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CRCS10
MCID: CLR077
MIFTS: 31

Colorectal Cancer 10 (CRCS10)

Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Genetic diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes
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Aliases & Classifications for Colorectal Cancer 10

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MalaCards integrated aliases for Colorectal Cancer 10:

Name: Colorectal Cancer 10 56 73 29 6
Crcs10 56 73
Colorectal Cancer, Susceptibility to, on Chromosome 19q 56
Susceptibility to Colorectal Cancer on Chromosome 19q 73
Cancer, Colorectal, Susceptibility to, Type 10 39
Colorectal Cancer, Susceptibility to, 10 56
Colorectal Cancer on Chromosome 19q 56

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant

Miscellaneous:
onset usually before age 40 years
tumors are microsatellite stable
patients develop multiple tumors


HPO:

31
colorectal cancer 10:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Cancer diseases
Anatomical: Gastrointestinal diseases Blood diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM 56 612591
MeSH 43 D015179
MedGen 41 C2675481
Sources

Summaries for Colorectal Cancer 10

About this section
UniProtKB/Swiss-Prot : 73 Colorectal cancer 10: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.

MalaCards based summary : Colorectal Cancer 10, also known as crcs10, is related to adenoma. An important gene associated with Colorectal Cancer 10 is POLD1 (DNA Polymerase Delta 1, Catalytic Subunit). Affiliated tissues include colon, testes and lymph node, and related phenotypes are colorectal polyposis and endometrial carcinoma

More information from OMIM: 612591
Sources

Related Diseases for Colorectal Cancer 10

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Diseases in the Colorectal Cancer family:

Colorectal Cancer 1 Colorectal Cancer 2
Colorectal Cancer 3 Colorectal Cancer 5
Colorectal Cancer 6 Colorectal Cancer 7
Colorectal Cancer 8 Colorectal Cancer 9
Colorectal Cancer 10 Colorectal Cancer 11
Colorectal Cancer 12 Familial Colorectal Cancer
Familial Colorectal Cancer Type X

Diseases related to Colorectal Cancer 10 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 adenoma 9.8

Sources

Symptoms & Phenotypes for Colorectal Cancer 10

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Human phenotypes related to Colorectal Cancer 10:

31
# Description HPO Frequency HPO Source Accession
1 colorectal polyposis 31 HP:0200063
2 endometrial carcinoma 31 HP:0012114
3 carcinoma 31 HP:0030731

Symptoms via clinical synopsis from OMIM:

56
Genitourinary Internal Genitalia Female:
endometrial carcinoma

Abdomen Gastrointestinal:
colorectal adenomas
colorectal polyps
colorectal carcinoma

Neoplasia:
endometrial carcinoma
colorectal carcinoma

Clinical features from OMIM:

612591
Sources

Drugs & Therapeutics for Colorectal Cancer 10

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Search Clinical Trials , NIH Clinical Center for Colorectal Cancer 10

Sources

Genetic Tests for Colorectal Cancer 10

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Genetic tests related to Colorectal Cancer 10:

# Genetic test Affiliating Genes
1 Colorectal Cancer 10 29 POLD1
Sources

Anatomical Context for Colorectal Cancer 10

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MalaCards organs/tissues related to Colorectal Cancer 10:

40
Colon, Testes, Lymph Node, Liver, Lung
Sources

Publications for Colorectal Cancer 10

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Articles related to Colorectal Cancer 10:

(show all 46)
# Title Authors PMID Year
1
New insights into POLE and POLD1 germline mutations in familial colorectal cancer and polyposis. 56 6
24501277 2014
2
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas. 56 6
23263490 2013
3
POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillance. 56
26133394 2016
4
Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer. 6
25370038 2015
5
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. 56
19011631 2008
6
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. 56
18372905 2008
7
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. 56
18372901 2008
8
A method to select for mutator DNA polymerase deltas in Saccharomyces cerevisiae. 6
16699561 2006
9
The Relationship between Imaging-Based Body Composition Analysis and the Systemic Inflammatory Response in Patients with Cancer: A Systematic Review. 61
31487957 2019
10
Direct costs of both inpatient and outpatient care for all type cancers: The evidence from Beijing, China. 61
31062522 2019
11
Obstructing left sided colorectal cancer. A retrospective single Center study. 61
30569909 2019
12
Prognostic significance of pretreatment plasma fibrinogen level in patients with digestive system tumors: a meta-analysis. 61
29874984 2018
13
Short- and long-term outcomes following laparoscopic vs open surgery for pathological T4 colorectal cancer: 10 years of experience in a single center. 61
29358884 2018
14
The Clinical Course of Venous Thromboembolism May Differ According to Cancer Site. 61
27884650 2017
15
DNA Mismatch Repair Status Predicts Need for Future Colorectal Surgery for Metachronous Neoplasms in Young Individuals Undergoing Colorectal Cancer Resection. 61
26200678 2015
16
Surveillance colonoscopy in low-risk postpolypectomy patients: Is it necessary? 61
28840909 2015
17
The effect of chemotherapy for malignancy on the natural history of aortic aneurysm. 61
25149862 2015
18
Predictive power of quantitative and qualitative fecal immunochemical tests for hemoglobin in population screening for colorectal neoplasm. 61
23942476 2014
19
The relationship between genetic profiling, clinicopathological factors and survival in patients undergoing surgery for node-negative colorectal cancer: 10-year follow-up. 61
24072233 2013
20
Evaluation of endostatin and EGF serum levels in patients with gastric cancer. 61
22166241 2011
21
Surgical resection for lung metastases from colorectal cancer. 61
21152139 2010
22
The impact of young age on cancer-specific and non-cancer-related survival after surgery for colorectal cancer: 10-year follow-up. 61
19672260 2009
23
Clinical analysis of multiple primary malignancies in the elderly. 61
18483884 2009
24
Safety and efficacy of Y-90 microsphere treatment in patients with primary and metastatic liver cancer: the tumor selectivity of the treatment as a function of tumor to liver flow ratio. 61
17359531 2007
25
Cancer incidence in eastern Libya: the first report from the Benghazi Cancer Registry, 2003. 61
17066425 2007
26
Treatment results of colorectal cancer--10-years series of UMC Ljubljana (1991 - 2000). 61
17139895 2006
27
Urinary nucleosides as biological markers for patients with colorectal cancer. 61
15991285 2005
28
A phase II trial of gefitinib with 5-fluorouracil, leucovorin, and irinotecan in patients with colorectal cancer. 61
15870719 2005
29
DNA copy number changes at 8q11-24 in metastasized colorectal cancer. 61
15750208 2005
30
The new DR-70 immunoassay detects cancer of the gastrointestinal tract: a validation study. 61
15521846 2004
31
The CpG island methylator phenotype is not associated with a personal or family history of cancer. 61
15492290 2004
32
[Surgical treatment of colorectal cancer. 10-year experience at the INCMNSZ]. 61
12078456 2001
33
[Trends in laparoscopic surgery for colorectal cancer: 10-year experience worldwide]. 61
11260907 2001
34
[Biweekly low-dose cisplatin and 5-fluorouracil combination chemotherapy for advanced gastrointestinal carcinoma]. 61
10897212 2000
35
[Percutaneous radiofrequency ablation of hepatic metastases. Preliminary experience]. 61
10651531 1999
36
[Analysis of genomic instability by fluorescence DNA sequencer]. 61
9627490 1998
37
[Statistics of mortality in 1994 and predictions of death caused by cancer 1997]. 61
9255246 1997
38
Long-term therapy with sulphasalazine protects against colorectal cancer in ulcerative colitis: a retrospective study of colorectal cancer risk and compliance with treatment in Leicestershire. 61
8980937 1996
39
Polypectomy of adenomas in the prevention of colorectal cancer: 10 years' follow-up of the Telemark Polyp Study I. A prospective, controlled population study. 61
8898422 1996
40
Prospective adjuvant therapy with mitomycin C and carmofur (HCFU) for colorectal cancer, 10-year follow-up: Tokai HCFU Study Group, the first study for colorectal cancer. 61
8618399 1996
41
Cancer survival in Sweden during three decades, 1961-1991. 61
7492376 1995
42
[Synchronous carcinomas of the large intestine]. 61
7978768 1994
43
Radioimmunolocalization of human malignant tumors with In-111 labeled monoclonal antibody. 61
1782819 1991
44
[Regional lymph node recurrence of colorectal cancer. Considerations of etiology and therapy based on angiography findings]. 61
2044417 1991
45
Surgical resection of pulmonary metastases from colorectal cancer. 10-year follow-up. 61
2776104 1989
46
Fecal free and conjugated bile acids and neutral sterols in vegetarians, omnivores, and patients with colorectal cancer. 61
3387891 1988
Sources

Variations for Colorectal Cancer 10

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ClinVar genetic disease variations for Colorectal Cancer 10:

