MCID: CLR108
MIFTS: 60

Colorectal Adenoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Colorectal Adenoma

MalaCards integrated aliases for Colorectal Adenoma:

Name: Colorectal Adenoma 38 12 29 6 15
Adenoma of Large Intestine 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050860
UMLS 73 C1302401

Summaries for Colorectal Adenoma

MalaCards based summary : Colorectal Adenoma, also known as adenoma of large intestine, is related to polyposis syndrome, hereditary mixed, 1 and mutyh-associated polyposis. An important gene associated with Colorectal Adenoma is APC (APC, WNT Signaling Pathway Regulator), and among its related pathways/superpathways are TCR Signaling (Qiagen) and PI3K-Akt signaling pathway. The drugs Selenium and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and t cells, and related phenotypes are Increased shRNA abundance and homeostasis/metabolism

Wikipedia : 76 The colorectal adenoma is a benign glandular tumor of the colon and the rectum. It is a precursor lesion... more...

Related Diseases for Colorectal Adenoma

Diseases related to Colorectal Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)
# Related Disease Score Top Affiliating Genes
1 polyposis syndrome, hereditary mixed, 1 33.1 APC MLH1 MUTYH PTGS2
2 mutyh-associated polyposis 33.0 APC KRAS MUTYH TP53
3 mismatch repair cancer syndrome 32.1 APC CTNNB1 MLH1 MSH2
4 adenocarcinoma 29.4 APC CTNNB1 HRAS KRAS MLH1 PTGS2
5 familial colorectal cancer 29.3 APC MLH1 MSH2 MUTYH TP53
6 gastric cancer 29.2 APC CTNNB1 KRAS MLH1 MTHFR MUTYH
7 lynch syndrome 29.1 APC CTNNB1 KRAS MLH1 MSH2 MUTYH
8 familial adenomatous polyposis 28.8 APC CTNNB1 KRAS MLH1 MSH2 MUTYH
9 adenoma 28.7 APC CTNNB1 IGF1 KRAS MLH1 MSH2
10 prostate cancer 27.1 CTNNB1 HRAS IGF1 IGFBP3 KRAS PTGS2
11 breast cancer 25.1 APC CTNNB1 HRAS IGF1 IGFBP3 KRAS
12 colorectal cancer 24.6 APC CTNNB1 HRAS IGF1 IGFBP3 KRAS
13 familial adenomatous polyposis 2 11.6
14 colorectal cancer 1 11.2
15 colorectal cancer 12 11.2
16 desmoid disease, hereditary 10.9 APC CTNNB1
17 rare adenocarcinoma of the breast 10.9 KRAS TP53
18 protoplasmic astrocytoma 10.8 PTGS2 TP53
19 adult hepatocellular carcinoma 10.8 CTNNB1 TP53
20 familial adenomatous polyposis 1 10.8 APC CTNNB1
21 barrett's adenocarcinoma 10.7 KRAS PTGS2 TP53
22 colonic benign neoplasm 10.7 CTNNB1 KRAS PTGS2
23 homocystinuria due to deficiency of n -methylenetetrahydrofolate reductase activity 10.7 MTHFR MTR
24 juvenile polyposis syndrome 10.7 APC MUTYH PTGS2
25 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.7 CTNNB1 KRAS TP53
26 anal squamous cell carcinoma 10.7 APC MLH1 TP53
27 colon adenoma 10.7 APC KRAS VDR
28 peutz-jeghers syndrome 10.7 APC CTNNB1 TP53
29 ureteral obstruction 10.6 CTNNB1 PTGS2 TP53
30 cystitis 10.6 CRP PTGS2 TP53
31 endometrial adenocarcinoma 10.6 KRAS MLH1 TP53
32 hyperplastic polyposis syndrome 10.6 APC KRAS MUTYH TP53
33 mesenteric vascular occlusion 10.5 MTHFR ODC1
34 hepatoblastoma 10.5 APC CTNNB1 TP53
35 slipped capital femoral epiphysis 10.5 IGF1 IGFBP3
36 nutritional deficiency disease 10.5 CRP IGFBP3 MTHFR
37 sigmoid neoplasm 10.4 HRAS KRAS
38 central nervous system organ benign neoplasm 10.4 CTNNB1 IGF1 TP53
39 attenuated familial adenomatous polyposis 10.4 APC MSH2 MUTYH
40 homocysteinemia 10.4 CRP MTHFR MTR
41 appendix carcinoid tumor 10.4 MLH1 MSH2
42 adenosquamous colon carcinoma 10.4 MLH1 MSH2
43 organ system benign neoplasm 10.4 CTNNB1 IGF1 TP53
44 mastoiditis 10.4 CRP MTHFR
45 actinic cheilitis 10.4 MSH2 TP53
46 secondary adrenal insufficiency 10.3 IGF1 IGFBP3
47 apocrine adenoma 10.3 HRAS KRAS
48 barrett esophagus 10.3 APC ODC1 PTGS2 TP53
49 periampullary adenoma 10.3 APC HRAS KRAS
50 female reproductive endometrioid cancer 10.3 CTNNB1 TP53

