CRCS1
MCID: CLR085
MIFTS: 42

Colorectal Cancer 1 (CRCS1)

Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Colorectal Cancer 1

MalaCards integrated aliases for Colorectal Cancer 1:

Name: Colorectal Cancer 1 57 72 29 6
Colorectal Cancer, Susceptibility to, 1 57 13
Crcs1 57 72
Colorectal Cancer, Susceptibility to, on Chromosome 9 57
Susceptibility to Colorectal Cancer on Chromosome 9 72
Colorectal Adenoma and Cancer, Susceptibility to 57
Susceptibility to Colorectal Adenoma and Cancer 72
Cancer, Colorectal, Susceptibility to, Type 1 39
Colorectal Cancer on Chromosome 9 57
Colorectal Adenoma and Cancer 57

Classifications:



External Ids:

OMIM® 57 608812
MeSH 44 D015179
MedGen 41 C1837315

Summaries for Colorectal Cancer 1

UniProtKB/Swiss-Prot : 72 Colorectal cancer 1: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.

MalaCards based summary : Colorectal Cancer 1, also known as colorectal cancer, susceptibility to, 1, is related to adenoma and lynch syndrome i. An important gene associated with Colorectal Cancer 1 is GALNT12 (Polypeptide N-Acetylgalactosaminyltransferase 12), and among its related pathways/superpathways are Innate Immune System and HIV Life Cycle. Affiliated tissues include colon, pancreas and appendix.

More information from OMIM: 608812

Related Diseases for Colorectal Cancer 1

Diseases in the Colorectal Cancer family:

Colorectal Cancer 1 Colorectal Cancer 2
Colorectal Cancer 3 Colorectal Cancer 5
Colorectal Cancer 6 Colorectal Cancer 7
Colorectal Cancer 8 Colorectal Cancer 9
Colorectal Cancer 10 Colorectal Cancer 11
Colorectal Cancer 12 Familial Colorectal Cancer
Familial Colorectal Cancer Type X

Diseases related to Colorectal Cancer 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 adenoma 29.5 MUC6 MUC5AC MUC1 MSH2
2 lynch syndrome i 11.4
3 colorectal adenoma 10.8
4 cerebral primitive neuroectodermal tumor 10.4 MUC1 MSH2
5 cystadenofibroma 10.3 MUC16 MUC1
6 adenofibroma 10.3 MUC16 MUC1
7 pericardial mesothelioma 10.3 MUC16 MUC1
8 pancreatic signet ring cell adenocarcinoma 10.2 MUC5AC MUC1
9 lung sarcomatoid carcinoma 10.2 MUC4 MUC1
10 mammary analogue secretory carcinoma 10.2 MUC4 MUC1
11 glandular cystitis 10.2 MUC5AC MUC1
12 atopic keratoconjunctivitis 10.2 MUC5AC MUC16
13 punctate epithelial keratoconjunctivitis 10.2 MUC5AC MUC16
14 mucinous adenocarcinoma 10.1 MUC5AC MUC16 MUC1
15 adenomyoma 10.1 MUC4 MUC1
16 acute cholangitis 10.1 MUC5AC MUC1
17 interstitial pneumonitis, desquamative, familial 10.1 MUC5B MUC1
18 colorectal cancer, hereditary nonpolyposis, type 8 10.1 MUC5AC MUC16 MUC1
19 colorectal cancer 10.1
20 pancreatic mucinous cystadenoma 10.1 MUC5AC MUC2 MUC1
21 meconium ileus 10.1 MUC5AC MUC2 MUC1
22 ampulla of vater adenocarcinoma 10.1 MUC5AC MUC2 MUC1
23 tubular adenocarcinoma 10.1 MUC5AC MUC2 MUC1
24 mucinous cystadenocarcinoma 10.1 MUC16 MUC1
25 lung mucoepidermoid carcinoma 10.1 MUC5AC MUC3A
26 ovarian mucinous adenocarcinoma 10.1 MUC5AC MUC2
27 cervical adenoma malignum 10.0 MUC6 MSH2
28 intrahepatic cholangiocarcinoma 10.0 MUC5AC MUC4 MUC1
29 limbal stem cell deficiency 10.0 MUC5AC MUC4 MUC1
30 senile ectropion 10.0 MUC5AC MUC4 MUC16
31 complete androgen insensitivity syndrome 10.0 MUC5AC MUC1
32 dry eye syndrome 10.0 MUC5AC MUC4 MUC1
33 cystadenocarcinoma 10.0 MUC5AC MUC2 MUC16 MUC1
34 insulin-like growth factor i 10.0
35 body mass index quantitative trait locus 11 10.0
36 body mass index quantitative trait locus 9 10.0
37 body mass index quantitative trait locus 8 10.0
38 body mass index quantitative trait locus 1 10.0
39 body mass index quantitative trait locus 4 10.0
40 body mass index quantitative trait locus 10 10.0
41 body mass index quantitative trait locus 7 10.0
42 body mass index quantitative trait locus 12 10.0
43 body mass index quantitative trait locus 14 10.0
44 body mass index quantitative trait locus 18 10.0
45 body mass index quantitative trait locus 19 10.0
46 colorectal adenocarcinoma 10.0
47 colon adenoma 10.0
48 rectum cancer 10.0
49 liver disease 10.0
50 fatty liver disease 10.0

