MCID: CLN045
MIFTS: 52

Colonic Benign Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Colonic Benign Neoplasm

MalaCards integrated aliases for Colonic Benign Neoplasm:

Name: Colonic Benign Neoplasm 12 15
Neoplasm of the Colon 29 6
Neoplasm of Colon 12
Colonic Neoplasms 72
Colon Neoplasm 12
Colonic Tumor 12
Colonic Mass 12

Classifications:



External Ids:

Disease Ontology 12 DOID:235
MeSH 44 D003110
NCIt 50 C2953
UMLS 72 C0009375

Summaries for Colonic Benign Neoplasm

Disease Ontology : 12 An intestinal benign neoplasm that is located in the colon.

MalaCards based summary : Colonic Benign Neoplasm, also known as neoplasm of the colon, is related to colon adenoma and colorectal cancer, hereditary nonpolyposis, type 7. An important gene associated with Colonic Benign Neoplasm is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are fMLP Pathway and Human cytomegalovirus infection. The drugs Acetaminophen and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include colon, colon and liver, and related phenotypes are Decreased viability in esophageal squamous lineage and Increased cell migration

Related Diseases for Colonic Benign Neoplasm

Diseases related to Colonic Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 385)
# Related Disease Score Top Affiliating Genes
1 colon adenoma 32.5 LGR5 KRAS APC
2 colorectal cancer, hereditary nonpolyposis, type 7 32.3 MSH2 MLH1
3 sigmoid neoplasm 31.7 KRAS HRAS CEACAM5
4 familial adenomatous polyposis 1 31.3 CTNNB1 APC
5 attenuated familial adenomatous polyposis 31.0 MSH2 APC
6 papilloma 30.1 TP53 ODC1 CCND1
7 villous adenoma 30.0 KRAS CDX2 BRAF
8 hyperplastic polyposis syndrome 29.9 TP53 KRAS BRAF APC
9 liver angiosarcoma 29.9 TP53 KRAS HRAS
10 atrophic gastritis 29.9 TP53 ODC1 CDX2
11 mucinous adenocarcinoma 29.9 MLH1 KRAS CDX2
12 mismatch repair cancer syndrome 29.7 MSH2 MLH1 CTNNB1 APC
13 leukemia, chronic lymphocytic 2 29.7 TP53 KRAS HRAS BRAF
14 familial colorectal cancer 29.4 TP53 MSH2 MLH1 APC
15 intrahepatic cholangiocarcinoma 29.3 TP53 KRAS CTNNB1 CDX2
16 transitional cell carcinoma 29.3 TP53 PTGS2 MSH2 HRAS BRAF
17 leukemia, chronic lymphocytic 29.0 TP53 KRAS HRAS CCND1 BRAF
18 adenocarcinoma 28.8 TP53 PTGS2 MLH1 KRAS HRAS CTNNB1
19 cecum adenocarcinoma 28.7 MSH2 MLH1 KRAS HRAS CDX2
20 barrett esophagus 28.7 TP53 PTGS2 ODC1 CDX2 CCND1 APC
21 colon adenocarcinoma 28.5 PTGS2 ODC1 MLH1 KRAS CTNNB1 CEACAM5
22 adenoma 28.5 TP53 PTGS2 ODC1 MSH2 MLH1 KRAS
23 bladder urothelial carcinoma 28.4 TP53 MLH1 KRAS HRAS CTNNB1 CCND1
24 gallbladder cancer 28.4 TP53 PTGS2 MLH1 KRAS CEACAM5
25 squamous cell carcinoma 28.4 TP53 PTGS2 KDM4C HRAS CTNNB1 CCND1
26 ovarian cancer 28.1 TP53 MSH2 MLH1 KRAS CTNNB1 CCND1
27 colorectal adenoma 27.9 TP53 PTGS2 ODC1 MSH2 MLH1 KRAS
28 familial adenomatous polyposis 27.8 TP53 PTGS2 ODC1 MSH2 MLH1 KRAS
29 lynch syndrome 27.8 TP53 MSH2 MLH1 KRAS CTNNB1 CCND1
30 endometrial cancer 27.7 TP53 MSH2 MLH1 KRAS HRAS CTNNB1
31 hepatocellular carcinoma 27.5 TP53 PTGS2 KRAS HRAS CTNNB1 CEACAM5
32 colorectal cancer 27.4 TP53 PTGS2 ODC1 MSH2 MLH1 KRAS
33 pancreatic cancer 27.3 TP53 KRAS HRAS CTNNB1 CEACAM5 CDX2
34 lung cancer 27.1 TP53 PTGS2 MLH1 KRAS HRAS CEACAM5
35 cholangiocarcinoma 26.9 TP53 PTGS2 KRAS CTNNB1 CEACAM5 CDX2
36 esophageal cancer 26.6 TP53 PTGS2 ODC1 KRAS HRAS CTNNB1
37 colorectal adenocarcinoma 26.3 TP53 PTGS2 MSH2 MLH1 KRAS HRAS
38 lung cancer susceptibility 3 26.2 TP53 PTGS2 KRAS HRAS CTNNB1 CEACAM5
39 colonic disease 25.7 TP53 PTGS2 MSH2 MLH1 LGR5 KRAS
40 breast cancer 25.6 TP53 PTGS2 ODC1 MSH2 MLH1 KRAS
41 large intestine cancer 24.2 TP53 PTGS2 ODC1 MSH2 MLH1 LGR5
42 intestinal benign neoplasm 24.1 TP53 PTGS2 ODC1 MSH2 MLH1 LGR5
43 neuroendocrine tumor of the colon 11.3
44 lynch syndrome i 11.1
45 colorectal cancer, hereditary nonpolyposis, type 2 11.1
46 colorectal cancer, hereditary nonpolyposis, type 8 11.1
47 colorectal cancer, hereditary nonpolyposis, type 6 11.1
48 colorectal cancer, hereditary nonpolyposis, type 4 11.1
49 colorectal cancer, hereditary nonpolyposis, type 5 11.1
50 desmoid disease, hereditary 10.7 CTNNB1 APC

