MCID: CLN006
MIFTS: 36

Colonic Pseudo-Obstruction

Categories: Gastrointestinal diseases

Aliases & Classifications for Colonic Pseudo-Obstruction

MalaCards integrated aliases for Colonic Pseudo-Obstruction:

Name: Colonic Pseudo-Obstruction 12 55 44 15 73
Primary Chronic Pseudo-Obstruction of Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3876
MeSH 44 D003112
SNOMED-CT 68 35065006
UMLS 73 C0009377

Summaries for Colonic Pseudo-Obstruction

MalaCards based summary : Colonic Pseudo-Obstruction, also known as primary chronic pseudo-obstruction of colon, is related to constipation and ogilvie syndrome. An important gene associated with Colonic Pseudo-Obstruction is ACHE (Acetylcholinesterase (Cartwright Blood Group)), and among its related pathways/superpathways are Neurotransmitter Clearance In The Synaptic Cleft and Serotonin Receptor 4/6/7 and NR3C Signaling. The drugs Eluxadoline and Cola have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and heart, and related phenotypes are behavior/neurological and mortality/aging

Related Diseases for Colonic Pseudo-Obstruction

Diseases related to Colonic Pseudo-Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 constipation 29.8 HTR4 KIT MLN MLNR SST
2 ogilvie syndrome 11.8
3 herpes zoster 10.3
4 butyrylcholinesterase deficiency 10.3 ACHE BCHE
5 hyperglobulinemic purpura 10.2 BRD4 HSPG2
6 hypoganglionosis 10.2 ACHE SYP
7 amnestic disorder 10.2 ACHE BCHE HTR7
8 rumination disorder 10.2 ACHE HTR7 PTCRA
9 pancreatic serous cystadenoma 10.2 PTCRA SYP
10 diffuse lipomatosis 10.2 BRD4 KANTR
11 malignant glandular tumor of peripheral nerve sheath 10.1 SST SYP
12 adenoma of the pancreas 10.1 SST SYP
13 dementia, lewy body 10.1 ACHE BCHE SYP
14 pancreatic somatostatinoma 10.1 SST SYP
15 gastrointestinal neuroendocrine tumor 10.1 SST SYP
16 diarrhea 10.1
17 hypokalemia 10.1
18 pancreatic endocrine carcinoma 10.1 SST SYP
19 cutaneous ganglioneuroma 10.1 KIT SYP
20 mixed type thymoma 10.1 KIT SYP
21 endometrial small cell carcinoma 10.1 KIT SYP
22 solitary osseous plasmacytoma 10.1 B2M PTCRA
23 agraphia 10.1 ACHE BCHE KANTR
24 pancreatoblastoma 10.1 SST SYP
25 carcinoid tumors, intestinal 10.1 SST SYP
26 adenoid basal cell carcinoma 10.1 B2M KIT
27 pituitary-dependent cushing's disease 10.1 CD59 HTR4 SST
28 mediastinal cancer 10.1 KIT SYP
29 postencephalitic parkinson disease 10.1 KANTR SYP
30 binswanger's disease 10.1 ACHE SST SYP
31 angiomyoma 10.1 KIT SYP
32 perivascular epithelioid cell tumor 10.1 KIT SYP
33 inverted follicular keratosis 10.1 CALB2 HMBS
34 nervous system cancer 10.1 BCHE SST SYP
35 anterior cranial fossa meningioma 10.0 KANTR SYP
36 irritable bowel syndrome 10.0 HTR4 HTR7 MLN
37 secretory diarrhea 10.0
38 megacolon 10.0
39 meningeal melanomatosis 10.0 B2M SYP
40 dental abscess 10.0 KANTR KIT
41 prostate small cell carcinoma 10.0 KIT SYP
42 laryngeal tuberculosis 10.0 CD59 KANTR
43 visual agnosia 10.0 KANTR SYP
44 duodenogastric reflux 10.0 MLN SST
45 fallopian tube adenocarcinoma 10.0 CALB2 PTCRA
46 cerebellopontine angle tumor 10.0 KANTR PTCRA SYP
47 venous hemangioma 10.0 CALB2 SYP
48 oculogyric crisis 10.0 B2M KANTR
49 nervous system disease 10.0 ACHE BCHE KANTR SYP
50 ovarian fibrothecoma 10.0 CALB2 KIT

Graphical network of the top 20 diseases related to Colonic Pseudo-Obstruction:



Diseases related to Colonic Pseudo-Obstruction

Symptoms & Phenotypes for Colonic Pseudo-Obstruction

MGI Mouse Phenotypes related to Colonic Pseudo-Obstruction:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.85 ACHE CALB2 HMBS HSPG2 HTR4 HTR7
2 mortality/aging MP:0010768 9.7 ACHE B2M BCHE CD59 HMBS HSPG2
3 nervous system MP:0003631 9.36 ACHE B2M CALB2 HMBS HSPG2 HTR4

