MCID: CLN045
MIFTS: 48

Colonic Benign Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Colonic Benign Neoplasm

MalaCards integrated aliases for Colonic Benign Neoplasm:

Name: Colonic Benign Neoplasm 12 15
Neoplasm of the Colon 30 6
Neoplasm of Colon 12
Colonic Neoplasms 74
Colon Neoplasm 12
Colonic Tumor 12
Colonic Mass 12

Classifications:



External Ids:

Disease Ontology 12 DOID:235
MeSH 45 D003110
NCIt 51 C2953
UMLS 74 C0009375

Summaries for Colonic Benign Neoplasm

Disease Ontology : 12 An intestinal benign neoplasm that is located in the colon.

MalaCards based summary : Colonic Benign Neoplasm, also known as neoplasm of the colon, is related to colon adenoma and sigmoid neoplasm. An important gene associated with Colonic Benign Neoplasm is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are Gastric cancer and Pathways in cancer. The drugs Tegafur and Gabapentin have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and testes, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Colonic Benign Neoplasm

Diseases related to Colonic Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 colon adenoma 31.8 APC KRAS LGR5
2 sigmoid neoplasm 31.8 CEACAM5 KRAS
3 familial adenomatous polyposis 1 30.6 APC CTNNB1
4 hyperplastic polyposis syndrome 29.7 APC BRAF KRAS
5 familial adenomatous polyposis 29.7 APC CTNNB1 KRAS PTGS2
6 adenocarcinoma 29.5 APC BRAF CTNNB1 KRAS PTGS2
7 adenoma 29.3 APC BRAF CTNNB1 KRAS PTGS2
8 large intestine cancer 29.2 APC BRAF CEACAM5 CTNNB1 KRAS LGR5
9 colorectal adenocarcinoma 29.0 BRAF CEACAM5 CTNNB1 KRAS PTGS2
10 cholangiocarcinoma 29.0 BRAF CEACAM5 CTNNB1 KRAS PTGS2
11 lung cancer susceptibility 3 28.7 APC BRAF CEACAM5 CTNNB1 KRAS PTGS2
12 colorectal cancer 11.8
13 neuroendocrine tumor of the colon 11.2
14 lynch syndrome i 11.0
15 colorectal cancer, hereditary nonpolyposis, type 2 11.0
16 colorectal cancer, hereditary nonpolyposis, type 8 11.0
17 colorectal cancer, hereditary nonpolyposis, type 6 11.0
18 colorectal cancer, hereditary nonpolyposis, type 4 11.0
19 colorectal cancer, hereditary nonpolyposis, type 5 11.0
20 colorectal cancer, hereditary nonpolyposis, type 7 11.0
21 colon squamous cell carcinoma 10.4
22 familial colorectal cancer type x 10.3
23 papillary craniopharyngioma 10.3 BRAF CTNNB1
24 desmoid disease, hereditary 10.3 APC CTNNB1
25 polyposis syndrome, hereditary mixed, 1 10.3 APC PTGS2
26 erdheim-chester disease 10.3 BRAF SERPINA3
27 desmoid tumor 10.3 APC CTNNB1
28 adenosquamous gallbladder carcinoma 10.2 CEACAM5 SERPINA3
29 familial adenomatous polyposis 2 10.2
30 hepatic adenomas, familial 10.2 APC CTNNB1
31 periampullary adenoma 10.2 APC KRAS
32 mutyh-associated polyposis 10.2 APC KRAS
33 clear cell adenoma 10.2 CEACAM5 CTNNB1
34 mature teratoma 10.2 BRAF KRAS
35 apocrine adenoma 10.1 CEACAM5 KRAS
36 pilocytic astrocytoma 10.1 BRAF KRAS
37 pancreatic cystadenocarcinoma 10.1 CEACAM5 KRAS
38 aggressive digital papillary adenocarcinoma 10.1 CEACAM5 KRAS
39 juvenile polyposis syndrome 10.1
40 polyposis, skin pigmentation, alopecia, and fingernail changes 10.1
41 familial adenomatous polyposis 3 10.1
42 appendix cancer 10.1
43 descending colon cancer 10.1
44 splenic flexure cancer 10.1
45 cecal benign neoplasm 10.1
46 cecum carcinoma 10.1
47 ascending colon cancer 10.1
48 hepatic flexure cancer 10.1
49 transverse colon cancer 10.1
50 attenuated familial adenomatous polyposis 10.1

