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MCID: CLR009
MIFTS: 26

Color Agnosia

Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Color Agnosia

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MalaCards integrated aliases for Color Agnosia:

Name: Color Agnosia 12 15

Classifications:

MalaCards categories:
Anatomical: Mental diseases
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External Ids:

Disease Ontology 12 DOID:0060139
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Summaries for Color Agnosia

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Disease Ontology : 12 An agnosia that is a loss of the ability to recognize a color, while being able to perceive or distinguish it.

MalaCards based summary : Color Agnosia is related to mutism and alzheimer disease 8. An important gene associated with Color Agnosia is SLITRK1 (SLIT And NTRK Like Family Member 1), and among its related pathways/superpathways are Pathways of neurodegeneration - multiple diseases and Prion disease. Affiliated tissues include occipital lobe, and related phenotypes are behavior/neurological and cellular

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Related Diseases for Color Agnosia

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Diseases related to Color Agnosia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 mutism 10.3 GRN CNTNAP2
2 alzheimer disease 8 10.2 PARK7 LRRK2
3 echolalia 10.2 GRN CNTNAP2
4 agnosia 10.2
5 parkinson disease 6, autosomal recessive early-onset 10.2 PINK1 PARK7
6 impulse control disorder 10.2 SLITRK1 GRN
7 radial nerve lesion 10.2 PRKN LRRK2
8 parkinson disease 21 10.2 PRKN LRRK2
9 ophthalmomyiasis 10.1 PRKN LRRK2
10 meier-gorlin syndrome 2 10.1 PRKN CNTNAP2
11 epilepsy, idiopathic generalized 9 10.1 PRKN CNTNAP2
12 ulnar nerve lesion 10.1 PRKN LRRK2
13 postinfectious encephalitis 10.1 MBP CNTNAP2
14 miller fisher syndrome 10.1 CNTNAP2 AQP4
15 dystonia 12 10.0 PRKN PINK1 PARK7
16 acute retrobulbar neuritis 10.0 MBP AQP4
17 balo concentric sclerosis 10.0 MBP AQP4
18 autoimmune optic neuritis 10.0 MBP AQP4
19 ideomotor apraxia 10.0 SNCA GRN
20 internuclear ophthalmoplegia 10.0 MBP AQP4
21 obsessive-compulsive disorder 9.9 SLITRK1 GRN CNTNAP2
22 acute hemorrhagic leukoencephalitis 9.9 MBP AQP4
23 traumatic brain injury 9.9 MBP AQP4
24 brain injury 9.9 MBP AQP4
25 visual agnosia 9.9
26 posterior cortical atrophy 9.9
27 central pontine myelinolysis 9.9 MBP AQP4
28 juvenile-onset parkinson's disease 9.9 SNCA PRKN
29 parkinson disease 17 9.9 SNCA PARK7
30 combined oxidative phosphorylation deficiency 7 9.9 SNCA AQP4
31 acute disseminated encephalomyelitis 9.8 MBP CNTNAP2 AQP4
32 von economo's disease 9.8 SNCA LRRK2 CNTNAP2
33 aphasia 9.8 SNCA LRRK2 GRN
34 amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 9.8 SNCA PARK7 LRRK2
35 akinetic mutism 9.8 SNCA MBP
36 cranial nerve disease 9.8 PINK1 MBP AQP4
37 speech and communication disorders 9.8 SNCA GRN CNTNAP2
38 leber hereditary optic neuropathy, modifier of 9.8 PRKN PINK1 AQP4
39 parkinson disease 1, autosomal dominant 9.8 SNCA PRKN LRRK2
40 perry syndrome 9.8 SNCA GRN
41 tremor 9.7 SNCA PRKN LRRK2
42 essential tremor 9.7 SNCA PRKN LRRK2
43 communicating hydrocephalus 9.7 SNCA AQP4
44 cerebellar disease 9.7 SNCA PRKN PINK1
45 autoimmune disease of central nervous system 9.7 MBP CD19 AQP4
46 autoimmune disease of the nervous system 9.7 MBP CD19 AQP4
47 dystonia 9.6 PRKN PINK1 PARK7 LRRK2 GRN
48 parkinsonism 9.6 SNCA PINK1 PARK7 LRRK2
49 leukoencephalopathy, hereditary diffuse, with spheroids 9.6 SNCA PRKN MBP
50 postencephalitic parkinson disease 9.6 SNCA PRKN PARK7 LRRK2

Graphical network of the top 20 diseases related to Color Agnosia:



Diseases related to Color Agnosia
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Symptoms & Phenotypes for Color Agnosia