6 (show top 50) (show all 1099) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 POLD1 NM_002691.4(POLD1):c.1421T>C (p.Leu474Pro)SNV Pathogenic/Likely pathogenic 144003 rs587777627 19:50909701-50909701 19:50406444-50406444
2 POLD1 NM_002691.4(POLD1):c.1433G>A (p.Ser478Asn)SNV Pathogenic/Likely pathogenic 40044 rs397514632 19:50909713-50909713 19:50406456-50406456
3 POLD1 NM_002691.4(POLD1):c.583C>T (p.Arg195Ter)SNV Conflicting interpretations of pathogenicity 239357 rs377690809 19:50905375-50905375 19:50402118-50402118
4 POLD1 NM_002691.4(POLD1):c.883G>A (p.Val295Met)SNV Conflicting interpretations of pathogenicity 239373 rs199545019 19:50905911-50905911 19:50402654-50402654
5 POLD1 NM_002691.4(POLD1):c.1449C>T (p.Gly483=)SNV Conflicting interpretations of pathogenicity 239238 rs878854522 19:50909729-50909729 19:50406472-50406472
6 POLD1 NM_002691.4(POLD1):c.2007-5C>TSNV Conflicting interpretations of pathogenicity 239265 rs199506387 19:50912771-50912771 19:50409514-50409514
7 POLD1 NM_002691.4(POLD1):c.2052G>C (p.Gln684His)SNV Conflicting interpretations of pathogenicity 239269 rs144143245 19:50912821-50912821 19:50409564-50409564
8 POLD1 NM_002691.4(POLD1):c.17G>A (p.Arg6Gln)SNV Conflicting interpretations of pathogenicity 226047 rs778275831 19:50902125-50902125 19:50398868-50398868
9 POLD1 NM_002691.4(POLD1):c.455C>T (p.Ala152Val)SNV Conflicting interpretations of pathogenicity 239348 rs41563714 19:50905173-50905173 19:50401916-50401916
10 POLD1 NM_002691.4(POLD1):c.1620C>T (p.Gly540=)SNV Conflicting interpretations of pathogenicity 220890 rs140216790 19:50910365-50910365 19:50407108-50407108
11 POLD1 NM_002691.4(POLD1):c.1795G>A (p.Ala599Thr)SNV Conflicting interpretations of pathogenicity 220886 rs149569984 19:50912061-50912061 19:50408804-50408804
12 POLD1 NM_002691.4(POLD1):c.1977C>T (p.Ile659=)SNV Conflicting interpretations of pathogenicity 221165 rs45605236 19:50912463-50912463 19:50409206-50409206
13 POLD1 NM_002691.4(POLD1):c.2275G>A (p.Val759Ile)SNV Conflicting interpretations of pathogenicity 221038 rs145473716 19:50917023-50917023 19:50413766-50413766
14 POLD1 NM_002691.4(POLD1):c.2250+4G>ASNV Conflicting interpretations of pathogenicity 239278 rs370478977 19:50916782-50916782 19:50413525-50413525
15 POLD1 NM_002691.4(POLD1):c.2718-5C>TSNV Conflicting interpretations of pathogenicity 239309 rs368965066 19:50918976-50918976 19:50415719-50415719
16 POLD1 NM_002691.4(POLD1):c.3054G>A (p.Val1018=)SNV Conflicting interpretations of pathogenicity 239329 rs369613619 19:50919967-50919967 19:50416710-50416710
17 POLD1 NM_002691.4(POLD1):c.80A>T (p.Asp27Val)SNV Conflicting interpretations of pathogenicity 245862 rs150066950 19:50902188-50902188 19:50398931-50398931
18 POLD1 NM_002691.4(POLD1):c.3219-19C>ASNV Conflicting interpretations of pathogenicity 246135 rs374168125 19:50921080-50921080 19:50417823-50417823
19 POLD1 NM_002691.4(POLD1):c.495A>G (p.Gln165=)SNV Conflicting interpretations of pathogenicity 391075 rs756717437 19:50905287-50905287 19:50402030-50402030
20 POLD1 NM_002691.4(POLD1):c.2388+9C>GSNV Conflicting interpretations of pathogenicity 392655 rs1001555540 19:50917145-50917145 19:50413888-50413888
21 POLD1 NM_002691.4(POLD1):c.2757C>T (p.Gly919=)SNV Conflicting interpretations of pathogenicity 392865 rs757406292 19:50919020-50919020 19:50415763-50415763
22 POLD1 NM_002691.4(POLD1):c.2953+4C>TSNV Conflicting interpretations of pathogenicity 381766 rs1057521166 19:50919789-50919789 19:50416532-50416532
23 POLD1 NM_002691.4(POLD1):c.758+4C>TSNV Conflicting interpretations of pathogenicity 386810 rs771346692 19:50905634-50905634 19:50402377-50402377
24 POLD1 NM_002691.4(POLD1):c.2718-4G>ASNV Conflicting interpretations of pathogenicity 386591 rs755348897 19:50918977-50918977 19:50415720-50415720
25 POLD1 NM_002691.4(POLD1):c.2388+4C>TSNV Conflicting interpretations of pathogenicity 386269 rs371542643 19:50917140-50917140 19:50413883-50413883
