 28.3 TP53 PTGS2 MIR532 MIR20A MIR18A MIR15A

Graphical network of the top 20 diseases related to Colonic Benign Neoplasm:



Diseases related to Colonic Benign Neoplasm

Symptoms & Phenotypes for Colonic Benign Neoplasm

GenomeRNAi Phenotypes related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

26 (show all 29)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.91 KDM4C
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.91 BRAF
3 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.91 CTNNB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.91 KRAS
5 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.91 APC
6 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.91 KDM4C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.91 BRAF
8 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.91 BRAF
9 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.91 KRAS
10 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.91 APC BRAF CTNNB1 KDM4C KRAS
11 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.91 KDM4C
12 Increased shRNA abundance (Z-score > 2) GR00366-A-191 9.91 CTNNB1 KDM4C
13 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.91 APC
14 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.91 BRAF
15 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.91 KRAS
16 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.91 CTNNB1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.91 APC
18 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.91 KRAS
19 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.91 APC BRAF
20 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.91 BRAF
21 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.91 BRAF
22 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.91 BRAF CTNNB1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.91 APC CTNNB1 KRAS
24 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.91 KRAS
25 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.91 KRAS
26 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.91 CTNNB1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.91 CTNNB1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.91 APC CTNNB1
29 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.91 KRAS

MGI Mouse Phenotypes related to Colonic Benign Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.07 APC BRAF CDX2 CTNNB1 HRAS KDM4C
2 digestive/alimentary MP:0005381 10.06 APC BRAF CDX2 CTNNB1 HRAS KRAS
3 craniofacial MP:0005382 9.98 APC BRAF CTNNB1 HRAS KRAS LGR5
4 integument MP:0010771 9.97 APC BRAF CTNNB1 HRAS KDM4C KRAS
5 neoplasm MP:0002006 9.96 APC BRAF CDX2 CTNNB1 HRAS KDM4C
6 normal MP:0002873 9.81 APC BRAF CCR6 CDX2 CTNNB1 HRAS
7 pigmentation MP:0001186 9.35 APC BRAF CTNNB1 KRAS TP53
8 renal/urinary system MP:0005367 9.23 APC BRAF CTNNB1 HRAS KRAS LGR5

