MCID: CLR108
MIFTS: 64

Colorectal Adenoma

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases

Aliases & Classifications for Colorectal Adenoma

MalaCards integrated aliases for Colorectal Adenoma:

Name: Colorectal Adenoma 12 29 6 15 17
Adenoma of Large Intestine 72
Colorectal Adenomas 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050860
UMLS 72 C1302401

Summaries for Colorectal Adenoma

Disease Ontology : 12 An intestinal benign neoplasm that has material basis in epithelial tissue of glandular origin and is located in colon and located in rectum.

MalaCards based summary : Colorectal Adenoma, also known as adenoma of large intestine, is related to mutyh-associated polyposis and polyposis syndrome, hereditary mixed, 1. An important gene associated with Colorectal Adenoma is APC (APC Regulator Of WNT Signaling Pathway), and among its related pathways/superpathways are fMLP Pathway and PI3K-Akt signaling pathway. The drugs Anesthetics and Calcium carbonate have been mentioned in the context of this disorder. Affiliated tissues include colon, rectum and colon, and related phenotypes are Increased shRNA abundance and Reduced mammosphere formation

Wikipedia : 75 The colorectal adenoma is a benign glandular tumor of the colon and the rectum. It is a precursor lesion... more...

Related Diseases for Colorectal Adenoma

Diseases related to Colorectal Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 274)
# Related Disease Score Top Affiliating Genes
1 mutyh-associated polyposis 33.5 TP53 MUTYH KRAS APC
2 polyposis syndrome, hereditary mixed, 1 33.3 PTGS2 MUTYH MLH1 GREM1 APC
3 mismatch repair cancer syndrome 33.0 MSH2 MLH1 CTNNB1 APC
4 colon adenoma 31.7 VDR KRAS APC
5 attenuated familial adenomatous polyposis 31.0 MUTYH MSH2 APC
6 adenoma 30.9 TP53 PTGS2 MUTYH MSH2 MLH1 KRAS
7 juvenile polyposis syndrome 30.7 PTGS2 MUTYH APC
8 familial adenomatous polyposis 1 30.7 CTNNB1 APC
9 peutz-jeghers syndrome 30.6 TP53 CTNNB1 APC
10 hyperplastic polyposis syndrome 30.5 TP53 MUTYH KRAS APC
11 hepatoblastoma 30.3 TP53 CTNNB1 APC
12 adenocarcinoma 29.9 TP53 PTGS2 MLH1 KRAS HRAS CTNNB1
13 familial adenomatous polyposis 29.8 TP53 PTGS2 MUTYH MSH2 MLH1 KRAS
14 colon adenocarcinoma 29.8 PTGS2 MLH1 KRAS CTNNB1 CDH1 APC
15 myeloma, multiple 29.4 TP53 KRAS IGF1 HRAS
16 ovarian cancer 29.4 TP53 MSH2 MLH1 KRAS CTNNB1 CDH1
17 familial colorectal cancer 29.2 TP53 MUTYH MSH2 MLH1 GREM1 CDH1
18 lynch syndrome 29.1 TP53 MUTYH MSH2 MLH1 MGMT KRAS
19 colorectal adenocarcinoma 29.0 TP53 PTGS2 MSH2 MLH1 KRAS HRAS
20 esophageal cancer 28.5 TP53 PTGS2 KRAS HRAS GSTM1 CTNNB1
21 cervical cancer 28.4 TP53 PTGS2 IGFBP3 HRAS GSTM1 CTNNB1
22 gastrointestinal system disease 28.0 TP53 PTGS2 MSH2 MLH1 KRAS HRAS
23 endometrial cancer 27.8 TP53 MUTYH MSH2 MLH1 KRAS IGF1
24 prostate cancer 27.7 VDR TP53 PTGS2 KRAS IGFBP3 IGF1
25 gastric adenocarcinoma 27.3 TP53 PTGS2 MLH1 MGMT KRAS HRAS
26 breast cancer 27.2 TP53 PTGS2 MSH2 MLH1 KRAS IGFBP3
27 gastric cancer 27.2 TP53 PTGS2 MUTYH MTHFR MSH2 MLH1
28 colorectal cancer 25.6 VDR TP53 SFRP2 PTGS2 MUTYH MTHFR
29 large intestine cancer 25.4 VDR TP53 SFRP2 PTGS2 MUTYH MTHFR
30 familial adenomatous polyposis 2 12.2
31 colorectal cancer 1 11.9
32 colorectal cancer 12 11.8
33 desmoid disease, hereditary 10.8 CTNNB1 APC
34 adult hepatocellular carcinoma 10.7 TP53 CTNNB1
35 hereditary mixed polyposis syndrome 10.7 PTGS2 GREM1
36 rare adenocarcinoma of the breast 10.7 TP53 KRAS
37 barrett's adenocarcinoma 10.6 TP53 PTGS2 KRAS
38 colonic benign neoplasm 10.6 PTGS2 KRAS CTNNB1
39 homocystinuria due to deficiency of n -methylenetetrahydrofolate reductase activity 10.6 MTR MTHFR
40 anal squamous cell carcinoma 10.6 TP53 MLH1 APC
41 colorectal cancer 2 10.6 MLH1 GSTM1
42 ureteral obstruction 10.6 TP53 PTGS2 CTNNB1
43 cardia cancer 10.6 TP53 MTHFR GSTM1
44 protoplasmic astrocytoma 10.6 TP53 PTGS2
45 slipped capital femoral epiphysis 10.5 IGFBP3 IGF1
46 villous adenoma 10.5
47 body mass index quantitative trait locus 1 10.5
48 cerebral convexity meningioma 10.4 TP53 CDH1
49 in situ carcinoma 10.4
50 secondary adrenal insufficiency 10.4 IGFBP3 IGF1

