Aliases & Classifications for Colonic Disease

MalaCards integrated aliases for Colonic Disease:

Name: Colonic Disease 12 15
Colonic Diseases 55 43 44 73
Colon Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5353
MeSH 44 D003108
SNOMED-CT 68 128524007
UMLS 73 C0009373

Summaries for Colonic Disease

MedlinePlus : 43 Your colon, also known as the large intestine, is part of your digestive system. It's a long, hollow tube at the end of your digestive tract where your body makes and stores stool. Many disorders affect the colon's ability to work properly. Some of these include Colorectal cancer Colonic polyps - extra tissue growing in the colon that can become cancerous Ulcerative colitis - ulcers of the colon and rectum Diverticulitis - inflammation or infection of pouches in the colon Irritable bowel syndrome - an uncomfortable condition causing abdominal cramping and other symptoms Treatment for colonic diseases varies greatly depending on the disease and its severity. Treatment may involve diet, medicines and in some cases, surgery. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Colonic Disease, also known as colonic diseases, is related to megacolon and functional colonic disease, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Colonic Disease is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Neural Crest Differentiation. The drugs Capecitabine and Zinc have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Colonic Disease

Diseases related to Colonic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 megacolon 26.2 ACHE EDN3 EDNRB GDNF GFRA1 NRTN
2 functional colonic disease 11.9
3 endometrial clear cell adenocarcinoma 10.7 CTSD ESR1
4 diverticulitis of colon 10.7
5 waardenburg syndrome, type 2e 10.5 EDNRB SOX10
6 medullary sponge kidney 10.5 GDNF RET
7 waardenburg syndrome, type 1 10.4 EDN3 SOX10
8 waardenburg syndrome type 4 10.4 EDN3 EDNRB SOX10
9 cochlear disease 10.3 EDN3 EDNRB SOX10
10 intestinal pseudo-obstruction 10.3 EDNRB RET SOX10
11 tietz albinism-deafness syndrome 10.2 EDN3 SOX10
12 intestinal disease 10.2 EDNRB NOD2 RET STAT3
13 lichen nitidus 10.1 RET UCHL1
14 hypoganglionosis 10.1 ACHE GDNF RET
15 thyroid cancer, nonmedullary, 2 10.1 EDNRB GDNF RET
16 mowat-wilson syndrome 10.1 EDNRB ZEB2
17 atypical neurofibroma 10.1 SOX10 UCHL1
18 waardenburg syndrome, type 4a 10.1 EDN3 EDNRB RET SOX10
19 multiple endocrine neoplasia, type iia 10.0 GDNF GFRA1 RET
20 waardenburg's syndrome 10.0 EDN3 EDNRB RET SOX10
21 autonomic nervous system disease 10.0 ASCL1 EDNRB PHOX2B
22 constipation 9.9 EDN3 EDNRB GDNF RET
23 multiple endocrine neoplasia, type iib 9.8 EDNRB GDNF GFRA1 RET
24 thyroid carcinoma, familial medullary 9.7 EDNRB GDNF GFRA1 RET
25 crohn's disease 9.7
26 jejunoileitis 9.6 GDNF GFRA1
27 cholangitis, primary sclerosing 9.5
28 ulcerative colitis 9.5
29 colitis 9.5
30 mucositis 9.5
31 sclerosing cholangitis 9.5
32 cholangitis 9.5
33 cystic fibrosis 9.4
34 enterocolitis 9.4
35 pancreatic cancer 9.4
36 aging 9.4
37 epidermolysis bullosa dystrophica 9.4
38 hepatitis 9.4
39 familial adenomatous polyposis 9.4
40 inflammatory bowel disease 9.4
41 portal hypertension 9.4
42 epidermolysis bullosa 9.4
43 ischemia 9.4
44 merkel cell carcinoma 9.4
45 pancreatitis 9.4
46 perinatal necrotizing enterocolitis 9.4
47 tetraploidy 9.4
48 goldberg-shprintzen syndrome 9.4 ASCL1 EDN3 EDNRB GDNF RET
49 central hypoventilation syndrome, congenital 9.0 ASCL1 EDN3 EDNRB GDNF PHOX2B RET
50 intestinal obstruction 8.3 ACHE EDN3 EDNRB GDNF NOD2 NRTN

