MCID: CLR108
MIFTS: 61

Colorectal Adenoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Colorectal Adenoma

MalaCards integrated aliases for Colorectal Adenoma:

Name: Colorectal Adenoma 38 12 29 6 15
Adenoma of Large Intestine 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050860
UMLS 73 C1302401

Summaries for Colorectal Adenoma

MalaCards based summary : Colorectal Adenoma, also known as adenoma of large intestine, is related to mutyh-associated polyposis and polyposis syndrome, hereditary mixed, 1. An important gene associated with Colorectal Adenoma is APC (APC, WNT Signaling Pathway Regulator), and among its related pathways/superpathways are PI3K-Akt signaling pathway and TCR Signaling (Qiagen). The drugs leucovorin and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and t cells, and related phenotypes are Increased shRNA abundance and homeostasis/metabolism

Wikipedia : 76 The colorectal adenoma is a benign glandular tumor of the colon and the rectum. It is a precursor lesion... more...

Related Diseases for Colorectal Adenoma

Diseases related to Colorectal Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 mutyh-associated polyposis 32.7 APC KRAS MUTYH TP53
2 polyposis syndrome, hereditary mixed, 1 32.3 APC MLH1 MUTYH PTGS2
3 mismatch repair cancer syndrome 32.3 APC CTNNB1 MLH1 MSH2
4 adenoma 30.9 APC CTNNB1 IGF1 KRAS MLH1 MSH2
5 adenocarcinoma 30.5 APC CTNNB1 HRAS KRAS MLH1 PTGS2
6 lynch syndrome 30.1 APC CTNNB1 KRAS MLH1 MSH2 MUTYH
7 familial adenomatous polyposis 29.8 APC CTNNB1 KRAS MLH1 MSH2 MUTYH
8 nutritional deficiency disease 29.7 CRP IGF1 IGFBP3 MTHFR
9 ulcerative colitis 29.6 CRP CTNNB1 MLH1 MSH2
10 familial colorectal cancer 29.6 APC MLH1 MSH2 MUTYH TP53
11 cervical cancer 29.4 CTNNB1 HRAS IGFBP3 PTGS2 TP53
12 osteoporosis 29.4 CRP CTNNB1 IGF1 IGFBP3 VDR
13 gastric cancer 29.3 APC CTNNB1 KRAS MLH1 MSH2 MTHFR
14 prostate cancer 29.1 CTNNB1 HRAS IGF1 IGFBP3 KRAS PTGS2
15 colorectal cancer 29.0 APC CTNNB1 HRAS IGF1 IGFBP3 KRAS
16 breast cancer 28.3 APC CTNNB1 HRAS IGF1 IGFBP3 KRAS
17 familial adenomatous polyposis 2 11.8
18 colorectal cancer 1 11.4
19 colorectal cancer 12 11.3
20 desmoid disease, hereditary 10.3 APC CTNNB1
21 leukorrhea 10.3 CRP PTGS2
22 adult hepatocellular carcinoma 10.3 CTNNB1 TP53
23 rare adenocarcinoma of the breast 10.3 KRAS TP53
24 familial adenomatous polyposis 1 10.3 APC CTNNB1
25 juvenile polyposis syndrome 10.2 APC MUTYH PTGS2
26 homocystinuria due to deficiency of n -methylenetetrahydrofolate reductase activity 10.2 MTHFR MTR
27 protoplasmic astrocytoma 10.2 PTGS2 TP53
28 barrett's adenocarcinoma 10.2 KRAS PTGS2 TP53
29 colonic benign neoplasm 10.2 CTNNB1 KRAS PTGS2
30 colon adenoma 10.2 APC KRAS VDR
31 anal squamous cell carcinoma 10.2 APC MLH1 TP53
32 peutz-jeghers syndrome 10.2 APC CTNNB1 TP53
33 ureteral obstruction 10.2 CTNNB1 PTGS2 TP53
34 helicobacter pylori infection 10.2
35 body mass index quantitative trait locus 1 10.2
36 intrahepatic cholangiocarcinoma 10.2 CTNNB1 KRAS TP53
37 hyperplastic polyposis syndrome 10.2 APC KRAS MUTYH TP53
38 mesenteric vascular occlusion 10.2 MTHFR ODC1
39 hepatoblastoma 10.2 APC CTNNB1 TP53
40 slipped capital femoral epiphysis 10.1 IGF1 IGFBP3
41 homocysteinemia 10.1 CRP MTHFR MTR
42 sigmoid neoplasm 10.1 HRAS KRAS
43 appendix carcinoid tumor 10.1 MLH1 MSH2
44 attenuated familial adenomatous polyposis 10.1 APC MSH2 MUTYH
45 colorectal cancer, hereditary nonpolyposis, type 7 10.1 MLH1 MSH2
46 stomach disease 10.1 CTNNB1 MLH1 PTGS2 TP53
47 gallbladder cancer 10.1 KRAS MLH1 PTGS2 TP53
48 adenosquamous colon carcinoma 10.1 MLH1 MSH2
49 endometrial adenocarcinoma 10.1 CTNNB1 KRAS MLH1 TP53
50 secondary adrenal insufficiency 10.1 IGF1 IGFBP3

Graphical network of the top 20 diseases related to Colorectal Adenoma:



Diseases related to Colorectal Adenoma

Symptoms & Phenotypes for Colorectal Adenoma

GenomeRNAi Phenotypes related to Colorectal Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 9.02 APC MLH1 MTHFR MTR MUTYH