Graphical network of the top 20 diseases related to Colonic Benign Neoplasm:



Diseases related to Colonic Benign Neoplasm

Symptoms & Phenotypes for Colonic Benign Neoplasm

GenomeRNAi Phenotypes related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.61 APC BRAF CCND1 CTNNB1 HRAS KDM4C
2 Increased cell migration GR00055-A-3 8.92 BRAF CTNNB1 HRAS KRAS

MGI Mouse Phenotypes related to Colonic Benign Neoplasm:

46 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.44 APC BRAF CCND1 CDX2 CTNNB1 HPGD
2 homeostasis/metabolism MP:0005376 10.38 APC BRAF CCND1 CDX2 CTNNB1 HPGD
3 digestive/alimentary MP:0005381 10.36 APC BRAF CCND1 CDX2 CTNNB1 HRAS
4 endocrine/exocrine gland MP:0005379 10.35 APC BRAF CCND1 CDX2 CTNNB1 HPGD
5 mortality/aging MP:0010768 10.35 APC BRAF CCND1 CDX2 CTNNB1 HPGD
6 growth/size/body region MP:0005378 10.34 APC BRAF CCND1 CDX2 CTNNB1 HRAS
7 cardiovascular system MP:0005385 10.3 APC BRAF CCND1 CDX2 CTNNB1 HPGD
8 neoplasm MP:0002006 10.27 APC BRAF CCND1 CDX2 CTNNB1 HRAS
9 hematopoietic system MP:0005397 10.25 APC BRAF CCND1 CTNNB1 KDM4C KRAS
10 integument MP:0010771 10.25 APC BRAF CCND1 CTNNB1 HRAS KRAS
11 immune system MP:0005387 10.22 APC BRAF CCND1 CTNNB1 KDM4C KRAS
12 craniofacial MP:0005382 10.19 APC BRAF CCND1 CTNNB1 HRAS KRAS
13 embryo MP:0005380 10.18 APC BRAF CDX2 CTNNB1 KRAS ODC1
14 normal MP:0002873 10.1 APC BRAF CCND1 CDX2 CTNNB1 HRAS
15 limbs/digits/tail MP:0005371 9.97 APC BRAF CDX2 CTNNB1 KRAS TP53
16 reproductive system MP:0005389 9.96 APC BRAF CCND1 CDX2 CTNNB1 HPGD
17 renal/urinary system MP:0005367 9.92 APC BRAF CTNNB1 HRAS KRAS LGR5
18 no phenotypic analysis MP:0003012 9.91 CTNNB1 HRAS KDM4C KRAS PTGS2 TP53
19 respiratory system MP:0005388 9.81 BRAF CCND1 CTNNB1 HRAS KRAS LGR5
20 pigmentation MP:0001186 9.77 APC BRAF CTNNB1 KRAS TP53
21 skeleton MP:0005390 9.61 APC BRAF CCND1 CDX2 CTNNB1 HRAS
22 vision/eye MP:0005391 9.23 APC BRAF CCND1 CTNNB1 KRAS MLH1