Graphical network of the top 20 diseases related to Colonic Benign Neoplasm:



Diseases related to Colonic Benign Neoplasm

Symptoms & Phenotypes for Colonic Benign Neoplasm

MGI Mouse Phenotypes related to Colonic Benign Neoplasm:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.15 APC BRAF CCDC80 CTNNB1 KRAS LGR5
2 growth/size/body region MP:0005378 10.09 APC BRAF CCDC80 CTNNB1 KRAS LGR5
3 endocrine/exocrine gland MP:0005379 10.06 APC BRAF CCDC80 CTNNB1 KRAS LGR5
4 digestive/alimentary MP:0005381 10.02 APC BRAF CCDC80 CTNNB1 KRAS LGR5
5 neoplasm MP:0002006 9.87 APC BRAF CCDC80 CTNNB1 KRAS LGR5
6 liver/biliary system MP:0005370 9.85 APC BRAF CCDC80 CTNNB1 KRAS PTGS2
7 hearing/vestibular/ear MP:0005377 9.8 APC BRAF CTNNB1 KRAS SMURF1
8 normal MP:0002873 9.8 APC BRAF CCDC80 CTNNB1 KRAS PTGS2
9 pigmentation MP:0001186 9.46 APC BRAF CTNNB1 KRAS
10 renal/urinary system MP:0005367 9.43 APC BRAF CTNNB1 KRAS LGR5 PTGS2
11 skeleton MP:0005390 9.17 APC BRAF CTNNB1 KRAS PLEKHO1 PTGS2

