Aliases & Classifications for Color Blindness

MalaCards integrated aliases for Color Blindness:

Name: Color Blindness 12 76 55 43 15 73
Colour Vision Deficiency 12
Color Vision Defect 73
Colour Blindness 12
Blindness Color 12
Dyschromatopsia 73
Colorblindness 37

Classifications:



External Ids:

Disease Ontology 12 DOID:13399
ICD10 33 H53.5 H53.50
ICD9CM 35 368.5
MeSH 44 D003117
NCIt 50 C3891
KEGG 37 H00976

Summaries for Color Blindness

MedlinePlus : 43 Most of us see our world in color. We enjoy looking at a lush green lawn or a red rose in full bloom. If you have a color vision defect, you may see these colors differently than most people. There are three main kinds of color vision defects. Red-green color vision defects are the most common. This type occurs in men more than in women. The other major types are blue-yellow color vision defects and a complete absence of color vision. Most of the time, color blindness is genetic. There is no treatment, but most people adjust and the condition doesn't limit their activities.

MalaCards based summary : Color Blindness, also known as colour vision deficiency, is related to red-green color blindness and tritanopia, and has symptoms including photophobia, visual disturbance and other specified visual disturbances. An important gene associated with Color Blindness is OPN1SW (Opsin 1, Short Wave Sensitive), and among its related pathways/superpathways are Metabolism of fat-soluble vitamins and Visual Cycle in Retinal Rods. The drugs Ranibizumab and Dexlansoprazole have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 A blindness that is characterized by the inability or decreased ability to see color, or perceive color differences, under normal lighting conditions.

Wikipedia : 76 Color blindness, also known as color vision deficiency, is the decreased ability to see color or... more...

Related Diseases for Color Blindness

Diseases in the Color Blindness family:

Acquired Color Blindness

Diseases related to Color Blindness via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 red-green color blindness 33.6 CNGB3 OPN1LW OPN1MW
2 tritanopia 33.3 CNGB3 OPN1SW
3 color vision deficiency 33.2 CNGA3 OPN1LW OPN1MW
4 colorblindness, partial, protan series 32.6 CNGB3 OPN1LW OPN1MW
5 blue cone monochromacy 31.5 CNGA3 CNGB3 OPN1LW OPN1MW
6 achromatopsia 2 30.9 CNGA3 CNGB3 MFRP
7 achromatopsia 27.0 CNGA3 CNGB3 CNNM4 GNAT2 MFRP OPN1LW
8 acquired color blindness 12.2
9 colorblindness, partial, deutan series 11.1
10 hypogonadotropic hypogonadism 1 with or without anosmia 10.8
11 achromatopsia 7 10.8
12 retinitis pigmentosa 44 10.4 CNGA3 CNGB3
13 pathologic nystagmus 10.3 CNGA3 GNAT2
14 retinitis pigmentosa 26 10.2 CNGA3 CNGB3
15 stargardt disease 1 10.1 CNGB3 GNAT2
16 achromatopsia 4 10.0 CNGA3 CNGB3 GNAT2
17 achromatopsia 3 9.9 CNGA3 CNGB3 GNAT2
18 depression 9.8
19 cerebritis 9.7
20 night blindness 9.7
21 enhanced s-cone syndrome 9.7 CNGA3 MFRP
22 cone-rod dystrophy 2 9.6 CNGB3 CNNM4 GNAT2
23 multiple sclerosis 9.6
24 prostate cancer 9.6
25 hemophilia a 9.6
26 aging 9.6
27 amblyopia 9.6
28 prostatitis 9.6
29 hemoglobinopathy 9.6
30 retinitis 9.6
31 refractive error 9.6
32 muscular dystrophy 9.6
33 albinism 9.6
34 hemophilia 9.6
35 oligocone trichromacy 9.4 CNGA3 CNGB3 GNAT2 PDE6C
36 cone-rod dystrophy 6 9.4 CNGA3 CNGB3 GNAT2 PDE6C
37 myopia 9.1 MFRP OPN1LW OPN1MW
38 leber congenital amaurosis 8.8 CNGA3 CNGB3 MFRP
39 jalili syndrome 8.8 CNGA3 CNGB3 CNNM4 GNAT2 PDE6C
40 fundus dystrophy 8.4 CNGA3 CNGB3 CNNM4 GNAT2 MFRP
41 cone dystrophy 7.8 CNGB3 MFRP OPN1LW OPN1MW PDE6C PDE6H