Graphical network of the top 20 diseases related to Colorectal Adenoma:



Diseases related to Colorectal Adenoma

Symptoms & Phenotypes for Colorectal Adenoma

GenomeRNAi Phenotypes related to Colorectal Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 9.35 APC MLH1 MTHFR MTR MUTYH
2 Reduced mammosphere formation GR00396-S 9.23 CDH1 GSTM1 HRAS IGF1 IGFBP3 KRAS

MGI Mouse Phenotypes related to Colorectal Adenoma:

46 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.53 APC CDH1 CTNNB1 EPHX1 GREM1 HRAS
2 cellular MP:0005384 10.42 APC CDH1 CTNNB1 GREM1 IGF1 KRAS
3 mortality/aging MP:0010768 10.42 APC CDH1 CTNNB1 GREM1 HRAS IGF1
4 endocrine/exocrine gland MP:0005379 10.39 APC CDH1 CTNNB1 HRAS IGF1 IGFBP3
5 growth/size/body region MP:0005378 10.38 APC CDH1 CTNNB1 GREM1 HRAS IGF1
6 integument MP:0010771 10.35 APC CDH1 CTNNB1 HRAS IGF1 IGFBP3
7 cardiovascular system MP:0005385 10.31 APC CDH1 CTNNB1 HRAS IGF1 KRAS
8 digestive/alimentary MP:0005381 10.29 APC CDH1 CTNNB1 HRAS KRAS MLH1
9 neoplasm MP:0002006 10.27 APC CDH1 CTNNB1 EPHX1 HRAS IGF1
10 nervous system MP:0003631 10.25 APC CTNNB1 GREM1 HRAS IGF1 KRAS
11 limbs/digits/tail MP:0005371 10.22 APC CTNNB1 GREM1 IGF1 IGFBP3 KRAS
12 embryo MP:0005380 10.19 APC CDH1 CTNNB1 GREM1 KRAS PTGS2
13 craniofacial MP:0005382 10.14 APC CTNNB1 HRAS KRAS SFRP2 TP53
14 muscle MP:0005369 10.13 APC CTNNB1 IGF1 IGFBP3 KRAS PTGS2
15 no phenotypic analysis MP:0003012 10.06 CDH1 CTNNB1 HRAS KRAS MGMT MTHFR
16 liver/biliary system MP:0005370 10.05 APC CTNNB1 IGFBP3 KRAS MTHFR PTGS2
17 hearing/vestibular/ear MP:0005377 10.03 APC CTNNB1 IGF1 KRAS TP53 VDR
18 normal MP:0002873 10.02 APC CDH1 CTNNB1 HRAS IGF1 KRAS
19 reproductive system MP:0005389 9.93 APC CDH1 CTNNB1 GREM1 IGF1 KRAS
20 renal/urinary system MP:0005367 9.91 APC CTNNB1 GREM1 HRAS IGF1 KRAS
21 pigmentation MP:0001186 9.72 APC CTNNB1 IGFBP3 KRAS TP53
22 respiratory system MP:0005388 9.61 CTNNB1 GREM1 HRAS IGF1 KRAS MGMT
23 skeleton MP:0005390 9.4 APC CTNNB1 GREM1 HRAS IGF1 IGFBP3

Drugs & Therapeutics for Colorectal Adenoma

Drugs for Colorectal Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 115)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics Phase 4
2
Calcium carbonate Approved, Investigational Phase 3 471-34-1
3
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
4
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
5
Tocopherol Approved, Investigational Phase 3 1406-66-2, 54-28-4 14986
6
Zinc Approved, Investigational Phase 3 7440-66-6 32051
7
Vitamin D3 Approved, Nutraceutical Phase 3 67-97-0 6221 5280795
8
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
9
Calcitriol Approved, Nutraceutical Phase 3 32222-06-3 5280453 134070
10
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
11
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 22737-96-8, 11103-57-4, 68-26-8 9904001 445354
12
Vitamin C Approved, Nutraceutical Phase 3 50-81-7 54670067 5785
13 Tocotrienol Investigational Phase 3 6829-55-6
14 Omega 3 Fatty Acid Phase 2, Phase 3
15 Analgesics Phase 3
16 Anti-Inflammatory Agents Phase 3
17 Cyclooxygenase Inhibitors Phase 3
18 Peripheral Nervous System Agents Phase 3
19 Analgesics, Non-Narcotic Phase 3
20 Anti-Inflammatory Agents, Non-Steroidal Phase 3
21 Antirheumatic Agents Phase 3
22 Acetylsalicylic acid lysinate Phase 3
23 Trace Elements Phase 3
24 Micronutrients Phase 3
25 Hormones Phase 3
26 Vitamins Phase 3
27 Nutrients Phase 3
28 Calciferol Phase 3
29 Calcium, Dietary Phase 3
30 Bone Density Conservation Agents Phase 3
31 Gastrointestinal Agents Phase 3
32 Cola Phase 3
33 Fibrinolytic Agents Phase 3
34 Platelet Aggregation Inhibitors Phase 3
35 Antipyretics Phase 3
36 Antacids Phase 3
37 Dihydroxycholecalciferols Phase 3
38 Anti-Ulcer Agents Phase 3
39 Vasoconstrictor Agents Phase 3
40 Antioxidants Phase 3
41 Tocotrienols Phase 3
42 Tocopherols Phase 3
43 Protective Agents Phase 3
44 Lipid Regulating Agents Phase 3
45 Rosuvastatin Calcium Phase 3 147098-20-2
46 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
47 Hypolipidemic Agents Phase 3
48 Anticholesteremic Agents Phase 3
49 Antimetabolites Phase 3
50 retinol Phase 3

