MCID: CLR108
MIFTS: 64

Colorectal Adenoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases

Aliases & Classifications for Colorectal Adenoma

MalaCards integrated aliases for Colorectal Adenoma:

Name: Colorectal Adenoma 39 12 30 6 15 17
Adenoma of Large Intestine 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050860
UMLS 74 C1302401

Summaries for Colorectal Adenoma

Disease Ontology : 12 An intestinal benign neoplasm that has material basis in epithelial tissue of glandular origin and is located in colon and located in rectum.

MalaCards based summary : Colorectal Adenoma, also known as adenoma of large intestine, is related to mutyh-associated polyposis and polyposis syndrome, hereditary mixed, 1. An important gene associated with Colorectal Adenoma is APC (APC Regulator Of WNT Signaling Pathway), and among its related pathways/superpathways are PI3K-Akt signaling pathway and TCR Signaling (Qiagen). The drugs Calcium Carbonate and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and testes, and related phenotypes are Increased shRNA abundance and homeostasis/metabolism

Wikipedia : 77 The colorectal adenoma is a benign glandular tumor of the colon and the rectum. It is a precursor lesion... more...

Related Diseases for Colorectal Adenoma

Diseases related to Colorectal Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 mutyh-associated polyposis 32.9 APC KRAS MUTYH TP53
2 polyposis syndrome, hereditary mixed, 1 32.6 APC MLH1 MUTYH PTGS2
3 mismatch repair cancer syndrome 32.4 APC CTNNB1 MLH1 MSH2
4 adenoma 30.6 APC CTNNB1 IGF1 KRAS MLH1 MSH2
5 adenocarcinoma 30.4 APC CTNNB1 HRAS KRAS MLH1 PTGS2
6 familial adenomatous polyposis 1 30.3 APC CTNNB1
7 homocysteinemia 30.1 CRP MTHFR MTR
8 familial adenomatous polyposis 29.8 APC CTNNB1 KRAS MLH1 MSH2 MUTYH
9 ulcerative colitis 29.7 CRP CTNNB1 MLH1 MSH2
10 familial colorectal cancer 29.7 APC MLH1 MSH2 MUTYH TP53
11 lynch syndrome 29.6 APC CTNNB1 KRAS MGMT MLH1 MSH2
12 cervical cancer 29.4 CTNNB1 HRAS IGFBP3 PTGS2 TP53
13 prostate cancer 28.9 CTNNB1 HRAS IGF1 IGFBP3 KRAS PTGS2
14 gastric cancer 28.7 APC CTNNB1 KRAS MGMT MLH1 MSH2
15 endometrial cancer 28.5 CTNNB1 HRAS IGF1 KRAS MLH1 MSH2
16 breast cancer 28.0 APC CTNNB1 HRAS IGF1 IGFBP3 KRAS
17 colorectal cancer 27.8 APC CTNNB1 HRAS IGF1 IGFBP3 KRAS
18 large intestine cancer 26.6 APC CRP CTNNB1 HRAS IGF1 IGFBP3
19 familial adenomatous polyposis 2 11.8
20 colorectal cancer 12 11.7
21 colorectal cancer 1 11.4
22 desmoid disease, hereditary 10.5 APC CTNNB1
23 leukorrhea 10.4 CRP PTGS2
24 adult hepatocellular carcinoma 10.4 CTNNB1 TP53
25 rare adenocarcinoma of the breast 10.4 KRAS TP53
26 juvenile polyposis syndrome 10.4 APC MUTYH PTGS2
27 homocystinuria due to deficiency of n -methylenetetrahydrofolate reductase activity 10.4 MTHFR MTR
28 protoplasmic astrocytoma 10.4 PTGS2 TP53
29 barrett's adenocarcinoma 10.4 KRAS PTGS2 TP53
30 colonic benign neoplasm 10.4 CTNNB1 KRAS PTGS2
31 colon adenoma 10.4 APC KRAS VDR
32 anal squamous cell carcinoma 10.3 APC MLH1 TP53
33 peutz-jeghers syndrome 10.3 APC CTNNB1 TP53
34 ureteral obstruction 10.3 CTNNB1 PTGS2 TP53
35 hyperplastic polyposis syndrome 10.3 APC KRAS MUTYH TP53
36 mesenteric vascular occlusion 10.3 MTHFR ODC1
37 intrahepatic cholangiocarcinoma 10.3 CTNNB1 KRAS TP53
38 helicobacter pylori infection 10.3
39 hepatoblastoma 10.3 APC CTNNB1 TP53
40 slipped capital femoral epiphysis 10.3 IGF1 IGFBP3
41 diabetes mellitus, noninsulin-dependent 10.3
42 appendix carcinoid tumor 10.3 MLH1 MSH2
43 attenuated familial adenomatous polyposis 10.3 APC MSH2 MUTYH
44 colorectal cancer, hereditary nonpolyposis, type 7 10.2 MLH1 MSH2
45 adenosquamous colon carcinoma 10.2 MLH1 MSH2
46 body mass index quantitative trait locus 1 10.2
47 fatty liver disease 10.2
48 stomach disease 10.2 CTNNB1 MLH1 PTGS2 TP53
49 sigmoid neoplasm 10.2 HRAS KRAS
50 secondary adrenal insufficiency 10.2 IGF1 IGFBP3

Graphical network of the top 20 diseases related to Colorectal Adenoma:



Diseases related to Colorectal Adenoma

Symptoms & Phenotypes for Colorectal Adenoma

GenomeRNAi Phenotypes related to Colorectal Adenoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 9.02 APC MLH1 MTHFR MTR MUTYH

MGI Mouse Phenotypes related to Colorectal Adenoma:

47 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.51 APC CRP CTNNB1 EPHX1 HRAS IGF1
2 mortality/aging MP:0010768 10.41 APC CTNNB1 HRAS IGF1 KRAS MGMT
3 cellular MP:0005384 10.33 APC CTNNB1 IGF1 KRAS MLH1 MSH2
4 integument MP:0010771 10.33 APC CTNNB1 HRAS IGF1 IGFBP3 KRAS
5 endocrine/exocrine gland MP:0005379 10.32 APC CTNNB1 HRAS IGF1 IGFBP3 KRAS
6 neoplasm MP:0002006 10.26 APC CTNNB1 EPHX1 HRAS IGF1 KRAS
7 cardiovascular system MP:0005385 10.25 APC CRP CTNNB1 HRAS IGF1 KRAS
8 digestive/alimentary MP:0005381 10.24 APC CTNNB1 HRAS KRAS MLH1 MSH2
9 nervous system MP:0003631 10.23 APC CTNNB1 HRAS IGF1 KRAS MSH2
10 limbs/digits/tail MP:0005371 10.14 APC CTNNB1 IGF1 IGFBP3 KRAS MTHFR
11 muscle MP:0005369 10.1 APC CTNNB1 IGF1 IGFBP3 KRAS PTGS2
12 liver/biliary system MP:0005370 10.07 APC CTNNB1 IGFBP3 KRAS MTHFR PTGS2
13 normal MP:0002873 10.06 APC CTNNB1 HRAS IGF1 KRAS NAT1
14 hearing/vestibular/ear MP:0005377 10.04 APC CTNNB1 IGF1 KRAS TP53 VDR
15 no phenotypic analysis MP:0003012 9.98 CTNNB1 HRAS KRAS MGMT MTHFR PTGS2
16 reproductive system MP:0005389 9.96 APC CTNNB1 IGF1 KRAS MLH1 MTHFR
17 renal/urinary system MP:0005367 9.92 APC CTNNB1 HRAS IGF1 KRAS PTGS2
18 pigmentation MP:0001186 9.77 APC CTNNB1 IGFBP3 KRAS TP53
19 respiratory system MP:0005388 9.76 CTNNB1 HRAS IGF1 KRAS MGMT MLH1
20 skeleton MP:0005390 9.65 APC CTNNB1 HRAS IGF1 IGFBP3 KRAS
21 vision/eye MP:0005391 9.23 APC CTNNB1 KRAS MLH1 MTHFR NAT1