Graphical network of the top 20 diseases related to Colorectal Adenoma:



Diseases related to Colorectal Adenoma

Symptoms & Phenotypes for Colorectal Adenoma

GenomeRNAi Phenotypes related to Colorectal Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 9.02 APC MLH1 MTHFR MTR MUTYH

MGI Mouse Phenotypes related to Colorectal Adenoma:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.48 EPHX1 CRP HRAS CTNNB1 APC KRAS
2 mortality/aging MP:0010768 10.41 APC DIDO1 HRAS CTNNB1 KRAS IGF1
3 cellular MP:0005384 10.37 CTNNB1 APC DIDO1 KRAS IGF1 PTGS2
4 integument MP:0010771 10.31 APC HRAS CTNNB1 KRAS IGF1 IGFBP3
5 cardiovascular system MP:0005385 10.3 CTNNB1 APC CRP HRAS KRAS IGF1
6 endocrine/exocrine gland MP:0005379 10.27 CTNNB1 APC KRAS IGF1 IGFBP3 HRAS
7 digestive/alimentary MP:0005381 10.24 APC HRAS CTNNB1 KRAS MLH1 MSH2
8 nervous system MP:0003631 10.23 APC HRAS CTNNB1 KRAS IGF1 MUTYH
9 neoplasm MP:0002006 10.22 EPHX1 HRAS CTNNB1 APC KRAS IGF1
10 embryo MP:0005380 10.18 CTNNB1 DIDO1 APC KRAS NAT1 ODC1
11 limbs/digits/tail MP:0005371 10.13 APC CTNNB1 KRAS IGF1 IGFBP3 MTHFR
12 muscle MP:0005369 10.1 CTNNB1 APC KRAS IGF1 IGFBP3 PTGS2
13 normal MP:0002873 10.06 CTNNB1 APC HRAS KRAS IGF1 PTGS2
14 hearing/vestibular/ear MP:0005377 10.03 CTNNB1 APC KRAS IGF1 VDR TP53
15 reproductive system MP:0005389 10 APC DIDO1 CTNNB1 KRAS IGF1 MLH1
16 no phenotypic analysis MP:0003012 9.98 CTNNB1 APC HRAS KRAS MTHFR TP53
17 renal/urinary system MP:0005367 9.97 APC HRAS CTNNB1 KRAS IGF1 IGFBP3
18 pigmentation MP:0001186 9.77 CTNNB1 APC IGFBP3 KRAS TP53
19 respiratory system MP:0005388 9.76 CTNNB1 KRAS IGF1 IGFBP3 HRAS PTGS2
20 skeleton MP:0005390 9.65 CTNNB1 APC KRAS IGF1 IGFBP3 HRAS
21 vision/eye MP:0005391 9.23 CTNNB1 APC KRAS PTGS2 NAT1 MLH1

