CRCS7
MCID: CLR082
MIFTS: 22

Colorectal Cancer 7 (CRCS7)

Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Colorectal Cancer 7

MalaCards integrated aliases for Colorectal Cancer 7:

Name: Colorectal Cancer 7 57
Colorectal Cancer, Susceptibility to, 7 57 13
Colorectal Cancer, Susceptibility to, on Chromosome 11 57
Colorectal Cancer on Chromosome 11 57
Crcs7 57

Classifications:



External Ids:

OMIM 57 612232

Summaries for Colorectal Cancer 7

MalaCards based summary : Colorectal Cancer 7, also known as colorectal cancer, susceptibility to, 7, is related to colorectal cancer, hereditary nonpolyposis, type 7 and colorectal cancer. An important gene associated with Colorectal Cancer 7 is CRCS7 (Colorectal Cancer, Susceptibility To, 7). The drugs leucovorin and Folic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, colon and liver.

More information from OMIM: 612232

Related Diseases for Colorectal Cancer 7

Diseases in the Colorectal Cancer family:

Colorectal Cancer 1 Colorectal Cancer 2
Colorectal Cancer 3 Colorectal Cancer 5
Colorectal Cancer 6 Colorectal Cancer 7
Colorectal Cancer 8 Colorectal Cancer 9
Colorectal Cancer 10 Colorectal Cancer 11
Colorectal Cancer 12 Familial Colorectal Cancer
Familial Colorectal Cancer Type X

Diseases related to Colorectal Cancer 7 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 colorectal cancer, hereditary nonpolyposis, type 7 12.0
2 colorectal cancer 11.4

Symptoms & Phenotypes for Colorectal Cancer 7

Clinical features from OMIM:

612232

Drugs & Therapeutics for Colorectal Cancer 7

Drugs for Colorectal Cancer 7 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 2, Phase 3 58-05-9 143 6006
2
Folic acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
3
Vitamin C Approved, Nutraceutical Phase 2, Phase 3 50-81-7 54670067 5785
4
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3 65-23-6 1054
5 Micronutrients Phase 2, Phase 3
6 Trace Elements Phase 2, Phase 3
7 Antioxidants Phase 2, Phase 3
8 Vitamins Phase 2, Phase 3
9 Vitamin B Complex Phase 2, Phase 3
10 Hematinics Phase 2, Phase 3
11 Vitamin B9 Phase 2, Phase 3
12 Folate Phase 2, Phase 3
13 Vitamin B 6 Phase 2, Phase 3
14 Protective Agents Phase 2, Phase 3
15 Nutrients Phase 2, Phase 3
16
Pyridoxal Experimental, Nutraceutical Phase 2, Phase 3 66-72-8 1050
17
Bevacizumab Approved, Investigational Phase 1 216974-75-3
18
Sirolimus Approved, Investigational Phase 1 53123-88-9 6436030 5284616 46835353
19
Panitumumab Approved, Investigational Phase 1 339177-26-3 50070211
20
Everolimus Approved Phase 1 159351-69-6 6442177 70789204
21
Miconazole Approved, Investigational, Vet_approved Phase 1 22916-47-8 4189
22 Intetumumab Investigational Phase 1 725735-28-4
23 Immunologic Factors Phase 1
24 Angiogenesis Inhibitors Phase 1
25 Antineoplastic Agents, Immunological Phase 1
26 Angiogenesis Modulating Agents Phase 1
27 Antibodies Phase 1
28 Immunoglobulins Phase 1
29 Antibodies, Monoclonal Phase 1
30 Antifungal Agents Phase 1
31 Anti-Bacterial Agents Phase 1
32 Anti-Infective Agents Phase 1
33 Immunosuppressive Agents Phase 1
34 Antibiotics, Antitubercular Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effects of Vitamin B-6 Status on Homocysteine, Oxidative Stress, One-carbon Metabolism and Methylation: Cross-section, Case-control, Intervention and Follow-up Studies in Colorectal Cancer Unknown status NCT01426490 Phase 2, Phase 3
2 A Phase I/Biomarker Study of Bevacizumab in Combination With CNTO 95 in Patients With Refractory Solid Tumors Completed NCT00888043 Phase 1 CNTO 95 and avastin
3 A Phase I Study of Bevacizumab, Everolimus, and Panitumumab for Patients With Advanced Solid Tumors Completed NCT00586443 Phase 1 bevacizumab, everolimus, panitumumab