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MGI Mouse Phenotypes related to Color Agnosia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.29 AQP4 CD19 CNTNAP2 DAG1 ERBB4 GRN
2 cellular MP:0005384 10.2 CD19 CNTNAP2 DAG1 ERBB4 GRN LRRK2
3 growth/size/body region MP:0005378 10.17 AQP4 CD19 CNTNAP2 DAG1 GRN MBP
4 homeostasis/metabolism MP:0005376 10.14 AQP4 CD19 DAG1 GRN LRRK2 MBP
5 nervous system MP:0003631 10.07 AQP4 CD19 CNTNAP2 DAG1 ERBB4 GRN
6 mortality/aging MP:0010768 10.06 AQP4 CD19 DAG1 ERBB4 GRN LRRK2
7 integument MP:0010771 9.91 CD19 CNTNAP2 ERBB4 GRN LRRK2 PRKN
8 no phenotypic analysis MP:0003012 9.63 AQP4 GRN LRRK2 PINK1 PRKN SNCA
9 normal MP:0002873 9.5 CD19 DAG1 ERBB4 LRRK2 MBP PRKN
10 taste/olfaction MP:0005394 8.8 CNTNAP2 PINK1 SNCA
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Drugs & Therapeutics for Color Agnosia

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Search Clinical Trials , NIH Clinical Center for Color Agnosia

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Genetic Tests for Color Agnosia

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Anatomical Context for Color Agnosia

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MalaCards organs/tissues related to Color Agnosia:

40
Occipital Lobe
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Publications for Color Agnosia

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Articles related to Color Agnosia:

# Title Authors PMID Year
1
'I see colors when I touch them'. Color agnosia with visuo-tactile facilitation in a patient with posterior cortical atrophy. 61
32171092 2020
2
Curiouser and curiouser: genetic disorders of cortical specialization. 61
21296568 2011
3
[A patient with prosopagnosia which developed after an infarction in the left occipital lobe in addition to an old infarction in the right occipital lobe]. 61
21706834 2011
4
Unilateral paresthesia after isolated infarct of the splenium: case report. 61
20714962 2010
5
Intracranial venous thrombosis after placement of a lumbar drain. 61
19834826 2010
6
The cognitive profile of posterior cortical atrophy. 61
16476930 2006
7
Alexia without agraphia and associated disorders: importance of recognition in the rehabilitation setting. 61
3566519 1987
8
Optic aphasia, optic apraxia, and loss of dreaming. 61
2413956 1985
9
[Color agnosia: a brief review]. 61
920219 1977
10
[Visual agnosia for animate and inanimate objects; partial color agnosia after 2 consecutive vascular accidents in a 56 year old hypertensive]. 61
14398140 1955
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Variations for Color Agnosia

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Expression for Color Agnosia

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Search GEO for disease gene expression data for Color Agnosia.
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Pathways for Color Agnosia

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Pathways related to Color Agnosia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Pathways of neurodegeneration - multiple diseases 36
Show member pathways
 12.98 SNCA PRKN PINK1 PARK7 LRRK2 ERBB4
2
Prion disease 36
Show member pathways
 12.37 SNCA PRKN PINK1 PARK7 LRRK2
3
Chks in Checkpoint Regulation 63
Show member pathways
 12.28 SNCA PRKN PINK1 PARK7
4
Neuroscience 4
11.7 SNCA PRKN PINK1 PARK7 MBP LRRK2
5
Parkinsons Disease Pathway 1
11.28 SNCA PRKN PINK1 PARK7 LRRK2
6
Alpha-synuclein signaling 1
10.84 SNCA PRKN PARK7
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GO Terms for Color Agnosia

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Cellular components related to Color Agnosia according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.18 SNCA SLITRK1 PINK1 PARK7 MBP LRRK2
2 plasma membrane GO:0005886 10.13 SNCA SLITRK1 PARK7 MBP LRRK2 GRN
3 mitochondrion GO:0005739 10.02 SNCA PRKN PINK1 PARK7 LRRK2 ERBB4
4 cell junction GO:0030054 9.93 SNCA SLITRK1 LRRK2 DAG1 CNTNAP2
5 neuronal cell body GO:0043025 9.8 SNCA MBP LRRK2 CNTNAP2
6 mitochondrial matrix GO:0005759 9.78 SNCA PARK7 LRRK2 ERBB4
7 glutamatergic synapse GO:0098978 9.76 SLITRK1 LRRK2 ERBB4 DAG1
8 mitochondrial outer membrane GO:0005741 9.74 SNCA PINK1 LRRK2
9 presynapse GO:0098793 9.73 SNCA PRKN PARK7
10 growth cone GO:0030426 9.69 SNCA PINK1 LRRK2
11 membrane raft GO:0045121 9.62 PARK7 LRRK2 DAG1 CD19
12 mitochondrial intermembrane space GO:0005758 9.54 SNCA PINK1 PARK7
13 inclusion body GO:0016234 9.52 SNCA LRRK2
14 GABA-ergic synapse GO:0098982 9.43 SLITRK1 ERBB4 DAG1
15 axon GO:0030424 9.35 SNCA PINK1 PARK7 LRRK2 CNTNAP2
16 synapse GO:0045202 9.17 SNCA SLITRK1 PRKN PARK7 MBP LRRK2
17 Lewy body GO:0097413 9.16 PRKN PINK1