MGI Mouse Phenotypes related to Colorectal Adenoma:

46 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.5 APC CRP CTNNB1 EPHX1 HRAS IGF1
2 mortality/aging MP:0010768 10.41 APC CTNNB1 DIDO1 HRAS IGF1 KRAS
3 cellular MP:0005384 10.38 APC CTNNB1 DIDO1 IGF1 KRAS MLH1
4 integument MP:0010771 10.33 APC CTNNB1 HRAS IGF1 IGFBP3 KRAS
5 cardiovascular system MP:0005385 10.31 APC CRP CTNNB1 HRAS IGF1 IGFBP3
6 immune system MP:0005387 10.3 APC CRP CTNNB1 DIDO1 IGF1 KRAS
7 endocrine/exocrine gland MP:0005379 10.28 APC CTNNB1 HRAS IGF1 IGFBP3 KRAS
8 digestive/alimentary MP:0005381 10.25 APC CTNNB1 HRAS KRAS MLH1 MSH2
9 nervous system MP:0003631 10.23 APC CTNNB1 HRAS IGF1 KRAS MSH2
10 neoplasm MP:0002006 10.22 APC CTNNB1 EPHX1 HRAS IGF1 KRAS
11 embryo MP:0005380 10.19 APC CTNNB1 DIDO1 KRAS NAT1 ODC1
12 limbs/digits/tail MP:0005371 10.14 APC CTNNB1 IGF1 IGFBP3 KRAS MTHFR
13 muscle MP:0005369 10.1 APC CTNNB1 IGF1 IGFBP3 KRAS PTGS2
14 liver/biliary system MP:0005370 10.07 APC CTNNB1 IGFBP3 KRAS MTHFR PTGS2
15 normal MP:0002873 10.06 APC CTNNB1 HRAS IGF1 KRAS NAT1
16 hearing/vestibular/ear MP:0005377 10.05 APC CTNNB1 IGF1 KRAS TP53 VDR
17 reproductive system MP:0005389 10 APC CTNNB1 DIDO1 IGF1 KRAS MLH1
18 no phenotypic analysis MP:0003012 9.98 APC CTNNB1 HRAS KRAS MTHFR PTGS2
19 renal/urinary system MP:0005367 9.97 APC CTNNB1 HRAS IGF1 IGFBP3 KRAS
20 pigmentation MP:0001186 9.77 APC CTNNB1 IGFBP3 KRAS TP53
21 respiratory system MP:0005388 9.76 CTNNB1 HRAS IGF1 IGFBP3 KRAS MLH1
22 skeleton MP:0005390 9.65 APC CTNNB1 HRAS IGF1 IGFBP3 KRAS
23 vision/eye MP:0005391 9.23 APC CTNNB1 KRAS MLH1 MTHFR NAT1