Graphical network of the top 20 diseases related to Colorectal Cancer 1:



Diseases related to Colorectal Cancer 1

Symptoms & Phenotypes for Colorectal Cancer 1

Clinical features from OMIM®:

608812 (Updated 20-May-2021)

Drugs & Therapeutics for Colorectal Cancer 1

Search Clinical Trials , NIH Clinical Center for Colorectal Cancer 1

Genetic Tests for Colorectal Cancer 1

Genetic tests related to Colorectal Cancer 1:

# Genetic test Affiliating Genes
1 Colorectal Cancer 1 29 GALNT12

Anatomical Context for Colorectal Cancer 1

MalaCards organs/tissues related to Colorectal Cancer 1:

40
Colon, Pancreas, Appendix, Lung, Small Intestine, Liver, Eye

Publications for Colorectal Cancer 1

Articles related to Colorectal Cancer 1:

(show top 50) (show all 65)
# Title Authors PMID Year
1
Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers. 57 6
19617566 2009
2
Germline allele-specific expression of TGFBR1 confers an increased risk of colorectal cancer. 57
18703712 2008
3
Linkage analysis in a large Swedish family supports the presence of a susceptibility locus for adenoma and colorectal cancer on chromosome 9q22.32-31.1. 57
16467217 2006
4
A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2. 57
14566058 2003
5
Wnt7a Promotes the Occurrence and Development of Colorectal Adenocarcinoma. 61
33791195 2021
6
High-definition colonoscopy for improving adenoma detection: a systematic review and meta-analysis of randomized controlled studies. 61
31954133 2020
7
Telomerase reverse transcriptase promoter mutations in cancers derived from multiple organ sites among middle eastern population. 61
31669704 2020
8
Quality of Life and Severity of Symptom Differences Between Post Open Colectomy and Laparoscopic Colectomy in Colorectal Cancer Patients. 61
32132368 2020
9
Prediction of advanced colonic neoplasm in symptomatic patients: a scoring system to prioritize colonoscopy (COLONOFIT study). 61
31345180 2019
10
Estimates of global chemotherapy demands and corresponding physician workforce requirements for 2018 and 2040: a population-based study. 61
31078462 2019
11
Genotype-phenotype correlation in 99 familial adenomatous polyposis patients: A prospective prevention protocol. 61
30897307 2019
12
Application of ultrasonography to high-tie and low-tie vascular ligation of the inferior mesenteric artery in laparoscopic colorectal cancer surgery: technical notes. 61
29943055 2019
13
Cross talk of chromosome instability, CpG island methylator phenotype and mismatch repair in colorectal cancer. 61
30008861 2018
14
Cancer Screening Test Use - United States, 2015. 61
28253225 2017
15
Simultaneous PET/MRI vs PET/CT in oncology. A systematic review. 61
27424217 2016
16
appendix 4: Metastatic colorectal cancer (1): eUpdate published online September 2016 (www.esmo.org/Guidelines/Gastrointestinal-Cancers). 61
27664252 2016
17
Data on clinical significance of GAS2 in colorectal cancer cells. 61
27284567 2016
18
Utilization of supportive care by survivors of colorectal cancer: results from the PROFILES registry. 61
26842528 2016
19
Role of yttrium-90 in the management of unresectable hepatocellular carcinoma and hepatic metastases. 61
27185180 2016
20
Optimal duration of a first-line palliative chemotherapy in disseminated colorectal cancer - a review of the literature from a developing country perspective. 61
27647984 2016
21
Prophylaxis for Venous Thromboembolism After Laparoscopic Surgery for Colorectal Cancer: 1 Week or 4 Week? 61
24887974 2015
22
