MCID: CLN006
MIFTS: 30

Colonic Pseudo-Obstruction

Categories: Gastrointestinal diseases

Aliases & Classifications for Colonic Pseudo-Obstruction

MalaCards integrated aliases for Colonic Pseudo-Obstruction:

Name: Colonic Pseudo-Obstruction 12 54 44 15 17 71
Primary Chronic Pseudo-Obstruction of Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3876
MeSH 44 D003112
SNOMED-CT 67 35065006
UMLS 71 C0009377

Summaries for Colonic Pseudo-Obstruction

MalaCards based summary : Colonic Pseudo-Obstruction, also known as primary chronic pseudo-obstruction of colon, is related to intestinal obstruction and ileus. An important gene associated with Colonic Pseudo-Obstruction is ACHE (Acetylcholinesterase (Cartwright Blood Group)), and among its related pathways/superpathways are Synthesis of PC and Neurotransmitter Clearance In The Synaptic Cleft. The drugs Cola and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and smooth muscle.

Related Diseases for Colonic Pseudo-Obstruction

Diseases related to Colonic Pseudo-Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 intestinal obstruction 30.8 MLN ACHE
2 ileus 30.7 SST MLN
3 volvulus of midgut 30.5 SST MLNR MLN
4 constipation 30.3 SST MLNR MLN HTR4
5 diarrhea 30.1 SST MLN ACHE
6 intestinal pseudo-obstruction 30.1 SST MLNR MLN ACHE
7 irritable bowel syndrome 29.7 SST MLN HTR4
8 supranuclear palsy, progressive, 1 29.5 BCHE ACHE
9 ogilvie syndrome 11.5
10 megacolon 10.5
11 toxic megacolon 10.4
12 peritonitis 10.4
13 herpes zoster 10.4
14 hypokalemia 10.3
15 chickenpox 10.3
16 secretory diarrhea 10.2
17 toxic shock syndrome 10.2
18 intestinal perforation 10.2
19 amyloidosis 10.2
20 hypoganglionosis 10.2
21 neurogenic bowel 10.2 MLN ACHE
22 rumination disorder 10.1 MLNR MLN
23 pylorospasm 10.1 MLNR MLN
24 acute promyelocytic leukemia 10.1
25 graft-versus-host disease 10.1
26 leptin deficiency or dysfunction 10.1
27 respiratory failure 10.1
28 hellp syndrome 10.1
29 hypothyroidism 10.1
30 cerebral palsy 10.1
31 end stage renal disease 10.1
32 chronic kidney disease 10.1
33 chilaiditi syndrome 10.1
34 diabetic autonomic neuropathy 10.1 MLNR MLN
35 binswanger's disease 10.1 SST ACHE
36 butyrylcholinesterase deficiency 10.1 BCHE ACHE
37 persian gulf syndrome 10.1 BCHE ACHE
38 postgastrectomy syndrome 10.0 SST MLN
39 acute porphyria 10.0 MLN HMBS
40 duodenogastric reflux 10.0 SST MLN
41 dumping syndrome 10.0 SST MLN
42 hypertrophic pyloric stenosis 10.0 SST MLN
43 rem sleep behavior disorder 10.0 BCHE ACHE
44 pyloric stenosis 10.0 SST MLN
45 zollinger-ellison syndrome 10.0 SST MLN
46 transient refractive change 10.0 SST KCNMA1
47 amnestic disorder 10.0 BCHE ACHE
48 neuromuscular junction disease 10.0 BCHE ACHE
49 visceral myopathy 10.0
50 porphyria, acute intermittent 10.0

Graphical network of the top 20 diseases related to Colonic Pseudo-Obstruction:



Diseases related to Colonic Pseudo-Obstruction

Symptoms & Phenotypes for Colonic Pseudo-Obstruction

Drugs & Therapeutics for Colonic Pseudo-Obstruction

Drugs for Colonic Pseudo-Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola Phase 1
2
Bupivacaine Approved, Investigational 38396-39-3, 2180-92-9 2474
3 Pharmaceutical Solutions
4 Anesthetics, Local
5 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Therapeutic Oxygen for Gastrointestinal Atony (TOGA): Pilot Trial - Management of Acute Colonic Pseudo-Obstruction With Oxygen Supplementation Completed NCT03386136 Phase 1 100% Oxygen
2 Epidural Blockade for Ogilvie's Syndrome: A Prospective Pilot Study Not yet recruiting NCT04600427

