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MCID: CLN006
MIFTS: 32

Colonic Pseudo-Obstruction

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Colonic Pseudo-Obstruction

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MalaCards integrated aliases for Colonic Pseudo-Obstruction:

Name: Colonic Pseudo-Obstruction 12 54 43 15 17 71
Primary Chronic Pseudo-Obstruction of Colon 12

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3876
MeSH 43 D003112
SNOMED-CT 67 721680006
UMLS 71 C0009377
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Summaries for Colonic Pseudo-Obstruction

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MalaCards based summary : Colonic Pseudo-Obstruction, also known as primary chronic pseudo-obstruction of colon, is related to ileus and intestinal obstruction. An important gene associated with Colonic Pseudo-Obstruction is ACHE (Acetylcholinesterase (Cartwright Blood Group)), and among its related pathways/superpathways are Synthesis of PC and Neurotransmitter Clearance In The Synaptic Cleft. The drugs Eluxadoline and Phenobarbital have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and liver.

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Related Diseases for Colonic Pseudo-Obstruction

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Diseases related to Colonic Pseudo-Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 ileus 30.3 SST MLN
2 intestinal obstruction 30.2 SST MLNR MLN ACHE
3 constipation 30.1 SST MLNR MLN HTR4
4 diarrhea 29.9 SST MLN ACHE
5 ogilvie syndrome 12.0
6 megacolon 10.5
7 volvulus of midgut 10.4
8 toxic megacolon 10.4
9 herpes zoster 10.3
10 peritonitis 10.3
11 intestinal pseudo-obstruction 10.3
12 hypokalemia 10.3
13 neurogenic bowel 10.2 MLN ACHE
14 pylorospasm 10.2 MLNR MLN
15 chickenpox 10.2
16 diabetic autonomic neuropathy 10.2 MLNR MLN
17 butyrylcholinesterase deficiency 10.2 BCHE ACHE
18 secretory diarrhea 10.2
19 toxic shock syndrome 10.2
20 amyloidosis 10.2
21 hypoganglionosis 10.2
22 persian gulf syndrome 10.2 BCHE ACHE
23 rem sleep behavior disorder 10.1 BCHE ACHE
24 binswanger's disease 10.1 SST ACHE
25 acute promyelocytic leukemia 10.1
26 graft-versus-host disease 10.1
27 leptin deficiency or dysfunction 10.1
28 cardiac arrest 10.1
29 respiratory failure 10.1
30 guillain-barre syndrome 10.1
31 hypothyroidism 10.1
32 cerebral palsy 10.1
33 intestinal perforation 10.1
34 end stage renal disease 10.1
35 chilaiditi syndrome 10.1
36 postgastrectomy syndrome 10.1 SST MLN
37 amnestic disorder 10.1 BCHE ACHE
38 neuromuscular junction disease 10.0 BCHE ACHE
39 duodenogastric reflux 10.0 SST MLN
40 dumping syndrome 10.0 SST MLN
41 transient refractive change 10.0 SST KCNMA1
42 acute porphyria 10.0 MLN HMBS
43 hypertrophic pyloric stenosis 10.0 SST MLN
44 pyloric stenosis 10.0 SST MLN
45 zollinger-ellison syndrome 10.0 SST MLN
46 visceral myopathy 9.9
47 porphyria, acute intermittent 9.9
48 celiac disease 1 9.9
49 friedreich ataxia 9.9
50 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9

Graphical network of the top 20 diseases related to Colonic Pseudo-Obstruction:



Diseases related to Colonic Pseudo-Obstruction
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Symptoms & Phenotypes for Colonic Pseudo-Obstruction

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Drugs & Therapeutics for Colonic Pseudo-Obstruction

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Drugs for Colonic Pseudo-Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Eluxadoline Approved, Investigational Phase 3 864821-90-9
2
Phenobarbital Approved, Investigational Phase 3 50-06-6 4763
3 Cola Phase 3
4 Gastrointestinal Agents Phase 3
5 Hypnotics and Sedatives Phase 3
6 Excitatory Amino Acid Antagonists Phase 3
7 Neurotransmitter Agents Phase 3
8 GABA Modulators Phase 3
9 Anticonvulsants Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Patients With Diarrhea-Predominant Irritable Bowel Syndrome Completed NCT01553747 Phase 3 Eluxadoline;Placebo
2 Outcome of Palliative Management of Malignant Large Bowel Obstruction With Colorectal Stents or Surgery Completed NCT00140868 Phase 3
3 A Randomized, Double-blind, Placebo-controlled, Parallel Group, Dose Ranging, Multicenter Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Patients With Irritable Bowel Syndrome With Diarrhea Completed NCT01130272 Phase 2 Eluxadoline;Placebo
4 Therapeutic Oxygen for Gastrointestinal Atony (TOGA): Pilot Trial - Management of Acute Colonic Pseudo-Obstruction With Oxygen Supplementation Completed NCT03386136 Phase 1 100% Oxygen