Drugs & Therapeutics for Colonic Pseudo-Obstruction

Drugs for Colonic Pseudo-Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Eluxadoline Approved, Investigational Phase 3 864821-90-9
2 Cola Phase 3,Phase 2,Phase 1
3 Gastrointestinal Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Outcome of Palliative Management of Malignant Large Bowel Obstruction w/Colorectal Stents or Surgery Completed NCT00140868 Phase 3
2 Efficacy, Safety, and Tolerability of Eluxadoline in the Treatment of Participants With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d) Completed NCT01553747 Phase 3 Eluxadoline;Placebo
3 Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Irritable Bowel Syndrome With Diarrhea Completed NCT01130272 Phase 2 JNJ-27018966;Placebo
4 Therapeutic Oxygen for Gastrointestinal Atony (TOGA) Recruiting NCT03386136 Phase 1 100% Oxygen

Search NIH Clinical Center for Colonic Pseudo-Obstruction

Cochrane evidence based reviews: colonic pseudo-obstruction

Genetic Tests for Colonic Pseudo-Obstruction

Anatomical Context for Colonic Pseudo-Obstruction

MalaCards organs/tissues related to Colonic Pseudo-Obstruction:

41
Colon, Kidney, Heart, Lung, Pancreas, Testis, Thymus

Publications for Colonic Pseudo-Obstruction

Articles related to Colonic Pseudo-Obstruction:

(show top 50) (show all 217)
# Title Authors Year
1
Fluoroscopy-guided trans-anal decompression tube placement in the treatment of acute colonic pseudo-obstruction: a single center experience. ( 29470625 )
2018
2
Efficacy and Safety of Subcutaneous Neostigmine for Ileus, Acute Colonic Pseudo-obstruction, or Refractory Constipation. ( 29359574 )
2018
3
Chilaiditi's Sign Associated with Acute Colonic Pseudo-obstruction: A Radiological Diagnosis. ( 29796363 )
2018
4
Ogilvie's Syndrome or Colonic Pseudo-Obstruction. ( 29642987 )
2018
5
Abdominal Wall Pseudohernia and Colonic Pseudo-obstruction as Complications of Herpes Zoster. ( 29723690 )
2018
6
Safety and Efficacy of Intermittent Bolus and Continuous Infusion Neostigmine for Acute Colonic Pseudo-Obstruction. ( 30373445 )
2018
7
Ogilvie's Syndrome or Colonic Pseudo-Obstruction. ( 30454296 )
2018
8
Neostigmine treatment protocols applied in acute colonic pseudo-obstruction disease: A retrospective comparative study. ( 30460898 )
2018
9
Ogilvie's Syndrome or Colonic Pseudo-Obstruction. ( 28228208 )
2017
10
Postpartum Acute Colonic Pseudo-Obstruction (Ogilvie's Syndrome): A systematic review of case reports and case series. ( 28531835 )
2017
11
Acute colonic pseudo-obstruction: A systematic review of aetiology and mechanisms. ( 28852322 )
2017
12
An unusual manifestation of diabetic ketoacidosis and acute colonic pseudo-obstruction. ( 28620506 )
2017
13
Acute colonic pseudo-obstruction associated with abdominal paracentesis. ( 28069781 )
2017
14
A Rare Cause of Acute Colonic Pseudo-obstruction: Ogilvie's Syndrome Caused by Herpes Zoster. ( 28992679 )
2017
15
Acute Colonic Pseudo-Obstruction with Feeding Intolerance in Critically Ill Patients: A Study according to Gut Wall Analysis. ( 28386273 )
2017
16
Secretory diarrhea and hypokalemia associated with colonic pseudo-obstruction: A case study and systematic analysis of the literature. ( 28580600 )
2017
17
Acute Colonic Pseudo-obstruction: Defining the Epidemiology, Treatment, and Adverse Outcomes of Ogilvie's Syndrome. ( 26874130 )
2016
18
Clinical Practice Guidelines for Colon Volvulus and Acute Colonic Pseudo-Obstruction. ( 27270510 )
2016
19
Disseminated visceral varicella zoster virus presenting with the constellation of colonic pseudo-obstruction, acalculous cholecystitis and syndrome of inappropriate ADH secretion. ( 26899893 )
2016
20
Use of neostigmine for acute colonic pseudo-obstruction in a patient receiving dexmedetomidine. ( 26947418 )
2016
21
Effective and Safe Use of Neostigmine in Treatment of Acute Kidney Injury Associated with Colonic Pseudo-obstruction after Cardiac Surgery. ( 26907487 )
2016
22
Hypokalemia associated with acute colonic pseudo-obstruction in an ESRD patient. ( 28025959 )
2016
23
Acute colonic pseudo-obstruction (Ogilvie's syndrome) with caecal perforation after caesarean section. ( 27554827 )
2016
24
Acute Colonic Pseudo-obstruction Caused by Acute Gastroenteritis: A Case Report. ( 27398711 )
2015
25
Images in clinical medicine. Acute colonic pseudo-obstruction. ( 25607448 )
2015
26
Molecular and Cellular Characteristics of the Colonic Pseudo-obstruction in Patients With Intractable Constipation. ( 26424041 )
2015
27
Giant colonic volvulus due to colonic pseudo-obstruction. ( 25716038 )
2015
28
Gastric-type extremely well-differentiated adenocarcinoma arising in the blind pouch of a bypassed stomach, presenting as colonic pseudo-obstruction. ( 26424554 )
2015
29
Hypokalemia Associated with Colonic Pseudo-Obstruction (Ogilvie's Syndrome). ( 26120577 )
2015
30
Ogilvie's syndrome-acute colonic pseudo-obstruction. ( 25770746 )
2015
31
Acute colonic pseudo-obstruction in a child taking trihexyphenidyl for drooling: Prescribers beware. ( 25912627 )
2015
32
Acute colonic pseudo-obstruction in pregnancy. ( 26044983 )
2015
33
Acute Colonic Pseudo-Obstruction (Ogilvie's Syndrome) Following Total Laparoscopic Hysterectomy. ( 26164536 )
2015
34
Recurrence of acute colonic pseudo-obstruction post-caesarean section: a case report. ( 24593760 )
2014
35
Intestinal neuronal displasia in a patient with chronic colonic pseudo-obstruction. ( 25091184 )
2014
36
The clinical characteristics of colonic pseudo-obstruction and the factors associated with medical treatment response: a study based on a multicenter database in Korea. ( 24851028 )
2014
37
Acute Colonic Pseudo-Obstruction Caused by Mycophenolate Mofetil in a Kidney Transplant Recipient. ( 24918432 )
2014
38
Neostigmine for acute colonic pseudo-obstruction: A meta-analysis. ( 25568788 )
2014
39
Multiple successful emergent peristomal bowel resections under regional anesthesia in a patient with colonic pseudo-obstruction and severe chronic obstructive pulmonary disease. ( 23317608 )
2013
40
Acute colonic pseudo-obstruction after hysterectomy in a patient with Friedreich ataxia. ( 24346123 )
2013
41
The role of fentanyl in refractory opioid-related acute colonic pseudo-obstruction. ( 23369542 )
2013
42
Acute colonic pseudo-obstruction following allogeneic stem cell transplantation successfully treated by neostigmine. ( 23826585 )
2013
43
Ogilvie's syndrome (acute colonic pseudo-obstruction) after caesarean section. ( 23552546 )
2013
44
Acute colonic pseudo-obstruction (Ogilvie syndrome) in progressive supranuclear palsy. ( 22902091 )
2013
45
Acute colonic pseudo-obstruction (Ogilvie's syndrome) mimicking pneumoperitoneum. ( 24190158 )
2013
46
Treatment of Acute Colonic Pseudo-Obstruction (Ogilvie's Syndrome). Systematic Review. ( 24281995 )
2013
47
Neostigmine to relieve a suspected colonic pseudo-obstruction in a burn patient: a case-based review of the literature. ( 23359843 )
2013
48
On colonoscopy in acute colonic pseudo obstruction. ( 23831185 )
2013
49
Acute colonic pseudo-obstruction (Ogilvie's syndrome) with myxedema coma and palmoplantar keratoderma. ( 24557975 )
2013
50
Advances and challenges in the management of acute colonic pseudo-obstruction (ogilvie syndrome). ( 23449274 )
2012

Variations for Colonic Pseudo-Obstruction

Expression for Colonic Pseudo-Obstruction

Search GEO for disease gene expression data for Colonic Pseudo-Obstruction.

Pathways for Colonic Pseudo-Obstruction

GO Terms for Colonic Pseudo-Obstruction

Cellular components related to Colonic Pseudo-Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 ACHE B2M BCHE CD59 HSPG2 KIT

Molecular functions related to Colonic Pseudo-Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cholinesterase activity GO:0004104 8.96 ACHE BCHE
2 acetylcholinesterase activity GO:0003990 8.62 ACHE BCHE

Sources for Colonic Pseudo-Obstruction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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