MCID: CLN006
MIFTS: 36

Colonic Pseudo-Obstruction

Categories: Gastrointestinal diseases

Aliases & Classifications for Colonic Pseudo-Obstruction

MalaCards integrated aliases for Colonic Pseudo-Obstruction:

Name: Colonic Pseudo-Obstruction 12 56 45 15 17 74
Primary Chronic Pseudo-Obstruction of Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3876
MeSH 45 D003112
SNOMED-CT 69 35065006
UMLS 74 C0009377

Summaries for Colonic Pseudo-Obstruction

MalaCards based summary : Colonic Pseudo-Obstruction, also known as primary chronic pseudo-obstruction of colon, is related to constipation and ogilvie syndrome. An important gene associated with Colonic Pseudo-Obstruction is ACHE (Acetylcholinesterase (Cartwright Blood Group)), and among its related pathways/superpathways are Synthesis of PC and Neurotransmitter Clearance In The Synaptic Cleft. The drugs Eluxadoline and Cola have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and heart, and related phenotypes are behavior/neurological and mortality/aging

Related Diseases for Colonic Pseudo-Obstruction

Diseases related to Colonic Pseudo-Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 constipation 29.6 HTR4 KIT MLN MLNR SST
2 ogilvie syndrome 11.9
3 butyrylcholinesterase deficiency 10.4 ACHE BCHE
4 hypoganglionosis 10.4 ACHE SYP
5 herpes zoster 10.3
6 malignant glandular tumor of peripheral nerve sheath 10.2 SST SYP
7 pancreatic somatostatinoma 10.2 SST SYP
8 gastrointestinal neuroendocrine tumor 10.2 SST SYP
9 myopathy, x-linked, with excessive autophagy 10.2 ACHE B2M
10 diffuse lipomatosis 10.2 BRD4 KANTR
11 pancreatic endocrine carcinoma 10.2 SST SYP
12 dementia, lewy body 10.2 ACHE BCHE SYP
13 diarrhea 10.2
14 intestinal volvulus 10.2
15 cutaneous ganglioneuroma 10.2 KIT SYP
16 pancreatoblastoma 10.2 SST SYP
17 carcinoid tumors, intestinal 10.2 SST SYP
18 mixed type thymoma 10.2 KIT SYP
19 meningeal melanomatosis 10.2 B2M SYP
20 endometrial small cell carcinoma 10.2 KIT SYP
21 laryngeal tuberculosis 10.2 CD59 KANTR
22 mediastinal cancer 10.2 KIT SYP
23 postencephalitic parkinson disease 10.2 KANTR SYP
24 adenoid basal cell carcinoma 10.2 B2M KIT
25 angiomyoma 10.2 KIT SYP
26 perivascular epithelioid cell tumor 10.2 KIT SYP
27 optic disk drusen 10.1 KANTR KCNMA1
28 meconium ileus 10.1
29 hypokalemia 10.1
30 anterior cranial fossa meningioma 10.1 KANTR SYP
31 pituitary-dependent cushing's disease 10.1 CD59 HTR4 SST
32 visual agnosia 10.1 KANTR SYP
33 agraphia 10.1 ACHE BCHE KANTR
34 binswanger's disease 10.1 ACHE SST SYP
35 inverted follicular keratosis 10.1 CALB2 HMBS
36 oculogyric crisis 10.1 B2M KANTR
37 abducens nerve disease 10.1 KANTR SYP
38 carcinoid syndrome 10.1 SST SYP
39 dental abscess 10.1 KANTR KIT
40 intraocular retinoblastoma 10.1 KANTR SYP
41 blind loop syndrome 10.1 HTR4 MLN
42 duodenogastric reflux 10.1 MLN SST
43 secretory diarrhea 10.1
44 megacolon 10.1
45 extragonadal seminoma 10.0 BRD4 KIT
46 venous hemangioma 10.0 CALB2 SYP
47 mucinous ovarian cystadenoma 10.0 CALB2 SYP
48 functional gastric disease 10.0 MLN MLNR SST
49 ovarian fibrothecoma 9.9 CALB2 KIT
50 merkel cell carcinoma 9.9 KIT SST SYP

Graphical network of the top 20 diseases related to Colonic Pseudo-Obstruction:



Diseases related to Colonic Pseudo-Obstruction

Symptoms & Phenotypes for Colonic Pseudo-Obstruction

MGI Mouse Phenotypes related to Colonic Pseudo-Obstruction:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.81 ACHE CALB2 GLA HMBS HTR4 KCNMA1
2 mortality/aging MP:0010768 9.65 ACHE B2M BCHE CD59 GLA HMBS
3 nervous system MP:0003631 9.32 ACHE B2M CALB2 GLA HMBS HTR4

