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MCID: CLN006
MIFTS: 36

Colonic Pseudo-Obstruction

Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Colonic Pseudo-Obstruction

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MalaCards integrated aliases for Colonic Pseudo-Obstruction:

Name: Colonic Pseudo-Obstruction 12 55 44 15 17 72
Primary Chronic Pseudo-Obstruction of Colon 12

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3876
MeSH 44 D003112
SNOMED-CT 68 35065006
UMLS 72 C0009377
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Summaries for Colonic Pseudo-Obstruction

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MalaCards based summary : Colonic Pseudo-Obstruction, also known as primary chronic pseudo-obstruction of colon, is related to hypoganglionosis and constipation. An important gene associated with Colonic Pseudo-Obstruction is ACHE (Acetylcholinesterase (Cartwright Blood Group)), and among its related pathways/superpathways are NF-kappaB Signaling and Regulation of KIT signaling. The drugs Eluxadoline and Phenobarbital have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and liver, and related phenotypes are behavior/neurological and homeostasis/metabolism

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Related Diseases for Colonic Pseudo-Obstruction

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Diseases related to Colonic Pseudo-Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
# Related Disease Score Top Affiliating Genes
1 hypoganglionosis 31.0 SYP ACHE
2 constipation 29.0 SST MLNR MLN KIT HTR4
3 ogilvie syndrome 12.0
4 butyrylcholinesterase deficiency 10.7 BCHE ACHE
5 hyperglobulinemic purpura 10.6 HSPG2 BRD4
6 megacolon 10.5
7 ileus 10.5
8 intestinal obstruction 10.4
9 inverted follicular keratosis 10.4 HMBS CALB2
10 toxic megacolon 10.4
11 intestinal volvulus 10.4
12 diarrhea 10.3
13 peritonitis 10.3
14 herpes zoster 10.3
15 dementia, lewy body 10.3 SYP BCHE ACHE
16 intestinal pseudo-obstruction 10.3
17 hypokalemia 10.3
18 malignant glandular tumor of peripheral nerve sheath 10.2 SYP SST
19 pancreatic somatostatinoma 10.2 SYP SST
20 gastrointestinal neuroendocrine tumor 10.2 SYP SST
21 chickenpox 10.2
22 nervous system disease 10.2 SYP BCHE ACHE
23 pancreatic endocrine carcinoma 10.2 SYP SST
24 secretory diarrhea 10.2
25 toxic shock syndrome 10.2
26 amyloidosis 10.2
27 pituitary-dependent cushing's disease 10.1 SST HTR4 CD59
28 cutaneous ganglioneuroma 10.1 SYP KIT
29 venous hemangioma 10.1 SYP CALB2
30 mixed type thymoma 10.1 SYP KIT
31 pancreatoblastoma 10.1 SYP SST
32 endometrial small cell carcinoma 10.1 SYP KIT
33 binswanger's disease 10.1 SYP SST ACHE
34 acute promyelocytic leukemia 10.1
35 graft-versus-host disease 10.1
36 leptin deficiency or dysfunction 10.1
37 cardiac arrest 10.1
38 guillain-barre syndrome 10.1
39 cerebral palsy 10.1
40 intestinal perforation 10.1
41 end stage renal failure 10.1
42 chilaiditi syndrome 10.1
43 chronic intestinal pseudoobstruction 10.1
44 ovarian fibrothecoma 10.1 KIT CALB2
45 adenoid basal cell carcinoma 10.0 KIT B2M
46 mediastinal cancer 10.0 SYP KIT
47 mucinous ovarian cystadenoma 10.0 SYP CALB2
48 ovarian melanoma 10.0 KIT CALB2
49 angiomyoma 10.0 SYP KIT
50 diffuse peritoneal leiomyomatosis 10.0 KIT CALB2

Graphical network of the top 20 diseases related to Colonic Pseudo-Obstruction:



Diseases related to Colonic Pseudo-Obstruction
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Symptoms & Phenotypes for Colonic Pseudo-Obstruction

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MGI Mouse Phenotypes related to Colonic Pseudo-Obstruction:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 ACHE CALB2 GLA HMBS HSPG2 HTR4
2 homeostasis/metabolism MP:0005376 10 ACHE B2M BCHE CD40LG CD59 GLA
3 mortality/aging MP:0010768 9.93 ACHE B2M BCHE CD40LG CD59 GLA
4 nervous system MP:0003631 9.73 ACHE B2M CALB2 CD40LG GLA HMBS
5 reproductive system MP:0005389 9.23 ACHE B2M BCHE CD40LG CD59 KCNMA1
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Drugs & Therapeutics for Colonic Pseudo-Obstruction

