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CRCS10
MCID: CLR077
MIFTS: 33

Colorectal Cancer 10 (CRCS10)

Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Genetic diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes
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Aliases & Classifications for Colorectal Cancer 10

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MalaCards integrated aliases for Colorectal Cancer 10:

Name: Colorectal Cancer 10 57 73 29 6
Crcs10 57 73
Colorectal Cancer, Susceptibility to, on Chromosome 19q 57
Susceptibility to Colorectal Cancer on Chromosome 19q 73
Cancer, Colorectal, Susceptibility to, Type 10 39
Colorectal Cancer, Susceptibility to, 10 57
Colorectal Cancer on Chromosome 19q 57

Characteristics:

OMIM®:

57 (Updated 05-Mar-2021)
Inheritance:
autosomal dominant

Miscellaneous:
onset usually before age 40 years
tumors are microsatellite stable
patients develop multiple tumors


HPO:

31
colorectal cancer 10:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Cancer diseases
Anatomical: Gastrointestinal diseases Blood diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM® 57 612591
MeSH 44 D015179
MedGen 41 C2675481
Sources

Summaries for Colorectal Cancer 10

About this section
UniProtKB/Swiss-Prot : 73 Colorectal cancer 10: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.

MalaCards based summary : Colorectal Cancer 10, also known as crcs10, is related to colorectal cancer and rectum cancer. An important gene associated with Colorectal Cancer 10 is POLD1 (DNA Polymerase Delta 1, Catalytic Subunit). Affiliated tissues include colon, liver and lymph node, and related phenotypes are endometrial carcinoma and colorectal polyposis

More information from OMIM: 612591
Sources

Related Diseases for Colorectal Cancer 10

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Diseases in the Colorectal Cancer family:

Colorectal Cancer 1 Colorectal Cancer 2
Colorectal Cancer 3 Colorectal Cancer 5
Colorectal Cancer 6 Colorectal Cancer 7
Colorectal Cancer 8 Colorectal Cancer 9
Colorectal Cancer 10 Colorectal Cancer 11
Colorectal Cancer 12 Familial Colorectal Cancer
Familial Colorectal Cancer Type X

Diseases related to Colorectal Cancer 10 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 colorectal cancer 10.1
2 rectum cancer 9.9
3 adenoma 9.9

Sources

Symptoms & Phenotypes for Colorectal Cancer 10

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Human phenotypes related to Colorectal Cancer 10:

31
# Description HPO Frequency HPO Source Accession
1 endometrial carcinoma 31 HP:0012114
2 colorectal polyposis 31 HP:0200063
3 carcinoma 31 HP:0030731

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Mar-2021)
Genitourinary Internal Genitalia Female:
endometrial carcinoma

Abdomen Gastrointestinal:
colorectal adenomas
colorectal polyps
colorectal carcinoma

Neoplasia:
endometrial carcinoma
colorectal carcinoma

Clinical features from OMIM®:

612591 (Updated 05-Mar-2021)

Sources

Drugs & Therapeutics for Colorectal Cancer 10

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Search Clinical Trials , NIH Clinical Center for Colorectal Cancer 10

Sources

Genetic Tests for Colorectal Cancer 10

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Genetic tests related to Colorectal Cancer 10:

# Genetic test Affiliating Genes
1 Colorectal Cancer 10 29 POLD1
Sources

Anatomical Context for Colorectal Cancer 10

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MalaCards organs/tissues related to Colorectal Cancer 10:

40
Colon, Liver, Lymph Node, Lung
Sources

Publications for Colorectal Cancer 10

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Articles related to Colorectal Cancer 10:

(show all 46)
# Title Authors PMID Year
1
New insights into POLE and POLD1 germline mutations in familial colorectal cancer and polyposis. 6 57
24501277 2014
2
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas. 6 57
23263490 2013
3
POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillance. 57
26133394 2016
4
Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer. 6
25370038 2015
5
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. 57
19011631 2008
6
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. 57
18372905 2008
7
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. 57
18372901 2008
8
A method to select for mutator DNA polymerase deltas in Saccharomyces cerevisiae. 6
16699561 2006
9
The Relationship between Imaging-Based Body Composition Analysis and the Systemic Inflammatory Response in Patients with Cancer: A Systematic Review. 61
31487957 2019
10
Direct costs of both inpatient and outpatient care for all type cancers: The evidence from Beijing, China. 61
31062522 2019
11
Obstructing left sided colorectal cancer. A retrospective single Center study. 61
30569909 2019
12
Prognostic significance of pretreatment plasma fibrinogen level in patients with digestive system tumors: a meta-analysis. 61
29874984 2018
13
Short- and long-term outcomes following laparoscopic vs open surgery for pathological T4 colorectal cancer: 10 years of experience in a single center. 61
29358884 2018
14
The Clinical Course of Venous Thromboembolism May Differ According to Cancer Site. 61
27884650 2017
15
DNA Mismatch Repair Status Predicts Need for Future Colorectal Surgery for Metachronous Neoplasms in Young Individuals Undergoing Colorectal Cancer Resection. 61
26200678 2015
16
Surveillance colonoscopy in low-risk postpolypectomy patients: Is it necessary? 61
28840909 2015
17
The effect of chemotherapy for malignancy on the natural history of aortic aneurysm. 61
25149862 2015
18
Predictive power of quantitative and qualitative fecal immunochemical tests for hemoglobin in population screening for colorectal neoplasm. 61
23942476 2014
19
The relationship between genetic profiling, clinicopathological factors and survival in patients undergoing surgery for node-negative colorectal cancer: 10-year follow-up. 61
24072233 2013
20
Evaluation of endostatin and EGF serum levels in patients with gastric cancer. 61
22166241 2011
21
Surgical resection for lung metastases from colorectal cancer. 61
21152139 2010
22
The impact of young age on cancer-specific and non-cancer-related survival after surgery for colorectal cancer: 10-year follow-up. 61
19672260 2009
23
Clinical analysis of multiple primary malignancies in the elderly. 61
18483884 2009
24
Safety and efficacy of Y-90 microsphere treatment in patients with primary and metastatic liver cancer: the tumor selectivity of the treatment as a function of tumor to liver flow ratio. 61
17359531 2007
25
Cancer incidence in eastern Libya: the first report from the Benghazi Cancer Registry, 2003. 61
17066425 2007
26
Treatment results of colorectal cancer--10-years series of UMC Ljubljana (1991 - 2000). 61
17139895 2006
27
Urinary nucleosides as biological markers for patients with colorectal cancer. 61
15991285 2005
28
A phase II trial of gefitinib with 5-fluorouracil, leucovorin, and irinotecan in patients with colorectal cancer. 61
15870719 2005
29
DNA copy number changes at 8q11-24 in metastasized colorectal cancer. 61
15750208 2005
30
The new DR-70 immunoassay detects cancer of the gastrointestinal tract: a validation study. 61
15521846 2004
31
The CpG island methylator phenotype is not associated with a personal or family history of cancer. 61
15492290 2004
32
[Surgical treatment of colorectal cancer. 10-year experience at the INCMNSZ]. 61
12078456 2001
33
[Trends in laparoscopic surgery for colorectal cancer: 10-year experience worldwide]. 61
11260907 2001
34
[Biweekly low-dose cisplatin and 5-fluorouracil combination chemotherapy for advanced gastrointestinal carcinoma]. 61
10897212 2000
35
[Percutaneous radiofrequency ablation of hepatic metastases. Preliminary experience]. 61
10651531 1999
36
[Analysis of genomic instability by fluorescence DNA sequencer]. 61
9627490 1998
37
[Statistics of mortality in 1994 and predictions of death caused by cancer 1997]. 61
9255246 1997
38
Long-term therapy with sulphasalazine protects against colorectal cancer in ulcerative colitis: a retrospective study of colorectal cancer risk and compliance with treatment in Leicestershire. 61
8980937 1996
39
Polypectomy of adenomas in the prevention of colorectal cancer: 10 years' follow-up of the Telemark Polyp Study I. A prospective, controlled population study. 61
8898422 1996
40
Prospective adjuvant therapy with mitomycin C and carmofur (HCFU) for colorectal cancer, 10-year follow-up: Tokai HCFU Study Group, the first study for colorectal cancer. 61
8618399 1996
41
Cancer survival in Sweden during three decades, 1961-1991. 61
7492376 1995
42
[Synchronous carcinomas of the large intestine]. 61
7978768 1994
43
Radioimmunolocalization of human malignant tumors with In-111 labeled monoclonal antibody. 61
1782819 1991
44
[Regional lymph node recurrence of colorectal cancer. Considerations of etiology and therapy based on angiography findings]. 61
2044417 1991
45
Surgical resection of pulmonary metastases from colorectal cancer. 10-year follow-up. 61
2776104 1989
46
Fecal free and conjugated bile acids and neutral sterols in vegetarians, omnivores, and patients with colorectal cancer. 61
3387891 1988
Sources