Search NIH Clinical Center for Colonic Pseudo-Obstruction

Cochrane evidence based reviews: colonic pseudo-obstruction

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Genetic Tests for Colonic Pseudo-Obstruction

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Anatomical Context for Colonic Pseudo-Obstruction

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MalaCards organs/tissues related to Colonic Pseudo-Obstruction:

40
Colon, Kidney, Liver, Brain, Heart, Myeloid
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Publications for Colonic Pseudo-Obstruction

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Articles related to Colonic Pseudo-Obstruction:

(show top 50) (show all 414)
# Title Authors PMID Year
1
Acute colonic pseudo-obstruction: rapid correction with neostigmine in the emergency department. 54 61
18242923 2008
2
Incidence and Risk Factors for the Development of Acute Colonic Pseudo-Obstruction (Ogilvie Syndrome) in Total Joint Arthroplasty Patients. 61
32501855 2020
3
Acute colonic pseudo-obstruction causing Acute Respiratory Failure in Duchenne Muscular Dystrophy. 61
32475791 2020
4
American Society for Gastrointestinal Endoscopy guideline on the role of endoscopy in the management of acute colonic pseudo-obstruction and colonic volvulus. 61
31791596 2020
5
Heparin-induced thrombocytopenia and acute colonic pseudo-obstruction after therapeutic anticoagulation in a very elderly patient with hip fracture: a case report. 61
32033561 2020
6
Clozapine related Ogilvie syndrome with fatal outcome. 61
32051627 2020
7
Novel technique of insertion of decompression tube for Ogilvie's syndrome/colonic pseudo-obstruction. 61
31450262 2020
8
Colonic Decompression Reduces Proximal Acute Colonic Pseudo-obstruction and Related Symptoms. 61
31567918 2020
9
An overview of the efficacy and safety of prucalopride for the treatment of chronic idiopathic constipation. 61
31557072 2019
10
Laparoscopic subtotal colectomy for a patient with chronic idiopathic colonic pseudo-obstruction: Report of a case. 61
30618177 2019
11
Clostridium ventriculi bacteremia following acute colonic pseudo-obstruction: A case report. 61
31103530 2019
12
Acute colonic pseudo-obstruction: a syndrome due to many causes. 61
31542890 2019
13
Acute Colonic Pseudo-Obstruction as a Manifestation of Lead Intoxication in a Conservator. 61
31737709 2019
14
Colonic pseudo-obstruction in a patient with Sheehan's syndrome. 61
31439564 2019
15
Acute colonic pseudoobstruction (Ogilvie's syndrome) in gynecologic and obstetric patients: case report and systematic review of the literature. 61
31093741 2019
16
Subcutaneous neostigmine appears safe and effective for acute colonic pseudo-obstruction (Ogilvie's syndrome). 61
31083785 2019
17
Acute colonic pseudo-obstruction in elderly Report of a case. 61
31112520 2019
18
Acute Colonic Pseudo-Obstruction Caused by Dexmedetomidine: A Case Report and Literature Review. 61
30826812 2019
19
Abdominal Wall Pseudohernia and Colonic Pseudo-obstruction as Complications of Herpes Zoster. 61
29723690 2019
20
Neostigmine treatment protocols applied in acute colonic pseudo-obstruction disease: A retrospective comparative study. 61
30541715 2019
21
Ogilvie syndrome in a 8 year old girl after laparoscopic appendectomy. 61
30894155 2019
22
Idiopathic Dilatation of the Colon in a Nursing Home Resident, with a Suspected Acute Colonic Pseudo-Obstruction (Ogilvie Syndrome). 61
30700361 2019
23
[Acute colonic pseudo-obstruction after caesarean section; Ogilvie's syndrome]. 61
30730690 2019
24
Colonic Pseudo-obstruction With Transition Zone: A Peculiar Eastern Severe Dysmotility. 61
30646485 2019
25
A Rare Presentation of Ogilvie's Syndrome. 61
31410359 2019
26
Perforated ileus after L5-S1 anterior lumbar interbody fusion: a case report presentation. 61
31463426 2019
27
Percutaneous endoscopic cecostomy in the treatment of recurrent colonic pseudo-obstruction a case report of the first procedure in the Czech Republic. 61