Search NIH Clinical Center for Colonic Pseudo-Obstruction

Cochrane evidence based reviews: colonic pseudo-obstruction

Genetic Tests for Colonic Pseudo-Obstruction

Anatomical Context for Colonic Pseudo-Obstruction

MalaCards organs/tissues related to Colonic Pseudo-Obstruction:

40
Colon, Kidney, Smooth Muscle, Myeloid

Publications for Colonic Pseudo-Obstruction

Articles related to Colonic Pseudo-Obstruction:

(show top 50) (show all 426)
# Title Authors PMID Year
1
Acute colonic pseudo-obstruction: rapid correction with neostigmine in the emergency department. 61 54
18242923 2008
2
Incidence and Risk Factors for the Development of Acute Colonic Pseudo-Obstruction (Ogilvie Syndrome) in Total Joint Arthroplasty Patients. 61
32501855 2021
3
Use of a Heald anal stent to treat colonic pseudo-obstruction ('Ogilvie's syndrome'). 61
33590631 2021
4
Acute colonic pseudo-obstruction: a syndrome due to many causes. 61
31542890 2021
5
Inducible Deletion of YAP and TAZ in Adult Mouse Smooth Muscle Causes Rapid and Lethal Colonic Pseudo-Obstruction. 61
32992050 2021
6
Left Ventricular Compression and Hypotension Due to Acute Colonic Pseudo-Obstruction. 61
33424215 2020
7
Acute colonic pseudo-obstruction with bowel rupture after caesarean section in HELLP syndrome: a case report. 61
33238905 2020
8
Bowel dysfunction after elective spinal surgery: etiology, diagnostics and management based on the medical literature and experience in a university hospital. 61
33185695 2020
9
Acute Colonic Pseudo-Obstruction After Posterior Spinal Fusion: A Case Report and Literature Review. 61
32659357 2020
10
Successful surgical procedure based on careful preoperative imaging for chronic idiopathic colonic pseudo-obstruction: a case report. 61
33113019 2020
11
Safety and Efficacy of Intermittent Bolus and Continuous Infusion Neostigmine for Acute Colonic Pseudo-Obstruction. 61
30373445 2020
12
A case series of 3 patients with acute colonic pseudo-obstruction after vincristine administration. 61
33321026 2020
13
Acute colonic pseudo-obstruction after cesarean section and gastrointestinal symptoms⋆. 61
32721839 2020
14
Large-bowel obstruction: CT findings, pitfalls, tips and tricks. 61
32711335 2020
15
Acute colonic pseudo-obstruction causing Acute Respiratory Failure in Duchenne Muscular Dystrophy. 61
32475791 2020
16
Acute Colonic Pseudo-Obstruction After Ventriculoperitoneal Shunt Placement for Normal Pressure Hydrocephalus. 61
32601569 2020
17
Acute Colonic Pseudoobstruction (Ogilvie Syndrome) - A Severe Complication in the Evolution of the Hospitalized or Institutionalized Patients. 61
32614291 2020
18
Heparin-induced thrombocytopenia and acute colonic pseudo-obstruction after therapeutic anticoagulation in a very elderly patient with hip fracture: a case report. 61
32033561 2020
19
American Society for Gastrointestinal Endoscopy guideline on the role of endoscopy in the management of acute colonic pseudo-obstruction and colonic volvulus. 61
31791596 2020
20
Clozapine related Ogilvie syndrome with fatal outcome. 61
32051627 2020
21
Colonic Decompression Reduces Proximal Acute Colonic Pseudo-obstruction and Related Symptoms. 61
31567918 2020
22
Novel technique of insertion of decompression tube for Ogilvie's syndrome/colonic pseudo-obstruction. 61
31450262 2020
23
Ogilvie's Syndrome Presented as Angina: A Case Report. 61
32789121 2020
24
An overview of the efficacy and safety of prucalopride for the treatment of chronic idiopathic constipation. 61
31557072 2019
25
Laparoscopic subtotal colectomy for a patient with chronic idiopathic colonic pseudo-obstruction: Report of a case. 61
30618177 2019
26