Biological processes related to Color Agnosia according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 10.01 SNCA PINK1 PARK7 ERBB4
2 protein stabilization GO:0050821 9.89 PRKN PINK1 PARK7 GRN
3 autophagy GO:0006914 9.87 PRKN PINK1 PARK7 LRRK2
4 positive regulation of protein kinase B signaling GO:0051897 9.86 PINK1 PARK7 ERBB4 CD19
5 response to oxidative stress GO:0006979 9.85 PRKN PINK1 LRRK2
6 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.82 SNCA PINK1 PARK7
7 cellular response to oxidative stress GO:0034599 9.78 SNCA PINK1 PARK7 LRRK2
8 adult locomotory behavior GO:0008344 9.76 SNCA PRKN PARK7
9 mitochondrion organization GO:0007005 9.76 PRKN PINK1 PARK7 LRRK2
10 regulation of canonical Wnt signaling pathway GO:0060828 9.72 PRKN LRRK2
11 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.71 ERBB4 CD19
12 regulation of presynapse assembly GO:1905606 9.71 SNCA SLITRK1
13 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.71 SNCA CD19
14 negative regulation of JNK cascade GO:0046329 9.71 PRKN PINK1
15 negative regulation of protein phosphorylation GO:0001933 9.71 SNCA PRKN PARK7 LRRK2
16 adult behavior GO:0030534 9.7 SLITRK1 CNTNAP2
17 regulation of dopamine secretion GO:0014059 9.7 SNCA PRKN
18 regulation of synapse organization GO:0050807 9.7 SLITRK1 DAG1
19 negative regulation of reactive oxygen species metabolic process GO:2000378 9.7 PRKN PINK1
20 regulation of neuron apoptotic process GO:0043523 9.69 PINK1 PARK7
21 regulation of neuron death GO:1901214 9.69 SNCA LRRK2
22 regulation of neurotransmitter secretion GO:0046928 9.69 SNCA PRKN
23 regulation of mitochondrial membrane potential GO:0051881 9.69 PRKN PINK1 PARK7
24 regulation of mitochondrion organization GO:0010821 9.68 PRKN PINK1
25 regulation of protein ubiquitination GO:0031396 9.68 PRKN PINK1
26 negative regulation of autophagosome assembly GO:1902902 9.68 PINK1 LRRK2
27 positive regulation of mitochondrial fission GO:0090141 9.68 PRKN PINK1
28 dopamine metabolic process GO:0042417 9.67 SNCA PRKN
29 cellular response to dopamine GO:1903351 9.67 PRKN LRRK2
30 regulation of reactive oxygen species metabolic process GO:2000377 9.67 SNCA PRKN PINK1
31 negative regulation of macroautophagy GO:0016242 9.66 PINK1 LRRK2
32 negative regulation of hydrogen peroxide-induced cell death GO:1903206 9.66 PARK7 LRRK2
33 negative regulation of oxidative stress-induced neuron death GO:1903204 9.65 PINK1 PARK7
34 striatum development GO:0021756 9.65 LRRK2 CNTNAP2
35 negative regulation of neuron apoptotic process GO:0043524 9.65 SNCA PRKN PINK1 PARK7 GRN
36 cellular response to manganese ion GO:0071287 9.64 PRKN LRRK2
37 regulation of cellular response to oxidative stress GO:1900407 9.64 PRKN PINK1
38 regulation of locomotion GO:0040012 9.63 SNCA LRRK2
39 positive regulation of autophagy of mitochondrion GO:1903599 9.63 PRKN PARK7
40 regulation of protein targeting to mitochondrion GO:1903214 9.62 PRKN PINK1
41 protein localization to mitochondrion GO:0070585 9.62 PRKN LRRK2
42 positive regulation of histone deacetylase activity GO:1901727 9.61 PINK1 LRRK2
43 positive regulation of mitophagy in response to mitochondrial depolarization GO:0098779 9.61 PRKN PINK1
44 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 9.61 PRKN PARK7 LRRK2
45 cellular response to toxic substance GO:0097237 9.6 PRKN PINK1
46 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway GO:1903377 9.58 PRKN PARK7
47 positive regulation of mitochondrial electron transport, NADH to ubiquinone GO:1902958 9.55 PINK1 PARK7
48 mitochondrion to lysosome transport GO:0099074 9.54 PRKN PINK1
49 synaptic transmission, dopaminergic GO:0001963 9.54 SNCA PRKN PARK7
50 negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway GO:1903384 9.52 PINK1 PARK7

Molecular functions related to Color Agnosia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.62 SNCA PRKN PARK7 CNTNAP2
2 actin binding GO:0003779 9.56 SNCA PRKN LRRK2 DAG1
3 ubiquitin-specific protease binding GO:1990381 9.37 PRKN PARK7
4 phospholipase binding GO:0043274 9.16 SNCA PRKN
5 cuprous ion binding GO:1903136 8.96 SNCA PARK7
6 tubulin binding GO:0015631 8.8 PRKN LRRK2 DAG1
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Sources for Color Agnosia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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