Drugs & Therapeutics for Colonic Pseudo-Obstruction

Drugs for Colonic Pseudo-Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Eluxadoline Approved, Investigational Phase 3 864821-90-9
2 Cola Phase 3,Phase 2,Phase 1
3 Gastrointestinal Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Outcome of Palliative Management of Malignant Large Bowel Obstruction w/Colorectal Stents or Surgery Completed NCT00140868 Phase 3
2 Efficacy, Safety, and Tolerability of Eluxadoline in the Treatment of Participants With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d) Completed NCT01553747 Phase 3 Eluxadoline;Placebo
3 Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Irritable Bowel Syndrome With Diarrhea Completed NCT01130272 Phase 2 JNJ-27018966;Placebo
4 Therapeutic Oxygen for Gastrointestinal Atony (TOGA) Recruiting NCT03386136 Phase 1 100% Oxygen

Search NIH Clinical Center for Colonic Pseudo-Obstruction

Cochrane evidence based reviews: colonic pseudo-obstruction

Genetic Tests for Colonic Pseudo-Obstruction

Anatomical Context for Colonic Pseudo-Obstruction

MalaCards organs/tissues related to Colonic Pseudo-Obstruction:

42
Colon, Kidney, Heart, Testis, Brain, Lung, Thymus

Publications for Colonic Pseudo-Obstruction

Articles related to Colonic Pseudo-Obstruction:

(show top 50) (show all 221)
# Title Authors Year
1
Abdominal Wall Pseudohernia and Colonic Pseudo-obstruction as Complications of Herpes Zoster. ( 29723690 )
2019
2
Laparoscopic subtotal colectomy for a patient with chronic idiopathic colonic pseudo-obstruction: Report of a case. ( 30618177 )
2019
3
Colonic Pseudo-obstruction With Transition Zone: A Peculiar Eastern Severe Dysmotility. ( 30646485 )
2019
4
Idiopathic Dilatation of the Colon in a Nursing Home Resident, with a Suspected Acute Colonic Pseudo-Obstruction (Ogilvie Syndrome). ( 30700361 )
2019
5
Acute Colonic Pseudo-Obstruction Caused by Dexmedetomidine: A Case Report and Literature Review. ( 30826812 )
2019
6
Subcutaneous neostigmine appears safe and effective for acute colonic pseudo-obstruction (Ogilvie's syndrome). ( 31083785 )
2019
7
Clostridium ventriculi bacteremia following acute colonic pseudo-obstruction: a case report. ( 31103530 )
2019
8
Efficacy and Safety of Subcutaneous Neostigmine for Ileus, Acute Colonic Pseudo-obstruction, or Refractory Constipation. ( 29359574 )
2018
9
Fluoroscopy-guided trans-anal decompression tube placement in the treatment of acute colonic pseudo-obstruction: a single center experience. ( 29470625 )
2018
10
Chilaiditi's Sign Associated with Acute Colonic Pseudo-obstruction: A Radiological Diagnosis. ( 29796363 )
2018
11
Safety and Efficacy of Intermittent Bolus and Continuous Infusion Neostigmine for Acute Colonic Pseudo-Obstruction. ( 30373445 )
2018
12
Ogilvie's Syndrome or Colonic Pseudo-Obstruction. ( 30454296 )
2018
13
Helicobacter pylori prevalence and risk factors among children with celiac disease. ( 30541715 )
2018
14
Hypokalemia associated with acute colonic pseudo-obstruction in an ESRD patient. ( 28025959 )
2017
15
Acute colonic pseudo-obstruction associated with abdominal paracentesis. ( 28069781 )
2017
16
Ogilvie's Syndrome or Colonic Pseudo-Obstruction. ( 28228208 )
2017
17
Acute Colonic Pseudo-Obstruction with Feeding Intolerance in Critically Ill Patients: A Study according to Gut Wall Analysis. ( 28386273 )
2017
18
Postpartum Acute Colonic Pseudo-Obstruction (Ogilvie's Syndrome): A systematic review of case reports and case series. ( 28531835 )
2017
19
Secretory diarrhea and hypokalemia associated with colonic pseudo-obstruction: A case study and systematic analysis of the literature. ( 28580600 )
2017
20
An unusual manifestation of diabetic ketoacidosis and acute colonic pseudo-obstruction. ( 28620506 )
2017
21
Acute colonic pseudo-obstruction: A systematic review of aetiology and mechanisms. ( 28852322 )
2017
22
A Rare Cause of Acute Colonic Pseudo-obstruction: Ogilvie's Syndrome Caused by Herpes Zoster. ( 28992679 )
2017
23
Disseminated visceral varicella zoster virus presenting with the constellation of colonic pseudo-obstruction, acalculous cholecystitis and syndrome of inappropriate ADH secretion. ( 26899893 )
2016
24
Acute Colonic Pseudo-obstruction: Defining the Epidemiology, Treatment, and Adverse Outcomes of Ogilvie's Syndrome. ( 26874130 )
2016
25
Effective and Safe Use of Neostigmine in Treatment of Acute Kidney Injury Associated with Colonic Pseudo-obstruction after Cardiac Surgery. ( 26907487 )
2016
26
Use of neostigmine for acute colonic pseudo-obstruction in a patient receiving dexmedetomidine. ( 26947418 )
2016
27
Clinical Practice Guidelines for Colon Volvulus and Acute Colonic Pseudo-Obstruction. ( 27270510 )
2016
28
Acute colonic pseudo-obstruction (Ogilvie's syndrome) with caecal perforation after caesarean section. ( 27554827 )
2016
29
Acute colonic pseudo-obstruction caused by mycophenolate mofetil in a kidney transplant recipient. ( 24918432 )
2015
30
Images in clinical medicine. Acute colonic pseudo-obstruction. ( 25607448 )
2015
31
Giant colonic volvulus due to colonic pseudo-obstruction. ( 25716038 )
2015
32
Ogilvie's syndrome-acute colonic pseudo-obstruction. ( 25770746 )
2015
33
Acute colonic pseudo-obstruction in a child taking trihexyphenidyl for drooling: Prescribers beware. ( 25912627 )
2015
34
Acute colonic pseudo-obstruction in pregnancy. ( 26044983 )
2015
35
Hypokalemia Associated with Colonic Pseudo-Obstruction (Ogilvie's Syndrome). ( 26120577 )
2015
36
Acute Colonic Pseudo-Obstruction (Ogilvie's Syndrome) Following Total Laparoscopic Hysterectomy. ( 26164536 )
2015
37
Molecular and Cellular Characteristics of the Colonic Pseudo-obstruction in Patients With Intractable Constipation. ( 26424041 )
2015
38
Gastric-type extremely well-differentiated adenocarcinoma arising in the blind pouch of a bypassed stomach, presenting as colonic pseudo-obstruction. ( 26424554 )
2015
39
Hand-assisted laparoscopic subtotal colectomy with cecorectal anastomosis for chronic idiopathic colonic pseudo-obstruction: report of a case. ( 23203769 )
2014
40
Acute colonic pseudo-obstruction after hysterectomy in a patient with Friedreich ataxia. ( 24346123 )
2014
41
Recurrence of acute colonic pseudo-obstruction post-caesarean section: a case report. ( 24593760 )
2014
42
The clinical characteristics of colonic pseudo-obstruction and the factors associated with medical treatment response: a study based on a multicenter database in Korea. ( 24851028 )
2014
43
Intestinal neuronal dysplasia in a patient with chronic colonic pseudo-obstruction. ( 25091184 )
2014
44
Neostigmine for acute colonic pseudo-obstruction: A meta-analysis. ( 25568788 )
2014
45
Acute colonic pseudo-obstruction (Ogilvie syndrome) in progressive supranuclear palsy. ( 22902091 )
2013
46
Multiple successful emergent peristomal bowel resections under regional anesthesia in a patient with colonic pseudo-obstruction and severe chronic obstructive pulmonary disease. ( 23317608 )
2013
47
Neostigmine to relieve a suspected colonic pseudo-obstruction in a burn patient: a case-based review of the literature. ( 23359843 )
2013
48
The role of fentanyl in refractory opioid-related acute colonic pseudo-obstruction. ( 23369542 )
2013
49
Ogilvie's syndrome (acute colonic pseudo-obstruction) after caesarean section. ( 23552546 )
2013
50
Acute colonic pseudo-obstruction following allogeneic stem cell transplantation successfully treated by neostigmine. ( 23826585 )
2013

Variations for Colonic Pseudo-Obstruction

Expression for Colonic Pseudo-Obstruction

Search GEO for disease gene expression data for Colonic Pseudo-Obstruction.

Pathways for Colonic Pseudo-Obstruction

GO Terms for Colonic Pseudo-Obstruction

Biological processes related to Colonic Pseudo-Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to cadmium ion GO:0046686 8.62 B2M KIT

Molecular functions related to Colonic Pseudo-Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cholinesterase activity GO:0004104 8.96 ACHE BCHE
2 acetylcholinesterase activity GO:0003990 8.62 ACHE BCHE

Sources for Colonic Pseudo-Obstruction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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