Drugs & Therapeutics for Colorectal Adenoma

Drugs for Colorectal Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 105)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
2
Aspirin Approved, Vet_approved Phase 3,Phase 2,Not Applicable 50-78-2 2244
3
Celecoxib Approved, Investigational Phase 3,Phase 2 169590-42-5 2662
4
Calcium Carbonate Approved, Investigational Phase 2, Phase 3,Phase 3 471-34-1
5
Zinc Approved, Investigational Phase 3 7440-66-6 23994
6
Ergocalciferol Approved, Nutraceutical Phase 2, Phase 3,Phase 3,Phase 1 50-14-6 5280793
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 59-30-3 6037
8
leucovorin Approved, Nutraceutical Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 58-05-9 143 6006
9
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1 1406-16-2
10
Vitamin D3 Approved, Nutraceutical Phase 2, Phase 3,Phase 3,Phase 1 67-97-0 6221 5280795
11
Tocopherol Approved, Investigational, Nutraceutical Phase 3 1406-66-2 14986
12
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
13
Calcitriol Approved, Nutraceutical Phase 3,Phase 1 32222-06-3 134070 5280453
14
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 11103-57-4, 68-26-8 445354
15
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 5785 54670067
16 Bone Density Conservation Agents Phase 2, Phase 3,Phase 3,Phase 1
17 Calcium, Dietary Phase 2, Phase 3,Phase 3,Phase 1
18 Ergocalciferols Phase 2, Phase 3,Phase 3,Phase 1
19 Hematinics Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
20 Micronutrients Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
21 Trace Elements Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
22 Vitamin B Complex Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
23 Vitamins Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
24 Antioxidants Phase 3,Phase 2
25 Protective Agents Phase 3,Phase 2
26 Analgesics Phase 3,Phase 2,Not Applicable
27 Analgesics, Non-Narcotic Phase 3,Phase 2,Not Applicable
28 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
29 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 2,Not Applicable
30 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
31 Cyclooxygenase Inhibitors Phase 3,Phase 2,Not Applicable
32 Peripheral Nervous System Agents Phase 3,Phase 2,Not Applicable
33 Antipyretics Phase 3,Phase 2,Not Applicable
34 Fibrinolytic Agents Phase 3,Phase 2,Not Applicable
35 Platelet Aggregation Inhibitors Phase 3,Phase 2,Not Applicable
36 Cyclooxygenase 2 Inhibitors Phase 3,Phase 2
37 Antacids Phase 2, Phase 3,Phase 3
38 Anti-Ulcer Agents Phase 2, Phase 3,Phase 3
39 Gastrointestinal Agents Phase 2, Phase 3,Phase 3
40 Tocopherols Phase 3
41 Tocotrienols Phase 3
42 Dihydroxycholecalciferols Phase 3,Phase 1
43 Vasoconstrictor Agents Phase 3,Phase 1
44 Retinol palmitate Phase 3,Phase 2
45 Antimetabolites Phase 3,Phase 1,Phase 2
46 Acetylsalicylic acid lysinate Phase 3
47 Anticholesteremic Agents Phase 3
48 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
49 Hypolipidemic Agents Phase 3
50 Lipid Regulating Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 110)
# Name Status NCT ID Phase Drugs
1 Efficacy Combined Fecal Immunochemical Test-Sigmoidoscopy for the Detection of Advanced Colorectal Neoplasia Unknown status NCT01767870 Phase 4
2 Study of Folic Acid, Calcium and Vitamin D in Preventing Colorectal Polyps and Colorectal Cancer Unknown status NCT02066688 Phase 2, Phase 3 folic acid;folic acid calcium vitamin D3;calcium
3 Selenium for Prevention of Adenomatous Colorectal Polyps Unknown status NCT00078897 Phase 3 Selenium
4 A Study to Evaluate the Effect of MK0966 (Rofecoxib) on the Recurrence of Colorectal Adenomas (0966-122) Completed NCT00282386 Phase 3 MK0966; Rofecoxib / Duration of Treatment: 156 weeks;Placebo/ Duration of Treatment: 156 weeks
5 Prevention of Colorectal Sporadic Adenomatous Polyps (PRESAP) Completed NCT00141193 Phase 3 Celecoxib
6 Celecoxib to Prevent Colorectal Cancer in Patients Who Have Undergone Surgery to Remove Polyps Completed NCT00005094 Phase 3 celecoxib
7 Aspirin in Treating Patients With Colorectal Cancer That Has Been Surgically Removed Completed NCT00002527 Phase 3 aspirin
8 Vitamin D/Calcium Polyp Prevention Study Completed NCT00153816 Phase 2, Phase 3 Calcium Carbonate;Vitamin D3;placebo
9 Aspirin/Folate Prevention of Large Bowel Polyps Completed NCT00272324 Phase 2, Phase 3 Aspirin;Folate
10 S0000D: Effect of Vitamin E and/or Selenium on Colorectal Polyps in Men Enrolled on SELECT Trial SWOG-S0000 Completed NCT00706121 Phase 3 Vitamin E;Selenium;Vitamin E placebo;selenium placebo
11 A Research of Berberine Hydrochloride to Prevent Colorectal Adenomas in Patients With Previous Colorectal Cancer Recruiting NCT03281096 Phase 2, Phase 3 Berberine hydrochloride;Placebo
12 Study of Calcium Plus Vitamin D Supplementation in Prevention of Colorectal Adenomas Recurrence Recruiting NCT02143505 Phase 2, Phase 3 Ca plus vit D
13 Effect of Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch Syndrome Recruiting NCT02813824 Phase 3 Acetylsalicylic acid lysinate 300 mg;Placebo (for Aspirin 300);Acetylsalicylic acid lysinate 100 mg;Placebo 100 (for Aspirin 100)