Drugs & Therapeutics for Colonic Benign Neoplasm

Drugs for Colonic Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 439)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
4
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
5
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
6
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
7
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
8
Orphenadrine Approved Phase 4 83-98-7 4601
9
Methadone Approved, Illicit Phase 4 76-99-3 4095
10
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
11
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
12
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
13
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
14
Morphine Approved, Investigational Phase 4 57-27-2 5288826
15
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
16
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
17
Magnesium oxide Approved Phase 4 1309-48-4 14792
18
Glucagon Approved Phase 4 16941-32-5
19 Autonomic Agents Phase 4
20 Neurotransmitter Agents Phase 4
21 Cholinergic Agents Phase 4
22 Parasympatholytics Phase 4
23 Anticonvulsants Phase 4
24 Sodium Channel Blockers Phase 4
25 Diuretics, Potassium Sparing Phase 4
26 Excitatory Amino Acid Antagonists Phase 4
27 Anti-Arrhythmia Agents Phase 4
28 Anesthetics, Dissociative Phase 4
29 Excitatory Amino Acids Phase 4
30 Neuromuscular Agents Phase 4
31 Cytochrome P-450 Enzyme Inhibitors Phase 4
32 Respiratory System Agents Phase 4
33 Acetaminophen, hydrocodone drug combination Phase 4
34 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
35 Muscarinic Antagonists Phase 4
36 Antimanic Agents Phase 4
37 Cholinergic Antagonists Phase 4
38 Antiparkinson Agents Phase 4
39 Ketorolac Tromethamine Phase 4
40 Antitussive Agents Phase 4
41 Gastrointestinal Agents Phase 4
42 Narcotics Phase 4
43 Adjuvants, Anesthesia Phase 4
44 Cathartics Phase 4
45 Laxatives Phase 4
46 Polyethylene glycol 3350 Phase 4
47 Glucagon-Like Peptide 1 Phase 4
48 Incretins Phase 4
49 Tranquilizing Agents Phase 4
50 Anti-Anxiety Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 834)
# Name Status NCT ID Phase Drugs
1 Preoperative Assessment of Colon Tumor: A Prospective, Blinded Study. Unknown status NCT00114829 Phase 4
2 A Phase II Study of Tegafur-Uracil as Maintenance Chemotherapy in Patients With Stage II Microsatellite-Stable or Low-Level Microsatellite-Instability Colon Cancer Unknown status NCT02887365 Phase 4 tegafur-uracil
3 Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery as Part of an Enhanced Recovery After Surgery Protocol: A Randomized Prospective Single- Center Trial. Unknown status NCT02958566 Phase 4 Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
4 Multicenter Asia Study in Adjuvant Treatment of Colon Cancer With OxaliplaTin/5FU-LV Completed NCT00263055 Phase 4 oxaliplatin
5 Compression Anastomosis: Initial Clinical Experience With the ColonRingTM Completed NCT01056913 Phase 4
6 Konzentrationen Von Ertapenem in Kolorektalem Gewebe Completed NCT00535652 Phase 4 Ertapenem
7 Effect of Postoperative Laxative on Bowel Function After Colonic Surgery Completed NCT00427492 Phase 4 Magnesia;Placebo
8 Tandem Colonoscopy Study of Narrow Band Imaging Versus White Light Examination to Compare Neoplasia Miss Rates Completed NCT00628147 Phase 4
9 An Open Label Study to Evaluate the Safety of Xeloda as Adjuvant Monotherapy in Patients Who Have Undergone Surgery for Colon Cancer, Dukes Stage C. Completed NCT00502671 Phase 4 capecitabine [Xeloda]
10 Open-label, Efficacy and Safety Study of Bevacizumab (Avastin®) in Combination With XELOX (Oxaliplatin Plus Xeloda®) for the First-line Treatment of Patients With Metastatic Cancer of the Colon or Rectum - 'OBELIX' Completed NCT00577031 Phase 4 bevacizumab [Avastin];Oxaliplatin;Xeloda
11 Effect of Intravenous Omega-3 Fatty Acids on the Perioperative Immune Response and Erythrocyte Function in Patients With Colon Cancer Completed NCT02231203 Phase 4 Omegaven;Placebo