Graphical network of the top 20 diseases related to Color Blindness:



Diseases related to Color Blindness

Symptoms & Phenotypes for Color Blindness

UMLS symptoms related to Color Blindness:


photophobia, visual disturbance, other specified visual disturbances, subjective visual disturbance, unspecified

GenomeRNAi Phenotypes related to Color Blindness according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.36 CNNM4
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.36 CNNM4 OPN1LW OPN1MW
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.36 OPN1LW
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.36 CNNM4
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.36 OPN1MW
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.36 OPN1MW
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-62 9.36 OPN1MW
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.36 OPN1LW
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.36 CNNM4

MGI Mouse Phenotypes related to Color Blindness:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.28 CNGA3 CNGB3 CNNM4 GNAT2 MFRP OPN1LW

Drugs & Therapeutics for Color Blindness

Drugs for Color Blindness (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4 347396-82-1 459903
2
Dexlansoprazole Approved, Investigational Phase 4 138530-94-6, 103577-45-3 9578005
3
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
4 Angiogenesis Inhibitors Phase 4
5 Angiogenesis Modulating Agents Phase 4
6 Antacids Phase 4
7 Anti-Ulcer Agents Phase 4
8 Gastrointestinal Agents Phase 4
9 Proton Pump Inhibitors Phase 4
10
Eplerenone Approved Phase 2, Phase 3 107724-20-9 150310 443872
11
Spironolactone Approved Phase 2, Phase 3 1952-01-7, 52-01-7 5833
12 diuretics Phase 2, Phase 3
13 Diuretics, Potassium Sparing Phase 2, Phase 3
14 Hormone Antagonists Phase 2, Phase 3
15 Hormones Phase 2, Phase 3
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
17 Mineralocorticoid Receptor Antagonists Phase 2, Phase 3
18 Mineralocorticoids Phase 2, Phase 3
19 Natriuretic Agents Phase 2, Phase 3
20
Clemastine Approved, Investigational Phase 1 15686-51-8 26987
21
Histamine Approved, Investigational Phase 1 75614-87-8, 51-45-6 774
22 Anti-Allergic Agents Phase 1
23 Antipruritics Phase 1
24 Dermatologic Agents Phase 1
25 Histamine Antagonists Phase 1
26 Histamine H1 Antagonists Phase 1
27
Histamine Phosphate Phase 1 51-74-1 65513
28 Neurotransmitter Agents Phase 1

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Evaluation of Changes in the Parameters of Optical Coherence Tomography After Intravitreal Injection of Lucentis Unknown status NCT01669447 Phase 4
2 Safety and Efficacy of Lansoprazole in Patients With Reflux Disease Completed NCT01135368 Phase 4 Lansoprazole
3 A Study of the Beneficial Effects of Eplerenone on Central Serous Chorioretinopathy Unknown status NCT02215330 Phase 2, Phase 3 Eplerenone;Maltodextrin
4 CNTF Implants for CNGB3 Achromatopsia Completed NCT01648452 Phase 1, Phase 2
5 Safety and Efficacy Trial of AAV Gene Therapy in Patients With CNGA3 Achromatopsia Recruiting NCT02935517 Phase 1, Phase 2
6 Long-Term Follow-Up Gene Therapy Study for Achromatopsia CNGB3 Recruiting NCT03278873 Phase 1, Phase 2
7 Gene Therapy for Achromatopsia (CNGB3) Recruiting NCT03001310 Phase 1, Phase 2
8 Safety and Efficacy Trial of AAV Gene Therapy in Patients With CNGB3 Achromatopsia Recruiting NCT02599922 Phase 1, Phase 2
9 Safety and Efficacy of a Single Subretinal Injection of rAAV.hCNGA3 in Patients With CNGA3-linked Achromatopsia Active, not recruiting NCT02610582 Phase 1, Phase 2 rAAV.hCNGA3
10 Effect of Clemastine Fumarate on Color Vision in Healthy Controls Completed NCT02613091 Phase 1 Clemastine fumarate
11 Incidence of Dyschromatopsia in Glaucoma Completed NCT02966678
12 Visual Activity Evoked by Infrared in Humans After Dark Adaptation Completed NCT02909985 Not Applicable
13 Clinical and Genetic Characterization of Individuals With Achromatopsia Completed NCT01846052
14 A Retrospective Chart Review of Patients Treated With Ocriplasmin for Symptomatic VMA Completed NCT02193945
15 Ì-SPIES, Comparison of Cystoscopy Images in Four Different SPIES Modalities Completed NCT02174302
16 Genetic Decryption of Leber Congenital Amaurosis (LCA) in a Large Cohort of Independent Families. Completed NCT02970266
17 Evaluating Color Perception Under LED Red/Green and Green Dominant Light Recruiting NCT01927536
18 Anthropogenetic Variability in the Group of Individuals With Febrile Seizures Recruiting NCT03481764
19 Evaluation of Different Color Vision Tests in Children Recruiting NCT02464241
20 Exploring Computerised Cognitive Training for People With Huntington's Disease Recruiting NCT02990676 Not Applicable
21 Inherited Retinal Degenerative Disease Registry Recruiting NCT02435940
22 Optic Neuritis and Ganglion Cell Layer Active, not recruiting NCT02864134
23 Prevalence of Dyschromatopsia in Glaucoma Patients Withdrawn NCT01994564

