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CRCS10
MCID: CLR077
MIFTS: 33

Colorectal Cancer 10 (CRCS10)

Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Genetic diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes
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Aliases & Classifications for Colorectal Cancer 10

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MalaCards integrated aliases for Colorectal Cancer 10:

Name: Colorectal Cancer 10 57 74 29 6
Crcs10 57 74
Colorectal Cancer, Susceptibility to, on Chromosome 19q 57
Susceptibility to Colorectal Cancer on Chromosome 19q 74
Cancer, Colorectal, Susceptibility to, Type 10 40
Colorectal Cancer, Susceptibility to, 10 57
Colorectal Cancer on Chromosome 19q 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
onset usually before age 40 years
tumors are microsatellite stable
patients develop multiple tumors


HPO:

32
colorectal cancer 10:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Global: Genetic diseases Cancer diseases Rare diseases
Anatomical: Gastrointestinal diseases Blood diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM 57 612591
MeSH 44 D015179
MedGen 42 C2675481
Sources

Summaries for Colorectal Cancer 10

About this section
UniProtKB/Swiss-Prot : 74 Colorectal cancer 10: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.

MalaCards based summary : Colorectal Cancer 10, also known as crcs10, is related to adenoma. An important gene associated with Colorectal Cancer 10 is POLD1 (DNA Polymerase Delta 1, Catalytic Subunit). Affiliated tissues include colon, testes and liver, and related phenotypes are colorectal polyposis and endometrial carcinoma

More information from OMIM: 612591
Sources

Related Diseases for Colorectal Cancer 10

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Diseases in the Colorectal Cancer family:

Colorectal Cancer 1 Colorectal Cancer 2
Colorectal Cancer 3 Colorectal Cancer 5
Colorectal Cancer 6 Colorectal Cancer 7
Colorectal Cancer 8 Colorectal Cancer 9
Colorectal Cancer 10 Colorectal Cancer 11
Colorectal Cancer 12 Familial Colorectal Cancer
Familial Colorectal Cancer Type X

Diseases related to Colorectal Cancer 10 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 adenoma 9.8

Sources

Symptoms & Phenotypes for Colorectal Cancer 10

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Human phenotypes related to Colorectal Cancer 10:

32
# Description HPO Frequency HPO Source Accession
1 colorectal polyposis 32 HP:0200063
2 endometrial carcinoma 32 HP:0012114
3 carcinoma 32 HP:0030731

Symptoms via clinical synopsis from OMIM:

57
Genitourinary Internal Genitalia Female:
endometrial carcinoma

Abdomen Gastrointestinal:
colorectal adenomas
colorectal polyps
colorectal carcinoma

Neoplasia:
endometrial carcinoma
colorectal carcinoma

Clinical features from OMIM:

612591
Sources

Drugs & Therapeutics for Colorectal Cancer 10

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Search Clinical Trials , NIH Clinical Center for Colorectal Cancer 10

Sources

Genetic Tests for Colorectal Cancer 10

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Genetic tests related to Colorectal Cancer 10:

# Genetic test Affiliating Genes
1 Colorectal Cancer 10 29 POLD1
Sources

Anatomical Context for Colorectal Cancer 10

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MalaCards organs/tissues related to Colorectal Cancer 10:

41
Colon, Testes, Liver, Lung, Lymph Node
Sources

Publications for Colorectal Cancer 10

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Articles related to Colorectal Cancer 10:

(show all 45)
# Title Authors PMID Year
1
New insights into POLE and POLD1 germline mutations in familial colorectal cancer and polyposis. 8 71
24501277 2014
2
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas. 8 71
23263490 2013
3
POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillance. 8
26133394 2016
4
Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer. 71
25370038 2015
5
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. 8
19011631 2008
6
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. 8
18372905 2008
7
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. 8
18372901 2008
8
A method to select for mutator DNA polymerase deltas in Saccharomyces cerevisiae. 71
16699561 2006
9
Direct costs of both inpatient and outpatient care for all type cancers: The evidence from Beijing, China. 38
31062522 2019
10
Obstructing left sided colorectal cancer. A retrospective single Center study. 38
30569909 2019
11
Prognostic significance of pretreatment plasma fibrinogen level in patients with digestive system tumors: a meta-analysis. 38
29874984 2018
12
Short- and long-term outcomes following laparoscopic vs open surgery for pathological T4 colorectal cancer: 10 years of experience in a single center. 38
29358884 2018
13
The Clinical Course of Venous Thromboembolism May Differ According to Cancer Site. 38
27884650 2017
14
DNA Mismatch Repair Status Predicts Need for Future Colorectal Surgery for Metachronous Neoplasms in Young Individuals Undergoing Colorectal Cancer Resection. 38
26200678 2015
15
Surveillance colonoscopy in low-risk postpolypectomy patients: Is it necessary? 38
28840909 2015
16
The effect of chemotherapy for malignancy on the natural history of aortic aneurysm. 38
25149862 2015
17
Predictive power of quantitative and qualitative fecal immunochemical tests for hemoglobin in population screening for colorectal neoplasm. 38
23942476 2014
18
The relationship between genetic profiling, clinicopathological factors and survival in patients undergoing surgery for node-negative colorectal cancer: 10-year follow-up. 38
24072233 2013
19
Evaluation of endostatin and EGF serum levels in patients with gastric cancer. 38
22166241 2011
20
Surgical resection for lung metastases from colorectal cancer. 38
21152139 2010
21
The impact of young age on cancer-specific and non-cancer-related survival after surgery for colorectal cancer: 10-year follow-up. 38
19672260 2009
22
Clinical analysis of multiple primary malignancies in the elderly. 38
18483884 2009
23
Safety and efficacy of Y-90 microsphere treatment in patients with primary and metastatic liver cancer: the tumor selectivity of the treatment as a function of tumor to liver flow ratio. 38
17359531 2007
24
Cancer incidence in eastern Libya: the first report from the Benghazi Cancer Registry, 2003. 38
17066425 2007
25
Treatment results of colorectal cancer--10-years series of UMC Ljubljana (1991 - 2000). 38
17139895 2006
26
Urinary nucleosides as biological markers for patients with colorectal cancer. 38
15991285 2005
27
A phase II trial of gefitinib with 5-fluorouracil, leucovorin, and irinotecan in patients with colorectal cancer. 38
15870719 2005
28
DNA copy number changes at 8q11-24 in metastasized colorectal cancer. 38
15750208 2005
29
The new DR-70 immunoassay detects cancer of the gastrointestinal tract: a validation study. 38
15521846 2004
30
The CpG island methylator phenotype is not associated with a personal or family history of cancer. 38
15492290 2004
31
[Surgical treatment of colorectal cancer. 10-year experience at the INCMNSZ]. 38
12078456 2001
32
[Trends in laparoscopic surgery for colorectal cancer: 10-year experience worldwide]. 38
11260907 2001
33
[Biweekly low-dose cisplatin and 5-fluorouracil combination chemotherapy for advanced gastrointestinal carcinoma]. 38
10897212 2000
34
[Percutaneous radiofrequency ablation of hepatic metastases. Preliminary experience]. 38
10651531 1999
35
[Analysis of genomic instability by fluorescence DNA sequencer]. 38
9627490 1998
36
[Statistics of mortality in 1994 and predictions of death caused by cancer 1997]. 38
9255246 1997
37
Long-term therapy with sulphasalazine protects against colorectal cancer in ulcerative colitis: a retrospective study of colorectal cancer risk and compliance with treatment in Leicestershire. 38
8980937 1996
38
Polypectomy of adenomas in the prevention of colorectal cancer: 10 years' follow-up of the Telemark Polyp Study I. A prospective, controlled population study. 38
8898422 1996
39
Prospective adjuvant therapy with mitomycin C and carmofur (HCFU) for colorectal cancer, 10-year follow-up: Tokai HCFU Study Group, the first study for colorectal cancer. 38
8618399 1996
40
Cancer survival in Sweden during three decades, 1961-1991. 38
7492376 1995
41
[Synchronous carcinomas of the large intestine]. 38
7978768 1994
42
Radioimmunolocalization of human malignant tumors with In-111 labeled monoclonal antibody. 38
1782819 1991
43
[Regional lymph node recurrence of colorectal cancer. Considerations of etiology and therapy based on angiography findings]. 38
2044417 1991
44
Surgical resection of pulmonary metastases from colorectal cancer. 10-year follow-up. 38
2776104 1989
45
Fecal free and conjugated bile acids and neutral sterols in vegetarians, omnivores, and patients with colorectal cancer. 38
3387891 1988
Sources

Variations for Colorectal Cancer 10

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ClinVar genetic disease variations for Colorectal Cancer 10:

6 (show top 50) (show all 1381)
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 POLD1 NM_001256849.1(POLD1): c.1433G> A (p.Ser478Asn) single nucleotide variant Pathogenic/Likely pathogenic rs397514632 19:50909713-50909713 19:50406456-50406456
2 POLD1 NM_001256849.1(POLD1): c.1421T> C (p.Leu474Pro) single nucleotide variant Pathogenic/Likely pathogenic rs587777627 19:50909701-50909701 19:50406444-50406444
3 POLD1 NM_001256849.1(POLD1): c.371T> C (p.Val124Ala) single nucleotide variant Conflicting interpretations of pathogenicity rs199993010 19:50905089-50905089 19:50401832-50401832
4 POLD1 NM_001256849.1(POLD1): c.1795G> A (p.Ala599Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs149569984 19:50912061-50912061 19:50408804-50408804
5 POLD1 NM_001256849.1(POLD1): c.2100A> G (p.Val700=) single nucleotide variant Conflicting interpretations of pathogenicity rs772468675 19:50912869-50912869 19:50409612-50409612
6 POLD1 NM_001256849.1(POLD1): c.2275G> A (p.Val759Ile) single nucleotide variant Conflicting interpretations of pathogenicity rs145473716 19:50917023-50917023 19:50413766-50413766
7 POLD1 NM_001256849.1(POLD1): c.17G> A (p.Arg6Gln) single nucleotide variant Conflicting interpretations of pathogenicity rs778275831 19:50902125-50902125 19:50398868-50398868
8 POLD1 NM_001256849.1(POLD1): c.13C> T (p.Arg5Trp) single nucleotide variant Conflicting interpretations of pathogenicity rs9282830 19:50902121-50902121 19:50398864-50398864
9 POLD1 NM_001256849.1(POLD1): c.208G> A (p.Val70Ile) single nucleotide variant Conflicting interpretations of pathogenicity rs147911699 19:50902633-50902633 19:50399376-50399376
10 POLD1 NM_001256849.1(POLD1): c.455C> T (p.Ala152Val) single nucleotide variant Conflicting interpretations of pathogenicity rs41563714 19:50905173-50905173 19:50401916-50401916
11 POLD1 NM_001256849.1(POLD1): c.534G> T (p.Gly178=) single nucleotide variant Conflicting interpretations of pathogenicity rs376129517 19:50905326-50905326 19:50402069-50402069
12 POLD1 NM_001256849.1(POLD1): c.399G> A (p.Glu133=) single nucleotide variant Conflicting interpretations of pathogenicity rs757940686 19:50905117-50905117 19:50401860-50401860
13 POLD1 NM_001256849.1(POLD1): c.735G> A (p.Glu245=) single nucleotide variant Conflicting interpretations of pathogenicity rs745841154 19:50905607-50905607 19:50402350-50402350
14 POLD1 NM_001256849.1(POLD1): c.798G> A (p.Leu266=) single nucleotide variant Conflicting interpretations of pathogenicity rs1017934812 19:50905750-50905750 19:50402493-50402493
15 POLD1 NM_001256849.1(POLD1): c.2251-5C> T single nucleotide variant Conflicting interpretations of pathogenicity rs1236954722 19:50916994-50916994 19:50413737-50413737
16 POLD1 NM_001256849.1(POLD1): c.1527T> A (p.Ala509=) single nucleotide variant Conflicting interpretations of pathogenicity rs1229053013 19:50910272-50910272 19:50407015-50407015
17 POLD1 NM_001256849.1(POLD1): c.3068-5C> T single nucleotide variant Conflicting interpretations of pathogenicity rs759650325 19:50920297-50920297 19:50417040-50417040
18 POLD1 NM_001256849.1(POLD1): c.1687-5C> T single nucleotide variant Conflicting interpretations of pathogenicity rs199733325 19:50910579-50910579 19:50407322-50407322
19 POLD1 NM_001256849.1(POLD1): c.317-5C> T single nucleotide variant Conflicting interpretations of pathogenicity rs768082423 19:50905030-50905030 19:50401773-50401773
20 POLD1 NM_001256849.1(POLD1): c.971-5C> T single nucleotide variant Conflicting interpretations of pathogenicity rs778993986 19:50906305-50906305 19:50403048-50403048
21 POLD1 NM_001256849.1(POLD1): c.1148C> T (p.Thr383Ile) single nucleotide variant Conflicting interpretations of pathogenicity rs201654210 19:50906760-50906760 19:50403503-50403503
22 POLD1 NM_001256849.1(POLD1): c.3120+6A> G single nucleotide variant Conflicting interpretations of pathogenicity rs1231856737 19:50920360-50920360 19:50417103-50417103
23 POLD1 NM_001256849.1(POLD1): c.1893C> G (p.Gly631=) single nucleotide variant Conflicting interpretations of pathogenicity rs774216194 19:50912379-50912379 19:50409122-50409122
24 POLD1 NM_001256849.1(POLD1): c.840+10T> C single nucleotide variant Conflicting interpretations of pathogenicity rs1555790184 19:50905802-50905802 19:50402545-50402545
25 POLD1 NM_001256849.1(POLD1): c.589A> C (p.Ser197Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs1040524947 19:50905381-50905381 19:50402124-50402124