Drugs & Therapeutics for Colorectal Adenoma

Drugs for Colorectal Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 101)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 58-05-9 6006 143
2
Aspirin Approved, Vet_approved Phase 3,Phase 2,Not Applicable 50-78-2 2244
3
Celecoxib Approved, Investigational Phase 3,Phase 2 169590-42-5 2662
4
Calcium Carbonate Approved, Investigational Phase 2, Phase 3,Phase 3 471-34-1
5
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
6
Tocopherol Approved, Investigational Phase 3 1406-66-2 14986
7
Zinc Approved, Investigational Phase 3 7440-66-6
8
Ergocalciferol Approved, Nutraceutical Phase 2, Phase 3,Phase 3,Phase 1 50-14-6 5280793
9
Vitamin D3 Approved, Nutraceutical Phase 2, Phase 3,Phase 3,Phase 1 67-97-0 5280795 6221
10
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1 1406-16-2
11
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 59-30-3 6037
12
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
13
Calcitriol Approved, Nutraceutical Phase 3,Phase 1 32222-06-3 5280453 134070
14
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 11103-57-4, 68-26-8 445354
15
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 5785 54670067
16 Tocotrienol Investigational Phase 3 6829-55-6
17 Vitamin B Complex Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
18 Ergocalciferols Phase 2, Phase 3,Phase 3,Phase 1
19 Vitamin B9 Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
20 Micronutrients Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
21 Calciferol Phase 2, Phase 3,Phase 3,Phase 1
22 Calcium, Dietary Phase 2, Phase 3,Phase 3,Phase 1
23 Vitamin D2 Phase 2, Phase 3,Phase 3,Phase 1
24 Vitamins Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
25 Folate Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
26 Hematinics Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
27 Trace Elements Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
28 Bone Density Conservation Agents Phase 2, Phase 3,Phase 3,Phase 1
29 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
30 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 2,Not Applicable
31 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
32 Cyclooxygenase Inhibitors Phase 3,Phase 2,Not Applicable
33 Peripheral Nervous System Agents Phase 3,Phase 2,Not Applicable
34 Analgesics, Non-Narcotic Phase 3,Phase 2,Not Applicable
35 Analgesics Phase 3,Phase 2,Not Applicable
36 Cola Phase 3,Phase 2,Phase 1,Not Applicable
37 Platelet Aggregation Inhibitors Phase 3,Phase 2,Not Applicable
38 Fibrinolytic Agents Phase 3,Phase 2,Not Applicable
39 Antipyretics Phase 3,Phase 2,Not Applicable
40 Cyclooxygenase 2 Inhibitors Phase 3,Phase 2
41 Antacids Phase 2, Phase 3,Phase 3
42 Anti-Ulcer Agents Phase 2, Phase 3,Phase 3
43 Gastrointestinal Agents Phase 2, Phase 3,Phase 3
44 Tocotrienols Phase 3
45 Antioxidants Phase 3,Phase 2
46 Protective Agents Phase 3,Phase 2,Not Applicable
47 Tocopherols Phase 3
48 Vasoconstrictor Agents Phase 3,Phase 1
49 Dihydroxycholecalciferols Phase 3,Phase 1
50 retinol Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 119)
# Name Status NCT ID Phase Drugs
1 Efficacy Combined Fecal Immunochemical Test-Sigmoidoscopy for the Detection of Advanced Colorectal Neoplasia Unknown status NCT01767870 Phase 4
2 Study of Folic Acid, Calcium and Vitamin D in Preventing Colorectal Polyps and Colorectal Cancer Unknown status NCT02066688 Phase 2, Phase 3 folic acid;folic acid calcium vitamin D3;calcium
3 A Study to Evaluate the Effect of MK0966 (Rofecoxib) on the Recurrence of Colorectal Adenomas (0966-122) Completed NCT00282386 Phase 3 MK0966; Rofecoxib / Duration of Treatment: 156 weeks;Placebo/ Duration of Treatment: 156 weeks
4 Prevention of Colorectal Sporadic Adenomatous Polyps (PRESAP) Completed NCT00141193 Phase 3 Celecoxib
5 Celecoxib to Prevent Colorectal Cancer in Patients Who Have Undergone Surgery to Remove Polyps Completed NCT00005094 Phase 3 celecoxib
6 Aspirin in Treating Patients With Colorectal Cancer That Has Been Surgically Removed Completed NCT00002527 Phase 3 aspirin
7 Vitamin D/Calcium Polyp Prevention Study Completed NCT00153816 Phase 2, Phase 3 Calcium Carbonate;Vitamin D3;placebo
8 Aspirin/Folate Prevention of Large Bowel Polyps Completed NCT00272324 Phase 2, Phase 3 Aspirin;Folate
9 S0000D: Effect of Vitamin E and/or Selenium on Colorectal Polyps in Men Enrolled on SELECT Trial SWOG-S0000 Completed NCT00706121 Phase 3 Vitamin E;Selenium;Vitamin E placebo;selenium placebo
10 A Research of Berberine Hydrochloride to Prevent Colorectal Adenomas in Patients With Previous Colorectal Cancer Recruiting NCT03281096 Phase 2, Phase 3 Berberine hydrochloride;Placebo
11 Study of Calcium Plus Vitamin D Supplementation in Prevention of Colorectal Adenomas Recurrence Recruiting NCT02143505 Phase 2, Phase 3 Ca plus vit D
12 Effect of Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch Syndrome Recruiting NCT02813824 Phase 3 Acetylsalicylic acid lysinate 300 mg;Placebo (for Aspirin 300);Acetylsalicylic acid lysinate 100 mg;Placebo 100 (for Aspirin 100)