12 An Expanded Access Program of AvastinTM (Bevacizumab) in Patients With Metastatic Cancer of the Colon or Rectum Completed NCT02582970 Phase 4 5-Fluorouracil;Bevacizumab;Irinotecan;Oxaliplatin
13 Role of Glucagon in Outpatient Colonoscopy? A Prospective Double-Blind Randomized Controlled Trial Completed NCT02078726 Phase 4 Glucagon;Placebo
14 Endo-Laparoscopic Approach Versus Conventional Open Surgery in the Management of Obstructing Left-sided Colon Cancer: A Randomized Trial Completed NCT00654212 Phase 4
15 Patient Satisfaction With Propofol for Out Patient Colonoscopy: A Prospective, Randomized, Double-Blind Study Completed NCT02937506 Phase 4 Propofol;Fentanyl Plus Midazolam
16 Clinical Efficacy of Chemotherapy Combined With Cytokine-induced Killer in Treatment of Patients With Colon Cancer Completed NCT03084809 Phase 4 Cytokine-induced killer cells+ FOLFOX4;FOLFOX4
17 Effects of Different Types of Perioperative Analgesia on Minimal Residual Disease Development After Colon Cancer Surgery Completed NCT02314871 Phase 4 Piritramide;Morphine
18 A Prospective, Randomized Controlled Trial Comparing the Efficacy and Patient Tolerability of Miralax (PEG 3350) vs. Golytely as Bowel Preparation for Screening Colonoscopy Completed NCT01170754 Phase 4 PEG-3350 and Gatorade;Golytely 4 liters
19 Preoperative Use of the High Protein ONS vs Immunoenhancing ONS in Gastrointestinal Cancer Patients Undergoing Surgery Recruiting NCT03980704 Phase 4 IMPACT;resource protein
20 A Randomized, Open-label Study to Compare Propofol Anesthesia With Sevoflurane Anesthesia in Terms of Overall Survival in Patients With Surgical Intervention for Either Breast-, Colon- or Rectal Cancer Recruiting NCT01975064 Phase 4 Propofol;Sevoflurane
21 Multicenter Randomized Study in Patients With Colorectal Cancer With Unresectable Metastases. Impact of Resection vs no Resection of the Primary Tumour as a Survival Factor Active, not recruiting NCT02015923 Phase 4 Chemotherapy- scheme
22 Complete Mesocolon Excision vs Locoregional Lymphadenectomy in Sigmoid Colon Cancer (CMELL) Not yet recruiting NCT03083951 Phase 4
23 Italian Multicenter Prospective Randomized Trial to Compare Additive Hemostatic Efficacy of EndoClot System to Prevent Bleeding After Endoscopic Mucosal Resection or Endoscopic Submucosal Dissection of Lesions in the Gastrointestinal Tract Not yet recruiting NCT02688699 Phase 4
24 Phase III Trial of Gemcitabine, Curcumin and Celebrex in Patients With Metastatic Colon Cancer Unknown status NCT00295035 Phase 3 CELECOXIB;CURCUMIN
25 A Randomized Clinical Trial Comparing Laparoscopic and Open Surgery for Colon Cancer Unknown status NCT00387842 Phase 3
26 A Multicenter Prospective Randomized Clinical Trail on the Efficacy of the Single Port Laparoscopic Surgery Compared With Multiport Laparoscopic Surgery Unknown status NCT01480128 Phase 3
27 Microbiological Spectrum of the Intraperitoneal Surface After Elective Right-sided Colon Cancer: Are There Differences in the Peritoneal Contamination After Performing a Stapled or a Handsewn Anastomosis? Unknown status NCT01458353 Phase 3
28 Immunotherapy of Colon Cancer With Autologous Perchloric Soluble Tumors Extracts Unknown status NCT00002455 Phase 3
29 Phase III Randomized Study of Intensive Adjuvant Chemotherapy for Resected Colon Cancer at High Risk of Recurrence Unknown status NCT00005979 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
30 The Role of Indocyanine Green (ICG) Fluorescence Imaging on Anastomotic Leak and Short-term Outcomes in Robotic Colorectal Surgery: A Prospective Randomized Trial Unknown status NCT02598414 Phase 2, Phase 3
31 The Influence of Micrometastases on Prognosis and Survival in Stage I-II Colon Cancer Patients: The EnRoute+ Study Unknown status NCT01097265 Phase 2, Phase 3 capecitabine;oxaliplatin
32 5-Fluorouracil-Leucovorin With or Without Carboplatin as Adjuvant Treatment for Primary Dukes B2-C Colon Cancer; Chronomodulated Versus Standard Administration. A Multicenter Randomized Phase III Trial of the GRECCR-Belgium (Study 03). Unknown status NCT00046995 Phase 3 carboplatin;fluorouracil;leucovorin calcium