Graphical network of the top 20 diseases related to Colonic Disease:



Diseases related to Colonic Disease

Symptoms & Phenotypes for Colonic Disease

UMLS symptoms related to Colonic Disease:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

GenomeRNAi Phenotypes related to Colonic Disease according to GeneCards Suite gene sharing:

26 (show all 28)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.85 ZEB2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.85 SOX10
3 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.85 CTSD
4 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.85 ZEB2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.85 SOX10 CTSD
6 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.85 STAT3 ZEB2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.85 STAT3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.85 RET
9 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.85 RET
10 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.85 CTSD
11 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.85 ZEB2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.85 RET
13 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.85 ZEB2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.85 RET
15 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.85 SOX10
16 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.85 RET
17 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.85 SOX10
18 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.85 SOX10
19 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.85 RET
20 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.85 CTSD
21 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.85 ZEB2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.85 SOX10
23 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.85 SOX10
24 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.85 RET CTSD
25 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.85 SOX10
26 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.85 RET SOX10 STAT3 ZEB2 CTSD
27 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.85 CTSD
28 Decreased Aire reporter expression GR00304-A 9.26 ASCL1 ESR1 SOX10 ZEB2

MGI Mouse Phenotypes related to Colonic Disease:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.41 STAT3 UCHL1 ACHE ASCL1 CTSD EDN3
2 cellular MP:0005384 10.36 ASCL1 CTSD EDNRB ESR1 GDNF GFRA1
3 growth/size/body region MP:0005378 10.34 UCHL1 ZEB2 ACHE ASCL1 CTSD EDNRB
4 digestive/alimentary MP:0005381 10.31 CTSD EDN3 EDNRB ESR1 GDNF GFRA1
5 mortality/aging MP:0010768 10.31 NOD2 PHOX2B RET SOX10 STAT3 UCHL1
6 nervous system MP:0003631 10.22 KIDINS220 NRTN PHOX2B RET SOX10 STAT3
7 embryo MP:0005380 10.18 EDN3 EDNRB ESR1 GFRA1 PHOX2B RET
8 cardiovascular system MP:0005385 10.16 EDNRB ESR1 GDNF KIDINS220 PHOX2B RET
9 endocrine/exocrine gland MP:0005379 10.16 ASCL1 CTSD EDNRB ESR1 GDNF NRTN
10 hematopoietic system MP:0005397 10.13 GDNF NOD2 RET STAT3 UCHL1 ACHE
11 immune system MP:0005387 10.11 CTSD EDNRB ESR1 GDNF GFRA1 NOD2
12 integument MP:0010771 10.09 ASCL1 CTSD EDN3 EDNRB ESR1 GFRA1
13 muscle MP:0005369 9.97 RET STAT3 ACHE EDNRB ESR1 GDNF
14 no phenotypic analysis MP:0003012 9.8 ACHE ASCL1 ESR1 KIDINS220 RET SOX10
15 renal/urinary system MP:0005367 9.7 EDNRB ESR1 GDNF GFRA1 RET STAT3
16 respiratory system MP:0005388 9.61 ACHE ASCL1 EDNRB ESR1 PHOX2B RET
17 vision/eye MP:0005391 9.28 NRTN PHOX2B STAT3 ZEB2 ACHE ASCL1

