MCID: CLN019
MIFTS: 57

Colonic Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Colonic Disease

MalaCards integrated aliases for Colonic Disease:

Name: Colonic Disease 12 15
Colonic Diseases 55 43 44 73
Colon Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5353
MeSH 44 D003108
UMLS 73 C0009373

Summaries for Colonic Disease

MedlinePlus : 43 Your colon, also known as the large intestine, is part of your digestive system. It's a long, hollow tube at the end of your digestive tract where your body makes and stores stool. Many disorders affect the colon's ability to work properly. Some of these include Colorectal cancer Colonic polyps - extra tissue growing in the colon that can become cancerous Ulcerative colitis - ulcers of the colon and rectum Diverticulitis - inflammation or infection of pouches in the colon Irritable bowel syndrome - an uncomfortable condition causing abdominal cramping and other symptoms Treatment for colonic diseases varies greatly depending on the disease and its severity. Treatment may involve diet, medicines and in some cases, surgery. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Colonic Disease, also known as colonic diseases, is related to megacolon and ulcerative colitis, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Colonic Disease is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Bisacodyl and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and kidney, and related phenotypes are digestive/alimentary and cellular

Wikipedia : 76 The large intestine, also known as the large bowel or colon, is the last part of the gastrointestinal... more...

Related Diseases for Colonic Disease

Diseases related to Colonic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
# Related Disease Score Top Affiliating Genes
1 megacolon 31.6 EDN3 EDNRB RET SOX10
2 ulcerative colitis 30.0 CTNNB1 MLH1 MSH2 NOD2
3 colitis 30.0 CTNNB1 MLH1 NOD2 PTGS2 TLR9
4 familial adenomatous polyposis 29.5 CTNNB1 KRAS MLH1 MSH2 PTGS2 TP53
5 pancreatic cancer 29.3 AREG CASP3 CEACAM5 CTNNB1 HRAS KRAS
6 functional colonic disease 12.1
7 diverticulitis of colon 10.8
8 endometrial clear cell adenocarcinoma 10.4 CTSD ESR1
9 gastric adenosquamous carcinoma 10.4 DDX53 STAT3 TP53
10 female reproductive endometrioid cancer 10.4 CTNNB1 ESR1 TP53
11 adult hepatocellular carcinoma 10.3 CTNNB1 TP53
12 tongue disease 10.3 CTNNB1 TLR9 TP53
13 sebaceous adenoma 10.3 ESR1 MLH1 MSH2
14 nasal cavity adenocarcinoma 10.3 HRAS KRAS TP53
15 appendix carcinoid tumor 10.3 MLH1 MSH2
16 adenosquamous gallbladder carcinoma 10.3 CEACAM5 CTSD
17 biliary tract neoplasm 10.3 HRAS KRAS TP53
18 rare adenocarcinoma of the breast 10.3 KRAS TP53
19 liver angiosarcoma 10.3 HRAS KRAS TP53
20 waardenburg syndrome type 4 10.3 EDN3 EDNRB SOX10
21 colorectal cancer, hereditary nonpolyposis, type 7 10.3 MLH1 MSH2
22 ampulla of vater cancer 10.3 HRAS KRAS TP53
23 sigmoid neoplasm 10.3 CEACAM5 HRAS KRAS
24 adenosquamous lung carcinoma 10.3 HRAS KRAS RET
25 cervical adenocarcinoma 10.3 ESR1 PTGS2 TP53
26 barrett's adenocarcinoma 10.3 KRAS PTGS2 TP53
27 intracranial chondrosarcoma 10.3 CEACAM5 TP53
28 waardenburg syndrome, type 4b 10.3 EDN3 EDNRB SOX10
29 apocrine adenoma 10.3 CEACAM5 HRAS KRAS
30 cochlear disease 10.3 EDN3 EDNRB SOX10
31 breast ductal carcinoma 10.3 CTNNB1 CTSD ESR1 TP53
32 goldberg-shprintzen syndrome 10.3 EDN3 EDNRB RET
33 ductal carcinoma in situ 10.3 ESR1 PTGS2 TP53
34 lung benign neoplasm 10.3 HRAS KRAS TP53
35 aggressive digital papillary adenocarcinoma 10.3 CEACAM5 HRAS KRAS
36 supratentorial cancer 10.3 CASP3 STAT3 TP53
37 cerebrum cancer 10.3 CASP3 STAT3 TP53
38 prostate squamous cell carcinoma 10.3 CEACAM5 HRAS TP53
39 nasopharyngeal disease 10.3 CASP3 CTNNB1 TP53
40 lower lip cancer 10.3 CASP3 MLH1 MSH2
41 melanocytic nevus syndrome, congenital 10.3 HRAS MLH1 MSH2
42 lymphadenitis 10.3 CASP3 NOD2 STAT3
43 adenosquamous colon carcinoma 10.3 MLH1 MSH2
44 peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease 10.3 EDN3 EDNRB SOX10
45 ureteral obstruction 10.3 CTNNB1 PTGS2 TP53
46 intestinal pseudo-obstruction 10.3 EDNRB RET SOX10
47 keratoacanthoma 10.3 MLH1 MSH2 TP53
48 pharynx cancer 10.3 CASP3 CTNNB1 TP53
49 mixed cell type cancer 10.3 CEACAM5 HRAS TP53
50 waardenburg syndrome, type 2a 10.3 EDN3 EDNRB SOX10

