CRCS2
MCID: CLR079
MIFTS: 20

Colorectal Cancer 2 (CRCS2)

Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Colorectal Cancer 2

MalaCards integrated aliases for Colorectal Cancer 2:

Name: Colorectal Cancer 2 58 30
Colorectal Cancer, Susceptibility to, 2 58 13
Colorectal Cancer, Susceptibility to, on Chromosome 8q24 58
Colorectal Cancer on Chromosome 8q24 58
Crcs2 58

Classifications:



External Ids:

OMIM 58 611469

Summaries for Colorectal Cancer 2

MalaCards based summary : Colorectal Cancer 2, also known as colorectal cancer, susceptibility to, 2, is related to colorectal cancer, hereditary nonpolyposis, type 2 and colorectal cancer. An important gene associated with Colorectal Cancer 2 is CRCS2 (Colorectal Cancer, Susceptibility To, 2). Affiliated tissues include appendix, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Description from OMIM: 611469

Related Diseases for Colorectal Cancer 2

Diseases in the Colorectal Cancer family:

Colorectal Cancer 1 Colorectal Cancer 2
Colorectal Cancer 3 Colorectal Cancer 5
Colorectal Cancer 6 Colorectal Cancer 7
Colorectal Cancer 8 Colorectal Cancer 9
Colorectal Cancer 10 Colorectal Cancer 11
Colorectal Cancer 12 Familial Colorectal Cancer
Familial Colorectal Cancer Type X

Diseases related to Colorectal Cancer 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 colorectal cancer, hereditary nonpolyposis, type 2 11.8
2 colorectal cancer 10.0

Symptoms & Phenotypes for Colorectal Cancer 2

Clinical features from OMIM:

611469

GenomeRNAi Phenotypes related to Colorectal Cancer 2 according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.61 MLH1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.61 MLH1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.61 TK1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.61 MLH1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.61 TK1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.61 TK1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.61 MLH1 TK1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.61 TK1
9 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.62 MLH1 TK1

Drugs & Therapeutics for Colorectal Cancer 2

Search Clinical Trials , NIH Clinical Center for Colorectal Cancer 2

Genetic Tests for Colorectal Cancer 2

Genetic tests related to Colorectal Cancer 2:

# Genetic test Affiliating Genes
1 Colorectal Cancer 2 30

Anatomical Context for Colorectal Cancer 2

MalaCards organs/tissues related to Colorectal Cancer 2:

42
Appendix

Publications for Colorectal Cancer 2

Articles related to Colorectal Cancer 2:

# Title Authors Year
1
appendix 5: Metastatic colorectal cancer (2): eUpdate published online August 2016 (www.esmo.org/Guidelines/Gastrointestinal-Cancers). ( 27664253 )
2016
2
Cytoreductive surgery and intraperitoneal chemotherapy for peritoneal carcinomatosis of colorectal cancer: 2-year follow-up results at a single institution in Korea. ( 27757392 )
2016
3
Colorectal cancer: 2 steps backward. ( 19820071 )
2009
4
A control trial of faecal occult blood screening for colorectal cancer: 2-year results. ( 3899267 )
1985

Variations for Colorectal Cancer 2

Expression for Colorectal Cancer 2

Search GEO for disease gene expression data for Colorectal Cancer 2.

Pathways for Colorectal Cancer 2

GO Terms for Colorectal Cancer 2

Sources for Colorectal Cancer 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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