MCID: CLN019
MIFTS: 47

Colonic Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Colonic Disease

MalaCards integrated aliases for Colonic Disease:

Name: Colonic Disease 12 15
Colonic Diseases 54 42 44 70
Colon Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5353
MeSH 44 D003108
SNOMED-CT 67 128524007
UMLS 70 C0009373

Summaries for Colonic Disease

MedlinePlus : 42 Your colon, also known as the large intestine, is part of your digestive system. It's a long, hollow tube at the end of your digestive tract where your body makes and stores stool. Many disorders affect the colon's ability to work properly. Some of these include Colorectal cancer Colonic polyps - extra tissue growing in the colon that can become cancerous Ulcerative colitis - ulcers of the colon and rectum Diverticulitis - inflammation or infection of pouches in the colon Irritable bowel syndrome - an uncomfortable condition causing abdominal cramping and other symptoms Treatment for colonic diseases varies greatly depending on the disease and its severity. Treatment may involve diet, medicines and in some cases, surgery. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Colonic Disease, also known as colonic diseases, is related to inflammatory bowel disease and colorectal adenoma, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Colonic Disease is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Prolactin Signaling Pathway and MicroRNAs in cancer. The drugs Sodium citrate and Sodium sulfate have been mentioned in the context of this disorder. Affiliated tissues include colon, thyroid and small intestine.

Disease Ontology : 12 A intestinal disease located in the colon.

Wikipedia : 73 The large intestine, also known as the large bowel, is the last part of the gastrointestinal tract and... more...