Drugs & Therapeutics for Colorectal Adenoma

Drugs for Colorectal Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 105)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium Carbonate Approved, Investigational Phase 2, Phase 3,Phase 3 471-34-1
2
leucovorin Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 58-05-9 143 6006
3
Aspirin Approved, Vet_approved Phase 3,Phase 2,Not Applicable 50-78-2 2244
4
Celecoxib Approved, Investigational Phase 3,Phase 2 169590-42-5 2662
5
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
6
Tocopherol Approved, Investigational Phase 3 1406-66-2 14986
7
Zinc Approved, Investigational Phase 3 7440-66-6 32051
8
Ergocalciferol Approved, Nutraceutical Phase 2, Phase 3,Phase 3,Phase 1 50-14-6 5280793
9
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1 1406-16-2
10
Vitamin D3 Approved, Nutraceutical Phase 2, Phase 3,Phase 3,Phase 1 67-97-0 5280795 6221
11
Calcium Approved, Nutraceutical Phase 2, Phase 3,Phase 3,Phase 1 7440-70-2 271
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 59-30-3 6037
13
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
14
Calcitriol Approved, Nutraceutical Phase 3,Phase 1 32222-06-3 5280453 134070
15
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 68-26-8, 22737-96-8, 11103-57-4 9904001 445354
16
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 54670067 5785
17 Tocotrienol Investigational Phase 3 6829-55-6
18 Calciferol Phase 2, Phase 3,Phase 3,Phase 1
19 Bone Density Conservation Agents Phase 2, Phase 3,Phase 3,Phase 1
20 Ergocalciferols Phase 2, Phase 3,Phase 3,Phase 1
21 Vitamin D2 Phase 2, Phase 3,Phase 3,Phase 1
22 Hormones Phase 2, Phase 3,Phase 3,Phase 1
23 Nutrients Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
24 Trace Elements Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
25 Vitamins Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
26 Micronutrients Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
27 Calcium, Dietary Phase 2, Phase 3,Phase 3,Phase 1
28 Folate Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
29 Vitamin B9 Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
30 Vitamin B Complex Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
31 Hematinics Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
32 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
33 Peripheral Nervous System Agents Phase 3,Phase 2,Not Applicable
34 Cyclooxygenase Inhibitors Phase 3,Phase 2,Not Applicable
35 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 2,Not Applicable
36 Analgesics Phase 3,Phase 2,Not Applicable
37 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
38 Analgesics, Non-Narcotic Phase 3,Phase 2,Not Applicable
39 Platelet Aggregation Inhibitors Phase 3,Phase 2,Not Applicable
40 Antipyretics Phase 3,Phase 2,Not Applicable
41 Fibrinolytic Agents Phase 3,Phase 2,Not Applicable
42 Cola Phase 3,Phase 2,Phase 1,Not Applicable
43 Cyclooxygenase 2 Inhibitors Phase 3,Phase 2
44 Anti-Ulcer Agents Phase 2, Phase 3,Phase 3
45 Antacids Phase 2, Phase 3,Phase 3
46 Gastrointestinal Agents Phase 2, Phase 3,Phase 3
47 Antioxidants Phase 3,Phase 2
48 Tocopherols Phase 3
49 Tocotrienols Phase 3
50 Protective Agents Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 125)
# Name Status NCT ID Phase Drugs
1 Efficacy Combined Fecal Immunochemical Test-Sigmoidoscopy for the Detection of Advanced Colorectal Neoplasia Unknown status NCT01767870 Phase 4
2 Study of Calcium Plus Vitamin D Supplementation in Prevention of Colorectal Adenomas Recurrence Unknown status NCT02143505 Phase 2, Phase 3 Ca plus vit D
3 Study of Folic Acid, Calcium and Vitamin D in Preventing Colorectal Polyps and Colorectal Cancer Unknown status NCT02066688 Phase 2, Phase 3 folic acid;folic acid calcium vitamin D3;calcium
4 Study of Berberine Hydrochloride in Prevention of Colorectal Adenomas Recurrence Completed NCT02226185 Phase 2, Phase 3 Berberine hydrochloride;placebo
5 A Study to Evaluate the Effect of MK0966 (Rofecoxib) on the Recurrence of Colorectal Adenomas (0966-122) Completed NCT00282386 Phase 3 MK0966; Rofecoxib / Duration of Treatment: 156 weeks;Placebo/ Duration of Treatment: 156 weeks
6 Prevention of Colorectal Sporadic Adenomatous Polyps (PRESAP) Completed NCT00141193 Phase 3 Celecoxib
7 Celecoxib to Prevent Colorectal Cancer in Patients Who Have Undergone Surgery to Remove Polyps Completed NCT00005094 Phase 3 celecoxib
8 Aspirin in Treating Patients With Colorectal Cancer That Has Been Surgically Removed Completed NCT00002527 Phase 3 aspirin
9 Vitamin D/Calcium Polyp Prevention Study Completed NCT00153816 Phase 2, Phase 3 Calcium Carbonate;Vitamin D3;placebo
10 Aspirin/Folate Prevention of Large Bowel Polyps Completed NCT00272324 Phase 2, Phase 3 Aspirin;Folate
11 S0000D: Effect of Vitamin E and/or Selenium on Colorectal Polyps in Men Enrolled on SELECT Trial SWOG-S0000 Completed NCT00706121 Phase 3 Vitamin E;Selenium;Vitamin E placebo;selenium placebo
12 A Research of Berberine Hydrochloride to Prevent Colorectal Adenomas in Patients With Previous Colorectal Cancer Recruiting NCT03281096 Phase 2, Phase 3 Berberine hydrochloride;Placebo