A phase 1 clinical trial of sequential pralatrexate followed by a 48-hour infusion of 5-fluorouracil given every other week in adult patients with solid tumors. 61
26242208 2015
23
Risk of Gastric and Colorectal Cancer After Tamoxifen Use for Breast Cancer: A Systematic Review and Meta-Analysis. 61
25319737 2015
24
Data supporting the identification of compound for inhibition of survivin of colorectal cancer by using ingenuity pathway analysis of gene expression profiling of colorectal cancer tissues. 61
26217796 2015
25
The extent of inflammatory infiltration in primary cancer tissues is associated with lymphomagenesis in immunodeficient mice. 61
25819560 2015
26
No association of single nucleotide polymorphisms involved in GHRL and GHSR with cancer risk: a meta-analysis. 61
25524946 2015
27
Health-related quality of life and risk of colorectal cancer recurrence and All-cause death among advanced stages of colorectal cancer 1-year after diagnosis. 61
24886385 2014
28
Invasion patterns in brain metastases of solid cancers. 61
24084410 2013
29
A method for differentiating cancer prevalence according to health status, exemplified using a population-based sample of Italian colorectal cancer cases. 61
23215872 2013
30
[Current role of prostatic transrectal ultrasound in the diagnosis of CaP]. 61
22427243 2012
31
Safety, efficacy and pharmacokinetics of neratinib (HKI-272) in Japanese patients with advanced solid tumors: a Phase 1 dose-escalation study. 61
22371427 2012
32
Determinants of patient survival rate after implantation of a cardioverter-defibrillator without resynchronisation capability. 61
23180517 2012
33
Combined resection of the liver and pancreas for malignancy. 61
20421055 2010
34
PTPRJ haplotypes and colorectal cancer risk. 61
18843023 2008
35
[Folic acid and prevention of neural tube closure defects: the question is not solved yet]. 61
18562183 2008
36
The use of irinotecan, oxaliplatin and raltitrexed for the treatment of advanced colorectal cancer: systematic review and economic evaluation. 61
18462574 2008
37
Study of colorectal cancer with Crohn's disease. 61
17970041 2007
38
Using prescription claims data for drugs available over-the-counter (OTC). 61
17654746 2007
39
What we have learned from 5 cases of permanent capsule retention. 61
16860090 2006
40
[Colorectal cancer, 1. and 2. part, Ugeskrift for Laeger nr 44 and 45]. 61
16393576 2006
41
Method of presenting oncology treatment outcomes influences patient treatment decision-making in metastatic colorectal cancer. 61
16372152 2006
42
A scoring system for the strength of a family history of colorectal cancer. 61
15785893 2005
43
Quality of life in patients with colorectal cancer 1 year after diagnosis compared with the general population: a population-based study. 61
15570086 2004
44
Ex vivo lymphatic mapping: a technique to improve pathologic staging in colorectal cancer. 61
15586501 2004
45
Intravenous vitamin C as a chemotherapy agent: a report on clinical cases. 61
15377059 2004
46
Smoking exposure as a risk factor for prevalent and recurrent colorectal adenomas. 61
14578135 2003
47
Recent advances in colorectal cancer therapy. 61
12673111 2003
48
[Colorectal exfoliated cell in stool and its nuclear DNA quantitative analysis for diagnosis of colorectal cancer]. 61
12479106 2002
49
Multiple factors analysis on liver metastasis from colorectal cancer. 61
12408766 2002
50
Identification of heat shock protein 90 and other proteins as tumour antigens by serological screening of an ovarian carcinoma expression library. 61
12177805 2002

