CRCS6
MCID: CLR081
MIFTS: 24

Colorectal Cancer 6 (CRCS6)

Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Colorectal Cancer 6

MalaCards integrated aliases for Colorectal Cancer 6:

Name: Colorectal Cancer 6 56 29
Colorectal Cancer, Susceptibility to, 6 56 13
Colorectal Cancer, Susceptibility to, on Chromosome 8q23 56
Colorectal Cancer on Chromosome 8q23 56
Crcs6 56

Classifications:



External Ids:

OMIM 56 612231

Summaries for Colorectal Cancer 6

MalaCards based summary : Colorectal Cancer 6, also known as colorectal cancer, susceptibility to, 6, is related to colorectal cancer, hereditary nonpolyposis, type 6 and colorectal cancer. An important gene associated with Colorectal Cancer 6 is CRCS6 (Colorectal Cancer, Susceptibility To, 6). The drugs Capecitabine and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include prostate, brain and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

More information from OMIM: 612231

Related Diseases for Colorectal Cancer 6

Diseases in the Colorectal Cancer family:

Colorectal Cancer 1 Colorectal Cancer 2
Colorectal Cancer 3 Colorectal Cancer 5
Colorectal Cancer 6 Colorectal Cancer 7
Colorectal Cancer 8 Colorectal Cancer 9
Colorectal Cancer 10 Colorectal Cancer 11
Colorectal Cancer 12 Familial Colorectal Cancer
Familial Colorectal Cancer Type X

Diseases related to Colorectal Cancer 6 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 colorectal cancer, hereditary nonpolyposis, type 6 12.0
2 colorectal cancer 11.5

Symptoms & Phenotypes for Colorectal Cancer 6

Clinical features from OMIM:

612231

GenomeRNAi Phenotypes related to Colorectal Cancer 6 according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.88 TGFBR2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-117 9.88 PFKFB3
3 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.88 TGFBR2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.88 TGFBR2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.88 PFKFB3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.88 TGFBR2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-148 9.88 PFKFB3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.88 PFKFB3
9 Increased shRNA abundance (Z-score > 2) GR00366-A-162 9.88 TGFBR2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-165 9.88 TGFBR2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.88 TGFBR2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.88 TGFBR2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.88 TGFBR2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.88 PFKFB3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-48 9.88 TGFBR2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.88 TGFBR2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.88 TGFBR2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.88 PFKFB3

Drugs & Therapeutics for Colorectal Cancer 6

Drugs for Colorectal Cancer 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 43805 6857599 5310940 9887054
4 Angiogenesis Inhibitors Phase 2
5 Antimetabolites Phase 2
6 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Non Randomized Phase II Trial to Assess Efficacy and Safety of Bevacizumab, Capecitabine and Oxaliplatin as First Line Treatment for Elderly Patients With Metastatic Colorectal Adenocarcinoma, Suitable for Polychemotherapy Treatment Unknown status NCT01067053 Phase 2 bevacizumab, capecitabine, oxaliplatin
2 A Phase II Trial of MB-6 Plus FOLFOX4 for Metastatic Colorectal Cancer Completed NCT01047475 Phase 2 MB-6;Placebo
3 To Identify Potential New Urine Markers for the Screening of Prostate Cancer Recruiting NCT03914391

Search NIH Clinical Center for Colorectal Cancer 6

Genetic Tests for Colorectal Cancer 6

Genetic tests related to Colorectal Cancer 6:

# Genetic test Affiliating Genes
1 Colorectal Cancer 6 29

Anatomical Context for Colorectal Cancer 6

MalaCards organs/tissues related to Colorectal Cancer 6:

40
Prostate, Brain, Liver, Lung

Publications for Colorectal Cancer 6

Articles related to Colorectal Cancer 6:

(show all 25)
# Title Authors PMID Year
1
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. 56
18372905 2008
2
[Priority setting in scaled-up cancer screening in China: an systematic review of economic evaluation evidences]. 61
32187937 2020
3
[Analysis of the characteristics of second primary malignancy affecting the survival of lymphoma patients]. 61
32135650 2020
4
Management of malabsorptive bariatric surgery after cancer surgery for malignancies of the digestive apparatus. 61
29705564 2018
5
Prognostic value of increased integrin-beta 1 expression in solid cancers: a meta-analysis. 61
29636624 2018
6
Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Women: Evidence Report and Systematic Review for the US Preventive Services Task Force. 61
29234813 2017
7
Randomized controlled trials evaluating cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in prevention and therapy of peritoneal metastasis: a systematic review. 61
30911621 2016
8
Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on Colorectal Cancer. 61
25003300 2014
9
FBXW7 mutations in patients with advanced cancers: clinical and molecular characteristics and outcomes with mTOR inhibitors. 61
24586741 2014
10
Clinically relevant changes in family history of cancer over time. 61
21750294 2011
11
Surveillance with serial serum carcinoembryonic levels detect colorectal cancer recurrences in patients who are initial nonsecretors. 61
21105619 2010
12
Right hepatic lobectomy using the staple technique in 101 patients. 61
17701266 2008
13
Clinicopathological features of nonpolypoid colorectal tumors as viewed from the patients' background. 61
16741611 2006
14
Neoplastic meningitis-related encephalopathy. 61
15926000 2005
15
[Therapy of malignant liver tumors using microwave and radiofrequency ablation]. 61
15957451 2005
16
PET with O-(2-18F-Fluoroethyl)-L-Tyrosine in peripheral tumors: first clinical results. 61
15750152 2005
17
Pilot trial evaluating an 123I-labeled 80-kilodalton engineered anticarcinoembryonic antigen antibody fragment (cT84.66 minibody) in patients with colorectal cancer. 61
15297402 2004
18
Radiotherapy wait times for patients with a diagnosis of invasive cancer, 1992-2000. 61
15305806 2004
19
Symptomatic venous thromboembolism in cancer patients treated with chemotherapy: an underestimated phenomenon. 61
14744843 2004
20
Phase I and pharmacokinetic study of irinotecan in combination with raltitrexed. 61
12357298 2002
21
[Surgery for metastatic brain and spinal tumor from colorectal cancer]. 61
10560404 1999
22
[Effect of acupoint irradiation with Q-wave millimeter microwave on peripheral white blood cells in post-operational treatment with chemotherapy in stomach and colorectal cancer patients]. 61
9863113 1997
23
Primary and recurrent colorectal cancer masquerading as gynaecological malignancy. 61
8798306 1996
24
Gallstones, cholecystectomy, and colorectal cancer. 61
8249962 1993
25
[Chemotherapy for metastatic lung cancer]. 61
6876421 1983

Variations for Colorectal Cancer 6

Expression for Colorectal Cancer 6

Search GEO for disease gene expression data for Colorectal Cancer 6.

Pathways for Colorectal Cancer 6

GO Terms for Colorectal Cancer 6

Biological processes related to Colorectal Cancer 6 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 brain development GO:0007420 8.96 TGFBR2 PFKFB3
2 positive regulation of angiogenesis GO:0045766 8.62 TGFBR2 MIR27B

Sources for Colorectal Cancer 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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