Drugs & Therapeutics for Colonic Disease

Drugs for Colonic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 923)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 154361-50-9 60953
2
Zinc Approved, Investigational Phase 4,Not Applicable 7440-66-6 23994
3
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
4
Tegafur Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 17902-23-7 5386
5
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
6
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 50-23-7 5754
7
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 170277-31-3
8
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 169590-42-5 2662
9
Erythromycin Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 114-07-8 12560
10
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6 772 46507594
11
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 97682-44-5, 100286-90-6 60838
12
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 564-25-0 54671203
13
Iron Approved Phase 4,Phase 3,Phase 2,Not Applicable 7439-89-6 23925
14
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-78-2 2244
15
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
16
Amitriptyline Approved Phase 4 50-48-6 2160
17
Midazolam Approved, Illicit Phase 4,Phase 1,Not Applicable 59467-70-8 4192
18
Iodine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 7553-56-2 807
19
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
20
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
21
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 61825-94-3 5310940 9887054 43805 6857599
22
Citalopram Approved Phase 4,Phase 3,Phase 2 59729-33-8 2771
23
Loperamide Approved Phase 4,Phase 2,Phase 3,Not Applicable 53179-11-6 3955
24
Curcumin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 458-37-7 969516
25
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable,Early Phase 1 2078-54-8 4943
26
Cetuximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 205923-56-4 56842117 2333
27
Perphenazine Approved Phase 4 58-39-9 4748
28
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 331731-18-1 16219006
29
Azathioprine Approved Phase 4,Phase 3,Not Applicable 446-86-6 2265
30
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
31
Pentoxifylline Approved, Investigational Phase 4,Phase 2 6493-05-6 4740
32
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable,Early Phase 1 437-38-7 3345
33
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
34
Raltitrexed Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 112887-68-0 104758
35
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 51-21-8 3385
36
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 216974-75-3
37
Rifaximin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 80621-81-4 6436173
38
Epirubicin Approved Phase 4,Phase 2 56420-45-2 41867
39
Pancrelipase Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 53608-75-6
40
Aminosalicylic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 65-49-6 4649
41
Ethiodized oil Approved, Investigational Phase 4,Phase 2 8008-53-5
42
Bisacodyl Approved Phase 4,Not Applicable 603-50-9
43
Levoleucovorin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 68538-85-2
44
Nicotine Approved Phase 4,Phase 3,Not Applicable 54-11-5 942 89594
45
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 85721-33-1 2764
46
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable,Early Phase 1 28523-86-6 5206
47
Bupivacaine Approved, Investigational Phase 4,Phase 2,Not Applicable 2180-92-9, 38396-39-3 2474
48
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
49
Dopamine Approved Phase 4,Phase 2,Not Applicable 51-61-6, 62-31-7 681
50
Ketorolac Approved Phase 4,Not Applicable 74103-06-3, 66635-83-4 3826

Interventional clinical trials:

(show top 50) (show all 5100)
# Name Status NCT ID Phase Drugs
1 Multidisciplinary Approach Versus Conventional Approach in Colonic Preparation of Hospitalized Patients Unknown status NCT01853709 Phase 4 Polyethylene glycol (PEG);Bisacodyl
2 The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Taking Aspirin Unknown status NCT01549418 Phase 4 Aspirin (ASA);Placebo
3 Safety and Therapeutic Efficacy of Phosphate Enema (Kleen Enema) in Patients Undergoing Sigmoidoscopy Unknown status NCT02386904 Phase 4 Phosphate Enema (Kleen® Enema)
4 The Efficacy of Hydrolyzed Guar Gum ( PHGG) in the Treatment of Patients With Irritable Bowel Syndrome (IBS) Unknown status NCT01779765 Phase 4
5 Changes in Gastrointestinal Microbiota Using VSL#3 in Patients With IBS-D Unknown status NCT01638208 Phase 4 VSL#3
6 "Efficacy and Safety of Infliximab-biosimilar (Inflectra) Compared to Infliximab-innovator (Remicade) in Patients With Inflammatory Bowel Disease in Remission: the SIMILAR Trial" Unknown status NCT02452151 Phase 4 Infliximab-Biosimilar;Infliximab-Innovator
7 The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of Inflammation Unknown status NCT01078935 Phase 4
8 Effect of Clostridium Butyricum in Treating Irritable Bowel Syndrome Unknown status NCT02614963 Phase 4 Clostridium Butyricum;placebo
9 Pain Relief In Irritable Bowel Syndrome Unknown status NCT02573844 Phase 4 Proklama
10 Is Microbiota Community Associated With Clinical Response to a Low FODMAP Diet in Patients With Irritable Bowel Syndrome Unknown status NCT02565550 Phase 4
11 Comparison of the Efficacy and Safety of Tiropramide and Octylonium in the Treatment of Irritable Bowel Syndrome Unknown status NCT01629212 Phase 4 Tiropramide HCl 100mg;Octylonium bromide 20mg
12 Effect of Pentoxifylline on Tight Junctions (TJs) of Intestinal Mucosa in Patients With Irritable Bowel Syndrome(IBS) Unknown status NCT01542268 Phase 4 pentoxifylline;pentoxifylline placebo
13 Lactibiane Tolérance® in Individuals Suffering From Irritable Bowel Syndrome With Diarrheal Predominance Unknown status NCT02728063 Phase 4
14 Effect of Mosapride on Gut Transit in Patients With Chronic Constipation or Constipated Irritable Bowel Syndrome and Healthy Subjects Unknown status NCT02433847 Phase 4 Mosapride
15 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
16 Saccharomyces Boulardii in Diarrhea Dominant Irritable Bowel Syndrome Unknown status NCT00543478 Phase 4 Saccharomyces boulardii;Methyl cellulose powder (low viscosity)
17 A Randomized, Multicenter Open Label Study Comparing Early Administration of Azathioprine Plus IFX to Steroids Plus Azathioprine for Acute Severe Colitis Unknown status NCT02425852 Phase 4 Azathioprine;Infliximab;Prednisolone;Hydrocortisone
18 Golimumab in Steroid-dependent Ulcerative Colitis: Induction and Maintenance of Clinical and Endoscopic Remission Unknown status NCT02412085 Phase 4 Golimumab
19 Physiological Intermolecular Modification Spectroscopy (PIMS) in Ulcerative Colitis With Golimumab Unknown status NCT02186886 Phase 4 Golimumab
20 Clostridial Infection and Oral Lavage -Improving Treatment Before Illness Becomes Severe Unknown status NCT01630096 Phase 4 Nu-Lytely
21 Role of Healthy Bacteria in Ulcerative Colitis Unknown status NCT01479660 Phase 4 Probiotic
22 Oxaliplatin and Raltitrexed Treatment of Colorectal Cancer With Liver Metastases Unknown status NCT02557490 Phase 4 oxaliplatin and raltitrexed
23 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-minors' Adjusted Version Unknown status NCT02354560 Phase 4 Erythromycin
24 Trial Comparing Ferric(III)Carboxymaltose Infusion With Oral Iron Suppletion as Treatment of Anaemia Unknown status NCT02243735 Phase 4 Ferrous fumarate;ferric(III)carboxymaltose
