MCID: CLN045
MIFTS: 48

Colonic Benign Neoplasm

Categories: Cancer diseases, Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Colonic Benign Neoplasm

MalaCards integrated aliases for Colonic Benign Neoplasm:

Name: Colonic Benign Neoplasm 12 15
Neoplasm of the Colon 6
Neoplasm of Colon 12
Colonic Neoplasms 70
Colon Neoplasm 12
Colonic Tumor 12
Colonic Mass 12

Classifications:



External Ids:

Disease Ontology 12 DOID:235
MeSH 44 D003110
NCIt 50 C2953
SNOMED-CT 67 126838000
UMLS 70 C0009375

Summaries for Colonic Benign Neoplasm

Disease Ontology : 12 An intestinal benign neoplasm that is located in the colon.

MalaCards based summary : Colonic Benign Neoplasm, also known as neoplasm of the colon, is related to colon adenoma and familial adenomatous polyposis 2. An important gene associated with Colonic Benign Neoplasm is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are ERK Signaling and PI3K-Akt signaling pathway. The drugs Guaifenesin and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and lymph node, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Related Diseases for Colonic Benign Neoplasm

Diseases related to Colonic Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 477)
# Related Disease Score Top Affiliating Genes
1 colon adenoma 32.0 MIR18A MIR15A MIR143 LGR5 KRAS CTNNB1
2 familial adenomatous polyposis 2 30.9 PTGS2 MLH1 APC
3 hepatic flexure cancer 30.8 KRAS HRAS
4 serrated polyposis syndrome 30.8 KRAS BRAF APC
5 juvenile polyposis syndrome 30.6 PTGS2 MLH1 APC
6 descending colon cancer 30.6 KRAS HRAS CEACAM5 CDX2
7 transverse colon cancer 30.6 MLH1 KRAS HRAS CEACAM5
8 cecum carcinoma 30.5 MLH1 KRAS HRAS CEACAM5
9 appendix cancer 30.4 TP53 KRAS HRAS CEACAM5 CDX2
10 ascending colon cancer 30.4 MLH1 KRAS HRAS CEACAM5 CDX2
11 gastrointestinal stromal tumor 30.3 TP53 PTGS2 KRAS BRAF APC
12 barrett esophagus 30.3 TP53 PTGS2 CTNNB1 CDX2 APC
13 colitis 30.3 PTGS2 MLH1 CTNNB1 CCR6 BRAF
14 histiocytosis 30.3 SERPINA3 CCR6 BRAF
15 sarcoma 30.2 TP53 PTGS2 KRAS HRAS CTNNB1 BRAF
16 gastrointestinal carcinoma 30.1 TP53 CEACAM5 CDX2
17 large intestine cancer 30.0 SERPINA3 MIR20A MIR18A MIR15A MIR143 KRAS
18 colon adenocarcinoma 29.7 TP53 PTGS2 MLH1 KRAS CTNNB1 CEACAM5
19 villous adenoma 29.7 TP53 MLH1 KRAS HRAS CEACAM5 CDX2
20 renal cell carcinoma, nonpapillary 29.6 TP53 MIR18A MIR15A MIR143 KDM4C HRAS
21 myeloma, multiple 29.6 TP53 MIR15A KRAS KDM4C HRAS H2AC18
22 adenocarcinoma 29.6 TP53 PTGS2 MLH1 KRAS HRAS ERBB3
23 endometrial cancer 29.6 TP53 SERPINA3 MLH1 KRAS HRAS CTNNB1
24 colorectal adenocarcinoma 29.3 TP53 PTGS2 MLH1 LGR5 KRAS HRAS
25 lung cancer susceptibility 3 29.1 TP53 PTGS2 MLH1 MIR15A KRAS HRAS
26 colorectal cancer 28.9 TP53 SERPINA3 PTGS2 MLH1 MIR20A MIR18A
27 neuroendocrine tumor of the colon 11.2
28 colon squamous cell carcinoma 10.5
29 nevus of ota 10.5 TP53 BRAF
30 trachea carcinoma in situ 10.5 KRAS HRAS
31 cobblestone retinal degeneration 10.5 KRAS HRAS
32 apocrine adenoma 10.5 KRAS BRAF
33 familial colorectal cancer type x 10.5
34 classic pulmonary blastoma 10.5 CTNNB1 CEACAM5
35 vulvar intraepithelial neoplasia 10.5 TP53 CTNNB1
36 acneiform dermatitis 10.5 KRAS HRAS BRAF
37 mucinous lung adenocarcinoma 10.5 KRAS HRAS ERBB3
38 ethmoid sinus cancer 10.5 HRAS CDX2
39 mucoepidermoid esophageal carcinoma 10.5 TP53 CEACAM5
40 spitz nevus 10.5 TP53 HRAS BRAF
41 syringocystadenoma papilliferum 10.5 SERPINA3 KRAS BRAF
42 paronychia 10.5 KRAS HRAS ERBB3
43 ampulla of vater benign neoplasm 10.5 KRAS HRAS APC
44 periampullary adenoma 10.5 KRAS HRAS APC
45 pancreatic cystadenocarcinoma 10.5 KRAS CEACAM5
46 gallbladder papillary carcinoma 10.4 PTGS2 CEACAM5
47 pancreatic signet ring cell adenocarcinoma 10.4 TP53 KRAS HRAS
48 myh-associated polyposis 10.4 KRAS HRAS APC
49 nodular malignant melanoma 10.4 TP53 HRAS BRAF
50 colorectal cancer, hereditary nonpolyposis, type 5 10.4 MLH1 BRAF APC