13 Primary Chemoprevention of Familial Adenomatous Polyposis With Berberine Hydrochloride Recruiting NCT03333265 Phase 2, Phase 3 100mg Berberine hydrochloride;300mg Berberine hydrochloride;Placebo Oral Tablet
14 Aspirin for Prevention of Postsurgical Recurrence and Metastasis in Asian Colorectal Cancer Patients: a Multi-center Randomized Trial Recruiting NCT02607072 Phase 3 Acetylsalicylic acid (ASA)/aspirin 200 mg daily;Acetylsalicylic acid (ASA)/aspirin 100 mg daily;Placebo
15 Study of Berberine Hydrochloride in Prevention of Colorectal Adenomas Recurrence Active, not recruiting NCT02226185 Phase 2, Phase 3 Berberine hydrochloride;placebo
16 Vitamin D and Omega-3 Trial (VITAL) Active, not recruiting NCT01169259 Phase 3 omega-3 fatty acids (fish oil)
17 Chemoprevention of Colorectal Adenomas Terminated NCT00486512 Phase 3 aspirin, 1,25-dihydroxycholecalciferol, calcium;placebo
18 Antioxidant Supplement and Reduction of Metachronous Adenomas of the Large Bowel: a Double Blind Randomized Trial Terminated NCT01437826 Phase 3 antioxidants;placebo
19 APACC Study:Prospective Study on Aspirin Efficacy in Reducing Colorectal Adenoma Recurrence Terminated NCT00224679 Phase 3 Aspirin
20 Selenium for Prevention of Adenomatous Colorectal Polyps Terminated NCT00078897 Phase 3 Selenium
21 Rosuvastatin in Treating Patients With Stage I or Stage II Colon Cancer That Was Removed By Surgery Terminated NCT01011478 Phase 3 rosuvastatin
22 Minimizing the Risk of Metachronous Adenomas of the Colorectum With Green Tea Extract -MIRACLE- Unknown status NCT01360320 Phase 2
23 Mesalazine Effects in Sporadic Colorectal Adenoma Patients Completed NCT01894685 Phase 2 Mesalazine;Placebo
24 Evaluation of Surgically Resected Colorectal Adenomas and Carcinomas After 7 Days Pretreatment With Celecoxib Completed NCT00582660 Phase 2 Celecoxib;Placebo
25 Trial of Metformin for Colorectal Cancer Risk Reduction for History of Colorectal Adenomas and Elevated BMI Completed NCT01312467 Phase 2 metformin hydrochloride
26 Study of the MUC1 Peptide-Poly-ICLC Adjuvant Vaccine in Individuals With Advanced Colorectal Adenoma Completed NCT00773097 Phase 2
27 Chemoprevention With Folic Acid Completed NCT00018551 Phase 2 Folic Acid
28 A Clinical Trial of COX and EGFR Inhibition in Familial Polyposis Patients Completed NCT01187901 Phase 2 Erlotinib;Sulindac;Placebo A;Placebo B
29 T Cell Receptor Immunotherapy Targeting HPV-16 E6 for HPV-Associated Cancers Completed NCT02280811 Phase 1, Phase 2 Fludarabine;Cyclophosphamide;Aldesleukin
30 Aspirin in Preventing Colorectal Cancer in Patients With Colorectal Adenoma Recruiting NCT02965703 Phase 2 Aspirin
31 A Randomized, 2x2 Factorial Design Biomarker Prevention Trial of Low-dose Aspirin and Metformin in Stage I-III Colorectal Cancer Patients. Recruiting NCT03047837 Phase 2 Aspirin (ASA) + Metformin (MET);ASA;MET;Placebos
32 Vaccine Therapy in Treating Patients With Newly Diagnosed Advanced Colon Polyps Active, not recruiting NCT02134925 Phase 2
33 Linaclotide in Treating Patients With Stages 0-3 Colorectal Cancer Not yet recruiting NCT03796884 Phase 2 Linaclotide
34 Polyphenon E in Treating Patients With High-Risk of Colorectal Cancer Terminated NCT01606124 Phase 2 defined green tea catechin extract
35 Celecoxib Window of Opportunity Trial to Assess Tumor and Stroma Responses Withdrawn NCT03185871 Phase 2 Celecoxib
36 Effect of Folate on Colon and Blood Cells Completed NCT00220012 Phase 1
37 Effect of Vitamin D and Calcium on Genes in the Colon Completed NCT00298545 Phase 1 placebo and Calcitriol;Calcium and Calcitriol
38 Detection of Colorectal Adenomas in Côte-d'Or Unknown status NCT02859714
39 Study of Prevalence of Colorectal Adenoma in 30- to 49-year-old Subjects With a Family History of Colorectal Cancer Unknown status NCT01428752
40 Comparison of Detection and Miss Rates of Blue Laser Imaging Versus Conventional White Light Colonoscopy Unknown status NCT02982447 Not Applicable
41 Detection of Colorectal Adenoma by Optical Enhancement Technology vs. High-Definition Colonoscopy Unknown status NCT02865382 Not Applicable
42 Effect of Single Colonoscopy on Colorectal Adenomas Detection Unknown status NCT02693886
43 Linked Color Imaging/Magnifying Blue Laser Imaging vs. White Light for Adenomas and Serrated Lesions in Proximal Colon Unknown status NCT02724397 Not Applicable
44 Aspirin and/or Folic Acid in Preventing Recurrent Colorectal Polyps Unknown status NCT00033319 Not Applicable acetylsalicylic acid
45 Endoscopic Full Thickness Resection in the Lower GI Tract With the "Full Thickness Resection Device" Unknown status NCT02362126
46 Intubation Techniques on Colonoscopy Quality (SINOCOLO2013) Unknown status NCT01919463 Not Applicable
47 Endocuff Adenoma Detection Rate Pilot Study Unknown status NCT01761097 Not Applicable
48 Adenoma Detection by Polypectomy During Both Insertion and Withdrawal Unknown status NCT01925833 Not Applicable
49 Effect of Water Exchange Method on Adenoma Miss Rates in Patients Undergoing Selective Polypectomy Unknown status NCT02880748 Not Applicable
50 Impact of DietarY and LIfestyle Risk Factors on Colorectal Cancer Screening Unknown status NCT02804802