33 Synergistic Anti-tumor Effect of ChangTai Keli Based on Chemotherapy for Colon Cancer Patients:a Randomized, Parallel-group, Double-blind, Multicenter Clinical Study Unknown status NCT02510118 Phase 2, Phase 3 mFOLFOX6;XELOX;Placebo ChangTai Keli;ChangTai Keli
34 Randomized Phase III Intergroup Trial in Resected Stage 2 (Dukes B) Colon Cancer: 6-Month Infusional 5FU-CPT11 (+/- Folinic Acid) Versus Observation - Determination of Biologic Predictive and Response Factors Unknown status NCT00091312 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
35 A Multicenter Trial Investigating the Duration of Adjuvant Therapy(3 vs. 6 Months) With the FOLFOX 4 or XELOX Regimen for Patients With High Risk Stage II or Stage III Colon Cancer Unknown status NCT01308086 Phase 3 5-Fluorouracil;Leucovorin;Oxaliplatin;Capecitabine;Oxaliplatin;5-Fluorouracil;Leucovorin;Capecitabine;Oxaliplatin;Oxaliplatin
36 A Phase III Randomized Trial Investigating the Duration of Adjuvant Therapy(3 Versus 6 Months) With the Modified FOLFOX 6 or XELOX Regimens for Patients With Stage III Colon Cancer Unknown status NCT00958737 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin;XELOX regimen;Capecitabine
37 Randomized Phase III Study Assessing the Interest of Primary Tumor Resection in Patients With Asymptomatic Colon Cancer and Unresectable Synchronous Liver Metastases. Unknown status NCT02363049 Phase 3 Chemotherapy
38 A Randomized Controlled Trial Comparing the Outcomes of Patients Who Undergo Single Port Laparoscopic Colectomy and Conventional Laparoscopic Colectomy for Colonic Neoplasia Unknown status NCT01101672 Phase 2, Phase 3
39 Multicenter International Study of Oxaliplatin/ 5FU-LV in the Adjuvant Treatment of Colon Cancer Completed NCT00275210 Phase 3 Oxaliplatin (SR96669)
40 BLI850 vs an Active Control Bowel Preparation in Adult Subjects Undergoing Colonoscopy Completed NCT00756977 Phase 3 BLI850;polyethylene glycol 3350 based bowel preparation
41 BLI850-302: BLI850 vs an Approved Active Control Bowel Preparation in Adult Subjects Undergoing Colonoscopy Completed NCT00756548 Phase 3 BLI850;polyethylene glycol 3350 based bowel preparation
42 Post-Approved Phase III Study of 1-LV/5FU Therapy Completed NCT00195585 Phase 3 Isovorin;UFT
43 A Prospectively Randomized Study on Adjuvant Chemotherapy in Patients With Operated Colon Carcinoma Dukes B (Stage II; T3-4, N0, M0). Completed NCT00309543 Phase 3 Fluorouracil;Leucovorin
44 The Effects of Exercise Training on the Health-related Fitness of Colon Cancer Survivors: a Randomized Controlled Trial Completed NCT00813540 Phase 2, Phase 3
45 A Prospectively Randomized Phase III Study on Adjuvant Chemotherapy and Adjuvant Chemo-Immunotherapy in Patients With Operated Colon Carcinoma Dukes C (Stage III; T1-4, N1-30, M0). Completed NCT00309530 Phase 3 5-fluorouracil, levamisol, interferon
46 A Randomized, Double-blind, Placebo-controlled, Phase Lll Study in Patients With Metastatic Adenocarcinoma of the Colon or Rectum Who Are Receiving First-line Chemotherapy With Oxaliplatin/5-fluorouracil/Leucovorin With PTK787/ZK 222584 or Placebo Completed NCT00056459 Phase 3 Vatalanib
47 A Randomized, Double-blind, Placebo-controlled, Phase III Study of Oxaliplatin/5-fluorouracil/Leucovorin With PTK787/ZK 222584 or Placebo in Patients With Previously Treated Metastatic Adenocarcinoma of the Colon or Rectum Completed NCT00056446 Phase 3 Vatalanib
48 Prophylactic Oophorectomy Followed by Chemotherapy Versus Chemotherapy Alone in Colorectal Patients With or Without Ovarian Metastasis Completed NCT01483443 Phase 3
49 A Double Blind, Placebo Controlled Pivotal Phase III Study Evaluating Xilonix™ in Symptomatic Colorectal Cancer Patients Refractory to Standard Therapy Completed NCT02138422 Phase 3
50 First-Line Bevacizumab and Chemotherapy in Metastatic Cancer of the Colon or Rectum First BEAT (Bevacizumab Expanded Access Trial)- Brazilian Extension Completed NCT01169558 Phase 3 Bevacizumab;Fluoropyrimidine-based Chemotherapy