Variations for Colorectal Cancer 10

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ClinVar genetic disease variations for Colorectal Cancer 10:

6 (show top 50) (show all 1799)
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 POLD1 NM_002691.4(POLD1):c.1809_1811CTC[1] (p.Ser605del) Microsatellite Pathogenic 60775 rs398122386 19:50912075-50912077 19:50408818-50408820
2 POLD1 NM_002691.4(POLD1):c.1433G>A (p.Ser478Asn) SNV Pathogenic/Likely pathogenic 40044 rs397514632 19:50909713-50909713 19:50406456-50406456
3 POLD1 NM_002691.4(POLD1):c.1421T>C (p.Leu474Pro) SNV Likely pathogenic 144003 rs587777627 19:50909701-50909701 19:50406444-50406444
4 POLD1 NM_002691.4(POLD1):c.961G>A (p.Gly321Ser) SNV Conflicting interpretations of pathogenicity 221136 rs41554817 19:50905989-50905989 19:50402732-50402732
5 POLD1 NM_002691.4(POLD1):c.583C>T (p.Arg195Ter) SNV Conflicting interpretations of pathogenicity 239357 rs377690809 19:50905375-50905375 19:50402118-50402118
6 POLD1 NM_002691.4(POLD1):c.2433C>T (p.Gly811=) SNV Conflicting interpretations of pathogenicity 469261 rs1051057675 19:50918116-50918116 19:50414859-50414859
7 POLD1 NM_002691.4(POLD1):c.3120+6A>G SNV Conflicting interpretations of pathogenicity 516980 rs1231856737 19:50920360-50920360 19:50417103-50417103
8 POLD1 NM_002691.4(POLD1):c.455C>T (p.Ala152Val) SNV Conflicting interpretations of pathogenicity 239348 rs41563714 19:50905173-50905173 19:50401916-50401916
9 POLD1 NM_002691.4(POLD1):c.1795G>A (p.Ala599Thr) SNV Conflicting interpretations of pathogenicity 220886 rs149569984 19:50912061-50912061 19:50408804-50408804
10 POLD1 NM_002691.4(POLD1):c.2275G>A (p.Val759Ile) SNV Conflicting interpretations of pathogenicity 221038 rs145473716 19:50917023-50917023 19:50413766-50413766
11 POLD1 NM_002691.4(POLD1):c.208G>T (p.Val70Phe) SNV Conflicting interpretations of pathogenicity 225288 rs147911699 19:50902633-50902633 19:50399376-50399376
12 POLD1 NM_002691.4(POLD1):c.2052G>C (p.Gln684His) SNV Conflicting interpretations of pathogenicity 239269 rs144143245 19:50912821-50912821 19:50409564-50409564
13 POLD1 NM_002691.4(POLD1):c.55C>T (p.Arg19Cys) SNV Conflicting interpretations of pathogenicity 414765 rs368033860 19:50902163-50902163 19:50398906-50398906
14 POLD1 NM_002691.4(POLD1):c.1786G>A (p.Val596Ile) SNV Uncertain significance 408030 rs773180520 19:50912052-50912052 19:50408795-50408795
15 POLD1 NM_002691.4(POLD1):c.3073G>A (p.Val1025Met) SNV Uncertain significance 408116 rs1060501858 19:50920307-50920307 19:50417050-50417050
16 POLD1 NM_002691.4(POLD1):c.1371G>T (p.Met457Ile) SNV Uncertain significance 469193 rs1457008478 19:50909567-50909567 19:50406310-50406310
17 POLD1 NM_002691.4(POLD1):c.269A>G (p.Gln90Arg) SNV Uncertain significance 469286 rs778838312 19:50902694-50902694 19:50399437-50399437
18 POLD1 NM_002691.4(POLD1):c.358G>C (p.Gly120Arg) SNV Uncertain significance 469346 rs746234949 19:50905076-50905076 19:50401819-50401819
19 POLD1 NM_002691.4(POLD1):c.758G>A (p.Arg253Gln) SNV Uncertain significance 469383 rs1366413924 19:50905630-50905630 19:50402373-50402373
20 POLD1 NM_002691.4(POLD1):c.980C>T (p.Pro327Leu) SNV Uncertain significance 40045 rs397514633 19:50906319-50906319 19:50403062-50403062
21 POLD1 NM_002691.4(POLD1):c.520C>T (p.Arg174Trp) SNV Uncertain significance 239351 rs749334182 19:50905312-50905312 19:50402055-50402055
22 POLD1 NM_002691.4(POLD1):c.224T>C (p.Ile75Thr) SNV Uncertain significance 239277 rs878854534 19:50902649-50902649 19:50399392-50399392
23 POLD1 NM_002691.4(POLD1):c.3016G>A (p.Ala1006Thr) SNV Uncertain significance 408069 rs376197467 19:50919929-50919929 19:50416672-50416672