Graphical network of the top 20 diseases related to Colonic Disease:



Diseases related to Colonic Disease

Symptoms & Phenotypes for Colonic Disease

UMLS symptoms related to Colonic Disease:


nausea and vomiting, constipation, abdominal pain, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas

MGI Mouse Phenotypes related to Colonic Disease:

46 (show all 26)
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.56 AREG CASP3 CTNNB1 CTSD EDN3 EDNRB
2 cellular MP:0005384 10.49 CASP3 CTNNB1 CTSD EDNRB ESR1 KRAS
3 homeostasis/metabolism MP:0005376 10.49 AREG CASP3 CTNNB1 CTSD EDNRB ESR1
4 mortality/aging MP:0010768 10.46 AREG CASP3 CTNNB1 CTSD EDN3 EDNRB
5 behavior/neurological MP:0005386 10.44 CASP3 CTNNB1 CTSD EDN3 EDNRB ESR1
6 endocrine/exocrine gland MP:0005379 10.44 AREG CASP3 CTNNB1 CTSD EDNRB ESR1
7 hematopoietic system MP:0005397 10.44 AREG CASP3 CTNNB1 CTSD EDNRB ESR1
8 growth/size/body region MP:0005378 10.43 AREG CASP3 CTNNB1 CTSD EDNRB ESR1
9 immune system MP:0005387 10.42 AREG CASP3 CTNNB1 CTSD EDNRB ESR1
10 integument MP:0010771 10.41 AREG CASP3 CTNNB1 CTSD EDN3 EDNRB
11 cardiovascular system MP:0005385 10.36 AREG CASP3 CTNNB1 EDNRB ESR1 HRAS
12 embryo MP:0005380 10.3 CTNNB1 EDN3 EDNRB ESR1 KRAS PTGS2
13 nervous system MP:0003631 10.3 CASP3 CTNNB1 CTSD EDN3 EDNRB ESR1
14 neoplasm MP:0002006 10.26 CTNNB1 EDNRB ESR1 HRAS KRAS MLH1
15 craniofacial MP:0005382 10.16 CASP3 CTNNB1 EDNRB HRAS KRAS STAT3
16 muscle MP:0005369 10.15 CASP3 CTNNB1 EDNRB ESR1 KRAS PTGS2
17 no phenotypic analysis MP:0003012 10.09 CASP3 CTNNB1 ESR1 HRAS KRAS PTGS2
18 limbs/digits/tail MP:0005371 10.07 CTNNB1 EDNRB ESR1 KRAS RET SOX10
19 normal MP:0002873 10.06 CTNNB1 ESR1 HRAS KRAS PTGS2 RET
20 renal/urinary system MP:0005367 10.06 CASP3 CTNNB1 EDNRB ESR1 HRAS KRAS
21 hearing/vestibular/ear MP:0005377 10.05 CASP3 CTNNB1 CTSD EDNRB KRAS TP53
22 reproductive system MP:0005389 9.96 AREG CASP3 CTNNB1 ESR1 KRAS MLH1
23 respiratory system MP:0005388 9.93 CASP3 CTNNB1 EDNRB ESR1 HRAS KRAS
24 pigmentation MP:0001186 9.91 CASP3 CTNNB1 EDN3 EDNRB KRAS SOX10
25 skeleton MP:0005390 9.65 CASP3 CTNNB1 EDNRB ESR1 HRAS KRAS
26 vision/eye MP:0005391 9.32 AREG CASP3 CTNNB1 CTSD EDNRB KRAS