Clostridium ventriculi bacteremia following acute colonic pseudo-obstruction: A case report. 61
31103530 2019
27
Acute Colonic Pseudo-Obstruction as a Manifestation of Lead Intoxication in a Conservator. 61
31737709 2019
28
Colonic pseudo-obstruction in a patient with Sheehan's syndrome. 61
31439564 2019
29
Acute colonic pseudoobstruction (Ogilvie's syndrome) in gynecologic and obstetric patients: case report and systematic review of the literature. 61
31093741 2019
30
Subcutaneous neostigmine appears safe and effective for acute colonic pseudo-obstruction (Ogilvie's syndrome). 61
31083785 2019
31
Acute colonic pseudo-obstruction in elderly Report of a case. 61
31112520 2019
32
Acute Colonic Pseudo-Obstruction Caused by Dexmedetomidine: A Case Report and Literature Review. 61
30826812 2019
33
Ogilvie syndrome in a 8 year old girl after laparoscopic appendectomy. 61
30894155 2019
34
Neostigmine treatment protocols applied in acute colonic pseudo-obstruction disease: A retrospective comparative study. 61
30541715 2019
35
Abdominal Wall Pseudohernia and Colonic Pseudo-obstruction as Complications of Herpes Zoster. 61
29723690 2019
36
Idiopathic Dilatation of the Colon in a Nursing Home Resident, with a Suspected Acute Colonic Pseudo-Obstruction (Ogilvie Syndrome). 61
30700361 2019
37
[Acute colonic pseudo-obstruction after caesarean section; Ogilvie's syndrome]. 61
30730690 2019
38
Percutaneous endoscopic cecostomy in the treatment of recurrent colonic pseudo-obstruction a case report of the first procedure in the Czech Republic. 61
31698914 2019
39
Colonic Pseudo-obstruction With Transition Zone: A Peculiar Eastern Severe Dysmotility. 61
30646485 2019
40
A Rare Presentation of Ogilvie's Syndrome. 61
31410359 2019
41
Perforated ileus after L5-S1 anterior lumbar interbody fusion: a case report presentation. 61
31463426 2019
42
Fluoroscopy-guided trans-anal decompression tube placement in the treatment of acute colonic pseudo-obstruction: a single center experience. 61
29470625 2018
43
Ogilvie's syndrome: management and outcomes. 61
29979381 2018
44
Intestinal pseudo-obstruction caused by herpes zoster: Case report and pathophysiology. 61
29988868 2018
45
Efficacy and Safety of Subcutaneous Neostigmine for Ileus, Acute Colonic Pseudo-obstruction, or Refractory Constipation. 61
29359574 2018
46
Chilaiditi's Sign Associated with Acute Colonic Pseudo-obstruction: A Radiological Diagnosis. 61
29796363 2018
47
Ogilvie's Syndrome or Colonic Pseudo-Obstruction. 61
30454296 2018
48
Ogilvie syndrome presenting with septic shock. 61
30325135 2018
49
Ogilvie's Syndrome after Robotic-Assisted Radical Hysterectomy for Cervical Cancer. 61
28711762 2018
50
Post-Pneumonectomy ARDS and Ogilvie Syndrome - A Case Report. 61
29967899 2018

Variations for Colonic Pseudo-Obstruction

Expression for Colonic Pseudo-Obstruction

Search GEO for disease gene expression data for Colonic Pseudo-Obstruction.

Pathways for Colonic Pseudo-Obstruction

Pathways related to Colonic Pseudo-Obstruction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.4 BCHE ACHE
2
Show member pathways
10.02 BCHE ACHE

GO Terms for Colonic Pseudo-Obstruction

Biological processes related to Colonic Pseudo-Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to nutrient GO:0007584 8.62 SST BCHE

Molecular functions related to Colonic Pseudo-Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carboxylic ester hydrolase activity GO:0052689 9.16 BCHE ACHE
2 cholinesterase activity GO:0004104 8.96 BCHE ACHE
3 acetylcholinesterase activity GO:0003990 8.62 BCHE ACHE

Sources for Colonic Pseudo-Obstruction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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