26 POLD1 NM_002691.4(POLD1):c.3067+6C>TSNV Conflicting interpretations of pathogenicity 384592 rs1057522005 19:50919986-50919986 19:50416729-50416729
27 POLD1 NM_002691.4(POLD1):c.2429C>T (p.Ala810Val)SNV Conflicting interpretations of pathogenicity 408118 rs765981178 19:50918112-50918112 19:50414855-50414855
28 POLD1 NM_002691.4(POLD1):c.2838G>A (p.Leu946=)SNV Conflicting interpretations of pathogenicity 407988 rs1060501814 19:50919670-50919670 19:50416413-50416413
29 POLD1 NM_002691.4(POLD1):c.202+3A>GSNV Conflicting interpretations of pathogenicity 383201 rs375365167 19:50902313-50902313 19:50399056-50399056
30 POLD1 NM_002691.4(POLD1):c.55C>T (p.Arg19Cys)SNV Conflicting interpretations of pathogenicity 414765 rs368033860 19:50902163-50902163 19:50398906-50398906
31 POLD1 NM_002691.4(POLD1):c.2251-4G>ASNV Conflicting interpretations of pathogenicity 414773 rs768364989 19:50916995-50916995 19:50413738-50413738
32 POLD1 NM_002691.4(POLD1):c.3120+6_3120+21deldeletion Conflicting interpretations of pathogenicity 407973 rs1064792944 19:50920351-50920366 19:50417094-50417109
33 POLD1 NM_002691.4(POLD1):c.1384-13C>GSNV Conflicting interpretations of pathogenicity 420229 rs536467012 19:50909651-50909651 19:50406394-50406394
34 POLD1 NM_002691.4(POLD1):c.2821-4G>ASNV Conflicting interpretations of pathogenicity 469303 rs369042179 19:50919649-50919649 19:50416392-50416392
35 POLD1 NM_002691.4(POLD1):c.2433C>T (p.Gly811=)SNV Conflicting interpretations of pathogenicity 469261 rs1051057675 19:50918116-50918116 19:50414859-50414859
36 POLD1 NM_002691.4(POLD1):c.1118A>G (p.Lys373Arg)SNV Conflicting interpretations of pathogenicity 469174 rs770407151 19:50906457-50906457 19:50403200-50403200
37 POLD1 NM_002691.4(POLD1):c.99A>G (p.Gln33=)SNV Conflicting interpretations of pathogenicity 469405 rs751090809 19:50902207-50902207 19:50398950-50398950
38 POLD1 NM_002691.4(POLD1):c.3121-8G>ASNV Conflicting interpretations of pathogenicity 469325 rs762920108 19:50920421-50920421 19:50417164-50417164
39 POLD1 NM_002691.4(POLD1):c.798G>A (p.Leu266=)SNV Conflicting interpretations of pathogenicity 484338 rs1017934812 19:50905750-50905750 19:50402493-50402493
40 POLD1 NM_002691.4(POLD1):c.534G>T (p.Gly178=)SNV Conflicting interpretations of pathogenicity 484340 rs376129517 19:50905326-50905326 19:50402069-50402069
41 POLD1 NM_002691.4(POLD1):c.399G>A (p.Glu133=)SNV Conflicting interpretations of pathogenicity 484332 rs757940686 19:50905117-50905117 19:50401860-50401860
42 POLD1 NM_002691.4(POLD1):c.1527T>A (p.Ala509=)SNV Conflicting interpretations of pathogenicity 484365 rs1229053013 19:50910272-50910272 19:50407015-50407015
43 POLD1 NM_002691.4(POLD1):c.3068-5C>TSNV Conflicting interpretations of pathogenicity 484357 rs759650325 19:50920297-50920297 19:50417040-50417040
44 POLD1 NM_002691.4(POLD1):c.1687-5C>TSNV Conflicting interpretations of pathogenicity 486947 rs199733325 19:50910579-50910579 19:50407322-50407322
45 POLD1 NM_002691.4(POLD1):c.317-5C>TSNV Conflicting interpretations of pathogenicity 484366 rs768082423 19:50905030-50905030 19:50401773-50401773
46 POLD1 NM_002691.4(POLD1):c.1148C>T (p.Thr383Ile)SNV Conflicting interpretations of pathogenicity 484390 rs201654210 19:50906760-50906760 19:50403503-50403503
47 POLD1 NM_002691.4(POLD1):c.3120+6A>GSNV Conflicting interpretations of pathogenicity 516980 rs1231856737 19:50920360-50920360 19:50417103-50417103
48 POLD1 NM_002691.4(POLD1):c.1893C>G (p.Gly631=)SNV Conflicting interpretations of pathogenicity 512686 rs774216194 19:50912379-50912379 19:50409122-50409122
49 POLD1 NM_002691.4(POLD1):c.758+4C>GSNV Conflicting interpretations of pathogenicity 484337 rs771346692 19:50905634-50905634 19:50402377-50402377
50 POLD1 NM_002691.4(POLD1):c.971-5C>GSNV Conflicting interpretations of pathogenicity 537153 rs778993986 19:50906305-50906305 19:50403048-50403048