Drugs & Therapeutics for Colonic Disease

Drugs for Colonic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 960)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bisacodyl Approved Phase 4,Not Applicable 603-50-9
2
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-78-2 2244
3
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 170277-31-3
4
Pentoxifylline Approved, Investigational Phase 4,Phase 2 6493-05-6 4740
5
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
6 tannic acid Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
7
Azathioprine Approved Phase 4,Phase 3,Not Applicable 446-86-6 2265
8
Iron Approved Phase 4,Phase 3,Phase 2,Not Applicable 7439-89-6 23925
9
Tegafur Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 17902-23-7 5386
10
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 154361-50-9 60953
11
Epirubicin Approved Phase 4,Phase 2 56420-45-2 41867
12
Ethiodized oil Approved, Investigational Phase 4,Phase 2 8008-53-5
13
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 61825-94-3 43805 6857599 5310940 9887054
14
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
15
Raltitrexed Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 112887-68-0 104758
16
Erythromycin Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 114-07-8 12560
17
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 51-21-8 3385
18
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 216974-75-3
19
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 100286-90-6, 97682-44-5 60838
20
Levoleucovorin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 68538-85-2
21
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
22
Cetuximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 205923-56-4 56842117 2333
23
Phytonadione Approved, Investigational Phase 4,Phase 2 84-80-0 4812 5284607
24
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
25
Iodine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 7553-56-2 807
26
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
27
Pancrelipase Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 53608-75-6
28
Loperamide Approved Phase 4,Phase 2,Phase 3,Not Applicable 53179-11-6 3955
29
Curcumin Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 458-37-7 969516
30
Turmeric Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
31
Tocopherol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1406-66-2 14986
32
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
33
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6 772 46507594
34
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 169590-42-5 2662
35
Rifaximin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 80621-81-4 6436173
36
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 331731-18-1 16219006
37
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 50-24-8 5755
38
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 302-25-0
39
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 2921-57-5
40
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 83-43-2 6741
41
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 50-03-3
42
Hydrocortisone Approved, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 50-23-7 5754
43 Vedolizumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 943609-66-3
44
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
45
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1177-87-3
46
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 564-25-0 54671203
47
Aminosalicylic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 65-49-6 4649
48
Midazolam Approved, Illicit Phase 4,Phase 1,Not Applicable 59467-70-8 4192
49
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable,Early Phase 1 437-38-7 3345
50
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 2078-54-8 4943

Interventional clinical trials:

(show top 50) (show all 5417)
# Name Status NCT ID Phase Drugs
1 Multidisciplinary Approach Versus Conventional Approach in Colonic Preparation of Hospitalized Patients Unknown status NCT01853709 Phase 4 Polyethylene glycol (PEG);Bisacodyl
2 The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Taking Aspirin Unknown status NCT01549418 Phase 4 Aspirin (ASA);Placebo
3 Safety and Therapeutic Efficacy of Phosphate Enema (Kleen Enema) in Patients Undergoing Sigmoidoscopy Unknown status NCT02386904 Phase 4 Phosphate Enema (Kleen® Enema)
4 The Efficacy of Hydrolyzed Guar Gum ( PHGG) in the Treatment of Patients With Irritable Bowel Syndrome (IBS) Unknown status NCT01779765 Phase 4
5 Changes in Gastrointestinal Microbiota Using VSL#3 in Patients With IBS-D Unknown status NCT01638208 Phase 4 VSL#3
6 "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" Unknown status NCT02452151 Phase 4 Infliximab-Biosimilar;Infliximab-Innovator
7 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation Unknown status NCT01078935 Phase 4
8 Effect of Clostridium Butyricum in Treating Irritable Bowel Syndrome Unknown status NCT02614963 Phase 4 Clostridium Butyricum;placebo
9 Pain Relief In Irritable Bowel Syndrome Unknown status NCT02573844 Phase 4 Proklama
10 Is Microbiota Community Associated With Clinical Response to a Low FODMAP Diet in Patients With Irritable Bowel Syndrome Unknown status NCT02565550 Phase 4
11 Comparison of the Efficacy and Safety of Tiropramide and Octylonium in the Treatment of Irritable Bowel Syndrome Unknown status NCT01629212 Phase 4 Tiropramide HCl 100mg;Octylonium bromide 20mg
12 Effect of Pentoxifylline on Tight Junctions (TJs) of Intestinal Mucosa in Patients With Irritable Bowel Syndrome(IBS) Unknown status NCT01542268 Phase 4 pentoxifylline;pentoxifylline placebo
13 Lactibiane Tolérance® in Individuals Suffering From Irritable Bowel Syndrome With Diarrheal Predominance Unknown status NCT02728063 Phase 4
14 Effect of Mosapride on Gut Transit in Patients With Chronic Constipation or Constipated Irritable Bowel Syndrome and Healthy Subjects Unknown status NCT02433847 Phase 4 Mosapride
15 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
16 Saccharomyces Boulardii in Diarrhea Dominant Irritable Bowel Syndrome Unknown status NCT00543478 Phase 4 Saccharomyces boulardii;Methyl cellulose powder (low viscosity)
17 Fecal Microbiota Transplantation for Ulcerative Colitis Through Colonic Transendoscopic Enteral Tubing Unknown status NCT02998112 Phase 4 fecal microbiota transplantation;Saline
18 Efficacy of Treatment With Berberine to Maintain Remission in Ulcerative Colitis Unknown status NCT02962245 Phase 4 berberine;regular treatment
19 Azathioprine Based on Endoscopy After Clinical Remission in Moderate to Severe Ulcerative Colitis Unknown status NCT02579733 Phase 4 Azathioprine;Placebo
20 Golimumab in Steroid-dependent Ulcerative Colitis: Induction and Maintenance of Clinical and Endoscopic Remission Unknown status NCT02412085 Phase 4 Golimumab
21 Physiological Intermolecular Modification Spectroscopy (PIMS) in Ulcerative Colitis With Golimumab Unknown status NCT02186886 Phase 4 Golimumab
22 Clostridial Infection and Oral Lavage -Improving Treatment Before Illness Becomes Severe Unknown status NCT01630096 Phase 4 Nu-Lytely
23 Role of Healthy Bacteria in Ulcerative Colitis Unknown status NCT01479660 Phase 4 Probiotic
24 Intravenous Iron for Correction of Anaemia After Colorectal Surgery Unknown status NCT02999217 Phase 4 Iron isomaltoside;Saline
25 A Phase II Study of Tegafur-Uracil as Maintenance Chemotherapy in Patients With Stage II of Colon Cancer Unknown status NCT02887365 Phase 4 tegafur-uracil