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Drugs for Colonic Pseudo-Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Eluxadoline Approved, Investigational Phase 3 864821-90-9
2
Phenobarbital Approved, Investigational Phase 3 50-06-6 4763
3 Cola Phase 3
4 Gastrointestinal Agents Phase 3
5 Neurotransmitter Agents Phase 3
6 GABA Agents Phase 3
7 Cytochrome P-450 Enzyme Inducers Phase 3
8 Hypnotics and Sedatives Phase 3
9 GABA Modulators Phase 3
10 Excitatory Amino Acid Antagonists Phase 3
11 Anticonvulsants Phase 3
12 Central Nervous System Depressants Phase 3
13 Excitatory Amino Acids Phase 3
14 Cytochrome P-450 CYP3A Inducers Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Patients With Diarrhea-Predominant Irritable Bowel Syndrome Completed NCT01553747 Phase 3 Eluxadoline;Placebo
2 Outcome of Palliative Management of Malignant Large Bowel Obstruction With Colorectal Stents or Surgery Completed NCT00140868 Phase 3
3 A Randomized, Double-blind, Placebo-controlled, Parallel Group, Dose Ranging, Multicenter Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Patients With Irritable Bowel Syndrome With Diarrhea Completed NCT01130272 Phase 2 JNJ-27018966;Placebo
4 Therapeutic Oxygen for Gastrointestinal Atony (TOGA): Pilot Trial - Management of Acute Colonic Pseudo-Obstruction With Oxygen Supplementation Recruiting NCT03386136 Phase 1 100% Oxygen

Search NIH Clinical Center for Colonic Pseudo-Obstruction

Cochrane evidence based reviews: colonic pseudo-obstruction

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Genetic Tests for Colonic Pseudo-Obstruction

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Anatomical Context for Colonic Pseudo-Obstruction

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MalaCards organs/tissues related to Colonic Pseudo-Obstruction:

41
Colon, Kidney, Liver, Brain, Heart, Myeloid
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Publications for Colonic Pseudo-Obstruction

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Articles related to Colonic Pseudo-Obstruction:

(show top 50) (show all 401)
# Title Authors PMID Year
1
Acute colonic pseudo-obstruction: rapid correction with neostigmine in the emergency department. 9 38
18242923 2008
2
Acute colonic pseudoobstruction (Ogilvie's syndrome) in gynecologic and obstetric patients: case report and systematic review of the literature. 38
31093741 2019
3
Subcutaneous neostigmine appears safe and effective for acute colonic pseudo-obstruction (Ogilvie's syndrome). 38
31083785 2019
4
Clostridium ventriculi bacteremia following acute colonic pseudo-obstruction: A case report. 38
31103530 2019
5
Acute colonic pseudo-obstruction in elderly Report of a case. 38
31112520 2019
6
Neostigmine treatment protocols applied in acute colonic pseudo-obstruction disease: A retrospective comparative study. 38
30541715 2019
7
Abdominal Wall Pseudohernia and Colonic Pseudo-obstruction as Complications of Herpes Zoster. 38
29723690 2019
8
Acute Colonic Pseudo-Obstruction Caused by Dexmedetomidine: A Case Report and Literature Review. 38
30826812 2019
9
Ogilvie syndrome in a 8 year old girl after laparoscopic appendectomy. 38
30894155 2019
10
Idiopathic Dilatation of the Colon in a Nursing Home Resident, with a Suspected Acute Colonic Pseudo-Obstruction (Ogilvie Syndrome). 38
30700361 2019
11
[Acute colonic pseudo-obstruction after caesarean section; Ogilvie's syndrome]. 38
30730690 2019
12
Colonic Pseudo-obstruction With Transition Zone: A Peculiar Eastern Severe Dysmotility. 38
30646485 2019
13
A Rare Presentation of Ogilvie's Syndrome. 38
31410359 2019
14
Laparoscopic subtotal colectomy for a patient with chronic idiopathic colonic pseudo-obstruction: Report of a case. 38
30618177 2019
15
Safety and Efficacy of Intermittent Bolus and Continuous Infusion Neostigmine for Acute Colonic Pseudo-Obstruction. 38
30373445 2018
16
Fluoroscopy-guided trans-anal decompression tube placement in the treatment of acute colonic pseudo-obstruction: a single center experience. 38
29470625 2018
17
Ogilvie's syndrome: management and outcomes. 38
29979381 2018
18
Intestinal pseudo-obstruction caused by herpes zoster: Case report and pathophysiology. 38
29988868 2018
19
Efficacy and Safety of Subcutaneous Neostigmine for Ileus, Acute Colonic Pseudo-obstruction, or Refractory Constipation. 38
29359574 2018
20
Chilaiditi's Sign Associated with Acute Colonic Pseudo-obstruction: A Radiological Diagnosis. 38
29796363 2018
21
Ogilvie syndrome presenting with septic shock. 38
30325135 2018
22
Ogilvie's Syndrome after Robotic-Assisted Radical Hysterectomy for Cervical Cancer. 38
28711762 2018
23
Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2). 38
29128300 2018
24
Ogilvie's Syndrome or Colonic Pseudo-Obstruction. 38
30454296 2018
25
Post-Pneumonectomy ARDS and Ogilvie Syndrome - A Case Report. 38
29967899 2018
26
Secretory diarrhea and hypokalemia associated with colonic pseudo-obstruction: A case study and systematic analysis of the literature. 38
28580600 2017
27
Ogilvie's syndrome treated with an emergency laparotomy, right hemicolectomy and end ileostomy. 38
29018144 2017
28
A Rare Cause of Acute Colonic Pseudo-obstruction: Ogilvie's Syndrome Caused by Herpes Zoster. 38
28992679 2017
29
Acute colonic pseudo-obstruction: A systematic review of aetiology and mechanisms. 38
28852322 2017
30
Critically ill patients and gut motility: Are we addressing it? 38
28828195 2017
31
Colonoscopic decompression should be used before neostigmine in the treatment of Ogilvie's syndrome. 38
27432173 2017
32
Postpartum Acute Colonic Pseudo-Obstruction (Ogilvie's Syndrome): A systematic review of case reports and case series. 38
28531835 2017
33
An unusual manifestation of diabetic ketoacidosis and acute colonic pseudo-obstruction. 38
28620506 2017
34
A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction. 38
28439845 2017
35
Pharmacogenomics and tailored polypharmacy: an 80-year-old lady with rosuvastatin-associated rhabdomyolysis and maprotiline-related Ogilvie's syndrome
. 38
28257284 2017
36
An Alternative Approach to the Terminal Management of Ogilvie Syndrome. 38
28626383 2017
37
[Dysmorphic neonatal syndrome and Ogilvie syndrome]. 38
26769526 2017
38
Hypokalemia associated with acute colonic pseudo-obstruction in an ESRD patient. 38
28025959 2017
39
Ogilvie's Syndrome or Colonic Pseudo-Obstruction. 38
28228208 2017
40
Acute colonic pseudo-obstruction associated with abdominal paracentesis. 38
28069781 2017
41
Acute Colonic Pseudo-Obstruction with Feeding Intolerance in Critically Ill Patients: A Study according to Gut Wall Analysis. 38
28386273 2017
42
Acute colonic pseudo-obstruction (Ogilvie's syndrome) with caecal perforation after caesarean section. 38
27554827 2016
43
Clinical Practice Guidelines for Colon Volvulus and Acute Colonic Pseudo-Obstruction. 38
27270510 2016
44
Gastrointestinal and liver infections in children undergoing antineoplastic chemotherapy in the years 2000. 38
27433098 2016
45
[Acute colonic pseudo-obstruction (Ogilvie syndrome) post-renal transplant]. 38
29421388 2016
46
Management of the lower gastrointestinal system in burn: A comprehensive review. 38
26774605 2016
47
Use of neostigmine for acute colonic pseudo-obstruction in a patient receiving dexmedetomidine. 38
26947418 2016
48
An obstruction not to forget: Pseudo-obstruction (Ogilvie syndrome): Single center experience. 38
27076728 2016
49
Effective and Safe Use of Neostigmine in Treatment of Acute Kidney Injury Associated with Colonic Pseudo-obstruction after Cardiac Surgery. 38
26907487 2016
50
Acute Colonic Pseudo-obstruction: Defining the Epidemiology, Treatment, and Adverse Outcomes of Ogilvie's Syndrome. 38
26874130 2016
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Variations for Colonic Pseudo-Obstruction

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Expression for Colonic Pseudo-Obstruction

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Search GEO for disease gene expression data for Colonic Pseudo-Obstruction.
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Pathways for Colonic Pseudo-Obstruction

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Pathways related to Colonic Pseudo-Obstruction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
NF-kappaB Signaling 4
11.77 LCK KIT CD40LG B2M
2
Regulation of KIT signaling 66
9.83 LCK KIT
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GO Terms for Colonic Pseudo-Obstruction

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Cellular components related to Colonic Pseudo-Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 SST KIT HSPG2 CD59 CD40LG BCHE
2 cell surface GO:0009986 9.55 KIT CD59 CD40LG B2M ACHE
3 extracellular region GO:0005576 9.28 SST MLN HSPG2 GLA CD59 CD40LG

Biological processes related to Colonic Pseudo-Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 8.92 SST LCK BCHE B2M

Molecular functions related to Colonic Pseudo-Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cholinesterase activity GO:0004104 8.96 BCHE ACHE
2 acetylcholinesterase activity GO:0003990 8.62 BCHE ACHE
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Sources for Colonic Pseudo-Obstruction

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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