Interventional clinical trials:

(show top 50) (show all 112)
# Name Status NCT ID Phase Drugs
1 Efficacy and Cost-effectiveness of Colonoscopy vs. Combined Fecal Immunochemical Test-Sigmoidoscopy for the Detection of Advanced Colorectal Neoplasia (eCOLO-FITS): A Randomized Multicenter Trial Unknown status NCT01767870 Phase 4
2 Transanal Endoscopic Microsurgery Versus Endoscopic Submucosal Dissection For Large Rectal Adenomas Suspended NCT01023984 Phase 4
3 Calcium Plus Vitamin D Supplementation in Prevention of Colorectal Adenomas Recurrence:a Prospective, Randomized, Placebo-controlled, Multicenter Clinical Trial Unknown status NCT02143505 Phase 2, Phase 3 Ca plus vit D
4 A Randomize Controlled Trial of Folic Acid, Calcium and Vitamin D in Preventing Colorectal Polyps and Colorectal Cancer Unknown status NCT02066688 Phase 2, Phase 3 folic acid;folic acid calcium vitamin D3;calcium
5 A Randomized, Placebo-controlled, Multicenter, Prospective Clinical Study of Berberine Hydrochloride in Preventing Recurrence and Carcinogenesis After Endoscopic Removal of Colorectal Adenomas Completed NCT02226185 Phase 2, Phase 3 Berberine hydrochloride;placebo
6 A Multicenter, Randomized, Parallel-Group, Placebo-Controlled, Double-Blind Study With In-House Blinding to Determine the Effect of 156 Weeks of Treatment With MK0966 on the Recurrence of Neoplastic Polyps of the Large Bowel in Patients With a History of Colorectal Adenomas Completed NCT00282386 Phase 3 MK0966; Rofecoxib / Duration of Treatment: 156 weeks;Placebo/ Duration of Treatment: 156 weeks
7 Clinical Protocol For a Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of Celecoxib (SC-58635) In The Prevention of Colorectal Sporadic Adenomatous Polyps (PRESAP) Completed NCT00141193 Phase 3 Celecoxib
8 S0000D: A Study of the Effect of Vitamin E and/or Selenium on Adenomatous Colorectal Polyps (ACP) in Participants Enrolled in SELECT Completed NCT00706121 Phase 3 Vitamin E;Selenium;Vitamin E placebo;selenium placebo
9 Prevention of Sporadic Colorectal Adenomas With Celecoxib Completed NCT00005094 Phase 3 celecoxib
10 Colorectal Adenoma Chemoprevention Trial Using Aspirin: A Phase III Study Completed NCT00002527 Phase 3 aspirin
11 A Two-Arm Chemoprevention Trial in Familial Adenomatous Polyposis (FAP) Coli Patients Using the Purified Free Fatty Acid, Eicosapentaenoic Acid Completed NCT00510692 Phase 2, Phase 3 Eicosapentanoic Acid (EPA);Placebo
12 Assessment of the Effect of a Daily Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch Syndrome Recruiting NCT02813824 Phase 3 Acetylsalicylic acid lysinate 300 mg;Placebo (for Aspirin 300);Acetylsalicylic acid lysinate 100 mg;Placebo 100 (for Aspirin 100)
13 A Randomized Trial of Berberine Hydrochloride to Prevent Colorectal Adenomas in Patients With Previous Colorectal Cancer Recruiting NCT03281096 Phase 2, Phase 3 Berberine hydrochloride;Placebo
14 The Effect of Berberine Hydrochloride in Familial Adenomatous Polyposis:a Prospective, Randomized, Double Blind, Placebo-controlled, Multicenter Clinical Trial Recruiting NCT03333265 Phase 2, Phase 3 100mg Berberine hydrochloride;300mg Berberine hydrochloride;Placebo Oral Tablet
15 Enteric-coated Aspirin for Prevention of Postsurgical Recurrence and Metastasis in Asian Colorectal Cancer Patients (the APREMEC Trial): a Large-scale Multicenter Randomized Double-blind Placebo-controlled Trial Recruiting NCT02607072 Phase 3 Acetylsalicylic acid (ASA)/aspirin 200 mg daily;Acetylsalicylic acid (ASA)/aspirin 100 mg daily;Placebo
16 A Clinical Trial Evaluating the Efficacy and Safety of a Combination Treatment Administered Over 3 Years in Patients at Risk of Experiencing Recurrence of Colorectal Adenomas Terminated NCT00486512 Phase 3 aspirin, 1,25-dihydroxycholecalciferol, calcium;placebo
17 Statin Polyp Prevention Trial in Patients With Resected Colon Cancer Terminated NCT01011478 Phase 3 rosuvastatin
18 Evaluation of the Efficacy of a Combination of Micronutrients (Vitamin A, C, E, Selenium and Zinc) in Reducing the Incidence of Colorectal Metachronous Adenomas. A Double Blind, Phase III, Randomized, Placebo-controlled Trial Terminated NCT01437826 Phase 3 antioxidants;placebo
19 Prospective Study on Aspirin Efficacy in Reducing Colorectal Adenoma Recurrence Terminated NCT00224679 Phase 3 Aspirin
20 Minimizing the Risk of Metachronous Adenomas of the Colorectum With Green Tea Extract -MIRACLE- Unknown status NCT01360320 Phase 2
21 Chemopreventive Effects of Mesalazine in Patients at High Risk of Recurrent (Nonfamilial) Colorectal Adenomas Completed NCT01894685 Phase 2 Mesalazine;Placebo
22 3389 Colorectal Adenoma: Chemoprevention With Folic Acid Completed NCT00018551 Phase 2 Folic Acid
