MCID: CLR080
MIFTS: 27

Colorectal Cancer 5

Categories: Cancer diseases, Genetic diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Colorectal Cancer 5

MalaCards integrated aliases for Colorectal Cancer 5:

Name: Colorectal Cancer 5 57 29
Colorectal Cancer, Susceptibility to, 5 57 13
Colorectal Cancer, Susceptibility to, on Chromosome 10 57
Colorectal Cancer on Chromosome 10 57
Crcs5 57

Classifications:



External Ids:

OMIM 57 612230

Summaries for Colorectal Cancer 5

MalaCards based summary : Colorectal Cancer 5, also known as colorectal cancer, susceptibility to, 5, is related to colorectal cancer and colorectal cancer, hereditary nonpolyposis, type 5. An important gene associated with Colorectal Cancer 5 is CRCS5 (Colorectal Cancer, Susceptibility To, 5), and among its related pathways/superpathways are TGF-beta Signaling Pathways and BRCA1 Pathway. The drugs Capecitabine and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include breast.

Description from OMIM: 612230

Related Diseases for Colorectal Cancer 5

Symptoms & Phenotypes for Colorectal Cancer 5

Clinical features from OMIM:

612230

Drugs & Therapeutics for Colorectal Cancer 5

Drugs for Colorectal Cancer 5 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 1 154361-50-9 60953
2
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
3 Albumin-Bound Paclitaxel Phase 1
4 Antimetabolites Phase 1
5 Antimetabolites, Antineoplastic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pazopanib in Combination With Capecitabine in Patients With Metastatic Breast Cancer Completed NCT01498458 Phase 1 Pazopanib plus capecitabine

Search NIH Clinical Center for Colorectal Cancer 5

Genetic Tests for Colorectal Cancer 5

Genetic tests related to Colorectal Cancer 5:

# Genetic test Affiliating Genes
1 Colorectal Cancer 5 29

Anatomical Context for Colorectal Cancer 5

MalaCards organs/tissues related to Colorectal Cancer 5:

41
Breast

Publications for Colorectal Cancer 5

Articles related to Colorectal Cancer 5:

# Title Authors Year
1
Colorectal cancer: 5 big questions. ( 25970454 )
2015

Variations for Colorectal Cancer 5

Expression for Colorectal Cancer 5

Search GEO for disease gene expression data for Colorectal Cancer 5.

Pathways for Colorectal Cancer 5

Pathways related to Colorectal Cancer 5 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.35 ATF1 SMAD3
2
Show member pathways
11.24 ATF1 MSH6
3 11.21 ATF1 AXIN1 SMAD3
4 10.96 AXIN1 SMAD3
5 10.63 AXIN1 SMAD3
6 10.46 ATF1 MSH6 SMAD3

GO Terms for Colorectal Cancer 5

Biological processes related to Colorectal Cancer 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 canonical Wnt signaling pathway GO:0060070 9.16 AXIN1 SMAD3
2 negative regulation of fat cell differentiation GO:0045599 8.96 AXIN1 SMAD3
3 cellular protein-containing complex assembly GO:0034622 8.62 ATF1 AXIN1

Molecular functions related to Colorectal Cancer 5 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 beta-catenin binding GO:0008013 8.96 AXIN1 SMAD3
2 SMAD binding GO:0046332 8.62 AXIN1 SMAD3

Sources for Colorectal Cancer 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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