Variations for Colorectal Cancer 1

ClinVar genetic disease variations for Colorectal Cancer 1:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 GALNT12 NM_024642.5(GALNT12):c.3G>A (p.Met1Ile) SNV risk factor 1270 rs267606839 GRCh37: 9:101569983-101569983
GRCh38: 9:98807701-98807701
2 GALNT12 NM_024642.5(GALNT12):c.1185C>G (p.Tyr395Ter) SNV risk factor 1272 rs1588453974 GRCh37: 9:101599403-101599403
GRCh38: 9:98837121-98837121
3 GALNT12 NM_024642.5(GALNT12):c.1472C>T (p.Thr491Met) SNV risk factor 1271 rs267606840 GRCh37: 9:101608272-101608272
GRCh38: 9:98845990-98845990
4 GALNT12 NM_024642.5(GALNT12):c.329G>A (p.Arg110His) SNV Uncertain significance 485648 rs374994372 GRCh37: 9:101570309-101570309
GRCh38: 9:98808027-98808027
5 GALNT12 NM_024642.5(GALNT12):c.1339G>A (p.Gly447Arg) SNV Uncertain significance 485649 rs376441206 GRCh37: 9:101602410-101602410
GRCh38: 9:98840128-98840128
6 GALNT12 NM_024642.5(GALNT12):c.608A>G (p.Asn203Ser) SNV Uncertain significance 410578 rs375844934 GRCh37: 9:101589100-101589100
GRCh38: 9:98826818-98826818
7 GALNT12 NM_024642.5(GALNT12):c.609C>A (p.Asn203Lys) SNV Uncertain significance 485655 rs370024536 GRCh37: 9:101589101-101589101
GRCh38: 9:98826819-98826819
8 GALNT12 NM_024642.5(GALNT12):c.715G>C (p.Glu239Gln) SNV Uncertain significance 485652 rs777144221 GRCh37: 9:101589207-101589207
GRCh38: 9:98826925-98826925
9 GALNT12 NM_024642.5(GALNT12):c.1672A>G (p.Ser558Gly) SNV Uncertain significance 410576 rs759843363 GRCh37: 9:101611300-101611300
GRCh38: 9:98849018-98849018
10 GALNT12 NM_024642.5(GALNT12):c.776T>C (p.Val259Ala) SNV Uncertain significance 220637 rs147356342 GRCh37: 9:101594098-101594098
GRCh38: 9:98831816-98831816

UniProtKB/Swiss-Prot genetic disease variations for Colorectal Cancer 1:

72
# Symbol AA change Variation ID SNP ID
1 GALNT12 p.Arg297Trp VAR_064357 rs149726976
2 GALNT12 p.Asp303Asn VAR_064358 rs145236923
3 GALNT12 p.Glu341Asp VAR_064359
4 GALNT12 p.Arg373His VAR_064360 rs920049418
5 GALNT12 p.Arg382His VAR_064361 rs868590153
6 GALNT12 p.Cys479Phe VAR_064362
7 GALNT12 p.Thr491Met VAR_064363 rs267606840
8 GALNT12 p.Tyr396Cys VAR_068509 rs127253044

Cosmic variations for Colorectal Cancer 1:

9 (show top 50) (show all 745)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM93183877 TP53 large intestine,colon,adenoma,NS c.733G>A p.G245S 17:7674230-7674230 3
2 COSM112254813 TP53 large intestine,rectum,other,ulcerative colitis c.991C>T p.Q331* 17:7673537-7673537 3
3 COSM121879912 TP53 large intestine,rectum,adenoma,NS c.338G>A p.G113D 17:7674229-7674229 3
4 COSM144013587 TP53 large intestine,rectum,adenoma,NS c.700G>A p.G234S 17:7674230-7674230 3
5 COSM142564162 TP53 large intestine,colon,adenoma,NS c.524A>G p.H175R 17:7674890-7674890 3
6 COSM144314088 TP53 large intestine,colon,adenoma,NS c.-87A>C p.? 17:7675221-7675221 3
7 COSM144651337 TP53 large intestine,rectum,adenoma,NS c.616G>A p.G206S 17:7674230-7674230 3
8 COSM144104972 TP53 large intestine,colon,adenoma,NS c.256G>C p.G86R 17:7674230-7674230 3
9 COSM144654651 TP53 large intestine,rectum,adenoma,NS c.617G>A p.G206D 17:7674229-7674229 3
10 COSM122567711 TP53 large intestine,colon,adenoma,NS c.-6A>C p.? 17:7675221-7675221 3
11 COSM144087932 TP53 large intestine,rectum,other,ulcerative colitis c.514C>T p.Q172* 17:7673537-7673537 3
12 COSM144014702 TP53 large intestine,rectum,other,ulcerative colitis c.958C>T p.Q320* 17:7673537-7673537 3
13 COSM121876212 TP53 large intestine,colon,adenoma,NS c.337G>A p.G113S 17:7674230-7674230 3
14 COSM143943997 TP53 large intestine,colon,adenoma,NS c.256G>A p.G86S 17:7674230-7674230 3
15 COSM145017865 TP53 large intestine,colon,adenoma,NS c.616G>A p.G206S 17:7674230-7674230 3
16 COSM143156960 TP53 large intestine,rectum,adenoma,NS c.256G>A p.G86S 17:7674230-7674230 3
17 COSM106077247 TP53 large intestine,rectum,adenoma,NS c.523C>G p.R175G 17:7675089-7675089 3
18 COSM111758775 TP53 large intestine,colon,adenoma,NS c.733G>A p.G245S 17:7674230-7674230 3
19 COSM145021980 TP53 large intestine,colon,adenoma,NS c.524A>G p.H175R 17:7674890-7674890 3
20 COSM106455733 TP53 large intestine,rectum,adenoma,NS c.853G>C p.E285Q 17:7673767-7673767 3
21 COSM112253807 TP53 large intestine,colon,adenoma,NS c.733G>A p.G245S 17:7674230-7674230 3
22 COSM121902539 TP53 large intestine,rectum,adenoma,NS c.127C>G p.R43G 17:7675089-7675089 3
23 COSM145282365 TP53 large intestine,colon,adenoma,NS c.274A>C p.N92H 17:7675221-7675221 3
24 COSM144947428 TP53 large intestine,colon,adenoma,NS c.274A>C p.N92H 17:7675221-7675221 3
25 COSM122271749 TP53 large intestine,rectum,adenoma,NS c.337G>A p.G113S 17:7674230-7674230 3
26 COSM142560476 TP53 large intestine,colon,adenoma,NS c.616G>A p.G206S 17:7674230-7674230 3
27 COSM144106262 TP53 large intestine,rectum,adenoma,NS c.46C>G p.R16G 17:7675089-7675089 3
28 COSM142559914 TP53 large intestine,rectum,adenoma,NS c.407G>A p.R136H 17:7675088-7675088 3
29 COSM142855508 TP53 large intestine,rectum,adenoma,NS c.523C>G p.R175G 17:7675089-7675089 3
30 COSM122759329 TP53 large intestine,rectum,adenoma,NS c.127C>G p.R43G 17:7675089-7675089 3
31 COSM93184097 TP53 large intestine,colon,adenoma,NS c.916C>T p.R306* 17:7673704-7673704 3
32 COSM144351508 TP53 large intestine,colon,adenoma,NS c.820G>C p.E274Q 17:7673767-7673767 3
33 COSM143162350 TP53 large intestine,rectum,adenoma,NS c.-46G>C p.? 17:7675180-7675180 3
34 COSM122291262 TP53 large intestine,colon,adenoma,NS c.457G>C p.E153Q 17:7673767-7673767 3
35 COSM121881087 TP53 large intestine,colon,adenoma,NS c.245A>G p.H82R 17:7674890-7674890 3
36 COSM143371076 TP53 large intestine,colon,adenoma,NS c.616G>A p.G206S 17:7674230-7674230 3
37 COSM142837497 TP53 large intestine,rectum,adenoma,NS c.733G>A p.G245S 17:7674230-7674230 3
38 COSM122735329 TP53 large intestine,rectum,other,ulcerative colitis c.595C>T p.Q199* 17:7673537-7673537 3
39 COSM93183307 TP53 large intestine,rectum,adenoma,NS c.524G>A p.R175H 17:7675088-7675088 3
40 COSM143946806 TP53 large intestine,rectum,adenoma,NS c.257G>A p.G86D 17:7674229-7674229 3
41 COSM143175784 TP53 large intestine,colon,adenoma,NS c.256G>C p.G86R 17:7674230-7674230 3
42 COSM87925845 TP53 large intestine,colon,adenoma,NS c.733G>C p.G245R 17:7674230-7674230 3
43 COSM144329826 TP53 large intestine,rectum,adenoma,NS c.406C>G p.R136G 17:7675089-7675089 3
44 COSM87902864 TP53 large intestine,colon,adenoma,NS c.641A>G p.H214R 17:7674890-7674890 3
45 COSM142854442 TP53 large intestine,colon,adenoma,NS c.733G>C p.G245R 17:7674230-7674230 3
46 COSM122734486 TP53 large intestine,colon,adenoma,NS c.520C>T p.R174* 17:7673704-7673704 3
47 COSM93566065 TP53 large intestine,colon,adenoma,NS c.853G>C p.E285Q 17:7673767-7673767 3
48 COSM122271907 TP53 large intestine,colon,adenoma,NS c.520C>T p.R174* 17:7673704-7673704 3
49 COSM144016541 TP53 large intestine,rectum,adenoma,NS c.701G>A p.G234D 17:7674229-7674229 3
50 COSM143210532 TP53 large intestine,colon,adenoma,NS c.853G>C p.E285Q 17:7673767-7673767 3