Drugs & Therapeutics for Colonic Benign Neoplasm

Drugs for Colonic Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 422)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
4
Orphenadrine Approved Phase 4 83-98-7 4601
5
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
6
Methadone Approved Phase 4 76-99-3 4095
7
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
8
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
9
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
10
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
11
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
12
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
13
Morphine Approved, Investigational Phase 4 57-27-2 5288826
14
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
15
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
16
Magnesium oxide Approved Phase 4 1309-48-4 14792
17
Glucagon Approved Phase 4 16941-32-5
18 Antipyretics Phase 4
19 Autonomic Agents Phase 4
20 Respiratory System Agents Phase 4
21 Neurotransmitter Agents Phase 4
22 Cholinergic Agents Phase 4
23 Parasympatholytics Phase 4
24 Anti-Arrhythmia Agents Phase 4
25 Sodium Channel Blockers Phase 4
26 Anesthetics, Dissociative Phase 4
27 Diuretics, Potassium Sparing Phase 4
28 Excitatory Amino Acid Antagonists Phase 4
29 Excitatory Amino Acids Phase 4
30 Anticonvulsants Phase 4
31 Cytochrome P-450 Enzyme Inhibitors Phase 4
32 Acetaminophen, hydrocodone drug combination Phase 4
33 Neuromuscular Agents Phase 4
34 Antitussive Agents Phase 4
35 Antiparkinson Agents Phase 4
36 Ketorolac Tromethamine Phase 4
37 Antimanic Agents Phase 4
38 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
39 Muscarinic Antagonists Phase 4
40 Cholinergic Antagonists Phase 4
41 Gastrointestinal Agents Phase 4
42 Narcotics Phase 4
43 Adjuvants, Anesthesia Phase 4
44 Cathartics Phase 4
45 Laxatives Phase 4
46 Polyethylene glycol 3350 Phase 4
47 Incretins Phase 4
48 Glucagon-Like Peptide 1 Phase 4
49 Anti-Anxiety Agents Phase 4
50 Tranquilizing Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 772)
# Name Status NCT ID Phase Drugs
1 Preoperative Assessment of Colon Tumor: A Prospective, Blinded Study. Unknown status NCT00114829 Phase 4
2 A Phase II Study of Tegafur-Uracil as Maintenance Chemotherapy in Patients With Stage II Microsatellite-Stable or Low-Level Microsatellite-Instability Colon Cancer Unknown status NCT02887365 Phase 4 tegafur-uracil
3 Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery as Part of an Enhanced Recovery After Surgery Protocol: A Randomized Prospective Single- Center Trial. Unknown status NCT02958566 Phase 4 Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
4 Multicenter Asia Study in Adjuvant Treatment of Colon Cancer With OxaliplaTin/5FU-LV Completed NCT00263055 Phase 4 oxaliplatin
5 Konzentrationen Von Ertapenem in Kolorektalem Gewebe Completed NCT00535652 Phase 4 Ertapenem
6 Compression Anastomosis: Initial Clinical Experience With the ColonRingTM Completed NCT01056913 Phase 4
7 Effect of Postoperative Laxative on Bowel Function After Colonic Surgery Completed NCT00427492 Phase 4 Magnesia;Placebo
8 Tandem Colonoscopy Study of Narrow Band Imaging Versus White Light Examination to Compare Neoplasia Miss Rates Completed NCT00628147 Phase 4
9 An Open Label Study to Evaluate the Safety of Xeloda as Adjuvant Monotherapy in Patients Who Have Undergone Surgery for Colon Cancer, Dukes Stage C. Completed NCT00502671 Phase 4 capecitabine [Xeloda]
10 Role of Glucagon in Outpatient Colonoscopy? A Prospective Double-Blind Randomized Controlled Trial Completed NCT02078726 Phase 4 Glucagon;Placebo
11 Effect of Intravenous Omega-3 Fatty Acids on the Perioperative Immune Response and Erythrocyte Function in Patients With Colon Cancer Completed NCT02231203 Phase 4 Omegaven;Placebo
12 An Expanded Access Program of AvastinTM (Bevacizumab) in Patients With Metastatic Cancer of the Colon or Rectum Completed NCT02582970 Phase 4 5-Fluorouracil;Bevacizumab;Irinotecan;Oxaliplatin
13 Open-label, Efficacy and Safety Study of Bevacizumab (Avastin®) in Combination With XELOX (Oxaliplatin Plus Xeloda®) for the First-line Treatment of Patients With Metastatic Cancer of the Colon or Rectum - 'OBELIX' Completed NCT00577031 Phase 4 bevacizumab [Avastin];Oxaliplatin;Xeloda