13 Effect of Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch Syndrome Recruiting NCT02813824 Phase 3 Acetylsalicylic acid lysinate 300 mg;Placebo (for Aspirin 300);Acetylsalicylic acid lysinate 100 mg;Placebo 100 (for Aspirin 100)
14 Primary Chemoprevention of Familial Adenomatous Polyposis With Berberine Hydrochloride Recruiting NCT03333265 Phase 2, Phase 3 100mg Berberine hydrochloride;300mg Berberine hydrochloride;Placebo Oral Tablet
15 Aspirin for Prevention of Postsurgical Recurrence and Metastasis in Asian Colorectal Cancer Patients: a Multi-center Randomized Trial Recruiting NCT02607072 Phase 3 Acetylsalicylic acid (ASA)/aspirin 200 mg daily;Acetylsalicylic acid (ASA)/aspirin 100 mg daily;Placebo
16 Vitamin D and Omega-3 Trial (VITAL) Active, not recruiting NCT01169259 Phase 3 omega-3 fatty acids (fish oil)
17 Chemoprevention of Colorectal Adenomas Terminated NCT00486512 Phase 3 aspirin, 1,25-dihydroxycholecalciferol, calcium;placebo
18 Antioxidant Supplement and Reduction of Metachronous Adenomas of the Large Bowel: a Double Blind Randomized Trial Terminated NCT01437826 Phase 3 antioxidants;placebo
19 APACC Study:Prospective Study on Aspirin Efficacy in Reducing Colorectal Adenoma Recurrence Terminated NCT00224679 Phase 3 Aspirin
20 Selenium for Prevention of Adenomatous Colorectal Polyps Terminated NCT00078897 Phase 3 Selenium
21 Rosuvastatin in Treating Patients With Stage I or Stage II Colon Cancer That Was Removed By Surgery Terminated NCT01011478 Phase 3 rosuvastatin
22 Minimizing the Risk of Metachronous Adenomas of the Colorectum With Green Tea Extract -MIRACLE- Unknown status NCT01360320 Phase 2
23 Mesalazine Effects in Sporadic Colorectal Adenoma Patients Completed NCT01894685 Phase 2 Mesalazine;Placebo
24 Evaluation of Surgically Resected Colorectal Adenomas and Carcinomas After 7 Days Pretreatment With Celecoxib Completed NCT00582660 Phase 2 Celecoxib;Placebo
25 Trial of Metformin for Colorectal Cancer Risk Reduction for History of Colorectal Adenomas and Elevated BMI Completed NCT01312467 Phase 2 metformin hydrochloride
26 Study of the MUC1 Peptide-Poly-ICLC Adjuvant Vaccine in Individuals With Advanced Colorectal Adenoma Completed NCT00773097 Phase 2
27 Chemoprevention With Folic Acid Completed NCT00018551 Phase 2 Folic Acid
28 A Clinical Trial of COX and EGFR Inhibition in Familial Polyposis Patients Completed NCT01187901 Phase 2 Erlotinib;Sulindac;Placebo A;Placebo B
29 T Cell Receptor Immunotherapy Targeting HPV-16 E6 for HPV-Associated Cancers Completed NCT02280811 Phase 1, Phase 2 Fludarabine;Cyclophosphamide;Aldesleukin
30 Aspirin in Preventing Colorectal Cancer in Patients With Colorectal Adenoma Recruiting NCT02965703 Phase 2 Aspirin
31 A Randomized, 2x2 Factorial Design Biomarker Prevention Trial of Low-dose Aspirin and Metformin in Stage I-III Colorectal Cancer Patients. Recruiting NCT03047837 Phase 2 Aspirin (ASA) + Metformin (MET);ASA;MET;Placebos
32 Vaccine Therapy in Treating Patients With Newly Diagnosed Advanced Colon Polyps Active, not recruiting NCT02134925 Phase 2
33 Panoramic Screening by Complete Colonoscopy in the Management of Colorectal Adenomas Not yet recruiting NCT03961893 Phase 2
34 Linaclotide in Treating Patients With Stages 0-3 Colorectal Cancer Not yet recruiting NCT03796884 Phase 2 Linaclotide
35 Polyphenon E in Treating Patients With High-Risk of Colorectal Cancer Terminated NCT01606124 Phase 2 defined green tea catechin extract
36 Celecoxib Window of Opportunity Trial to Assess Tumor and Stroma Responses Withdrawn NCT03185871 Phase 2 Celecoxib
37 Effect of Folate on Colon and Blood Cells Completed NCT00220012 Phase 1
38 Effect of Vitamin D and Calcium on Genes in the Colon Completed NCT00298545 Phase 1 placebo and Calcitriol;Calcium and Calcitriol
39 Detection of Colorectal Adenomas in Côte-d'Or Unknown status NCT02859714
40 Study of Prevalence of Colorectal Adenoma in 30- to 49-year-old Subjects With a Family History of Colorectal Cancer Unknown status NCT01428752
41 Comparison of Detection and Miss Rates of Blue Laser Imaging Versus Conventional White Light Colonoscopy Unknown status NCT02982447 Not Applicable
42 Detection of Colorectal Adenoma by Optical Enhancement Technology vs. High-Definition Colonoscopy Unknown status NCT02865382 Not Applicable
43 Effect of Single Colonoscopy on Colorectal Adenomas Detection Unknown status NCT02693886
44 Linked Color Imaging/Magnifying Blue Laser Imaging vs. White Light for Adenomas and Serrated Lesions in Proximal Colon Unknown status NCT02724397 Not Applicable
45 Aspirin and/or Folic Acid in Preventing Recurrent Colorectal Polyps Unknown status NCT00033319 Not Applicable acetylsalicylic acid
46 Endoscopic Full Thickness Resection in the Lower GI Tract With the "Full Thickness Resection Device" Unknown status NCT02362126
47 Intubation Techniques on Colonoscopy Quality (SINOCOLO2013) Unknown status NCT01919463 Not Applicable
48 Endocuff Adenoma Detection Rate Pilot Study Unknown status NCT01761097 Not Applicable
49 Effect of Water Exchange Method on Adenoma Miss Rates in Patients Undergoing Selective Polypectomy Unknown status NCT02880748 Not Applicable
50 Impact of DietarY and LIfestyle Risk Factors on Colorectal Cancer Screening Unknown status NCT02804802