Expression for Colorectal Cancer 1

Search GEO for disease gene expression data for Colorectal Cancer 1.

Pathways for Colorectal Cancer 1

Pathways related to Colorectal Cancer 1 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 MUCL1 MUC7 MUC6 MUC5B MUC5AC MUC4
2
Show member pathways
13.69 MUCL1 MUC7 MUC6 MUC5B MUC5AC MUC4
3
Show member pathways
13.03 MUCL1 MUC7 MUC6 MUC5B MUC5AC MUC4
4
Show member pathways
12.52 MUCL1 MUC7 MUC6 MUC5B MUC5AC MUC4
5
Show member pathways
12.44 MUCL1 MUC7 MUC6 MUC5B MUC5AC MUC4
6
Show member pathways
12.25 MUCL1 MUC7 MUC6 MUC5B MUC5AC MUC4
7
Show member pathways
12.2 MUCL1 MUC7 MUC6 MUC5B MUC5AC MUC4

GO Terms for Colorectal Cancer 1

Cellular components related to Colorectal Cancer 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10 MUCL1 MUC7 MUC6 MUC5B MUC5AC MUC4
2 extracellular space GO:0005615 9.97 MUC6 MUC5B MUC5AC MUC4 MUC2 MUC16
3 plasma membrane GO:0005886 9.91 MUCL1 MUC7 MUC6 MUC5B MUC5AC MUC4
4 apical plasma membrane GO:0016324 9.71 MUC20 MUC17 MUC13 MUC1
5 extracellular matrix GO:0031012 9.65 MUC6 MUC5B MUC5AC MUC4 MUC2
6 Golgi lumen GO:0005796 9.58 MUCL1 MUC7 MUC6 MUC5B MUC5AC MUC4
7 mucus layer GO:0070701 9.32 MUC5AC MUC2

Biological processes related to Colorectal Cancer 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.91 MUCL1 MUC7 MUC6 MUC5B MUC5AC MUC4
2 O-glycan processing GO:0016266 9.6 MUCL1 MUC7 MUC6 MUC5B MUC5AC MUC4
3 maintenance of gastrointestinal epithelium GO:0030277 9.46 MUC6 MUC4 MUC2 MUC13

Molecular functions related to Colorectal Cancer 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.13 MUC6 MUC5AC MUC3A
2 extracellular matrix constituent, lubricant activity GO:0030197 8.8 MUC4 MUC3A MUC17

Sources for Colorectal Cancer 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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