UniProtKB/Swiss-Prot genetic disease variations for Colorectal Cancer 10:

73
# Symbol AA change Variation ID SNP ID
1 POLD1 p.Ser478Asn VAR_069335 rs397514632
2 POLD1 p.Leu474Pro VAR_071966 rs587777627

Cosmic variations for Colorectal Cancer 10:

9 (show top 50) (show all 745)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM87925845 TP53 large intestine,colon,adenoma,NS c.733G>C p.G245R 17:7674230-7674230 3
2 COSM87902864 TP53 large intestine,colon,adenoma,NS c.641A>G p.H214R 17:7674890-7674890 3
3 COSM88223016 TP53 large intestine,colon,adenoma,NS c.391A>C p.N131H 17:7675221-7675221 3
4 COSM87899785 TP53 large intestine,rectum,other,ulcerative colitis c.991C>T p.Q331* 17:7673537-7673537 3
5 COSM87898578 TP53 large intestine,colon,adenoma,NS c.733G>A p.G245S 17:7674230-7674230 3
6 COSM88376117 TP53 large intestine,rectum,adenoma,NS c.853G>C p.E285Q 17:7673767-7673767 3
7 COSM87906123 TP53 large intestine,rectum,adenoma,NS c.432G>C p.Q144H 17:7675180-7675180 3
8 COSM87901765 TP53 large intestine,rectum,adenoma,NS c.734G>A p.G245D 17:7674229-7674229 3
9 COSM87927805 TP53 large intestine,rectum,adenoma,NS c.523C>G p.R175G 17:7675089-7675089 3
10 COSM87898818 TP53 large intestine,colon,adenoma,NS c.916C>T p.R306* 17:7673704-7673704 3
11 COSM87897745 TP53 large intestine,rectum,adenoma,NS c.524G>A p.R175H 17:7675088-7675088 3
12 COSM90693261 STK11 large intestine,rectum,adenoma,NS c.842C>T p.P281L 19:1221320-1221320 3
13 COSM90691966 STK11 large intestine,colon,adenoma,NS c.511G>A p.G171S 19:1220419-1220419 3
14 COSM91382025 SMAD4 large intestine,colon,adenoma,NS c.988G>C p.E330Q 18:51065455-51065455 3
15 COSM91397295 SMAD4 large intestine,rectum,other,ulcerative colitis c.1546C>T p.Q516* 18:51078354-51078354 3
16 COSM91397656 SMAD4 large intestine,colon,adenoma,NS c.1064A>C p.D355A 18:51065531-51065531 3
17 COSM91380674 SMAD4 large intestine,rectum,adenoma,NS c.1082G>A p.R361H 18:51065549-51065549 3
18 COSM86640829 RB1 large intestine,rectum,adenoma,NS c.1644A>C p.K548N 13:48381392-48381392 3
19 COSM97107772 NRAS large intestine,colon,adenoma,NS c.37G>C p.G13R 1:114716124-114716124 3
20 COSM97107359 NRAS large intestine,rectum,adenoma,NS c.182A>G p.Q61R 1:114713908-114713908 3
21 COSM85462709 MSH2 large intestine,colon,adenoma,NS c.589A>G p.K197E 2:47410316-47410316 3
22 COSM87804055 KRAS large intestine,colon,other,ulcerative colitis c.35G>T p.G12V 12:25245350-25245350 3
23 COSM87804068 KRAS large intestine,rectum,adenoma,NS c.34G>A p.G12S 12:25245351-25245351 3
24 COSM87804075 KRAS large intestine,colon,adenoma,NS c.34G>T p.G12C 12:25245351-25245351 3
25 COSM87804028 KRAS large intestine,colon,adenoma,NS c.38G>A p.G13D 12:25245347-25245347 3
26 COSM87804005 KRAS large intestine,colon,adenoma,NS c.35G>A p.G12D 12:25245350-25245350 3
27 COSM87808527 KRAS large intestine,rectum,adenoma,NS c.182A>T p.Q61L 12:25227342-25227342 3