25 Effect of Omega-3 Fatty Acids on the Perioperative Immune Response and Erythrocyte Function Unknown status NCT02231203 Phase 4 Omegaven;Placebo
26 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis Unknown status NCT02175914 Phase 4 Erythromycin
27 Intraoperative Intraportal Chemotherapy Combined With Adjuvant Chemotherapy for Stage II and III Colorectal Cancer Unknown status NCT01972503 Phase 4 5-FU and oxaliplatin
28 Avastin in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01972490 Phase 4 avastin+chemotherapy of mFOLFOX6 or FOLFIRI;chemotherapy of mFOLFOX6 or FOLFIRI
29 NK Activity Modulation Induced by Intravenous Lidocaine During Colorectal Laparoscopic Surgery Unknown status NCT01841294 Phase 4 Intravenous Lidocaine;Normal saline infusion
30 Participation and Detection Rate Diagnostic of a Colorectal Cancer Screening Program: CT Colonography vs. Flexible Sigmoidoscopy Unknown status NCT01739608 Phase 4
31 Efficacy and Patient Satisfaction of Miralax and Gatorade Versus Movi Prep Unknown status NCT01695863 Phase 4 comparing 2 drugs on their effect on the bowel preparation for colonoscopy
32 Cetuximab in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01564810 Phase 4 Cetuximab;chemotherapy of mFOLFOX6 or FOLFIRI
33 FOLFIRI in Combination With Cetuximab in the First-line Treatment of Metastatic Colorectal Cancer Including a Regular Dermal Prophylaxis to Prevent Acneiforme Follicular Exanthema Unknown status NCT01315990 Phase 4 FOLFIRI + Cetuximab
34 New Adjuvant Chemotherapy of Non Resectable Liver Metastasis of Colorectal Cancer Without Bleeding, Obstruction Unknown status NCT01307878 Phase 4 chemotherapy ± targeted therapy
35 OPTIMOX1 in Chinese mCRC Patients Unknown status NCT01023633 Phase 4 Oxaliplatin, LV, 5-FU
36 Preoperative Transhepatic Arterial Chemotherapy (TAC) in the Treatment of Liver Metastasis of Resectable Colorectal Cancer Unknown status NCT00874406 Phase 4 tac + folfox4;folfox4
37 Transhepatic Arterial Chemotherapy (TAC) Versus Transcatheter Arterial Chemoembolization (TACE) Plus Folfox4 as the Treatment of Unresectable Liver Metastasis of Colorectal Cancer Unknown status NCT00868569 Phase 4
38 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
39 Preoperative Assessment of Colon Tumor Unknown status NCT00114829 Phase 4
40 Study to Evaluate the Duration of Treatment With Ertapenem in Acute Attacks of Sigmoid Diverticulitis Unknown status NCT00097734 Phase 4 ertapenem
41 Endoscopic Detection of Dysplasia in Crohn 's Disease Patient Completed NCT01180452 Phase 4
42 A Study to Evaluate Efficacy of Ramosetron on Diarrhea-predominant Irritable Bowel Syndrome (IBS) in Male Patients Completed NCT01225237 Phase 4 Ramosetron;Placebo
43 A Preliminary Study to Explore Clinical Endpoints in Patients (Male) With Diarrhea-predominant Irritable Bowel Syndrome Completed NCT00918411 Phase 4 Ramosetron;Placebo
44 The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease Completed NCT02010762 Phase 4 Vitamin D;Placebo
45 Effect of Cholecalciferol, Soy Isoflavones in Patients With Irritable Bowel Syndrome Completed NCT02026518 Phase 4
46 Study to Assess the Effect Of Alosetron On Mucosal Blood Flow Completed NCT00370032 Phase 4 alosetron
47 EFESO - EFficacy Enterogermina Small Intestinal Bacterial Overgrowth Completed NCT00331994 Phase 4 Bacillus clausii;Metronidazole
48 Safety of Accelerated Infliximab Infusions in Patients With Inflammatory Bowel Disease (IBD) Completed NCT01346826 Phase 4 Standard 2 hours-infusion;Accelerated 1 hour-infusion;Accelerated 30 minutes-infusion
49 Induction of Immunity Against Streptococcus Pneumoniae in Adults With Inflammatory Bowel Disease Completed NCT01908283 Phase 4
50 The Influence of 5–Aminosalicylates on Thiopurine Metabolite Levels Completed NCT00167882 Phase 4 5-aminosalicylate (Pentasa, Ferring)