Related Diseases for Colonic Disease

Diseases related to Colonic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 282)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 30.6 STAT3 NOD2 MIR21 MIR155 CCR6 APC
2 colorectal adenoma 30.6 MIR21 MIR17 APC
3 cholangitis, primary sclerosing 30.4 NOD2 MIR199A1 CCR6
4 ileitis 30.4 STAT3 NOD2 CCR6
5 gastrointestinal system disease 30.4 MIR9-1 MIR31 MIR30A MIR21 MIR200A MIR199A1
6 intestinal disease 30.4 MIR9-1 MIR31 MIR30A MIR21 MIR200A MIR199A1
7 pancreatic cancer 30.3 STAT3 MIR31 MIR30A MIR21 MIR200A MIR199A1
8 colorectal cancer 30.3 STAT3 NOD2 MIR9-1 MIR31 MIR30A MIR21
9 functional colonic disease 11.2
10 megacolon 10.9
11 intestinal pseudo-obstruction 10.9
12 diverticulitis of colon 10.9
13 bacterial infectious disease 10.6 NOD2 MIR155 H2AC18 CCR6
14 mature t-cell and nk-cell lymphoma 10.6 STAT3 MIR199A1 MIR17 H2AC18 CCR6
15 autoimmune disease of gastrointestinal tract 10.6 STAT3 NOD2 MIR199A1 H2AC18 CCR6
16 breast implant-associated anaplastic large cell lymphoma 10.6 STAT3 JAK1 CCR6
17 pre-malignant neoplasm 10.6 MIR17 MIR143 H2AC18 ESR1 CCR6
18 esophagus adenocarcinoma 10.6 MIR21 MIR199A1 MIR145 MIR143
19 cervix small cell carcinoma 10.6 MIR199A1 MIR145 MIR143
20 colonic benign neoplasm 10.6 STAT3 MIR18A MIR143 H2AC18 CCR6 APC
21 lymphangioma 10.6 STAT3 MIR18A MIR143 H2AC18 CCR6 APC
22 cervix carcinoma 10.6 STAT3 MIR200A MIR199A1 H2AC18 ESR1 CCR6
23 vascular disease 10.6 MIR21 MIR199A1 MIR145 MIR143 MIR125A
24 retinal vascular disease 10.6 MIR30A MIR21 MIR199A1 MIR17 H2AC18
25 cerebral arterial disease 10.6 MIR199A1 MIR145 MIR143 MIR125A
26 pleural disease 10.6 MIR199A1 MIR17 MIR125A H2AC18 CCR6
27 in situ carcinoma 10.6 MIR17 MIR143 H2AC18 ESR1
28 gallbladder disease 10.6 MIR199A1 MIR17 MIR145 MIR143 CCR6
29 ovarian serous carcinoma 10.6 MIR21 MIR200A MIR199A1 MIR145 MIR143 MIR125A
30 immunodeficiency 35 10.6 STAT3 JAK1 CCR6
31 lymphadenitis 10.6 STAT3 NOD2 MIR145 CCR6
32 testicular disease 10.6 NOD2 MIR199A1 H2AC18 CCR6
33 tongue disease 10.6 STAT3 MIR31 MIR30A MIR21 MIR199A1 MIR18A
34 ovary adenocarcinoma 10.6 MIR30A MIR17 H2AC18 ESR1
35 extrinsic cardiomyopathy 10.6 MIR21 MIR199A1 H2AC18 CCR6
36 bone sarcoma 10.6 MIR9-1 MIR21 MIR199A1 MIR17 H2AC18
37 hypersensitivity reaction type iv disease 10.6 NOD2 MIR155 H2AC18 CCR6
38 intestinal benign neoplasm 10.6 STAT3 MIR21 MIR199A1 MIR18A MIR17 MIR145
39 uveal disease 10.6 NOD2 MIR9-1 MIR199A1 MIR125A H2AC18 CCR6
40 cardiovascular organ benign neoplasm 10.6 MIR143 H2AC18 CCR6 APC
41 bronchial disease 10.6 MIR21 MIR17 MIR155 H2AC18 CCR6
42 leukocyte disease 10.6 STAT3 MIR30A MIR21 MIR199A1 MIR17 MIR155
43 lipid storage disease 10.6 MIR21 MIR199A1 MIR155 H2AC18 CCR6
44 bone resorption disease 10.6 MIR199A1 H2AC18 ESR1 CCR6
45 autoimmune disease of musculoskeletal system 10.6 STAT3 MIR30A MIR21 MIR199A1 MIR17 MIR155
46 oropharynx cancer 10.6 MIR9-1 MIR199A1 H2AC18 APC
47 bone remodeling disease 10.6 MIR199A1 H2AC18 ESR1 CCR6
48 diffuse large b-cell lymphoma 10.6 STAT3 MIR21 MIR199A1 MIR17 MIR155 MIR145
49 thyroid gland disease 10.6 MIR9-1 MIR199A1 MIR17 MIR125A H2AC18 CCR6
50 infratentorial cancer 10.6 MIR9-1 MIR199A1 MIR18A MIR17 H2AC18 APC

Graphical network of the top 20 diseases related to Colonic Disease:



Diseases related to Colonic Disease

Symptoms & Phenotypes for Colonic Disease

UMLS symptoms related to Colonic Disease:


nausea and vomiting; constipation; abdominal pain; diarrhea; dyspepsia; icterus; heartburn; gastrointestinal gas