Search NIH Clinical Center for Colorectal Adenoma

Genetic Tests for Colorectal Adenoma

Genetic tests related to Colorectal Adenoma:

# Genetic test Affiliating Genes
1 Colorectal Adenoma 30

Anatomical Context for Colorectal Adenoma

MalaCards organs/tissues related to Colorectal Adenoma:

42
Colon, Liver, Testes, Prostate, Bone, T Cells, Breast

The Foundational Model of Anatomy Ontology organs/tissues related to Colorectal Adenoma:

20
Colon, Rectum

Publications for Colorectal Adenoma

Articles related to Colorectal Adenoma:

(show top 50) (show all 764)
# Title Authors Year
1
A systematic review and quantitative assessment of methylation biomarkers in fecal DNA and colorectal cancer and its precursor, colorectal adenoma. ( 31097151 )
2019
2
Association of a New Germline Variant in the MUTYH DNA Glycosylase Gene with Colorectal Adenoma Transformation into Malignancy ( 31104418 )
2019
3
Metagenomic analyses of the gut microbiota associated with colorectal adenoma. ( 30794590 )
2019
4
Urine-NMR metabolomics for screening of advanced colorectal adenoma and early stage colorectal cancer. ( 30886205 )
2019
5
Doneness preferences, meat and meat-derived heterocyclic amines intake, and N-acetyltransferase 2 polymorphisms: association with colorectal adenoma in Japanese Brazilians. ( 30913095 )
2019
6
Effects of supplemental calcium and vitamin D on tight-junction proteins and mucin-12 expression in the normal rectal mucosa of colorectal adenoma patients. ( 30938860 )
2019
7
Role of miRNA in transformation from normal tissue to colorectal adenoma and cancer. ( 30964098 )
2019
8
Factors predicting the colorectal adenoma detection rate in colonoscopic screening of a Chinese population: A prospective study. ( 30985664 )
2019
9
Association of Family History With Cancer Recurrence, Survival, and the Incidence of Colorectal Adenoma in Patients With Colorectal Cancer. ( 30993089 )
2019
10
Altered miR-21, miRNA-148a Expression in Relation to KRAS Mutation Status as Indicator of Adenoma-Carcinoma Transitional Pattern in Colorectal Adenoma and Carcinoma Lesions. ( 30997628 )
2019
11
Arachidonic acid and colorectal adenoma risk: a Mendelian randomization study. ( 30588120 )
2019
12
No risk reduction of colorectal adenoma with aspirin or eicosapentaenoic acid. ( 30626898 )
2019
13
Effects of ursodeoxycholic acid on the gut microbiome and colorectal adenoma development. ( 30652422 )
2019
14
Association of TM6SF2 rs58542926 gene polymorphism with the risk of non-alcoholic fatty liver disease and colorectal adenoma in Chinese Han population. ( 30727943 )
2019
15
Liver fibrosis is associated with risk for colorectal adenoma in patients with nonalcoholic fatty liver disease. ( 30732129 )
2019
16
Hormone replacement therapies, oral contraceptives, reproductive factors and colorectal adenoma risk: a systematic review and dose-response meta-analysis of observational studies. ( 30748083 )
2019
17
Circulating inflammation markers and colorectal adenoma risk. ( 30753331 )
2019
18
Uncovering the clinical impact of kallikrein-related peptidase 5 (KLK5) mRNA expression in the colorectal adenoma-carcinoma sequence. ( 30759066 )
2019
19
The association between nonalcoholic fatty liver disease and risk of colorectal adenoma and cancer incident and recurrence: a meta-analysis of observational studies. ( 30791768 )
2019
20
Upregulation of Fibroblast Growth Factor 19 Is Associated with the Initiation of Colorectal Adenoma. ( 30517925 )
2019
21
Bioinformatics Analysis Reveals Most Prominent Gene Candidates to Distinguish Colorectal Adenoma from Adenocarcinoma. ( 30175151 )
2018
22
Histopathologic Features of Colorectal Adenoma and Adenocarcinoma Developing Within Inflammatory Polyps in Miniature Dachshunds. ( 29852840 )
2018
23
Effects of supplemental vitamin D and calcium on markers of proliferation, differentiation, and apoptosis in the normal colorectal mucosa of colorectal adenoma patients. ( 30557404 )
2018
24
Association between Colorectal Adenoma and Carotid Atherosclerosis in Korean Adults. ( 30563254 )
2018
25
Decreased Colorectal Adenoma Risk after Helicobacter pylori Eradication: A Retrospective Cohort Study. ( 30566695 )
2018
26
Telomere length in the colon is related to colorectal adenoma prevalence. ( 30332457 )
2018
27
Associations of Nut Intakes with Incident Sporadic Colorectal Adenoma: A Pooled Case-Control Study. ( 30372131 )
2018
28
Comparison of Pre- and Post-translational Expressions of COXIV-1 and MT-ATPase 6 Genes in Colorectal Adenoma-Carcinoma Tissues. ( 30393577 )
2018
29
Association of visceral adiposity and insulin resistance with colorectal adenoma and colorectal cancer. ( 30419640 )
2018
30
Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer. ( 30469315 )
2018
31
Effects of vitamin D and calcium on expression of MSH2 and transforming growth factors in normal-appearing colorectal mucosa of sporadic colorectal adenoma patients: A randomized clinical trial. ( 30499618 )
2018
32
Adherence to Nutrition and Physical Activity Cancer Prevention Guidelines and Development of Colorectal Adenoma. ( 30115827 )
2018
33
Vitamin D receptor FokI polymorphism and the risks of colorectal cancer, inflammatory bowel disease, and colorectal adenoma. ( 30150667 )
2018
34
Differences in risk factor-colorectal adenoma associations according to non-steroidal anti-inflammatory drug use. ( 30161027 )
2018
35
Association between red and processed meat intake and colorectal adenoma incidence and recurrence: a systematic review and meta-analysis. ( 30190793 )
2018
36
Effects of Supplemental Calcium and Vitamin D on Expression of Toll-Like Receptors and Phospho-IKKα/β in the Normal Rectal Mucosa of Colorectal Adenoma Patients. ( 30209117 )
2018
37
Association between oral health and colorectal adenoma in a screening population. ( 30212957 )
2018
38
Hepatitis B Virus Infection Is Independently Associated With Advanced Colorectal Adenoma. ( 30219156 )
2018
39
Dietary Heterocyclic Amine Intake and Colorectal Adenoma Risk: A Systematic Review and Meta-analysis. ( 30275115 )
2018
40
The study of bacteria in biopsies from Slovak colorectal adenoma and carcinoma patients. ( 29940777 )
2018
41
Predictors of High-Risk Adenoma Occurrence at Surveillance Colonoscopy in Patients Who Undergo Colorectal Adenoma Removal. ( 29969782 )
2018
42
miR-212 and mTOR form a regulation loop to modulate autophagy in colorectal adenoma HT-29 cells. ( 30021100 )
2018
43
Adiponectin, Leptin, IGF-1, and Tumor Necrosis Factor Alpha As Potential Serum Biomarkers for Non-Invasive Diagnosis of Colorectal Adenoma in African Americans. ( 29593647 )
2018
44
Age and gender may be the key points in hyperglycemic patients with Helicobacter pylori infection combined colorectal adenoma-author's reply. ( 29644785 )
2018
45
Hotspot KRAS exon 2 mutations in CD166 positive colorectal cancer and colorectal adenoma cells. ( 29755662 )
2018
46
Associations of Circulating 25-Hydroxyvitamin D3 Concentrations With Incident, Sporadic Colorectal Adenoma Risk According to Common Vitamin D-Binding Protein Isoforms. ( 29788105 )
2018
47
Polymorphisms in genes related to inflammation and obesity and colorectal adenoma risk. ( 29802748 )
2018
48
Age at menarche and risk of colorectal adenoma. ( 29843495 )
2018
49
Colorectal Adenoma Risk Is Increased among Recently Diagnosed Adult Celiac Disease Patients. ( 29849594 )
2018
50
Left-Sided Colectomy: One of the Important Risk Factors of Metachronous Colorectal Adenoma After Colectomy for Colon Cancer. ( 29417332 )
2018