Graphical network of the top 20 diseases related to Colonic Benign Neoplasm:



Diseases related to Colonic Benign Neoplasm

Symptoms & Phenotypes for Colonic Benign Neoplasm

MGI Mouse Phenotypes related to Colonic Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 APC BRAF CCR6 CDX2 CTNNB1 ERBB3
2 endocrine/exocrine gland MP:0005379 10.23 APC BRAF CDX2 CTNNB1 ERBB3 HRAS
3 digestive/alimentary MP:0005381 10.22 APC BRAF CDX2 CTNNB1 ERBB3 HRAS
4 integument MP:0010771 10.18 APC BRAF CTNNB1 ERBB3 HRAS KDM4C
5 neoplasm MP:0002006 10.1 APC BRAF CDX2 CTNNB1 ERBB3 HRAS
6 muscle MP:0005369 9.97 APC BRAF CTNNB1 ERBB3 HRAS KRAS
7 normal MP:0002873 9.96 APC BRAF CCR6 CDX2 CTNNB1 ERBB3
8 pigmentation MP:0001186 9.63 APC BRAF CTNNB1 ERBB3 KRAS TP53
9 renal/urinary system MP:0005367 9.56 APC BRAF CTNNB1 HRAS KRAS LGR5
10 respiratory system MP:0005388 9.28 BRAF CTNNB1 ERBB3 HRAS KRAS LGR5