14 Primary Chemoprevention of Familial Adenomatous Polyposis With Berberine Hydrochloride Recruiting NCT03333265 Phase 2, Phase 3 100mg Berberine hydrochloride;300mg Berberine hydrochloride;Placebo Oral Tablet
15 Aspirin for Prevention of Postsurgical Recurrence and Metastasis in Asian Colorectal Cancer Patients: a Multi-center Randomized Trial Recruiting NCT02607072 Phase 3 Acetylsalicylic acid (ASA)/aspirin 200 mg daily;Acetylsalicylic acid (ASA)/aspirin 100 mg daily;Placebo
16 Study of Berberine Hydrochloride in Prevention of Colorectal Adenomas Recurrence Active, not recruiting NCT02226185 Phase 2, Phase 3 Berberine hydrochloride;placebo
17 Vitamin D and Omega-3 Trial (VITAL) Active, not recruiting NCT01169259 Phase 3 omega-3 fatty acids (fish oil)
18 Chemoprevention of Colorectal Adenomas Terminated NCT00486512 Phase 3 aspirin, 1,25-dihydroxycholecalciferol, calcium;placebo
19 Antioxidant Supplement and Reduction of Metachronous Adenomas of the Large Bowel: a Double Blind Randomized Trial Terminated NCT01437826 Phase 3 antioxidants;placebo
20 APACC Study:Prospective Study on Aspirin Efficacy in Reducing Colorectal Adenoma Recurrence Terminated NCT00224679 Phase 3 Aspirin
21 Rosuvastatin in Treating Patients With Stage I or Stage II Colon Cancer That Was Removed By Surgery Terminated NCT01011478 Phase 3 rosuvastatin
22 Minimizing the Risk of Metachronous Adenomas of the Colorectum With Green Tea Extract -MIRACLE- Unknown status NCT01360320 Phase 2
23 Mesalazine Effects in Sporadic Colorectal Adenoma Patients Completed NCT01894685 Phase 2 Mesalazine;Placebo
24 Evaluation of Surgically Resected Colorectal Adenomas and Carcinomas After 7 Days Pretreatment With Celecoxib Completed NCT00582660 Phase 2 Celecoxib;Placebo
25 Trial of Metformin for Colorectal Cancer Risk Reduction for History of Colorectal Adenomas and Elevated BMI Completed NCT01312467 Phase 2 metformin hydrochloride
26 Study of the MUC1 Peptide-Poly-ICLC Adjuvant Vaccine in Individuals With Advanced Colorectal Adenoma Completed NCT00773097 Phase 2
27 Chemoprevention With Folic Acid Completed NCT00018551 Phase 2 Folic Acid
28 A Clinical Trial of COX and EGFR Inhibition in Familial Polyposis Patients Completed NCT01187901 Phase 2 Erlotinib;Sulindac;Placebo A;Placebo B
29 T Cell Receptor Immunotherapy Targeting HPV-16 E6 for HPV-Associated Cancers Completed NCT02280811 Phase 1, Phase 2 Fludarabine;Cyclophosphamide;Aldesleukin
30 Aspirin in Preventing Colorectal Cancer in Patients With Colorectal Adenoma Recruiting NCT02965703 Phase 2 Aspirin
31 A Randomized, 2x2 Factorial Design Biomarker Prevention Trial of Low-dose Aspirin and Metformin in Stage I-III Colorectal Cancer Patients. Recruiting NCT03047837 Phase 2 Aspirin (ASA) + Metformin (MET);ASA;MET;Placebos
32 Celecoxib Window of Opportunity Trial to Assess Tumor and Stroma Responses Recruiting NCT03185871 Phase 2 Celecoxib
33 Vaccine Therapy in Treating Patients With Newly Diagnosed Advanced Colon Polyps Active, not recruiting NCT02134925 Phase 2
34 Polyphenon E in Treating Patients With High-Risk of Colorectal Cancer Terminated NCT01606124 Phase 2 defined green tea catechin extract
35 Effect of Folate on Colon and Blood Cells Completed NCT00220012 Phase 1
36 Effect of Vitamin D and Calcium on Genes in the Colon Completed NCT00298545 Phase 1 placebo and Calcitriol;Calcium and Calcitriol
37 Detection of Colorectal Adenomas in Côte-d'Or Unknown status NCT02859714
38 Study of Prevalence of Colorectal Adenoma in 30- to 49-year-old Subjects With a Family History of Colorectal Cancer Unknown status NCT01428752
39 Effect of Single Colonoscopy on Colorectal Adenomas Detection Unknown status NCT02693886
40 Aspirin and/or Folic Acid in Preventing Recurrent Colorectal Polyps Unknown status NCT00033319 Not Applicable acetylsalicylic acid
41 Endoscopic Full Thickness Resection in the Lower GI Tract With the "Full Thickness Resection Device" Unknown status NCT02362126
42 Intubation Techniques on Colonoscopy Quality (SINOCOLO2013) Unknown status NCT01919463 Not Applicable
43 Endocuff Adenoma Detection Rate Pilot Study Unknown status NCT01761097 Not Applicable
44 Adenoma Detection by Polypectomy During Both Insertion and Withdrawal Unknown status NCT01925833 Not Applicable
45 Impact of DietarY and LIfestyle Risk Factors on Colorectal Cancer Screening Unknown status NCT02804802
46 Volatile Markers in Digestive Cancer Unknown status NCT02332213
47 Molecular Stool Testing for Colorectal Cancer Surveillance Unknown status NCT02715141
48 Efficacy of Cap-assisted Chromoendoscopy as a Screening Test for Colorectal Neoplasm Using Web-based Research Network Unknown status NCT01112280 Not Applicable
49 Evaluation of the Colonoscope With Vision to 330 ° (Full Spectrum Endoscopy) in the Detection of Colorectal Adenomas Completed NCT02859870
50 Green Tea Extracts for the Prevention of Colorectal Adenomas and Colorectal Cancer Completed NCT02321969 Not Applicable