23 Randomized, Placebo-Controlled, Phase 2B Evaluation of Cyclooxygenase-2 Activity in Surgically Resected Primary Colorectal Adenomas and Carcinomas After 7 Days Pretreatment With Celecoxib Completed NCT00582660 Phase 2 Celecoxib;Placebo
24 A Phase IIa Trial of Metformin for Colorectal Cancer Risk Reduction Among Patients With a History of Colorectal Adenomas and Elevated Body Mass Index Completed NCT01312467 Phase 2 metformin hydrochloride
25 Study of the MUC1 Peptide - Poly-ICLC Adjuvant Vaccine in Individuals With Advanced Colorectal Adenoma Completed NCT00773097 Phase 2
26 Genetic Events Leading to APC-Dependent Colon Cancer in High-Risk Families; a Clinical Trial of COX and EGFR Inhibition in Familial Polyposis Patients Completed NCT01187901 Phase 2 Erlotinib;Sulindac;Placebo A;Placebo B
27 A Phase I/II Study of T Cell Receptor Gene Therapy Targeting HPV-16 E6 for HPV-Associated Cancers Completed NCT02280811 Phase 1, Phase 2 Fludarabine;Cyclophosphamide;Aldesleukin
28 Fatty Acid Desaturase Activity, Fish Oil and Colorectal Cancer Prevention Completed NCT01661764 Phase 2 Eicosapentanoic acid and docosahexanoic acid;Oleic Acid
29 Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention Recruiting NCT02965703 Phase 2 Aspirin
30 A Randomized, Phase II, Double-blind, Placebo-controlled, Multicenter, 2x2 Factorial Design Biomarker Tertiary Prevention Trial of Low-dose Aspirin and Metformin in Stage I-III Colorectal Cancer Patients. The ASAMET Trial Recruiting NCT03047837 Phase 2 Aspirin (ASA) + Metformin (MET);ASA;MET;Placebos
31 Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Vaccine in Patients With Newly Diagnosed Advanced Adenomas Active, not recruiting NCT02134925 Phase 2
32 Phase II Randomized, Placebo-Controlled Trial of Linaclotide to Demonstrate Bioactivity in Patients With Sporadic Colorectal Adenomas and With Colorectal Cancer Not yet recruiting NCT03796884 Phase 2 Linaclotide
33 Panoramic Screening by Complete Colonoscopy in the Management of Colorectal Adenomas Not yet recruiting NCT03961893 Phase 2
34 Phase 2 Prospective Randomized Double Blind Trial Comparing Metastasectomy Plus Sulindac Versus Metastasectomy Alone in Patients With Stage IV Colorectal Cancer Terminated NCT01856322 Phase 2 Sulindac;Placebo
35 Randomized Phase II Trial of Polyphenon E vs.Placebo in Patients at High Risk of Recurrent Colonic Neoplasia Terminated NCT01606124 Phase 2 defined green tea catechin extract
36 Celecoxib Window of Opportunity Trial to Assess Tumor and Stroma Responses Withdrawn NCT03185871 Phase 2 Celecoxib
37 Detection of Colorectal Adenomas in Côte-d'Or: Impact of Organized Screening on Socio-geographic Disparities Unknown status NCT02859714
38 Detection of Colorectal Adenoma by Optical Enhancement Technology vs. High-Definition Colonoscopy: A Randomized Trial Unknown status NCT02865382
39 Clinical Study That Effect of Individualized Intervention of Single Colonoscopy on Colorectal Adenomas Detection Unknown status NCT02693886
40 UKCAP Trial: A Multi-Center Double Blind Randomised Controlled Trial Of Aspirin And/Or Folate Supplementation For the Prevention Of Recurrent Colorectal Adenomas Unknown status NCT00033319 acetylsalicylic acid
41 Prevalence of Colorectal Adenoma in 30- to 49-year-old Asymptomatic Subjects With a First Relative History of Colorectal Cancer Unknown status NCT01428752
42 Endoscopic Full Thickness Resection in the Lower GI Tract With the "Full Thickness Resection Device"- A Prospective Multicenter Trial Unknown status NCT02362126
43 Intubation Techniques on Colonoscopy Quality: A Single Center Randomized Control Clinical Trial Unknown status NCT01919463
44 Comparison of Detection and Miss Rates of Colorectal Adenoma by Blue Laser Imaging (BLI) Versus Conventional White Light Colonoscopy. Unknown status NCT02982447
45 Study of Fecal Bacteria in Early Diagnosis of Colorectal Cancer Unknown status NCT02845973
46 A Pilot Study to Assess the Role for Endocuff© Assisted Colonoscopy in the Detection of Colonic Cancer and Polyps Unknown status NCT01761097
47 Effect of Water Exchange Method on Adenoma Miss Rates in Patients Undergoing Selective Polypectomy: a Single-centered, Randomized Controlled Study Unknown status NCT02880748
48 Impact of DietarY and LIfestyle Risk Factors on Colorectal Cancer Screening (IDYLIC Study). Is it Possible to Target Risk Subjects by Using a Predictive Score? Unknown status NCT02804802
49 Detect InSpect ChAracterise Resect and Discard 2 Unknown status NCT01603927
50 Evaluation of the Colonoscope With Vision to 330 ° (Full Spectrum Endoscopy) in the Detection of Colorectal Adenomas Completed NCT02859870