Search NIH Clinical Center for Colorectal Adenoma

Genetic Tests for Colorectal Adenoma

Genetic tests related to Colorectal Adenoma:

# Genetic test Affiliating Genes
1 Colorectal Adenoma 29

Anatomical Context for Colorectal Adenoma

MalaCards organs/tissues related to Colorectal Adenoma:

41
Colon, Liver, T Cells, Bone, Prostate, Lung, Breast

Publications for Colorectal Adenoma

Articles related to Colorectal Adenoma:

(show top 50) (show all 739)
# Title Authors Year
1
Family history of colorectal cancer in first-degree relatives and metachronous colorectal adenoma. ( 29463834 )
2018
2
Associations of Circulating 25-Hydroxyvitamin D3 Concentrations With Incident, Sporadic Colorectal Adenoma Risk According to Common Vitamin D Binding Protein Isoforms. ( 29788105 )
2018
3
Left-Sided Colectomy: One of the Important Risk Factors of Metachronous Colorectal Adenoma After Colectomy for Colon Cancer. ( 29417332 )
2018
4
Histopathologic Features of Colorectal Adenoma and Adenocarcinoma Developing Within Inflammatory Polyps in Miniature Dachshunds. ( 29852840 )
2018
5
Age and gender may be the key points in hyperglycemic patients with Helicobacter pylori infection combined colorectal adenoma-author's reply. ( 29644785 )
2018
6
Associations of mitochondrial polymorphisms with sporadic colorectal adenoma. ( 29323753 )
2018
7
Association between investigator-measured body-mass index and colorectal adenoma: a systematic review and meta-analysis of 168,201 subjects. ( 29288474 )
2018
8
Age and gender may be the key points in hyperglycemic patients with Helicobacter pylori infection combined colorectal adenoma. ( 29480547 )
2018
9
Different effects of metformin and insulin on primary and secondary chemoprevention of colorectal adenoma in diabetes type 2: Traditional and Bayesian meta-analysis. ( 29383018 )
2018
10
The Fatty Liver Index: A Simple and Accurate Predictor of Colorectal Adenoma in an Average-Risk Population. ( 29219920 )
2018
11
Colorectal Adenoma Risk Is Increased among Recently Diagnosed Adult Celiac Disease Patients. ( 29849594 )
2018
12
Meat Mutagens and Colorectal Adenoma and Cancer: A Problem with a Recently Published Systematic Review and Meta-Analysis. ( 29509700 )
2018
13
Impaired Secretion of Glucagon-Like Peptide 1 in Patients with Colorectal Adenoma after an Oral Glucose Load. ( 29539609 )
2018
14
A Novel Application of Structural Equation Modeling Estimates the Association between Oxidative Stress and Colorectal Adenoma. ( 29074536 )
2018
15
The study of bacteria in biopsies from Slovak colorectal adenoma and carcinoma patients. ( 29940777 )
2018
16
Identification of Kininogen 1 as a Serum Protein Marker of Colorectal Adenoma in Patients with a Family History of Colorectal Cancer. ( 29535795 )
2018
17
Visceral obesity as a risk factor for colorectal adenoma occurrence in surveillance colonoscopy. ( 29510147 )
2018
18
Resting heart rate is an independent predictor of advanced colorectal adenoma recurrence. ( 29499053 )
2018
19
Polymorphisms in genes related to inflammation and obesity and colorectal adenoma risk. ( 29802748 )
2018
20
Colorectal adenoma risk in childhood cancer survivors. ( 29526391 )
2018
21
Predictors of High-Risk Adenoma Occurrence at Surveillance Colonoscopy in Patients Who Undergo Colorectal Adenoma Removal. ( 29969782 )
2018
22
Hotspot <i>KRAS</i> exon 2 mutations in CD166 positive colorectal cancer and colorectal adenoma cells. ( 29755662 )
2018
23
Age at menarche and risk of colorectal adenoma. ( 29843495 )
2018
24
Discovery and Validation of Circulating Biomarkers of Colorectal Adenoma by High-Depth Small RNA Sequencing. ( 29490987 )
2018
25
Adiponectin, Leptin, IGF-1, and Tumor Necrosis Factor Alpha As Potential Serum Biomarkers for Non-Invasive Diagnosis of Colorectal Adenoma in African Americans. ( 29593647 )
2018
26
Global and targeted circulating microRNA profiling of colorectal adenoma and colorectal cancer. ( 29112225 )
2018
27
Bioinformatics Analysis Reveals Most Prominent Gene Candidates to Distinguish Colorectal Adenoma from Adenocarcinoma. ( 30175151 )
2018
28
Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer. ( 30469315 )
2018
29
Effects of vitamin D and calcium on expression of MSH2 and transforming growth factors in normal-appearing colorectal mucosa of sporadic colorectal adenoma patients: a randomized clinical trial. ( 30499618 )
2018
30
Upregulation of Fibroblast Growth Factor 19 Is Associated with the Initiation of Colorectal Adenoma. ( 30517925 )
2018
31
Effects of supplemental vitamin D and calcium on markers of proliferation, differentiation, and apoptosis in the normal colorectal mucosa of colorectal adenoma patients. ( 30557404 )
2018
32
Dietary Heterocyclic Amine Intake and Colorectal Adenoma Risk: A Systematic Review and Meta-Analysis. ( 30275115 )
2018
33
Telomere length in the colon is related to colorectal adenoma prevalence. ( 30332457 )
2018
34
Associations of Nut Intakes with Incident Sporadic Colorectal Adenoma: A Pooled Case-Control Study. ( 30372131 )
2018
35
Comparison of Pre- and Post-translational Expressions of COXIV-1 and MT-ATPase 6 Genes in Colorectal Adenoma-Carcinoma Tissues. ( 30393577 )
2018
36
Association of visceral adiposity and insulin resistance with colorectal adenoma and colorectal cancer. ( 30419640 )
2018
37
miR-212 and mTOR form a regulation loop to modulate autophagy in colorectal adenoma HT-29 cells. ( 30021100 )
2018
38
Adherence to Nutrition and Physical Activity Cancer Prevention Guidelines and Development of Colorectal Adenoma. ( 30115827 )
2018
39
Vitamin D receptor FokI polymorphism and the risks of colorectal cancer, inflammatory bowel disease, and colorectal adenoma. ( 30150667 )
2018
40
Differences in risk factor-colorectal adenoma associations according to non-steroidal anti-inflammatory drug use. ( 30161027 )
2018
41
Association between red and processed meat intake and colorectal adenoma incidence and recurrence: a systematic review and meta-analysis. ( 30190793 )
2018
42
Effects of Supplemental Calcium and Vitamin D on Expression of Toll-Like Receptors and Phospho-IKKα/β in the Normal Rectal Mucosa of Colorectal Adenoma Patients. ( 30209117 )
2018
43
Association between oral health and colorectal adenoma in a screening population. ( 30212957 )
2018
44
Hepatitis B Virus Infection Is Independently Associated With Advanced Colorectal Adenoma. ( 30219156 )
2018
45
The somatic mutation landscape of premalignant colorectal adenoma. ( 28607096 )
2018
46
Feasibility of CYFRA 21-1 as a serum biomarker for the detection of colorectal adenoma and advanced colorectal adenoma in people over the age of 45. ( 28186354 )
2018
47
Differential Expression of Cytochrome C Oxidase Subunit I Along the Colorectal Adenoma: Carcinoma Progression. ( 28362707 )
2018
48
Long-term use of antibiotics and risk of colorectal adenoma. ( 28377387 )
2018
49
Gallbladder stones and gallbladder polyps associated with increased risk of colorectal adenoma in men. ( 28971517 )
2017
50
Expression of circadian clock genes in human colorectal adenoma and carcinoma. ( 29113166 )
2017