26 POLD1 NM_001256849.1(POLD1): c.3219-19C> A single nucleotide variant Conflicting interpretations of pathogenicity rs374168125 19:50921080-50921080 19:50417823-50417823
27 POLD1 NM_001256849.1(POLD1): c.495A> G (p.Gln165=) single nucleotide variant Conflicting interpretations of pathogenicity rs756717437 19:50905287-50905287 19:50402030-50402030
28 POLD1 NM_001256849.1(POLD1): c.841-10A> G single nucleotide variant Conflicting interpretations of pathogenicity rs140160345 19:50905859-50905859 19:50402602-50402602
29 POLD1 NM_001256849.1(POLD1): c.2388+9C> G single nucleotide variant Conflicting interpretations of pathogenicity rs1001555540 19:50917145-50917145 19:50413888-50413888
30 POLD1 NM_001256849.1(POLD1): c.758+4C> T single nucleotide variant Conflicting interpretations of pathogenicity rs771346692 19:50905634-50905634 19:50402377-50402377
31 POLD1 NM_001256849.1(POLD1): c.3204C> T (p.Asp1068=) single nucleotide variant Conflicting interpretations of pathogenicity rs759019419 19:50920512-50920512 19:50417255-50417255
32 POLD1 NM_001256849.1(POLD1): c.3258G> C (p.Arg1086=) single nucleotide variant Conflicting interpretations of pathogenicity rs776167760 19:50921138-50921138 19:50417881-50417881
33 POLD1 NM_001256849.1(POLD1): c.2757C> T (p.Gly919=) single nucleotide variant Conflicting interpretations of pathogenicity rs757406292 19:50919020-50919020 19:50415763-50415763
34 POLD1 NM_001256849.1(POLD1): c.2953+4C> T single nucleotide variant Conflicting interpretations of pathogenicity rs1057521166 19:50919789-50919789 19:50416532-50416532
35 POLD1 NM_001256849.1(POLD1): c.2718-4G> A single nucleotide variant Conflicting interpretations of pathogenicity rs755348897 19:50918977-50918977 19:50415720-50415720
36 POLD1 NM_001256849.1(POLD1): c.2821-5C> T single nucleotide variant Conflicting interpretations of pathogenicity rs1057521374 19:50919648-50919648 19:50416391-50416391
37 POLD1 NM_001256849.1(POLD1): c.2388+4C> T single nucleotide variant Conflicting interpretations of pathogenicity rs371542643 19:50917140-50917140 19:50413883-50413883
38 POLD1 NM_001256849.1(POLD1): c.202+3A> G single nucleotide variant Conflicting interpretations of pathogenicity rs375365167 19:50902313-50902313 19:50399056-50399056
39 POLD1 NM_001256849.1(POLD1): c.639C> T (p.Thr213=) single nucleotide variant Conflicting interpretations of pathogenicity rs139949679 19:50905511-50905511 19:50402254-50402254
40 POLD1 NM_001256849.1(POLD1): c.3067+6C> T single nucleotide variant Conflicting interpretations of pathogenicity rs1057522005 19:50919986-50919986 19:50416729-50416729
41 POLD1 NM_001256849.1(POLD1): c.1594G> A (p.Ala532Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs765276497 19:50910339-50910339 19:50407082-50407082
42 POLD1 NM_001256849.1(POLD1): c.1504G> A (p.Asp502Asn) single nucleotide variant Conflicting interpretations of pathogenicity rs777866589 19:50910249-50910249 19:50406992-50406992
43 POLD1 NM_001256849.1(POLD1): c.2429C> T (p.Ala810Val) single nucleotide variant Conflicting interpretations of pathogenicity rs765981178 19:50918112-50918112 19:50414855-50414855
44 POLD1 NM_001256849.1(POLD1): c.2838G> A (p.Leu946=) single nucleotide variant Conflicting interpretations of pathogenicity rs1060501814 19:50919670-50919670 19:50416413-50416413
45 POLD1 NM_001256849.1(POLD1): c.55C> T (p.Arg19Cys) single nucleotide variant Conflicting interpretations of pathogenicity rs368033860 19:50902163-50902163 19:50398906-50398906
46 POLD1 NM_001256849.1(POLD1): c.841-5C> T single nucleotide variant Conflicting interpretations of pathogenicity rs530091118 19:50905864-50905864 19:50402607-50402607
47 POLD1 NM_001256849.1(POLD1): c.2185G> A (p.Glu729Lys) single nucleotide variant Conflicting interpretations of pathogenicity rs200931999 19:50916713-50916713 19:50413456-50413456
48 POLD1 NM_001256849.1(POLD1): c.2251-4G> A single nucleotide variant Conflicting interpretations of pathogenicity rs768364989 19:50916995-50916995 19:50413738-50413738
49 POLD1 NM_001256849.1(POLD1): c.2250+7G> A single nucleotide variant Conflicting interpretations of pathogenicity rs775363857 19:50916785-50916785 19:50413528-50413528
50 POLD1 NM_001256849.1(POLD1): c.2599G> A (p.Val867Ile) single nucleotide variant Conflicting interpretations of pathogenicity rs367680864 19:50918729-50918729 19:50415472-50415472