Search NIH Clinical Center for Colonic Benign Neoplasm

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Carmustine
Fluorouracil
irinotecan
Irinotecan hydrochloride
Levamisole
Lomustine

Genetic Tests for Colonic Benign Neoplasm

Genetic tests related to Colonic Benign Neoplasm:

# Genetic test Affiliating Genes
1 Neoplasm of the Colon 29

Anatomical Context for Colonic Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Colonic Benign Neoplasm:

19
Colon

MalaCards organs/tissues related to Colonic Benign Neoplasm:

41
Colon, Liver, Testes, Lung, Breast, Lymph Node, Skin

Publications for Colonic Benign Neoplasm

Articles related to Colonic Benign Neoplasm:

(show all 19)
# Title Authors PMID Year
1
Gastrointestinal complications and extraintestinal manifestations of inflammatory bowel disease in Taiwan: A population-based study. 38
27838292 2017
2
Impact of procedure on the post-operative infection risk of patients after elective colon surgery. 38
25401415 2014
3
[Turcot syndrome. Rare observation and literature review]. 38
23866578 2013
4
[Adenocarcinoid neoplasm of the colon. Case report]. 38
23234749 2012
5
Incidence of colorectal cancer in Poland in 1999-2008. 38
22291804 2011
6
[Complications of distal intestinal occlusion treatment with endoluminal implants]. 38
21640986 2011
7
Primary sclerosing cholangitis and extraintestinal manifestations in patients with ulcerative colitis and ileal pouch-anal anastomosis. 38
20480253 2010
8
Perivascular epithelioid cell neoplasm of the colon. 38
21160599 2010
9
A palpable, obstructing carcinoma of the colon incarcerated within a large ventral hernia. 38
16843881 2006
10
[Proctological diseases in routine urologic practice]. 38
14579848 2003
11
Patients with multiple myeloma and solid tumors: six case reports. 38
9700587 1998
12
[Colonic tumors: experience at a clinical center in Caracas]. 38
7926615 1994
13
[Laparoscopic-assisted colectomy]. 38
8144081 1994
14
[Neoplasm of the colon and Barrett esophagus]. 38
2813916 1989
15
Psoas abscess demonstrated by CT as the first evidence of carcinoma of the colon. 38
3436132 1987
16
[Carcinoma of the endometrium, neoplasm of the colon and adenocarcinoma of the rectum in the same patient]. 38
3738055 1986
17
[Neoplasm of the colon. Clinical and therapeutic considerations on 80 cases]. 38
6062635 1967
18
[Pseudo-neoplasm of the colon of amebic etiology]. 38
14956115 1952
19
TESTS OF HEPATIC FUNCTION IN CARCINOMA; THEIR VALUE IN CASES OF NEOPLASM OF THE COLON WITH AND WITHOUT METASTASIS TO THE LIVER. 38
17866259 1930