Variations for Colorectal Adenoma

ClinVar genetic disease variations for Colorectal Adenoma:

6 (show all 26)
# Gene Variation Type Significance SNP ID Assembly Location
1 APC NM_000038.5(APC): c.3479C> A (p.Thr1160Lys) single nucleotide variant Conflicting interpretations of pathogenicity rs201004111 GRCh37 Chromosome 5, 112174770: 112174770
2 APC NM_000038.5(APC): c.3479C> A (p.Thr1160Lys) single nucleotide variant Conflicting interpretations of pathogenicity rs201004111 GRCh38 Chromosome 5, 112839073: 112839073
3 APC NM_000038.5(APC): c.7717A> G (p.Ile2573Val) single nucleotide variant Conflicting interpretations of pathogenicity rs145444830 GRCh37 Chromosome 5, 112179008: 112179008
4 APC NM_000038.5(APC): c.7717A> G (p.Ile2573Val) single nucleotide variant Conflicting interpretations of pathogenicity rs145444830 GRCh38 Chromosome 5, 112843311: 112843311
5 APC NM_000038.5(APC): c.4336G> A (p.Ala1446Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs146572883 GRCh38 Chromosome 5, 112839930: 112839930
6 APC NM_000038.5(APC): c.4336G> A (p.Ala1446Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs146572883 GRCh37 Chromosome 5, 112175627: 112175627
7 APC NM_000038.5(APC): c.4360A> G (p.Lys1454Glu) single nucleotide variant Conflicting interpretations of pathogenicity rs111866410 GRCh38 Chromosome 5, 112839954: 112839954
8 APC NM_000038.5(APC): c.4360A> G (p.Lys1454Glu) single nucleotide variant Conflicting interpretations of pathogenicity rs111866410 GRCh37 Chromosome 5, 112175651: 112175651
9 APC NM_000038.5(APC): c.4237A> G (p.Met1413Val) single nucleotide variant Conflicting interpretations of pathogenicity rs141519952 GRCh37 Chromosome 5, 112175528: 112175528
10 APC NM_000038.5(APC): c.4237A> G (p.Met1413Val) single nucleotide variant Conflicting interpretations of pathogenicity rs141519952 GRCh38 Chromosome 5, 112839831: 112839831
11 APC NM_000038.5(APC): c.4420G> A (p.Ala1474Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs139387758 GRCh37 Chromosome 5, 112175711: 112175711
12 APC NM_000038.5(APC): c.4420G> A (p.Ala1474Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs139387758 GRCh38 Chromosome 5, 112840014: 112840014
13 APC NM_000038.5(APC): c.6985A> G (p.Ile2329Val) single nucleotide variant Benign/Likely benign rs146048493 GRCh38 Chromosome 5, 112842579: 112842579
14 APC NM_000038.5(APC): c.6985A> G (p.Ile2329Val) single nucleotide variant Benign/Likely benign rs146048493 GRCh37 Chromosome 5, 112178276: 112178276
15 APC NM_000038.5(APC): c.8266A> G (p.Ile2756Val) single nucleotide variant Conflicting interpretations of pathogenicity rs146115809 GRCh38 Chromosome 5, 112843860: 112843860
16 APC NM_000038.5(APC): c.8266A> G (p.Ile2756Val) single nucleotide variant Conflicting interpretations of pathogenicity rs146115809 GRCh37 Chromosome 5, 112179557: 112179557
17 APC NM_000038.5(APC): c.4732T> G (p.Cys1578Gly) single nucleotide variant Conflicting interpretations of pathogenicity rs138367627 GRCh37 Chromosome 5, 112176023: 112176023
18 APC NM_000038.5(APC): c.4732T> G (p.Cys1578Gly) single nucleotide variant Conflicting interpretations of pathogenicity rs138367627 GRCh38 Chromosome 5, 112840326: 112840326
19 APC NM_000038.5(APC): c.8383G> A (p.Ala2795Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs369264968 GRCh37 Chromosome 5, 112179674: 112179674
20 APC NM_000038.5(APC): c.8383G> A (p.Ala2795Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs369264968 GRCh38 Chromosome 5, 112843977: 112843977
21 APC NM_000038.5(APC): c.449A> G (p.Lys150Arg) single nucleotide variant Uncertain significance rs371085910 GRCh37 Chromosome 5, 112111352: 112111352
22 APC NM_000038.5(APC): c.449A> G (p.Lys150Arg) single nucleotide variant Uncertain significance rs371085910 GRCh38 Chromosome 5, 112775655: 112775655
23 APC NM_000038.5(APC): c.2847G> T (p.Met949Ile) single nucleotide variant Conflicting interpretations of pathogenicity rs147394539 GRCh37 Chromosome 5, 112174138: 112174138
24 APC NM_000038.5(APC): c.2847G> T (p.Met949Ile) single nucleotide variant Conflicting interpretations of pathogenicity rs147394539 GRCh38 Chromosome 5, 112838441: 112838441
25 APC NM_000038.5(APC): c.7778A> G (p.Asn2593Ser) single nucleotide variant Uncertain significance rs367676584 GRCh37 Chromosome 5, 112179069: 112179069
26 APC NM_000038.5(APC): c.7778A> G (p.Asn2593Ser) single nucleotide variant Uncertain significance rs367676584 GRCh38 Chromosome 5, 112843372: 112843372