Variations for Colorectal Adenoma

ClinVar genetic disease variations for Colorectal Adenoma:

6 (show all 26)
# Gene Variation Type Significance SNP ID Assembly Location
1 APC NM_000038.5(APC): c.3479C> A (p.Thr1160Lys) single nucleotide variant Conflicting interpretations of pathogenicity rs201004111 GRCh37 Chromosome 5, 112174770: 112174770
2 APC NM_000038.5(APC): c.3479C> A (p.Thr1160Lys) single nucleotide variant Conflicting interpretations of pathogenicity rs201004111 GRCh38 Chromosome 5, 112839073: 112839073
3 APC NM_000038.5(APC): c.7717A> G (p.Ile2573Val) single nucleotide variant Conflicting interpretations of pathogenicity rs145444830 GRCh37 Chromosome 5, 112179008: 112179008
4 APC NM_000038.5(APC): c.7717A> G (p.Ile2573Val) single nucleotide variant Conflicting interpretations of pathogenicity rs145444830 GRCh38 Chromosome 5, 112843311: 112843311
5 APC NM_000038.5(APC): c.4336G> A (p.Ala1446Thr) single nucleotide variant Likely benign rs146572883 GRCh38 Chromosome 5, 112839930: 112839930
6 APC NM_000038.5(APC): c.4336G> A (p.Ala1446Thr) single nucleotide variant Likely benign rs146572883 GRCh37 Chromosome 5, 112175627: 112175627
7 APC NM_000038.5(APC): c.4360A> G (p.Lys1454Glu) single nucleotide variant Conflicting interpretations of pathogenicity rs111866410 GRCh38 Chromosome 5, 112839954: 112839954
8 APC NM_000038.5(APC): c.4360A> G (p.Lys1454Glu) single nucleotide variant Conflicting interpretations of pathogenicity rs111866410 GRCh37 Chromosome 5, 112175651: 112175651
9 APC NM_000038.5(APC): c.4237A> G (p.Met1413Val) single nucleotide variant Conflicting interpretations of pathogenicity rs141519952 GRCh37 Chromosome 5, 112175528: 112175528
10 APC NM_000038.5(APC): c.4237A> G (p.Met1413Val) single nucleotide variant Conflicting interpretations of pathogenicity rs141519952 GRCh38 Chromosome 5, 112839831: 112839831
11 APC NM_000038.5(APC): c.4420G> A (p.Ala1474Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs139387758 GRCh37 Chromosome 5, 112175711: 112175711
12 APC NM_000038.5(APC): c.4420G> A (p.Ala1474Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs139387758 GRCh38 Chromosome 5, 112840014: 112840014
13 APC NM_000038.5(APC): c.6985A> G (p.Ile2329Val) single nucleotide variant Benign/Likely benign rs146048493 GRCh38 Chromosome 5, 112842579: 112842579
14 APC NM_000038.5(APC): c.6985A> G (p.Ile2329Val) single nucleotide variant Benign/Likely benign rs146048493 GRCh37 Chromosome 5, 112178276: 112178276
15 APC NM_000038.5(APC): c.8266A> G (p.Ile2756Val) single nucleotide variant Conflicting interpretations of pathogenicity rs146115809 GRCh38 Chromosome 5, 112843860: 112843860
16 APC NM_000038.5(APC): c.8266A> G (p.Ile2756Val) single nucleotide variant Conflicting interpretations of pathogenicity rs146115809 GRCh37 Chromosome 5, 112179557: 112179557
17 APC NM_000038.5(APC): c.4732T> G (p.Cys1578Gly) single nucleotide variant Conflicting interpretations of pathogenicity rs138367627 GRCh37 Chromosome 5, 112176023: 112176023
18 APC NM_000038.5(APC): c.4732T> G (p.Cys1578Gly) single nucleotide variant Conflicting interpretations of pathogenicity rs138367627 GRCh38 Chromosome 5, 112840326: 112840326
19 APC NM_000038.5(APC): c.8383G> A (p.Ala2795Thr) single nucleotide variant Uncertain significance rs369264968 GRCh37 Chromosome 5, 112179674: 112179674
20 APC NM_000038.5(APC): c.8383G> A (p.Ala2795Thr) single nucleotide variant Uncertain significance rs369264968 GRCh38 Chromosome 5, 112843977: 112843977
21 APC NM_000038.5(APC): c.449A> G (p.Lys150Arg) single nucleotide variant Uncertain significance rs371085910 GRCh37 Chromosome 5, 112111352: 112111352
22 APC NM_000038.5(APC): c.449A> G (p.Lys150Arg) single nucleotide variant Uncertain significance rs371085910 GRCh38 Chromosome 5, 112775655: 112775655
23 APC NM_000038.5(APC): c.2847G> T (p.Met949Ile) single nucleotide variant Conflicting interpretations of pathogenicity rs147394539 GRCh37 Chromosome 5, 112174138: 112174138
24 APC NM_000038.5(APC): c.2847G> T (p.Met949Ile) single nucleotide variant Conflicting interpretations of pathogenicity rs147394539 GRCh38 Chromosome 5, 112838441: 112838441
25 APC NM_000038.5(APC): c.7778A> G (p.Asn2593Ser) single nucleotide variant Uncertain significance rs367676584 GRCh37 Chromosome 5, 112179069: 112179069
26 APC NM_000038.5(APC): c.7778A> G (p.Asn2593Ser) single nucleotide variant Uncertain significance rs367676584 GRCh38 Chromosome 5, 112843372: 112843372

