CRCS5
MCID: CLR080
MIFTS: 26

Colorectal Cancer 5 (CRCS5)

Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Colorectal Cancer 5

MalaCards integrated aliases for Colorectal Cancer 5:

Name: Colorectal Cancer 5 58 30
Colorectal Cancer, Susceptibility to, 5 58 13
Colorectal Cancer, Susceptibility to, on Chromosome 10 58
Colorectal Cancer on Chromosome 10 58
Crcs5 58

Classifications:



External Ids:

OMIM 58 612230

Summaries for Colorectal Cancer 5

MalaCards based summary : Colorectal Cancer 5, also known as colorectal cancer, susceptibility to, 5, is related to colorectal cancer, hereditary nonpolyposis, type 5 and colorectal cancer. An important gene associated with Colorectal Cancer 5 is CRCS5 (Colorectal Cancer, Susceptibility To, 5), and among its related pathways/superpathways is DNA Damage. The drugs Paclitaxel and Capecitabine have been mentioned in the context of this disorder. Affiliated tissues include breast.

Description from OMIM: 612230

Related Diseases for Colorectal Cancer 5

Symptoms & Phenotypes for Colorectal Cancer 5

Clinical features from OMIM:

612230

Drugs & Therapeutics for Colorectal Cancer 5

Drugs for Colorectal Cancer 5 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
2
Capecitabine Approved, Investigational Phase 1 154361-50-9 60953
3 Antimetabolites Phase 1
4 Antimetabolites, Antineoplastic Phase 1
5 Albumin-Bound Paclitaxel Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pazopanib in Combination With Capecitabine in Patients With Metastatic Breast Cancer Completed NCT01498458 Phase 1 Pazopanib plus capecitabine

Search NIH Clinical Center for Colorectal Cancer 5

Genetic Tests for Colorectal Cancer 5

Genetic tests related to Colorectal Cancer 5:

# Genetic test Affiliating Genes
1 Colorectal Cancer 5 30

Anatomical Context for Colorectal Cancer 5

MalaCards organs/tissues related to Colorectal Cancer 5:

42
Breast

Publications for Colorectal Cancer 5

Articles related to Colorectal Cancer 5:

# Title Authors Year
1
Platelet Count, ADAMTS13 Activity, von Willebrand Factor Level and Survival in Patients with Colorectal Cancer: 5-Year Follow-up Study. ( 29304532 )
2018
2
Colorectal cancer: 5 big questions. ( 25970454 )
2015
3
SNAI2 Modulates Colorectal Cancer 5-Fluorouracil Sensitivity through miR145 Repression. ( 25249558 )
2014
4
The mesenteric and antimesenteric site of the tumor as possible prognostic factor in colorectal cancer: 5-year survival analysis. ( 18032025 )
2007
5
Efficacy of oral adjuvant therapy after resection of colorectal cancer: 5-year results from three randomized trials. ( 14752071 )
2004

Variations for Colorectal Cancer 5

Expression for Colorectal Cancer 5

Search GEO for disease gene expression data for Colorectal Cancer 5.

Pathways for Colorectal Cancer 5

Pathways related to Colorectal Cancer 5 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.09 DPYD MSH6

GO Terms for Colorectal Cancer 5

Biological processes related to Colorectal Cancer 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyrimidine nucleoside catabolic process GO:0046135 8.62 DPYD TYMP

Molecular functions related to Colorectal Cancer 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 8.8 DPYD MSH6 TYMP

Sources for Colorectal Cancer 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....