14 Endo-Laparoscopic Approach Versus Conventional Open Surgery in the Management of Obstructing Left-sided Colon Cancer: A Randomized Trial Completed NCT00654212 Phase 4
15 Patient Satisfaction With Propofol for Out Patient Colonoscopy: A Prospective, Randomized, Double-Blind Study Completed NCT02937506 Phase 4 Propofol;Fentanyl Plus Midazolam
16 Effects of Different Types of Perioperative Analgesia on Minimal Residual Disease Development After Colon Cancer Surgery Completed NCT02314871 Phase 4 Piritramide;Morphine
17 A Prospective, Randomized Controlled Trial Comparing the Efficacy and Patient Tolerability of Miralax (PEG 3350) vs. Golytely as Bowel Preparation for Screening Colonoscopy Completed NCT01170754 Phase 4 PEG-3350 and Gatorade;Golytely 4 liters
18 Preoperative Use of the High Protein ONS vs Immunoenhancing ONS in Gastrointestinal Cancer Patients Undergoing Surgery Recruiting NCT03980704 Phase 4 IMPACT;resource protein
19 A Randomized, Open-label Study to Compare Propofol Anesthesia With Sevoflurane Anesthesia in Terms of Overall Survival in Patients With Surgical Intervention for Either Breast-, Colon- or Rectal Cancer Recruiting NCT01975064 Phase 4 Propofol;Sevoflurane
20 Multicenter Randomized Study in Patients With Colorectal Cancer With Unresectable Metastases. Impact of Resection vs no Resection of the Primary Tumour as a Survival Factor Active, not recruiting NCT02015923 Phase 4 Chemotherapy- scheme
21 Italian Multicenter Prospective Randomized Trial to Compare Additive Hemostatic Efficacy of EndoClot System to Prevent Bleeding After Endoscopic Mucosal Resection or Endoscopic Submucosal Dissection of Lesions in the Gastrointestinal Tract Not yet recruiting NCT02688699 Phase 4
22 Phase III Trial of Gemcitabine, Curcumin and Celebrex in Patients With Metastatic Colon Cancer Unknown status NCT00295035 Phase 3 CELECOXIB;CURCUMIN
23 The Effectiveness and Safety of Adjuvant Cytokine-induced Killer Cell Immunotherapy for Stage III Colorectal Cancer Patients After Chemotherapy Unknown status NCT02280278 Phase 3 Adjuvant chemotherapy
24 A Randomized Clinical Trial Comparing Laparoscopic and Open Surgery for Colon Cancer Unknown status NCT00387842 Phase 3
25 A Multicenter Prospective Randomized Clinical Trail on the Efficacy of the Single Port Laparoscopic Surgery Compared With Multiport Laparoscopic Surgery Unknown status NCT01480128 Phase 3
26 Microbiological Spectrum of the Intraperitoneal Surface After Elective Right-sided Colon Cancer: Are There Differences in the Peritoneal Contamination After Performing a Stapled or a Handsewn Anastomosis? Unknown status NCT01458353 Phase 3
27 Immunotherapy of Colon Cancer With Autologous Perchloric Soluble Tumors Extracts Unknown status NCT00002455 Phase 3
28 Phase III Randomized Study of Intensive Adjuvant Chemotherapy for Resected Colon Cancer at High Risk of Recurrence Unknown status NCT00005979 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
29 The Role of Indocyanine Green (ICG) Fluorescence Imaging on Anastomotic Leak and Short-term Outcomes in Robotic Colorectal Surgery: A Prospective Randomized Trial Unknown status NCT02598414 Phase 2, Phase 3
30 5-Fluorouracil-Leucovorin With or Without Carboplatin as Adjuvant Treatment for Primary Dukes B2-C Colon Cancer; Chronomodulated Versus Standard Administration. A Multicenter Randomized Phase III Trial of the GRECCR-Belgium (Study 03). Unknown status NCT00046995 Phase 3 carboplatin;fluorouracil;leucovorin calcium
31 Synergistic Anti-tumor Effect of ChangTai Keli Based on Chemotherapy for Colon Cancer Patients:a Randomized, Parallel-group, Double-blind, Multicenter Clinical Study Unknown status NCT02510118 Phase 2, Phase 3 mFOLFOX6;XELOX;Placebo ChangTai Keli;ChangTai Keli
32 The Influence of Micrometastases on Prognosis and Survival in Stage I-II Colon Cancer Patients: The EnRoute+ Study Unknown status NCT01097265 Phase 2, Phase 3 capecitabine;oxaliplatin