Search NIH Clinical Center for Color Blindness

Genetic Tests for Color Blindness

Anatomical Context for Color Blindness

MalaCards organs/tissues related to Color Blindness:

41
Testes, Eye, Liver, Retina, Prostate

Publications for Color Blindness

Articles related to Color Blindness:

(show top 50) (show all 193)
# Title Authors Year
1
Contact Lenses for Color Blindness. ( 29696828 )
2018
2
a8cGene Therapy for Color Blindness. ( 29259520 )
2017
3
Frequency of color blindness in pre-employment screening in a tertiary health care center in Pakistan. ( 28523050 )
2017
4
Protanopia (red color-blindness) in medaka: a simple system for producing color-blind fish and testing their spectral sensitivity. ( 28166717 )
2017
5
A review of color blindness for microscopists: guidelines and tools for accommodating and coping with color vision deficiency. ( 25739321 )
2015
6
A Cure for Color Blindness? Stand by Buck Rogers! ( 26421338 )
2015
7
Is adding a new class of cones to the retina sufficient to cure color-blindness? ( 26418498 )
2015
8
Why racial color-blindness is myopic. ( 24750092 )
2014
9
See no evil: Color blindness and perceptions of subtle racial discrimination in the workplace. ( 25111553 )
2014
10
Curing Color Blindness-Mice and Nonhuman Primates. ( 25147187 )
2014
11
Perceptions of racial confrontation: the role of color blindness and comment ambiguity. ( 23356360 )
2013
12
Color blindness among multiple sclerosis patients in Isfahan. ( 23267377 )
2012
13
Modern racism attitudes among white students: the role of dominance and authoritarianism and the mediating effects of racial color-blindness. ( 23057194 )
2012
14
Prevalence of refraction errors and color blindness in heavy vehicle drivers. ( 22553671 )
2011
15
Color blindness. ( 21774112 )
2011
16
More on color blindness. ( 22036741 )
2011
17
General principles in motion vision: color blindness of object motion depends on pattern velocity in honeybee and goldfish. ( 21518470 )
2011
18
Color blindness. ( 20885436 )
2010
19
Color blindness defect and medical laboratory technologists: unnoticed problems and the care for screening. ( 21137654 )
2010
20
Color blindness and military fitness for duty: a new look at old standards. ( 20180475 )
2010
21
Fuzzy-based simulation of real color blindness. ( 21096518 )
2010
22
The incidence of color blindness among some school children of Pokhara, Western Nepal. ( 20677611 )
2010
23
On the malleability of ideology: motivated construals of color blindness. ( 19309207 )
2009
24
Is multiculturalism or color blindness better for minorities? ( 19399972 )
2009
25
Gene therapy for color blindness. ( 20018970 )
2009
26
Congenital color blindness in young Turkish men. ( 17464858 )
2007
27
Visual acuity and X-linked color blindness. ( 16133025 )
2006
28
Color blindness and contrast perception in cuttlefish (Sepia officinalis) determined by a visual sensorimotor assay. ( 16376404 )
2006
29
Color blindness and interracial interaction: playing the political correctness game. ( 17176425 )
2006
30
Acquired color blindness in an elderly male patient from recurrent metastatic prostate cancer. ( 16108957 )
2005
31
Congenital color blindness in young Turkish men. ( 16019694 )
2005
32
More on color blindness. ( 15789477 )
2005
33
Statistical and molecular analyses of evolutionary significance of red-green color vision and color blindness in vertebrates. ( 15647522 )
2005
34
White privilege, color blindness, and services to battered women. ( 16043539 )
2005
35
Functional photoreceptor loss revealed with adaptive optics: an alternate cause of color blindness. ( 15148406 )
2004
36
Hypnotic color blindness and performance on the Stroop test. ( 11596828 )
2001
37
Color blindness and health care personnel. ( 11575992 )
2001
38
Impact of color blindness on recognition of blood in body fluids. ( 11176773 )
2001
39
Color-blindness in Calabria (Southern Italy): A north-south decreasing trend. ( 11534000 )
2000
40
Red laser pointers and color blindness. ( 10076196 )
1999
41
Re: Eagle Jr RC. Laser pointers and color blindness. Ophthalmology 1998; 105:760. ( 10076101 )
1999
42
Laser pointers and color blindness. ( 9593368 )
1998
43
Visual Pigments and Molecular Genetics of Color Blindness. ( 11390764 )
1998
44
Cortical color blindness is not &amp;quot;blindsight for color&amp;quot;. ( 9787052 )
1998
45
Laser pointers and color blindness. ( 9787345 )
1998
46
Complete sparing of high-contrast color input to motion perception in cortical color blindness. ( 10195150 )
1998
47
The chemistry of John Dalton's color blindness. ( 7863342 )
1995
48
A two-and-a-half color rainbow. Color blindness in physicians. ( 7980102 )
1994
49
Image segmentation of a color-blindness plate. ( 20941227 )
1994
50
Linkage of a normal personality trait to the color-blindness gene: preliminary evidence. ( 8274590 )
1993