Search NIH Clinical Center for Colorectal Adenoma

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Acetylsalicylic acid

Genetic Tests for Colorectal Adenoma

Genetic tests related to Colorectal Adenoma:

# Genetic test Affiliating Genes
1 Colorectal Adenoma 29

Anatomical Context for Colorectal Adenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Colorectal Adenoma:

19
Colon, Rectum

MalaCards organs/tissues related to Colorectal Adenoma:

41
Colon, Testes, Liver, Prostate, T Cells, Bone, Breast

Publications for Colorectal Adenoma

Articles related to Colorectal Adenoma:

(show top 50) (show all 3694)
# Title Authors PMID Year
1
Importance of Resection Margins in the Treatment of Rectal Adenomas by Transanal Endoscopic Surgery. 38
30306452 2019
2
Evaluation of Fecal M2PK as a Diagnostic Marker in Colorectal Cancer. 38
29626277 2019
3
Role of Circulating and Supplemental Calcium and Vitamin D in the Occurrence and Development of Colorectal Adenoma or Colorectal Cancer. 38
28134636 2019
4
A Review of the Management of Sporadic Colorectal Adenomas in Young People: Is Surveillance Wasted on the Young? 38
30788685 2019
5
MicroRNA expression profiling in the colorectal normal-adenoma-carcinoma transition. 38
31423272 2019
6
Dietary intake of polyphenols and risk of colorectal cancer and adenoma-A case-control study from Iran. 38
31331573 2019
7
Folic acid supplementation and risk of colorectal neoplasia during long-term follow-up of a randomized clinical trial. 38
31401653 2019
8
Serum CCL20 combined with IL-17A as early diagnostic and prognostic biomarkers for human colorectal cancer. 38
31387598 2019
9
Optimizing the timing of colorectal surgery in patients with familial adenomatous polyposis in clinical practice. 38
31401889 2019
10
APC transcription studies and molecular diagnosis of familial adenomatous polyposis. 38
31383941 2019
11
Molecular characterization of colorectal adenomas reveals POFUT1 as a candidate driver of tumor progression. 38
31411736 2019
12
Comparison of the detection of colorectal lesions in different endoscopic modalities: A network meta-analysis and systematic review. 38
31258649 2019
13
Calcium Intake and Health. 38
31311164 2019
14
Genome-wide DNA methylation analysis of colorectal adenomas with and without recurrence reveals an association between cytosine-phosphate-guanine methylation and histological subtypes. 38
31334584 2019
15
Incidence of composite intestinal adenoma-microcarcinoid in 158 surgically resected polyps and its association with squamous morule. 38
31326865 2019
16
Global Prevalence of Colorectal Neoplasia: a Systematic Review and Meta-analysis. 38
31323383 2019
17
Association of visceral adiposity and insulin resistance with colorectal adenoma and colorectal cancer. 38
30419640 2019
18
Korean Alcohol Guidelines for Moderate Drinking Based on Facial Flushing. 38
31302995 2019
19
Chemoprevention of Colorectal Cancer: Past, Present, and Future. 38
31361372 2019
20
Association between High Levels of Circulating Chemerin and Colorectal Adenoma in Men. 38
31269491 2019
21
Genetic Aberration Analysis in Thai Colorectal Adenoma and Early-Stage Adenocarcinoma Patients by Whole-Exome Sequencing. 38
31336886 2019
22
Role of ERCC1 expression in colorectal adenoma-carcinoma sequence and relation to other mismatch repair proteins expression, clinicopathological features and prognosis in mucinous and non-mucinous colorectal carcinoma. 38
31361228 2019
23
Hormone replacement therapies, oral contraceptives, reproductive factors and colorectal adenoma risk: a systematic review and dose-response meta-analysis of observational studies. 38
30748083 2019
24
Effects of supplemental calcium and vitamin D on tight-junction proteins and mucin-12 expression in the normal rectal mucosa of colorectal adenoma patients. 38
30938860 2019
25
Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses' Health Study II. 38
31114018 2019
26
Uncovering the clinical impact of kallikrein-related peptidase 5 (KLK5) mRNA expression in the colorectal adenoma-carcinoma sequence. 38
30759066 2019
27
Circulating inflammation markers and colorectal adenoma risk. 38
30753331 2019
28
Impact of linked-color imaging on colorectal adenoma detection. 38
31302092 2019
29
Dose-response meta-analysis of coffee consumption and risk of colorectal adenoma. 38
31308476 2019
30
Body Composition and Aspirin Dose for Colorectal Adenoma Prevention in a Randomized Clinical Trial. 38
31263057 2019
31
The short-term outcomes of laparoscopic-endoscopic cooperative surgery for colorectal tumors (LECS-CR) in cases involving endoscopically unresectable colorectal tumors. 38
31250113 2019
32
Aspirin, Eicosapentaenoic Acid, and Placebo Equally Effective in Preventing Colorectal Adenomas in High-Risk Patients. 38
31150179 2019
33
Incidence of Advanced Colorectal Neoplasia in Individuals With Untreated Diminutive Colorectal Adenomas Diagnosed by Magnifying Image-Enhanced Endoscopy. 38
31082873 2019
34
Serum vitamin D levels correlate with the presence and histological grading of colorectal adenomas in peri and postmenopausal women. 38
29961649 2019
35
Giant villous adenoma of rectum- what is the malignant potential and what is the optimal treatment? A case and review of literature. 38
31238922 2019
36
Rapid, High-Resolution, Label-Free, and 3-Dimensional Imaging to Differentiate Colorectal Adenomas and Non-Neoplastic Polyps With Micro-Optical Coherence Tomography. 38
31192828 2019
37
Outcomes of endoscopic resection of large colorectal lesions subjected to prior failed resection or substantial manipulation. 38
30944999 2019
38
Epidermal growth factor receptor-targeted molecular imaging of colorectal tumors: Detection and treatment evaluation of tumors in animal models. 38
30973663 2019
39
Clips for managing perforation and bleeding after colorectal endoscopic mucosal resection. 38
31109217 2019
40
Relationship between Barrett's esophagus and colonic diseases: a role for colonoscopy in Barrett's surveillance. 38
31240437 2019
41
NTHL1 biallelic mutations seldom cause colorectal cancer, serrated polyposis or a multi-tumor phenotype, in absence of colorectal adenomas. 38
31227763 2019
42
Association between NAFLD and Risk of Colorectal Adenoma in Chinese Han Population. 38
31293908 2019
43
Chronic liver disease promotes lesions of the colorectal adenoma-carcinoma sequence, independent of liver cirrhosis. 38
31210944 2019
44
CD204-Positive Tumor-associated Macrophages Relate to Malignant Transformation of Colorectal Adenoma. 38
31177112 2019
45
Risk Factors for Colorectal Adenoma - Acknowledging the Burden of NAFLD. 38
31293907 2019
46
(Pro)renin Receptor Expression Increases throughout the Colorectal Adenoma-Adenocarcinoma Sequence and It Is Associated with Worse Colorectal Cancer Prognosis. 38
31238566 2019
47
Decrease of variation in the grading of dysplasia in colorectal adenomas with a national e-learning module. 38
30725483 2019
48
Right-Sided Location Not Associated With Missed Colorectal Adenomas in an Individual-Level Reanalysis of Tandem Colonoscopy Studies. 38
31103625 2019
49
Correlation of molecular and morphological features of appendiceal epithelial neoplasms. 38
31111538 2019
50
Decreased Colorectal Adenoma Risk After Helicobacter pylori Eradication: A Retrospective Cohort Study. 38
30566695 2019