Variations for Colonic Benign Neoplasm

ClinVar genetic disease variations for Colonic Benign Neoplasm:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 BRAF NM_004333.6(BRAF): c.1799T> A (p.Val600Glu) single nucleotide variant Pathogenic rs113488022 7:140453136-140453136 7:140753336-140753336
2 BRAF NM_004333.6(BRAF): c.1799_1800delinsAA (p.Val600Glu) indel Likely pathogenic rs121913377 7:140453135-140453136 7:140753335-140753336
3 ERBB3 NM_001982.3(ERBB3): c.850G> A (p.Gly284Arg) single nucleotide variant Likely pathogenic rs1057519803 12:56481922-56481922 12:56088138-56088138
4 TP53 NM_000546.5(TP53): c.1060C> A (p.Gln354Lys) single nucleotide variant Uncertain significance rs755394212 17:7573967-7573967 17:7670649-7670649

Expression for Colonic Benign Neoplasm

Search GEO for disease gene expression data for Colonic Benign Neoplasm.

Pathways for Colonic Benign Neoplasm

Pathways related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.02 TP53 KRAS HRAS CTNNB1 CDX2 BRAF
2
Show member pathways
12.97 TP53 PTGS2 KRAS HRAS CTNNB1 CCND1
3
Show member pathways
12.95 TP53 PTGS2 KRAS HRAS CTNNB1 CCND1
4
Show member pathways
12.91 TP53 PTGS2 MSH2 MLH1 KRAS HRAS
5
Show member pathways
12.87 PTGS2 KRAS HRAS CTNNB1 CCND1 BRAF
6
Show member pathways
12.77 TP53 MSH2 MLH1 KRAS HRAS CTNNB1
7
Show member pathways
12.7 TP53 KRAS HRAS CCND1 BRAF
8
Show member pathways
12.67 TP53 PTGS2 KRAS HRAS CTNNB1 BRAF
9
Show member pathways
12.59 TP53 MSH2 KRAS HRAS CTNNB1
10
Show member pathways
12.58 TP53 MLH1 KRAS HRAS CTNNB1 CDX2
11
Show member pathways
12.56 TP53 KRAS HRAS CCND1 BRAF
12 12.52 TP53 PTGS2 KRAS HRAS CCND1 APC
13 12.51 TP53 MSH2 MLH1 CCND1
14
Show member pathways
12.48 TP53 LGR5 KRAS HRAS BRAF APC
15
Show member pathways
12.46 TP53 LGR5 CTNNB1 APC
16
Show member pathways
12.45 TP53 KRAS HRAS CTNNB1
17
Show member pathways
12.43 PTGS2 KRAS HRAS BRAF
18
Show member pathways
12.41 KRAS HRAS CTNNB1 BRAF APC
19 12.4 TP53 PTGS2 CTNNB1 CCND1 APC
20 12.38 TP53 PTGS2 MSH2 MLH1 KRAS HRAS
21
Show member pathways
12.36 PTGS2 KRAS HRAS CTNNB1 BRAF
22 12.33 TP53 KRAS HRAS CTNNB1 CCND1 APC
23 12.31 TP53 KRAS HRAS CCND1
24
Show member pathways
12.29 TP53 CTNNB1 CCND1 APC
25
Show member pathways
12.28 TP53 KRAS HRAS BRAF
26 12.24 TP53 KRAS HRAS CTNNB1 CCND1 BRAF
27
Show member pathways
12.21 KRAS HRAS CTNNB1 CCND1
28 12.18 TP53 KRAS HRAS CCND1
29
Show member pathways
12.18 TP53 KRAS HRAS BRAF
30
Show member pathways
12.18 TP53 KRAS HRAS CCND1 BRAF
31 12.15 TP53 KRAS HRAS CCND1
32
Show member pathways
12.15 TP53 KRAS HRAS BRAF
33 12.1 KRAS HRAS CTNNB1 APC
34
Show member pathways
12.08 KRAS HRAS CCND1 BRAF
35 12.06 TP53 MSH2 MLH1 APC
36 12.05 TP53 ODC1 MSH2 KRAS CTNNB1 CCND1
37 12.01 KRAS HRAS CTNNB1 APC
38 12 TP53 KRAS HRAS CTNNB1 CCND1
39 11.98 TP53 PTGS2 CCND1
40 11.98 PTGS2 KRAS HRAS BRAF
41 11.97 KRAS HRAS BRAF
42
Show member pathways
11.97 TP53 PTGS2 CTNNB1 CCND1 APC
43 11.94 TP53 HRAS BRAF
44 11.94 TP53 KRAS HRAS CTNNB1 CCND1 APC
45 11.91 KRAS HRAS CCND1
46 11.87 TP53 PTGS2 CCND1
47
Show member pathways
11.82 KRAS HRAS BRAF
48 11.8 CTNNB1 CCND1 APC
49 11.76 TP53 MSH2 MLH1
50 11.75 TP53 KRAS HRAS CTNNB1 CCND1 BRAF