Drugs & Therapeutics for Colonic Benign Neoplasm

Drugs for Colonic Benign Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 397)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
2
Acetaminophen Approved Phase 4 103-90-2 1983
3
Methadone Approved Phase 4 76-99-3 4095
4
Phenylpropanolamine Approved, Vet_approved, Withdrawn Phase 4 14838-15-4 26934
5
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
6
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
7
Orphenadrine Approved Phase 4 83-98-7 4601
8
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
9
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
10
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
11
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
12
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
13
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
14
Magnesium oxide Approved Phase 4 1309-48-4 14792
15
Glucagon Approved Phase 4 16941-32-5
16
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
17
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
18
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
19
Panitumumab Approved, Investigational Phase 4 339177-26-3 50070211
20 Acetaminophen, hydrocodone drug combination Phase 4
21 Respiratory System Agents Phase 4
22 Excitatory Amino Acid Antagonists Phase 4
23 Cytochrome P-450 Enzyme Inhibitors Phase 4
24 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
25 Muscarinic Antagonists Phase 4
26 Anticonvulsants Phase 4
27 Cholinergic Agents Phase 4
28 Anesthetics, Dissociative Phase 4
29 Antitussive Agents Phase 4
30 Ketorolac Tromethamine Phase 4
31 Cholinergic Antagonists Phase 4
32 Antiparkinson Agents Phase 4
33 Hemostatics Phase 4
34 Narcotics Phase 4
35 Analgesics, Opioid Phase 4
36 Gastrointestinal Agents Phase 4
37 Hormone Antagonists Phase 4
38 Hormones Phase 4
39 Polyethylene glycol 3350 Phase 4
40 Anti-Infective Agents Phase 4
41 Anti-Bacterial Agents Phase 4
42 Psychotropic Drugs Phase 4
43 Neurotransmitter Agents Phase 4
44 Anti-Anxiety Agents Phase 4
45 Pirinitramide Phase 4
46 GABA Modulators Phase 4
47 Glucagon-Like Peptide 1 Phase 4
48 Hypnotics and Sedatives Phase 4
49 Anesthetics, General Phase 4
50 Anesthetics, Intravenous Phase 4

Interventional clinical trials:

(show top 50) (show all 844)
# Name Status NCT ID Phase Drugs
1 Preoperative Assessment of Colon Tumor: A Prospective, Blinded Study. Unknown status NCT00114829 Phase 4
2 Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery as Part of an Enhanced Recovery After Surgery Protocol: A Randomized Prospective Single- Center Trial. Unknown status NCT02958566 Phase 4 Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
3 A Phase II Study of Tegafur-Uracil as Maintenance Chemotherapy in Patients With Stage II Microsatellite-Stable or Low-Level Microsatellite-Instability Colon Cancer Unknown status NCT02887365 Phase 4 tegafur-uracil
4 Italian Multicenter Prospective Randomized Trial to Compare Additive Hemostatic Efficacy of EndoClot System to Prevent Bleeding After Endoscopic Mucosal Resection or Endoscopic Submucosal Dissection of Lesions in the Gastrointestinal Tract Unknown status NCT02688699 Phase 4
5 Tandem Colonoscopy Study of Narrow Band Imaging Versus White Light Examination to Compare Neoplasia Miss Rates Completed NCT00628147 Phase 4
6 Compression Anastomosis: Initial Clinical Experience With the ColonRingTM Completed NCT01056913 Phase 4
7 Multicenter Asia Study in Adjuvant Treatment of Colon Cancer With OxaliplaTin/5FU-LV Completed NCT00263055 Phase 4 oxaliplatin
8 Endo-Laparoscopic Approach Versus Conventional Open Surgery in the Management of Obstructing Left-sided Colon Cancer: A Randomized Trial Completed NCT00654212 Phase 4
9 Effect of Intravenous Omega-3 Fatty Acids on the Perioperative Immune Response and Erythrocyte Function in Patients With Colon Cancer Completed NCT02231203 Phase 4 Omegaven;Placebo
10 An Open Label Study to Evaluate the Safety of Xeloda as Adjuvant Monotherapy in Patients Who Have Undergone Surgery for Colon Cancer, Dukes Stage C. Completed NCT00502671 Phase 4 capecitabine [Xeloda]
11 A Prospective, Randomized Controlled Trial Comparing the Efficacy and Patient Tolerability of Miralax (PEG 3350) vs. Golytely as Bowel Preparation for Screening Colonoscopy Completed NCT01170754 Phase 4 PEG-3350 and Gatorade;Golytely 4 liters
12 Effects of Different Types of Perioperative Analgesia on Minimal Residual Disease Development After Colon Cancer Surgery Completed NCT02314871 Phase 4 Piritramide;Morphine
13 Effect of Postoperative Laxative on Bowel Function After Colonic Surgery Completed NCT00427492 Phase 4 Magnesia;Placebo
14 Open-label, Efficacy and Safety Study of Bevacizumab (Avastin®) in Combination With XELOX (Oxaliplatin Plus Xeloda®) for the First-line Treatment of Patients With Metastatic Cancer of the Colon or Rectum - 'OBELIX' Completed NCT00577031 Phase 4 bevacizumab [Avastin];Oxaliplatin;Xeloda
15 An Expanded Access Program of AvastinTM (Bevacizumab) in Patients With Metastatic Cancer of the Colon or Rectum Completed NCT02582970 Phase 4 5-Fluorouracil;Bevacizumab;Irinotecan;Oxaliplatin
16 Patient Satisfaction With Propofol for Out Patient Colonoscopy: A Prospective, Randomized, Double-Blind Study Completed NCT02937506 Phase 4 Propofol;Fentanyl Plus Midazolam
17 Role of Glucagon in Outpatient Colonoscopy? A Prospective Double-Blind Randomized Controlled Trial Completed NCT02078726 Phase 4 Glucagon;Placebo
18 Konzentrationen Von Ertapenem in Kolorektalem Gewebe Completed NCT00535652 Phase 4 Ertapenem
19 Preoperative Use of the High Protein ONS vs Immunoenhancing ONS in Gastrointestinal Cancer Patients Undergoing Surgery Recruiting NCT03980704 Phase 4 IMPACT;resource protein