Expression for Colorectal Adenoma

LifeMap Discovery
Genes differentially expressed in tissues of Colorectal Adenoma patients vs. healthy controls: 35 (show top 50) (show all 255)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 GCG glucagon Colon - 9.14 0.000
2 GUCA2B guanylate cyclase activator 2B (uroguanylin) Colon - 8.78 0.000
3 MS4A12 membrane-spanning 4-domains, subfamily A, member 12 Colon - 8.78 0.000
4 AQP8 aquaporin 8 Colon - 8.30 0.000
5 CA1 carbonic anhydrase I Colon - 8.11 0.000
6 CLCA4 chloride channel accessory 4 Colon - 7.63 0.000
7 CA4 carbonic anhydrase IV Colon - 7.51 0.000
8 TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) Colon + 7.34 0.000
9 CLDN8 claudin 8 Colon - 7.18 0.000
10 CDH3 cadherin 3, type 1, P-cadherin (placental) Colon + 6.97 0.000
11 GUCA2A guanylate cyclase activator 2A (guanylin) Colon - 6.92 0.000
12 HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 Colon - 6.85 0.001
13 PRAC1 prostate cancer susceptibility candidate 1 Colon - 6.72 0.040
14 CEMIP cell migration inducing protein, hyaluronan binding Colon + 6.69 0.000
15 INSL5 insulin-like 5 Colon - 6.67 0.000
16 PYY peptide YY Colon - 6.57 0.000
17 SCNN1B sodium channel, non voltage gated 1 beta subunit Colon - 6.53 0.000
18 CHGA chromogranin A Colon - 6.30 0.000
19 SST somatostatin Colon - 5.99 0.000
20 ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) Colon - 5.77 0.002
21 SLC51B solute carrier family 51, beta subunit Colon - 5.54 0.001
22 CD177 CD177 molecule Colon - 5.52 0.003
23 GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) Colon - 5.48 0.000
24 SLC25A34 solute carrier family 25, member 34 Colon - 5.43 0.000
25 SLC26A3 solute carrier family 26 (anion exchanger), member 3 Colon - 5.39 0.002
26 CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) Colon - 5.35 0.000
27 ZG16 zymogen granule protein 16 Colon - 5.34 0.000
28 MSX2 msh homeobox 2 Colon + 5.31 0.000
29 FABP6 fatty acid binding protein 6, ileal Colon + 5.29 0.000
30 EPHX4 epoxide hydrolase 4 Colon + 5.24 0.000
31 DUSP27 dual specificity phosphatase 27 (putative) Colon + 5.23 0.000
32 TACSTD2 tumor-associated calcium signal transducer 2 Colon + 5.10 0.000
33 GABRP gamma-aminobutyric acid (GABA) A receptor, pi Colon + 5.08 0.003
34 BEST4 bestrophin 4 Colon - 5.08 0.001
35 S100A2 S100 calcium binding protein A2 Colon + 5.05 0.000
36 DPEP1 dipeptidase 1 (renal) Colon + 5.04 0.010
37 MUC12 mucin 12, cell surface associated Colon - 4.98 0.020
38 SPINK5 serine peptidase inhibitor, Kazal type 5 Colon - 4.96 0.001
39 PCSK1 proprotein convertase subtilisin/kexin type 1 Colon + 4.92 0.008
40 SLC30A10 solute carrier family 30, member 10 Colon - 4.89 0.003
41 TMEM72 transmembrane protein 72 Colon - 4.88 0.000
42 KLK10 kallikrein-related peptidase 10 Colon + 4.85 0.020
43 CDH19 cadherin 19, type 2 Colon - 4.83 0.001
44 CDKN2B-AS1 CDKN2B antisense RNA 1 Colon - 4.75 0.004
45 MT1M metallothionein 1M Colon - 4.75 0.027
46 SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 Colon - 4.71 0.007
47 PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) Colon - 4.70 0.000
48 ANO5 anoctamin 5 Colon - 4.68 0.000
49 FOXQ1 forkhead box Q1 Colon + 4.62 0.000
50 CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 Colon - 4.60 0.001
Search GEO for disease gene expression data for Colorectal Adenoma.