24 POLD1 NM_002691.4(POLD1):c.132G>A (p.Met44Ile) SNV Uncertain significance 407954 rs757575448 19:50902240-50902240 19:50398983-50398983
25 POLD1 NM_002691.4(POLD1):c.2178G>C (p.Gln726His) SNV Uncertain significance 246171 rs747483140 19:50916706-50916706 19:50413449-50413449
26 POLD1 NM_002691.4(POLD1):c.2972G>A (p.Cys991Tyr) SNV Uncertain significance 619714 rs775264944 19:50919885-50919885 19:50416628-50416628
27 POLD1 NM_002691.4(POLD1):c.1775+6del Deletion Uncertain significance 537154 rs1555791538 19:50910677-50910677 19:50407420-50407420
28 POLD1 NM_002691.4(POLD1):c.3068-3C>T SNV Uncertain significance 537169 rs1555793559 19:50920299-50920299 19:50417042-50417042
29 POLD1 NM_002691.4(POLD1):c.1686+3C>T SNV Uncertain significance 537170 rs1555791459 19:50910434-50910434 19:50407177-50407177
30 POLD1 NM_002691.4(POLD1):c.49C>T (p.Arg17Trp) SNV Uncertain significance 408109 rs570461545 19:50902157-50902157 19:50398900-50398900
31 POLD1 NM_002691.4(POLD1):c.3136G>T (p.Ala1046Ser) SNV Uncertain significance 407978 rs751088347 19:50920444-50920444 19:50417187-50417187
32 POLD1 NM_002691.4(POLD1):c.530G>A (p.Arg177His) SNV Uncertain significance 469360 rs3218750 19:50905322-50905322 19:50402065-50402065
33 POLD1 NM_002691.4(POLD1):c.584G>A (p.Arg195Gln) SNV Uncertain significance 469368 rs1555789938 19:50905376-50905376 19:50402119-50402119
34 POLD1 NM_002691.4(POLD1):c.1681C>T (p.Arg561Trp) SNV Uncertain significance 469212 rs368738479 19:50910426-50910426 19:50407169-50407169
35 POLD1 NM_002691.4(POLD1):c.241C>T (p.Arg81Trp) SNV Uncertain significance 560820 rs752124373 19:50902666-50902666 19:50399409-50399409
36 POLD1 NM_002691.4(POLD1):c.866A>G (p.Asp289Gly) SNV Uncertain significance 239371 rs878854558 19:50905894-50905894 19:50402637-50402637
37 POLD1 NM_002691.4(POLD1):c.1955G>A (p.Arg652Gln) SNV Uncertain significance 239262 rs778037523 19:50912441-50912441 19:50409184-50409184
38 POLD1 NM_002691.4(POLD1):c.203G>A (p.Gly68Glu) SNV Uncertain significance 239267 rs144707871 19:50902628-50902628 19:50399371-50399371
39 POLD1 NM_002691.4(POLD1):c.2797G>T (p.Val933Leu) SNV Uncertain significance 469301 rs764785216 19:50919060-50919060 19:50415803-50415803
40 POLD1 NM_002691.4(POLD1):c.632G>A (p.Arg211His) SNV Uncertain significance 439259 rs373192520 19:50905504-50905504 19:50402247-50402247
41 POLD1 NM_002691.4(POLD1):c.868G>A (p.Val290Met) SNV Uncertain significance 505437 rs748657880 19:50905896-50905896 19:50402639-50402639
42 POLD1 NM_002691.4(POLD1):c.3023G>A (p.Arg1008His) SNV Uncertain significance 517284 rs763747258 19:50919936-50919936 19:50416679-50416679
43 POLD1 NM_002691.4(POLD1):c.203G>A (p.Gly68Glu) SNV Uncertain significance 239267 rs144707871 19:50902628-50902628 19:50399371-50399371
44 POLD1 NM_002691.4(POLD1):c.1735G>A (p.Glu579Lys) SNV Uncertain significance 505438 rs1354117345 19:50910632-50910632 19:50407375-50407375
45 POLD1 NM_002691.4(POLD1):c.2154+2T>C SNV Uncertain significance 505439 rs1555792026 19:50912925-50912925 19:50409668-50409668
46 POLD1 NM_002691.3(POLD1):c.589_589+1delAG Microsatellite Uncertain significance 408043 rs1060501829 19:50905376-50905377 19:50402119-50402120
47 POLD1 NM_001256849.1(POLD1):c.2959dup (p.Asp987Glyfs) Duplication Uncertain significance 537052 rs756872503 19:50919865-50919866 19:50416608-50416609
48 POLD1 NC_000019.10:g.50416615del Deletion Uncertain significance 935838 19:50919866-50919866 19:50416609-50416609
49 POLD1 NM_002691.4(POLD1):c.3120+6_3120+21del Deletion Uncertain significance 407973 rs1064792944 19:50920351-50920366 19:50417094-50417109
50 POLD1 NM_002691.4(POLD1):c.2807A>C (p.Tyr936Ser) SNV Uncertain significance 569400 rs1568638877 19:50919070-50919070 19:50415813-50415813