GO Terms for Colonic Benign Neoplasm

Cellular components related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 9.16 MSH2 MLH1
2 beta-catenin destruction complex GO:0030877 8.96 CTNNB1 APC
3 Wnt signalosome GO:1990909 8.62 CTNNB1 APC

Biological processes related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.97 TP53 PTGS2 CTNNB1 CEACAM5 BRAF
2 cellular response to DNA damage stimulus GO:0006974 9.92 TP53 MSH2 MLH1 CCND1 APC
3 cytokine-mediated signaling pathway GO:0019221 9.89 TP53 PTGS2 KRAS CCND1
4 negative regulation of cell proliferation GO:0008285 9.89 TP53 PTGS2 HRAS CTNNB1 APC
5 positive regulation of apoptotic process GO:0043065 9.8 TP53 PTGS2 HPGD CTNNB1 APC
6 kidney development GO:0001822 9.79 ODC1 HPGD CTNNB1
7 regulation of cell proliferation GO:0042127 9.76 PTGS2 LGR5 CTNNB1 BRAF
8 Ras protein signal transduction GO:0007265 9.72 TP53 KRAS HRAS
9 response to glucocorticoid GO:0051384 9.71 PTGS2 KRAS CCND1
10 negative regulation of neuron apoptotic process GO:0043524 9.67 MSH2 KRAS HRAS BRAF
11 somatic hypermutation of immunoglobulin genes GO:0016446 9.63 MSH2 MLH1
12 epithelial tube branching involved in lung morphogenesis GO:0060441 9.62 KRAS CTNNB1
13 cell cycle arrest GO:0007050 9.62 TP53 MSH2 HRAS APC
14 isotype switching GO:0045190 9.61 MSH2 MLH1
15 lipoxygenase pathway GO:0019372 9.61 PTGS2 HPGD
16 determination of adult lifespan GO:0008340 9.6 TP53 MSH2
17 ovulation GO:0030728 9.58 PTGS2 HPGD
18 positive regulation of isotype switching to IgG isotypes GO:0048304 9.57 MSH2 MLH1
19 mitotic G1 DNA damage checkpoint GO:0031571 9.56 TP53 CCND1
20 response to isolation stress GO:0035900 9.51 KRAS HRAS
21 positive regulation of isotype switching to IgA isotypes GO:0048298 9.48 MSH2 MLH1
22 response to estradiol GO:0032355 9.46 PTGS2 HPGD CTNNB1 CCND1
23 somatic recombination of immunoglobulin gene segments GO:0016447 9.43 MSH2 MLH1
24 positive regulation of gene expression GO:0010628 9.43 TP53 KRAS KDM4C HRAS CTNNB1 BRAF
25 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.26 MSH2 MLH1
26 positive regulation of cell proliferation GO:0008284 9.23 PTGS2 ODC1 KRAS KDM4C HRAS CTNNB1

Molecular functions related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.65 TP53 MSH2 CTNNB1 CCND1 APC
2 chromatin binding GO:0003682 9.35 TP53 MSH2 MLH1 KDM4C CTNNB1
3 mismatched DNA binding GO:0030983 9.32 MSH2 MLH1
4 enzyme binding GO:0019899 9.17 TP53 PTGS2 MSH2 MLH1 KDM4C CTNNB1
5 guanine/thymine mispair binding GO:0032137 9.16 MSH2 MLH1

Sources for Colonic Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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