CRCS2
MCID: CLR079
MIFTS: 30

Colorectal Cancer 2 (CRCS2)

Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Colorectal Cancer 2

MalaCards integrated aliases for Colorectal Cancer 2:

Name: Colorectal Cancer 2 57 29
Colorectal Cancer, Susceptibility to, 2 57 13
Colorectal Cancer, Susceptibility to, on Chromosome 8q24 57
Colorectal Cancer on Chromosome 8q24 57
Crcs2 57

Classifications:



External Ids:

OMIM® 57 611469

Summaries for Colorectal Cancer 2

MalaCards based summary : Colorectal Cancer 2, also known as colorectal cancer, susceptibility to, 2, is related to muir-torre syndrome and familial colorectal cancer. An important gene associated with Colorectal Cancer 2 is CRCS2 (Colorectal Cancer, Susceptibility To, 2), and among its related pathways/superpathways are Colorectal Cancer Metastasis and Direct p53 effectors. Affiliated tissues include colon, lymph node and appendix.

More information from OMIM: 611469

Related Diseases for Colorectal Cancer 2

Diseases in the Colorectal Cancer family:

Colorectal Cancer 1 Colorectal Cancer 2
Colorectal Cancer 3 Colorectal Cancer 5
Colorectal Cancer 6 Colorectal Cancer 7
Colorectal Cancer 8 Colorectal Cancer 9
Colorectal Cancer 10 Colorectal Cancer 11
Colorectal Cancer 12 Familial Colorectal Cancer
Familial Colorectal Cancer Type X

Diseases related to Colorectal Cancer 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Related Disease Score Top Affiliating Genes
1 muir-torre syndrome 29.5 MSH2 MLH1
2 familial colorectal cancer 29.5 MSH2 MLH1
3 colorectal cancer, hereditary nonpolyposis, type 2 11.4
4 colorectal cancer 10.1
5 tumor predisposition syndrome 9.9
6 cutaneous telangiectasia and cancer syndrome, familial 9.9
7 covid-19 9.9
8 erythrokeratoderma ''en cocardes'' 9.9
9 inherited cancer-predisposing syndrome 9.9
10 rare genetic skin disease 9.9
11 extrahepatic bile duct adenoma 9.8 MSH2 MLH1
12 adenoma 9.8 MSH2 MLH1
13 renal pelvis transitional cell carcinoma 9.8 MSH2 MLH1
14 transitional cell carcinoma 9.8 MSH2 MLH1
15 adenosquamous colon carcinoma 9.8 MSH2 MLH1
16 rectum signet ring adenocarcinoma 9.8 MSH2 MLH1
17 autosomal dominant non-syndromic intellectual disability 8 9.8 MSH2 MLH1
18 appendix carcinoid tumor 9.8 MSH2 MLH1
19 jejunal cancer 9.8 MSH2 MLH1
20 mismatch repair cancer syndrome 9.8 MSH2 MLH1
21 intracranial meningioma 9.8 MSH2 MLH1
22 ascending colon cancer 9.8 MSH2 MLH1
23 lower lip cancer 9.8 MSH2 MLH1
24 colorectal cancer, hereditary nonpolyposis, type 6 9.8 MSH2 MLH1
25 colorectal cancer, hereditary nonpolyposis, type 5 9.8 MSH2 MLH1
26 sebaceous gland neoplasm 9.8 MSH2 MLH1
27 sebaceous adenoma 9.8 MSH2 MLH1
28 small intestine adenocarcinoma 9.8 MSH2 MLH1
29 duodenum adenocarcinoma 9.8 MSH2 MLH1
30 anal fistula 9.8 MSH2 MLH1
31 dysplastic nevus syndrome 9.8 MSH2 MLH1
32 melanocytic nevus syndrome, congenital 9.8 MSH2 MLH1
33 female reproductive endometrioid cancer 9.8 MSH2 MLH1
34 duodenum cancer 9.8 MSH2 MLH1
35 duodenum disease 9.8 MSH2 MLH1
36 breast-ovarian cancer, familial 1 9.8 MSH2 MLH1
37 mismatch repair cancer syndrome 1 9.8 MSH2 MLH1
38 ureter, cancer of 9.8 MSH2 MLH1
39 sebaceous adenocarcinoma 9.8 MSH2 MLH1
40 cecum carcinoma 9.8 MSH2 MLH1
41 hereditary nonpolyposis colon cancer 9.8 MSH2 MLH1
42 signet ring cell adenocarcinoma 9.8 MSH2 MLH1
43 hereditary mixed polyposis syndrome 9.8 MSH2 MLH1
44 rectum adenocarcinoma 9.8 MSH2 MLH1
45 uterine corpus cancer 9.8 MSH2 MLH1
46 colonic benign neoplasm 9.8 MSH2 MLH1
47 keratoacanthoma 9.8 MSH2 MLH1
48 small intestine cancer 9.8 MSH2 MLH1
49 lynch syndrome i 9.8 MSH2 MLH1
50 lynch syndrome 9.8 MSH2 MLH1