26 Maintenance Treatment With Capecitabine Metronomic Chemotherapy and Chinese Traditional Medicine in Metastatic Colorectal Cancer Unknown status NCT02575378 Phase 4 Metronimic chemotherapy plus Chinese Traditional Medicine;Metronimic chemotherapy
27 Oxaliplatin and Raltitrexed Treatment of Colorectal Cancer With Liver Metastases Unknown status NCT02557490 Phase 4 oxaliplatin and raltitrexed
28 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-minors' Adjusted Version Unknown status NCT02354560 Phase 4 Erythromycin
29 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis Unknown status NCT02175914 Phase 4 Erythromycin
30 Intraoperative Intraportal Chemotherapy Combined With Adjuvant Chemotherapy for Stage II and III Colorectal Cancer Unknown status NCT01972503 Phase 4 5-FU and oxaliplatin
31 Avastin in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01972490 Phase 4 avastin+chemotherapy of mFOLFOX6 or FOLFIRI;chemotherapy of mFOLFOX6 or FOLFIRI
32 NK Activity Modulation Induced by Intravenous Lidocaine During Colorectal Laparoscopic Surgery Unknown status NCT01841294 Phase 4 Intravenous Lidocaine;Normal saline infusion
33 Participation and Detection Rate Diagnostic of a Colorectal Cancer Screening Program: CT Colonography vs. Flexible Sigmoidoscopy Unknown status NCT01739608 Phase 4
34 Efficacy and Patient Satisfaction of Miralax and Gatorade Versus Movi Prep Unknown status NCT01695863 Phase 4 comparing 2 drugs on their effect on the bowel preparation for colonoscopy
35 Cetuximab in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01564810 Phase 4 Cetuximab;chemotherapy of mFOLFOX6 or FOLFIRI
36 FOLFIRI in Combination With Cetuximab in the First-line Treatment of Metastatic Colorectal Cancer Including a Regular Dermal Prophylaxis to Prevent Acneiforme Follicular Exanthema Unknown status NCT01315990 Phase 4 FOLFIRI + Cetuximab
37 New Adjuvant Chemotherapy of Non Resectable Liver Metastasis of Colorectal Cancer Without Bleeding, Obstruction Unknown status NCT01307878 Phase 4 chemotherapy ± targeted therapy
38 OPTIMOX1 in Chinese mCRC Patients Unknown status NCT01023633 Phase 4 Oxaliplatin, LV, 5-FU
39 Preoperative Transhepatic Arterial Chemotherapy (TAC) in the Treatment of Liver Metastasis of Resectable Colorectal Cancer Unknown status NCT00874406 Phase 4 tac + folfox4;folfox4
40 Transhepatic Arterial Chemotherapy (TAC) Versus Transcatheter Arterial Chemoembolization (TACE) Plus Folfox4 as the Treatment of Unresectable Liver Metastasis of Colorectal Cancer Unknown status NCT00868569 Phase 4
41 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
42 Preoperative Assessment of Colon Tumor Unknown status NCT00114829 Phase 4
43 Study to Evaluate the Duration of Treatment With Ertapenem in Acute Attacks of Sigmoid Diverticulitis Unknown status NCT00097734 Phase 4 ertapenem
44 Endoscopic Detection of Dysplasia in Crohn 's Disease Patient Completed NCT01180452 Phase 4
45 Comparison of Post Anesthetic Recovery Time in Sedated Patients for Colonoscopy Completed NCT03813303 Phase 4 Midazolam;Fentanyl;Propofol
46 A Study to Evaluate Efficacy of Ramosetron on Diarrhea-predominant Irritable Bowel Syndrome (IBS) in Male Patients Completed NCT01225237 Phase 4 Ramosetron;Placebo
47 A Preliminary Study to Explore Clinical Endpoints in Patients (Male) With Diarrhea-predominant Irritable Bowel Syndrome Completed NCT00918411 Phase 4 Ramosetron;Placebo
48 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Completed NCT02010762 Phase 4 Vitamin D;Placebo
49 Effect of Cholecalciferol, Soy Isoflavones in Patients With Irritable Bowel Syndrome Completed NCT02026518 Phase 4
50 Study to Assess the Effect Of Alosetron On Mucosal Blood Flow Completed NCT00370032 Phase 4 alosetron