33 Randomized Phase III Intergroup Trial in Resected Stage 2 (Dukes B) Colon Cancer: 6-Month Infusional 5FU-CPT11 (+/- Folinic Acid) Versus Observation - Determination of Biologic Predictive and Response Factors Unknown status NCT00091312 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
34 Pilot / Phase III Randomized Trial Comparing Standard Systemic Therapy to Cytoreduction + Hyperthermic Intraperitoneal Mitomycin C + Standard Systemic Therapy in Patients With Limited Peritoneal Dissemination of Colon Adenocarcinoma Unknown status NCT01167725 Phase 3 FOLFIRI regimen;FOLFOX regimen;capecitabine;fluorouracil;irinotecan hydrochloride;leucovorin calcium;mitomycin C;oxaliplatin
35 A Phase III Randomized Trial Investigating the Duration of Adjuvant Therapy(3 Versus 6 Months) With the Modified FOLFOX 6 or XELOX Regimens for Patients With Stage III Colon Cancer Unknown status NCT00958737 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin;XELOX regimen;Capecitabine
36 A Multicenter Trial Investigating the Duration of Adjuvant Therapy(3 vs. 6 Months) With the FOLFOX 4 or XELOX Regimen for Patients With High Risk Stage II or Stage III Colon Cancer Unknown status NCT01308086 Phase 3 5-Fluorouracil;Leucovorin;Oxaliplatin;Capecitabine;Oxaliplatin;5-Fluorouracil;Leucovorin;Capecitabine;Oxaliplatin;Oxaliplatin
37 Complete Mesocolic Excision (CME) With Central Supplying Vessel Ligation (CVL) Compared With Conventional Surgery for Colon Cancer: a Double-blinded Randomized Study Unknown status NCT02526836 Phase 2, Phase 3
38 Randomized Phase III Study Assessing the Interest of Primary Tumor Resection in Patients With Asymptomatic Colon Cancer and Unresectable Synchronous Liver Metastases. Unknown status NCT02363049 Phase 3 Chemotherapy
39 A Randomized Controlled Trial Comparing the Outcomes of Patients Who Undergo Single Port Laparoscopic Colectomy and Conventional Laparoscopic Colectomy for Colonic Neoplasia Unknown status NCT01101672 Phase 2, Phase 3
40 Multicenter International Study of Oxaliplatin/ 5FU-LV in the Adjuvant Treatment of Colon Cancer Completed NCT00275210 Phase 3 Oxaliplatin (SR96669)
41 A Prospectively Randomized Study on Adjuvant Chemotherapy in Patients With Operated Colon Carcinoma Dukes B (Stage II; T3-4, N0, M0). Completed NCT00309543 Phase 3 Fluorouracil;Leucovorin
42 BLI850 vs an Active Control Bowel Preparation in Adult Subjects Undergoing Colonoscopy Completed NCT00756977 Phase 3 BLI850;polyethylene glycol 3350 based bowel preparation
43 BLI850-302: BLI850 vs an Approved Active Control Bowel Preparation in Adult Subjects Undergoing Colonoscopy Completed NCT00756548 Phase 3 BLI850;polyethylene glycol 3350 based bowel preparation
44 Post-Approved Phase III Study of 1-LV/5FU Therapy Completed NCT00195585 Phase 3 Isovorin;UFT
45 The Effects of Exercise Training on the Health-related Fitness of Colon Cancer Survivors: a Randomized Controlled Trial Completed NCT00813540 Phase 2, Phase 3
46 A Prospectively Randomized Phase III Study on Adjuvant Chemotherapy and Adjuvant Chemo-Immunotherapy in Patients With Operated Colon Carcinoma Dukes C (Stage III; T1-4, N1-30, M0). Completed NCT00309530 Phase 3 5-fluorouracil, levamisol, interferon
47 A Randomized, Double-blind, Placebo-controlled, Phase Lll Study in Patients With Metastatic Adenocarcinoma of the Colon or Rectum Who Are Receiving First-line Chemotherapy With Oxaliplatin/5-fluorouracil/Leucovorin With PTK787/ZK 222584 or Placebo Completed NCT00056459 Phase 3 Vatalanib
48 A Randomized, Double-blind, Placebo-controlled, Phase III Study of Oxaliplatin/5-fluorouracil/Leucovorin With PTK787/ZK 222584 or Placebo in Patients With Previously Treated Metastatic Adenocarcinoma of the Colon or Rectum Completed NCT00056446 Phase 3 Vatalanib
49 Parallel Group Comparison of the New 2 Liter Gut Cleansing Solution NRL 994 Versus Sodium Phosphate Preparation in Routine Colon Cleansing Prior to Colonoscopies for Colon Tumor Screening. Completed NCT00427089 Phase 3 Macrogol 3350 Na sulphate NaCl KCl Ascorbic Acid Na Ascorbate;Sodium Phosphate solution (NaP)
50 Prophylactic Oophorectomy Followed by Chemotherapy Versus Chemotherapy Alone in Colorectal Patients With or Without Ovarian Metastasis Completed NCT01483443 Phase 3