20 A Randomized, Open-label Study to Compare Propofol Anesthesia With Sevoflurane Anesthesia in Terms of Overall Survival in Patients With Surgical Intervention for Either Breast-, Colon- or Rectal Cancer Recruiting NCT01975064 Phase 4 Propofol;Sevoflurane
21 Multicenter Randomized Study in Patients With Colorectal Cancer With Unresectable Metastases. Impact of Resection vs no Resection of the Primary Tumour as a Survival Factor Terminated NCT02015923 Phase 4 Chemotherapy- scheme
22 A Randomized Clinical Trial Comparing Laparoscopic and Open Surgery for Colon Cancer Unknown status NCT00387842 Phase 3
23 Phase III Trial of Gemcitabine, Curcumin and Celebrex in Patients With Metastatic Colon Cancer Unknown status NCT00295035 Phase 3 CELECOXIB;CURCUMIN
24 The Role of Indocyanine Green (ICG) Fluorescence Imaging on Anastomotic Leak and Short-term Outcomes in Robotic Colorectal Surgery: A Prospective Randomized Trial Unknown status NCT02598414 Phase 2, Phase 3
25 Assessing How the Viscosity of Submucosal Gel Injections Helps With Endoscopic Mucosal Resections Unknown status NCT02519140 Phase 3 Cook Medical EMR Gel
26 Synergistic Anti-tumor Effect of ChangTai Keli Based on Chemotherapy for Colon Cancer Patients:a Randomized, Parallel-group, Double-blind, Multicenter Clinical Study Unknown status NCT02510118 Phase 2, Phase 3 mFOLFOX6;XELOX;Placebo ChangTai Keli;ChangTai Keli
27 Pilot / Phase III Randomized Trial Comparing Standard Systemic Therapy to Cytoreduction + Hyperthermic Intraperitoneal Mitomycin C + Standard Systemic Therapy in Patients With Limited Peritoneal Dissemination of Colon Adenocarcinoma Unknown status NCT01167725 Phase 3 FOLFIRI regimen;FOLFOX regimen;capecitabine;fluorouracil;irinotecan hydrochloride;leucovorin calcium;mitomycin C;oxaliplatin
28 Randomized Phase III Study Assessing the Interest of Primary Tumor Resection in Patients With Asymptomatic Colon Cancer and Unresectable Synchronous Liver Metastases. Unknown status NCT02363049 Phase 3 Chemotherapy
29 5-Fluorouracil-Leucovorin With or Without Carboplatin as Adjuvant Treatment for Primary Dukes B2-C Colon Cancer; Chronomodulated Versus Standard Administration. A Multicenter Randomized Phase III Trial of the GRECCR-Belgium (Study 03). Unknown status NCT00046995 Phase 3 carboplatin;fluorouracil;leucovorin calcium
30 Immunotherapy of Colon Cancer With Autologous Perchloric Soluble Tumors Extracts Unknown status NCT00002455 Phase 3
31 Complete Mesocolic Excision (CME) With Central Supplying Vessel Ligation (CVL) Compared With Conventional Surgery for Colon Cancer: a Double-blinded Randomized Study Unknown status NCT02526836 Phase 2, Phase 3
32 A Randomized Controlled Trial Comparing the Outcomes of Patients Who Undergo Single Port Laparoscopic Colectomy and Conventional Laparoscopic Colectomy for Colonic Neoplasia Unknown status NCT01101672 Phase 2, Phase 3
33 Randomized Phase III Intergroup Trial in Resected Stage 2 (Dukes B) Colon Cancer: 6-Month Infusional 5FU-CPT11 (+/- Folinic Acid) Versus Observation - Determination of Biologic Predictive and Response Factors Unknown status NCT00091312 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
34 Microbiological Spectrum of the Intraperitoneal Surface After Elective Right-sided Colon Cancer: Are There Differences in the Peritoneal Contamination After Performing a Stapled or a Handsewn Anastomosis? Unknown status NCT01458353 Phase 3
35 The Effectiveness and Safety of Adjuvant Cytokine-induced Killer Cell Immunotherapy for Stage III Colorectal Cancer Patients After Chemotherapy Unknown status NCT02280278 Phase 3 Adjuvant chemotherapy