Search NIH Clinical Center for Colonic Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: colonic diseases

Genetic Tests for Colonic Disease

Anatomical Context for Colonic Disease

MalaCards organs/tissues related to Colonic Disease:

41
Colon, Testes, Kidney, Liver, Lung, Bone, Thyroid

Publications for Colonic Disease

Articles related to Colonic Disease:

(show top 50) (show all 119)
# Title Authors Year
1
Pancreatic cancer presenting as colonic disease. A rare case report. ( 29454229 )
2018
2
Reliability of Measuring Ileo-Colonic Disease Activity in Crohn's Disease by Magnetic Resonance Enterography. ( 29361096 )
2018
3
The Growing Utilization of Laparoscopy in Emergent Colonic Disease. ( 29391097 )
2017
4
Melatonin's role as a co-adjuvant treatment in colonic diseases: A review. ( 27919824 )
2017
5
Therapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseases. ( 27672289 )
2016
6
Advances in colonic disease: some light at the end of the tunnel at the end of the light! ( 26628103 )
2016
7
Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway. ( 26937622 )
2016
8
Colonic disease site and perioperative complications predict need for later intestinal interventions following intestinal resection in pediatric Crohn's disease. ( 26653943 )
2016
9
Single-incision versus standard multi-incision laparoscopic colectomy in patients with malignant or benign colonic disease: a systematic review, meta-analysis and assessment of the evidence. ( 27756272 )
2016
10
Emerging Roles of Hydrogen Sulfide in Inflammatory and Neoplastic Colonic Diseases. ( 27199771 )
2016
11
Raman Spectroscopy for the Endoscopic Diagnosis of Esophageal, Gastric, and Colonic Diseases. ( 27653440 )
2016
12
PillCam colon capsule endoscopy (PCCE) in colonic diseases. ( 27668227 )
2016
13
Erratum to PillCam colon capsule endoscopy (PCCE) in colonic diseases. ( 27761464 )
2016
14
Concomitant colonic disease (Montreal L3) and re-resectional surgery are predictors of clinical recurrence following ileocolonic resection for Crohn's disease. ( 26291699 )
2015
15
Robotic versus laparoscopic surgery for colonic disease: a meta-analysis of postoperative variables. ( 25847139 )
2015
16
Feasibility of real-time strain elastography in colonic diseases. ( 25368693 )
2014
17
Curcumin: a boon to colonic diseases. ( 23768171 )
2013
18
Enteric infection with Citrobacter rodentium induces coagulative liver necrosis and hepatic inflammation prior to peak infection and colonic disease. ( 22427959 )
2012
19
Is proliferative colonic disease presentation changing? ( 23236236 )
2012
20
The colonic microbiota and colonic disease. ( 22941733 )
2012
21
Novel prodrugs for the treatment of colonic diseases based on 5-aminosalicylic acid, 4'-geranyloxyferulic acid, and auraptene: biological activities and analytical assays. ( 22283649 )
2012
22
Colonic FDG uptake pattern in subjects receiving oral contrast with no known or suspected colonic disease. ( 21825842 )
2011
23
Design and in vitro evaluation of a bipolymeric delivery device for the amelioration of colonic diseases using a popular glucocorticoid as a model drug. ( 21928719 )
2011
24
Advanced diagnostic imaging in colonic disease. ( 20190723 )
2010
25
European Society of Gastrointestinal Endoscopy (ESGE): recommendations (2009) on clinical use of video capsule endoscopy to investigate small-bowel, esophageal and colonic diseases. ( 20195992 )
2010
26
Emergency laparoscopic surgery for right colonic diseases with peritonitis. ( 20687816 )
2010
27
Colonic perforation during barium enema in a patient without known colonic disease: a case report. ( 19918538 )
2009
28
Balsalazide in treating colonic diseases. ( 19708827 )
2009
29
Third ESPGHAN Capri Meeting, "Colonic Diseases: Problems and Progress", in Capri, Italy, April 2-4, 2009. Introduction. ( 19300121 )
2009
30
Biochemical and immunohistochemical characterisation of mucins in 8 cases of colonic disease--a pilot study. ( 17969773 )
2007
31
Acute colonic disease: how to image in emergency. ( 17174054 )
2007
32
Colonic diseases: the value of US examination. ( 17889476 )
2007
33
Death from colonic disease in epidermolysis bullosa dystrophica. ( 16480504 )
2006
34
Colonic perforation at CT colonography in a patient without known colonic disease. ( 16357389 )
2006
35
Coprocytobiology: on the nature of cellular elements from stools in the pathophysiology of colonic disease. ( 12702972 )
2003
36
Cerebrospinal fluid polyamine levels in patients with colonic disease. ( 12567356 )
2003
37
Halo sign: useful CT sign for differentiating benign from malignant colonic disease. ( 12662952 )
2003
38
Prebiotics: actual and potential effects in inflammatory and malignant colonic diseases. ( 12913677 )
2003
39
Interleukin-2-Deficient mice: effect on cytokines and inflammatory cells in chronic colonic disease. ( 11913411 )
2002
40
The course of colonic disease in ulcerative colitis patients with primary sclerosing cholangitis. ( 16378294 )
2002
41
Development of a chronic colonic intubation model in rats for the study of luminal factors in colonic diseases. ( 11852341 )
2002
42
Variability in the severity of colonic disease in familial adenomatous polyposis results from differences in tumour initiation rather than progression and depends relatively little on patient age. ( 11559652 )
2001
43
Apoptotic colonic disease: a new entity in a primate. ( 11286126 )
2001
44
Investigation of colonic disease. ( 11103279 )
2000
45
Aberrant crypt foci in patients with neoplastic and nonneoplastic colonic disease. ( 9923929 )
1999
46
Psoas abscesses complicating colonic disease: imaging and therapy. ( 10645182 )
1999
47
Cystic fibrosis: CT findings of colonic disease. ( 9494492 )
1998
48
Diagnosis and treatment of colonic disease in AIDS. ( 9730938 )
1998
49
Colonic disease in cirrhotic patients with portal hypertension: an endoscopic and clinical evaluation. ( 9600375 )
1998
50
Psoas abscesses complicating colonic disease: imaging and therapy. ( 10209409 )
1998

Variations for Colonic Disease

Expression for Colonic Disease

Search GEO for disease gene expression data for Colonic Disease.