Search NIH Clinical Center for Colorectal Adenoma

Genetic Tests for Colorectal Adenoma

Genetic tests related to Colorectal Adenoma:

# Genetic test Affiliating Genes
1 Colorectal Adenoma 29

Anatomical Context for Colorectal Adenoma

MalaCards organs/tissues related to Colorectal Adenoma:

41
Colon, Testes, T Cells, Liver, Bone, Prostate, Placenta

Publications for Colorectal Adenoma

Articles related to Colorectal Adenoma:

(show top 50) (show all 665)
# Title Authors Year
1
Family history of colorectal cancer in first-degree relatives and metachronous colorectal adenoma. ( 29463834 )
2018
2
Associations of Circulating 25-Hydroxyvitamin D3 Concentrations With Incident, Sporadic Colorectal Adenoma Risk According to Common Vitamin D Binding Protein Isoforms. ( 29788105 )
2018
3
Left-Sided Colectomy: One of the Important Risk Factors of Metachronous Colorectal Adenoma After Colectomy for Colon Cancer. ( 29417332 )
2018
4
Histopathologic Features of Colorectal Adenoma and Adenocarcinoma Developing Within Inflammatory Polyps in Miniature Dachshunds. ( 29852840 )
2018
5
Age and gender may be the key points in hyperglycemic patients with Helicobacter pylori infection combined colorectal adenoma-author's reply. ( 29644785 )
2018
6
Associations of mitochondrial polymorphisms with sporadic colorectal adenoma. ( 29323753 )
2018
7
Association between investigator-measured body-mass index and colorectal adenoma: a systematic review and meta-analysis of 168,201 subjects. ( 29288474 )
2018
8
Age and gender may be the key points in hyperglycemic patients with Helicobacter pylori infection combined colorectal adenoma. ( 29480547 )
2018
9
Different effects of metformin and insulin on primary and secondary chemoprevention of colorectal adenoma in diabetes type 2: Traditional and Bayesian meta-analysis. ( 29383018 )
2018
10
The Fatty Liver Index: A Simple and Accurate Predictor of Colorectal Adenoma in an Average-Risk Population. ( 29219920 )
2018
11
Colorectal Adenoma Risk Is Increased among Recently Diagnosed Adult Celiac Disease Patients. ( 29849594 )
2018
12
Meat Mutagens and Colorectal Adenoma and Cancer: A Problem with a Recently Published Systematic Review and Meta-Analysis. ( 29509700 )
2018
13
Impaired Secretion of Glucagon-Like Peptide 1 in Patients with Colorectal Adenoma after an Oral Glucose Load. ( 29539609 )
2018
14
A Novel Application of Structural Equation Modeling Estimates the Association between Oxidative Stress and Colorectal Adenoma. ( 29074536 )
2018
15
The study of bacteria in biopsies from Slovak colorectal adenoma and carcinoma patients. ( 29940777 )
2018
16
Identification of Kininogen 1 as a Serum Protein Marker of Colorectal Adenoma in Patients with a Family History of Colorectal Cancer. ( 29535795 )
2018
17
Visceral obesity as a risk factor for colorectal adenoma occurrence in surveillance colonoscopy. ( 29510147 )
2018
18
Resting heart rate is an independent predictor of advanced colorectal adenoma recurrence. ( 29499053 )
2018
19
Polymorphisms in genes related to inflammation and obesity and colorectal adenoma risk. ( 29802748 )
2018
20
Variation in Pathologist Classification of Colorectal Adenomas and Serrated Polyps. ( 29380819 )
2018
21
Colorectal adenoma risk in childhood cancer survivors. ( 29526391 )
2018
22
Predictors of High-Risk Adenoma Occurrence at Surveillance Colonoscopy in Patients Who Undergo Colorectal Adenoma Removal. ( 29969782 )
2018
23
Hotspot <i>KRAS</i> exon 2 mutations in CD166 positive colorectal cancer and colorectal adenoma cells. ( 29755662 )
2018
24
Age at menarche and risk of colorectal adenoma. ( 29843495 )
2018
25