36 The Influence of Micrometastases on Prognosis and Survival in Stage I-II Colon Cancer Patients: The EnRoute+ Study Unknown status NCT01097265 Phase 2, Phase 3 capecitabine;oxaliplatin
37 A RANDOMIZED, CONTROLLED, CLINICAL TRIAL TO COMPARE PERIPHERAL PARENTERAL NUTRITION (PeriOlimel N4-E) VERSUS CONVENTIONAL FLUID THERAPY IN ENHANCED RECOVERY AFTER SURGERY (ERAS) PROTOCOL IN COLORECTAL CANCER SURGERY. Unknown status NCT03606863 Phase 3 Perioperative peripheral parenteral nutrition
38 A Multicenter Trial Investigating the Duration of Adjuvant Therapy(3 vs. 6 Months) With the FOLFOX 4 or XELOX Regimen for Patients With High Risk Stage II or Stage III Colon Cancer Unknown status NCT01308086 Phase 3 5-Fluorouracil;Leucovorin;Oxaliplatin;Capecitabine;Oxaliplatin;5-Fluorouracil;Leucovorin;Capecitabine;Oxaliplatin;Oxaliplatin
39 A Phase III Randomized Trial Investigating the Duration of Adjuvant Therapy(3 Versus 6 Months) With the Modified FOLFOX 6 or XELOX Regimens for Patients With Stage III Colon Cancer Unknown status NCT00958737 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin;XELOX regimen;Capecitabine
40 Multicenter International Study of Oxaliplatin/ 5FU-LV in the Adjuvant Treatment of Colon Cancer Completed NCT00275210 Phase 3 Oxaliplatin (SR96669)
41 The Effects of Exercise Training on the Health-related Fitness of Colon Cancer Survivors: a Randomized Controlled Trial Completed NCT00813540 Phase 2, Phase 3
42 Parallel Group Comparison of the New 2 Liter Gut Cleansing Solution NRL 994 Versus Sodium Phosphate Preparation in Routine Colon Cleansing Prior to Colonoscopies for Colon Tumor Screening. Completed NCT00427089 Phase 3 Macrogol 3350 Na sulphate NaCl KCl Ascorbic Acid Na Ascorbate;Sodium Phosphate solution (NaP)
43 A Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Palifermin (Recombinant Human Keratinocyte Growth Factor) for Reduction of Oral Mucositis in Subjects With Stage 2B or 3 Locally Advanced, Colon Cancer Receiving 5-FU and Leucovorin as Adjuvant Therapy Completed NCT00393822 Phase 2, Phase 3 palifermin;placebo
44 Adjuvant Treatment of Fully Resected Stage III Colon Cancer With FOLFOX-4 Versus FOLFOX-4 Plus Cetuximab Completed NCT00265811 Phase 3 Folfox;Cetuximab
45 A Randomized Trial of Cancer Risk and Health Education in Relatives of Colorectal Cancer Patients Completed NCT00188305 Phase 3
46 A Phase III Clinical Trial Comparing Infusional 5-Fluorouracil (5-FU), Leucovorin, and Oxaliplatin (mFOLFOX6) Every Two Weeks With Bevacizumab to the Same Regimen Without Bevacizumab for the Treatment of Patients With Resected Stages II and III Carcinoma of the Colon Completed NCT00096278 Phase 3 Fluorouracil;Leucovorin Calcium;Oxaliplatin
47 Prevention of Sporadic Colorectal Adenomas With Celecoxib Completed NCT00005094 Phase 3 celecoxib
48 A Clinical Trial Comparing 5-Fluorouracil (5-FU) Plus Leucovorin (LV) and Oxaliplatin With 5-FU Plus LV for the Treatment of Patients With Stages II and III Carcinoma of the Colon Completed NCT00004931 Phase 3 leucovorin calcium;fluorouracil;oxaliplatin
49 A Randomized Phase III Equivalence Trial of Irinotecan (CPT-11) Versus Oxaliplatin (OXAL)/5-Fluorouracil (5-FU)/Leucovorin (CF) in Patients With Advanced Colorectal Carcinoma Previously Treated With 5-FU Completed NCT00005036 Phase 3 irinotecan hydrochloride;oxaliplatin;leucovorin calcium;fluorouracil
50 Phase III Randomized Trial of 5-FU/Leucovorin/Levamisole Versus 5-FU Continuous Infusion/Levamisole as Adjuvant Therapy for High-Risk Resectable Colon Cancer Completed NCT00002593 Phase 3 fluorouracil;leucovorin calcium;levamisole hydrochloride