Variations for Colorectal Adenoma

ClinVar genetic disease variations for Colorectal Adenoma:

6 (show all 13)
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 APC NM_000038.6(APC): c.4360A> G (p.Lys1454Glu) single nucleotide variant Conflicting interpretations of pathogenicity rs111866410 5:112175651-112175651 5:112839954-112839954
2 APC NM_000038.6(APC): c.4237A> G (p.Met1413Val) single nucleotide variant Conflicting interpretations of pathogenicity rs141519952 5:112175528-112175528 5:112839831-112839831
3 APC NM_000038.6(APC): c.8266A> G (p.Ile2756Val) single nucleotide variant Conflicting interpretations of pathogenicity rs146115809 5:112179557-112179557 5:112843860-112843860
4 APC NM_000038.6(APC): c.4732T> G (p.Cys1578Gly) single nucleotide variant Conflicting interpretations of pathogenicity rs138367627 5:112176023-112176023 5:112840326-112840326
5 APC NM_000038.6(APC): c.8383G> A (p.Ala2795Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs369264968 5:112179674-112179674 5:112843977-112843977
6 APC NM_000038.6(APC): c.3479C> A (p.Thr1160Lys) single nucleotide variant Conflicting interpretations of pathogenicity rs201004111 5:112174770-112174770 5:112839073-112839073
7 APC NM_000038.6(APC): c.7717A> G (p.Ile2573Val) single nucleotide variant Conflicting interpretations of pathogenicity rs145444830 5:112179008-112179008 5:112843311-112843311
8 APC NM_000038.6(APC): c.2847G> T (p.Met949Ile) single nucleotide variant Conflicting interpretations of pathogenicity rs147394539 5:112174138-112174138 5:112838441-112838441
9 APC NM_000038.6(APC): c.7778A> G (p.Asn2593Ser) single nucleotide variant Uncertain significance rs367676584 5:112179069-112179069 5:112843372-112843372
10 APC NM_000038.6(APC): c.449A> G (p.Lys150Arg) single nucleotide variant Uncertain significance rs371085910 5:112111352-112111352 5:112775655-112775655
11 APC NM_000038.6(APC): c.4420G> A (p.Ala1474Thr) single nucleotide variant Benign/Likely benign rs139387758 5:112175711-112175711 5:112840014-112840014
12 APC NM_000038.6(APC): c.6985A> G (p.Ile2329Val) single nucleotide variant Benign/Likely benign rs146048493 5:112178276-112178276 5:112842579-112842579
13 APC NM_000038.6(APC): c.4336G> A (p.Ala1446Thr) single nucleotide variant Benign/Likely benign rs146572883 5:112175627-112175627 5:112839930-112839930