UniProtKB/Swiss-Prot genetic disease variations for Colorectal Cancer 10:

74
# Symbol AA change Variation ID SNP ID
1 POLD1 p.Ser478Asn VAR_069335 rs397514632
2 POLD1 p.Leu474Pro VAR_071966 rs587777627

Cosmic variations for Colorectal Cancer 10:

9 (show top 50) (show all 91)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6932 TP53 large intestine,colon,adenoma,NS c.733G>A p.G245S 17:7674230-7674230 3
2 COSM45138 TP53 large intestine,colon,adenoma,NS c.853G>C p.E285Q 17:7673767-7673767 3
3 COSM45076 TP53 large intestine,rectum,adenoma,NS c.432G>C p.Q144H 17:7675180-7675180 3
4 COSM11354 TP53 large intestine,rectum,other,ulcerative colitis c.991C>T p.Q331* 17:7673537-7673537 3
5 COSM43606 TP53 large intestine,rectum,adenoma,NS c.734G>A p.G245D 17:7674229-7674229 3
6 COSM10870 TP53 large intestine,rectum,adenoma,NS c.523C>G p.R175G 17:7675089-7675089 3
7 COSM43687 TP53 large intestine,colon,adenoma,NS c.641A>G p.H214R 17:7674890-7674890 3
8 COSM10648 TP53 large intestine,rectum,adenoma,NS c.524G>A p.R175H 17:7675088-7675088 3
9 COSM10957 TP53 large intestine,colon,adenoma,NS c.733G>C p.G245R 17:7674230-7674230 3
10 COSM43535 TP53 large intestine,colon,adenoma,NS c.391A>C p.N131H 17:7675221-7675221 3
11 COSM10663 TP53 large intestine,colon,adenoma,NS c.916C>T p.R306* 17:7673704-7673704 3
12 COSM21355 STK11 large intestine,rectum,adenoma,NS c.842C>T p.P281L 19:1221320-1221320 3
13 COSM21354 STK11 large intestine,colon,adenoma,NS c.511G>A p.G171S 19:1220419-1220419 3
14 COSM14240 SMAD4 large intestine,colon,adenoma,NS c.988G>C p.E330Q 18:51065455-51065455 3
15 COSM14241 SMAD4 large intestine,colon,adenoma,NS c.1064A>C p.D355A 18:51065531-51065531 3
16 COSM14122 SMAD4 large intestine,rectum,adenoma,NS c.1082G>A p.R361H 18:51065549-51065549 3
17 COSM14143 SMAD4 large intestine,rectum,other,ulcerative colitis c.1546C>T p.Q516* 18:51078354-51078354 3
18 COSM5985099 RB1 large intestine,rectum,adenoma,NS c.1644A>C p.K548N 13:48381392-48381392 3
19 COSM569 NRAS large intestine,colon,adenoma,NS c.37G>C p.G13R 1:114716124-114716124 3
20 COSM584 NRAS large intestine,rectum,adenoma,NS c.182A>G p.Q61R 1:114713908-114713908 3
21 COSM6503131 MSH2 large intestine,colon,adenoma,NS c.589A>G p.K197E 2:47410316-47410316 3
22 COSM520 KRAS large intestine,rectum,adenoma,NS c.35G>T p.G12V 12:25245350-25245350 3
23 COSM521 KRAS large intestine,rectum,adenoma,NS c.35G>A p.G12D 12:25245350-25245350 3
24 COSM532 KRAS large intestine,rectum,adenoma,NS c.38G>A p.G13D 12:25245347-25245347 3
25 COSM553 KRAS large intestine,rectum,adenoma,NS c.182A>T p.Q61L 12:25227342-25227342 3
26 COSM516 KRAS large intestine,colon,adenoma,NS c.34G>T p.G12C 12:25245351-25245351 3