Pathways for Colonic Disease

Pathways related to Colonic Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.07 CASP3 CTNNB1 CTSD HRAS KRAS NOD2
2
Show member pathways
13.89 AREG CASP3 CTNNB1 ESR1 HRAS KRAS
3
Show member pathways
13.38 CASP3 HRAS KRAS NOD2 PTGS2 RET
4
Show member pathways
13.06 CASP3 CTNNB1 HRAS KRAS PTGS2 STAT3
5
Show member pathways
13.05 CASP3 CTNNB1 HRAS KRAS STAT3 TP53
6
Show member pathways
12.98 AREG CASP3 CTNNB1 HRAS KRAS PTGS2
7
Show member pathways
12.96 CASP3 EDN3 EDNRB HRAS KRAS TP53
8
Show member pathways
12.9 HRAS KRAS MLH1 MSH2 PTGS2 STAT3
9
Show member pathways
12.83 CASP3 CTSD HRAS KRAS TP53
10
Show member pathways
12.8 ESR1 HRAS KRAS STAT3 TP53
11 12.79 AREG CASP3 HRAS KRAS TP53
12
Show member pathways
12.77 CTNNB1 ESR1 HRAS KRAS MLH1 TP53
13
Show member pathways
12.72 CASP3 HRAS KRAS STAT3 TP53
14
Show member pathways
12.6 CASP3 CTNNB1 ESR1 HRAS KRAS PTGS2
15
Show member pathways
12.6 AREG CASP3 CTNNB1 HRAS KRAS MLH1
16
Show member pathways
12.55 CTNNB1 HRAS KRAS MSH2 STAT3 TP53
17
Show member pathways
12.51 AREG HRAS KRAS STAT3 TP53
18 12.48 CASP3 HRAS KRAS PTGS2 STAT3 TP53
19
Show member pathways
12.46 CASP3 CTNNB1 HRAS KRAS TP53
20
Show member pathways
12.46 AREG CASP3 CTNNB1 HRAS KRAS STAT3
21
Show member pathways
12.44 CTNNB1 EDNRB HRAS KRAS
22 12.44 CTNNB1 HRAS KRAS TP53
23
Show member pathways
12.43 AREG CTNNB1 HRAS KRAS STAT3
24
Show member pathways
12.42 CASP3 CTSD ESR1 HRAS KRAS STAT3
25
Show member pathways
12.32 CTNNB1 ESR1 HRAS KRAS PTGS2 STAT3
26 12.29 CASP3 HRAS KRAS STAT3 TP53
27 12.26 CASP3 CTSD NOD2 TLR9
28
Show member pathways
12.26 CASP3 HRAS KRAS STAT3 TP53
29
Show member pathways
12.24 HRAS KRAS PTGS2 TLR9
30
Show member pathways
12.23 CASP3 HRAS KRAS TP53
31
Show member pathways
12.18 CASP3 HRAS KRAS TP53
32 12.17 CASP3 HRAS KRAS TP53
33 12.15 CASP3 CTNNB1 HRAS STAT3
34 12.13 CTNNB1 HRAS KRAS STAT3
35 12.12 CASP3 CTNNB1 EDNRB ESR1 HRAS KRAS
36 12.1 CTSD MLH1 MSH2 TP53
37 12.1 CASP3 CTNNB1 ESR1 HRAS KRAS STAT3
38
Show member pathways
12.09 CASP3 HRAS KRAS TP53
39 12.09 HRAS KRAS STAT3 TP53
40 12.07 CASP3 CTNNB1 ESR1 KRAS MSH2 TP53
41
Show member pathways
12.06 CASP3 CTSD HRAS KRAS
42 12.03 CTSD HRAS KRAS TP53
43 12.02 CTNNB1 HRAS KRAS TP53
44 12.01 CASP3 HRAS KRAS PTGS2
45 11.99 CTNNB1 HRAS KRAS TP53
46 11.94 CTNNB1 ESR1 HRAS KRAS TP53
47 11.92 CASP3 HRAS KRAS STAT3
48 11.89 CASP3 PTGS2 TP53
49
Show member pathways
11.87 HRAS KRAS STAT3
50 11.83 CASP3 CTNNB1 KRAS MLH1 MSH2 PTGS2

GO Terms for Colonic Disease

Cellular components related to Colonic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basolateral plasma membrane GO:0016323 9.26 CEACAM5 CTNNB1 NOD2 TLR9
2 membrane raft GO:0045121 9.02 CASP3 CTSD EDNRB KRAS RET