Expression for Colorectal Adenoma

LifeMap Discovery
Genes differentially expressed in tissues of Colorectal Adenoma patients vs. healthy controls: 35 (show top 50) (show all 255)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 GCG glucagon Colon - 9.14 0.000
2 GUCA2B guanylate cyclase activator 2B (uroguanylin) Colon - 8.78 0.000
3 MS4A12 membrane-spanning 4-domains, subfamily A, member 12 Colon - 8.78 0.000
4 AQP8 aquaporin 8 Colon - 8.30 0.000
5 CA1 carbonic anhydrase I Colon - 8.11 0.000
6 CLCA4 chloride channel accessory 4 Colon - 7.63 0.000
7 CA4 carbonic anhydrase IV Colon - 7.51 0.000
8 TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) Colon + 7.34 0.000
9 CLDN8 claudin 8 Colon - 7.18 0.000
10 CDH3 cadherin 3, type 1, P-cadherin (placental) Colon + 6.97 0.000
11 GUCA2A guanylate cyclase activator 2A (guanylin) Colon - 6.92 0.000
12 HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 Colon - 6.85 0.001
13 PRAC1 prostate cancer susceptibility candidate 1 Colon - 6.72 0.040
14 CEMIP cell migration inducing protein, hyaluronan binding Colon + 6.69 0.000
15 INSL5 insulin-like 5 Colon - 6.67 0.000
16 PYY peptide YY Colon - 6.57 0.000
17 SCNN1B sodium channel, non voltage gated 1 beta subunit Colon - 6.53 0.000
18 CHGA chromogranin A Colon - 6.30 0.000
19 SST somatostatin Colon - 5.99 0.000
20 ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) Colon - 5.77 0.002
21 SLC51B solute carrier family 51, beta subunit Colon - 5.54 0.001
22 CD177 CD177 molecule Colon - 5.52 0.003
23 GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) Colon - 5.48 0.000
24 SLC25A34 solute carrier family 25, member 34 Colon - 5.43 0.000
25 SLC26A3 solute carrier family 26 (anion exchanger), member 3 Colon - 5.39 0.002
26 CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) Colon - 5.35 0.000
27 ZG16 zymogen granule protein 16 Colon - 5.34 0.000
28 MSX2 msh homeobox 2 Colon + 5.31 0.000
29 FABP6 fatty acid binding protein 6, ileal Colon + 5.29 0.000
30 EPHX4 epoxide hydrolase 4 Colon + 5.24 0.000
31 DUSP27 dual specificity phosphatase 27 (putative) Colon + 5.23 0.000
32 TACSTD2 tumor-associated calcium signal transducer 2 Colon + 5.10 0.000
33 GABRP gamma-aminobutyric acid (GABA) A receptor, pi Colon + 5.08 0.003
34 BEST4 bestrophin 4 Colon - 5.08 0.001
35 S100A2 S100 calcium binding protein A2 Colon + 5.05 0.000
36 DPEP1 dipeptidase 1 (renal) Colon + 5.04 0.010
37 MUC12 mucin 12, cell surface associated Colon - 4.98 0.020
38 SPINK5 serine peptidase inhibitor, Kazal type 5 Colon - 4.96 0.001
39 PCSK1 proprotein convertase subtilisin/kexin type 1 Colon + 4.92 0.008
40 SLC30A10 solute carrier family 30, member 10 Colon - 4.89 0.003
41 TMEM72 transmembrane protein 72 Colon - 4.88 0.000
42 KLK10 kallikrein-related peptidase 10 Colon + 4.85 0.020
43 CDH19 cadherin 19, type 2 Colon - 4.83 0.001
44 CDKN2B-AS1 CDKN2B antisense RNA 1 Colon - 4.75 0.004
45 MT1M metallothionein 1M Colon - 4.75 0.027
46 SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 Colon - 4.71 0.007
47 PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) Colon - 4.70 0.000
48 ANO5 anoctamin 5 Colon - 4.68 0.000
49 FOXQ1 forkhead box Q1 Colon + 4.62 0.000
50 CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 Colon - 4.60 0.001
Search GEO for disease gene expression data for Colorectal Adenoma.

Pathways for Colorectal Adenoma

Pathways related to Colorectal Adenoma according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 TP53 KRAS IGF1 HRAS CTNNB1 CDH1
2
Show member pathways
12.95 TP53 PTGS2 KRAS IGF1 HRAS CTNNB1
3
Show member pathways
12.92 TP53 PTGS2 MSH2 MLH1 KRAS HRAS
4
Show member pathways
12.73 KRAS IGF1 HRAS CTNNB1 CDH1
5
Show member pathways
12.72 TP53 MSH2 MLH1 KRAS IGF1 HRAS
6
Show member pathways
12.69 TP53 KRAS IGF1 HRAS CDH1
7
Show member pathways
12.61 TP53 PTGS2 KRAS HRAS CTNNB1 CDH1
8
Show member pathways
12.59 TP53 MSH2 KRAS HRAS CTNNB1
9
Show member pathways
12.58 TP53 MLH1 KRAS IGF1 HRAS GSTM1
10 12.53 TP53 PTGS2 KRAS HRAS APC
11 12.5 TP53 MUTYH MSH2 MLH1 MGMT
12
Show member pathways
12.49 TP53 KRAS IGF1 HRAS APC
13
Show member pathways
12.45 TP53 SFRP2 CTNNB1 APC
14
Show member pathways
12.43 TP53 KRAS HRAS CTNNB1
15 12.41 TP53 PTGS2 CTNNB1 CDH1 APC
16
Show member pathways
12.39 PTGS2 KRAS HRAS CTNNB1
17
Show member pathways
12.39 TP53 IGFBP3 IGF1 HRAS
18
Show member pathways
12.37 KRAS IGF1 HRAS CTNNB1 CDH1 APC
19 12.34 TP53 KRAS HRAS CTNNB1 APC
20
Show member pathways
12.33 TP53 PTGS2 MTR MTHFR
21 12.27 TP53 KRAS IGF1 HRAS CTNNB1
22 12.17 TP53 KRAS IGFBP3 HRAS
23
Show member pathways
12.13 TP53 KRAS IGF1 HRAS
24 12.11 TP53 MSH2 KRAS CTNNB1 CDH1
25 12.09 TP53 PTGS2 MSH2 MLH1 KRAS IGF1
26 12.05 KRAS IGF1 HRAS CTNNB1 APC
27 12 TP53 KRAS HRAS CTNNB1
28
Show member pathways
11.98 TP53 PTGS2 CTNNB1 CDH1 APC
29 11.97 VDR TP53 MSH2 MLH1 IGFBP3 APC
30 11.96 KRAS HRAS CTNNB1 CDH1 APC
31 11.93 TP53 IGFBP3 IGF1 HRAS
32 11.92 TP53 KRAS HRAS CTNNB1 APC
33 11.78 TP53 PTGS2 MSH2 MLH1 KRAS CTNNB1
34 11.77 CTNNB1 CDH1 APC
35 11.75 TP53 MGMT KRAS IGF1 HRAS CTNNB1
36 11.72 TP53 MSH2 MLH1 GSTM1
37 11.71 TP53 KRAS HRAS
38 11.71 TP53 KRAS HRAS CDH1
39 11.68 TP53 KRAS HRAS
40 11.64 KRAS IGF1 HRAS
41 11.62 PTGS2 IGFBP3 CTNNB1
42 11.54 TP53 MSH2 MLH1 KRAS HRAS
43 11.53 PTGS2 KRAS HRAS
44
Show member pathways
11.44 MSH2 MLH1 MGMT GSTM1
45
Show member pathways
11.42 TP53 MSH2 MLH1
46 11.39 TP53 PTGS2 IGFBP3
47 11.3 TP53 KRAS HRAS
48 11.25 MSH2 MLH1 GSTM1
49 11.18 KRAS HRAS CTNNB1 APC
50
Show member pathways
11.17 KRAS IGF1 HRAS

