CRCS5
MCID: CLR080
MIFTS: 35

Colorectal Cancer 5 (CRCS5)

Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Colorectal Cancer 5

MalaCards integrated aliases for Colorectal Cancer 5:

Name: Colorectal Cancer 5 57 29
Colorectal Cancer, Susceptibility to, 5 57 13
Colorectal Cancer, Susceptibility to, on Chromosome 10 57
Colorectal Cancer on Chromosome 10 57
Crcs5 57

Classifications:



External Ids:

OMIM 57 612230

Summaries for Colorectal Cancer 5

MalaCards based summary : Colorectal Cancer 5, also known as colorectal cancer, susceptibility to, 5, is related to colorectal cancer, hereditary nonpolyposis, type 5 and colorectal cancer. An important gene associated with Colorectal Cancer 5 is CRCS5 (Colorectal Cancer, Susceptibility To, 5), and among its related pathways/superpathways are DNA Damage and Colorectal Cancer Metastasis. Affiliated tissues include liver, skin and colon.

Description from OMIM: 612230

Related Diseases for Colorectal Cancer 5

Diseases in the Colorectal Cancer family:

Colorectal Cancer 1 Colorectal Cancer 2
Colorectal Cancer 3 Colorectal Cancer 5
Colorectal Cancer 6 Colorectal Cancer 7
Colorectal Cancer 8 Colorectal Cancer 9
Colorectal Cancer 10 Colorectal Cancer 11
Colorectal Cancer 12 Familial Colorectal Cancer
Familial Colorectal Cancer Type X

Diseases related to Colorectal Cancer 5 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 colorectal cancer, hereditary nonpolyposis, type 5 32.7 MLH1 MSH6
2 colorectal cancer 29.0 CRCS5 DPYD MLH1 MSH6 UMPS
3 appendix carcinoid tumor 10.0 MLH1 MSH6
4 adenosquamous colon carcinoma 10.0 MLH1 MSH6
5 sebaceous adenoma 10.0 MLH1 MSH6
6 gastric leiomyoma 10.0 MLH1 MSH6
7 cecum adenocarcinoma 10.0 MLH1 MSH6
8 lynch syndrome 10.0 MLH1 MSH6
9 lynch syndrome i 10.0 MLH1 MSH6
10 sebaceous adenocarcinoma 10.0 MLH1 MSH6
11 muir-torre syndrome 10.0 MLH1 MSH6
12 skin benign neoplasm 10.0 MLH1 MSH6
13 small intestine cancer 10.0 MLH1 MSH6
14 mismatch repair cancer syndrome 10.0 MLH1 MSH6
15 uterine anomalies 10.0 MLH1 MSH6
16 colonic disease 10.0 MLH1 MSH6
17 colorectal adenocarcinoma 10.0 MLH1 MSH6
18 hereditary breast ovarian cancer syndrome 10.0 MLH1 MSH6
19 female reproductive system disease 10.0 MLH1 MSH6
20 autosomal genetic disease 10.0 MLH1 MSH6
21 intestinal disease 9.9 MLH1 MSH6
22 rectal neoplasm 9.9 DPYD MLH1
23 pyrimidine metabolic disorder 9.9 DPYD UMPS
24 gastrointestinal system cancer 9.9 MLH1 MSH6
25 dihydropyrimidine dehydrogenase deficiency 9.9 DPYD UMPS
26 orotic aciduria 9.9 DPYD UMPS
27 autosomal dominant disease 9.9 MLH1 MSH6
28 familial adenomatous polyposis 9.9 MLH1 MSH6
29 colon adenocarcinoma 9.9 MLH1 MSH6
30 large intestine cancer 9.8 DPYD MLH1 MSH6
31 gastric cancer 9.4 DPYD MLH1 UMPS

Graphical network of the top 20 diseases related to Colorectal Cancer 5:



Diseases related to Colorectal Cancer 5

Symptoms & Phenotypes for Colorectal Cancer 5

Clinical features from OMIM:

612230

Drugs & Therapeutics for Colorectal Cancer 5

Search Clinical Trials , NIH Clinical Center for Colorectal Cancer 5

Genetic Tests for Colorectal Cancer 5

Genetic tests related to Colorectal Cancer 5:

# Genetic test Affiliating Genes
1 Colorectal Cancer 5 29

Anatomical Context for Colorectal Cancer 5

MalaCards organs/tissues related to Colorectal Cancer 5:

41
Liver, Skin, Colon, Breast, Small Intestine, Appendix

Publications for Colorectal Cancer 5

Articles related to Colorectal Cancer 5:

# Title Authors Year
1
Platelet Count, ADAMTS13 Activity, von Willebrand Factor Level and Survival in Patients with Colorectal Cancer: 5-Year Follow-up Study. ( 29304532 )
2018
2
Colorectal cancer: 5 big questions. ( 25970454 )
2015
3
SNAI2 modulates colorectal cancer 5-fluorouracil sensitivity through miR145 repression. ( 25249558 )
2014
4
The mesenteric and antimesenteric site of the tumor as possible prognostic factor in colorectal cancer: 5-year survival analysis. ( 18032025 )
2007
5
Efficacy of oral adjuvant therapy after resection of colorectal cancer: 5-year results from three randomized trials. ( 14752071 )
2004

Variations for Colorectal Cancer 5

Expression for Colorectal Cancer 5

Search GEO for disease gene expression data for Colorectal Cancer 5.

Pathways for Colorectal Cancer 5

GO Terms for Colorectal Cancer 5

Cellular components related to Colorectal Cancer 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 8.62 MLH1 MSH6

Biological processes related to Colorectal Cancer 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.32 MLH1 MSH6
2 mismatch repair GO:0006298 9.26 MLH1 MSH6
3 somatic hypermutation of immunoglobulin genes GO:0016446 9.16 MLH1 MSH6
4 isotype switching GO:0045190 8.96 MLH1 MSH6
5 somatic recombination of immunoglobulin gene segments GO:0016447 8.62 MLH1 MSH6

Molecular functions related to Colorectal Cancer 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 8.96 MLH1 MSH6
2 guanine/thymine mispair binding GO:0032137 8.62 MLH1 MSH6

Sources for Colorectal Cancer 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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