Search NIH Clinical Center for Colonic Benign Neoplasm

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Carmustine
Fluorouracil
irinotecan
Irinotecan hydrochloride
Levamisole
Lomustine

Genetic Tests for Colonic Benign Neoplasm

Genetic tests related to Colonic Benign Neoplasm:

# Genetic test Affiliating Genes
1 Neoplasm of the Colon 29

Anatomical Context for Colonic Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Colonic Benign Neoplasm:

19
Colon

MalaCards organs/tissues related to Colonic Benign Neoplasm:

40
Colon, Liver, Testes, Breast, Lung, Skin, Lymph Node

Publications for Colonic Benign Neoplasm

Articles related to Colonic Benign Neoplasm:

(show all 21)
# Title Authors PMID Year
1
IMFT of the sigmoid colon: a case report. 61
31768246 2019
2
A challenging diagnosis of mesenchymal neoplasm of the colon: colonic dedifferentiated liposarcoma with lymph node metastases-a case report and review of the literature. 61
31501928 2019
3
Gastrointestinal complications and extraintestinal manifestations of inflammatory bowel disease in Taiwan: A population-based study. 61
27838292 2017
4
Impact of procedure on the post-operative infection risk of patients after elective colon surgery. 61
25401415 2014
5
[Turcot syndrome. Rare observation and literature review]. 61
23866578 2013
6
[Adenocarcinoid neoplasm of the colon. Case report]. 61
23234749 2012
7
Incidence of colorectal cancer in Poland in 1999-2008. 61
22291804 2011
8
[Complications of distal intestinal occlusion treatment with endoluminal implants]. 61
21640986 2011
9
Primary sclerosing cholangitis and extraintestinal manifestations in patients with ulcerative colitis and ileal pouch-anal anastomosis. 61
20480253 2010
10
Perivascular epithelioid cell neoplasm of the colon. 61
21160599 2010
11
A palpable, obstructing carcinoma of the colon incarcerated within a large ventral hernia. 61
16843881 2006
12
[Proctological diseases in routine urologic practice]. 61
14579848 2003
13
Patients with multiple myeloma and solid tumors: six case reports. 61
9700587 1998
14
[Laparoscopic-assisted colectomy]. 61
8144081 1994
15
[Colonic tumors: experience at a clinical center in Caracas]. 61
7926615 1994
16
[Neoplasm of the colon and Barrett esophagus]. 61
2813916 1989
17
Psoas abscess demonstrated by CT as the first evidence of carcinoma of the colon. 61
3436132 1987
18
[Carcinoma of the endometrium, neoplasm of the colon and adenocarcinoma of the rectum in the same patient]. 61
3738055 1986
19
[Neoplasm of the colon. Clinical and therapeutic considerations on 80 cases]. 61
6062635 1967
20
[Pseudo-neoplasm of the colon of amebic etiology]. 61
14956115 1952
21
TESTS OF HEPATIC FUNCTION IN CARCINOMA; THEIR VALUE IN CASES OF NEOPLASM OF THE COLON WITH AND WITHOUT METASTASIS TO THE LIVER. 61
17866259 1930

Variations for Colonic Benign Neoplasm

ClinVar genetic disease variations for Colonic Benign Neoplasm:

6 ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 BRAF NM_004333.6(BRAF):c.1799T>A (p.Val600Glu)SNV Pathogenic 13961 rs113488022 7:140453136-140453136 7:140753336-140753336
2 BRAF NM_004333.6(BRAF):c.1799_1800delinsAA (p.Val600Glu)indel Likely pathogenic 376069 rs121913377 7:140453135-140453136 7:140753335-140753336
3 ERBB3 NM_001982.3(ERBB3):c.850G>A (p.Gly284Arg)SNV Likely pathogenic 376167 rs1057519803 12:56481922-56481922 12:56088138-56088138
4 TP53 NM_000546.5(TP53):c.1060C>A (p.Gln354Lys)SNV Uncertain significance 231485 rs755394212 17:7573967-7573967 17:7670649-7670649

Expression for Colonic Benign Neoplasm

Search GEO for disease gene expression data for Colonic Benign Neoplasm.