28 COSM87805079 KRAS large intestine,rectum,adenoma,NS c.183A>C p.Q61H 12:25227341-25227341 3
29 COSM87804155 KRAS large intestine,rectum,adenoma,NS c.34G>C p.G12R 12:25245351-25245351 3
30 COSM87804083 KRAS large intestine,colon,adenoma,NS c.35G>C p.G12A 12:25245350-25245350 3
31 COSM87811077 KRAS large intestine,colon,other,ulcerative colitis c.37G>A p.G13S 12:25245348-25245348 3
32 COSM87805356 KRAS large intestine,rectum,adenoma,NS c.183A>T p.Q61H 12:25227341-25227341 3
33 COSM93760866 GNAS large intestine,rectum,adenoma,NS c.2530C>T p.R844C 20:58909365-58909365 3
34 COSM93760887 GNAS large intestine,colon,adenoma,NS c.2531G>A p.R844H 20:58909366-58909366 3
35 COSM141971230 FBXW7 large intestine,colon,adenoma,NS c.1558G>A p.D520N 4:152326092-152326092 3
36 COSM141953409 FBXW7 large intestine,rectum,adenoma,NS c.1513C>T p.R505C 4:152326137-152326137 3
37 COSM141953587 FBXW7 large intestine,colon,adenoma,NS c.832C>T p.R278* 4:152337831-152337831 3
38 COSM141954683 FBXW7 large intestine,rectum,adenoma,NS c.892C>T p.P298S 4:152332689-152332689 3
39 COSM141959845 FBXW7 large intestine,colon,adenoma,NS c.1514G>A p.R505H 4:152326136-152326136 3
40 COSM141953227 FBXW7 large intestine,colon,adenoma,NS c.1393C>T p.R465C 4:152328233-152328233 3
41 COSM141958901 FBXW7 large intestine,rectum,adenoma,NS c.1436G>T p.R479L 4:152326214-152326214 3
42 COSM141953665 FBXW7 large intestine,colon,adenoma,NS c.1394G>A p.R465H 4:152328232-152328232 3
43 COSM86757152 EGFR large intestine,colon,adenoma,NS c.1787C>T p.P596L 7:55165344-55165344 3
44 COSM150913542 CTNNB1 large intestine,colon,adenoma,NS c.134C>T p.S45F 3:41224646-41224646 3
45 COSM150913621 CTNNB1 large intestine,colon,adenoma,NS c.97T>C p.S33P 3:41224609-41224609 3
46 COSM150913795 CTNNB1 large intestine,rectum,adenoma,NS c.109T>C p.S37P 3:41224621-41224621 3
47 COSM150913536 CTNNB1 large intestine,colon,adenoma,NS c.121A>G p.T41A 3:41224633-41224633 3
48 COSM150913580 CTNNB1 large intestine,colon,adenoma,NS c.104T>G p.I35S 3:41224616-41224616 3
49 COSM150913727 CTNNB1 large intestine,colon,adenoma,NS c.101G>A p.G34E 3:41224613-41224613 3
50 COSM150913545 CTNNB1 large intestine,colon,adenoma,NS c.133T>C p.S45P 3:41224645-41224645 3
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Expression for Colorectal Cancer 10

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Search GEO for disease gene expression data for Colorectal Cancer 10.
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Pathways for Colorectal Cancer 10

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GO Terms for Colorectal Cancer 10

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Sources for Colorectal Cancer 10

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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