Biological processes related to Colonic Disease according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 regulation of apoptotic process GO:0042981 9.97 CTNNB1 ESR1 NOD2 TP53
2 response to drug GO:0042493 9.96 CASP3 CTNNB1 PTGS2 RET STAT3
3 cytokine-mediated signaling pathway GO:0019221 9.93 CASP3 KRAS PTGS2 STAT3 TP53
4 neuron differentiation GO:0030182 9.87 CASP3 CTNNB1 EDN3 RET
5 positive regulation of gene expression GO:0010628 9.86 CTNNB1 HRAS KRAS RET SOX10 STAT3
6 positive regulation of MAPK cascade GO:0043410 9.85 CTNNB1 HRAS RET TLR9
7 positive regulation of JNK cascade GO:0046330 9.83 HRAS NOD2 TLR9
8 cellular response to organic cyclic compound GO:0071407 9.81 CASP3 NOD2 STAT3
9 regulation of inflammatory response GO:0050727 9.81 ESR1 NOD2 PTGS2
10 negative regulation of apoptotic process GO:0043066 9.81 CASP3 CEACAM5 CTNNB1 EDNRB PTGS2 RET
11 Ras protein signal transduction GO:0007265 9.8 HRAS KRAS TP53
12 response to glucocorticoid GO:0051384 9.76 AREG CASP3 KRAS PTGS2
13 positive regulation of MAP kinase activity GO:0043406 9.73 EDN3 HRAS KRAS NOD2
14 response to organic cyclic compound GO:0014070 9.72 AREG CASP3 EDNRB PTGS2 STAT3
15 positive regulation of phospholipase C activity GO:0010863 9.67 ESR1 HRAS
16 neural crest cell migration GO:0001755 9.67 EDN3 EDNRB RET SOX10
17 protein localization to chromatin GO:0071168 9.66 ESR1 MSH2
18 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.65 ESR1 TP53
19 regulation of mitochondrial membrane permeability GO:0046902 9.65 STAT3 TP53
20 melanocyte differentiation GO:0030318 9.65 EDN3 EDNRB SOX10
21 positive regulation of isotype switching to IgG isotypes GO:0048304 9.64 MLH1 MSH2
22 response to isolation stress GO:0035900 9.62 HRAS KRAS
23 positive regulation of isotype switching to IgA isotypes GO:0048298 9.61 MLH1 MSH2
24 epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 9.59 AREG ESR1
25 somatic recombination of immunoglobulin gene segments GO:0016447 9.58 MLH1 MSH2
26 vein smooth muscle contraction GO:0014826 9.58 EDN3 EDNRB
27 enteric nervous system development GO:0048484 9.58 EDNRB RET SOX10
28 posterior midgut development GO:0007497 9.52 EDNRB RET
29 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.51 MLH1 MSH2
30 response to estradiol GO:0032355 9.43 AREG CASP3 CTNNB1 ESR1 PTGS2 STAT3
31 positive regulation of cell proliferation GO:0008284 9.28 AREG CTNNB1 EDN3 EDNRB HRAS KRAS
32 signal transduction GO:0007165 10.26 EDN3 EDNRB ESR1 HRAS KRAS RET
33 positive regulation of transcription by RNA polymerase II GO:0045944 10.1 CTNNB1 ESR1 HRAS NOD2 SOX10 STAT3
34 positive regulation of transcription, DNA-templated GO:0045893 10.08 CTNNB1 ESR1 RET SOX10 STAT3 TP53
35 negative regulation of cell proliferation GO:0008285 10.02 CTNNB1 HRAS PTGS2 STAT3 TP53
36 cell proliferation GO:0008283 10.01 AREG CTNNB1 HRAS STAT3 TP53

Molecular functions related to Colonic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.65 CTNNB1 ESR1 SOX10 STAT3 TP53
2 protein kinase binding GO:0019901 9.63 CTNNB1 ESR1 MSH2 NOD2 STAT3 TP53
3 protein phosphatase binding GO:0019903 9.54 CTNNB1 STAT3 TP53
4 chromatin binding GO:0003682 9.43 CTNNB1 ESR1 MLH1 MSH2 SOX10 TP53
5 mismatched DNA binding GO:0030983 9.4 MLH1 MSH2
6 guanine/thymine mispair binding GO:0032137 9.32 MLH1 MSH2
7 enzyme binding GO:0019899 9.17 CTNNB1 ESR1 MLH1 MSH2 NOD2 PTGS2

Sources for Colonic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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