CRCS6
MCID: CLR081
MIFTS: 21

Colorectal Cancer 6 (CRCS6)

Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Colorectal Cancer 6

MalaCards integrated aliases for Colorectal Cancer 6:

Name: Colorectal Cancer 6 58
Colorectal Cancer, Susceptibility to, 6 58 13
Colorectal Cancer, Susceptibility to, on Chromosome 8q23 58
Colorectal Cancer on Chromosome 8q23 58
Crcs6 58

Classifications:



External Ids:

OMIM 58 612231

Summaries for Colorectal Cancer 6

MalaCards based summary : Colorectal Cancer 6, also known as colorectal cancer, susceptibility to, 6, is related to colorectal cancer, hereditary nonpolyposis, type 6 and colorectal cancer. An important gene associated with Colorectal Cancer 6 is CRCS6 (Colorectal Cancer, Susceptibility To, 6), and among its related pathways/superpathways are Regulation of lipid metabolism Insulin signaling-generic cascades and mTOR Pathway. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Description from OMIM: 612231

Related Diseases for Colorectal Cancer 6

Symptoms & Phenotypes for Colorectal Cancer 6

Clinical features from OMIM:

612231

GenomeRNAi Phenotypes related to Colorectal Cancer 6 according to GeneCards Suite gene sharing:

27 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.85 TGFBR2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.85 TGFBR2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.85 TGFBR2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.85 TGFBR2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.85 TGFBR2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.85 PRKAA1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.85 TGFBR2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.85 PRKAA1 TGFBR2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.85 TGFBR2
10 Decreased viability GR00107-A-1 9.65 TGFBR2
11 Decreased viability GR00221-A-1 9.65 PRKAA1 TGFBR2
12 Decreased viability GR00221-A-2 9.65 PRKAA1
13 Decreased viability GR00221-A-3 9.65 TGFBR2
14 Decreased viability GR00221-A-4 9.65 TGFBR2
15 Decreased viability GR00342-S-2 9.65 PRKAA1
16 Decreased viability GR00342-S-3 9.65 PRKAA1
17 Decreased viability GR00402-S-2 9.65 PRKAA1 TGFBR2
18 Increased cell viability after pRB stimulation GR00230-A-1 8.62 PRKAA1 TGFBR2

Drugs & Therapeutics for Colorectal Cancer 6

Search Clinical Trials , NIH Clinical Center for Colorectal Cancer 6

Genetic Tests for Colorectal Cancer 6

Anatomical Context for Colorectal Cancer 6

Publications for Colorectal Cancer 6

Variations for Colorectal Cancer 6

Expression for Colorectal Cancer 6

Search GEO for disease gene expression data for Colorectal Cancer 6.

Pathways for Colorectal Cancer 6

GO Terms for Colorectal Cancer 6

Biological processes related to Colorectal Cancer 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 8.96 PRKAA1 TGFBR2
2 response to hypoxia GO:0001666 8.62 PRKAA1 TGFBR2

Molecular functions related to Colorectal Cancer 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 8.96 PRKAA1 TGFBR2
2 protein serine/threonine kinase activity GO:0004674 8.62 PRKAA1 TGFBR2

Sources for Colorectal Cancer 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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