Variations for Color Blindness

Copy number variations for Color Blindness from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 219466 7 127100000 129200000 Gain or loss OPN1SW Colorblindness

Expression for Color Blindness

Search GEO for disease gene expression data for Color Blindness.

Pathways for Color Blindness

GO Terms for Color Blindness

Cellular components related to Color Blindness according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 photoreceptor outer segment membrane GO:0042622 9.26 CNGA3 GNAT2
2 transmembrane transporter complex GO:1902495 9.16 CNGA3 CNGB3
3 photoreceptor disc membrane GO:0097381 9.13 OPN1LW OPN1MW OPN1SW
4 photoreceptor outer segment GO:0001750 9.02 CNGB3 GNAT2 OPN1LW OPN1MW OPN1SW

Biological processes related to Color Blindness according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 9.61 CNGA3 CNGB3 CNNM4 GNAT2 OPN1LW OPN1MW
2 retinoid metabolic process GO:0001523 9.58 OPN1LW OPN1MW OPN1SW
3 protein-chromophore linkage GO:0018298 9.54 OPN1LW OPN1MW OPN1SW
4 cellular response to light stimulus GO:0071482 9.5 OPN1LW OPN1MW OPN1SW
5 positive regulation of cytokinesis GO:0032467 9.48 OPN1LW OPN1MW
6 phototransduction GO:0007602 9.46 GNAT2 OPN1LW OPN1MW OPN1SW
7 retinal cone cell development GO:0046549 9.43 GNAT2 PDE6C
8 detection of visible light GO:0009584 9.43 OPN1LW OPN1MW OPN1SW
9 visual perception GO:0007601 9.32 CNGA3 CNGB3 CNNM4 GNAT2 MFRP OPN1LW
10 signal transduction GO:0007165 10 CNGA3 CNGB3 GNAT2 OPN1LW OPN1MW OPN1SW

Molecular functions related to Color Blindness according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 obsolete signal transducer activity GO:0004871 9.71 GNAT2 OPN1LW OPN1MW OPN1SW
2 3,5-cyclic-nucleotide phosphodiesterase activity GO:0004114 9.43 PDE6C PDE6H
3 3,5-cyclic-GMP phosphodiesterase activity GO:0047555 9.37 PDE6C PDE6H
4 photoreceptor activity GO:0009881 9.33 OPN1LW OPN1MW OPN1SW
5 intracellular cAMP activated cation channel activity GO:0005222 9.32 CNGA3 CNGB3
6 intracellular cGMP activated cation channel activity GO:0005223 9.26 CNGA3 CNGB3
7 cGMP binding GO:0030553 9.26 CNGA3 CNGB3 PDE6C PDE6H
8 G-protein coupled photoreceptor activity GO:0008020 8.92 GNAT2 OPN1LW OPN1MW OPN1SW

Sources for Color Blindness

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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