Search NIH Clinical Center for Colonic Benign Neoplasm

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Carmustine
Fluorouracil
irinotecan
Irinotecan hydrochloride
Levamisole
Lomustine

Genetic Tests for Colonic Benign Neoplasm

Anatomical Context for Colonic Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Colonic Benign Neoplasm:

19
Colon

MalaCards organs/tissues related to Colonic Benign Neoplasm:

40
Colon, Liver, Lymph Node, Skin, Thyroid, Spleen, Kidney

Publications for Colonic Benign Neoplasm

Articles related to Colonic Benign Neoplasm:

(show all 26)
# Title Authors PMID Year
1
Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 6
25157968 2014
2
Oncogenic ERBB3 mutations in human cancers. 6
23680147 2013
3
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. 6
22281684 2012
4
Unusual Case of Gallbladder Adenocarcinoma Metastasis to the Abdominal Wall 11 Years Later: Synchronous Presentation with Two Malignant Colon Tumors, Coincidence or Not? 61
33728090 2021
5
Successful Treatment of a Mixed Neuroendocrine-Nonneuroendocrine Neoplasm of the Colon with Metastases to the Thyroid Gland and Liver. 61
32099708 2020
6
IMFT of the sigmoid colon: a case report. 61
31768246 2019
7
A challenging diagnosis of mesenchymal neoplasm of the colon: colonic dedifferentiated liposarcoma with lymph node metastases-a case report and review of the literature. 61
31501928 2019
8
Gastrointestinal complications and extraintestinal manifestations of inflammatory bowel disease in Taiwan: A population-based study. 61
27838292 2017
9
Impact of procedure on the post-operative infection risk of patients after elective colon surgery. 61
25401415 2014
10
[Turcot syndrome. Rare observation and literature review]. 61
23866578 2013
11
[Adenocarcinoid neoplasm of the colon. Case report]. 61
23234749 2012
12
[Complications of distal intestinal occlusion treatment with endoluminal implants]. 61
21640986 2011
13
Incidence of colorectal cancer in Poland in 1999-2008. 61
22291804 2011
14
Primary sclerosing cholangitis and extraintestinal manifestations in patients with ulcerative colitis and ileal pouch-anal anastomosis. 61
20480253 2010
15
Perivascular epithelioid cell neoplasm of the colon. 61
21160599 2010
16
A palpable, obstructing carcinoma of the colon incarcerated within a large ventral hernia. 61
16843881 2006
17
[Proctological diseases in routine urologic practice]. 61
14579848 2003
18
Patients with multiple myeloma and solid tumors: six case reports. 61
9700587 1998
19
[Colonic tumors: experience at a clinical center in Caracas]. 61
7926615 1994
20
[Laparoscopic-assisted colectomy]. 61
8144081 1994
21
[Neoplasm of the colon and Barrett esophagus]. 61
2813916 1989
22
Psoas abscess demonstrated by CT as the first evidence of carcinoma of the colon. 61
3436132 1987
23
[Carcinoma of the endometrium, neoplasm of the colon and adenocarcinoma of the rectum in the same patient]. 61
3738055 1986
24
[Neoplasm of the colon. Clinical and therapeutic considerations on 80 cases]. 61
6062635 1967
25
[Pseudo-neoplasm of the colon of amebic etiology]. 61
14956115 1952
26
TESTS OF HEPATIC FUNCTION IN CARCINOMA; THEIR VALUE IN CASES OF NEOPLASM OF THE COLON WITH AND WITHOUT METASTASIS TO THE LIVER. 61
17866259 1930

Variations for Colonic Benign Neoplasm

ClinVar genetic disease variations for Colonic Benign Neoplasm:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 BRAF NM_004333.6(BRAF):c.1799_1800delinsAA (p.Val600Glu) Indel Likely pathogenic 376069 rs121913377 GRCh37: 7:140453135-140453136
GRCh38: 7:140753335-140753336
2 ERBB3 NM_001982.3(ERBB3):c.850G>A (p.Gly284Arg) SNV Likely pathogenic 376167 rs1057519803 GRCh37: 12:56481922-56481922
GRCh38: 12:56088138-56088138
3 BRAF NM_001374258.1(BRAF):c.1919T>A (p.Val640Glu) SNV Likely pathogenic 13961 rs113488022 GRCh37: 7:140453136-140453136
GRCh38: 7:140753336-140753336
4 TP53 NM_000546.5(TP53):c.1060C>A (p.Gln354Lys) SNV Uncertain significance 231485 rs755394212 GRCh37: 17:7573967-7573967
GRCh38: 17:7670649-7670649

Expression for Colonic Benign Neoplasm

Search GEO for disease gene expression data for Colonic Benign Neoplasm.