Expression for Colorectal Adenoma

LifeMap Discovery
Genes differentially expressed in tissues of Colorectal Adenoma patients vs. healthy controls: 35 (show top 50) (show all 255)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 GCG glucagon Colon - 9.14 0.000
2 GUCA2B guanylate cyclase activator 2B (uroguanylin) Colon - 8.78 0.000
3 MS4A12 membrane-spanning 4-domains, subfamily A, member 12 Colon - 8.78 0.000
4 AQP8 aquaporin 8 Colon - 8.30 0.000
5 CA1 carbonic anhydrase I Colon - 8.11 0.000
6 CLCA4 chloride channel accessory 4 Colon - 7.63 0.000
7 CA4 carbonic anhydrase IV Colon - 7.51 0.000
8 TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) Colon + 7.34 0.000
9 CLDN8 claudin 8 Colon - 7.18 0.000
10 CDH3 cadherin 3, type 1, P-cadherin (placental) Colon + 6.97 0.000
11 GUCA2A guanylate cyclase activator 2A (guanylin) Colon - 6.92 0.000
12 HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 Colon - 6.85 0.001
13 PRAC1 prostate cancer susceptibility candidate 1 Colon - 6.72 0.040
14 CEMIP cell migration inducing protein, hyaluronan binding Colon + 6.69 0.000
15 INSL5 insulin-like 5 Colon - 6.67 0.000
16 PYY peptide YY Colon - 6.57 0.000
17 SCNN1B sodium channel, non voltage gated 1 beta subunit Colon - 6.53 0.000
18 CHGA chromogranin A Colon - 6.30 0.000
19 SST somatostatin Colon - 5.99 0.000
20 ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) Colon - 5.77 0.002
21 SLC51B solute carrier family 51, beta subunit Colon - 5.54 0.001
22 CD177 CD177 molecule Colon - 5.52 0.003
23 GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) Colon - 5.48 0.000
24 SLC25A34 solute carrier family 25, member 34 Colon - 5.43 0.000
25 SLC26A3 solute carrier family 26 (anion exchanger), member 3 Colon - 5.39 0.002
26 CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) Colon - 5.35 0.000
27 ZG16 zymogen granule protein 16 Colon - 5.34 0.000
28 MSX2 msh homeobox 2 Colon + 5.31 0.000
29 FABP6 fatty acid binding protein 6, ileal Colon + 5.29 0.000
30 EPHX4 epoxide hydrolase 4 Colon + 5.24 0.000
31 DUSP27 dual specificity phosphatase 27 (putative) Colon + 5.23 0.000
32 TACSTD2 tumor-associated calcium signal transducer 2 Colon + 5.10 0.000
33 GABRP gamma-aminobutyric acid (GABA) A receptor, pi Colon + 5.08 0.003
34 BEST4 bestrophin 4 Colon - 5.08 0.001
35 S100A2 S100 calcium binding protein A2 Colon + 5.05 0.000
36 DPEP1 dipeptidase 1 (renal) Colon + 5.04 0.010
37 MUC12 mucin 12, cell surface associated Colon - 4.98 0.020
38 SPINK5 serine peptidase inhibitor, Kazal type 5 Colon - 4.96 0.001
39 PCSK1 proprotein convertase subtilisin/kexin type 1 Colon + 4.92 0.008
40 SLC30A10 solute carrier family 30, member 10 Colon - 4.89 0.003
41 TMEM72 transmembrane protein 72 Colon - 4.88 0.000
42 KLK10 kallikrein-related peptidase 10 Colon + 4.85 0.020
43 CDH19 cadherin 19, type 2 Colon - 4.83 0.001
44 CDKN2B-AS1 CDKN2B antisense RNA 1 Colon - 4.75 0.004
45 MT1M metallothionein 1M Colon - 4.75 0.027
46 SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 Colon - 4.71 0.007
47 PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) Colon - 4.70 0.000
48 ANO5 anoctamin 5 Colon - 4.68 0.000
49 FOXQ1 forkhead box Q1 Colon + 4.62 0.000
50 CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 Colon - 4.60 0.001
Search GEO for disease gene expression data for Colorectal Adenoma.