Search NIH Clinical Center for Colorectal Cancer 7

Genetic Tests for Colorectal Cancer 7

Anatomical Context for Colorectal Cancer 7

MalaCards organs/tissues related to Colorectal Cancer 7:

41
Brain, Colon, Liver, Lung

Publications for Colorectal Cancer 7

Articles related to Colorectal Cancer 7:

(show all 25)
# Title Authors PMID Year
1
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. 8
18372901 2008
2
The Usefulness of Intraoperative Colonic Irrigation and Primary Anastomosis in Patients Requiring a Left Colon Resection. 38
28761871 2017
3
Epigenetic regulation of voltage-gated potassium ion channel molecule Kv1.3 in mechanisms of colorectal cancer. 38
28472608 2017
4
Long-term Quality of Life of Patients With Permanent End Ileostomy: Results of a Nationwide Cross-Sectional Survey. 38
27926557 2017
5
Epigenetic silencing BCL6B induced colorectal cancer proliferation and metastasis by inhibiting P53 signaling. 38
25973304 2015
6
Prevalence, associations, and adequacy of treatment of major depression in patients with cancer: a cross-sectional analysis of routinely collected clinical data. 38
26360998 2014
7
FBXW7 mutations in patients with advanced cancers: clinical and molecular characteristics and outcomes with mTOR inhibitors. 38
24586741 2014
8
Epigenetic silencing of CXCL14 induced colorectal cancer migration and invasion. 38
24099668 2013
9
Fasting among Muslim cancer patients during the holy month of Ramadan. 38
22588434 2012
10
Local control of metastatic lung tumors treated with SBRT of 48 Gy in four fractions: in comparison with primary lung cancer. 38
19825814 2010
11
Brain metastases admissions in Sweden between 1987 and 2006. 38
19826419 2009
12
Two-stage hepatectomy: an analysis of a single center's experience. 38
16937794 2006
13
[Preoperative hepatic and regional arterial infusion chemotherapy in the prevention of liver metastasis after colorectal cancer surgery]. 38
16620710 2006
14
Molecular analysis of APC promoter methylation and protein expression in colorectal cancer metastasis. 38
15375009 2005
15
Association of Streptococcus bovis bacteremia with colonic neoplasia and extracolonic malignancy. 38
15249410 2004
16
Differential diagnosis of stenosing lesions at the hepatic hilus. 38
15085401 2004
17
A psychoneuroendocrine study of brain dopaminergic sensitivity in locally limited or metastatic cancer patients. 38
14758733 2003
18
Harmonic scalpel in laparoscopic colorectal surgery. 38
11289292 2001
19
Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. 38
9593786 1998
20
Plasma interleukin-6 is not a mediator of changes in lipoprotein lipase activity in cancer patients. 38
9356883 1997
21
[7 years of annual mass screening for colorectal cancer in office workers--usefulness of 3-day RPHA method]. 38
7796311 1995
22
Mutation analysis of K-ras oncogenes in gastroenterologic cancers by the amplified created restriction sites method. 38
8249918 1993
23
Neuroimmunotherapy of advanced solid neoplasms with single evening subcutaneous injection of low-dose interleukin-2 and melatonin: preliminary results. 38
8422280 1993
24
Measurement of a pancreatic cancer-associated antigen (DU-PAN-2) detected by a monoclonal antibody in sera of patients with digestive cancers. 38
3457770 1986
25
Combination of tissue polypeptide antigen (TPA) and carcino embryonic antigen (CEA) in different types of cancer. 38
4034127 1985

Variations for Colorectal Cancer 7

Expression for Colorectal Cancer 7

Search GEO for disease gene expression data for Colorectal Cancer 7.

Pathways for Colorectal Cancer 7

GO Terms for Colorectal Cancer 7

Sources for Colorectal Cancer 7

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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