Drugs & Therapeutics for Colonic Disease

Drugs for Colonic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 87)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium citrate Approved, Investigational Phase 4 68-04-2
2
Sodium sulfate Approved, Vet_approved Phase 4 7757-82-6
3
Magnesium oxide Approved Phase 4 1309-48-4 14792
4
Magnesium citrate Approved Phase 4 3344-18-1
5
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
6
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
7 Cathartics Phase 4
8 Laxatives Phase 4
9 Citrate Phase 4
10 Polyethylene glycol 3350 Phase 4
11 Picosulfate sodium Phase 4
12
Dexmedetomidine Approved, Vet_approved Phase 3 113775-47-6 5311068 68602
13
Desipramine Approved, Investigational Phase 3 50-47-5 2995
14
Peppermint Approved Phase 3
15
Peppermint oil Approved, Investigational Phase 3 8006-90-4
16 Hypnotics and Sedatives Phase 3
17 Anesthetics, General Phase 3
18 Anesthetics, Intravenous Phase 3
19 Adrenergic alpha-Agonists Phase 3
20 Analgesics, Non-Narcotic Phase 3
21 Adrenergic Agonists Phase 3
22 Gastrointestinal Agents Phase 3
23 Pharmaceutical Solutions Phase 3
24 Neurotransmitter Agents Phase 3
25 Adrenergic Agents Phase 3
26 Antidepressive Agents Phase 3
27 Psychotropic Drugs Phase 3
28 Antidepressive Agents, Tricyclic Phase 3
29 Antiemetics Phase 3
30 Parasympatholytics Phase 3
31 insulin Phase 3
32 Insulin, Globin Zinc Phase 3
33
Fluorouracil Approved Phase 2 51-21-8 3385
34
leucovorin Approved Phase 2 58-05-9 6006
35
Menthol Approved Phase 2 2216-51-5 16666
36
Trimebutine Approved Phase 2 39133-31-8
37
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 43805 6857599
38
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
39
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4
40
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
41
Tyrosine Approved, Investigational, Nutraceutical Phase 1, Phase 2 60-18-4 6057
42 Vitamin B9 Phase 2
43 Antidotes Phase 2
44 Nutrients Phase 2
45 Trace Elements Phase 2
46 Micronutrients Phase 2
47 Protective Agents Phase 2
48 Vitamins Phase 2
49 Vitamin B Complex Phase 2
50 Folate Phase 2

Interventional clinical trials:

(show top 50) (show all 104)
# Name Status NCT ID Phase Drugs
1 A Randomized Clinical Trial Comparing Standard and Invidualized Bowel Preparation for Colonoscopy Unknown status NCT03428724 Phase 4 Standard Preparation;Individualized Preparation
2 Comparison of 1 Liter PEG With Ascorbate and Sodium Picosulfate / Magnesium Citrate for High Quality Colon Cleansing Recruiting NCT04598880 Phase 4 Polyethylene glycol + ascorbate;Sodium picosulfate + magnesium citrate
3 Colon Cleansing Efficacy With 1L PEG Versus 2L PEG and 4L PEG for Colonoscopy Among Inpatients: A Randomized Controlled Trial Not yet recruiting NCT04708366 Phase 4 NER1006;MoviPrep;Macrogol 400
4 Randomised Study Comparing the Use of Propofol Versus the Use of Dexmedetomidine as a Sedative Agent for Patients Presented for Lower Gastrointestinal Endoscopy Unknown status NCT03466632 Phase 3 Propofol;Dexmedetomidine
5 Evaluation of PillCam™ Colon 2 in Visualization of the Colon Completed NCT01063231 Phase 3
6 Evaluation of PillCam™ Colon Capsule Endoscopy (PCCE) in the Visualization of the Colon Completed NCT00604162 Phase 3
7 A Prospective, Randomized, Parallel, Multi-center, Phase 3 Trial to Evaluate Safety and Efficacy of PBK-1701TC Completed NCT03509220 Phase 3 PBK-1701TC;Standard oral preparation
8 Evaluation of the PillCam™ Colon Capsule Endoscopy (PCCE) Night Procedure Completed NCT00951587 Phase 3
9 Multicenter Trial of Functional Bowel Disorders Completed NCT00006157 Phase 3 Desipramine
10 Peppermint Oil for the Treatment of Irritable Bowel Syndrome: Optimizing Therapeutic Strategies Using Targeted Delivery Completed NCT02716285 Phase 3 Ileocolonic release peppermint oil;Placebo;Small intestinal release peppermint oil
11 Improvement of Tolerability for Bowel Preparation for Colonoscopy in Diabetic Patients. A Randomized Controlled Trial of Two Bowel Preparation Protocols Including 4 Liters PEG vs. 2 Liters PEG Plus Ascorbic Acid. iDIMEPREP Study. Completed NCT02297399 Phase 3 PEG-ascorbate 2L;PEG 4L
12 A Prospective, Randomized, Single-blinded (Evaluator), 3-treatment Arm, Parallel, Multi-center, Phase 3 Trial to Evaluate Safety and Efficacy of CDFR0612 and CDFR0613 Completed NCT02304523 Phase 3 CDFR0612;CDFR0613;Coolprep Powder
13 Randomized Clinical Trial on the Efficacy of an Adapted Bowel Preparation for Diabetic Patients Undergoing a Colonoscopy. DIMEPREP Study Completed NCT02300779 Phase 3
14 Prospective Phase II Randomized Trial of Postoperative Adjuvant Chemotherapy in Patients With High Risk Colon Cancer Unknown status NCT00201331 Phase 2 leucovorin+5-FU
15 Clinical Study to Test the Efficacy of Herbal Medicine in Relieving Symptoms and Change of Quality of Life of Patients With IBS Completed NCT00153751 Phase 2 Traditional Chinese Medicine;Holopon
16 Randomised, Controlled Trial of Intravenous Saline Pre-hydration in Patients Undergoing Outpatient Colonoscopy Completed NCT00308152 Phase 2 Infusion of 1 litre of normal saline before colonoscopy
17 The Effect of Kyo-Dophilus 1.5 Billion on the Symptoms of Severe Irritable Bowel Syndrome Completed NCT01887834 Phase 1, Phase 2
18 The Effect of Kyo-Dophilus 1.5 Billion on the Symptoms of Irritable Bowel Syndrome (IBS) Completed NCT01176227 Phase 1, Phase 2
19 A Randomized, Double Blind, Single Dose, Two Treatment, Two Period Crossover Pharmacokinetic Study Comparing a 182mg Colon-targeted-delivery Peppermint Oil Capsule (Tempocol-ColoPulse®) and a 182mg Enteric-coated Peppermint Oil Capsule (Tempocol®) in Healthy Volunteers Completed NCT02291445 Phase 2 Menthae piperitae aetheroleum/peppermint oil (enteric coated capsule);Menthae piperitae aetheroleum/peppermint oil (colon-targeted-delivery capsule)
20 A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of TRN 002 (Crofelemer) for the Symptomatic Treatment of Diarrhea-Predominant Irritable Bowel Syndrome (d-IBS) Completed NCT00101725 Phase 2 crofelemer
21 A Randomized, Double-Blind, Placebo-Controlled, Phase 2a Proof-of-Concept Study of GIC-1001 for the Management of Visceral Pain in Subjects Undergoing Sedation-Free, Full Colonoscopy Completed NCT01926444 Phase 2 GIC-1001
22 A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Multiple Ascending Dose Study (Induction Therapy) & Long-term Extension Therapy of an Anti-OX40 Monoclonal Antibody (KHK4083) in Subjects With Moderately Active UC Completed NCT02647866 Phase 2 KHK4083;Placebo
23 Evaluation of the Effect of the Ocoxin®-Viusid® Nutritional Supplement on the Quality of Life of Patients With Metastatic Colorectal Adenocarcinoma. Phase II Recruiting NCT03559543 Phase 2