Discovery and Validation of Circulating Biomarkers of Colorectal Adenoma by High-Depth Small RNA Sequencing. ( 29490987 )
2018
26
Adiponectin, Leptin, IGF-1, and Tumor Necrosis Factor Alpha As Potential Serum Biomarkers for Non-Invasive Diagnosis of Colorectal Adenoma in African Americans. ( 29593647 )
2018
27
Global and targeted circulating microRNA profiling of colorectal adenoma and colorectal cancer. ( 29112225 )
2018
28
Gallbladder stones and gallbladder polyps associated with increased risk of colorectal adenoma in men. ( 28971517 )
2017
29
Expression of circadian clock genes in human colorectal adenoma and carcinoma. ( 29113166 )
2017
30
Abdominal fat distribution measured using computed tomography is associated with an increased risk of colorectal adenoma in men. ( 28906398 )
2017
31
Measurement of biological age may help to assess the risk of colorectal adenoma in screening colonoscopy. ( 29085230 )
2017
32
Association between dietary fat intake and colorectal adenoma in korean adults: A cross-sectional study. ( 28072719 )
2017
33
Lumican and versican protein expression are associated with colorectal adenoma-to-carcinoma progression. ( 28481899 )
2017
34
Association of plasma C-reactive protein level with the prevalence of colorectal adenoma: the Colorectal Adenoma Study in Tokyo. ( 28667300 )
2017
35
The association between location, age and advanced colorectal adenoma characteristics: a propensity-matched analysis. ( 27686516 )
2017
36
Low-grade slightly elevated and polypoid colorectal adenomas display differential I^-catenin-TCF/LEF activity, c-Myc, and cyclin D1 expression. ( 28533663 )
2017
37
Temporal and spatial changes of cells positive for stem-like markers in different compartments and stages of human colorectal adenoma-carcinoma sequence. ( 28484082 )
2017
38
Cardiovascular Risk and Known Coronary Artery Disease Are Associated With Colorectal Adenoma and Advanced Neoplasia. ( 28473143 )
2017
39
Colorectal adenoma and cancer detection based on altered methylation pattern of SFRP1, SFRP2, SDC2, and PRIMA1 in plasma samples. ( 28753106 )
2017
40
Dietary Intake of Meat Cooking-Related Mutagens (HCAs) and Risk of Colorectal Adenoma and Cancer: A Systematic Review and Meta-Analysis. ( 28524104 )
2017
41
Metabolically-healthy obesity is associated with higher prevalence of colorectal adenoma. ( 28636624 )
2017
42
Visceral Adipose Tissue Volume and the Occurrence of Colorectal Adenoma in Follow-up Colonoscopy for Screening and Surveillance. ( 28569608 )
2017
43
Vitamin D Receptor Genotype, Vitamin D3 Supplementation, and Risk of Colorectal Adenomas: A Randomized Clinical Trial. ( 27978548 )
2017
44
The SEPT9 gene methylation assay is capable of detecting colorectal adenoma in opportunistic screening. ( 28470092 )
2017
45
The Frequency and Risk Factors of Colorectal Adenoma in Patients with Early Gastric Cancer. ( 28675538 )
2017
46
PUFA levels in erythrocyte membrane phospholipids are differentially associated with colorectal adenoma risk. ( 28660850 )
2017
47
Synergistic Effect of Hyperglycemia and Helicobacterpylori Infection Status on Colorectal Adenoma Risk. ( 28475740 )
2017
48
Functional Genomic mRNA Profiling of Colorectal Adenomas: Identification and<i>in vivo</i>Validation of CD44 and Splice Variant CD44v6 as Molecular Imaging Targets. ( 28255344 )
2017
49
Circulating folate levels and colorectal adenoma: a case-control study and a meta-analysis. ( 28989579 )
2017
50
Evaluation of the Expression of the Inhibitor of Apoptosis Protein Family and Human Telomerase Reverse Transcriptase in Patients With Advanced Colorectal Adenoma. ( 28698863 )
2017