UniProtKB/Swiss-Prot genetic disease variations for Colorectal Cancer 10:

73
# Symbol AA change Variation ID SNP ID
1 POLD1 p.Ser478Asn VAR_069335 rs397514632
2 POLD1 p.Leu474Pro VAR_071966 rs587777627

Cosmic variations for Colorectal Cancer 10:

9 (show top 50) (show all 745)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM93183877 TP53 large intestine,colon,adenoma,NS c.733G>A p.G245S 17:7674230-7674230 3
2 COSM112254813 TP53 large intestine,rectum,other,ulcerative colitis c.991C>T p.Q331* 17:7673537-7673537 3
3 COSM121879912 TP53 large intestine,rectum,adenoma,NS c.338G>A p.G113D 17:7674229-7674229 3
4 COSM144013587 TP53 large intestine,rectum,adenoma,NS c.700G>A p.G234S 17:7674230-7674230 3
5 COSM142564162 TP53 large intestine,colon,adenoma,NS c.524A>G p.H175R 17:7674890-7674890 3
6 COSM144314088 TP53 large intestine,colon,adenoma,NS c.-87A>C p.? 17:7675221-7675221 3
7 COSM144651337 TP53 large intestine,rectum,adenoma,NS c.616G>A p.G206S 17:7674230-7674230 3
8 COSM144104972 TP53 large intestine,colon,adenoma,NS c.256G>C p.G86R 17:7674230-7674230 3
9 COSM144654651 TP53 large intestine,rectum,adenoma,NS c.617G>A p.G206D 17:7674229-7674229 3
10 COSM122567711 TP53 large intestine,colon,adenoma,NS c.-6A>C p.? 17:7675221-7675221 3
11 COSM144087932 TP53 large intestine,rectum,other,ulcerative colitis c.514C>T p.Q172* 17:7673537-7673537 3
12 COSM144014702 TP53 large intestine,rectum,other,ulcerative colitis c.958C>T p.Q320* 17:7673537-7673537 3
13 COSM121876212 TP53 large intestine,colon,adenoma,NS c.337G>A p.G113S 17:7674230-7674230 3
14 COSM143943997 TP53 large intestine,colon,adenoma,NS c.256G>A p.G86S 17:7674230-7674230 3
15 COSM145017865 TP53 large intestine,colon,adenoma,NS c.616G>A p.G206S 17:7674230-7674230 3
16 COSM143156960 TP53 large intestine,rectum,adenoma,NS c.256G>A p.G86S 17:7674230-7674230 3
17 COSM106077247 TP53 large intestine,rectum,adenoma,NS c.523C>G p.R175G 17:7675089-7675089 3
18 COSM111758775 TP53 large intestine,colon,adenoma,NS c.733G>A p.G245S 17:7674230-7674230 3
19 COSM145021980 TP53 large intestine,colon,adenoma,NS c.524A>G p.H175R 17:7674890-7674890 3
20 COSM106455733 TP53 large intestine,rectum,adenoma,NS c.853G>C p.E285Q 17:7673767-7673767 3
21 COSM112253807 TP53 large intestine,colon,adenoma,NS c.733G>A p.G245S 17:7674230-7674230 3
22 COSM121902539 TP53 large intestine,rectum,adenoma,NS c.127C>G p.R43G 17:7675089-7675089 3
23 COSM145282365 TP53 large intestine,colon,adenoma,NS c.274A>C p.N92H 17:7675221-7675221 3
24 COSM144947428 TP53 large intestine,colon,adenoma,NS c.274A>C p.N92H 17:7675221-7675221 3
25 COSM122271749 TP53 large intestine,rectum,adenoma,NS c.337G>A p.G113S 17:7674230-7674230 3
26 COSM142560476 TP53 large intestine,colon,adenoma,NS c.616G>A p.G206S 17:7674230-7674230 3