Drugs & Therapeutics for Colonic Benign Neoplasm

Drugs for Colonic Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 428)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tegafur Approved, Investigational Phase 4,Phase 3,Not Applicable 17902-23-7 5386
2
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
3
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
4
Morphine Approved, Investigational Phase 4,Not Applicable 57-27-2 5288826
5
Orphenadrine Approved Phase 4 83-98-7 4601
6
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
7
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
8
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
9
Methadone Approved Phase 4 76-99-3 4095
10
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
11
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
12
Acetaminophen Approved Phase 4,Not Applicable 103-90-2 1983
13
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
14
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
15
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
16
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
17
Oxaliplatin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 61825-94-3 6857599 5310940 9887054 43805
18
Fluorouracil Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 51-21-8 3385
19
Capecitabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 154361-50-9 60953
20
leucovorin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 58-05-9 6006 143
21
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 100286-90-6, 97682-44-5 60838
22
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
23
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
24
Tocopherol Approved, Investigational Phase 4,Not Applicable 1406-66-2 14986
25
Magnesium oxide Approved Phase 4 1309-48-4 14792
26
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
27
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 216974-75-3
28
Panitumumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 339177-26-3 50070211
29
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
30
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037
31
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 59-02-9 14985
32 Tocotrienol Investigational Phase 4,Not Applicable 6829-55-6
33 Cola Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
34 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
35 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
36 Anti-Anxiety Agents Phase 4
37 Adjuvants, Anesthesia Phase 4,Not Applicable
38 Antitussive Agents Phase 4
39 Acetaminophen, hydrocodone drug combination Phase 4
40 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
41 Muscarinic Antagonists Phase 4
42 Respiratory System Agents Phase 4
43 Anesthetics, General Phase 4,Not Applicable
44 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
45 Diuretics, Potassium Sparing Phase 4
46 Anticonvulsants Phase 4,Phase 1,Phase 2
47 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
48 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
49 Excitatory Amino Acids Phase 4
50 Tranquilizing Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 753)
# Name Status NCT ID Phase Drugs
1 Preoperative Assessment of Colon Tumor Unknown status NCT00114829 Phase 4
2 A Phase II Study of Tegafur-Uracil as Maintenance Chemotherapy in Patients With Stage II of Colon Cancer Unknown status NCT02887365 Phase 4 tegafur-uracil
3 Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery Unknown status NCT02958566 Phase 4 Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
4 Clinical Evaluation of Narrow Band Imaging Colonoscope Completed NCT00628147 Phase 4
5 Endo-Laparoscopic Approach Versus Conventional Open Surgery in Obstructing Left-sided Colon Cancer: RCT Completed NCT00654212 Phase 4
6 MASCOT : Multicenter Asia Study in Adjuvant Treatment of Colon Cancer With OxaliplaTin/5FU-LV Completed NCT00263055 Phase 4 oxaliplatin
7 Concentration of Ertapenem in Colorectal Tissue Completed NCT00535652 Phase 4 Ertapenem
8 NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery Completed NCT01056913 Phase 4
9 Effect of Omega-3 Fatty Acids on the Perioperative Immune Response and Erythrocyte Function Completed NCT02231203 Phase 4 Omegaven;Placebo
10 Effect of Postoperative Laxative on Bowel Function After Colonic Surgery Completed NCT00427492 Phase 4 Magnesia;Placebo
11 Effects of Different Types of Perioperative Analgesia on Minimal Residual Disease Development After Colon Cancer Surgery Completed NCT02314871 Phase 4 Piritramide;Morphine
12 A Study of Xeloda (Capecitabine) as Adjuvant Monotherapy in Patients With Colon Cancer. Completed NCT00502671 Phase 4 capecitabine [Xeloda]
13 Chemotherapy Combined With CIK Treating Colon Cancer Completed NCT03084809 Phase 4 Cytokine-induced killer cells+ FOLFOX4;FOLFOX4
14 A Study of Bevacizumab (Avastin) in Combination With Chemotherapy in Participants With Metastatic Cancer of the Colon or Rectum Completed NCT02582970 Phase 4 5-Fluorouracil;Bevacizumab;Irinotecan;Oxaliplatin
15 OBELIX Study: A Study of Avastin (Bevacizumab) in Combination With XELOX in Patients With Metastatic Cancer of the Colon or Rectum. Completed NCT00577031 Phase 4 bevacizumab [Avastin];Oxaliplatin;Xeloda