Variations for Colorectal Adenoma

ClinVar genetic disease variations for Colorectal Adenoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 APC NM_000038.5(APC): c.2847G> T (p.Met949Ile) single nucleotide variant Conflicting interpretations of pathogenicity rs147394539 GRCh37 Chromosome 5, 112174138: 112174138
2 APC NM_000038.5(APC): c.2847G> T (p.Met949Ile) single nucleotide variant Conflicting interpretations of pathogenicity rs147394539 GRCh38 Chromosome 5, 112838441: 112838441
3 APC NM_000038.5(APC): c.7778A> G (p.Asn2593Ser) single nucleotide variant Uncertain significance rs367676584 GRCh37 Chromosome 5, 112179069: 112179069
4 APC NM_000038.5(APC): c.7778A> G (p.Asn2593Ser) single nucleotide variant Uncertain significance rs367676584 GRCh38 Chromosome 5, 112843372: 112843372

Expression for Colorectal Adenoma

LifeMap Discovery
Genes differentially expressed in tissues of Colorectal Adenoma patients vs. healthy controls: 35 (show top 50) (show all 255)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 GCG glucagon Colon - 9.14 0.000
2 GUCA2B guanylate cyclase activator 2B (uroguanylin) Colon - 8.78 0.000
3 MS4A12 membrane-spanning 4-domains, subfamily A, member 12 Colon - 8.78 0.000
4 AQP8 aquaporin 8 Colon - 8.30 0.000
5 CA1 carbonic anhydrase I Colon - 8.11 0.000
6 CLCA4 chloride channel accessory 4 Colon - 7.63 0.000
7 CA4 carbonic anhydrase IV Colon - 7.51 0.000
8 TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) Colon + 7.34 0.000
9 CLDN8 claudin 8 Colon - 7.18 0.000
10 CDH3 cadherin 3, type 1, P-cadherin (placental) Colon + 6.97 0.000
11 GUCA2A guanylate cyclase activator 2A (guanylin) Colon - 6.92 0.000
12 HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 Colon - 6.85 0.001
13 PRAC1 prostate cancer susceptibility candidate 1 Colon - 6.72 0.040
14 CEMIP cell migration inducing protein, hyaluronan binding Colon + 6.69 0.000
15 INSL5 insulin-like 5 Colon - 6.67 0.000
16 PYY peptide YY Colon - 6.57 0.000
17 SCNN1B sodium channel, non voltage gated 1 beta subunit Colon - 6.53 0.000
18 CHGA chromogranin A Colon - 6.30 0.000
19 SST somatostatin Colon - 5.99 0.000
20 ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) Colon - 5.77 0.002
21 SLC51B solute carrier family 51, beta subunit Colon - 5.54 0.001
22 CD177 CD177 molecule Colon - 5.52 0.003
23 GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) Colon - 5.48 0.000
24 SLC25A34 solute carrier family 25, member 34 Colon - 5.43 0.000
25 SLC26A3 solute carrier family 26 (anion exchanger), member 3 Colon - 5.39 0.002
26 CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) Colon - 5.35 0.000
27 ZG16 zymogen granule protein 16 Colon - 5.34 0.000
28 MSX2 msh homeobox 2 Colon + 5.31 0.000
29 FABP6 fatty acid binding protein 6, ileal Colon + 5.29 0.000
30 EPHX4 epoxide hydrolase 4 Colon + 5.24 0.000
31 DUSP27 dual specificity phosphatase 27 (putative) Colon + 5.23 0.000
32 TACSTD2 tumor-associated calcium signal transducer 2 Colon + 5.10 0.000
33 GABRP gamma-aminobutyric acid (GABA) A receptor, pi Colon + 5.08 0.003
34 BEST4 bestrophin 4 Colon - 5.08 0.001
35 S100A2 S100 calcium binding protein A2 Colon + 5.05 0.000
36 DPEP1 dipeptidase 1 (renal) Colon + 5.04 0.010
37 MUC12 mucin 12, cell surface associated Colon - 4.98 0.020
38 SPINK5 serine peptidase inhibitor, Kazal type 5 Colon - 4.96 0.001
39 PCSK1 proprotein convertase subtilisin/kexin type 1 Colon + 4.92 0.008
40 SLC30A10 solute carrier family 30, member 10 Colon - 4.89 0.003
41 TMEM72 transmembrane protein 72 Colon - 4.88 0.000
42 KLK10 kallikrein-related peptidase 10 Colon + 4.85 0.020
43 CDH19 cadherin 19, type 2 Colon - 4.83 0.001
44 CDKN2B-AS1 CDKN2B antisense RNA 1 Colon - 4.75 0.004
45 MT1M metallothionein 1M Colon - 4.75 0.027
46 SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 Colon - 4.71 0.007
47 PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) Colon - 4.70 0.000
48 ANO5 anoctamin 5 Colon - 4.68 0.000
49 FOXQ1 forkhead box Q1 Colon + 4.62 0.000
50 CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 Colon - 4.60 0.001
Search GEO for disease gene expression data for Colorectal Adenoma.