Search NIH Clinical Center for Colonic Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: colonic diseases

Genetic Tests for Colonic Disease

Anatomical Context for Colonic Disease

MalaCards organs/tissues related to Colonic Disease:

41
Colon, Liver, Testes, Lung, Breast, T Cells, Skin

Publications for Colonic Disease

Articles related to Colonic Disease:

(show top 50) (show all 89)
# Title Authors Year
1
Pancreatic cancer presenting as colonic disease. A rare case report. ( 29454229 )
2018
2
Reliability of Measuring Ileo-Colonic Disease Activity in Crohn's Disease by Magnetic Resonance Enterography. ( 29361096 )
2018
3
The Growing Utilization of Laparoscopy in Emergent Colonic Disease. ( 29391097 )
2017
4
Therapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseases. ( 27672289 )
2016
5
Advances in colonic disease: some light at the end of the tunnel at the end of the light! ( 26628103 )
2016
6
Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway. ( 26937622 )
2016
7
Colonic disease site and perioperative complications predict need for later intestinal interventions following intestinal resection in pediatric Crohn's disease. ( 26653943 )
2016
8
Single-incision versus standard multi-incision laparoscopic colectomy in patients with malignant or benign colonic disease: a systematic review, meta-analysis and assessment of the evidence. ( 27756272 )
2016
9
Concomitant colonic disease (Montreal L3) and re-resectional surgery are predictors of clinical recurrence following ileocolonic resection for Crohn's disease. ( 26291699 )
2015
10
Robotic versus laparoscopic surgery for colonic disease: a meta-analysis of postoperative variables. ( 25847139 )
2015
11
Enteric infection with Citrobacter rodentium induces coagulative liver necrosis and hepatic inflammation prior to peak infection and colonic disease. ( 22427959 )
2012
12
Is proliferative colonic disease presentation changing? ( 23236236 )
2012
13
The colonic microbiota and colonic disease. ( 22941733 )
2012
14
Merkel cell carcinoma metastatic to the transverse colon: disease free after six years - cure or just prolonged remission? ( 22070707 )
2011
15
Colonic FDG uptake pattern in subjects receiving oral contrast with no known or suspected colonic disease. ( 21825842 )
2011
16
Advanced diagnostic imaging in colonic disease. ( 20190723 )
2010
17
Colonic perforation during barium enema in a patient without known colonic disease: a case report. ( 19918538 )
2009
18
Balsalazide in treating colonic diseases. ( 19708827 )
2009
19
Biochemical and immunohistochemical characterisation of mucins in 8 cases of colonic disease--a pilot study. ( 17969773 )
2007
20
Acute colonic disease: how to image in emergency. ( 17174054 )
2007
21
Death from colonic disease in epidermolysis bullosa dystrophica. ( 16480504 )
2006
22
Colonic perforation at CT colonography in a patient without known colonic disease. ( 16357389 )
2006
23
Coprocytobiology: on the nature of cellular elements from stools in the pathophysiology of colonic disease. ( 12702972 )
2003
24
Cerebrospinal fluid polyamine levels in patients with colonic disease. ( 12567356 )
2003
25
Halo sign: useful CT sign for differentiating benign from malignant colonic disease. ( 12662952 )
2003
26
Interleukin-2-Deficient mice: effect on cytokines and inflammatory cells in chronic colonic disease. ( 11913411 )
2002
27
The course of colonic disease in ulcerative colitis patients with primary sclerosing cholangitis. ( 16378294 )
2002
28
Variability in the severity of colonic disease in familial adenomatous polyposis results from differences in tumour initiation rather than progression and depends relatively little on patient age. ( 11559652 )
2001
29
Apoptotic colonic disease: a new entity in a primate. ( 11286126 )
2001
30
Leiden mutation (as genetic) and environmental (retinoids) sequences in the acute and chronic inflammatory and premalignant colon disease in human gastrointestinal tract. ( 11595480 )
2001
31
Investigation of colonic disease. ( 11103279 )
2000
32
Aberrant crypt foci in patients with neoplastic and nonneoplastic colonic disease. ( 9923929 )
1999
33
Psoas abscesses complicating colonic disease: imaging and therapy. ( 10645182 )
1999
34
Cystic fibrosis: CT findings of colonic disease. ( 9494492 )
1998
35
Diagnosis and treatment of colonic disease in AIDS. ( 9730938 )
1998
36
Colonic disease in cirrhotic patients with portal hypertension: an endoscopic and clinical evaluation. ( 9600375 )
1998
37
Psoas abscesses complicating colonic disease: imaging and therapy. ( 10209409 )
1998
38
Nitric oxide and inflammatory bowel disease: evidence for local intestinal production in children with active colonic disease. ( 9443117 )
1998
39
Does sucrase deficiency in black South Africans protect against colonic disease? ( 9449875 )
1998
40
Pattern of colonic disease in lower gastrointestinal bleeding in Jordanian patients: a prospective colonoscopic study. ( 9075759 )
1997
41
Differences in colonic disease activity in patients with ulcerative colitis with and without primary sclerosing cholangitis: a case control study. ( 9106695 )
1997
42
Analysis of the predictive value of clinical data in patients with suspected colonic disease. ( 9253234 )
1997
43
The different expression of proteins recognized by monoclonal anti-heat shock protein 70 (hsp70) antibody in human colonic diseases. ( 9150951 )
1997
44
Colonic disease associated with a positive assay for Clostridium difficile toxin: a retrospective study. ( 9412955 )
1997
45
A prospective study of abdominal computerized tomography and colonoscopy in the diagnosis of colonic disease in an elderly population. ( 8889456 )
1996
46
Interaction of LS174T human colon cancer cell mucins with Entamoeba histolytica: an in vitro model for colonic disease. ( 8942726 )
1996
47
Expression of binding of plasminogen, thrombospondin, vitronectin, and fibrinogen, and adhesive properties by Escherichia coli strains isolated from patients with colonic diseases. ( 7535283 )
1995
48
Glycosylation patterns of mucins in colonic disease. ( 8654850 )
1995
49
Expression of urokinase-type plasminogen activator and plasminogen activator inhibitor in colon disease. ( 8587011 )
1995
50
Expression of hormone receptors, cathepsin D, and HER-2/neu oncoprotein in normal colon and colonic disease. ( 8099272 )
1993