24 A Phase 1/2 Study of the Highly-selective RET Inhibitor, BLU-667, in Patients With Thyroid Cancer, Non-Small Cell Lung Cancer (NSCLC) and Other Advanced Solid Tumors Recruiting NCT03037385 Phase 1, Phase 2 pralsetinib (BLU-667)
25 An Open, Single Arm, Multicenter, Exploratory Phase II Clinical Trial of Anlotinib Hydrochloride Capsules Combined With CAPEOX in RAS and BRAF Wild-type Patients With Metastatic Colorectal Carcinoma as 1st Therapy Recruiting NCT04080843 Phase 2 Anlotinib Hydrochloride;Capecitabine;Oxaliplatin
26 A Phase I/II Study of Pembrolizumab in Combination With Ibrutinib for Advanced, Refractory Colorectal Cancers Active, not recruiting NCT03332498 Phase 1, Phase 2 Pembrolizumab;Ibrutinib
27 A Phase I, Double-Blind, Placebo-Controlled, Randomized, Parallel-Group Study to Evaluate the Safety and Efficacy of a Combination Herbal Therapy (CHT), Versus Placebo in Improving the Overall Quality of Life and Symptoms in Patients With Irritable Bowel Syndrome (IBS) Completed NCT00130741 Phase 1 CHT - herbal therapy
28 A Double-Blind, Placebo Controlled, Phase I Study to Assess Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Oral Doses of GIC-1001 in Normal Healthy Volunteers Completed NCT01738425 Phase 1 GIC-1001; 125 mg oral tablets;GIC-1001 matching placebo
29 A Phase 1b Clinical Study on the Analgesic Effect of GIC-1001 and GIC-1002 on Visceral Pain Under Rectal Distension and Rectal Sensory Threshold Using the Barostat Method in Male and Female Healthy Volunteers. Completed NCT02276768 Phase 1 GIC-1001 375 mg TID;GIC-1001 500 mg TID;GIC-1002 345 mg TID (equimolar to GIC-1001 375 mg TID);GIC-1002 460 mg (equimolar to GIC-1001 500 mg)
30 Which Position is Suitable for Easy, Fast and Comfortable Colonoscopy Unknown status NCT03854422
31 Yield of Colonoscopy in Children With Bleeding Per Rectum Attending Gastrointestinal Endoscopic Unit In Assuit University Children Hospital Unknown status NCT03596320
32 A Prospective, Single Center, Single-blinded, Randomized Study, of the Angel of Water™ for Colon Cleansing as Preparation for Colonoscopy Unknown status NCT01871584
33 Water Injection Colonoscopy vs Air Insufflation Colonoscopy in Experienced Endoscopists Unknown status NCT01797406
34 Water Injection Colonoscopy vs Air Insufflation Colonoscopy in Training the Beginners Unknown status NCT01762735
35 "Air Assisted"Water Injection Colonoscopy in Experienced Endoscopists Unknown status NCT01797393
36 Ultrafine Endoscope for Unsedated Colonoscopy is an Effective Method to Reduce Abdominal Pain:a Prospective Randomized Study. Unknown status NCT02160210
37 Screening and Identification of Abnormal Expression Proteins and miRNA From Colonic Mucosa of Patients With Irritable Bowel Syndrome. Unknown status NCT01028898
38 Evaluation of Microcirculation in Colon Wall and Bowel Anastomosis by Laser Induced Fluorescence Video Angiography of Indocyanine Green Unknown status NCT01419860 Early Phase 1
39 Translation of Colorectal Cancer Screening Guidelines: A System Intervention Completed NCT00122187
40 Does a Daily Dose of the Probiotic Lactobacillus Casei Shirota Prevent Acute Episodes of Diverticulitis (LACTOPRoD) - a Pilot Study Completed NCT01609751
41 Could Lumbo-sacral Magnetic Stimulation Modify Recto-colonic Motility? Completed NCT00213317
42 Influence of Adequacy of Anaesthesia Monitoring on Both Operators' and Patients' Satisfaction in Patients Undergoing Colonoscopic Procedures Completed NCT03922815 rescue fentanyl;rescue propofol
43 Dietary Interventions in Irritable Bowel Syndrome: Soluble, Insoluble or no Fibre? A Randomized Controlled Trial in Primary Care. Completed NCT00189033 psyllium fibre (dietary supplement);wheat bran (dietary supplement);rice wheat (placebo)
44 Effect of Galacto-Oligosaccharides Supplementation on Amoxicillin-treated Gut Microbiota From Healthy Adults : a Proof of Principal Study Completed NCT01848535
45 The Challenge of Assessing Infectious Risk and Visceral Closure in NOTES: A Prospective Study Examining Routine Colorectal Surgery as a Model in Humans Completed NCT01102725
46 Evaluation of PillCam™ Colon 2 in Visualization of the Colon Completed NCT01087528
47 Gene Expression Analysis of Patients With Metastatic Colorectal Cancer Receiving Oxaliplatin Based Chemotherapy Completed NCT00250029 Oxaliplatin
48 The Impact of Diet Liberalization on Bowel Preparation for Colonoscopy Completed NCT01876576
49 The Impact of Trendelenberg Positioning as Compared to Left Lateral Positioning on Ease of Colonoscope Insertion During Colonoscopy Completed NCT02519686
50 A Randomized Trial Comparing Outcomes for the LigaSure and Disposable Stapling Instruments for Laparoscopic Surgery Completed NCT00487409