Pathways for Colorectal Adenoma

Pathways related to Colorectal Adenoma according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.92 APC CTNNB1 HRAS IGF1 KRAS PTGS2
2
Show member pathways
12.9 HRAS KRAS MLH1 MSH2 PTGS2 TP53
3
Show member pathways
12.67 APC CTNNB1 HRAS KRAS PTGS2 TP53
4
Show member pathways
12.67 APC CTNNB1 HRAS IGF1 KRAS MLH1
5
Show member pathways
12.64 APC CTNNB1 HRAS IGF1 KRAS MLH1
6
Show member pathways
12.56 CTNNB1 HRAS KRAS MSH2 TP53
7 12.53 APC CTNNB1 HRAS IGF1 KRAS MLH1
8 12.49 APC HRAS KRAS PTGS2 TP53
9 12.48 MGMT MLH1 MSH2 MUTYH TP53
10
Show member pathways
12.47 APC HRAS IGF1 KRAS TP53
11
Show member pathways
12.41 CTNNB1 HRAS KRAS TP53
12 12.39 APC CTNNB1 PTGS2 TP53
13
Show member pathways
12.37 CTNNB1 HRAS KRAS PTGS2
14
Show member pathways
12.37 APC CTNNB1 HRAS IGF1 KRAS
15
Show member pathways
12.36 HRAS IGF1 IGFBP3 TP53
16 12.31 APC CTNNB1 HRAS KRAS TP53
17
Show member pathways
12.28 CRP MTHFR MTR PTGS2 TP53
18 12.23 CTNNB1 HRAS IGF1 KRAS TP53
19 12.15 HRAS IGFBP3 KRAS TP53
20
Show member pathways
12.12 HRAS IGF1 KRAS TP53
21 12.08 CTNNB1 KRAS MSH2 ODC1 TP53
22 12.02 APC CTNNB1 HRAS IGF1 KRAS
23 11.99 APC CTNNB1 HRAS KRAS
24 11.96 CTNNB1 HRAS KRAS TP53
25 11.91 HRAS IGF1 IGFBP3 TP53
26 11.86 APC CTNNB1 HRAS KRAS TP53
27 11.85 APC IGFBP3 MLH1 MSH2 TP53 VDR
28 11.72 APC CTNNB1 KRAS MLH1 MSH2 PTGS2
29 11.71 HRAS KRAS TP53
30 11.71 MLH1 MSH2 TP53
31 11.65 HRAS KRAS TP53
32 11.65 HRAS KRAS TP53
33 11.61 HRAS IGF1 KRAS
34 11.59 CTNNB1 IGFBP3 PTGS2
35 11.51 HRAS KRAS PTGS2
36 11.51 HRAS KRAS MLH1 MSH2 TP53
37
Show member pathways
11.41 MLH1 MSH2 TP53
38
Show member pathways
11.4 MGMT MLH1 MSH2 NAT1
39 11.37 IGFBP3 PTGS2 TP53
40 11.28 HRAS KRAS TP53
41 11.21 APC CTNNB1 HRAS IGF1 KRAS MGMT
42
Show member pathways
11.16 HRAS IGF1 KRAS
43 11.15 APC CTNNB1 HRAS KRAS
44 10.8 HRAS KRAS

GO Terms for Colorectal Adenoma

Cellular components related to Colorectal Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 9.32 MLH1 MSH2
2 beta-catenin destruction complex GO:0030877 9.26 APC CTNNB1
3 Wnt signalosome GO:1990909 9.16 APC CTNNB1
4 insulin-like growth factor ternary complex GO:0042567 8.96 IGF1 IGFBP3
5 insulin-like growth factor binding protein complex GO:0016942 8.62 IGF1 IGFBP3

Biological processes related to Colorectal Adenoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.89 APC CTNNB1 IGFBP3 PTGS2 TP53
2 positive regulation of cell proliferation GO:0008284 9.88 CTNNB1 HRAS IGF1 KRAS ODC1 PTGS2
3 cellular response to DNA damage stimulus GO:0006974 9.8 APC MGMT MLH1 MSH2 MUTYH TP53
4 cell cycle arrest GO:0007050 9.76 APC HRAS MSH2 TP53
5 positive regulation of MAPK cascade GO:0043410 9.73 CTNNB1 HRAS IGF1 IGFBP3
6 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.58 IGF1 IGFBP3
7 methionine biosynthetic process GO:0009086 9.57 MTHFR MTR
8 negative regulation of blood vessel diameter GO:0097756 9.56 CRP PTGS2
9 positive regulation of isotype switching to IgG isotypes GO:0048304 9.55 MLH1 MSH2
10 response to folic acid GO:0051593 9.54 MGMT MTHFR
11 mismatch repair GO:0006298 9.54 MLH1 MSH2 MUTYH
12 response to isolation stress GO:0035900 9.52 HRAS KRAS
13 positive regulation of isotype switching to IgA isotypes GO:0048298 9.51 MLH1 MSH2
14 negative regulation of cell proliferation GO:0008285 9.5 APC CTNNB1 HRAS IGFBP3 PTGS2 TP53
15 somatic recombination of immunoglobulin gene segments GO:0016447 9.48 MLH1 MSH2
16 Ras protein signal transduction GO:0007265 9.46 HRAS IGF1 KRAS TP53
17 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.26 MLH1 MSH2
18 positive regulation of gene expression GO:0010628 9.17 CRP CTNNB1 HRAS IGF1 KRAS TP53

Molecular functions related to Colorectal Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 9.37 MLH1 MSH2
2 MutLalpha complex binding GO:0032405 9.32 MSH2 MUTYH
3 MutSalpha complex binding GO:0032407 9.26 MLH1 MUTYH
4 oxidized purine DNA binding GO:0032357 9.16 MSH2 MUTYH
5 enzyme binding GO:0019899 9.02 CTNNB1 MLH1 MSH2 PTGS2 TP53
6 guanine/thymine mispair binding GO:0032137 8.96 MLH1 MSH2

Sources for Colorectal Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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