Variations for Colonic Disease

Expression for Colonic Disease

Search GEO for disease gene expression data for Colonic Disease.

Pathways for Colonic Disease

GO Terms for Colonic Disease

Cellular components related to Colonic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 8.92 ESR1 PHOX2B STAT3 ZEB2

Biological processes related to Colonic Disease according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.96 ASCL1 EDNRB GDNF RET STAT3
2 positive regulation of cell proliferation GO:0008284 9.93 EDN3 EDNRB GDNF NOD2 STAT3
3 MAPK cascade GO:0000165 9.85 GDNF GFRA1 NRTN RET
4 axon guidance GO:0007411 9.81 GDNF GFRA1 NRTN RET
5 neuron differentiation GO:0030182 9.73 ASCL1 EDN3 PHOX2B RET
6 regulation of gene expression GO:0010468 9.72 ASCL1 EDN3 GDNF NOD2 PHOX2B
7 positive regulation of Notch signaling pathway GO:0045747 9.67 ASCL1 NOD2 STAT3
8 nervous system development GO:0007399 9.65 ACHE ASCL1 EDNRB GDNF GFRA1 KIDINS220
9 eating behavior GO:0042755 9.62 STAT3 UCHL1
10 peripheral nervous system development GO:0007422 9.62 EDNRB GDNF
11 oligodendrocyte development GO:0014003 9.61 ASCL1 SOX10
12 response to pain GO:0048265 9.6 EDNRB RET
13 melanocyte differentiation GO:0030318 9.59 EDN3 EDNRB
14 vasoconstriction GO:0042310 9.58 EDN3 EDNRB
15 glial cell differentiation GO:0010001 9.58 ASCL1 PHOX2B
16 developmental pigmentation GO:0048066 9.57 EDNRB ZEB2
17 sympathetic ganglion development GO:0061549 9.52 ASCL1 PHOX2B
18 vein smooth muscle contraction GO:0014826 9.46 EDN3 EDNRB
19 enteric nervous system development GO:0048484 9.46 EDNRB GDNF PHOX2B RET
20 sympathetic nervous system development GO:0048485 9.43 ASCL1 GDNF PHOX2B
21 noradrenergic neuron development GO:0003358 9.4 ASCL1 PHOX2B
22 posterior midgut development GO:0007497 9.37 EDNRB RET
23 neural crest cell migration GO:0001755 9.1 EDN3 EDNRB GDNF NRTN RET ZEB2
24 positive regulation of transcription by RNA polymerase II GO:0045944 10.02 ASCL1 ESR1 GDNF NOD2 PHOX2B STAT3
25 negative regulation of transcription by RNA polymerase II GO:0000122 10 ASCL1 EDNRB ESR1 STAT3 ZEB2

Molecular functions related to Colonic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.46 ASCL1 ESR1 PHOX2B STAT3
2 sequence-specific DNA binding GO:0043565 9.35 ASCL1 ESR1 PHOX2B STAT3 ZEB2
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.92 GDNF GFRA1 NRTN RET

Sources for Colonic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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