Search NIH Clinical Center for Colonic Disease

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Scopolamine
Scopolamine Hydrobromide

Cochrane evidence based reviews: colonic diseases

Genetic Tests for Colonic Disease

Anatomical Context for Colonic Disease

MalaCards organs/tissues related to Colonic Disease:

40
Colon, Thyroid, Small Intestine, Lymph Node, Skin, Neutrophil, Smooth Muscle

Publications for Colonic Disease

Articles related to Colonic Disease:

(show top 50) (show all 1206)
# Title Authors PMID Year
1
Propensity score-matched comparison of stenting as a bridge to surgery and emergency surgery for acute malignant left-sided colonic obstruction. 42
33743658 2021
2
The gut microbiota and colorectal surgery outcomes: facts or hype? A narrative review. 42
33579260 2021
3
Toll-like receptor 4 regulates intestinal fibrosis via cytokine expression and epithelial-mesenchymal transition. 42
33199767 2020
4
Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohn's disease in an Australian population. 54 61
18213697 2008
5
Reducing Underdiagnosis of Hirschsprung-Associated Enterocolitis: A Novel Scoring System. 61
33460971 2021
6
Intrinsic cholinergic innervation in the human sigmoid colon revealed using CLARITY, three-dimensional (3D) imaging, and a novel anti-human peripheral choline acetyltransferase (hpChAT) antiserum. 61
33174295 2021
7
Roles of the Polyphenol-Gut Microbiota Interaction in Alleviating Colitis and Preventing Colitis-Associated Colorectal Cancer. 61
32905583 2021
8
Prospective single-blinded single-center randomized controlled trial of Prep Kit-C and Moviprep: Does underlying inflammatory bowel disease impact tolerability and efficacy? 61
33776375 2021
9
Quantitative analysis of enteric neurons containing choline acetyltransferase and nitric oxide synthase immunoreactivities in the submucosal and myenteric plexuses of the porcine colon. 61
32965550 2021
10
Drug Disposition in the Lower Gastrointestinal Tract: Targeting and Monitoring. 61
33530468 2021
11
Chemoprevention in familial adenomatous polyposis: past, present and future. 61
32507936 2021
12
Predicting Outcomes in Pediatric Crohn's Disease for Management Optimization: Systematic Review and Consensus Statements From the Pediatric Inflammatory Bowel Disease-Ahead Program. 61
32979356 2021
13
Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection. 61
33479474 2021
14
COULD THE INTESTINAL EPITHELIAL ALTERATIONS PROMOTED BY ROUX-EN-Y GASTRIC BYPASS EXPLAIN HIGHER TENDENCY FOR COLONIC DISEASES IN BARIATRIC PATIENTS? 61
33759960 2021
15
Are clarithromycin, azithromycin and their analogues effective in the treatment of COVID19? 61
33502877 2021
16
Comparison of primary anastomosis and staged surgery in emergency treatment of complicated Crohn's disease. 61
33012107 2020
17
Impact of protein on the composition and metabolism of the human gut microbiota and health. 61
33349284 2020
18
Preoperative heat shock protein 47 levels identify colorectal cancer patients with lymph node metastasis and poor prognosis. 61
33123244 2020
19
Keratin intermediate filaments in the colon: guardians of epithelial homeostasis. 61
33152513 2020
20
Effects of Vitamin D3 on Intestinal Flora in a Mouse Model of Inflammatory Bowel Disease Treated with Rifaximin. 61
33177483 2020
21
Microbiota changes induced by microencapsulated sodium butyrate in patients with inflammatory bowel disease. 61
32476236 2020
22
Paediatric inflammatory bowel disease in India: a prospective multicentre study. 61
32796356 2020
23
Observer agreement for small bowel ultrasound in Crohn's disease: results from the METRIC trial. 61