Graphical network of the top 20 diseases related to Colorectal Cancer 2:



Diseases related to Colorectal Cancer 2

Symptoms & Phenotypes for Colorectal Cancer 2

Clinical features from OMIM®:

611469 (Updated 20-May-2021)

Drugs & Therapeutics for Colorectal Cancer 2

Search Clinical Trials , NIH Clinical Center for Colorectal Cancer 2

Genetic Tests for Colorectal Cancer 2

Genetic tests related to Colorectal Cancer 2:

# Genetic test Affiliating Genes
1 Colorectal Cancer 2 29

Anatomical Context for Colorectal Cancer 2

MalaCards organs/tissues related to Colorectal Cancer 2:

40
Colon, Lymph Node, Appendix, Skin, Breast, Prostate

Publications for Colorectal Cancer 2

Articles related to Colorectal Cancer 2:

(show top 50) (show all 88)
# Title Authors PMID Year
1
Long-range enhancers on 8q24 regulate c-Myc. 57
20133699 2010
2
The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling. 57
19561604 2009
3
The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. 57
19561607 2009
4
Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers. 57
18704501 2008
5
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. 57
18372905 2008
6
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. 57
18372901 2008
7
A common genetic risk factor for colorectal and prostate cancer. 57
17618282 2007
8
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. 57
17618283 2007
9
A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. 57
17618284 2007
10
Penile secondary lesions: a rare entity detected by PET/CT. 61
33723317 2021
11
Developing a prioritization model for endoscopy and colorectal cancer 2-week wait referrals during the COVID-19 pandemic-is faecal immunochemical testing the answer? 61
33640923 2021
12
Long-Term Prevalence of Sensory Chemotherapy-Induced Peripheral Neuropathy for 5 Years after Adjuvant FOLFOX Chemotherapy to Treat Colorectal Cancer: A Multicenter Cross-Sectional Study. 61
32727095 2020
13
Hyperthermic intraperitoneal chemotherapy does not improve survival in advanced ovarian cancer. 61
31967685 2019
14
[Short-term outcomes and prognosis of palliative surgery for malignant bowel obstruction caused by peritoneal metastasis of colorectal cancer]. 61
31770836 2019
15
Dietary interventions for adult cancer survivors. 61
31755089 2019
16
["Watch and wait" strategy after neoadjuvant therapy for rectal cancer: status survey of perceptions, attitudes and treatment selection in Chinese surgeons]. 61
31238634 2019
17
Service evaluation of faecal immunochemical testing and anaemia for risk stratification in the 2-week-wait pathway for colorectal cancer. 61
31183456 2019
18
A study of morphological prognostic factors in colorectal cancer and survival analysis. 61
30706857 2019
19
Malignancy in Systemic Lupus Erythematosus (SLE) Patients 61
30583682 2018
20
[Preliminary report on prospective, multicenter, open research of selective surgery after expandable stent combined with neoadjuvant chemotherapy in the treatment of obstructive left hemicolon cancer]. 61
30506533 2018
21
Serrated epithelial colorectal polyps (hyperplastic polyps, sessile serrated adenomas) with perineurial stroma: Clinicopathological and molecular analysis of a new series. 61
29747061 2018
22
The Role of Cyclooxygenase-2 in Colorectal Carcinogenesis. 61
27810226 2017
23
Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells. 61
28659575 2017
24
A systematic review of prehabilitation programs in abdominal cancer surgery. 61
28161527 2017
25
Stromal COX-2 signaling are correlated with colorectal cancer: A review. 61
27823649 2016
26
Cytoreductive surgery and intraperitoneal chemotherapy for peritoneal carcinomatosis of colorectal cancer: 2-year follow-up results at a single institution in Korea. 61
27757392 2016
27
appendix 5: Metastatic colorectal cancer (2): eUpdate published online August 2016 (www.esmo.org/Guidelines/Gastrointestinal-Cancers). 61
27664253 2016
28
Early Outcomes of Endoscopic Submucosal Dissection for Colorectal Neoplasms According to Clinical Indications. 61
27050602 2016
29
Determining the familial risk distribution of colorectal cancer: a data mining approach. 61