16 Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia Recruiting NCT01975064 Phase 4 Propofol;Sevoflurane
17 Resection vs no Resection of the Primary in Colorectal Cancer With Unresectable Metastases Active, not recruiting NCT02015923 Phase 4 Chemotherapy- scheme
18 Additive Hemostatic Efficacy of EndoClot After EMR or ESD in the Gastrointestinal Tract Not yet recruiting NCT02688699 Phase 4
19 Complete Mesocolon Excision vs Locoregional Lymphadenectomy in Sigmoid Colon Cancer (CMELL) Not yet recruiting NCT03083951 Phase 4
20 Multicenter Single-port Colectomy RCT Unknown status NCT01480128 Phase 3
21 Phase III Trial of Gemcitabine, Curcumin and Celebrex in Patients With Metastatic Colon Cancer Unknown status NCT00295035 Phase 3 CELECOXIB;CURCUMIN
22 COlon Cancer Laparoscopic or Open Resection Unknown status NCT00387842 Phase 3
23 The Role of Indocyanine Green (ICG) Fluorescence Imaging on Anastomotic Leak in Robotic Colorectal Surgery Unknown status NCT02598414 Phase 2, Phase 3
24 Synergistic Anti-tumor Effect of ChangTai Keli for Colon Cancer Patients Unknown status NCT02510118 Phase 2, Phase 3 mFOLFOX6;XELOX;Placebo ChangTai Keli;ChangTai Keli
25 Trial for Single Port Versus Conventional Laparoscopic Colectomy Unknown status NCT01101672 Phase 2, Phase 3
26 Combination Chemotherapy for 3 Months or 6 Months in Treating Patients With Stage III Colon Cancer Unknown status NCT00958737 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin;XELOX regimen;Capecitabine
27 Fluorouracil and Irinotecan With or Without Leucovorin Compared With Observation in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer Unknown status NCT00091312 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
28 Combination Chemotherapy in Treating Patients With Colon Cancer Unknown status NCT00046995 Phase 3 carboplatin;fluorouracil;leucovorin calcium
29 Combination Chemotherapy With or Without Irinotecan in Treating Patients With Stage III Colon Cancer Unknown status NCT00005979 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
30 Microbiological Spectrum of the Intraperitoneal Surface After Elective Right-sided Colon Cancer Unknown status NCT01458353 Phase 3
31 Study of Micrometastases in Patients With Stage I or Stage II Localized Colon Cancer That Can Be Removed by Surgery Unknown status NCT01097265 Phase 2, Phase 3 capecitabine;oxaliplatin
32 Immunotherapy After Surgery in Treating Patients With Breast Cancer, Colon Cancer, or Melanoma Unknown status NCT00002455 Phase 3
33 Colectomy in Patients With Asymptomatic and Unresectable Stage IV Colon Cancer Unknown status NCT02363049 Phase 3 Chemotherapy
34 Comparison of 2L NRL994 With NaP Preparation in Colon Cleansing Prior to Colonoscopies for Colon Tumor Screening Completed NCT00427089 Phase 3 Macrogol 3350 Na sulphate NaCl KCl Ascorbic Acid Na Ascorbate;Sodium Phosphate solution (NaP)
35 MOSAIC - Multicenter International Study of Oxaliplatin/ 5FU-LV in the Adjuvant Treatment of Colon Cancer Completed NCT00275210 Phase 3 Oxaliplatin (SR96669)
36 The Effects of Exercise Training on the Health-related Fitness of Colon Cancer Survivors Completed NCT00813540 Phase 2, Phase 3
37 A Randomized Trial of Cancer Risk and Health Education in Relatives of Colorectal Cancer Patients Completed NCT00188305 Phase 3
38 Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Metastatic Colorectal Cancer. Completed NCT00056459 Phase 3 Vatalanib
39 Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Previously Treated Metastatic Colorectal Cancer Completed NCT00056446 Phase 3 Vatalanib
40 SLN in Colon Cancer Using a Multimodal Tracer Completed NCT02850783 Phase 2, Phase 3
41 "Ultra" Enhanced Recovery After Surgery (E.R.A.S.) in Laparoscopic Colectomy for Cancer Completed NCT02727153 Phase 3
42 Laparoscopic Versus Open Left Colonic Resection Completed NCT00894725 Phase 3
43 Effect of Exercise on Biomarkers of Colon Cancer Risk Completed NCT00668161 Phase 2, Phase 3
44 FOLFOX-4 3months Versus 6 Months and Bevacizumab as Adjuvant Therapy for Patients With Stage II/III Colon Cancer Completed NCT00646607 Phase 3 FOLFOX (Oxaliplatin, 5Fluorouracil, Lederfolin);FOLFOX (Oxaliplatin, 5Fluorouracil, Lederfolin)
45 Randomized Trial on Adjuvant Chemotherapy in Colon Carcinoma Dukes B Completed NCT00309543 Phase 3 Fluorouracil;Leucovorin
46 Randomized Study on Adjuvant Chemotherapy and Adjuvant Chemo-Immunotherapy in Colon Carcinoma Dukes C Completed NCT00309530 Phase 3 5-fluorouracil, levamisol, interferon
47 Study Evaluating Isovorin in Colon Cancer Completed NCT00195585 Phase 3 Isovorin;UFT
48 Fluorouracil Plus Leucovorin With or Without Oxaliplatin in Treating Patients With Stage II or Stage III Colon Cancer Completed NCT00004931 Phase 3 leucovorin calcium;fluorouracil;oxaliplatin
49 Tegafur-Uracil and Leucovorin or S-1 in Treating Patients With Stage III Colon Cancer That Has Been Completely Removed by Surgery Completed NCT00660894 Phase 3 folinate calcium;tegafur-uracil;tegafur-gimeracil-oteracil potassium
50 Fluorouracil, Semustine, and Vincristine Compared With BCG in Treating Patients With Dukes' B or Dukes' C Colon Cancer That Has Been Removed By Surgery Completed NCT00427570 Phase 3 fluorouracil;semustine;vincristine sulfate