32037466 2020
24
Prevalence of Organic Colonic Lesions by Colonoscopy in Patients with Irritable Bowel Syndrome Fulfilling Rome III Criteria. 61
33116096 2020
25
Can 2 Different Fecal Calprotectin Assays be Used Interchangeably in IBD Treatment? 61
33116067 2020
26
Decreased number of colonic tuft cells in quiescent ulcerative colitis patients. 61
33079783 2020
27
Update on SLC6A14 in lung and gastrointestinal physiology and physiopathology: focus on cystic fibrosis. 61
32166393 2020
28
Diffusion-weighted magnetic resonance for assessing fibrosis in Crohn's disease. 61
31392397 2020
29
Upper Gastrointestinal Disease Influences the Occurrence of Inflammatory Bowel Disease. 61
31776861 2020
30
Role of Inflammation in Pathophysiology of Colonic Disease: An Update. 61
32635383 2020
31
Which is the Optimal Method of Reconstruction After Laparoscopic Right Hemicolectomy, the Intracorporeal or Extracorporeal Anastomosis Technique? 61
32876023 2020
32
Early Combined Immunosuppression May Be More Effective for Reducing Complications in Isolated Colonic- vs Ileal-Dominant Crohn Disease. 61
32592481 2020
33
Post-Translational Modifications of Transcription Factors Harnessing the Etiology and Pathophysiology in Colonic Diseases. 61
32369982 2020
34
Trans-stomal single-port laparoscopic Hartmann's reversal is an efficacious and efficient procedure: a case-controlled study. 61
32200457 2020
35
A case report of iatrogenic gas gangrene post colonoscopy successfully treated with conservative management- is surgery always necessary? 61
32460761 2020
36
Ileal or Colonic Histologic Activity Is Not Associated With Clinical Relapse in Patients With Crohn's Disease in Endoscopic Remission. 61
32360823 2020
37
In vitro release kinetics of graft matrices from Lannea coromandelica (Houtt) gum for treatment of colonic diseases by 5-ASA. 61
32027894 2020
38
Is fecal calprotectin an accurate marker in the management of Crohn's disease? 61
31795013 2020
39
Proteomics Highlights Common and Distinct Pathophysiological Processes Associated with Ileal and Colonic Ulcers in Crohn's Disease. 61
31282946 2020
40
The xenobiotic sensing pregnane X receptor regulates tissue damage and inflammation triggered by C difficile toxins. 61
31907988 2020
41
High-Fat Diet Propelled AOM/DSS-Induced Colitis-Associated Colon Cancer Alleviated by Administration of Aster glehni via STAT3 Signaling Pathway. 61
32024285 2020
42
A comparative study of hyperelastic constitutive models for colonic tissue fitted to multiaxial experimental testing. 61
31877516 2020
43
Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements. 61
31952340 2020
44
Inulin as a Delivery Vehicle for Targeting Colon-Specific Cancer. 61
32459607 2020
45
The surprise pathology-Primary squamous cell carcinoma of the colon-A case report. 61
32516701 2020
46
Audit of the impact of the York faecal calprotectin care pathway on colonoscopy activity. 61
32587672 2020
47
Management of the Elderly Inflammatory Bowel Disease Patient. 61
31935714 2020
48
Platelet-to-lymphocyte percentage ratio index: a simple non-invasive index to monitor the endoscopic activity in Crohn's disease. 61
33425010 2020
49
Korean Children and Adolescents with Crohn's Disease Are More Likely to Present with Perianal Fistulizing Disease at Diagnosis Compared to Their European Counterparts. 61
31988875 2020
50
Correlation of Stool Frequency and Abdominal Pain Measures With Simple Endoscopic Score for Crohn's Disease. 61
31644790 2020

Variations for Colonic Disease

Expression for Colonic Disease

Search GEO for disease gene expression data for Colonic Disease.