31698914 2019
28
Fluoroscopy-guided trans-anal decompression tube placement in the treatment of acute colonic pseudo-obstruction: a single center experience. 61
29470625 2018
29
Safety and Efficacy of Intermittent Bolus and Continuous Infusion Neostigmine for Acute Colonic Pseudo-Obstruction. 61
30373445 2018
30
Ogilvie's syndrome: management and outcomes. 61
29979381 2018
31
Intestinal pseudo-obstruction caused by herpes zoster: Case report and pathophysiology. 61
29988868 2018
32
Efficacy and Safety of Subcutaneous Neostigmine for Ileus, Acute Colonic Pseudo-obstruction, or Refractory Constipation. 61
29359574 2018
33
Chilaiditi's Sign Associated with Acute Colonic Pseudo-obstruction: A Radiological Diagnosis. 61
29796363 2018
34
Ogilvie's Syndrome or Colonic Pseudo-Obstruction. 61
30454296 2018
35
Ogilvie syndrome presenting with septic shock. 61
30325135 2018
36
Ogilvie's Syndrome after Robotic-Assisted Radical Hysterectomy for Cervical Cancer. 61
28711762 2018
37
Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2). 61
29128300 2018
38
Post-Pneumonectomy ARDS and Ogilvie Syndrome - A Case Report. 61
29967899 2018
39
Secretory diarrhea and hypokalemia associated with colonic pseudo-obstruction: A case study and systematic analysis of the literature. 61
28580600 2017
40
Ogilvie's syndrome treated with an emergency laparotomy, right hemicolectomy and end ileostomy. 61
29018144 2017
41
A Rare Cause of Acute Colonic Pseudo-obstruction: Ogilvie's Syndrome Caused by Herpes Zoster. 61
28992679 2017
42
Acute colonic pseudo-obstruction: A systematic review of aetiology and mechanisms. 61
28852322 2017
43
Critically ill patients and gut motility: Are we addressing it? 61
28828195 2017
44
Colonoscopic decompression should be used before neostigmine in the treatment of Ogilvie's syndrome. 61
27432173 2017
45
Postpartum Acute Colonic Pseudo-Obstruction (Ogilvie's Syndrome): A systematic review of case reports and case series. 61
28531835 2017
46
A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction. 61
28439845 2017
47
An unusual manifestation of diabetic ketoacidosis and acute colonic pseudo-obstruction. 61
28620506 2017
48
Pharmacogenomics and tailored polypharmacy: an 80-year-old lady with rosuvastatin-associated rhabdomyolysis and maprotiline-related Ogilvie's syndrome
. 61
28257284 2017
49
An Alternative Approach to the Terminal Management of Ogilvie Syndrome. 61
28626383 2017
50
[Dysmorphic neonatal syndrome and Ogilvie syndrome]. 61
26769526 2017
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Variations for Colonic Pseudo-Obstruction

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Expression for Colonic Pseudo-Obstruction

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Search GEO for disease gene expression data for Colonic Pseudo-Obstruction.
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Pathways for Colonic Pseudo-Obstruction

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Pathways related to Colonic Pseudo-Obstruction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Synthesis of PC 65
10.4 BCHE ACHE
2
Neurotransmitter Clearance In The Synaptic Cleft 65
Show member pathways
 10.02 BCHE ACHE
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GO Terms for Colonic Pseudo-Obstruction

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Biological processes related to Colonic Pseudo-Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.02 SST MLNR MLN HTR4 CCL13

Molecular functions related to Colonic Pseudo-Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carboxylic ester hydrolase activity GO:0052689 9.16 BCHE ACHE
2 cholinesterase activity GO:0004104 8.96 BCHE ACHE
3 acetylcholinesterase activity GO:0003990 8.62 BCHE ACHE
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Sources for Colonic Pseudo-Obstruction

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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