Pathways for Colorectal Adenoma

Pathways related to Colorectal Adenoma according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.9 HRAS KRAS MLH1 MSH2 PTGS2 TP53
2
Show member pathways
12.88 APC CTNNB1 HRAS IGF1 KRAS PTGS2
3
Show member pathways
12.67 APC CTNNB1 HRAS IGF1 KRAS MLH1
4
Show member pathways
12.64 APC CTNNB1 HRAS KRAS PTGS2 TP53
5
Show member pathways
12.64 APC CTNNB1 HRAS IGF1 KRAS MLH1
6
Show member pathways
12.57 CTNNB1 HRAS KRAS MSH2 TP53
7
Show member pathways
12.54 CTNNB1 HRAS KRAS PTGS2 TP53
8 12.48 APC HRAS KRAS PTGS2 TP53
9
Show member pathways
12.45 APC HRAS IGF1 KRAS TP53
10
Show member pathways
12.4 CTNNB1 HRAS KRAS TP53
11 12.37 APC CTNNB1 HRAS KRAS TP53
12
Show member pathways
12.36 CTNNB1 HRAS KRAS PTGS2
13 12.33 APC CTNNB1 HRAS IGF1 KRAS MLH1
14
Show member pathways
12.25 CRP MTHFR MTR PTGS2 TP53
15 12.2 CTNNB1 HRAS IGF1 KRAS TP53
16 12.15 HRAS IGFBP3 KRAS TP53
17
Show member pathways
12.11 HRAS IGF1 KRAS TP53
18 12.06 CTNNB1 KRAS MSH2 ODC1 TP53
19
Show member pathways
12 HRAS IGF1 IGFBP3 TP53
20 12 APC CTNNB1 HRAS IGF1 KRAS
21 11.97 APC CTNNB1 HRAS KRAS
22 11.94 CTNNB1 HRAS KRAS TP53
23 11.88 HRAS IGF1 IGFBP3 TP53
24 11.86 APC CTNNB1 HRAS KRAS TP53
25 11.85 APC IGFBP3 MLH1 MSH2 TP53 VDR
26 11.71 HRAS KRAS TP53
27 11.71 MLH1 MSH2 TP53
28 11.68 APC CTNNB1 HRAS IGF1 KRAS TP53
29 11.65 HRAS KRAS TP53
30 11.65 HRAS KRAS TP53
31 11.61 HRAS IGF1 KRAS
32 11.59 CTNNB1 IGFBP3 PTGS2
33 11.51 HRAS KRAS PTGS2
34
Show member pathways
11.45 MLH1 MSH2 NAT1
35
Show member pathways
11.4 MLH1 MSH2 TP53
36 11.38 APC CTNNB1 KRAS MLH1 MSH2 PTGS2
37 11.36 IGFBP3 PTGS2 TP53
38 11.15 APC CTNNB1 HRAS KRAS
39
Show member pathways
11.14 HRAS IGF1 KRAS
40 10.79 HRAS KRAS

GO Terms for Colorectal Adenoma

Cellular components related to Colorectal Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 9.32 MLH1 MSH2
2 beta-catenin destruction complex GO:0030877 9.26 APC CTNNB1
3 Wnt signalosome GO:1990909 9.16 APC CTNNB1
4 insulin-like growth factor ternary complex GO:0042567 8.96 IGF1 IGFBP3
5 insulin-like growth factor binding protein complex GO:0016942 8.62 IGF1 IGFBP3

Biological processes related to Colorectal Adenoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.95 APC MLH1 MSH2 MUTYH TP53
2 cell proliferation GO:0008283 9.91 APC CTNNB1 HRAS IGF1 TP53
3 positive regulation of apoptotic process GO:0043065 9.85 APC CTNNB1 IGFBP3 PTGS2 TP53
4 positive regulation of cell proliferation GO:0008284 9.85 CTNNB1 HRAS IGF1 KRAS ODC1 PTGS2
5 positive regulation of MAPK cascade GO:0043410 9.73 CTNNB1 HRAS IGF1 IGFBP3
6 cell cycle arrest GO:0007050 9.71 APC HRAS MSH2 TP53
7 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.58 IGF1 IGFBP3
8 determination of adult lifespan GO:0008340 9.57 MSH2 TP53
9 negative regulation of blood vessel diameter GO:0097756 9.56 CRP PTGS2
10 positive regulation of isotype switching to IgG isotypes GO:0048304 9.54 MLH1 MSH2
11 response to isolation stress GO:0035900 9.52 HRAS KRAS
12 mismatch repair GO:0006298 9.5 MLH1 MSH2 MUTYH
13 negative regulation of cell proliferation GO:0008285 9.5 APC CTNNB1 HRAS IGFBP3 PTGS2 TP53
14 positive regulation of isotype switching to IgA isotypes GO:0048298 9.49 MLH1 MSH2
15 somatic recombination of immunoglobulin gene segments GO:0016447 9.48 MLH1 MSH2
16 Ras protein signal transduction GO:0007265 9.46 HRAS IGF1 KRAS TP53
17 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.26 MLH1 MSH2
18 positive regulation of gene expression GO:0010628 9.17 CRP CTNNB1 HRAS IGF1 KRAS TP53

Molecular functions related to Colorectal Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 9.32 MLH1 MSH2
2 oxidized purine DNA binding GO:0032357 9.26 MSH2 MUTYH
3 MutLalpha complex binding GO:0032405 9.16 MSH2 MUTYH
4 MutSalpha complex binding GO:0032407 8.96 MLH1 MUTYH
5 guanine/thymine mispair binding GO:0032137 8.62 MLH1 MSH2

Sources for Colorectal Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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