Pathways for Colorectal Adenoma

Pathways related to Colorectal Adenoma according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 APC CTNNB1 HRAS IGF1 KRAS PTGS2
2
Show member pathways
12.89 HRAS KRAS MLH1 MSH2 PTGS2 TP53
3
Show member pathways
12.67 APC CTNNB1 HRAS IGF1 KRAS MLH1
4
Show member pathways
12.66 APC CTNNB1 HRAS KRAS PTGS2 TP53
5
Show member pathways
12.64 APC CTNNB1 HRAS IGF1 KRAS MLH1
6
Show member pathways
12.56 CTNNB1 HRAS KRAS MSH2 TP53
7 12.48 APC HRAS KRAS PTGS2 TP53
8
Show member pathways
12.46 APC HRAS IGF1 KRAS TP53
9
Show member pathways
12.41 CTNNB1 HRAS KRAS TP53
10 12.39 APC CTNNB1 PTGS2 TP53
11
Show member pathways
12.39 APC CTNNB1 HRAS KRAS
12
Show member pathways
12.37 CTNNB1 HRAS KRAS PTGS2
13
Show member pathways
12.37 APC CTNNB1 HRAS IGF1 KRAS
14 12.37 APC CTNNB1 HRAS KRAS TP53
15
Show member pathways
12.36 HRAS IGF1 IGFBP3 TP53
16 12.33 APC CTNNB1 HRAS IGF1 KRAS MLH1
17
Show member pathways
12.27 CRP MTHFR MTR PTGS2 TP53
18 12.21 CTNNB1 HRAS IGF1 KRAS TP53
19 12.15 HRAS IGFBP3 KRAS TP53
20
Show member pathways
12.1 HRAS IGF1 KRAS TP53
21 12.06 CTNNB1 KRAS MSH2 ODC1 TP53
22 12 APC CTNNB1 HRAS IGF1 KRAS
23 11.98 APC CTNNB1 HRAS KRAS
24 11.95 CTNNB1 HRAS KRAS TP53
25 11.9 HRAS IGF1 IGFBP3 TP53
26 11.86 APC CTNNB1 HRAS KRAS TP53
27 11.85 APC IGFBP3 MLH1 MSH2 TP53 VDR
28 11.71 HRAS KRAS TP53
29 11.71 MLH1 MSH2 TP53
30 11.68 APC CTNNB1 HRAS IGF1 KRAS TP53
31 11.65 HRAS KRAS TP53
32 11.65 HRAS KRAS TP53
33 11.61 HRAS IGF1 KRAS
34 11.59 CTNNB1 IGFBP3 PTGS2
35 11.5 HRAS KRAS PTGS2
36 11.49 HRAS KRAS MLH1 MSH2 TP53
37
Show member pathways
11.45 MLH1 MSH2 NAT1
38
Show member pathways
11.4 MLH1 MSH2 TP53
39 11.38 APC CTNNB1 KRAS MLH1 MSH2 PTGS2
40 11.36 IGFBP3 PTGS2 TP53
41 11.28 HRAS KRAS TP53
42
Show member pathways
11.15 HRAS IGF1 KRAS
43 11.15 APC CTNNB1 HRAS KRAS
44 10.8 HRAS KRAS

GO Terms for Colorectal Adenoma

Cellular components related to Colorectal Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 9.32 MLH1 MSH2
2 beta-catenin destruction complex GO:0030877 9.26 APC CTNNB1
3 Wnt signalosome GO:1990909 9.16 APC CTNNB1
4 insulin-like growth factor ternary complex GO:0042567 8.96 IGF1 IGFBP3
5 insulin-like growth factor binding protein complex GO:0016942 8.62 IGF1 IGFBP3

Biological processes related to Colorectal Adenoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.92 APC MLH1 MSH2 MUTYH TP53
2 positive regulation of apoptotic process GO:0043065 9.88 APC CTNNB1 IGFBP3 PTGS2 TP53
3 positive regulation of cell proliferation GO:0008284 9.85 CTNNB1 HRAS IGF1 KRAS ODC1 PTGS2
4 cell cycle arrest GO:0007050 9.73 APC HRAS MSH2 TP53
5 positive regulation of MAPK cascade GO:0043410 9.71 CTNNB1 HRAS IGF1 IGFBP3
6 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.57 IGF1 IGFBP3
7 methionine biosynthetic process GO:0009086 9.56 MTHFR MTR
8 negative regulation of blood vessel diameter GO:0097756 9.55 CRP PTGS2
9 positive regulation of isotype switching to IgG isotypes GO:0048304 9.54 MLH1 MSH2
10 response to isolation stress GO:0035900 9.51 HRAS KRAS
11 mismatch repair GO:0006298 9.5 MLH1 MSH2 MUTYH
12 negative regulation of cell proliferation GO:0008285 9.5 APC CTNNB1 HRAS IGFBP3 PTGS2 TP53
13 positive regulation of isotype switching to IgA isotypes GO:0048298 9.49 MLH1 MSH2
14 somatic recombination of immunoglobulin gene segments GO:0016447 9.46 MLH1 MSH2
15 Ras protein signal transduction GO:0007265 9.46 HRAS IGF1 KRAS TP53
16 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.26 MLH1 MSH2
17 positive regulation of gene expression GO:0010628 9.17 CRP CTNNB1 HRAS IGF1 KRAS TP53

Molecular functions related to Colorectal Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 9.37 MLH1 MSH2
2 MutLalpha complex binding GO:0032405 9.32 MSH2 MUTYH
3 MutSalpha complex binding GO:0032407 9.26 MLH1 MUTYH
4 oxidized purine DNA binding GO:0032357 9.16 MSH2 MUTYH
5 enzyme binding GO:0019899 9.02 CTNNB1 MLH1 MSH2 PTGS2 TP53
6 guanine/thymine mispair binding GO:0032137 8.96 MLH1 MSH2

Sources for Colorectal Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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