Search NIH Clinical Center for Colonic Benign Neoplasm

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Colonic Benign Neoplasm

Genetic tests related to Colonic Benign Neoplasm:

# Genetic test Affiliating Genes
1 Neoplasm of the Colon 30

Anatomical Context for Colonic Benign Neoplasm

MalaCards organs/tissues related to Colonic Benign Neoplasm:

42
Colon, Liver, Testes, Lung, Breast, Lymph Node, Kidney

The Foundational Model of Anatomy Ontology organs/tissues related to Colonic Benign Neoplasm:

20
The Colon

Publications for Colonic Benign Neoplasm

Articles related to Colonic Benign Neoplasm:

# Title Authors Year
1
Perivascular epithelioid cell neoplasm of the colon. ( 21160599 )
2010
2
TESTS OF HEPATIC FUNCTION IN CARCINOMA; THEIR VALUE IN CASES OF NEOPLASM OF THE COLON WITH AND WITHOUT METASTASIS TO THE LIVER. ( 17866259 )
1930

Variations for Colonic Benign Neoplasm

ClinVar genetic disease variations for Colonic Benign Neoplasm:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 BRAF NM_004333.5(BRAF): c.1799T> A (p.Val600Glu) single nucleotide variant Pathogenic rs113488022 GRCh37 Chromosome 7, 140453136: 140453136
2 BRAF NM_004333.5(BRAF): c.1799T> A (p.Val600Glu) single nucleotide variant Pathogenic rs113488022 GRCh38 Chromosome 7, 140753336: 140753336
3 BRAF NM_004333.5(BRAF): c.1799T> A (p.Val600Glu) single nucleotide variant Pathogenic rs113488022 NCBI36 Chromosome 7, 140099605: 140099605
4 TP53 NM_000546.5(TP53): c.1060C> A (p.Gln354Lys) single nucleotide variant Uncertain significance rs755394212 GRCh37 Chromosome 17, 7573967: 7573967
5 TP53 NM_000546.5(TP53): c.1060C> A (p.Gln354Lys) single nucleotide variant Uncertain significance rs755394212 GRCh38 Chromosome 17, 7670649: 7670649
6 BRAF NM_004333.4(BRAF): c.1799_1800delTGinsAA (p.Val600Glu) indel Likely pathogenic rs121913377 GRCh37 Chromosome 7, 140453135: 140453136
7 BRAF NM_004333.4(BRAF): c.1799_1800delTGinsAA (p.Val600Glu) indel Likely pathogenic rs121913377 GRCh38 Chromosome 7, 140753335: 140753336
8 ERBB3 NM_001982.3(ERBB3): c.850G> A (p.Gly284Arg) single nucleotide variant Likely pathogenic rs1057519803 GRCh37 Chromosome 12, 56481922: 56481922
9 ERBB3 NM_001982.3(ERBB3): c.850G> A (p.Gly284Arg) single nucleotide variant Likely pathogenic rs1057519803 GRCh38 Chromosome 12, 56088138: 56088138

Expression for Colonic Benign Neoplasm

Search GEO for disease gene expression data for Colonic Benign Neoplasm.

Pathways for Colonic Benign Neoplasm

Pathways related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.53 APC BRAF CTNNB1 KRAS
2 12.44 APC BRAF CTNNB1 KRAS PTGS2
3
Show member pathways
12.29 APC BRAF CTNNB1 KRAS PTGS2
4
Show member pathways
12.2 APC CTNNB1 LGR5
5
Show member pathways
12.17 APC BRAF CTNNB1 KRAS
6
Show member pathways
12.17 APC BRAF KRAS LGR5
7
Show member pathways
12.06 BRAF CTNNB1 KRAS PTGS2
8 12.03 APC CTNNB1 SMURF1
9 11.91 BRAF CTNNB1 KRAS
10 11.84 APC CTNNB1 KRAS
11 11.76 APC CTNNB1 KRAS
12 11.71 APC CTNNB1 KRAS
13 11.69 BRAF KRAS PTGS2
14 11.59 BRAF KRAS SMURF1
15 11.3 APC BRAF CTNNB1 KRAS
16 11.24 APC BRAF CTNNB1 KRAS PTGS2
17 11.02 BRAF KRAS
18 10.94 APC CTNNB1
19 10.81 APC CTNNB1 KRAS
20 10.77 APC CTNNB1

GO Terms for Colonic Benign Neoplasm

Cellular components related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 catenin complex GO:0016342 9.16 APC CTNNB1
2 beta-catenin destruction complex GO:0030877 8.96 APC CTNNB1
3 Wnt signalosome GO:1990909 8.62 APC CTNNB1

Biological processes related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 beta-catenin destruction complex disassembly GO:1904886 9.37 APC CTNNB1
2 protein localization to cell surface GO:0034394 9.32 CTNNB1 SMURF1
3 cell fate specification GO:0001708 9.26 APC CTNNB1
4 epithelial tube branching involved in lung morphogenesis GO:0060441 9.16 CTNNB1 KRAS
5 ectoderm development GO:0007398 8.96 CTNNB1 SMURF1
6 regulation of cell proliferation GO:0042127 8.92 BRAF CTNNB1 LGR5 PTGS2

Molecular functions related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 I-SMAD binding GO:0070411 8.62 CTNNB1 SMURF1

Sources for Colonic Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....