Pathways for Colonic Disease

Pathways related to Colonic Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.16 STAT3 JAK1 ESR1 CTSD
2 11.96 STAT3 MIR9-1 MIR31 MIR30A MIR21 MIR200A
3 11.36 MIR30A MIR18A MIR17
4 10.91 STAT3 MIR9-1 MIR199A1
5 10.7 NOD2 ESR1 APC
6 10.48 MIR199A1 MIR145
7 10.44 STAT3 ESR1

GO Terms for Colonic Disease

Cellular components related to Colonic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.81 MIR9-1 MIR21 MIR17 MIR155 MIR145 MIR143
2 extracellular space GO:0005615 9.32 MIR31 MIR30A MIR21 MIR199A1 MIR18A MIR17
3 extracellular vesicle GO:1903561 9.26 MIR30A MIR21 MIR17 MIR125A

Biological processes related to Colonic Disease according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.95 MIR21 MIR17 MIR155 MIR125A ESR1
2 positive regulation of protein kinase B signaling GO:0051897 9.91 MIR21 MIR199A1 MIR143 ESR1
3 negative regulation of angiogenesis GO:0016525 9.84 MIR21 MIR145 MIR143 MIR125A
4 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.83 NOD2 MIR21 MIR155
5 positive regulation of fibroblast proliferation GO:0048146 9.77 MIR17 MIR155 ESR1
6 positive regulation of interleukin-10 production GO:0032733 9.74 STAT3 NOD2 MIR145
7 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.73 MIR21 MIR199A1 MIR145
8 positive regulation of blood vessel endothelial cell migration GO:0043536 9.73 MIR31 MIR30A MIR200A MIR143
9 negative regulation of vascular endothelial growth factor production GO:1904046 9.7 MIR199A1 MIR17 MIR125A
10 positive regulation of connective tissue replacement GO:1905205 9.66 MIR199A1 MIR155
11 negative regulation of hydrogen peroxide-induced cell death GO:1903206 9.66 MIR17 MIR155
12 negative regulation of cytokine-mediated signaling pathway GO:0001960 9.65 MIR21 MIR125A
13 interleukin-15-mediated signaling pathway GO:0035723 9.65 STAT3 JAK1
14 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.65 MIR199A1 MIR17 MIR155
15 interleukin-35-mediated signaling pathway GO:0070757 9.64 STAT3 JAK1
16 interleukin-27-mediated signaling pathway GO:0070106 9.64 STAT3 JAK1
17 angiotensin-activated signaling pathway GO:0038166 9.63 MIR145 MIR143
18 interleukin-9-mediated signaling pathway GO:0038113 9.63 STAT3 JAK1
19 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.63 MIR199A1 MIR17 MIR155
20 positive regulation of angiogenesis GO:0045766 9.63 STAT3 MIR31 MIR30A MIR21 MIR199A1 MIR143
21 negative regulation of regulatory T cell differentiation GO:0045590 9.62 MIR21 MIR155
22 interleukin-21-mediated signaling pathway GO:0038114 9.62 STAT3 JAK1
23 positive regulation of sprouting angiogenesis GO:1903672 9.62 MIR31 MIR155 MIR125A JAK1
24 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.61 MIR21 MIR17
25 aorta smooth muscle tissue morphogenesis GO:0060414 9.59 MIR145 MIR143
26 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.58 MIR17 MIR143
27 regulation of phenotypic switching GO:1900239 9.58 MIR145 MIR143
28 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.58 MIR31 MIR155 MIR125A
29 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.56 STAT3 NOD2 MIR21 MIR17
30 positive regulation of metalloendopeptidase activity GO:1904685 9.54 STAT3 MIR21 MIR17
31 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 9.51 MIR145 MIR143
32 negative regulation of interleukin-16 production GO:0032699 9.49 MIR145 MIR125A
33 miRNA mediated inhibition of translation GO:0035278 9.43 MIR9-1 MIR31 MIR21 MIR17 MIR155 MIR145
34 gene silencing by miRNA GO:0035195 9.4 MIR9-1 MIR31 MIR30A MIR21 MIR200A MIR199A1

Molecular functions related to Colonic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.56 MIR9-1 MIR31 MIR30A MIR21 MIR17 MIR145
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.4 MIR9-1 MIR31 MIR30A MIR21 MIR200A MIR199A1
3 CCR5 chemokine receptor binding GO:0031730 9.16 STAT3 JAK1

Sources for Colonic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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