CRCS8
MCID: CLR083
MIFTS: 20

Colorectal Cancer 8 (CRCS8)

Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Colorectal Cancer 8

MalaCards integrated aliases for Colorectal Cancer 8:

Name: Colorectal Cancer 8 56 29
Colorectal Cancer, Susceptibility to, 8 56 13
Colorectal Cancer, Susceptibility to, on Chromosome 14q 56
Colorectal Cancer on Chromosome 14q 56
Crcs8 56

Classifications:



External Ids:

OMIM 56 612589

Summaries for Colorectal Cancer 8

MalaCards based summary : Colorectal Cancer 8, also known as colorectal cancer, susceptibility to, 8, is related to colorectal cancer, hereditary nonpolyposis, type 8 and colorectal cancer. An important gene associated with Colorectal Cancer 8 is CRCS8 (Colorectal Cancer, Susceptibility To, 8). The drugs Oxaliplatin and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include lymph node, brain and liver.

More information from OMIM: 612589

Related Diseases for Colorectal Cancer 8

Diseases in the Colorectal Cancer family:

Colorectal Cancer 1 Colorectal Cancer 2
Colorectal Cancer 3 Colorectal Cancer 5
Colorectal Cancer 6 Colorectal Cancer 7
Colorectal Cancer 8 Colorectal Cancer 9
Colorectal Cancer 10 Colorectal Cancer 11
Colorectal Cancer 12 Familial Colorectal Cancer
Familial Colorectal Cancer Type X

Diseases related to Colorectal Cancer 8 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 colorectal cancer, hereditary nonpolyposis, type 8 12.0
2 colorectal cancer 11.4

Symptoms & Phenotypes for Colorectal Cancer 8

Clinical features from OMIM:

612589

Drugs & Therapeutics for Colorectal Cancer 8

Drugs for Colorectal Cancer 8 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 4 61825-94-3 5310940 9887054 6857599 43805
2
tannic acid Approved Phase 4 1401-55-4
3
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
4
Fluorouracil Approved Phase 4 51-21-8 3385

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized, Control Trial of Oxaliplatine Based Adjuvant Chemotherapy for Stage II/III Colorectal Cancer: 8 Cycles vs 12 Cycles Completed NCT00868816 Phase 4 12 cycles of oxaliplatine based adjuvant chemotherapy;8 cycles of oxaliplatine based adjuvant chemotherapy

Search NIH Clinical Center for Colorectal Cancer 8

Genetic Tests for Colorectal Cancer 8

Genetic tests related to Colorectal Cancer 8:

# Genetic test Affiliating Genes
1 Colorectal Cancer 8 29

Anatomical Context for Colorectal Cancer 8

MalaCards organs/tissues related to Colorectal Cancer 8:

40
Lymph Node, Brain, Liver

Publications for Colorectal Cancer 8

Articles related to Colorectal Cancer 8:

(show all 16)
# Title Authors PMID Year
1
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. 56
19011631 2008
2
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. 56
18372905 2008
3
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. 56
18372901 2008
4
Surgical Outcomes after Abdominoperineal Resection with Sacrectomy and Soft Tissue Reconstruction: Lessons Learned. 61
31537019 2020
5
New intra-abdominal mass after operation for colorectal cancer: desmoid tumor versus peritoneal seeding. 61
29550958 2018
6
PO-09 - Incidence of pre-operative and post-operative deep vein thrombosis in colorectal cancer surgery. Interim results of a prospective clinical study. 61
27161695 2016
7
NY-ESO-1 autoantibody as a tumor-specific biomarker for esophageal cancer: screening in 1969 patients with various cancers. 61
25906289 2016
8
Pharmacokinetics of panitumumab in a patient with liver dysfunction: a case report. 61
24258455 2014
9
[Initial research on FTIR spectroscopy of lyophilized serum from colorectal cancer patients]. 61
23697110 2013
10
[The sentinel lymph node technique in colorectal cancer using in vivo dye--utility and limits]. 61
17687856 2007
11
[Combined cytoreductive surgery and intraoperative hyperthermic chemo-perfusion for peritoneal carcinomatosis: methods, postoperative features and end results]. 61
17338240 2006
12
Phase II trial of capecitabine/irinotecan and capecitabine/oxaliplatin in advanced gastrointestinal cancers. 61
15207020 2004
13
Prognostic factor analysis for multiple brain metastases after gamma knife radiosurgery: results in 97 patients. 61
10421075 1999
14
Urokinase-type plasminogen activator and outcome in Dukes' B colorectal cancer. 61
7914963 1994
15
Radioimmunoscintigraphy with 111In labelled monoclonal antibody fragments (F(ab')2 BW 431/31) against CEA: radiolabelling, antibody kinetics and distribution, findings in tumour and non-tumour patients. 61
2616103 1989
16
[Immunoreactivity in colorectal cancer. Approaches for an immunologic diagnosis?]. 61
6857208 1983

Variations for Colorectal Cancer 8

Expression for Colorectal Cancer 8

Search GEO for disease gene expression data for Colorectal Cancer 8.

Pathways for Colorectal Cancer 8

GO Terms for Colorectal Cancer 8

Sources for Colorectal Cancer 8

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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