GO Terms for Colorectal Adenoma

Cellular components related to Colorectal Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lateral plasma membrane GO:0016328 9.43 CTNNB1 CDH1 APC
2 beta-catenin destruction complex GO:0030877 9.4 CTNNB1 APC
3 Wnt signalosome GO:1990909 9.37 CTNNB1 APC
4 flotillin complex GO:0016600 9.32 CTNNB1 CDH1
5 insulin-like growth factor ternary complex GO:0042567 9.16 IGFBP3 IGF1
6 insulin-like growth factor binding protein complex GO:0016942 8.96 IGFBP3 IGF1
7 catenin complex GO:0016342 8.8 CTNNB1 CDH1 APC

Biological processes related to Colorectal Adenoma according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.99 TP53 PTGS2 MGMT IGF1 GREM1 CTNNB1
2 regulation of apoptotic process GO:0042981 9.93 TP53 SFRP2 IGFBP3 CTNNB1
3 negative regulation of gene expression GO:0010629 9.92 SFRP2 IGF1 HRAS CTNNB1
4 cellular response to DNA damage stimulus GO:0006974 9.91 TP53 MUTYH MSH2 MLH1 MGMT APC
5 positive regulation of gene expression GO:0010628 9.85 VDR TP53 KRAS IGF1 HRAS CTNNB1
6 cell cycle arrest GO:0007050 9.8 TP53 MSH2 HRAS APC
7 positive regulation of MAPK cascade GO:0043410 9.78 IGFBP3 IGF1 HRAS CTNNB1
8 positive regulation of osteoblast differentiation GO:0045669 9.74 SFRP2 IGF1 CTNNB1
9 positive regulation of apoptotic process GO:0043065 9.73 TP53 SFRP2 PTGS2 IGFBP3 CTNNB1 APC
10 positive regulation of cell proliferation GO:0008284 9.7 SFRP2 PTGS2 KRAS IGF1 HRAS GREM1
11 mismatch repair GO:0006298 9.63 MUTYH MSH2 MLH1
12 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.62 IGFBP3 IGF1
13 Ras protein signal transduction GO:0007265 9.62 TP53 KRAS IGF1 HRAS
14 methionine biosynthetic process GO:0009086 9.61 MTR MTHFR
15 positive regulation of isotype switching to IgG isotypes GO:0048304 9.61 MSH2 MLH1
16 response to folic acid GO:0051593 9.6 MTHFR MGMT
17 entry of bacterium into host cell GO:0035635 9.59 CTNNB1 CDH1
18 response to isolation stress GO:0035900 9.58 KRAS HRAS
19 signal transduction by p53 class mediator GO:0072331 9.56 TP53 GREM1
20 positive regulation of isotype switching to IgA isotypes GO:0048298 9.55 MSH2 MLH1
21 cellular response to indole-3-methanol GO:0071681 9.54 CTNNB1 CDH1
22 somatic recombination of immunoglobulin gene segments GO:0016447 9.52 MSH2 MLH1
23 response to drug GO:0042493 9.43 SFRP2 PTGS2 MTHFR MGMT CTNNB1 CDH1
24 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.4 MSH2 MLH1
25 negative regulation of cell proliferation GO:0008285 9.23 VDR TP53 SFRP2 PTGS2 IGFBP3 HRAS
26 positive regulation of transcription by RNA polymerase II GO:0045944 10.13 VDR TP53 SFRP2 IGF1 HRAS GREM1

Molecular functions related to Colorectal Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 9.4 MSH2 MLH1
2 gamma-catenin binding GO:0045295 9.37 CDH1 APC
3 oxidized purine DNA binding GO:0032357 9.32 MUTYH MSH2
4 MutSalpha complex binding GO:0032407 9.26 MUTYH MLH1
5 MutLalpha complex binding GO:0032405 9.16 MUTYH MSH2
6 enzyme binding GO:0019899 9.1 TP53 PTGS2 MSH2 MLH1 GSTM1 CTNNB1
7 guanine/thymine mispair binding GO:0032137 8.96 MSH2 MLH1

Sources for Colorectal Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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