27 COSM528 KRAS large intestine,colon,other,ulcerative colitis c.37G>A p.G13S 12:25245348-25245348 3
28 COSM554 KRAS large intestine,rectum,adenoma,NS c.183A>C p.Q61H 12:25227341-25227341 3
29 COSM517 KRAS large intestine,colon,adenoma,NS c.34G>A p.G12S 12:25245351-25245351 3
30 COSM522 KRAS large intestine,colon,adenoma,NS c.35G>C p.G12A 12:25245350-25245350 3
31 COSM518 KRAS large intestine,colon,adenoma,NS c.34G>C p.G12R 12:25245351-25245351 3
32 COSM555 KRAS large intestine,rectum,adenoma,NS c.183A>T p.Q61H 12:25227341-25227341 3
33 COSM27895 GNAS large intestine,rectum,adenoma,NS c.602G>A p.R201H 20:58909366-58909366 3
34 COSM27887 GNAS large intestine,colon,adenoma,NS c.601C>T p.R201C 20:58909365-58909365 3
35 COSM27058 FBXW7 large intestine,rectum,adenoma,NS c.1436G>T p.R479L 4:152326214-152326214 3
36 COSM22932 FBXW7 large intestine,colon,adenoma,NS c.1393C>T p.R465C 4:152328233-152328233 3
37 COSM22975 FBXW7 large intestine,rectum,adenoma,NS c.1513C>T p.R505C 4:152326137-152326137 3
38 COSM22971 FBXW7 large intestine,colon,adenoma,NS c.832C>T p.R278* 4:152337831-152337831 3
39 COSM30597 FBXW7 large intestine,rectum,adenoma,NS c.892C>T p.P298S 4:152332689-152332689 3
40 COSM22965 FBXW7 large intestine,colon,adenoma,NS c.1394G>A p.R465H 4:152328232-152328232 3
41 COSM25812 FBXW7 large intestine,colon,adenoma,NS c.1514G>A p.R505H 4:152326136-152326136 3
42 COSM30598 FBXW7 large intestine,colon,adenoma,NS c.1558G>A p.D520N 4:152326092-152326092 3
43 COSM21689 EGFR large intestine,colon,adenoma,NS c.1787C>T p.P596L 7:55165344-55165344 3
44 COSM5667 CTNNB1 large intestine,colon,adenoma,NS c.134C>T p.S45F 3:41224646-41224646 3
45 COSM5687 CTNNB1 large intestine,rectum,adenoma,NS c.109T>C p.S37P 3:41224621-41224621 3
46 COSM5671 CTNNB1 large intestine,colon,adenoma,NS c.101G>A p.G34E 3:41224613-41224613 3
47 COSM5664 CTNNB1 large intestine,colon,adenoma,NS c.121A>G p.T41A 3:41224633-41224633 3
48 COSM4675394 CTNNB1 large intestine,colon,adenoma,NS c.490G>A p.D164N 3:41225202-41225202 3
49 COSM5674 CTNNB1 large intestine,colon,adenoma,NS c.104T>G p.I35S 3:41224616-41224616 3
50 COSM5663 CTNNB1 large intestine,colon,adenoma,NS c.133T>C p.S45P 3:41224645-41224645 3
Sources

Expression for Colorectal Cancer 10

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Search GEO for disease gene expression data for Colorectal Cancer 10.
Sources

Pathways for Colorectal Cancer 10

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Sources

GO Terms for Colorectal Cancer 10

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Sources

Sources for Colorectal Cancer 10

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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