27 COSM144106262 TP53 large intestine,rectum,adenoma,NS c.46C>G p.R16G 17:7675089-7675089 3
28 COSM142559914 TP53 large intestine,rectum,adenoma,NS c.407G>A p.R136H 17:7675088-7675088 3
29 COSM142855508 TP53 large intestine,rectum,adenoma,NS c.523C>G p.R175G 17:7675089-7675089 3
30 COSM122759329 TP53 large intestine,rectum,adenoma,NS c.127C>G p.R43G 17:7675089-7675089 3
31 COSM93184097 TP53 large intestine,colon,adenoma,NS c.916C>T p.R306* 17:7673704-7673704 3
32 COSM144351508 TP53 large intestine,colon,adenoma,NS c.820G>C p.E274Q 17:7673767-7673767 3
33 COSM143162350 TP53 large intestine,rectum,adenoma,NS c.-46G>C p.? 17:7675180-7675180 3
34 COSM122291262 TP53 large intestine,colon,adenoma,NS c.457G>C p.E153Q 17:7673767-7673767 3
35 COSM121881087 TP53 large intestine,colon,adenoma,NS c.245A>G p.H82R 17:7674890-7674890 3
36 COSM143371076 TP53 large intestine,colon,adenoma,NS c.616G>A p.G206S 17:7674230-7674230 3
37 COSM142837497 TP53 large intestine,rectum,adenoma,NS c.733G>A p.G245S 17:7674230-7674230 3
38 COSM122735329 TP53 large intestine,rectum,other,ulcerative colitis c.595C>T p.Q199* 17:7673537-7673537 3
39 COSM93183307 TP53 large intestine,rectum,adenoma,NS c.524G>A p.R175H 17:7675088-7675088 3
40 COSM143946806 TP53 large intestine,rectum,adenoma,NS c.257G>A p.G86D 17:7674229-7674229 3
41 COSM143175784 TP53 large intestine,colon,adenoma,NS c.256G>C p.G86R 17:7674230-7674230 3
42 COSM87925845 TP53 large intestine,colon,adenoma,NS c.733G>C p.G245R 17:7674230-7674230 3
43 COSM144329826 TP53 large intestine,rectum,adenoma,NS c.406C>G p.R136G 17:7675089-7675089 3
44 COSM87902864 TP53 large intestine,colon,adenoma,NS c.641A>G p.H214R 17:7674890-7674890 3
45 COSM142854442 TP53 large intestine,colon,adenoma,NS c.733G>C p.G245R 17:7674230-7674230 3
46 COSM122734486 TP53 large intestine,colon,adenoma,NS c.520C>T p.R174* 17:7673704-7673704 3
47 COSM93566065 TP53 large intestine,colon,adenoma,NS c.853G>C p.E285Q 17:7673767-7673767 3
48 COSM122271907 TP53 large intestine,colon,adenoma,NS c.520C>T p.R174* 17:7673704-7673704 3
49 COSM144016541 TP53 large intestine,rectum,adenoma,NS c.701G>A p.G234D 17:7674229-7674229 3
50 COSM143210532 TP53 large intestine,colon,adenoma,NS c.853G>C p.E285Q 17:7673767-7673767 3
Sources

Expression for Colorectal Cancer 10

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Search GEO for disease gene expression data for Colorectal Cancer 10.
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Pathways for Colorectal Cancer 10

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GO Terms for Colorectal Cancer 10

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Sources for Colorectal Cancer 10

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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