26681340 2016
30
Observational cohort study focused on treatment continuity of patients administered XELOX plus bevacizumab for previously untreated metastatic colorectal cancer. 61
27468238 2016
31
Plasma TIMP-1 and CEA as Markers for Detection of Primary Colorectal Cancer: A Prospective Validation Study Including Symptomatic and Non-symptomatic Individuals. 61
26254391 2015
32
Metals distribution in colorectal biopsies: New insight on the elemental fingerprint of tumour tissue. 61
25869551 2015
33
[Single-port laparoscopic stoma creation for fecal diversion - experience of ten consecutive patients]. 61
25731281 2014
34
Processed pseudogenes acquired somatically during cancer development. 61
24714652 2014
35
Usefulness of acoustic radiation force impulse elastography in the differential diagnosis of benign and malignant solid pancreatic lesions. 61
24936492 2014
36
Screening for Muir-Torre syndrome using mismatch repair protein immunohistochemistry of sebaceous neoplasms. 61
23212176 2013
37
Intestinal and extraintestinal neoplasia in patients with inflammatory bowel disease in a tertiary care hospital. 61
23903622 2013
38
Intraoperative high-dose-rate brachytherapy using dose painting technique: evaluation of safety and preliminary clinical outcomes. 61
23167979 2013
39
Determinants of increased primary health care use in cancer survivors. 61
23071230 2012
40
Evaluation of histological regression grading systems in the neoadjuvant therapy of rectal cancer: do they have prognostic impact? 61
22614681 2012
41
Patient-reported long-term rectal function after permanent interstitial brachytherapy for clinically localized prostate cancer. 61
22561216 2012
42
The C/A polymorphism in intron 11 of the XPC gene plays a crucial role in the modulation of an individual's susceptibility to sporadic colorectal cancer. 61
21559836 2012
43
A patient presenting nasal septum perforation during bevacizumab-containing chemotherapy for advanced breast cancer. 61
21312011 2011
44
Endoscopic submucosal dissection for premalignant lesions and noninvasive early gastrointestinal cancers. 61
21483630 2011
45
CHEK2 mutations and HNPCC-related colorectal cancer. 61
19876921 2010
46
Colorectal cancer: 2 steps backward. 61
19820071 2009
47
Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival in selected patients with peritoneal carcinomatosis from abdominal and pelvic malignancies: results of 21 cases. 61
19018599 2009
48
Genetic testing offered directly after the diagnosis of colorectal cancer: a pilot study on the reactions of patients. 61
20162866 2009
49
Inflammatory bowel disease: a model of chronic inflammation-induced cancer. 61
19347299 2009
50
Involvement of surgical trainees in surgery for colorectal cancer and their effect on outcome. 61
18318753 2008

Variations for Colorectal Cancer 2

Expression for Colorectal Cancer 2

Search GEO for disease gene expression data for Colorectal Cancer 2.

Pathways for Colorectal Cancer 2

GO Terms for Colorectal Cancer 2

Cellular components related to Colorectal Cancer 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 8.62 MSH2 MLH1

Biological processes related to Colorectal Cancer 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.43 MSH2 MLH1
2 mismatch repair GO:0006298 9.4 MSH2 MLH1
3 isotype switching GO:0045190 9.37 MSH2 MLH1
4 somatic hypermutation of immunoglobulin genes GO:0016446 9.32 MSH2 MLH1
5 positive regulation of isotype switching to IgG isotypes GO:0048304 9.26 MSH2 MLH1
6 positive regulation of isotype switching to IgA isotypes GO:0048298 9.16 MSH2 MLH1
7 somatic recombination of immunoglobulin gene segments GO:0016447 8.96 MSH2 MLH1
8 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 8.62 MSH2 MLH1

Molecular functions related to Colorectal Cancer 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.26 MSH2 MLH1
2 single-stranded DNA binding GO:0003697 9.16 MSH2 MLH1
3 mismatched DNA binding GO:0030983 8.96 MSH2 MLH1
4 guanine/thymine mispair binding GO:0032137 8.62 MSH2 MLH1

Sources for Colorectal Cancer 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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