Pathways for Colonic Benign Neoplasm

Pathways related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 TP53 PTGS2 KRAS HRAS ERBB3 CTNNB1
2
Show member pathways
12.92 TP53 PTGS2 KRAS HRAS ERBB3 CTNNB1
3
Show member pathways
12.79 TP53 MLH1 KRAS HRAS CTNNB1 BRAF
4 12.75 TP53 KRAS HRAS ERBB3 BRAF
5 12.73 TP53 PTGS2 MLH1 KRAS HRAS CTNNB1
6
Show member pathways
12.66 TP53 KRAS HRAS ERBB3 BRAF
7
Show member pathways
12.59 TP53 KRAS HRAS ERBB3 BRAF
8
Show member pathways
12.59 TP53 MLH1 KRAS HRAS CTNNB1 CDX2
9
Show member pathways
12.49 TP53 PTGS2 KRAS HRAS ERBB3 CTNNB1
10
Show member pathways
12.39 TP53 KRAS HRAS ERBB3 CTNNB1
11
Show member pathways
12.38 TP53 LGR5 KRAS HRAS ERBB3 BRAF
12
Show member pathways
12.33 KRAS HRAS ERBB3 CTNNB1 BRAF APC
13
Show member pathways
12.33 PTGS2 KRAS HRAS CTNNB1 BRAF
14
Show member pathways
12.29 TP53 HRAS CTNNB1 APC
15
Show member pathways
12.28 TP53 KRAS HRAS BRAF
16
Show member pathways
12.28 KRAS HRAS ERBB3 CTNNB1 BRAF
17 12.22 TP53 KRAS HRAS ERBB3 CTNNB1 BRAF
18
Show member pathways
12.19 TP53 KRAS HRAS ERBB3 BRAF
19 12.17 TP53 LGR5 CTNNB1 APC
20
Show member pathways
12.15 TP53 KRAS HRAS BRAF
21 12.12 TP53 KRAS CTNNB1 BRAF
22
Show member pathways
12.11 TP53 KRAS HRAS BRAF
23 12.07 KRAS HRAS CTNNB1 APC
24 11.98 KRAS HRAS CTNNB1 APC
25 11.97 TP53 KRAS HRAS CTNNB1
26 11.94 PTGS2 KRAS HRAS BRAF
27 11.94 TP53 KRAS HRAS CTNNB1 APC
28 11.81 TP53 PTGS2 MIR20A MIR18A MIR15A MIR143
29
Show member pathways
11.79 KRAS HRAS BRAF
30 11.76 TP53 KRAS BRAF
31 11.72 KRAS HRAS BRAF
32 11.72 TP53 PTGS2 MLH1 KRAS CTNNB1 BRAF
33 11.7 TP53 KRAS HRAS
34 11.69 TP53 KRAS HRAS BRAF
35 11.68 TP53 KRAS HRAS
36 11.68 TP53 KRAS HRAS CTNNB1 BRAF APC
37
Show member pathways
11.66 KRAS HRAS BRAF
38 11.62 KRAS HRAS BRAF
39 11.59 KRAS HRAS ERBB3
40 11.5 PTGS2 KRAS HRAS
41 11.43 KRAS HRAS BRAF
42 11.36 KRAS HRAS BRAF
43 11.29 KRAS HRAS BRAF
44 11.23 KRAS HRAS CTNNB1 APC

GO Terms for Colonic Benign Neoplasm

Cellular components related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lateral plasma membrane GO:0016328 8.8 ERBB3 CTNNB1 APC

Biological processes related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.8 TP53 PTGS2 MIR15A CTNNB1 APC
2 negative regulation of cell proliferation GO:0008285 9.73 TP53 PTGS2 MIR15A HRAS CTNNB1 APC
3 positive regulation of cell proliferation GO:0008284 9.7 PTGS2 KRAS KDM4C HRAS ERBB3 CTNNB1
4 Ras protein signal transduction GO:0007265 9.63 TP53 KRAS HRAS
5 negative regulation of neuron apoptotic process GO:0043524 9.62 KRAS HRAS ERBB3 BRAF
6 positive regulation of gene expression GO:0010628 9.5 TP53 KRAS KDM4C HRAS ERBB3 CTNNB1
7 response to isolation stress GO:0035900 9.43 KRAS HRAS
8 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.37 MIR20A MIR143
9 regulation of cell proliferation GO:0042127 9.1 TP53 PTGS2 LGR5 ERBB3 CTNNB1 BRAF

Molecular functions related to Colonic Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.35 TP53 PTGS2 MLH1 KDM4C CTNNB1
2 mRNA 3'-UTR binding GO:0003730 8.92 TP53 MIR20A MIR15A MIR143

Sources for Colonic Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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