Pathways for Colonic Benign Neoplasm

Pathways related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 TP53 PTGS2 KRAS HRAS CTNNB1 APC
2
Show member pathways
12.8 TP53 KRAS HRAS CTNNB1 BRAF APC
3 12.75 TP53 PTGS2 KRAS HRAS CTNNB1 BRAF
4
Show member pathways
12.64 TP53 KRAS HRAS CTNNB1 CDX2 BRAF
5
Show member pathways
12.54 TP53 PTGS2 KRAS HRAS CTNNB1 BRAF
6
Show member pathways
12.42 TP53 KRAS HRAS CTNNB1 BRAF
7
Show member pathways
12.4 TP53 LGR5 KRAS HRAS BRAF APC
8
Show member pathways
12.39 TP53 KRAS HRAS CTNNB1
9
Show member pathways
12.35 KRAS HRAS CTNNB1 BRAF APC
10
Show member pathways
12.3 PTGS2 KRAS HRAS CTNNB1 BRAF
11
Show member pathways
12.15 TP53 KRAS HRAS BRAF
12
Show member pathways
12.13 TP53 KRAS HRAS BRAF
13 12.11 TP53 KRAS CTNNB1 BRAF
14
Show member pathways
12.09 TP53 KRAS HRAS BRAF
15 12.04 KRAS HRAS CTNNB1 APC
16 12.04 TP53 MIR10A KRAS HRAS CTNNB1 BRAF
17 11.96 KRAS HRAS CTNNB1 APC
18 11.92 TP53 KRAS HRAS CTNNB1
19 11.9 PTGS2 KRAS HRAS BRAF
20 11.86 TP53 KRAS HRAS CTNNB1 APC
21 11.85 TP53 PTGS2 KRAS CTNNB1 BRAF APC
22 11.85 TP53 PTGS2 MIR20A MIR18A MIR15A MIR143
23 11.76 MIR20A MIR18A MIR10A
24
Show member pathways
11.75 KRAS HRAS BRAF
25 11.67 TP53 KRAS HRAS
26 11.66 TP53 KRAS HRAS BRAF
27
Show member pathways
11.64 KRAS HRAS BRAF
28 11.63 TP53 KRAS HRAS
29 11.59 KRAS HRAS BRAF
30 11.49 PTGS2 KRAS HRAS
31 11.48 TP53 KRAS HRAS CTNNB1 BRAF APC
32 11.41 KRAS HRAS BRAF
33 11.34 KRAS HRAS BRAF
34 11.25 KRAS HRAS BRAF
35 11.1 KRAS HRAS CTNNB1 APC

GO Terms for Colonic Benign Neoplasm

Cellular components related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Wnt signalosome GO:1990909 8.62 CTNNB1 APC

Biological processes related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.91 PTGS2 KRAS KDM4C HRAS CTNNB1 CDX2
2 positive regulation of apoptotic process GO:0043065 9.88 TP53 PTGS2 MIR15A CTNNB1 APC
3 negative regulation of neuron apoptotic process GO:0043524 9.76 MIR124-1 KRAS HRAS BRAF
4 positive regulation of gene expression GO:0010628 9.73 TP53 KRAS KDM4C HRAS CTNNB1 BRAF
5 negative regulation of gene expression GO:0010629 9.72 TP53 MIR20A MIR124-1 HRAS CTNNB1
6 Ras protein signal transduction GO:0007265 9.69 TP53 KRAS HRAS
7 negative regulation of angiogenesis GO:0016525 9.67 MIR15A MIR143 MIR10A CTNNB1
8 negative regulation of cell proliferation GO:0008285 9.63 TP53 PTGS2 MIR15A HRAS CTNNB1 APC
9 negative regulation of fibroblast migration GO:0010764 9.52 MIR124-1 BRAF
10 response to isolation stress GO:0035900 9.49 KRAS HRAS
11 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.4 MIR20A MIR143
12 regulation of cell proliferation GO:0042127 9.35 TP53 PTGS2 LGR5 CTNNB1 BRAF
13 gene silencing by miRNA GO:0035195 9.1 MIR20A MIR18A MIR15A MIR143 MIR124-1 MIR10A

Molecular functions related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.1 MIR20A MIR18A MIR15A MIR143 MIR124-1 MIR10A

Sources for Colonic Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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